CN108091542A - A kind of effectively ionized method of High-Field Asymmetric Waveform Ion Mobility Spectrometer sample - Google Patents
A kind of effectively ionized method of High-Field Asymmetric Waveform Ion Mobility Spectrometer sample Download PDFInfo
- Publication number
- CN108091542A CN108091542A CN201611036618.9A CN201611036618A CN108091542A CN 108091542 A CN108091542 A CN 108091542A CN 201611036618 A CN201611036618 A CN 201611036618A CN 108091542 A CN108091542 A CN 108091542A
- Authority
- CN
- China
- Prior art keywords
- ion mobility
- sample
- asymmetric waveform
- pole plate
- mobility spectrometry
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/10—Ion sources; Ion guns
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
Abstract
A kind of effectively ionized method of High-Field Asymmetric Waveform Ion Mobility Spectrometer sample, High-Field Asymmetric Waveform Ion Mobility Spectrometer are to carry out ion differentiation using difference of the mobility of sample ions itself under high electric field and existing fringing field.Not only ionized region will be entered but also for carrying sample for the sample ions for ionizing generation to be divided into two-way source of the gas in the carrier gas of migration area lateral transport arrival detection zone originally.Carrier gas can be adjusted to required flow and bring sample into ionized region as needed, transmit gas without taking into account the big flow that sample ions transmission needs in migration area, extend residence time of the sample in ionized region so that sample can be adequately ionized.Sample ions after being adequately ionized enter Disengagement zone by transmitting airborne band, and arrival detection zone is detected after carrying out separation.Therefore this method does not use electric field means that can both increase the ionizing efficiency of sample, the present invention is simple and practical, at low cost, applied widely on the premise of taking into account positive and negative ion and can detect.
Description
Technical field
The present invention relates to type ion mobility spectrometry technologies, are specifically a kind of High-Field Asymmetric Waveform Ion Mobility Spectrometer sample
The effectively ionized method of product.
Background technology
Type ion mobility spectrometry (Differential Ion Mobility Spectrometry, DMS), also referred to as
High-Field asymmetric waveform ion mobility spectrometry (Field-Asymmetric Waveform Ion Mobility Spectrometry,
FAIMS), it is that a kind of difference based on High-Field and the lower ionic mobility of low field effect carries out separated novel ion migration spectrum skill
Art, this method is proposed earliest by Gorshkov in nineteen eighty-two, until 1990s initial stages, just by Krylov and Nazarov et al. progress
Experimental verification.Flat and drum type brake wherein flat-type ion mobility spectrum operation principle can be divided into according to the difference of structure
Mainly it is made of ionized region, Disengagement zone and detection zone.The Disengagement zone of flat DMS is made of two pieces of parallel electrode plates, wherein
One flat plate on add asymmetric waveform rf electric field (Dispersion Voltage, DV), another piece ground connection.
High-Field asymmetric waveform ion mobility spectrometry is to carry out ion isolation in difference just off field using ionic mobility
's.Sample enters ionized region by carrier gas band, and the sample ions being then ionized enter migration area.Migration area be generally two pieces it is parallel
Tablet.The rf electric field of asymmetric waveform, another piece of ground connection are added on one flat plate wherein.Ion exists in migration area
The movement shaken up and down can be done under the action of high-frequency electric field on the direction vertical with carrier gas direction.Due in height field ion
Mobility is different, and in each cycle of high-frequency electric field, ion can all generate a displacement in vertical direction, and final ion is got to
It falls into oblivion and knocks out on pole plate.If applying a matched offset voltage on high-frequency electric field, offset ion and generate y under asymmetric field
The displacement in direction enables ion to reach detection pole by drift region.By being swept within the specific limits to offset voltage
It retouches, it is possible to so that different sample ions reach detection pole under specific offset voltage by migration area, realize the detection of sample.
Achieve the purpose that selective enumeration method sample by applying specific offset voltage.
High-Field asymmetric waveform ion mobility spectrometry is as the separate analytical technique under a kind of atmospheric pressure, due to having spirit
The advantages that sensitivity is high, and detection speed is fast, and instrument and equipment is simple and is easily achieved on-line analysis and detection, is widely used to state
Soil, such as public safety field, chemical warfare agent, drugs raid the Site Detection with explosive.In recent years, with High-Field asymmetrical wave
The development of shape Ion mobility spectrometry, ion mobility spectrometry is in fields such as large biological molecule analysis, environmental monitoring and process control
Also applied, and scope also expands constantly.But carrier gas used in High-Field asymmetric waveform ion mobility spectrometry at present
Often not only enter ionized region but also for carrying sample for the sample ions of generation will to be ionized in the arrival inspection of migration area lateral transport
Survey area.Bottom crown spacing is smaller on High-Field Asymmetric Waveform Ion Mobility Spectrometer, when sample passes through ionized region under certain flow rate
Linear velocity is larger, and shorter in the ionized region residence time, ionizing efficiency substantially reduces.
The content of the invention
A kind of effectively ionized method of High-Field Asymmetric Waveform Ion Mobility Spectrometer sample of the present invention.
A kind of effectively ionized method of High-Field Asymmetric Waveform Ion Mobility Spectrometer sample, High-Field asymmetric waveform Ion transfer
Spectrometer includes：High-Field asymmetric waveform ion mobility spectrometry migrates the top crown and bottom crown of pole plate, tabular top crown and lower pole
Plate is parallel and is oppositely arranged, by migrate above and below the separation electrode set on pole plate and receiving electrode respectively at upper and lower pole plate it
Between formed migration area, detection zone；
Sample carries the ion after ionization source ionizes by carrier gas and is carried jointly into Disengagement zone by carrier gas and transmission gas, real
Detection zone is reached after row separation to be detected, tail gas and neutral molecule are discharged by exhaust gas.
Separation electrode on top crown is applied with asymmetric radio-frequency voltage and direct current compensation voltage, the separation electricity on bottom crown
Pole is grounded, and forms the Disengagement zone of High-Field asymmetric waveform ion mobility spectrometry.
High-Field asymmetric waveform ion mobility spectrometry migrates the top crown and bottom crown of pole plate, parallel and between being oppositely arranged
Compartment away from material can be PEEK, stainless steel, glass etc. have certain degree of hardness material.
The insulating materials used of High-Field asymmetric waveform ion mobility spectrometry migration pole plate can be ceramics, glass, asphalt mixtures modified by epoxy resin
Fat etc. can keep the material of flatness within the specific limits.
Ionization source selected by High-Field asymmetric waveform ion mobility spectrometry can be nickel source, ultraviolet lamp ionization source or corona
The ionization source of the ionizable sample such as discharge ionization source.
Sample brings ionized region by carrier gas, and the sample ions for ionizing generation bring migration area by carrier gas again, in radio-frequency voltage
With under the collective effect of offset voltage, object ion reach detecting electrode, so as to achieve the purpose that ion isolation.Carrier gas is often
Not only ionized region was entered but also for carrying sample for the sample ions of generation will to be ionized in migration area lateral transport arrival detection zone.
Bottom crown spacing is smaller on High-Field Asymmetric Waveform Ion Mobility Spectrometer, linear velocity when sample passes through ionized region under certain flow rate
Larger, shorter in the ionized region residence time, ionizing efficiency substantially reduces.
It is an advantage of the invention that：
A kind of effectively ionized method of High-Field Asymmetric Waveform Ion Mobility Spectrometer sample of the present invention, exactly will both use originally
In carrier band sample enter ionized region again for will ionize generate sample ions migration area lateral transport arrival detection zone load
Qi leel is into two-way source of the gas, and for carrying the carrier gas that sample enters ionized region, another way source of the gas is used to that generation will to be ionized source of the gas all the way
Sample ions migration area lateral transport reach detection zone transmission gas.Carrier gas can be adjusted to required flow by sample as needed
It brings ionized region into, transmits gas without taking into account the big flow that sample ions transmission needs in migration area, extend sample and ionizing
The residence time in area so that sample can be adequately ionized.Sample ions after being adequately ionized enter Disengagement zone by transmitting airborne band,
Arrival detection zone is detected after carrying out separation.Therefore this method does not use on the premise of taking into account positive and negative ion and can detect
Electric field means can both increase the ionizing efficiency of sample, and the present invention is simple and practical, at low cost, applied widely.
Description of the drawings
Fig. 1 is a kind of structure diagram of the effectively ionized method of High-Field Asymmetric Waveform Ion Mobility Spectrometer sample, and 1 carries
Gas, 2 transmission gas, 3 High-Field asymmetric waveform ion mobility spectrometries migrate the top crown of pole plate, 4 High-Field asymmetric waveform Ion transfers
The bottom crown of spectrum migration pole plate, 5 ionization sources, 6 separation electrodes, 7 receiving electrodes, 8 exhaust gas.
Fig. 2 be with independent carrier gas and carrier gas with transmit qi leel from when measured acetone change in signal strength figure.
Specific embodiment
Shown in please referring to Fig.1.
High-Field asymmetric waveform ion mobility spectrometry migrates the top crown 3 of pole plate and bottom crown 4, and tabular top crown 3 is under
Pole plate 4 is parallel and is oppositely arranged, by migrating the separation electrode 6 set on pole plate and receiving electrode 7 above and below respectively at upper and lower
Migration area, detection zone are formed between pole plate；
Separation electrode on top crown is applied with asymmetric radio-frequency voltage and direct current compensation voltage, the separation electricity on bottom crown
Pole is grounded, and forms the Disengagement zone of High-Field asymmetric waveform ion mobility spectrometry, and sample is carried by carrier gas 1 after ionization source 5 ionizes
Ion by carrier gas 1 and transmission gas 2, carrier band into Disengagement zone, carries out reaching detection zone after separation and be detected jointly, tail gas and
Neutral molecule is discharged by exhaust gas 8, is finally reached the testing goal of sample.
High-Field asymmetric waveform ion mobility spectrometry migrates the top crown 3 of pole plate and bottom crown 4, parallel and be oppositely arranged
Compartment away from material can be PEEK, stainless steel, glass etc. have certain degree of hardness material.
The insulating materials used of High-Field asymmetric waveform ion mobility spectrometry migration pole plate can be ceramics, glass, asphalt mixtures modified by epoxy resin
Fat etc. can keep the material of flatness within the specific limits.
When 80 DEG C, radio-frequency voltage 1000V of High-Field asymmetric waveform ion mobility spectrometry migration pole plate temperature, offset voltage model
It encloses for -9V~+3V, when acetone concentration is 20ppb, carrier gas flux 200ml/min, transmission gas (transmission gas) air-flow are 800ml/
It is identical in other conditions using this effectively ionized method of High-Field Asymmetric Waveform Ion Mobility Spectrometer sample under the conditions of min
Under the conditions of, the acetone signal detected is remarkably reinforced.
Claims (5)
1. a kind of effectively ionized method of High-Field Asymmetric Waveform Ion Mobility Spectrometer sample, High-Field asymmetric waveform ion mobility spectrometry
Instrument includes：
High-Field asymmetric waveform ion mobility spectrometry migrates the top crown (3) of pole plate and bottom crown (4), tabular top crown (3) and
Bottom crown (4) is parallel and is oppositely arranged, by migrating the separation electrode (6) set on pole plate and receiving electrode (7) above and below respectively
Migration area, detection zone are formed between upper and lower pole plate；
Sample carries the ion after ionization source (5) ionization by carrier gas (1) and is entered by carrier gas (1) and the common carrier band of transmission gas (2)
Disengagement zone, arrival detection zone is detected after carrying out separation, and tail gas and neutral molecule are discharged by exhaust gas (8)；
Separation electrode on top crown is applied with asymmetric radio-frequency voltage and direct current compensation voltage, and the separation electrode on bottom crown connects
Ground forms the Disengagement zone of High-Field asymmetric waveform ion mobility spectrometry.
2. type ion mobility spectrometry instrument according to claim 1, it is characterised in that：
High-Field asymmetric waveform ion mobility spectrometry migrates the top crown (3) of pole plate and bottom crown (4), parallel and be oppositely arranged, it
Between interval insulant can be PEEK, stainless steel, glass etc. have certain degree of hardness material in one or two or more kinds.
3. type ion mobility spectrometry instrument according to claim 1, it is characterised in that：
The insulating materials used of High-Field asymmetric waveform ion mobility spectrometry migration pole plate can be ceramics, glass, epoxy resin etc.
The one or two or more kinds in the material of flatness can be kept within the specific limits.
4. type ion mobility spectrometry instrument according to claim 1, it is characterised in that：
Ionization source (5) selected by High-Field asymmetric waveform ion mobility spectrometry can be nickel source, ultraviolet lamp ionization source or corona
One or two or more kinds in the ionization source of the ionizable sample such as discharge ionization source.
5. type ion mobility spectrometry instrument according to claim 1, it is characterised in that：
A pair of of pole plate of separation electrode is symmetrically arranged in migration pole plate above and below with respect in plane, forms separation electrode (6),
A pair of of pole plate of receiving electrode is symmetrically arranged in migration pole plate above and below with respect in plane, forms receiving electrode (7).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611036618.9A CN108091542A (en) | 2016-11-23 | 2016-11-23 | A kind of effectively ionized method of High-Field Asymmetric Waveform Ion Mobility Spectrometer sample |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611036618.9A CN108091542A (en) | 2016-11-23 | 2016-11-23 | A kind of effectively ionized method of High-Field Asymmetric Waveform Ion Mobility Spectrometer sample |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108091542A true CN108091542A (en) | 2018-05-29 |
Family
ID=62168633
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611036618.9A Pending CN108091542A (en) | 2016-11-23 | 2016-11-23 | A kind of effectively ionized method of High-Field Asymmetric Waveform Ion Mobility Spectrometer sample |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108091542A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109065435A (en) * | 2018-08-28 | 2018-12-21 | 山东省分析测试中心 | A kind of micro- ionization spray ion source difference ion mobility spectrometry and its application method |
| CN110596401A (en) * | 2019-09-11 | 2019-12-20 | 宁波盘福生物科技有限公司 | High-field asymmetric waveform ion mobility device and method for protein detection |
| CN110687192A (en) * | 2019-10-25 | 2020-01-14 | 湘潭大学 | Trace compound measuring device and measuring method thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1391912A2 (en) * | 1998-08-05 | 2004-02-25 | National Research Council of Canada | Apparatus and method for atmospheric pressure 3-dimensional ion trapping |
| CN102646571A (en) * | 2012-05-04 | 2012-08-22 | 中国科学院合肥物质科学研究院 | High-field asymmetric waveform ion mobility spectrometry (FAIMS) based on ion wind pumping systems |
| CN102945786A (en) * | 2012-11-09 | 2013-02-27 | 清华大学 | Flat-plate type high-field asymmetric waveform ion mobility spectrometer with noise reduction function |
| CN104538274A (en) * | 2014-12-31 | 2015-04-22 | 清华大学 | Separation voltage applying method for high-field asymmetric waveform ion mobility spectrometer |
| CN104716013A (en) * | 2013-12-13 | 2015-06-17 | 中国科学院大连化学物理研究所 | Novel high-field asymmetric ion mobility spectrometry device |
-
2016
- 2016-11-23 CN CN201611036618.9A patent/CN108091542A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1391912A2 (en) * | 1998-08-05 | 2004-02-25 | National Research Council of Canada | Apparatus and method for atmospheric pressure 3-dimensional ion trapping |
| CN102646571A (en) * | 2012-05-04 | 2012-08-22 | 中国科学院合肥物质科学研究院 | High-field asymmetric waveform ion mobility spectrometry (FAIMS) based on ion wind pumping systems |
| CN102945786A (en) * | 2012-11-09 | 2013-02-27 | 清华大学 | Flat-plate type high-field asymmetric waveform ion mobility spectrometer with noise reduction function |
| CN104716013A (en) * | 2013-12-13 | 2015-06-17 | 中国科学院大连化学物理研究所 | Novel high-field asymmetric ion mobility spectrometry device |
| CN104538274A (en) * | 2014-12-31 | 2015-04-22 | 清华大学 | Separation voltage applying method for high-field asymmetric waveform ion mobility spectrometer |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109065435A (en) * | 2018-08-28 | 2018-12-21 | 山东省分析测试中心 | A kind of micro- ionization spray ion source difference ion mobility spectrometry and its application method |
| CN110596401A (en) * | 2019-09-11 | 2019-12-20 | 宁波盘福生物科技有限公司 | High-field asymmetric waveform ion mobility device and method for protein detection |
| CN110687192A (en) * | 2019-10-25 | 2020-01-14 | 湘潭大学 | Trace compound measuring device and measuring method thereof |
| CN110687192B (en) * | 2019-10-25 | 2022-04-22 | 湘潭大学 | Trace compound measuring device and measuring method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101918827B (en) | Method and device for detection and identification of gases | |
| CN103650102B (en) | Ion migration spectrometer, include its gas analysis system and the method determining chemical race | |
| US9719963B2 (en) | High performance ion mobility spectrometer apparatus and methods | |
| CN103811266A (en) | Flat type differential ion mobility spectrometer capable of selectively detecting positive and negative ions | |
| CN108091542A (en) | A kind of effectively ionized method of High-Field Asymmetric Waveform Ion Mobility Spectrometer sample | |
| US8716655B2 (en) | Integrated ion separation spectrometer | |
| CN110108778B (en) | UV-FAIMS quantitative detection method for volatile organic compounds | |
| Borsdorf et al. | Atmospheric pressure chemical ionization studies of non-polar isomeric hydrocarbons using ion mobility spectrometry and mass spectrometry with different ionization techniques | |
| EP3201616A1 (en) | Duel mode ion mobility spectrometer | |
| CN102954995A (en) | Non-uniform electric field based ion mobility spectrometer | |
| CN102478542A (en) | Flat-type fully differential ion mobility spectrometry | |
| CN102683151A (en) | Chemical ionization mass spectrometer for selectively controlling reaction ions | |
| CN105632874A (en) | DC non-uniform electric field ion migration tube | |
| CN105319284B (en) | A kind of method for combined use of gas-chromatography and ion mobility spectrometry | |
| CN104716013A (en) | Novel high-field asymmetric ion mobility spectrometry device | |
| CN102313776B (en) | Ion mobility spectrometry | |
| CN103163206A (en) | Composite ionization source difference type ion mobility spectrometry | |
| CN102478545A (en) | Planar differential ion mobility spectrometer | |
| CN104054156B (en) | Differential type mobility of ions spectrometer | |
| CN106601583A (en) | Space focusing conical high field asymmetric waveform transference tube | |
| CN103887141B (en) | A kind of ionic migration spectrometer | |
| US20160153937A1 (en) | Ion Mobility Separation Device | |
| CN103776893B (en) | A kind of dielectric barrier discharge ionization source ionic migration spectrometer | |
| CN108088891A (en) | A kind of ion mobility spectrometry and operating method for being disposed vertically VUV radio-frequency lamps | |
| CN111220678A (en) | Ion mobility spectrometer |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20180529 |