CN108067481A - Gene sequencer cleaning method and system - Google Patents

Gene sequencer cleaning method and system Download PDF

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Publication number
CN108067481A
CN108067481A CN201611038814.XA CN201611038814A CN108067481A CN 108067481 A CN108067481 A CN 108067481A CN 201611038814 A CN201611038814 A CN 201611038814A CN 108067481 A CN108067481 A CN 108067481A
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China
Prior art keywords
gene
cleaning
automatic cleaning
sequencer
gene sequencer
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CN201611038814.XA
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Chinese (zh)
Inventor
盛司潼
费荣毅
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Guangzhou Kangxinrui Gene Health Technology Co Ltd
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Guangzhou Kangxinrui Gene Health Technology Co Ltd
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Priority to CN201611038814.XA priority Critical patent/CN108067481A/en
Publication of CN108067481A publication Critical patent/CN108067481A/en
Pending legal-status Critical Current

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    • BPERFORMING OPERATIONS; TRANSPORTING
    • B08CLEANING
    • B08BCLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
    • B08B9/00Cleaning hollow articles by methods or apparatus specially adapted thereto 
    • B08B9/02Cleaning pipes or tubes or systems of pipes or tubes
    • B08B9/027Cleaning the internal surfaces; Removal of blockages

Abstract

The present invention relates to a kind of gene sequencer cleaning method, including establishing monitoring queue according to the sequencing of multiple gene sequencing tasks;At the end of previous gene sequencing task, judge whether the interval time of the latter gene sequencing task and previous gene sequencing task exceeds threshold value;And show that one chooses whether to perform the automatic cleaning startup interface of automatic cleaning function for user if the interval time is beyond threshold value, otherwise wait for the latter gene sequencing task start.Present invention additionally comprises a kind of gene sequencer cleaning system, gene sequencer cleaning method of the invention and system can solve the problems, such as that prior art liquid channel system easily forgets cleaning.

Description

Gene sequencer cleaning method and system
Technical field
The present invention relates to gene sequencing field, it is more particularly related to a kind of gene sequencer cleaning method and System.
Background technology
Gene sequencer generally includes sequencing board and control system, and sequencing board includes control reagent component input and output Liquid channel system, the liquid channel system is usually using nine holes pump as power-equipment.After completing gene sequencing under normal circumstances, Need to clean liquid channel system, with keep liquid channel system cleaning and it is unobstructed.Since the gene sequencing consuming time is long, because This sequencing complete after, user may at the scene either test before and after not be same user, to equipment subsequently whether someone It is continuing with also not knowing, causes correctly decide whether to clean liquid channel system, in some instances it may even be possible to it can forget to clean, into And cause reaction reagent raffinate solidification and crystallization in fluid path pipeline and nine holes pump, and then block fluid path systematic influence gene sequencer just Often use.
The content of the invention
It is an object of the invention to provide a kind of gene sequencer cleaning method and systems, it is intended to solve prior art fluid path System easily forgets the problem of cleaning.
A kind of gene sequencer cleaning method includes:
Queue establishment step establishes monitoring queue according to the sequencing of multiple gene sequencing tasks;
Judgment step is spaced, at the end of previous gene sequencing task, judges the latter gene sequencing task and previous base Because whether the interval time of sequencing task exceeds threshold value;And
Interface Eject step shows that one chooses whether to perform automatic cleaning work(for user if the interval time is beyond threshold value The automatic cleaning startup interface of energy, otherwise waits for the latter gene sequencing task start.
As an improvement, after the gene sequencer cleaning method determines whether all gene sequencing tasks, display The automatic cleaning startup interface.
As an improvement, the gene sequencer cleaning method further comprises responding timed process, to the automatic cleaning State of the startup interface without operation response carries out timing, and automatic cleaning function is performed after the timing is more than the default time limit.
As an improvement, the gene sequencer cleaning method further comprises responding timed process, to the automatic cleaning State of the startup interface without operation response carries out timing, further comprises environment induction step after the response timed process, uses Nearby whether there is user in sensing gene sequencer, if it is determined that gene sequencer nearby has user, then re-execute response meter When step, be more than the default time limit if the timing and judge that gene sequencer performs if nearby not having user and clean work(automatically Energy.
As an improvement, the environment induction step is attached to gene sequencer using one or more infrared human body sensors Near user is sensed.
As an improvement, further comprising parameter call step before performing the automatic cleaning function, cleaned for reading Multiple environmental parameters that last cleaning uses in daily record.
As an improvement, the gene sequencer is pumped including nine holes, the automatic cleaning function is carried out for nine holes pump.
A kind of gene sequencer forces cleaning system to include:
Module is established in queue, for establishing monitoring queue according to the sequencing of multiple gene sequencing tasks;
Judgment module is spaced, at the end of previous gene sequencing task, judging the latter gene sequencing task and previous Whether the interval time of a gene sequencing task exceeds threshold value;And
Interface pop-up module, for showing that one chooses whether to perform cleaning work(automatically for user beyond threshold value in the interval time The automatic cleaning startup interface of energy, otherwise waits for the latter gene sequencing task start.
As an improvement, after all gene sequencing tasks, the interface pop-up module further shows described automatic Clean startup interface.
As an improvement, the gene sequencer forces cleaning system to further comprise responding timing module, to described automatic It cleans state of the startup interface without operation response and carries out timing, automatic cleaning work(is performed after the timing is more than the default time limit Energy.
As an improvement, the gene sequencer forces cleaning system to further comprise responding timing module and environment induction mould Block, the response timing module are used to carry out timing, the ring to state of the automatic cleaning startup interface without operation response Border sensing step if it is determined that gene sequencer nearby has user, then rings for sensing whether gene sequencer nearby has user Timing module reclocking is answered, be more than the default time limit if the timing and judges that gene sequencer performs if nearby not having user Automatic cleaning function.
As an improvement, the one or more infrared human body sensors of environment induction module control are attached to gene sequencer Near user is sensed.
As an improvement, the gene sequencer forces cleaning system to further comprise parameter calling module, for performing Multiple environmental parameters that last cleaning uses in cleaning daily record are read before automatic cleaning function.
As an improvement, the gene sequencer is pumped including nine holes, the automatic cleaning function is carried out for nine holes pump.
Compared with the prior art, gene sequencer cleaning method of the invention and system pre-establish Mission Monitor queue, At the end of previous gene sequencing task, when judging the interval of the latter gene sequencing task and previous gene sequencing task Between if beyond threshold value, display one chooses whether to perform the automatic cleaning startup interface of automatic cleaning function for user, convenient User selection the liquid channel system of equipment is cleaned, if while interval time without departing from threshold value, wait the latter gene Tasks carrying is sequenced, saves unnecessary cleaning link, the progress of multiple tasks is sequenced in accelerated gene.When all gene sequencing are appointed At the end of business, automatic spring shows an automatic cleaning startup interface, and user's selection is facilitated to clean equipment.Meanwhile work as institute State of the automatic cleaning startup interface without operation response is stated more than automatic cleaning function is performed after the default time limit, solves user people The problem of forgetting to clean liquid channel system for error.Further, before automatic cleaning function is performed, gene sequencing of the invention Instrument cleaning method and system have further determined whether user at the scene, when the situation of user not at the scene just cleans fluid path automatically System further ensures the accurately and timely property cleaned automatically, the multiple gene sequencing work that interference is avoided to be carried out continuously.
Description of the drawings
Fig. 1 is the flow diagram of first embodiment of the invention gene sequencer cleaning method.
Fig. 2 is the flow diagram of second embodiment of the invention gene sequencer cleaning method.
Fig. 3 is the flow diagram of third embodiment of the invention gene sequencer cleaning method.
Fig. 4 is the flow diagram of four embodiment of the invention gene sequencer cleaning method.
Fig. 5 is the running environment schematic diagram that an embodiment of the present invention gene sequencer forces cleaning system.
Specific embodiment
In order to make the purpose , technical scheme and advantage of the present invention be clearer, below in conjunction with drawings and the embodiments, The present invention will be described in further detail.
Fig. 1 is the flow diagram of first embodiment of the invention gene sequencer cleaning method, and the gene sequencer is clear Washing method includes step S11- steps S13.
Queue establishment step S11 establishes Mission Monitor queue according to the sequencing of multiple gene sequencing tasks.This implementation In example, a Mission Monitor interface can be provided on the display of gene sequencer, assists user according to the priority for using equipment Sequentially input type and the time for the gene sequencing for needing to carry out.Gene sequencer in the present embodiment is second generation high throughput base Because of sequenator.
Judgment step S12 is spaced, at the end of previous gene sequencing task, judges the latter gene sequencing task with before Whether the interval time of one gene sequencing task exceeds threshold value.In the present embodiment, in order to avoid between two gene sequencing tasks Every overlong time, there is exception without cleaning for a long time, the interval time of two tasks is judged in liquid channel system.This implementation In example, the interval time is that previous gene sequencing task actual finish time and the latter gene sequencing task scheduling start The interval time of both time.
Interface Eject step S13 shows that one chooses whether to perform certainly for user if the interval time is beyond threshold value The automatic cleaning startup interface of dynamic cleaning function, otherwise waits for the latter gene sequencing task start.In the present embodiment, by appointing Business monitoring interface, user can in advance make choice different genes sequencing task, and the gene sequencing task includes sequencing Terminate flow.It is performed when the sequencing terminates flow, with pop-up in the display device of gene sequencer control system Form shows an automatic cleaning startup interface.In the present embodiment, the automatic cleaning startup interface includes multiple parameters and sets column Position, for automatic cleaning function to be selected to be performed multiple environmental parameters of needs.In preferred embodiment, the environmental parameter includes Cleaning object, cleaning fluid volume, cleaning temperature etc..
Compared with the prior art, gene sequencer cleaning method of the invention pre-establishes Mission Monitor queue, when previous At the end of a gene sequencing task, if judging the interval time of the latter gene sequencing task and previous gene sequencing task Beyond threshold value, then show that one chooses whether to perform the automatic cleaning startup interface of automatic cleaning function for user, user is facilitated to select Select and equipment cleaned, if while interval time without departing from threshold value, wait the latter gene sequencing tasks carrying, save The progress of multiple tasks is sequenced in unnecessary cleaning link, accelerated gene.
Fig. 2 is the flow diagram of second embodiment of the invention gene sequencer cleaning method, and the gene sequencer is clear Washing method includes step S11- steps S15.
Queue establishment step S11 establishes Mission Monitor queue according to the sequencing of multiple gene sequencing tasks.This implementation In example, a Mission Monitor interface can be provided on the display of gene sequencer, assists user according to the priority for using equipment Sequentially input type and the time for the gene sequencing for needing to carry out.Gene sequencer in the present embodiment is second generation high throughput base Because of sequenator.
Judgment step S12 is spaced, at the end of previous gene sequencing task, judges the latter gene sequencing task with before Whether the interval time of one gene sequencing task exceeds threshold value.In the present embodiment, in order to avoid between two gene sequencing tasks Every overlong time, there is exception without cleaning for a long time, the interval time of two tasks is judged in liquid channel system.This implementation In example, the interval time is that previous gene sequencing task actual finish time and the latter gene sequencing task scheduling start The interval time of both time.
Interface Eject step S13 shows that one chooses whether to perform certainly for user if the interval time is beyond threshold value The automatic cleaning startup interface of dynamic cleaning function, otherwise waits for the latter gene sequencing task start.In the present embodiment, by appointing Business monitoring interface, user can in advance make choice different genes sequencing task, and the gene sequencing task includes sequencing Terminate flow.It is performed when the sequencing terminates flow, with pop-up in the display device of gene sequencer control system Form shows an automatic cleaning startup interface.In the present embodiment, the automatic cleaning startup interface includes multiple parameters and sets column Position, for automatic cleaning function to be selected to be performed multiple environmental parameters of needs.In preferred embodiment, the environmental parameter includes Cleaning object, cleaning fluid volume, cleaning temperature etc..
Timed process S14 is responded, timing is carried out to state of the automatic cleaning startup interface without operation response.This implementation In example, the automatic cleaning startup interface includes a confirming button and cancel button, starts to hold after user clicks confirming button Row cleaning function.Cleaning function is not performed when user clicks cancel button.In the present embodiment, system starts boundary to cleaning automatically It is not responded to after the pop-up of face or unattended situation carries out timing, more than execution step S15 after the default time limit.
Automatic cleaning step S15, the timing are more than to perform automatic cleaning function after presetting the time limit.In the present embodiment, institute Stating gene sequencer includes liquid channel system, and the automatic cleaning function is the liquid channel system for being directed to gene sequencer, especially The nine holes pump of liquid channel system carries out.Nine holes pump the core equipment as liquid channel system, and precise structure is led if as forgetting to clean Reaction reagent raffinate solidification and crystallization in the pump of nine holes is caused, liquid channel system can be caused, which to block, influences gene sequencer normal use.This reality It applies in example, automatic cleaning function is performed to gene sequencer using default environmental parameter.
In alternate embodiment, after the default time limit, before starting to perform automatic cleaning function, a ginseng can be further performed Number invocation step cleans multiple environmental parameters that last cleaning uses in daily record, using these parameters to gene for reading Sequenator performs automatic cleaning function.
Compared with the prior art, gene sequencer cleaning method of the invention pre-establishes Mission Monitor queue, when previous At the end of a gene sequencing task, if judging the interval time of the latter gene sequencing task and previous gene sequencing task Beyond threshold value, then show that one chooses whether to perform the automatic cleaning startup interface of automatic cleaning function for user, user is facilitated to select Select and equipment cleaned, if while interval time without departing from threshold value, wait the latter gene sequencing tasks carrying, save The progress of multiple tasks is sequenced in unnecessary cleaning link, accelerated gene.Further, gene sequencer cleaning side of the invention Method performs automatic cleaning function after state of the interface without operation response is more than the default time limit, reduces human error and forgets The problem of cleaning the liquid channel system of gene sequencer.
Fig. 3 is the flow diagram of third embodiment of the invention gene sequencer cleaning method.The gene sequencer is clear Washing method includes step S11- steps S16.
Queue establishment step S11 establishes Mission Monitor queue according to the sequencing of multiple gene sequencing tasks.This implementation In example, a Mission Monitor interface can be provided on the display of gene sequencer, assists user according to the priority for using equipment Sequentially input type and the time for the gene sequencing for needing to carry out.Gene sequencer in the present embodiment is second generation high throughput base Because of sequenator.
Judgment step S12 is spaced, at the end of previous gene sequencing task, judges the latter gene sequencing task with before Whether the interval time of one gene sequencing task exceeds threshold value.In the present embodiment, in order to avoid between two gene sequencing tasks Every overlong time, there is exception without cleaning for a long time, the interval time of two tasks is judged in liquid channel system.This implementation In example, the interval time is that previous gene sequencing task actual finish time and the latter gene sequencing task scheduling start The interval time of both time.
Interface Eject step S13 shows that one chooses whether to perform certainly for user if the interval time is beyond threshold value The automatic cleaning startup interface of dynamic cleaning function, otherwise waits for the latter gene sequencing task start.In the present embodiment, by appointing Business monitoring interface, user can in advance make choice different genes sequencing task, and the gene sequencing task includes sequencing Terminate flow.It is performed when the sequencing terminates flow, with pop-up in the display device of gene sequencer control system Form shows an automatic cleaning startup interface.In the present embodiment, the automatic cleaning startup interface includes multiple parameters and sets column Position, for automatic cleaning function to be selected to be performed multiple environmental parameters of needs.In preferred embodiment, the environmental parameter includes Cleaning object, cleaning fluid volume, cleaning temperature etc..
Timed process S14 is responded, timing is carried out to state of the automatic cleaning startup interface without operation response.This implementation In example, the automatic cleaning startup interface includes a confirming button and cancel button, starts to hold after user clicks confirming button Row cleaning function.Cleaning function is not performed when user clicks cancel button.In the present embodiment, system starts boundary to cleaning automatically It is not responded to after the pop-up of face or unattended situation carries out timing, more than execution step S16 after the default time limit.
Environment induction step S16, whether sensing gene sequencer nearby has user, if it is determined that gene sequencer nearby has User then re-executes response timed process S14, user is waited to being operated to cleaning startup interface automatically, if it is determined that base Because sequenator does not nearby have user then to perform automatic cleaning step S15.In the present embodiment, the environment induction step uses one Or multiple infrared human body sensors sense the user near gene sequencer.In preferred embodiment, it is one or The top in house where multiple infrared human body sensors may be mounted at sequenator.
Automatic cleaning step S15, timing be more than the default time limit and nobody be located near sequenator, perform and clean work(automatically Energy.In the present embodiment, the gene sequencer includes liquid channel system, and the automatic cleaning function is for gene sequencer The nine holes pump of liquid channel system, especially liquid channel system carries out.Core equipment of the nine holes pump as liquid channel system, precise structure, such as For fruit because forgetting that cleaning causes reaction reagent raffinate solidification and crystallization in the pump of nine holes, liquid channel system can be caused, which to block, influences gene sequencing Instrument normal use.In the present embodiment, automatic cleaning function is performed to gene sequencer using default environmental parameter.
In alternate embodiment, after the default time limit, before starting to perform automatic cleaning function, a ginseng can be further performed Number invocation step cleans multiple environmental parameters that last cleaning uses in daily record, using these parameters to gene for reading Sequenator performs automatic cleaning function.
Compared with aforementioned embodiments, before automatic cleaning function is performed, gene sequencer cleaning method of the invention User is further determined whether after being more than to preset the time limit in state of the interface without operation response at the scene, when user does not exist The situation at scene just cleans liquid channel system automatically, has not only ensured the cleaning of liquid channel system and unobstructed, also further ensure from The accurately and timely property of dynamic cleaning avoids the normal operation selection of interference user, prevents from interrupting the multiple gene sequencing being carried out continuously Work.
In alternate embodiment, can also timing be carried out to the situation of user not at the scene, when the situation of user not at the scene surpasses Automatic cleaning function is just performed after crossing preset time.
Fig. 4 be four embodiment of the invention gene sequencer cleaning method flow diagram, the present embodiment include with Lower step.
Queue establishment step S11 establishes Mission Monitor queue according to the sequencing of multiple gene sequencing tasks.This implementation In example, a Mission Monitor interface can be provided on the display of gene sequencer, assists user according to the priority for using equipment Sequentially input type and the time for the gene sequencing for needing to carry out.Gene sequencer in the present embodiment is second generation high throughput base Because of sequenator.
Cleaning step S17 after queue, after judging all gene sequencing tasks, the display automatic cleaning starts Interface.In the present embodiment, when all gene sequencing tasks in Mission Monitor queue all after the completion of, gene sequencer control be Cleaning startup interface, prompting user clean equipment automatically for display one in the form of pop-up in the display device of system.This reality It applies in example, the automatic cleaning startup interface can include the text window or alert flag of reminding user.In the present embodiment, institute Stating automatic cleaning startup interface includes multiple parameters setting field, for automatic cleaning function to be selected to be performed multiple rings of needs Border parameter.In preferred embodiment, the environmental parameter includes cleaning object, cleaning fluid volume, cleaning temperature etc..
Timed process S14 is responded, timing is carried out to state of the automatic cleaning startup interface without operation response.This implementation In example, the automatic cleaning startup interface includes a confirming button and cancel button, starts to hold after user clicks confirming button Row cleaning function.Cleaning function is not performed when user clicks cancel button.In the present embodiment, system starts boundary to cleaning automatically It is not responded to after the pop-up of face or unattended situation carries out timing, more than execution step S16 after the default time limit.
Environment induction step S16, whether sensing gene sequencer nearby has user, if it is determined that gene sequencer nearby has User then re-executes response timed process S14, user is waited to being operated to cleaning startup interface automatically, if it is determined that base Because sequenator does not nearby have user then to perform automatic cleaning step S15.In the present embodiment, the environment induction step S16 is used One or more infrared human body sensors sense the user near gene sequencer.In preferred embodiment, described one The top in house where a or multiple infrared human body sensors may be mounted at sequenator.
Automatic cleaning step S15, timing be more than the default time limit and nobody be located near sequenator, perform and clean work(automatically Energy.In the present embodiment, the gene sequencer includes liquid channel system, and the automatic cleaning function is for gene sequencer The nine holes pump of liquid channel system, especially liquid channel system carries out.Core equipment of the nine holes pump as liquid channel system, precise structure, such as For fruit because forgetting that cleaning causes reaction reagent raffinate solidification and crystallization in the pump of nine holes, liquid channel system can be caused, which to block, influences gene sequencing Instrument normal use.In the present embodiment, automatic cleaning function is performed to gene sequencer using default environmental parameter.
In alternate embodiment, after the default time limit, before starting to perform automatic cleaning function, a ginseng can be further performed Number invocation step cleans multiple environmental parameters that last cleaning uses in daily record, using these parameters to gene for reading Sequenator performs automatic cleaning function.
Compared with aforementioned embodiments, at the end of the present embodiment works as all gene sequencing tasks, automatic spring shows one certainly Dynamic cleaning startup interface, facilitates user's selection to clean equipment.Meanwhile when the automatic cleaning startup interface is rung without operation The state answered is more than to perform automatic cleaning function after presetting the time limit, solves user's human error and forgets to clean asking for liquid channel system Topic.Further, before automatic cleaning function is performed, gene sequencer cleaning method of the invention and system determine whether Whether there is user at the scene, when the situation of user not at the scene just cleans liquid channel system automatically, further ensure automatic cleaning Accurately and timely property, avoid interference be carried out continuously multiple gene sequencing work.
Fig. 5 is the running environment schematic diagram that one embodiment of the invention gene sequencer forces cleaning system.The present invention provides Gene sequencer force cleaning system 100 and its inside module can be have specific function embedded integration chip or The software code performed in write-in memory 500 by processor 400.
The gene sequencer forces cleaning system 100 to establish module 110, interval judgment module 120, interface including queue Pop-up module 130, response timing module 140, environment induction module 150 and cleaning starting module 160.
The queue establishes module 110 for establishing Mission Monitor team according to the sequencing of multiple gene sequencing tasks Row.In the present embodiment, a Mission Monitor interface can be provided on the display of gene sequencer, user is assisted to set according to using Standby sequencing input needs type and the time of the gene sequencing carried out.Gene sequencer in the present embodiment is the second generation High-throughput gene sequencer.
The interval judgment module 120 is used at the end of previous gene sequencing task, judges the latter gene sequencing Whether the interval time of task and previous gene sequencing task exceeds threshold value.In the present embodiment, in order to avoid two genes are surveyed Sequence task interval time is long, and liquid channel system exception occurs without cleaning for a long time, and the interval time of two tasks is sentenced It is disconnected.In the present embodiment, the interval time is that previous gene sequencing task actual finish time and the latter gene sequencing are appointed Business plan starts the interval time of both time.
The interface pop-up module 130 is used to then show that one chooses whether to hold for user beyond threshold value in the interval time The automatic cleaning startup interface of row automatic cleaning function, otherwise waits for the latter gene sequencing task start.In the present embodiment, lead to The Mission Monitor interface is crossed, user can in advance make choice different genes sequencing task, in the gene sequencing task Terminate flow including sequencing.It is performed when the sequencing of a certain gene sequencing task terminates flow, system is controlled in gene sequencer Startup interface is cleaned in display one automatically in the form of pop-up in the display device of system.In the present embodiment, the automatic cleaning starts Interface includes multiple parameters and sets field, for automatic cleaning function to be selected to be performed multiple environmental parameters of needs.It is preferably real It applies in example, the environmental parameter includes cleaning object, cleaning fluid volume, cleaning temperature etc..
In the present embodiment, the interface pop-up module 130 is further used for after all gene sequencing tasks, is shown Show the automatic cleaning startup interface.In the present embodiment, when all gene sequencing tasks in Mission Monitor queue all after the completion of, Startup interface is cleaned in display one automatically in the form of pop-up in the display device of gene sequencer control system, reminds user couple Equipment is cleaned.In the present embodiment, the automatic cleaning startup interface can include text window or the warning of reminding user Mark.
The response timing module 140 is based on carrying out state of the automatic cleaning startup interface without operation response When.In the present embodiment, the automatic cleaning startup interface includes a confirming button and cancel button, when user clicks confirming button After start perform cleaning function.Cleaning function is not performed when user clicks cancel button.In the present embodiment, system is to automatic clear It is not responded to after washing startup interface pop-up or unattended situation carries out timing.
Whether the environment induction module 150 has user for sensing near gene sequencer.In the present embodiment, the ring Border sensing step senses the user near gene sequencer using one or more infrared human body sensors.It is preferably real It applies in example, the top in house where one or more of infrared human body sensors may be mounted at sequenator.
The cleaning starting module 160 is used to perform automatic cleaning function when the timing is more than default or be used for The timing be more than the default time limit and nobody be located near sequenator, execution automatic cleaning function.In the present embodiment, gene is surveyed Sequence instrument 200 includes liquid channel system, and the liquid channel system is small including liquid-transfering needle 210, reagent platform 220, fluid path pipeline 230, reaction Room 240, nine holes pump 250.The automatic cleaning function is carried out primarily directed to the liquid channel system of gene sequencer.Preferred embodiment In, the automatic cleaning function is carried out for nine holes pump 250.Nine holes pump 250 core equipment as liquid channel system, structure Precision causes reaction reagent raffinate solidification and crystallization in nine holes pump 250 if as forgetting to clean, liquid channel system can be caused to block shadow Ring gene sequencer normal use.In the present embodiment, automatic cleaning work(is performed to gene sequencer using default environmental parameter Energy.
In alternate embodiment, can further comprise a parameter calling module, for start perform automatic cleaning function before, Multiple environmental parameters that last cleaning uses in cleaning daily record are read, gene sequencer are carried out using these parameters automatic clear It washes.
In alternate embodiment, response timing module 120 can also to user, situation at the scene does not carry out timing, when user not Situation at the scene just performs automatic cleaning function more than cleaning starting module 130 after preset time.
Compared with the prior art, gene sequencer cleaning system 100 of the invention is established module 110 using queue and is built in advance Vertical Mission Monitor queue, at the end of previous gene sequencing task, interval judgment module 120 judges that the latter gene sequencing is appointed If the interval time of business and previous gene sequencing task is selected beyond threshold value, the display of interface pop-up module 130 one for user The automatic cleaning startup interface for whether performing automatic cleaning function is selected, user's selection is facilitated to clean equipment, is spaced simultaneously If the time without departing from threshold value, waits the latter gene sequencing tasks carrying, saves unnecessary cleaning link, accelerated gene The progress of multiple tasks is sequenced.At the end of all gene sequencing tasks, automatic spring shows an automatic cleaning startup interface, side Just equipment is cleaned in user's selection.Meanwhile it is described response timing module 140 be used for the automatic cleaning startup interface without The state of operation response carries out timing, is held after state of the automatic cleaning startup interface without operation response is more than the default time limit Row automatic cleaning function solves the problems, such as that user's human error is forgotten to clean liquid channel system.Further, it is automatic clear in execution It washes before function, gene sequencer cleaning system use environment induction module 150 of the invention has further determined whether user At the scene, the situation cleaning starting module 160 as user not at the scene just cleans liquid channel system automatically, further ensures automatic The accurately and timely property of cleaning, the multiple gene sequencing work that interference is avoided to be carried out continuously.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all essences in the present invention All any modification, equivalent and improvement made within refreshing and principle etc., should all be included in the protection scope of the present invention.

Claims (14)

1. a kind of gene sequencer cleaning method, including:
Queue establishment step establishes monitoring queue according to the sequencing of multiple gene sequencing tasks;
Judgment step is spaced, at the end of previous gene sequencing task, judges the latter gene sequencing task and previous base Because whether the interval time of sequencing task exceeds threshold value;
Interface Eject step shows that one chooses whether to perform automatic cleaning work(for user if the interval time is beyond threshold value The automatic cleaning startup interface of energy, otherwise waits for the latter gene sequencing task start.
2. gene sequencer cleaning method according to claim 1, which is characterized in that judge all gene sequencing task knots Shu Hou shows the automatic cleaning startup interface.
3. gene sequencer cleaning method according to claim 1 or 2, which is characterized in that further comprise responding timing Step carries out timing, after the timing is more than the default time limit to state of the automatic cleaning startup interface without operation response Perform automatic cleaning function.
4. gene sequencer cleaning method according to claim 1 or 2, which is characterized in that further comprise responding timing Step, it is further after the response timed process to state progress timing of the automatic cleaning startup interface without operation response Including environment induction step, for sensing whether gene sequencer nearby has user, if it is determined that useful near gene sequencer Family then re-executes response timed process, if the timing is more than the default time limit and judges that gene sequencer is not used nearby Family then performs automatic cleaning function.
5. gene sequencer cleaning method according to claim 4, which is characterized in that the environment induction step uses one A or multiple infrared human body sensors sense the user near gene sequencer.
6. gene sequencer cleaning method according to claim 1 or 2, which is characterized in that perform the automatic cleaning work( It can further comprise parameter call step before, multiple environmental parameters that last cleaning uses in daily record are cleaned for reading.
7. gene sequencer cleaning method according to claim 1, which is characterized in that the gene sequencer includes nine holes Pump, the automatic cleaning function are carried out for nine holes pump.
8. a kind of gene sequencer forces cleaning system, including:
Module is established in queue, and monitoring queue is established according to the sequencing of multiple gene sequencing tasks;
Judgment module is spaced, at the end of previous gene sequencing task, judges the latter gene sequencing task and previous base Because whether the interval time of sequencing task exceeds threshold value;
Interface pop-up module shows that one chooses whether to perform automatic cleaning work(for user if the interval time is beyond threshold value The automatic cleaning startup interface of energy, otherwise waits for the latter gene sequencing task start.
9. gene sequencer according to claim 8 forces cleaning system, which is characterized in that all gene sequencing task knots Shu Hou, the interface pop-up module further show the automatic cleaning startup interface.
10. gene sequencer according to claim 8 or claim 9 forces cleaning system, which is characterized in that further comprises responding Timing module carries out timing, when the timing is more than default to state of the automatic cleaning startup interface without operation response Automatic cleaning function is performed after limit.
11. gene sequencer according to claim 8 or claim 9 forces cleaning system, which is characterized in that further comprises responding Timing module and environment induction module, the response timing module are used for the automatic cleaning startup interface without operation response State carries out timing, and the environment induction step is for sensing whether gene sequencer nearby has user, if it is determined that gene is surveyed Sequence instrument nearby has user, then responds timing module reclocking, if the timing is more than the default time limit and judges gene sequencing Instrument does not nearby have user then to perform automatic cleaning function.
12. gene sequencer according to claim 11 forces cleaning system, which is characterized in that the environment induction module The one or more infrared human body sensors of control sense the user near gene sequencer.
13. gene sequencer according to claim 8 or claim 9 forces cleaning system, which is characterized in that further comprises parameter Calling module once cleans the multiple environment used ginseng for being read before automatic cleaning function is performed in cleaning daily record Number.
14. gene sequencer according to claim 8 forces cleaning system, which is characterized in that the gene sequencer bag Nine holes pump is included, the automatic cleaning function is carried out for nine holes pump.
CN201611038814.XA 2016-11-11 2016-11-11 Gene sequencer cleaning method and system Pending CN108067481A (en)

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Application publication date: 20180525