CN108126248A - A kind of preparation method of porous bacteria cellulose membrane material - Google Patents
A kind of preparation method of porous bacteria cellulose membrane material Download PDFInfo
- Publication number
- CN108126248A CN108126248A CN201810179656.2A CN201810179656A CN108126248A CN 108126248 A CN108126248 A CN 108126248A CN 201810179656 A CN201810179656 A CN 201810179656A CN 108126248 A CN108126248 A CN 108126248A
- Authority
- CN
- China
- Prior art keywords
- membrane material
- bacteria cellulose
- cellulose membrane
- preparation
- porous
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000463 material Substances 0.000 title claims abstract description 36
- 241000894006 Bacteria Species 0.000 title claims abstract description 31
- 239000001913 cellulose Substances 0.000 title claims abstract description 26
- 229920002678 cellulose Polymers 0.000 title claims abstract description 26
- 239000012528 membrane Substances 0.000 title claims abstract description 24
- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- 238000005520 cutting process Methods 0.000 claims abstract description 14
- 230000001580 bacterial effect Effects 0.000 claims 1
- 239000000835 fiber Substances 0.000 claims 1
- 238000000034 method Methods 0.000 abstract description 9
- 238000005553 drilling Methods 0.000 abstract description 3
- 239000011148 porous material Substances 0.000 abstract description 2
- 238000003698 laser cutting Methods 0.000 description 6
- 238000009954 braiding Methods 0.000 description 5
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 3
- 230000003111 delayed effect Effects 0.000 description 3
- 238000000605 extraction Methods 0.000 description 3
- 239000000741 silica gel Substances 0.000 description 3
- 229910002027 silica gel Inorganic materials 0.000 description 3
- 230000001629 suppression Effects 0.000 description 3
- 229910002092 carbon dioxide Inorganic materials 0.000 description 2
- 239000001569 carbon dioxide Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010062575 Muscle contracture Diseases 0.000 description 1
- 208000006111 contracture Diseases 0.000 description 1
- 238000000280 densification Methods 0.000 description 1
- 229910003460 diamond Inorganic materials 0.000 description 1
- 239000010432 diamond Substances 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 238000003466 welding Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/146—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/042—Polysaccharides
Abstract
The present invention provides a kind of preparation method of porous bacteria cellulose membrane material, it is sandwiched in mold after the dense film for the bacteria cellulose that humidity is 60 ~ 80% is cut, with the equipment cutting film of the cutting of ultraviolet laser, cutting obtains porosity 30 ~ 60% repeatedly, is uniformly distributed the porous bacteria cellulose membrane material in 1 ~ 2mm of diameter holes.The ultraviolet laser drilling method of this use of the present invention, the aperture formed on bacteria cellulose membrane material is larger, and is uniformly distributed, and the macropore of this uniform pore diameter can be to avoid bacteria planting, and the mechanics of obtained membrane material is isotropic, is operated convenient for doctor.
Description
Technical field
The present invention relates to a kind of preparation method of porous organic film material, more particularly to a kind of porous bacteria cellulose membrane material
The preparation method of material.
Background technology
The high molecular material material clinically used at present is prepared using the method for braiding, the side of this braiding
Method mainly has the disadvantage that：The hole of braiding is not uniform, is inevitably generated some apertures, and aperture, which easily generates bacterium, to be determined
It plants, causes inflammatory reaction；The method elasticity of braiding is excessive, in the case of stress, aperture deformation so that and effective aperture becomes smaller,
Bacteria planting is equally caused, the effect of scar bridge joint has been formed, has formed big cicatricial tissue, cause the contracture of mesh sheet；The side of braiding
Method so that mesh sheet is inconsistent in the elasticity of all directions, therefore when be implanted into this membrane material, doctor it is noted that the direction of placement,
It brings inconvenience.
Invention content
The present invention is intended to provide a kind of even aperture distribution, material are in the porous bacteria cellulose of isotropism mechanical property
Membrane material preparation method for material.
The present invention is realized by following scheme：
A kind of preparation method of porous bacteria cellulose membrane material cuts the dense film for the bacteria cellulose that humidity is 50 ~ 80%
It is placed in mold and fixes afterwards, cut with the equipment of the cutting for the ultraviolet laser that power is 10 ~ 30W with the rate of 200 ~ 600mm/s
Film, cutting times 5 ~ 12 times, obtains porosity 30 ~ 60%, is uniformly distributed the porous bacteria cellulose membrane material in 1 ~ 2mm of diameter holes.
Experiment is found, when the thickness of the dense film of the bacteria cellulose is 1 ~ 2cm, processing preparation process is easier to control
System.
Although laser cutting is a kind of existing processing technology, it is usually used in welding, punches, cuts, carbon dioxide laser
It is two kinds of common laser cutting techniques with ultraviolet laser, but the prior art indicate that commonly used in softer materials such as processing macromolecules
Material carbon dioxide laser cannot punch fine and close membrane material, and ultraviolet laser is then commonly used in high hardness molds such as processing cermets
Tool, catches fire, therefore this laser cutting technique is generally considered to be not appropriate for processing densification when processing organic film material
Organic film material.
Compared with existing porous bacteria cellulose membrane material preparation method for material, the ultraviolet laser drilling side of this use of the present invention
Method, the aperture formed on bacteria cellulose membrane material is larger, and is uniformly distributed, and the macropore of this uniform pore diameter can be to avoid
Bacteria planting；And the mechanics that this preparation method obtains membrane material is isotropic, therefore this material is when in use, just
Yu doctor operates.The hole shape that this drilling method is beaten can be customized arbitrarily, such as round, diamond shape or square hole.
Specific embodiment
Embodiment 1
A kind of preparation method of porous bacteria cellulose membrane material, by thickness be 1cm bacteria cellulose dense film, through squeeze
Pressure --- dry processing, until the humidity of film be 60 ~ 80%, then it is cut after sandwich in silica gel mould, keep the flatness of film, use
Power is the ultraviolet laser cutting equipment of 15W with the rate cutting film of 400mm/s, cutting times 10 times, by the round hole of setting
Shape processing, the other parameters of equipment are：Laser opens 30 μ s of delay, and laser closes 246 μ s of delay, redirects 250 μ s of delay, writes rapidly and prolong
When 40 μ s, turn round delay 30 μ s, point light extraction be delayed 18 μ s, Q frequency 70KHz, Q release 50 μ s, electric current 60A, the first pulse suppression time
2.8μs；Porosity 40 ~ 60% is made, is uniformly distributed the porous bacteria cellulose membrane material of diameter 1 ~ 2mm round holes.
Embodiment 2
A kind of preparation method of porous bacteria cellulose membrane material, by thickness be 2cm bacteria cellulose dense film, through squeeze
Pressure --- dry processing, until the humidity of film be 60 ~ 80%, then it is cut after sandwich in silica gel mould, keep the flatness of film, use
Power is the ultraviolet laser cutting equipment of 30W with the rate cutting film of 500mm/s, cutting times 12 times, by the square hole of setting
Shape processing, the other parameters of equipment are：Laser opens 15 μ s of delay, and laser closes 160 μ s of delay, redirects 200 μ s of delay, writes rapidly and prolong
When 20 μ s, turn round delay 23 μ s, point light extraction be delayed 8 μ s, Q frequency 10KHz, Q release 25 μ s, electric current 20A, the first pulse suppression time
0.1μs；Porosity 30 ~ 40% is made, is uniformly distributed the porous bacteria cellulose membrane material of the length of side 1 ~ 2mm square holes.
Embodiment 3
A kind of preparation method of porous bacteria cellulose membrane material, by thickness be 1cm bacteria cellulose dense film, through squeeze
Pressure --- dry processing, until the humidity of film be 50 ~ 70%, then it is cut after sandwich in silica gel mould, keep the flatness of film, use
Power is the ultraviolet laser cutting equipment of 10W with the rate cutting film of 200mm/s, cutting times 10 times, by the round hole of setting
Shape processing, the other parameters of equipment are：Laser opens 25 μ s of delay, and laser closes 246 μ s of delay, redirects 220 μ s of delay, writes rapidly and prolong
When 35 μ s, turn round delay 28 μ s, point light extraction be delayed 15 μ s, Q frequency 40KHz, Q release 36 μ s, electric current 40A, the first pulse suppression time
1.5μs；Porosity 40 ~ 60% is made, is uniformly distributed the porous bacteria cellulose membrane material of diameter 1 ~ 2mm round holes.
Claims (2)
1. a kind of preparation method of porous bacteria cellulose membrane material, it is characterised in that：By the bacterial fibers that humidity is 50 ~ 80%
It is fixed in merging mold after the dense film of element is cut, with the equipment of the cutting for the ultraviolet laser that power is 10 ~ 30W with 200 ~
The rate cutting film of 600mm/s, cutting times 5 ~ 12 times, obtains porosity 30 ~ 60%, is uniformly distributed the porous of 1 ~ 2mm of diameter holes
Bacteria cellulose membrane material.
2. the preparation method of porous bacteria cellulose membrane material as described in claim 1, it is characterised in that：The bacterium is fine
The thickness for tieing up the dense film of element is 1 ~ 2cm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810179656.2A CN108126248A (en) | 2018-03-05 | 2018-03-05 | A kind of preparation method of porous bacteria cellulose membrane material |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810179656.2A CN108126248A (en) | 2018-03-05 | 2018-03-05 | A kind of preparation method of porous bacteria cellulose membrane material |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108126248A true CN108126248A (en) | 2018-06-08 |
Family
ID=62431362
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810179656.2A Pending CN108126248A (en) | 2018-03-05 | 2018-03-05 | A kind of preparation method of porous bacteria cellulose membrane material |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108126248A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109125298A (en) * | 2018-07-16 | 2019-01-04 | 浙江工业大学 | A kind of isotropic drug containing tunica fibrosa, preparation method and collector |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9204232A (en) * | 1992-10-27 | 1993-04-06 | Joao Carlos Moreschi | PROCESS FOR OBTAINING BACTERIAL CELLULOSE MICROFIBRILLA MESH FOR MEDICAL AND VETERINARY USES, AND USE |
| CN1872022A (en) * | 2006-03-29 | 2006-12-06 | 钟春燕 | Gel face pack prepared from bacteroidal cellulose |
| CN101288778A (en) * | 2008-06-18 | 2008-10-22 | 天津大学 | Preparation method of porous bacteria cellulose sponges |
| CN101569764A (en) * | 2009-06-10 | 2009-11-04 | 天津大学 | Bacteria cellulose aquagel with undirectional hole array and preparation method |
| CN102274549A (en) * | 2011-07-10 | 2011-12-14 | 东华大学 | Method for preparing bacteria cellulose bracket material and product thereof |
| TW201212955A (en) * | 2010-09-20 | 2012-04-01 | Food Industry Res & Dev Inst | Method for making bacterial cellulose with controlled pore size and its use in wound dressing film |
| CN102600507A (en) * | 2012-03-08 | 2012-07-25 | 天津大学 | Cell culture support frame material and preparation method of cell culture support frame material |
| CN103272265A (en) * | 2013-06-07 | 2013-09-04 | 钟春燕 | Bacterial cellulose three-dimensional microporous scaffold preparation method |
| CN104157815A (en) * | 2014-08-22 | 2014-11-19 | 海南光宇生物科技有限公司 | Bacterial cellulose porous thin film and preparation method thereof |
| CN107208027A (en) * | 2014-12-22 | 2017-09-26 | 美国圣戈班性能塑料公司 | The system that cell is cultivated in controlled environment |
-
2018
- 2018-03-05 CN CN201810179656.2A patent/CN108126248A/en active Pending
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9204232A (en) * | 1992-10-27 | 1993-04-06 | Joao Carlos Moreschi | PROCESS FOR OBTAINING BACTERIAL CELLULOSE MICROFIBRILLA MESH FOR MEDICAL AND VETERINARY USES, AND USE |
| CN1872022A (en) * | 2006-03-29 | 2006-12-06 | 钟春燕 | Gel face pack prepared from bacteroidal cellulose |
| CN101288778A (en) * | 2008-06-18 | 2008-10-22 | 天津大学 | Preparation method of porous bacteria cellulose sponges |
| CN101569764A (en) * | 2009-06-10 | 2009-11-04 | 天津大学 | Bacteria cellulose aquagel with undirectional hole array and preparation method |
| TW201212955A (en) * | 2010-09-20 | 2012-04-01 | Food Industry Res & Dev Inst | Method for making bacterial cellulose with controlled pore size and its use in wound dressing film |
| CN102274549A (en) * | 2011-07-10 | 2011-12-14 | 东华大学 | Method for preparing bacteria cellulose bracket material and product thereof |
| CN102600507A (en) * | 2012-03-08 | 2012-07-25 | 天津大学 | Cell culture support frame material and preparation method of cell culture support frame material |
| CN103272265A (en) * | 2013-06-07 | 2013-09-04 | 钟春燕 | Bacterial cellulose three-dimensional microporous scaffold preparation method |
| CN104157815A (en) * | 2014-08-22 | 2014-11-19 | 海南光宇生物科技有限公司 | Bacterial cellulose porous thin film and preparation method thereof |
| CN107208027A (en) * | 2014-12-22 | 2017-09-26 | 美国圣戈班性能塑料公司 | The system that cell is cultivated in controlled environment |
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|---|
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| 刘长生: "细菌纤维素及其改性膜应用于医用敷料的初步研究", 《中国优秀硕士学位论文全文数据库 医药卫生科技辑》 * |
| 虞钢: "《激光先进制造技术及其应用》", 31 December 2016, 国防工业出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109125298A (en) * | 2018-07-16 | 2019-01-04 | 浙江工业大学 | A kind of isotropic drug containing tunica fibrosa, preparation method and collector |
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| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
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| RJ01 | Rejection of invention patent application after publication | ||
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Application publication date: 20180608 |