CN108102049A - The preparation method of hydrogel - Google Patents

The preparation method of hydrogel Download PDF

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Publication number
CN108102049A
CN108102049A CN201611054917.5A CN201611054917A CN108102049A CN 108102049 A CN108102049 A CN 108102049A CN 201611054917 A CN201611054917 A CN 201611054917A CN 108102049 A CN108102049 A CN 108102049A
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CN
China
Prior art keywords
hydrogel
preparation
monomer
hydrophilic
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201611054917.5A
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Chinese (zh)
Inventor
陈广炎
刘飏
刘福军
罗建华
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Danyang Yaben Chemical Technology Co Ltd
Original Assignee
Danyang Yaben Chemical Technology Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Danyang Yaben Chemical Technology Co Ltd filed Critical Danyang Yaben Chemical Technology Co Ltd
Priority to CN201611054917.5A priority Critical patent/CN108102049A/en
Publication of CN108102049A publication Critical patent/CN108102049A/en
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F290/00—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups
    • C08F290/02—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups on to polymers modified by introduction of unsaturated end groups
    • C08F290/06—Polymers provided for in subclass C08G
    • C08F290/062—Polyethers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
    • C08G63/08—Lactones or lactides
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G64/00—Macromolecular compounds obtained by reactions forming a carbonic ester link in the main chain of the macromolecule
    • C08G64/20—General preparatory processes
    • C08G64/30—General preparatory processes using carbonates
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
    • C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
    • C08J3/075—Macromolecular gels
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K3/00—Use of inorganic substances as compounding ingredients
    • C08K3/18—Oxygen-containing compounds, e.g. metal carbonyls
    • C08K3/20—Oxides; Hydroxides
    • C08K3/22—Oxides; Hydroxides of metals
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00—Use of organic ingredients
    • C08K5/04—Oxygen-containing compounds
    • C08K5/05—Alcohols; Metal alcoholates
    • C08K5/053—Polyhydroxylic alcohols
    • G—PHYSICS
    • G02—OPTICS
    • G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
    • G02C7/00—Optical parts
    • G02C7/02—Lenses; Lens systems ; Methods of designing lenses
    • G02C7/04—Contact lenses for the eyes
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2367/00—Characterised by the use of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Derivatives of such polymers
    • C08J2367/04—Polyesters derived from hydroxy carboxylic acids, e.g. lactones
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2369/00—Characterised by the use of polycarbonates; Derivatives of polycarbonates
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2451/00—Characterised by the use of graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives of such polymers
    • C08J2451/08—Characterised by the use of graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives of such polymers grafted on to macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K3/00—Use of inorganic substances as compounding ingredients
    • C08K3/18—Oxygen-containing compounds, e.g. metal carbonyls
    • C08K3/20—Oxides; Hydroxides
    • C08K3/22—Oxides; Hydroxides of metals
    • C08K2003/2237—Oxides; Hydroxides of metals of titanium
    • C08K2003/2241—Titanium dioxide

Abstract

The present invention relates to the preparation methods of hydrogel, which is characterized in that the hydrophilic hydrogel is composed of the following components according to weight percent：Silicon-containing monomer：25~55%；Hydrophilic monomer：35~65%；Polyethyleneglycol diacrylate：1~3%；Crosslinking agent：1~2%；Initiator：1~2%；Moisturizer：5~10%.Hydrogel prepared by the present invention can directly be worn without post processings such as surface modifications.Preparation process is simple to operation, is suitble to large-scale production.

Description

The preparation method of hydrogel
Technical field
The present invention relates to a kind of preparation methods of hydrogel.
Background technology
, it is necessary to carry out moisturizing during contact lenses use, the contact lenses that common material makes cannot expire The wearing demand of sufficient people to improve the oxygen permeability of hydrogel, achievees the purpose that eyeglass is enable to wear overnight, researcher The silicone-hydrogel of high oxygen flow is capable of in research hotspot steering one after another.Silicone hydrogel material can combine organosilicon material The flexibility of high oxygen permeability and hydrogel material can meet consumer's comfort and the needs of continuously wearing, and eliminate because wearing Related symptoms caused by anoxic.Current many researchers are directed to silicon rubber or silicone-hydrogel surface hydrophilic modification, effect are good Good but process conditions are complicated, are not suitable for scale processing.
In view of drawbacks described above, it is necessary to propose a kind of preparation method of new hydrophilic hydrogel.
The content of the invention
The object of the present invention is to provide a kind of preparation methods of new hydrogel.
Technical scheme is as follows：
A kind of preparation method of hydrogel, which is characterized in that the hydrophilic hydrogel is according to weight percent, by with the following group It is grouped into：
Silicon-containing monomer：25~55%；
Hydrophilic monomer：35~65%；
Polyethyleneglycol diacrylate：1~3%；
Crosslinking agent：1~2%；
Initiator：1~2%；
Moisturizer：5~10%.
Further, the silicon-containing monomer is methyl-two (trimethylsiloxane group)-methyl propyl methyl acid Glyceride or methyl-two (trimethylsiloxane group)-methyl propyl methyl acid glyceride and methacryloxypropyl third The mixture of base three (trimethylsiloxy group) silane composition.
Further, the hydrophilic monomer is one in caprolactone monomer, trimethylene carbonate monomer, glycolide monomer Kind is a variety of.
Further, the crosslinking agent is styrene, a- methyl styrenes, acrylonitrile, acrylic acid, methacrylic acid, second Any one of dialdehyde, aziridine.
Further, the initiator is azodiisobutyronitrile.
A kind of preparation method of hydrophilic hydrogel, it is characterised in that：The moisturizer is glycerine, propylene glycol, sorbierite In one or more.
In the present invention and hydrophilic monomers content is high.The embodiment of the present invention can be by preparing the hydrophilic water with moisturizer Gel, anti-proteinosis performance is good, human eye comfortable wearing.And prepare silicone-hydrogel without surface be modified etc. post processings, can be straight Connect wearing.Preparation process is simple to operation, is suitble to large-scale production.
Specific embodiment
With reference to embodiment, the invention will be further described.
Specific embodiment formula：
Silicon-containing monomer：25~55%；
Hydrophilic monomer：35~65%；
Polyethyleneglycol diacrylate：1~3%；
Crosslinking agent：1~2%；
Surfactant：1~2%；
Moisturizer：5~10%.
Specifically preparation method is：
Hydrophilic monomer, silicon-containing monomer, polyethyleneglycol diacrylate are dispersed in moisturizing dosage form under agitation Into component A, crosslinking agent is formed into B component under agitation, B component and initiator are added in component A, in vacuum condition Lower formation gel layer, obtains hydrophilic hydrogel.
Embodiment 1
By-two (trimethylsiloxane group)-methyl propyl methyl acid glyceride of 25% methyl, 65% trimethylene Carbonate monomer, 3% polyethyleneglycol diacrylate, which are scattered in after stirring evenly in 5% glycerine, forms component A, by 2% Styrene forms B component under stiring, the azodiisobutyronitrile of B component and 1% is added in component A, under vacuum Gel layer is formed, obtains hydrophilic hydrogel.
Embodiment 2
By 55% methacryloxypropyl three (trimethylsiloxy group) silane, 35% glycolide monomer, 1% polyethylene glycol Diacrylate, which is scattered in after stirring evenly in 7% propylene glycol, forms component A, and 2% titanium dioxide is formed B under stiring The azodiisobutyronitrile of B component and 1% is added in component A, forms gel layer under vacuum by component, obtains hydrophilic Property hydrogel.
Embodiment 3
By-two (trimethylsiloxane group)-methyl propyl methyl acid glyceride of 42% methyl and methacryl Mixture, 44% trimethylene carbonate monomer, the 2% polyethylene glycol dipropyl of oxygen propyl group three (trimethylsiloxy group) silane composition Olefin(e) acid ester, which is scattered in after stirring evenly in 10% propylene glycol, forms component A, and 2% acrylonitrile is formed B component under stiring, The azodiisobutyronitrile of B component and 1% is added in component A, forms gel layer under vacuum, obtains hydrophily water-setting Glue.
The above is only the preferred embodiment of the present invention, is not intended to limit the invention, it is noted that for this skill For the those of ordinary skill in art field, without departing from the technical principles of the invention, can also make it is several improvement and Modification, these improvements and modifications also should be regarded as protection scope of the present invention.

Claims (6)

1. a kind of preparation method of hydrogel, which is characterized in that the hydrophilic hydrogel is according to weight percent, by following components Composition：
Silicon-containing monomer：25~55%；
Hydrophilic monomer：35~65%；
Polyethyleneglycol diacrylate：1~3%；
Crosslinking agent：1~2%；
Initiator：1~2%；
Moisturizer：5~10%.
2. a kind of preparation method of hydrogel according to claim 1, it is characterised in that：The silicon-containing monomer is first Base-two (trimethylsiloxane group)-methyl propyl methyl acid glyceride or methyl-two (trimethylsiloxane group)- The mixture of methyl propyl methyl acid glyceride and methacryloxypropyl three (trimethylsiloxy group) silane composition.
3. a kind of preparation method of hydrogel according to claim 1, it is characterised in that：The hydrophilic monomer is caprolactone One or more in monomer, trimethylene carbonate monomer, glycolide monomer.
4. a kind of preparation method of hydrogel according to claim 1, it is characterised in that：The crosslinking agent for styrene, Any one of a- methyl styrenes, acrylonitrile, acrylic acid, methacrylic acid, glyoxal, aziridine.
5. a kind of preparation method of hydrogel according to claim 1, it is characterised in that：The initiator is different for azo two Butyronitrile.
6. a kind of preparation method of hydrogel according to claim 1, it is characterised in that：The moisturizer is glycerine, third One or more in glycol, sorbierite.
CN201611054917.5A 2016-11-25 2016-11-25 The preparation method of hydrogel Pending CN108102049A (en)

Priority Applications (1)

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CN201611054917.5A CN108102049A (en) 2016-11-25 2016-11-25 The preparation method of hydrogel

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201611054917.5A CN108102049A (en) 2016-11-25 2016-11-25 The preparation method of hydrogel

Publications (1)

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CN108102049A true CN108102049A (en) 2018-06-01

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113019271A (en) * 2020-12-18 2021-06-25 张家港市济泽化工环保科技有限公司 Formaldehyde-removing hydrogel and preparation method thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102964532A (en) * 2012-11-29 2013-03-13 海昌隐形眼镜有限公司 Organic silicon hydrogel material of contact lenses and preparation method thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102964532A (en) * 2012-11-29 2013-03-13 海昌隐形眼镜有限公司 Organic silicon hydrogel material of contact lenses and preparation method thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113019271A (en) * 2020-12-18 2021-06-25 张家港市济泽化工环保科技有限公司 Formaldehyde-removing hydrogel and preparation method thereof

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Application publication date: 20180601

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