CN108070527A - Gene sequencer forces cleaning method and system - Google Patents
Gene sequencer forces cleaning method and system Download PDFInfo
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- CN108070527A CN108070527A CN201610996171.3A CN201610996171A CN108070527A CN 108070527 A CN108070527 A CN 108070527A CN 201610996171 A CN201610996171 A CN 201610996171A CN 108070527 A CN108070527 A CN 108070527A
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
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Abstract
The present invention relates to a kind of gene sequencers to force cleaning method and system, and the described method includes interface Eject steps, show that one cleans startup interface automatically at the end of gene sequencing flow；Timed process is responded, timing is carried out to state of the automatic cleaning startup interface without operation response；And cleaning starting step, perform automatic cleaning function after the timing is more than the default time limit.The gene sequencer of the present invention forces cleaning method and system to solve the problems, such as that user's human error is forgotten to clean liquid channel system.
Description
Technical field
The present invention relates to gene sequencing field, it is more particularly related to which a kind of gene sequencer forces cleaning side
Method and system.
Background technology
Gene sequencer generally includes sequencing board and control system, and sequencing board includes control reagent component input and output
Liquid channel system, the liquid channel system is usually using nine holes pump as power-equipment.After completing gene sequencing under normal circumstances,
Need to clean liquid channel system, with keep liquid channel system cleaning and it is unobstructed.Since the gene sequencing consuming time is long, because
After this sequencing is completed, whether user may not be same user at the scene or before and after testing, to having carried out clearly
It washes or needs to clean and do not know about, may result in and forget to clean, and then cause reaction reagent in fluid path pipeline and nine holes pump residual
Liquid solidification and crystallization, and then block fluid path systematic influence gene sequencer normal use.
The content of the invention
It is an object of the invention to provide a kind of gene sequencers to force cleaning method and system, it is intended to solve the prior art
Liquid channel system easily forgets the problem of cleaning.
A kind of gene sequencer forces cleaning method, including interface Eject step, is shown at the end of gene sequencing flow
Show an automatic cleaning startup interface；Timed process is responded, state of the automatic cleaning startup interface without operation response is carried out
Timing；And cleaning starting step, perform automatic cleaning function after the timing is more than the default time limit.
As an improvement, further comprising environment induction step after the response timed process, held for cleaning starting step
Whether sensing gene sequencer nearby has user before row, if it is determined that gene sequencer nearby has user then to re-execute response
Timed process, if it is determined that gene sequencer does not nearby have user then to perform cleaning starting step.
As an improvement, the environment induction step is attached to gene sequencer using one or more infrared human body sensors
Near user is sensed.
As an improvement, the automatic cleaning startup interface, which includes multiple parameters, sets field, for selecting to clean work(automatically
Multiple environmental parameters of needs can be performed.
As an improvement, further comprising parameter call step before performing the cleaning starting step, cleaned for reading
Multiple environmental parameters that last cleaning uses in daily record.
As an improvement, the gene sequencer includes liquid channel system, the automatic cleaning function is for gene sequencing
The liquid channel system of instrument carries out.
As an improvement, the liquid channel system is pumped including nine holes, the automatic cleaning function is nine holes for liquid channel system
Pump carries out.
A kind of gene sequencer forces cleaning system, including interface pop-up module, for terminating in gene sequencing flow
When display one automatically cleaning startup interface；Timing module is responded, for what is responded to the automatic cleaning startup interface without operation
State carries out timing；And cleaning starting module, for performing automatic cleaning function after the timing is more than the default time limit.
As an improvement, the gene sequencer forces cleaning system to further comprise environment induction module, in timing
Nearby whether there is user more than gene sequencer is sensed after the default time limit, if it is determined that gene sequencer nearby has user then to respond
The clocking capability that timing module re-executes performs certainly if it is determined that gene sequencer does not have nearby user then to clean starting module
Dynamic cleaning function.
As an improvement, the environment induction module is attached to gene sequencer using one or more infrared human body sensors
Near user is sensed.
As an improvement, the automatic cleaning startup interface, which includes multiple parameters, sets field, for selecting to clean work(automatically
Multiple environmental parameters of needs can be performed.
As an improvement, the gene sequencer forces cleaning system to further comprise parameter calling module, it is clear for reading
Wash multiple environmental parameters that last cleaning uses in daily record.
As an improvement, the gene sequencer includes liquid channel system, the automatic cleaning function is for gene sequencer
Liquid channel system carry out.
As an improvement, the liquid channel system is pumped including nine holes, the automatic cleaning function is nine holes for liquid channel system
Pump carries out.
Compared with the prior art, gene sequencer of the invention force cleaning method and system at the end of gene sequencing from
Dynamic pop-up display one cleans startup interface automatically, when state of the automatic cleaning startup interface without operation response is more than default
Automatic cleaning function is performed after limit, solves the problems, such as that user's human error is forgotten to clean liquid channel system.Further, performing
Before automatic cleaning function, gene sequencer of the invention forces cleaning method and system to further determine whether user existing
, when the situation of user not at the scene just cleans liquid channel system automatically, the accurately and timely property cleaned automatically is further ensured, is kept away
Exempt from the multiple gene sequencing work that interference is carried out continuously.
Description of the drawings
Fig. 1 is the flow diagram that first embodiment of the invention gene sequencer forces cleaning method.
Fig. 2 is the flow diagram that second embodiment of the invention gene sequencer forces cleaning method.
Fig. 3 is the running environment schematic diagram that first embodiment of the invention gene sequencer forces cleaning system.
Specific embodiment
In order to make the purpose , technical scheme and advantage of the present invention be clearer, below in conjunction with drawings and the embodiments,
The present invention will be described in further detail.
Fig. 1 be first embodiment of the invention gene sequencer force cleaning method flow diagram, the gene sequencing
Instrument forces cleaning method to include step S11- steps S13.
Interface Eject step S11, the cleaning startup interface automatically of display one at the end of gene sequencing flow.In the present embodiment,
Different genes sequencing flow is set in advance, user selects corresponding gene sequencing flow before sequencing is started, described
Gene sequencing flow includes sequencing and terminates flow.It is performed when the sequencing terminates flow, system is controlled in gene sequencer
Startup interface is cleaned in display one automatically in the form of pop-up in the display device of system.In the present embodiment, the automatic cleaning starts
Interface includes multiple parameters and sets field, for automatic cleaning function to be selected to be performed multiple environmental parameters of needs.It is preferably real
It applies in example, the environmental parameter includes cleaning object, cleaning fluid volume, cleaning temperature etc..
Timed process S12 is responded, timing is carried out to state of the automatic cleaning startup interface without operation response.This implementation
In example, the automatic cleaning startup interface includes a confirming button and cancel button, starts to hold after user clicks confirming button
Row cleaning function.Cleaning function is not performed when user clicks cancel button.In the present embodiment, system starts boundary to cleaning automatically
It is not responded to after the pop-up of face or unattended situation carries out timing, timing is more than execution step S13 after the default time limit.
Starting step S13 is cleaned, the timing is more than to perform automatic cleaning function after presetting the time limit.In the present embodiment, institute
Stating gene sequencer includes liquid channel system, and the automatic cleaning function is the liquid channel system for being directed to gene sequencer, especially
The nine holes pump of liquid channel system carries out.Nine holes pump the core equipment as liquid channel system, and precise structure is led if as forgetting to clean
Reaction reagent raffinate solidification and crystallization in the pump of nine holes is caused, liquid channel system can be caused, which to block, influences gene sequencer normal use.This reality
It applies in example, automatic cleaning function is performed to gene sequencer using default environmental parameter.
In alternate embodiment, after the default time limit, before starting to perform automatic cleaning function, a ginseng can be further performed
Number invocation step cleans multiple environmental parameters that last cleaning uses in daily record, using these parameters to gene for reading
Sequenator performs automatic cleaning function.
The gene sequencer of the present invention forces cleaning method, and cleaning starts pop-up display one automatically at the end of gene sequencing
Interface performs automatic cleaning function after being more than to preset the time limit when state of the interface without operation response, reduces human error
The problem of forgetting to clean liquid channel system.
Fig. 2 is the flow diagram that second embodiment of the invention gene sequencer forces cleaning method.The gene sequencing
Instrument forces cleaning method to include step S11- steps S14.
Interface Eject step S11, the cleaning startup interface automatically of display one at the end of gene sequencing flow.In the present embodiment,
Different genes sequencing flow is set in advance, user selects corresponding gene sequencing flow before sequencing is started, described
Gene sequencing flow includes sequencing and terminates flow.It is performed when the sequencing terminates flow, in gene sequencing control system
Display device in the form of pop-up display one automatically cleaning startup interface.In the present embodiment, the automatic cleaning starts boundary
Face includes multiple parameters and sets field, for automatic cleaning function to be selected to be performed multiple environmental parameters of needs.Preferably implement
In example, the environmental parameter includes cleaning object, cleaning fluid volume, cleaning temperature etc..
Timed process S12 is responded, timing is carried out to state of the automatic cleaning startup interface without operation response.This implementation
In example, the automatic cleaning startup interface includes a confirming button and cancel button, starts to hold after user clicks confirming button
Row cleaning function.Cleaning function is not performed when user clicks cancel button.In the present embodiment, system starts boundary to cleaning automatically
It is not responded to after the pop-up of face or unattended situation carries out timing, timing is more than execution step S14 after the default time limit.
Environment induction step S14, whether sensing gene sequencer nearby has user, if it is determined that gene sequencer nearby has
User then re-executes response timed process S12, user is waited to being operated to cleaning startup interface automatically, if it is determined that base
Because sequenator does not have nearby user then to perform cleaning starting step S13.In the present embodiment, the environment induction step uses one
Or multiple infrared human body sensors sense the user near gene sequencer.In preferred embodiment, it is one or
The top in house where multiple infrared human body sensors may be mounted at sequenator.
Clean starting step S13, the timing be more than the default time limit and nobody be located near sequenator, perform and clean automatically
Function.In the present embodiment, the gene sequencer includes liquid channel system, and the automatic cleaning function is for gene sequencer
Liquid channel system carry out.In preferred embodiment, the liquid channel system is pumped including nine holes, and the automatic cleaning function is for nine
Hole pump carries out.Nine holes pump the core equipment as liquid channel system, and precise structure causes in the pump of nine holes instead if as forgetting to clean
Reagent raffinate solidification and crystallization is answered, liquid channel system can be caused, which to block, influences gene sequencer normal use.In the present embodiment, using pre-
If environmental parameter to gene sequencer perform automatic cleaning function.
In alternate embodiment, more than the default time limit and nobody be located near sequenator, start perform automatic cleaning function it
Before, a parameter call step can be further performed, multiple environmental parameters that last cleaning uses in daily record are cleaned for reading,
Automatic cleaning function is performed to gene sequencer using these parameters.
The gene sequencer of the present embodiment forces cleaning method, and pop-up display one automatically open by cleaning at the end of gene sequencing
Arena face further determines whether user at the scene after the state without operation response is more than the default time limit when the interface, when
The situation of user not at the scene just cleans liquid channel system automatically, has not only ensured the cleaning of liquid channel system and unobstructed, also further
It ensure that the accurately and timely property cleaned automatically, avoid the normal operation selection of interference user, it is multiple to prevent that interruption is carried out continuously
Gene sequencing works.
In alternate embodiment, can also timing be carried out to the situation of user not at the scene, when the situation of user not at the scene surpasses
Automatic cleaning function is just performed after crossing preset time.
Fig. 3 is the running environment schematic diagram that first embodiment of the invention gene sequencer forces cleaning system.The present invention carries
It can be the embedded integration chip for having specific function that the gene sequencer of confession, which forces the module of cleaning system 100 and its inside,
Or the software code performed in write-in memory 500 by processor 400.
The gene sequencer forces cleaning system 100 to include interface pop-up module 110, response timing module 120, cleaning
Starting module 130 and environment induction module 140.
The interface pop-up module 110 is used for the display one at the end of gene sequencing flow and cleans startup interface automatically.This
In embodiment, different genes sequencing flow is set in advance, user selects corresponding gene sequencing before sequencing is started
Flow, the gene sequencing flow include sequencing and terminate flow.It is performed when the sequencing terminates flow, in gene sequencing
Startup interface is cleaned in display one automatically in the form of pop-up in the display device of instrument control system.It is described automatic in the present embodiment
Cleaning startup interface includes multiple parameters setting field, for automatic cleaning function to be selected to be performed multiple environment ginseng of needs
Number.In preferred embodiment, the environmental parameter includes cleaning object, cleaning fluid volume, cleaning temperature etc..
The response timing module 120 is based on carrying out state of the automatic cleaning startup interface without operation response
When.In the present embodiment, the automatic cleaning startup interface includes a confirming button and cancel button, when user clicks confirming button
After start perform cleaning function.Cleaning function is not performed when user clicks cancel button.In the present embodiment, system is to automatic clear
It is not responded to after washing startup interface pop-up or unattended situation carries out timing.
Whether the environment induction module 140 has user for sensing near gene sequencer.In the present embodiment, the ring
Border sensing step senses the user near gene sequencer using one or more infrared human body sensors.It is preferably real
It applies in example, the top in house where one or more of infrared human body sensors may be mounted at sequenator.
The cleaning starting module 130 be used for the timing be more than the default time limit and nobody be located near sequenator, hold
Row automatic cleaning function or for performing automatic cleaning function after the timing is more than the default time limit.In the present embodiment, base
Because sequenator 200 includes liquid channel system, the liquid channel system includes liquid-transfering needle 210, reagent platform 220, fluid path pipeline 230, anti-
Answer cell 240, nine holes pump 250.The automatic cleaning function is carried out primarily directed to the liquid channel system of gene sequencer.It is preferably real
It applies in example, the automatic cleaning function is carried out for nine holes pump 250.Nine holes pump 250 core equipment as liquid channel system,
Precise structure causes reaction reagent raffinate solidification and crystallization in nine holes pump 250 if as forgetting to clean, liquid channel system can be caused to block up
Plug influences gene sequencer normal use.In the present embodiment, gene sequencer is performed using default environmental parameter automatic clear
Wash function.
In alternate embodiment, can further comprise a parameter calling module, for be more than the default time limit and nobody be located at survey
Near sequence instrument, before starting to perform automatic cleaning function, multiple environmental parameters that last cleaning uses in cleaning daily record are read,
Automatic cleaning function is performed to gene sequencer using these parameters.
The gene sequencer of the present embodiment forces cleaning method, and pop-up display one automatically open by cleaning at the end of gene sequencing
Arena face further determines whether user at the scene after the state without operation response is more than the default time limit when the interface, when
The situation of user not at the scene just cleans liquid channel system automatically, has not only ensured the cleaning of liquid channel system and unobstructed, also further
It ensure that the accurately and timely property cleaned automatically, avoid the normal operation selection of interference user, it is multiple to prevent that interruption is carried out continuously
Gene sequencing works.
In alternate embodiment, the environment induction module 140 can also be used for after the timing is more than the default time limit directly
Perform automatic cleaning function.
Compared with the prior art, gene sequencer of the invention force cleaning method and system at the end of gene sequencing from
Dynamic pop-up display one cleans startup interface automatically, and execution is automatic after state of the interface without operation response is more than the default time limit
Cleaning function solves the problems, such as that user's human error is forgotten to clean liquid channel system.Further, automatic cleaning function is being performed
Before, gene sequencer of the invention forces cleaning method and system to further determine whether user at the scene, when user not
Situation at the scene just cleans liquid channel system automatically, further ensures the accurately and timely property cleaned automatically, avoids interference continuous
The multiple gene sequencing work carried out.
In alternate embodiment, response timing module 120 can also to user, situation at the scene does not carry out timing, when user not
Situation at the scene just performs automatic cleaning function more than cleaning starting module 130 after preset time.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all essences in the present invention
All any modification, equivalent and improvement made within refreshing and principle etc., should all be included in the protection scope of the present invention.
Claims (14)
1. a kind of gene sequencer forces cleaning method, including：
Interface Eject step shows that one cleans startup interface automatically at the end of gene sequencing flow；
Timed process is responded, timing is carried out to state of the automatic cleaning startup interface without operation response；And
Starting step is cleaned, automatic cleaning function is performed after the timing is more than the default time limit.
2. gene sequencer according to claim 1 forces cleaning method, which is characterized in that after the response timed process
Further comprise environment induction step, for cleaning whether sensing gene sequencer before starting step performs nearby has user,
If it is determined that gene sequencer nearby has user then to re-execute response timed process, if it is determined that gene sequencer does not have nearby
User then performs cleaning starting step.
3. gene sequencer according to claim 2 forces cleaning method, which is characterized in that the environment induction step is adopted
The user near gene sequencer is sensed with one or more infrared human body sensors.
4. gene sequencer according to claim 1 forces cleaning method, which is characterized in that the automatic cleaning starts boundary
Face includes multiple parameters and sets field, for automatic cleaning function to be selected to be performed multiple environmental parameters of needs.
5. gene sequencer according to claim 4 forces cleaning method, which is characterized in that performs the cleaning and starts step
Further comprise parameter call step before rapid, multiple environmental parameters that last cleaning uses in daily record are cleaned for reading.
6. gene sequencer according to claim 1 forces cleaning method, which is characterized in that the gene sequencer includes
Liquid channel system, the automatic cleaning function is the liquid channel system progress for being directed to gene sequencer.
7. gene sequencer according to claim 6 forces cleaning method, which is characterized in that the liquid channel system includes nine
Hole pumps, and the automatic cleaning function is the nine holes pump progress for liquid channel system.
8. a kind of gene sequencer forces cleaning system, including：
Interface pop-up module, for the automatic cleaning startup interface of display one at the end of gene sequencing flow；
Timing module is responded, for carrying out timing to state of the automatic cleaning startup interface without operation response；And
Starting module is cleaned, for performing automatic cleaning function after the timing is more than the default time limit.
9. gene sequencer according to claim 8 forces cleaning system, which is characterized in that further comprises environment induction
Module, for sensing near gene sequencer whether have user after timing is more than the default time limit, if it is determined that gene sequencer
Nearby there is user then to respond the clocking capability that timing module re-executes, if it is determined that gene sequencer is then clear without user nearby
It washes starting module and performs automatic cleaning function.
10. gene sequencer according to claim 8 forces cleaning system, which is characterized in that the environment induction module
The user near gene sequencer is sensed using one or more infrared human body sensors.
11. gene sequencer according to claim 8 forces cleaning system, which is characterized in that the automatic cleaning starts
Interface includes multiple parameters and sets field, for automatic cleaning function to be selected to be performed multiple environmental parameters of needs.
12. gene sequencer according to claim 11 forces cleaning system, which is characterized in that further comprises parameter tune
With module, multiple environmental parameters that last cleaning uses in daily record are cleaned for reading.
13. gene sequencer according to claim 8 forces cleaning system, which is characterized in that the gene sequencer bag
Liquid channel system is included, the automatic cleaning function is the liquid channel system progress for gene sequencer.
14. gene sequencer according to claim 13 forces cleaning system, which is characterized in that the liquid channel system includes
Nine holes pump, and the automatic cleaning function is the nine holes pump progress for liquid channel system.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610996171.3A CN108070527A (en) | 2016-11-11 | 2016-11-11 | Gene sequencer forces cleaning method and system |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610996171.3A CN108070527A (en) | 2016-11-11 | 2016-11-11 | Gene sequencer forces cleaning method and system |
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| CN201610996171.3A Pending CN108070527A (en) | 2016-11-11 | 2016-11-11 | Gene sequencer forces cleaning method and system |
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