CN108125920A - A kind of pill matrix microspheres material based on chitosan and preparation method thereof - Google Patents
A kind of pill matrix microspheres material based on chitosan and preparation method thereof Download PDFInfo
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- CN108125920A CN108125920A CN201810179210.XA CN201810179210A CN108125920A CN 108125920 A CN108125920 A CN 108125920A CN 201810179210 A CN201810179210 A CN 201810179210A CN 108125920 A CN108125920 A CN 108125920A
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- 0 *C(*C(C(CO)O[C@@](C1NP(O)(OC(C([C@](C(C2*P(O)(O)=O)OP(O)(O)=O)OP(O)(O)=O)OP(O)(O)=O)[C@]2OP(O)(O)=O)=O)O[C@](C(CO)O[C@](C2N)O)C2O)=C1O)[C@@](C(C1O)N)OC(CO)[C@]1O Chemical compound *C(*C(C(CO)O[C@@](C1NP(O)(OC(C([C@](C(C2*P(O)(O)=O)OP(O)(O)=O)OP(O)(O)=O)OP(O)(O)=O)[C@]2OP(O)(O)=O)=O)O[C@](C(CO)O[C@](C2N)O)C2O)=C1O)[C@@](C(C1O)N)OC(CO)[C@]1O 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/24—Crosslinking, e.g. vulcanising, of macromolecules
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2305/00—Characterised by the use of polysaccharides or of their derivatives not provided for in groups C08J2301/00 or C08J2303/00
- C08J2305/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
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Abstract
The invention discloses a kind of pill matrix microspheres materials based on chitosan and preparation method thereof.The preparation method of the pill matrix microspheres material based on chitosan includes the following steps：Chitosan aqueous solution is added dropwise in phytic acid aqueous solution, it is reacted to get to the pill matrix microspheres material based on chitosan.The present invention is reacted at normal temperatures using natural raw material, and experiment is simple and safe, and easy to operate, experimental facilities is cheap, can amplify production；The microballoon of gained is uniform, safe and non-toxic, edible.The present invention is raw material using existing chitosans a large amount of in nature and phytic acid, at normal temperatures and pressures, by the way that experimental implementation is simply added dropwise, obtains chitosan-based pill matrix microspheres material.Obtained chitosan-based pill matrix microspheres scantling is uniform, and pill weight variation is small, and pellet roundness is easy to control.
Description
Technical field
The present invention relates to a kind of pill matrix microspheres materials based on chitosan and preparation method thereof, belong to functional material
Field.
Background technology
Pill refers to bolus of drug made of the method using dripping.Typically, it is by solid or liquid medicine
Dissolving, is suspended or is emulsified in certain matrix, be added dropwise to later in the solution not miscible with drug matrices.Due to surface tension
Effect, it is final to shrink condensation spheroiding or class ball-type pill.Pill also is available for external application and part enters mainly for being administered orally
The uses such as ear, nose, eye, rectum, vagina.Pill has the characteristics that compared with other kinds of drug：Medicament contg is accurate,
Drug loss is small in preparation process；Stable quality can make drug play the advantages that efficient, quick, long-acting.Pill from come out to
The present has the history of more than 70 years, and preparation process, theory, equipment and kind have very big development.At present, pill is ground
Study carefully and be concentrated mainly on several aspects such as " three is small ", " triple effect " and " three just ".So-called " three is small " refer to small dosage, small toxicity,
Small side effects；" triple effect " refers specifically to：Efficiently, it is long-acting, quick-acting；" three just " refers to：Facilitate medication, be convenient for carrying, conveniently
Storage.The research and development of pill have broad prospects and huge potential market.
The preparation of pill is mainly oozed naturally using liquid gravity by dropper mouth, subsequently into forming ball in coolant
Agent.Nearly ten years, due to the fast development of science and technology, the production equipment of pill, preparation process and types of drugs have well
The development of spray formula, but it is slow for the research and development of pill new medium auxiliary material.So far, most of pill matrix choosing
It is polyethylene glycol, also has research report in part to utilize gelatin, poloxamer, polyethers etc..Poloxamer, polyethers etc. are to utilize
Compound prepared by artificial synthesized method although can be medicinal, all has different degrees of hemolytic.Although gelatin
From natural, essentially from the skin and bone of animal, but in order to avoid zoonosis, such as rabid ox disease, hoof-and-mouth disease
Etc. diseases, the matrix auxiliary material of current many animal origins is all disabling.Show supplemented by polyethylene glycol in addition, studying for a long period of time
The pill for expecting to prepare is there are a series of problem, for example, easy to aging, dry and cracked, unstable etc..
Therefore, in order to improve the product quality of pill, broadening pill medical product application, push pill
The development of dosage form, promotes the internationalization of pill product, and research and utilization is easy to get safe natural materials as raw material, develops safe nothing
The food-grade novel dripping pill agent host material of poison is a challenging subject, is had far-reaching significance.
Invention content
The object of the present invention is to provide a kind of pill matrix microspheres material based on chitosan and preparation method thereof, the systems
Preparation Method can carry out batch large-scale production, and extensive with raw material sources, cheap, equipment is simple, and operation is easy, low consumption
Can, obtained pill host material has many advantages, such as that pill weight variation is small, pellet roundness is easy to control.
Pill host material provided by the invention is possibly able to substitute currently used material, pushes and further promotees
Into the internationalization of pill drug.
The present invention prepares pill matrix microspheres material using chitosan and phytic acid, they are present in nature,
Reaction, and then quick (in moment) generation pill host material, reaction schematic diagram such as Fig. 1 institutes can be crosslinked both under room temperature
Show.
The structural formula of the chitosan is as shown in Equation 1：
The structural formula of the phytic acid is as shown in Equation 2：
Site during the two progress cross-linking reaction is as shown in Equation 3：
Specifically, the preparation method of the pill matrix microspheres material provided by the invention based on chitosan, including as follows
Step：
Chitosan aqueous solution is added dropwise in phytic acid aqueous solution, it is reacted to get to the pill based on chitosan
Matrix microspheres material.
In above-mentioned preparation method, the molecular weight of the chitosan can be 2 × 105~5 × 105；
The mass fraction of the chitosan aqueous solution can be 0.05%~3%.
In above-mentioned preparation method, the chitosan aqueous solution is prepared using glacial acetic acid aqueous solution.
In above-mentioned preparation method, the mass fraction of the glacial acetic acid aqueous solution can be 0.5%~4%.
In above-mentioned preparation method, the mass fraction of the phytic acid aqueous solution is 0.05%~10%.
In above-mentioned preparation method, the chitosan aqueous solution is added dropwise in the phytic acid aqueous solution using syringe；
Therefore, so as to change the size of pill matrix microspheres, drop can be can control by adjusting the size of the syringe needle of the syringe of use
A diameter of 1~40mm of pill matrix microspheres.
The present invention is reacted at normal temperatures using natural raw material, and experiment is simple and safe, and easy to operate, experimental facilities is cheap,
Production can be amplified；The microballoon of gained is uniform, safe and non-toxic, edible.
The present invention is raw material using existing chitosans a large amount of in nature and phytic acid, at normal temperatures and pressures, by simple
Dropwise addition experimental implementation, obtain chitosan-based pill matrix microspheres material.Obtained chitosan-based pill matrix is micro-
Ball material size uniform, pill weight variation is small, and pellet roundness is easy to control.
Description of the drawings
Fig. 1 is chitosan and the schematic diagram of reaction of phytic acid in the method for the present invention.
Fig. 2 is the pill matrix microspheres material based on chitosan.
Fig. 3 is the pictorial diagram of the chitosan pill host material prepared by various sizes of syringe needle.
Fig. 4 is the pictorial diagram of the chitosan pill host material of coated pigment.
Specific embodiment
Experimental method used in following embodiments is conventional method unless otherwise specified.
The materials, reagents and the like used in the following examples is commercially available unless otherwise specified.
The molecular weight of the chitosan used in following embodiments is 2 × 105~5 × 105。
The preparation of embodiment 1, pill matrix microspheres material based on 2wt% chitosans
In 250mL beakers, the deionized water of 150mL is added in, glacial acetic acid 3.0g is added in later, is sufficiently stirred.Delay later
Slow addition chitosan 3g, persistently stirs 2h, obtains the chitosan aqueous solution of 2wt%, and labeled as solution 1.At another
In 250mL beakers, the deionized water water of 150mL is added in, 70% phytic acid 3g is added in later, is sufficiently stirred, obtains 1.4wt%'s
Phytic acid aqueous solution mark, is denoted as solution 2.By solution 1 by syringe, ceaselessly it is added dropwise in solution 2, moment obtains gathering based on shell
The pill matrix microspheres material of sugar, as shown in Figure 2.
As seen from Figure 2, the size uniform of chitosan-based pill matrix microspheres material manufactured in the present embodiment, ball weight
Difference is small.
The preparation of embodiment 2, pill matrix microspheres material based on 0.05wt% chitosans
In 250mL beakers, the deionized water of 150mL is added in, glacial acetic acid 0.75g is added in later, is sufficiently stirred.Delay later
Slow addition chitosan 0.75g, persistently stirs 2h, obtains the chitosan aqueous solution of 0.05wt%, and labeled as solution 1. another
In one 250mL beaker, the deionized water water of 150mL is added in, 70% phytic acid 3g is added in later, is sufficiently stirred, obtains
The phytic acid aqueous solution mark of 1.4wt%, is denoted as solution 2.By solution 1 by syringe, ceaselessly it is added dropwise in solution 2, moment obtains
To the pill matrix microspheres material based on chitosan.
The size uniform of pill matrix microspheres material manufactured in the present embodiment, pill weight variation are small.
The preparation of embodiment 3, pill matrix microspheres material based on 0.07wt% phytic acid
In 250mL beakers, the deionized water of 150mL is added in, glacial acetic acid 3.0g is added in later, is sufficiently stirred.Delay later
Slow addition chitosan 3g, persistently stirs 2h, obtains the chitosan aqueous solution of 2wt%, and labeled as solution 1. at another
In 250mL beakers, the deionized water water of 150mL is added in, 70% phytic acid 0.15g is added in later, is sufficiently stirred, obtains
The phytic acid aqueous solution mark of 0.07wt%, is denoted as solution 2.By solution 1 by syringe, ceaselessly it is added dropwise in solution 2, moment obtains
To the pill matrix microspheres material based on chitosan.
The size uniform of pill matrix microspheres material manufactured in the present embodiment, pill weight variation are small.
Embodiment 4, a diameter of 1mm based on chitosan pill matrix microspheres material preparation
In 250mL beakers, the deionized water of 150mL is added in, glacial acetic acid 3.0g is added in later, is sufficiently stirred.Delay later
Slow addition chitosan 3g, persistently stirs 2h, obtains the chitosan aqueous solution of 2wt%, and labeled as solution 1. at another
In 250mL beakers, the deionized water water of 150mL is added in, 70% phytic acid 3g is added in later, is sufficiently stirred, obtains 1.4wt%'s
Phytic acid aqueous solution mark, is denoted as solution 2.By solution 1 by volume be 1mL syringe needle, be ceaselessly added dropwise in solution 2,
Moment obtains the chitosan pill matrix microspheres material of a diameter of 1mm.
The size uniform of pill matrix microspheres material manufactured in the present embodiment, pill weight variation are small.
Embodiment 5, a diameter of 40mm based on chitosan pill matrix microspheres material preparation
In 250mL beakers, the deionized water of 150mL is added in, glacial acetic acid 3.0g is added in later, is sufficiently stirred.Delay later
Slow addition chitosan 3g, persistently stirs 2h, obtains the chitosan aqueous solution of 2wt%, and labeled as solution 1. at another
In 250mL beakers, the deionized water water of 150mL is added in, 70% phytic acid 3g is added in later, is sufficiently stirred, obtains 1.4wt%'s
Phytic acid aqueous solution mark, is denoted as solution 2.By solution 1 by the syringe needle that volume is 500mL, it is ceaselessly added dropwise to solution 2
In, moment obtains the chitosan pill matrix microspheres material of a diameter of 40mm.
The present embodiment and embodiment 4 are using the chitosan pill host material prepared by various sizes of syringe needle
As shown in Figure 3, it is seen that by adjusting the size of the syringe needle of the syringe of use, the size of pill matrix microspheres can be changed, obtain
The size uniform of pill matrix microspheres arrived, pill weight variation are small.
Embodiment 6, coated pigment the pill matrix microspheres material based on chitosan preparation
In 250mL beakers, the deionized water of 150mL is added in, glacial acetic acid 3.0g is added in later, is sufficiently stirred.Delay later
Slow addition chitosan 3g, persistently stirs 2h, obtains the chitosan aqueous solution of 2wt%, adds in the orchil of 1mL later, and
Labeled as solution 1.In another 250mL beaker, the deionized water water of 150mL is added in, 70% phytic acid 3g is added in later, fills
Divide stirring, obtain the phytic acid aqueous solution mark of 1.4wt%, be denoted as solution 2.By solution 1 by syringe, it is ceaselessly added dropwise to solution
In 2, moment obtains the pill matrix microspheres material based on chitosan of coated pigment, as shown in Figure 4.
As seen from Figure 4, the size uniform of chitosan-based pill matrix microspheres material manufactured in the present embodiment, ball weight
Difference is small.
Claims (9)
1. a kind of preparation method of the pill matrix microspheres material based on chitosan, includes the following steps：
Chitosan aqueous solution is added dropwise in phytic acid aqueous solution, it is reacted to get to the pill matrix based on chitosan
Micro-sphere material.
2. preparation method according to claim 1, it is characterised in that：The molecular weight of the chitosan is 2 × 105~5 ×
105；
The mass fraction of the chitosan aqueous solution is 0.05%~3%.
3. preparation method according to claim 1 or 2, it is characterised in that：The shell is prepared using glacial acetic acid aqueous solution to gather
Sugar aqueous solution.
4. preparation method according to claim 3, it is characterised in that：The mass fraction of the glacial acetic acid aqueous solution is
0.5%~4%.
5. according to the preparation method described in any one of claim 1-4, it is characterised in that：The quality of the phytic acid aqueous solution point
Number is 0.05%~10%.
6. preparation method according to any one of claims 1-5, it is characterised in that：Using syringe by the chitosan
Aqueous solution is added dropwise in the phytic acid aqueous solution.
7. the pill matrix microspheres material based on chitosan prepared by any one of claim 1-6 the methods.
8. the pill matrix microspheres material according to claim 7 based on chitosan, it is characterised in that：It is described to be based on shell
A diameter of 1~40mm of the pill matrix microspheres material of glycan.
9. using the pill matrix microspheres material based on chitosan claim 7 or 8 Suo Shu as the pill of matrix.
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| CN201810179210.XA CN108125920A (en) | 2018-03-05 | 2018-03-05 | A kind of pill matrix microspheres material based on chitosan and preparation method thereof |
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| CN201810179210.XA CN108125920A (en) | 2018-03-05 | 2018-03-05 | A kind of pill matrix microspheres material based on chitosan and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112823790A (en) * | 2019-11-21 | 2021-05-21 | 成都百裕制药股份有限公司 | A ginkgolide dripping pill and its preparation method |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101784267A (en) * | 2007-06-18 | 2010-07-21 | 延世大学校产学协力团 | The slow release chitosan capsules that comprises chitosan and phytic acid |
| WO2016091778A1 (en) * | 2014-12-12 | 2016-06-16 | Kiomed Pharma | Chitosan hydrogel microbead |
| CN106833079A (en) * | 2016-12-26 | 2017-06-13 | 中国科学院海洋研究所 | A kind of Porous Chitosan Microspheres for coating corrosion inhibiter and its preparation and application |
| CN109482110A (en) * | 2017-09-12 | 2019-03-19 | 中国科学院兰州化学物理研究所苏州研究院 | A kind of preparation method and application of aquagel |
-
2018
- 2018-03-05 CN CN201810179210.XA patent/CN108125920A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101784267A (en) * | 2007-06-18 | 2010-07-21 | 延世大学校产学协力团 | The slow release chitosan capsules that comprises chitosan and phytic acid |
| WO2016091778A1 (en) * | 2014-12-12 | 2016-06-16 | Kiomed Pharma | Chitosan hydrogel microbead |
| CN106833079A (en) * | 2016-12-26 | 2017-06-13 | 中国科学院海洋研究所 | A kind of Porous Chitosan Microspheres for coating corrosion inhibiter and its preparation and application |
| CN109482110A (en) * | 2017-09-12 | 2019-03-19 | 中国科学院兰州化学物理研究所苏州研究院 | A kind of preparation method and application of aquagel |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112823790A (en) * | 2019-11-21 | 2021-05-21 | 成都百裕制药股份有限公司 | A ginkgolide dripping pill and its preparation method |
| CN112823790B (en) * | 2019-11-21 | 2022-07-05 | 成都百裕制药股份有限公司 | A ginkgolide dripping pill and its preparation method |
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