CN108089011A - A kind of new application of tachysynthesis detecting system in operation - Google Patents
A kind of new application of tachysynthesis detecting system in operation Download PDFInfo
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- CN108089011A CN108089011A CN201810018176.8A CN201810018176A CN108089011A CN 108089011 A CN108089011 A CN 108089011A CN 201810018176 A CN201810018176 A CN 201810018176A CN 108089011 A CN108089011 A CN 108089011A
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- tachysynthesis
- detecting system
- test paper
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- blood
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/50—Determining the risk of developing a disease
Abstract
A kind of tachysynthesis detecting system differentiates that thyroid cancer whether there is metastasic cervical lymph nodes as the new application in operation by detecting the content of thyroglobulin.Concrete operation step includes, a, and thyroid gland areas lymph node tissue is punctured；B prepares the eluent of puncturing tissue；C directly carries out thyroglobulin TG to the eluent of preparation by tachysynthesis detecting system and quantifies detection process；D, the TG testing results obtained according to tachysynthesis detecting system differentiate that regional lymph nodes whether there is metastasis of thyroid carcinoma.C is specifically, eluent is dripped into TG test paper, the detection line and nature controlling line on TG test paper are scanned by the detector of immune detection system again, and the processing unit by being set inside detector carries out parameter calculating processing, obtains the content of the thyroglobulin TG in tissue.It bedside can directly operate, have the characteristics that easy to operate, quick in art.
Description
Technical field
It is new in operation more particularly to a kind of tachysynthesis detecting system the present invention relates to technical field of medical equipment
Purposes.
Background technology
Thyroglobulin Tg is the macromolecular glycoprotein of thyroid follicular epithelial cells secretion, is normally present in normal thyroid group
In the human thyroid carcinoma and the lymph node of transfer knit, broken up, and the concentration in tissue fluid is far above the concentration in serum, therefore
In Follow up Patients with Differentiated Thyroid Cancer, if detecting high concentration Tg in tissue outside thyroid gland, highly vigilant of thyroid cancer is answered
The possibility of transfer.
FNA-Tg (FNA fine needle puncture Tg values) detection technique reported first in 1992 by Pacini etc., easy to operate,
Accurately, and the subjectivity of pathological diagnosis can be avoided to a certain extent, be widely used to clinic.The accurate assessment of lymph node is to face
The basis of bed decision-making, American Thyroid Association's (ATA) guide is using FNA-Tg as thyroid cancer preoperative and postoperative lymph node assessment
New technology is recommended, and new foundation is provided for the formulation of neck lymph dissection strategy.
FNA-Tg (FNA fine needle puncture Tg values) checks the characterization of molecules based on thyroid cancer, turns in differentiated thyroid carcinoma
It is a dark horse in the diagnosis of shifting, accessory products and auxiliary examination as aspiration biopsy do not increase patient trauma, but FNA-Tg
It is a kind of semiquantitative index, there is no current diagnosis reference value at present.Therefore, palpus integrated application aided diagnosis technique is kept away with making the best use of the advantages
It is short.FNA-Tg aids in FNAC that can thyroid papillary carcinoma diagnosing lymph node metastatsis be promoted about 13% in the researchs such as Al-Hilli,
Being used in combination helps to reduce false negative rate.The data of many units is also shown in the assessment of neck lateral areas lymph node at present
Ultrasound, FNAC, FNA-Tg use in conjunction can evade the weakness of single technology, improve the susceptibility and accuracy rate of diagnosis, can be
Integrated application during dissection decision-making.
But FNA-Tg detection process operate in itself or it is relative complex, it is necessary to select fine needle puncture (puncture needle for 21-
25G pins, connection 5ml syringes), it then takes out and punctures object smear, absolute ethyl alcohol is fixed, HE is dyed, all puncture lesions positions
It is clearly marked with corresponding sample, after one-to-one corresponding, pathology department is sent to do cytolgical examination.Then water lotion is made, send Tg horizontal
Detection, Tg detections are using Electrochemiluminescince.Diagnose whether cervical lymph node is transfer lymph using 100ng/ml as FNA-Tg
The cutoff value of knot, FNA-Tg>100ng/ml is metastatic, FNA-Tg<100ng/ml is benign.
FNA-Tg is measured draws 0.3ml0.9% physiological saline with 1ml syringes, and the eluent censorship of about 1ml is made.Elution
Liquid centrifuges 5min using 18 centrifuge 1000g of Beckman-Coulter Mi-crofuge, supernatant is taken, using immune electricity
Chemoluminescence method detects Tg contents.
In practice, in the case of needing to judge particularly to need to judge immediately in operation immediately, if as existing
Test method in technology is then needed measure object being centrifuged repeatedly, tested.Practical operation often turns from operating room by sample
To sensing chamber, sensing chamber carries out being centrifuged repeatedly the operations such as processing again, then detection structure is fed back to operation side.This processing mode
Not only the time is spent significantly, and it is complicated for operation, it is impossible to meet convenient demand immediately.
Judge that the golden standard whether thyroid cancer cervical lymph node shifts is cut into slices for early diagnosis, it is necessary to phase at present
The fine equipment of pathology technical professional, experienced Pathology Doctors ' and its costliness are closed, routine inspection takes 40 minutes left sides
It is right.
Therefore, in view of the shortcomings of the prior art, a kind of tachysynthesis detecting system is provided as the new application in operation, with reality
It is now quick, simple, accurately obtain by side object Tg contents situation judging whether thyroid cancer metastasic cervical lymph nodes
It is very necessary to overcome the shortage of prior art.
The content of the invention
A kind of tachysynthesis detecting system is provided in hand it is an object of the invention to avoid the deficiencies in the prior art part
New application in art can directly operate in art, have the characteristics of easy to operate, time-saving and efficiency.
The above-mentioned purpose of the present invention is realized by following technological means.
A kind of new application of tachysynthesis detecting system in operation is provided, by the TG for detecting thyroid gland areas lymph node
Level judges that regional lymph nodes whether there is metastasis of thyroid carcinoma.
Preferably, new application of the above-mentioned tachysynthesis detecting system in operation, concrete operation step include,
A punctures thyroid gland areas lymph node tissue；
B prepares the eluent of puncturing tissue；
C directly carries out the eluent of preparation by tachysynthesis detecting system thyroglobulin TG quantitatively at detection
Reason；
D, the TG testing results obtained according to tachysynthesis detecting system differentiate that regional lymph nodes whether there is thyroid cancer
Transfer.
Preferably, above-mentioned steps c is specifically that eluent is dripped to TG test paper, then the detector for passing through immune detection system
The detection line and nature controlling line on TG test paper are scanned, and the processing unit by being set inside detector carries out parameter calculating processing,
Obtain the content of the thyroglobulin TG in tissue.
Preferably, new application of the above-mentioned tachysynthesis detecting system in operation, processing unit automatic decision penetrating area
The TG content situations of lymph node.
Preferably, new application of the above-mentioned tachysynthesis detecting system in operation, step d are specifically by the TG in eluent
Value is compared with the TG detection basic values in blood simultaneously, when ratio is more than 1, then judges that there are thyroid cancer regional lymphatics to carry down
It moves.
Preferably, new application of the above-mentioned tachysynthesis detecting system in operation, basic value is specifically in blood,
The processing sample of blood or blood is dripped into detection TG test paper, then is scanned by the detector of immune detection system on TG test paper
Detection line and nature controlling line, and the processing unit by setting inside detector is obtained in the processing sample of blood or blood
TG contents.
Preferably, the TG detection basic values in blood are that the blood of collection in worksite is detected to obtain either to opponent
The blood that art starts to gather in advance at that time is detected to obtain.
Preferably, new application of the above-mentioned tachysynthesis detecting system in operation, eluent drip to TG test paper, and TG test paper is in
Existing different coloured panel, detector are scanned according to the band shade reading presented on TG test paper, and to shade
Band assignment.
Preferably, for above-mentioned TG test paper for testing and showing thyroglobulin Tg contents, the TG test paper is immune glue
Body gold test paper；Display scale on test paper is denoted as content.
Preferably, new application of the above-mentioned tachysynthesis detecting system in operation, step a specifically using fine needle puncture, are worn
Pricker point generates negative pressure into pumpback syringe behind target site inside, and multiple spot puff count is not less than 3 times repeatedly, the then withdraw of the needle
Sampling；
Step b is entered back into, puncture needle and syringe 0.9% sodium chloride injections of 1ml are rinsed, 1ml elutions are made
Liquid.
A kind of tachysynthesis detecting system of the present invention is as the new application in operation, by detecting thyroglobulin
Content come differentiate thyroid cancer whether there is metastasic cervical lymph nodes.It operating room especially can be that by performing the operation in art
Room bedside directly operates, and avoid needs puncturing tissue being sent to fiber crops of the laboratory using centrifugation detection process in the prior art
It is tired, have the characteristics that easy to operate, quick.
Description of the drawings
Using attached drawing, the present invention is further illustrated, but the content in attached drawing does not form any limit to the present invention
System.
Fig. 1 is the three dimensional structure diagram of thyroglobulin Tg.
Fig. 2 is the schematic diagram of the quantitative analysis detecting system the present invention is based on Tg test paper.
Specific embodiment
The invention will be further described with the following Examples.
Embodiment 1.
A kind of tachysynthesis detecting system is reflected as the new application in operation by detecting the content of thyroglobulin
Other thyroid cancer whether there is metastasic cervical lymph nodes.
The three-dimensional structure of thyroglobulin Tg is as shown in Figure 1, thyroglobulin is a kind of iodine in parathyroid tissue
Change glycoprotein, for homodimer, molecular mass about 660kDa.The subunit of human thyroglobulin is by 2767 amino acid residues
Composition.When Tg vivo biodistribution half-life period is 65.2 small.Sentenced by thyroglobulin Tg contents in detection zone lymph node tissue
Surely with the presence or absence of thyroid cancer metastasic cervical lymph nodes, foundation can be provided for dissection decision-making.
Tachysynthesis detecting system employed in the present embodiment, is made of, as shown in Figure 2 Tg test paper and detector.
Tg test paper is tested and shows the content of tissue thyroglobulin Tg, when detecting that FNA-Tg is more than rated value
There is positive detection line；
Detector, scans detection line and nature controlling line on Tg test paper, and the processing unit by setting inside detector into
Row parameter calculating processing obtains the content of the thyroglobulin Tg in tissue.
The tachysynthesis detecting system, is additionally provided with display screen, and the processing unit connection of display screen and detector will be handled
The parameter that unit calculates is shown.
According to the content for detecting the thyroglobulin Tg in obtained regional lymphatics nodal tissue, it can be used as and judge area
Domain lymph node whether there is the foundation of thyroid cancer metastasic cervical lymph nodes, provided for clinical dissection instruct according to
According to.It is applied widely available for the detection of any occasion with easy to operate simple, visual result.
The tachysynthesis detecting system includes as the new application in operation, concrete operation step,
A punctures thyroid gland areas lymph node tissue；
B prepares the eluent of puncturing tissue；
C directly carries out the eluent of preparation by tachysynthesis detecting system thyroglobulin TG quantitatively at detection
Reason；
D, the TG testing results obtained according to tachysynthesis detecting system differentiate that regional lymph nodes whether there is thyroid cancer
Transfer.
Wherein, step a is specifically using fine needle puncture, and the generation of pumpback syringe is negative after needle tip enters target site inside
Pressure, not less than 3 times, the then withdraw of the needle samples multiple spot puff count repeatedly；Step b is entered back into, by puncture needle and syringe 1ml
0.9% sodium chloride injection rinses, and eluent is made.
Step c is specifically that eluent is dripped to TG test paper, then is scanned by the detector of immune detection system on TG test paper
Detection line and nature controlling line, and the processing unit by setting inside detector carries out parameter calculating processing, obtains in tissue
The content of thyroglobulin TG.Wherein, eluent drips to TG test paper, and different coloured panels is presented in TG test paper, and detector is swept
It retouches according to the band shade reading presented on TG test paper, and to the band assignment of shade.It is operated by Tg test paper non-
Often simple, testing result directly shows there is intuitive and convenient on Tg test paper.
Specifically, Tg test paper is arranged to immune colloid gold test paper, for showing tissue thyroid gland ball in FNA-Tg detections
The content of albumen Tg.
Thyroglobulin (Tg) detection reagent uses solid-phase immunity Chromatographic techniques, former using double antibody sandwich method
Reason, gold-labelled monoclonal antibody or the coated antibody of microballoon and the Tg protein bindings to be checked in sample, form immune complex, and with sample
Chromatography, with pre-coated capture antibody further combined with detection line is formed, within the specific limits, detects line color to test section
The depth and sample in thyroglobulin (Tg) proportional.After the completion of reaction, by detector to detection line and
Nature controlling line is scanned analysis, and is calculated according to the preset parameter of instrument internal, so as to quantitatively detect thyroid gland in blood
The content of globulin (Tg).
The Tg test paper directly detects tissue, directly displays thyroglobulin Tg contents in tissue, easy to operate
Simply.It is applied widely available for the detection of any occasion.Tg test paper through this embodiment, overcomes in the prior art
Detecting thyroglobulin Tg contents in tissue needs the complicated processes of continuous centrifugal treating, has easy to operate simple spy
Point.
This tachysynthesis detecting system is differentiated as the new application in operation by detecting the content of thyroglobulin
Thyroid cancer whether there is metastasic cervical lymph nodes.It can directly be operated in art, avoiding needs to puncture in the prior art
Tissue is sent to the trouble of laboratory centrifugation detection process, has the characteristics that easy to operate, quick.
Embodiment 2.
A kind of tachysynthesis detecting system is as the new application in operation, and other feature is same as Example 1, difference
It is：Step d is specifically by the TG values in eluent compared with the TG detection basic values in blood simultaneously, when ratio is more than 1, then
Judge that there are thyroid cancer regional lymph node metastasis.Blood refers to same time, the blood of same target simultaneously.
Basic value is specifically in blood, and the processing sample of blood or blood is dripped to detection TG test paper, then is led to
Cross the detection line and nature controlling line on the detector scanning TG test paper of immune detection system, and the processing by being set inside detector
Unit obtains the TG contents in the processing sample of blood or blood.
TG detection basic values in blood can be that the blood of collection in worksite is detected to obtain either to opening operation
The blood for beginning to gather in advance at that time is detected to obtain.
TG values in test serum are compared the present embodiment with the basic value in blood simultaneously, provide another
Judgment mode has the characteristics that easy to detect, result is accurate.
Finally it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention rather than the present invention is protected
The limitation of scope, although being explained in detail with reference to preferred embodiment to the present invention, those of ordinary skill in the art should manage
Solution, technical scheme can be modified or replaced equivalently, without departing from technical solution of the present invention essence and
Scope.
Claims (10)
1. a kind of new application of tachysynthesis detecting system in operation, it is characterised in that：By detecting thyroid gland areas lymph
The TG of knot is horizontal, judges that regional lymph nodes whether there is metastasis of thyroid carcinoma.
2. new application of the tachysynthesis detecting system according to claim 1 in operation, it is characterised in that：
Concrete operation step includes,
A punctures thyroid gland areas lymph node tissue；
B prepares the eluent of puncturing tissue；
C directly carries out thyroglobulin TG to the eluent of preparation by tachysynthesis detecting system and quantifies detection process；
D, the TG testing results obtained according to tachysynthesis detecting system differentiate that regional lymph nodes whether there is metastasis of thyroid carcinoma.
3. new application of the tachysynthesis detecting system according to claim 2 in operation, it is characterised in that：
The step c is specifically that eluent is dripped to TG test paper, then is scanned by the detector of immune detection system on TG test paper
Detection line and nature controlling line, and the processing unit by setting inside detector carries out parameter calculating processing, obtains in tissue
The content of thyroglobulin TG.
4. new application of the tachysynthesis detecting system according to claim 3 in operation, it is characterised in that：Processing unit
The TG content situations of automatic decision penetrating area lymph node.
5. new application of the tachysynthesis detecting system according to claim 4 in operation, it is characterised in that：Step d has
Body is by the TG values in eluent compared with the TG detection basic values in blood simultaneously, and when ratio is more than 1, then there are first shapes for judgement
Gland cancer regional lymph node metastasis.
6. new application of the tachysynthesis detecting system according to claim 5 in operation, it is characterised in that：Base in blood
Plinth value is specifically that the processing sample of blood or blood is dripped to detection TG test paper, then passes through immune detection system
Detection line and nature controlling line on detector scanning TG test paper, and the processing unit by setting inside detector obtain blood or
TG contents in the processing sample of blood.
7. new application of the tachysynthesis detecting system according to claim 6 in operation, it is characterised in that：In blood
TG detections basic value is that the blood of collection in worksite is detected to obtain either to start the blood gathered in advance at that time to operation
It is detected to obtain.
8. new application of the tachysynthesis detecting system according to claim 7 in operation, it is characterised in that：Elute drop
To TG test paper, different coloured panels is presented in TG test paper, and detector scanning is read according to the band shade presented on TG test paper
Number, and to the band assignment of shade.
9. new application of the tachysynthesis detecting system according to claim 8 in operation, it is characterised in that：The TG examinations
For paper for testing and showing thyroglobulin Tg contents, the TG test paper is immune colloid gold test paper；Display on test paper is carved
Scale is shown as content.
10. new application of the tachysynthesis detecting system according to claim 9 in operation, it is characterised in that：
For step a specifically using fine needle puncture, pumpback syringe generates negative pressure after needle tip enters target site inside, repeatedly more
Not less than 3 times, the then withdraw of the needle samples point puff count；
Step b is entered back into, puncture needle and syringe 1ml0.9% sodium chloride injections are rinsed, 1ml eluents are made.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810018176.8A CN108089011A (en) | 2018-01-09 | 2018-01-09 | A kind of new application of tachysynthesis detecting system in operation |
| PCT/CN2018/095063 WO2019136947A1 (en) | 2018-01-09 | 2018-07-10 | Novel use of rapid immunoassay system in surgery |
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| CN201810018176.8A CN108089011A (en) | 2018-01-09 | 2018-01-09 | A kind of new application of tachysynthesis detecting system in operation |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108445237A (en) * | 2018-06-20 | 2018-08-24 | 广州市康润生物科技有限公司 | A kind of new application of PTH tachysynthesises detecting system |
| WO2019136947A1 (en) * | 2018-01-09 | 2019-07-18 | 广州市康润生物科技有限公司 | Novel use of rapid immunoassay system in surgery |
| CN110275014A (en) * | 2019-07-23 | 2019-09-24 | 江苏省原子医学研究所 | Quickly identify the method for thyroid papillary carcinoma Cervical Lymph Node Metastasis in a kind of art |
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| CN108089011A (en) * | 2018-01-09 | 2018-05-29 | 广州市康润生物科技有限公司 | A kind of new application of tachysynthesis detecting system in operation |
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2018
- 2018-01-09 CN CN201810018176.8A patent/CN108089011A/en active Pending
- 2018-07-10 WO PCT/CN2018/095063 patent/WO2019136947A1/en active Application Filing
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| CN106932573A (en) * | 2017-04-28 | 2017-07-07 | 天津医科大学总医院 | Detect immunity colloidal gold test paper strip of thyroglobulin and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2019136947A1 (en) * | 2018-01-09 | 2019-07-18 | 广州市康润生物科技有限公司 | Novel use of rapid immunoassay system in surgery |
| CN108445237A (en) * | 2018-06-20 | 2018-08-24 | 广州市康润生物科技有限公司 | A kind of new application of PTH tachysynthesises detecting system |
| CN110275014A (en) * | 2019-07-23 | 2019-09-24 | 江苏省原子医学研究所 | Quickly identify the method for thyroid papillary carcinoma Cervical Lymph Node Metastasis in a kind of art |
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| WO2019136947A1 (en) | 2019-07-18 |
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