CN108096456A - A kind of Chinese medicine composition for treating few azoospermia and preparation method thereof - Google Patents

A kind of Chinese medicine composition for treating few azoospermia and preparation method thereof Download PDF

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CN108096456A
CN108096456A CN201711449723.XA CN201711449723A CN108096456A CN 108096456 A CN108096456 A CN 108096456A CN 201711449723 A CN201711449723 A CN 201711449723A CN 108096456 A CN108096456 A CN 108096456A
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chinese medicine
medicine composition
treatment
azoospermia
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朱友应
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8969—Polygonatum (Solomon's seal)
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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Abstract

The invention belongs to technical field of traditional Chinese medicines, more particularly to a kind of Chinese medicine composition for treating few azoospermia and preparation method thereof, invent the medicament prepared, pass through certain raw material composition and ratio, so that obtained medicament has preferable therapeutic effect, after treatment 70 days, a grades of sperm ratios are up to more than 22%, a+b grades of sperm ratios are up to more than 60%, sperm motility is up to more than 68%, sperm concentration is up to more than 35%, to the high efficiency of few azoospermia patient up to more than 98%, and is that the pregnancy rate of spouse is up to more than 70%.

Description

A kind of Chinese medicine composition for treating few azoospermia and preparation method thereof
Technical field
The invention belongs to technical field of traditional Chinese medicines more particularly to a kind of Chinese medicine composition for treating few azoospermia and its preparation sides Method.
Background technology
In recent years, sterility incidence substantially rises, it has also become influences the global problem of couple and social stability.
As male is subject to the environment of continuous increased life stress, unsound life style, getting worse in recent years The influence of the factors such as pollution, the incidence of male sterility raise year by year, and sperm quality is principal element extremely.Male sterility Sexual dysfunction and normal two class of sexual function can be clinically divided into, and sexual function normality infertility can refer to according to semen analysis Mark is further divided into oligospermatism, asthénospermie, azoospermia, asthenospermia disease and sperm number normality infertility.Few weak essence Disease is the principal element of male sterility, is mainly shown as that the number of sperm and/or vigor are less than normal reproduction ability in sperm A kind of disease.The World Health Organization (World healthorganization, WHO) is by sperm concentration<20×106/ ml is few Sperm disease, a grades of sperm motility<25% or a+b grades of sperm<50% is asthénospermie.It is often low with sperm motility clinically to lack sperm Under exist simultaneously, referred to as azoospermia less.Few azoospermia pathogenic factor is still not clear, and pathogenesis is more complicated, and doctor trained in Western medicine is more to this Using treatments such as hormone, nutrient drugs, curative effect is unsatisfactory.
The content of the invention
The present invention is in order to solve the above technical problems, provide a kind of Chinese medicine composition for treating few azoospermia and its preparation Method.
It is realized particular by following technical scheme：
A kind of Chinese medicine composition for treating few azoospermia, including following mass parts raw material：50-80 parts of Semen Cuscutae, the fleece-flower root 50-80 parts, 20-50 parts of grapeleaf anemone root, 10-30 parts of sealwort, 10-30 parts of Herba Epimedii, 10-30 parts of thizoma curculiginis, 10-30 parts of pilose antler, benefit 8-25 parts of Brittle Falsepimpernel Herb, 10-25 parts of radix bupleuri, 10-25 parts of radix scutellariae, 10-20 parts of selfheal, 8-25 parts of teasel root, 5-20 parts of FRUCTUS TOOSENDAN, Radix Paeoniae Alba 5-20 parts, 5-20 parts of sweet wormwood, 5-20 parts of Radix Glycyrrhizae.
Further, the Chinese medicine composition of the few azoospermia of the treatment, including following mass parts raw material：Semen Cuscutae 60-65 Part, 60-65 parts of the fleece-flower root, 30-40 parts of grapeleaf anemone root, 15-25 parts of sealwort, 15-25 parts of Herba Epimedii, 15-25 parts of thizoma curculiginis, pilose antler 15-25 parts, 12-18 parts of motherwort, 12-18 parts of radix bupleuri, 12-18 parts of radix scutellariae, 12-18 parts of selfheal, 12-18 parts of teasel root, Bell's 8-15 parts sub-, 8-15 parts of Radix Paeoniae Alba, 8-15 parts of sweet wormwood, 7-12 parts of Radix Glycyrrhizae.
Further, the Chinese medicine composition of the few azoospermia of the treatment, can be prepared into decoction, paste, tablet, electuary.
Further, the decoction weighs each component materials or by each component materials co-grinding, adds in 3-5 times clear Water, decocts 3-5h, and filtering both obtained.
Further, the paste weighs each component materials mixing, crushes, adds in the volume of 2-3 times of mixed-powder quality Fraction is 40-60% ethanol solutions, ultrasonic extraction 30-40min or decoction 2-3h, and filtering, filtrate decompression, which flows back, recycles ethyl alcohol, obtains Residual solution, residual solution drying be made water content be 1-1.2% paste to get.
Further, the tablet will weigh each component materials mixing, crush, and add in the body of 2-3 times of mixed-powder quality Fraction is 40-60% ethanol solutions, ultrasonic extraction 30-40min or decoction 2-3h, and filtering, filtrate decompression, which flows back, recycles ethyl alcohol, Residual solution, residual solution drying is made water content be 10-12% medicinal extract, add in filler, adhesive, disintegrant, lubricant, Mixing, film-making to get；
The filler is starch, Icing Sugar, dextrin are according to quality 0.5-1:0.6-0.8:1-1.2 it mixes；Bonding Agent is one in sodium carboxymethylcellulose, hydroxypropyl cellulose, methylcellulose, ethyl cellulose, hydroxypropyl methyl cellulose Kind is several；Disintegrant for crosslinked polypropylene alkene pyrrolidone, sodium carboxymethyl starch, one kind in croscarmellose sodium or It is several；Lubricant is one or more of magnesium stearate, Macrogol 4000, Macrogol 6000, talcum powder.
Further, the electuary will weigh each component materials mixing, crush, it is clear to add in 3-4 times of mixed-powder quality Water decocts 4-6h, filtering, and dried filtrate obtains the medicinal extract of 10-12%, add in auxiliary material mixing granulation, it is dry both, granule it is auxiliary Expect identical with used in tablet.
Advantageous effect by Clinical Application Analysis, takes medicament prepared by the present invention, forms and match somebody with somebody by certain raw material Than so that obtained medicament has preferable therapeutic effect, and after treatment 70 days, a grades of sperm ratios are up to more than 22%, a+ B grades of sperm ratios are up to more than 60%, and sperm motility is up to more than 68%, and sperm concentration is up to more than 35%, to weak essence less The high efficiency of disease patient is that the pregnancy rate of spouse is up to more than 70% up to more than 98%.
In conclusion drug prepared by the present invention has the work(of kidney-tonifying sperm-generating, wither so as to promote Sperm specific enzyme, reduce sperm Rate is died, improves sperm motility, achievees the purpose that the few azoospermia for the treatment of.
Specific embodiment
The specific embodiment of the present invention is described in further detail below, but the invention is not limited in these realities Mode is applied, it is claimed to still fall within the claims in the present invention for any improvement or replacement on the present embodiment essence spirit Scope.
Embodiment 1
A kind of Chinese medicine composition for treating few azoospermia, including following mass parts raw material：Semen Cuscutae 60g, fleece-flower root 60g, Grapeleaf anemone root 30g, sealwort 15g, Herba Epimedii 15g, thizoma curculiginis 15g, pilose antler 15g, motherwort 12g, radix bupleuri 12g, radix scutellariae 12g, summer are withered Careless 12g, teasel root 12g, FRUCTUS TOOSENDAN 8g, Radix Paeoniae Alba 8g, sweet wormwood 8g, Radix Glycyrrhizae 7g.
The Chinese medicine composition of the described few azoospermia for the treatment of, is prepared into decoction, weigh each component materials or by it is each into Divide raw material mixed powder broken, add in 3 times of clear water, decoct 3h, filtering both obtains.
Embodiment 2
A kind of Chinese medicine composition for treating few azoospermia, including following mass parts raw material：Semen Cuscutae 63g, fleece-flower root 63g, Grapeleaf anemone root 35g, sealwort 20g, Herba Epimedii 20g, thizoma curculiginis 20g, pilose antler 20g, motherwort 15g, radix bupleuri 15g, radix scutellariae 15g, summer are withered Careless 15g, teasel root 15g, FRUCTUS TOOSENDAN 10g, Radix Paeoniae Alba 10g, sweet wormwood 10g, Radix Glycyrrhizae 10g.
The Chinese medicine composition of the few azoospermia of the treatment, prepares paste making agent, weighs each component materials mixing, crushes, adds Enter the volume fraction of 2 times of mixed-powder quality for 40% ethanol solution, ultrasonic extraction 30min or decoction 2h, filtering, filtrate decompression Reflux recycling ethyl alcohol, obtains residual solution, residual solution drying be made the paste that water content is 1% to get.
Embodiment 3
A kind of Chinese medicine composition for treating few azoospermia, including following mass parts raw material：Semen Cuscutae 65g, fleece-flower root 65g, Grapeleaf anemone root 40g, sealwort 25g, Herba Epimedii 25g, thizoma curculiginis 25g, pilose antler 25g, motherwort 18g, radix bupleuri 18g, radix scutellariae 18g, summer are withered Careless 18g, teasel root 18g, FRUCTUS TOOSENDAN 15g, Radix Paeoniae Alba 15g, sweet wormwood 15g, Radix Glycyrrhizae 12g.
The Chinese medicine composition of the few azoospermia of the treatment, prepares piece agent, will weigh each component materials mixing, crush, The volume fraction of 2 times of mixed-powder quality is added in as 40% ethanol solution, ultrasonic extraction 30min or decoction 2h, filtering, filtrate subtract It pushes back and flows back to receipts ethyl alcohol, obtain residual solution, the medicinal extract that water content is 10% is made in residual solution drying, adds in filler, adhesive, collapses Solve agent, lubricant, mixing, film-making to get；
The additive of tablet, filler is starch, Icing Sugar, dextrin are according to quality 0.5:0.6:1 mixes；
Adhesive is sodium carboxymethylcellulose；
Disintegrant is crosslinked polypropylene alkene pyrrolidone；
Lubricant is magnesium stearate.
The formula composition of embodiment 4-11 is as shown in table 1, and preparation method is to be prepared into decoction.
1 embodiment 4-11 composition of raw materials tables (g) of table
Shown in the formula composition of embodiment 12- embodiments 19 and table 2, its preparation method is to be prepared into decoction.
The formula composition (g) of 2 embodiment 12- embodiments 19 of table
Embodiment 20
A kind of Chinese medicine composition for treating few azoospermia, including following mass parts raw material：Semen Cuscutae 50g, fleece-flower root 50g, Grapeleaf anemone root 20g, sealwort 10g, Herba Epimedii 10g, thizoma curculiginis 10g, pilose antler 10g, motherwort 8g, radix bupleuri 10g, radix scutellariae 10g, selfheal 10g, teasel root 8g, FRUCTUS TOOSENDAN 5g, Radix Paeoniae Alba 5g, sweet wormwood 5g, Radix Glycyrrhizae 5g, embodiment 20 are that medicament is prepared into decoction.
Embodiment 21
A kind of Chinese medicine composition for treating few azoospermia, including following mass parts raw material：Semen Cuscutae 80g, fleece-flower root 80g, Grapeleaf anemone root 50g, sealwort 30g, Herba Epimedii 30g, 30g parts of thizoma curculiginis, pilose antler 30g, motherwort 25g, radix bupleuri 25g, radix scutellariae 25g, summer Withered grass 20g, teasel root 25g, FRUCTUS TOOSENDAN 20g, Radix Paeoniae Alba 20g, sweet wormwood 20g, Radix Glycyrrhizae 20g, embodiment 21 are to be prepared into decoction.
Experimental example
1st, 250 cleaning grade male Kunming small white mouses are chosen, weight is randomly divided into 25 groups in 18-20g, every group 10, point For embodiment 1-21 groups, model group, control group, blank group, western medicine group, control group adds taste soup (basic using five-seed Yanzong Side:Semen Cuscutae 30g, fruit of Chinese wolfberry 20g, raspberry 15g, Schisandra chinensis 10g, mulberry fruit 20g, fruit of glossy privet 18g, plantain seed 10g, excessive sheep Leaves of pulse plants 15g, Herba Cistanches 12g, thizoma curculiginis 12g, Radix Astragali 12g, Radix Salviae Miltiorrhizae 18g, Radix Angelicae Sinensis 10g, radix paeoniae rubrathe 12g), western medicine group takes undecanoic acid Testosterone capsule and pill, (sieve lacks ripple " strengthening the essence side " and adjusts Ca~(2+) passage improvement Acu-point plaster therapy not the method for reference literature report Educate the department of traditional Chinese medicine institute of research [D] China of model sperm quality, 2009.) therapeutic effect of each embodiment of measurement.
Dosage：Administration consumes 15g crude drugs according to every kilogram of mouse and calculates daily, feeds at twice daily.
Experimental method：After adaptability raises and train 5 days, blank group presses 60mg/kg weight intraperitoneal injection of saline, embodiment 1- 21, model group, control group, western medicine group, embodiment 1-21 by 60mg/kg weight be injected intraperitoneally ring phosphorus phthalein amine, once a day, Continuous 5 days, start within the 6th day medicine feed agent, blank group, control group are physiological saline to mouse, and dosage is that (wherein ml is 0.019aml Mouse weight), twice daily, continuous 34 days, start to measure the index of each experimental mice, each experimental group of measurement result is surveyed Amount 3 times, averages.
As a result：Naive mice body weight gradually increases, and chaeta is glossy, and activity is quick.Model group mouse opened from the 6th day The sings and symptomses such as the beginning gradually appears apathetic, movable reductions, aversion to cold, chaeta are sparse, matt, urine amount increases and in It is similar to cure the disease performance of " kidney deficiency ", embodiment 1-3,20, the 21 mouse mouse spirit after medicine feed 20 days improves, chaeta Gloss is gradually appeared, then effect is poor for remaining embodiment, and improvement situation is not as good as embodiment 1-3, and 20,21.
3 mouse test results (× 10 of table6/ml)
A grades of sperm concentrations B grades of sperm concentrations C grades of sperm concentrations Sperm gross density Sperm motility Sperm motility rate
Embodiment 1 0.39 0.28 1.98 5.04 19.21 76.25
Embodiment 2 0.40 0.30 1.86 5.12 20.22 78.26
Embodiment 3 0.37 0.30 1.93 5.23 21.03 76.35
Embodiment 4 0.32 0.25 1.24 2.13 13.87 71.21
Embodiment 5 0.28 0.24 1.20 2.04 12.45 62.35
Embodiment 6 0.30 0.21 1.23 2.05 13.21 65.32
Embodiment 7 0.31 0.22 1.02 2.25 10.40 60.12
Embodiment 8 0.22 0.26 1.30 2.07 12.16 63.54
Embodiment 9 0.25 0.20 0.98 2.18 10.55 60.87
Embodiment 10 0.27 0.23 1.08 2.20 11.32 65.36
Embodiment 11 0.24 0.20 1.12 2.02 12.33 68.25
Embodiment 12 0.25 0.21 0.95 2.11 10.64 65.28
Embodiment 13 0.30 0.25 1.25 2.20 13.17 70.31
Embodiment 14 0.26 0.20 1.14 2.15 10.56 62.21
Embodiment 15 0.21 0.17 0.89 2.02 12.24 68.31
Embodiment 16 0.27 0.20 1.20 2.25 10.14 58.69
Embodiment 17 0.30 0.23 1.20 2.19 12.05 70.18
Embodiment 18 0.24 0.19 0.85 2.09 9.63 60.45
Embodiment 19 0.27 0.20 1.15 2.04 10.37 65.64
Embodiment 20 0.35 0.26 1.57 4.15 18.24 72.43
Embodiment 21 0.33 0.26 1.45 4.20 18.23 73.43
Blank group 0.42 0.33 2.04 6.13 14.87 76.21
Model group 0.15 0.16 0.53 1.73 42.53 33.65
Control group 0.30 0.24 1.30 3.35 66.85 70.21
Western medicine group 0.28 0.22 1.26 3.08 17.21 68.18
After ring phosphorus phthalein amine modeling, model group mouse sperm density, vigor and motility rate are remarkably decreased compared with naive mice, can To think to make the success of mouse infertility model, apathetic, the movable reduction occurred in an experiment with reference to mouse, aversion to cold, chaeta It is sparse, matt, it is believed that made model substantially conforms to sterile disease caused by the traditional Chinese medical science " kidney deficiency ".By feeding this to mouse The medicament of invention finds that after the medicament of the present invention is taken different degrees of improvement occurs in the semen quality of mouse.By matching somebody with somebody Side and dose screening experiment show that embodiment 1-3, embodiment 20, embodiment 21 are preferable to the sperm improvement of mouse.
2nd, clinical practice
Male's aspermia or oligospermia refers to Semen routione sperm quantity less than 20 × 106/m1.Azoospermia refers to that sperm is lived in Semen routione Power is low, and a grades of sperms moved are less than 25% or (a grades+b grades) of the sperm of propulsion is less than 50%, because of mankind's spermatogonium Growing to the cycle of mature sperm needs 64-72d.Age 25-25 Sui is selected, sexual life is normal, and wife's side fertility checks normal, wedding It does not take any contraceptives latter year and prestige is pregnant, there is the patient of oligoasthenospermia disease for treatment object, choose 150, divide equally For 3 groups, experimental group 1 takes the medicament of the preparation of embodiment 2, and experimental group 2 takes the medicament of the preparation of embodiment 9, and experimental group 3 takes reality The medicament of the preparation of example 16 is applied, Time of Administration is 70 days, and the amount that embodiment provides is 1 pair of medicament, is divided to two days and takes.Reference literature report (Yu Chao, He Xiaofeng, Feng Yigeng wait the profound coltfoal capsule Combined with Chinese Herbal treatment kidney yang deficiency male's asthénospermie of compounds to the method in road Clinical observation [J] China andrology magazine, 2016,30 (1):46-48.), statistical is carried out to each experimental group treatment Analysis, the results are shown in Table 3.
Reference《The inspection of Infertile couples standard and diagnosis handbook》And《Study of tcm new drug guideline of clinical investigations》In starve Standard is evaluated.Effectively：Spouse becomes pregnant；It is effective：Though do not become pregnant, after treatment asthénospermie and sperm motility it is normal (a+b >= 50% or a >=25%, sperm motility >=60%)；Effectively：Sperm motility makes moderate progress (a+b>30% or a>30%, essence Son deposits activity ratio 30%)；It is invalid：Sperm motility improves≤30% or unchanged before and after treatment.
4 Clinical practice Comparison of therapeutic of table
Group Recovery from illness It is effective Effectively It is invalid Total effective rate %
Embodiment 2 35 10 4 1 98%
Embodiment 9 7 9 15 19 62%
Embodiment 16 5 8 17 20 60%
Table 5 treats preceding routine index of semen
A grades of sperms A+b grades of sperms Sperm motility Sperm concentration × 106/ml
Embodiment 2 17.23±3.45 32.45±7.81 40.45±5.52 22.57±8.52
Embodiment 9 17.03±4.67 33.50±5.14 42.31±6.72 23.57±9.03
Embodiment 16 16.75±5.23 34.76±6.05 42.61±8.73 22.45±6.72
Routine index of semen after table 6 is treated
A grades of sperm % A+b grades of sperm % Sperm motility % Sperm concentration × 106/ml
Embodiment 2 28.67±5.78 65.78±6.38 78.36±10.32 42.68±6.87
Embodiment 9 19.34±5.21 55.29±6.78 59.52±6.56 30.27±8.53
Embodiment 16 20.34±6.24 53.39±5.62 61.37±3.89 33.59±6.87
On the basis of animal model test, 16 3 embodiment 2, embodiment 9, embodiment prescriptions is selected to carry out clinic and are controlled It treats, during the entire course for the treatment of, all treatment objects do not occur any adverse reaction.By Clinical Application Analysis, take Medicament prepared by embodiment 2, after treatment 70 days, a grades of sperm ratios are up to more than 22%, a+b grades of sperm ratios and are up to More than 60%, sperm motility is up to more than 68%, and sperm concentration is up to more than 35%, to the high efficiency of few azoospermia patient Up to more than 98%, and it is that the pregnancy rate of spouse is up to more than 70%.Embodiment 9 since the composition of formula is different, embodiment 16 by It is different in the proportioning of each component, therefore cause its curative effect difference farther out.
In conclusion drug prepared by the present invention has the work(of kidney-tonifying sperm-generating, wither so as to promote Sperm specific enzyme, reduce sperm Rate is died, improves sperm motility, achievees the purpose that the few azoospermia for the treatment of.

Claims (7)

1. a kind of Chinese medicine composition for treating few azoospermia, which is characterized in that including following mass parts raw material：Semen Cuscutae 50-80 Part, 50-80 parts of the fleece-flower root, 20-50 parts of grapeleaf anemone root, 10-30 parts of sealwort, 10-30 parts of Herba Epimedii, 10-30 parts of thizoma curculiginis, pilose antler 10-30 parts, 8-25 parts of motherwort, 10-25 parts of radix bupleuri, 10-25 parts of radix scutellariae, 10-20 parts of selfheal, 8-25 parts of teasel root, FRUCTUS TOOSENDAN 5-20 parts, 5-20 parts of Radix Paeoniae Alba, 5-20 parts of sweet wormwood, 5-20 parts of Radix Glycyrrhizae.
2. the Chinese medicine composition of the few azoospermia for the treatment of as described in claim 1, which is characterized in that azoospermia is lacked in the treatment Chinese medicine composition, including following mass parts raw material：60-65 parts of Semen Cuscutae, 60-65 parts of the fleece-flower root, 30-40 parts of grapeleaf anemone root, 15-25 parts of sealwort, 15-25 parts of Herba Epimedii, 15-25 parts of thizoma curculiginis, 15-25 parts of pilose antler, 12-18 parts of motherwort, 12-18 parts of radix bupleuri, 12-18 parts of radix scutellariae, 12-18 parts of selfheal, 12-18 parts of teasel root, 8-15 parts of FRUCTUS TOOSENDAN, 8-15 parts of Radix Paeoniae Alba, 8-15 parts of sweet wormwood, Radix Glycyrrhizae 7-12 parts.
3. the Chinese medicine composition of the few azoospermia for the treatment of as described in claim 1, which is characterized in that azoospermia is lacked in the treatment Chinese medicine composition, decoction, paste, tablet, electuary can be prepared into.
4. the Chinese medicine composition of the few azoospermia for the treatment of as claimed in claim 3, which is characterized in that the decoction weighs each Component materials or by each component materials co-grinding, add in 3-5 times of clear water, decoct 3-5h, filtering both must.
5. the Chinese medicine composition of the few azoospermia for the treatment of as claimed in claim 3, which is characterized in that the paste weighs each Component materials mixing crushes, and adds in the volume fraction of 2-3 times of mixed-powder quality as 40-60% ethanol solutions, ultrasonic extraction 30-40min decocts 2-3h, filtering, and filtrate decompression reflux recycling ethyl alcohol obtains residual solution, and residual solution drying is made water content and is The paste of 1-1.2% to get.
6. the Chinese medicine composition of the few azoospermia for the treatment of as claimed in claim 3, which is characterized in that the tablet will weigh Each component materials mixing crushes, and adds in the volume fraction of 2-3 times of mixed-powder quality as 40-60% ethanol solutions, ultrasonic extraction 30-40min decocts 2-3h, filtering, and filtrate decompression reflux recycling ethyl alcohol obtains residual solution, and residual solution drying is made water content and is The medicinal extract of 10-12%, add in filler, adhesive, disintegrant, lubricant, mixing, film-making to get.
7. the Chinese medicine composition of the few azoospermia for the treatment of as claimed in claim 3, which is characterized in that the electuary will weigh Each component materials mixing crushes, and adds in 3-4 times of mixed-powder quality clear water, decocts 4-6h, filtering, dried filtrate obtains 10-12% Medicinal extract, add in auxiliary material mixing granulation, it is dry both.
CN201711449723.XA 2017-12-27 2017-12-27 A kind of Chinese medicine composition for treating few azoospermia and preparation method thereof Pending CN108096456A (en)

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1900372B1 (en) * 2006-09-15 2013-12-04 Luay Rashan Composition for enhancing male fertility

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1900372B1 (en) * 2006-09-15 2013-12-04 Luay Rashan Composition for enhancing male fertility

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
尹艳茹等: "生精种玉汤治疗肾虚型少、弱精症的安全性和有效性探究", 《辽宁中医杂志》 *

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Application publication date: 20180601