CN108126126A - A kind of Ganluxiaoke capsules and preparation method - Google Patents

A kind of Ganluxiaoke capsules and preparation method Download PDF

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Publication number
CN108126126A
CN108126126A CN201810088142.6A CN201810088142A CN108126126A CN 108126126 A CN108126126 A CN 108126126A CN 201810088142 A CN201810088142 A CN 201810088142A CN 108126126 A CN108126126 A CN 108126126A
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China
Prior art keywords
capsule
water
preparation
fine powder
ganluxiaoke
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CN201810088142.6A
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Chinese (zh)
Inventor
肖东
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CHONGQING RUEPEAK PHARMACEUTICAL Co Ltd
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CHONGQING RUEPEAK PHARMACEUTICAL Co Ltd
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Priority to CN201810088142.6A priority Critical patent/CN108126126A/en
Publication of CN108126126A publication Critical patent/CN108126126A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/64—Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/42—Cucurbitaceae (Cucumber family)
    • A61K36/428—Trichosanthes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/488—Pueraria (kudzu)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/57—Magnoliaceae (Magnolia family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/79—Schisandraceae (Schisandra family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/80—Scrophulariaceae (Figwort family)
    • A61K36/804—Rehmannia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/894—Dioscoreaceae (Yam family)
    • A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Cosmetics (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

The invention discloses a kind of Ganluxiaoke capsules and preparation method, preparation method is specially：Four taste such as pueraria lobata, glutinous rehmannia, corn stigma, root of Chinese trichosanthes is taken, adds in and decocts 5 hours, filtration, filtrate is concentrated into right amount；Radix Astragali, kadsura longepedunculata, Chinese yam is added to be ground into coarse powder, is mixed thoroughly with above-mentioned partial concentration liquid, is dried, crushed into fine powder, be sieved, granulation, glibenclamide fine powder granulation when add in, it is encapsulated, system 1000 to get；Preparation process is efficient, decocts paste-forming rate height using water extraction process plus 12 times of water, drying temperature controls less than 60 degrees Celsius, 0.08 0.95Mpa of pressure crushes more than 91% flour extraction, because this product is capsule, intermediate powder is directly filled into capsule after mixing, technique is simpler.

Description

A kind of Ganluxiaoke capsules and preparation method
Technical field
The present invention relates to field of medicine preparations, specially a kind of Ganluxiaoke capsules and preparation method.
Background technology
The product prescription is by the seven taste Chinese medicine such as pueraria lobata, glutinous rehmannia and chemical drugs form simply Chinese and Western combined preparation, for controlling More drinks to be treated, diuresis, eats more, become thin, body is tired powerless, the type of deficiency of both QI and YIN diabetes of sleep poor pain in the back, glucose in urine and blood glucose rise, due to Its clinical efficacy is preferably deep to be welcome by numerous doctors and patients.Wasting-thirst capsule is that Chinese patent drug kind diabetes pill is formed by improving dosage form. Its preparation process has standard Chinese patent drug diabetes pill preparation process entirely by reference to country, is only changed in moulding process, Semi-finished product powder is directly loadable into capsule and is formed.Wasting-thirst capsule goes out the basic phase of amount of product with diabetes pill same preparation recipe quantity Together, therefore clinical drug dosage does not change.By the wasting-thirst capsule of improving dosage form, disintegration time limited has compared with diabetes pill It is reduced, and water-bindered pill dosage form adds in a certain amount of binder (molding for being conducive to preparation) in formulation manufacturing processes, and capsule Agent is that drug semi-finished product are directly loadable into capsule, therefore the disintegrating property of drug is preferable, can cover the bad smell of drug.This It is the main purpose that this product carries out improving dosage form developmental research.
Invention content
The object of the present invention is to provide a kind of Ganluxiaoke capsules and preparation method, preparation method is simple, is readily produced, Solves deficiency of the prior art.
To achieve the above object, the present invention provides following technical solution：A kind of Ganluxiaoke capsules and preparation method, by glue Capsule filler and capsule shells composition, capsule filling are made by ingredient of following component：Pueraria lobata, glutinous rehmannia, corn stigma, root of Chinese trichosanthes, Radix Astragali, Schisandra chinensis, Chinese yam, glibenclamide；
(1) water extraction process：The extraction process by water of wasting-thirst capsule takes pueraria lobata, glutinous rehmannia, corn stigma, day with reference to diabetes pill technique Four taste such as pollen adds 12 times of amount of water to decoct 5 hours, filtration, and filtrate concentration is appropriate；Medicine is sufficiently humidified so as to decocting to impregnate 2 hours Material is also beneficial to the leaching of active ingredient；Above-mentioned medicinal material adds 12 times of water to decoct 5 hours, and two layers of silk filtration, the dregs of a decoction put centrifuge The middle liquid (4000 revs/min) for collecting dregs of a decoction absorption, merges with filtrate, and water vapour jacketed pan is concentrated into a certain amount of, centrifugation (14000 revs/min, 20 minutes), supernatant continues to be concentrated into the medicinal extract of relative density 1.35-1.40 (60 degrees Celsius), spare；
(2) it crushes and mixes, dries, crushes again：It gets it filled material Radix Astragali, Schisandra chinensis, Chinese yam etc., puts and be not added with sieving in pulverizer Net is smashed to appropriate particle, is put stirrer for mixing with above-mentioned water extraction medicinal extract, is spread out to put in stainless steel square plate and be dried under reduced pressure case Middle drying, temperature control 60 degrees Celsius hereinafter, 0.08~0.095Mpa of pressure, until being completely dried, weighed weight, dry cream rate is 11.23%, above-mentioned herb in granule form and the medicinal extract object that mixes up are ground into fine powder, are sieved, flour extraction is more than 91%；Lattice arrange in prescription This urea dosage is very low, and general sieving mixing is uneven, disperses non-uniform influence curative effect of medication and quality, and can cause not Good reaction；Therefore the method that facing-up should be used, separately takes recipe quantity glibenclamide to be ground into fine powder, after above-mentioned fine powder facing-up, then Sieving mixing is carried out, is then fitted into fine drug powder in capsule using capsule filling machine, by the weighed inspection of batch, determines capsule Content average weight 0.42g/.
It is same as the prior art or the prior art can be used realized that part is not directed in the invention.
Compared with prior art, beneficial effects of the present invention are as follows：
(1) preparation process is efficient, decocts paste-forming rate height using water extraction process plus 12 times of water, drying temperature control 60 is taken the photograph Below family name's degree, pressure 0.08-0.95Mpa crushes more than 91% flour extraction.
(2) because this product is capsule, intermediate powder is directly filled into capsule after mixing, technique is simpler.
Specific embodiment
Below in conjunction with the embodiment of the present invention, the technical solution in the embodiment of the present invention is clearly and completely described, Obviously, described embodiment is only part of the embodiment of the present invention, instead of all the embodiments, based in the present invention Embodiment, those of ordinary skill in the art's all other embodiments obtained without making creative work, all Belong to the scope of protection of the invention.
Embodiment：A kind of Ganluxiaoke capsules and preparation method, are made of capsule filling and capsule shells, capsule filling It is made by ingredient of following component：Pueraria lobata, glutinous rehmannia, corn stigma, root of Chinese trichosanthes, Radix Astragali, Schisandra chinensis, Chinese yam, glibenclamide；
A kind of Ganluxiaoke capsules and preparation method, preparation method are specially：
(1) water extraction process：The extraction process by water of wasting-thirst capsule takes pueraria lobata, glutinous rehmannia, corn stigma, day with reference to diabetes pill technique Four taste such as pollen adds 12 times of amount of water to decoct 5 hours, filtration, and filtrate concentration is appropriate；Medicine is sufficiently humidified so as to decocting to impregnate 2 hours Material is also beneficial to the leaching of active ingredient；Above-mentioned medicinal material adds 12 times of water to decoct 5 hours, and two layers of silk filtration, the dregs of a decoction put centrifuge The middle liquid (4000 revs/min) for collecting dregs of a decoction absorption, merges with filtrate, and water vapour jacketed pan is concentrated into a certain amount of, centrifugation (14000 revs/min, 20 minutes), supernatant continues to be concentrated into the medicinal extract of relative density 1.35-1.40 (60 degrees Celsius), spare；
(2) it crushes and mixes, dries, crushes again：It gets it filled material Radix Astragali, Schisandra chinensis, Chinese yam etc., puts and be not added with sieving in pulverizer Net is smashed to appropriate particle, is put stirrer for mixing with above-mentioned water extraction medicinal extract, is spread out to put in stainless steel square plate and be dried under reduced pressure case Middle drying, temperature control 60 degrees Celsius hereinafter, 0.08~0.095Mpa of pressure, until being completely dried, weighed weight, dry cream rate is 11.23%, above-mentioned herb in granule form and the medicinal extract object that mixes up are ground into fine powder, are sieved, flour extraction is more than 91%；Lattice arrange in prescription This urea dosage is very low, and general sieving mixing is uneven, disperses non-uniform influence curative effect of medication and quality, and can cause not Good reaction；Therefore the method that facing-up should be used, separately takes recipe quantity glibenclamide to be ground into fine powder, after above-mentioned fine powder facing-up, then Sieving mixing is carried out, is then fitted into fine drug powder in capsule using capsule filling machine, by the weighed inspection of batch, determines capsule Content average weight 0.42g/.
In summary：Preparation process is efficient, and paste-forming rate height, drying temperature control are decocted using water extraction process plus 12 times of water 60 degrees Celsius of system crushes more than 91% flour extraction hereinafter, pressure 0.08-0.95Mpa, because this product is capsule, by intermediate powder Capsule is directly filled at end after mixing, and technique is simpler.
The basic principles, main features and the advantages of the invention have been shown and described above, for this field skill For art personnel, it is clear that the present invention is not limited to the details of above-mentioned exemplary embodiment, and without departing substantially from the present invention spirit or In the case of essential characteristic, the present invention can be realized in other specific forms；Therefore, in all respects, should all incite somebody to action Embodiment regards exemplary as, and is non-limiting, the scope of the present invention by appended claims rather than on state Bright restriction, it is intended that including all changes falling within the meaning and scope of the equivalent requirements of the claims in the present invention It is interior.
In addition, it should be understood that although this specification is described in terms of embodiments, but not each embodiment is only wrapped Containing an independent technical solution, this description of the specification is merely for the sake of clarity, and those skilled in the art should It considers the specification as a whole, the technical solutions in each embodiment can also be properly combined, forms those skilled in the art The other embodiment being appreciated that.

Claims (2)

1. a kind of Ganluxiaoke capsules, it is characterised in that：Be made of capsule filling and capsule shells, capsule filling press ingredient by Following component is made：Pueraria lobata, glutinous rehmannia, corn stigma, root of Chinese trichosanthes, Radix Astragali, Schisandra chinensis, Chinese yam, glibenclamide.
2. a kind of Ganluxiaoke capsules and preparation method, which is characterized in that preparation method is specially：
(1) water extraction process：The extraction process by water of wasting-thirst capsule takes pueraria lobata, glutinous rehmannia, corn stigma, root of Chinese trichosanthes with reference to diabetes pill technique Deng four tastes, 12 times of amount of water is added to decoct 5 hours, filtration, filtrate concentration is in right amount；Medicinal material is sufficiently humidified so as to decocting to impregnate 2 hours Be conducive to the leaching of active ingredient；Above-mentioned medicinal material adds 12 times of water to decoct 5 hours, and two layers of silk filtration, the dregs of a decoction are put in centrifuge and received Collect the dregs of a decoction absorption liquid (4000 revs/min), merges with filtrate, water vapour jacketed pan be concentrated into it is a certain amount of, centrifuge (14000 turns/ Point, 20 minutes), supernatant continues to be concentrated into the medicinal extract of relative density 1.35-1.40 (60 degrees Celsius), spare；
(2) it crushes and mixes, dries, crushes again：It gets it filled material Radix Astragali, Schisandra chinensis, Chinese yam etc., puts and sieve is not added in pulverizer, beat Appropriate particle is broken to, stirrer for mixing is put with above-mentioned water extraction medicinal extract, spreads out to put to be dried under reduced pressure in case in stainless steel square plate and do Dry, temperature controls 60 degrees Celsius hereinafter, 0.08~0.095Mpa of pressure, until being completely dried, weighed weight, dry cream rate is 11.23%, above-mentioned herb in granule form and the medicinal extract object that mixes up are ground into fine powder, are sieved, flour extraction is more than 91%；Lattice arrange in prescription This urea dosage is very low, and general sieving mixing is uneven, disperses non-uniform influence curative effect of medication and quality, and can cause not Good reaction；Therefore the method that facing-up should be used, separately takes recipe quantity glibenclamide to be ground into fine powder, after above-mentioned fine powder facing-up, then Sieving mixing is carried out, is then fitted into fine drug powder in capsule using capsule filling machine, by the weighed inspection of batch, determines capsule Content average weight 0.42g/.
CN201810088142.6A 2018-01-30 2018-01-30 A kind of Ganluxiaoke capsules and preparation method Pending CN108126126A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201810088142.6A CN108126126A (en) 2018-01-30 2018-01-30 A kind of Ganluxiaoke capsules and preparation method

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201810088142.6A CN108126126A (en) 2018-01-30 2018-01-30 A kind of Ganluxiaoke capsules and preparation method

Publications (1)

Publication Number Publication Date
CN108126126A true CN108126126A (en) 2018-06-08

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN201810088142.6A Pending CN108126126A (en) 2018-01-30 2018-01-30 A kind of Ganluxiaoke capsules and preparation method

Country Status (1)

Country Link
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Application publication date: 20180608