CN108061732A - A kind of wearable Intelligent urine check system and urine examination method - Google Patents
A kind of wearable Intelligent urine check system and urine examination method Download PDFInfo
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- CN108061732A CN108061732A CN201810048332.5A CN201810048332A CN108061732A CN 108061732 A CN108061732 A CN 108061732A CN 201810048332 A CN201810048332 A CN 201810048332A CN 108061732 A CN108061732 A CN 108061732A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
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Abstract
The invention discloses a kind of wearable Intelligent urine check system and urine examination methods.Including collecting layer, test layer, test layer includes test layer body, several biomarker reaction modules being embedded on test layer body, it is characterised in that：It further includes for qualitative or quantitative analysis biomarker reaction module reaction result intelligent measurement software, the collection channel that collecting layer includes self-locking module, connected with biomarker, self-locking module includes self-lock switch, expander, collection channel is vertical to be opened on expander, and the water imbibition of collection channel is more than the water imbibition of expander；Test layer is made of hydrophobic material.The present invention is in the case where not excess soaks, a small amount of urine is only needed it is ensured that each piece of biomarker reaction module can be soaked completely, ensure the accuracy of reaction result, can also qualitative and quantitative analysis carry out reaction result by intelligent measurement software simultaneously so that testing result is more accurate.
Description
Technical field
The present invention relates to medical diagnosis field of mechanical technique, are a kind of wearable Intelligent urine check systems specifically.
Background technology
In hospital, geriatric nursing home or family, most of medical workers usually carry out disease using test strips preliminary
Examination, such as the Multistix 10SG of the Siemens and Multistixor of Bayer, this plays the part of during the primary dcreening operation of clinical disease
Drill key player.But for (part) disability old man and the constant people of taking action, using test strips method can there are poles
Big is not convenient, and for this groups of people, they usually wear diaper, therefore diaper with test strips is combined and seems to become
A kind of body fluid detects the effective method of disease, and this biological fluid extracting mode have the characteristics that it is painless and portable.
Test strips are attached on the outside of diaper by patent US 9131893B2 health diagnosis systems and method, and with intelligently
Mobile phone 301APP analyzes result, and the index of test is increased 12 by this method, but test strips therein are adhered to
In diaper, since diaper is worn to it after a certain period of time, it can not ensure the color of test strips long-time stable, and two
Influence of the secondary or even multiple piss to the judgement of color does not provide final conclusion.
Patent US 9131893B2 propose a kind of sample collection and computing system based on diaper, for examining for disease
It is disconnected, but the equipment does not have self-locking system, and the secondary influence into urine is not set out.Swiss Med Wkly companies of Switzerland have developed
Test strips are sealed in diaper by a kind of product Tena U test based on diaper, the product by the self-locking module of equipment
In a specific fixed environment, for the preliminary examination of urinary tract infections, although its term of validity can reach 24 it is small when, should
Product is leucocyte and nitrite in qualitative detection urine, and function is more single, can not meet urine in clinic and give birth to
Manage the examination demand of index.
Patent CN105929148B disclose a kind of passive type body fluid sample examination based on paper diaper and verifying attachment and
Application method, in the apparatus, urine are entered from collecting layer in the path network in test layer, horizontal in passage path network
The hydrophilic channel of setting is entered in biomarker reaction module, so as to be carried out with the reagent in biomarker reaction module
Reaction.In the device, after urine will first pass through self-locking mode expander absorption in the block, enter back into hydrophilic pathway, very may be used
Biomarker reaction module can be caused not moistened self-locking module completely also with regard to self-locking, cause biomarker reaction module not
It can chromogenic reaction；The hydrophilic pathway is horizontally disposed simultaneously, and biomarker reaction module is located at the end of hydrophilic pathway
End, it is also possible to cause urine that cannot flow to biomarker reaction module or cannot uniformly moisten biomarker reaction
Module causes reaction inaccurate；The device can only qualitatively reaction detection as a result, can not quantitative reaction result.
The content of the invention
The present invention seeks to be intended to provide a kind of wearable Intelligent urine check system, in the case where not excess soaks,
A small amount of urine ensures the standard of reaction result it is ensured that each piece of biomarker reaction module can be soaked completely
True property, while can also qualitative and quantitative analysis carry out reaction result by intelligent measurement software so that testing result is more
What is added is accurate.
To realize above-mentioned technical purpose, the technical solution adopted by the present invention is as follows：
A kind of wearable Intelligent urine check system, including collecting layer, test layer, the test layer include test layer body,
Several biomarker reaction modules being embedded on the test layer body are further included for qualitative or quantitative analysis life
The intelligent measurement software of object marker reaction module reaction result, the collecting layer include self-locking module and the biological marker
The collection channel of object connection, the self-locking module include self-lock switch, expander, the collection channel it is vertical be opened in it is described
On expander, the water imbibition of the collection channel is more than the water imbibition of the expander；The test layer is made of hydrophobic material.
Using the invention of above-mentioned technical proposal, the water imbibition of collection channel is more than the water imbibition of expander so that expander
Rate of water absorption be less than collection channel rate, so as to expander expansion self-lock switch is closed when, guarantee have enough urine
Liquid is absorbed by biomarker reaction module, ensures enough wettings of biomarker reaction module；Collection channel is vertical
Be opened on expander this structure class and provide capillarity for urine, at the same along with urine its own gravity and
The water absorbing properties of collection channel so that urine can smoothly be flowed into each piece of biomarker reaction module, be further ensured that life
Enough wettings of object marker reaction module ensure the accuracy of result；Test layer made of hydrophobic material ensure that each life
It is not interfere with each other between object marker reaction module, is further ensured that the accuracy of reaction result；By intelligent measurement software to anti-
Should result carry out qualitative and quantitative analysis, the accuracy of result can be improved.
One kind as a kind of wearable Intelligent urine check system of the present invention is preferably filled with water conservancy diversion in the collection channel
Substance, the water imbibition of the water conservancy diversion substance are more than the water imbibition of the expander.
The addition of water conservancy diversion substance can increase capillarity, accelerate the urine catheterization speed of collection channel, ensure that urine can be with
Wetting biomarker reaction module enough.Optimal, water conservancy diversion substance is the one or more in non-woven fabrics or blotting paper.
Another kind as a kind of wearable Intelligent urine check system of the present invention does not preferably have in the upper surface of the expander
There is the region overlay thin film for opening up collection channel, the water imbibition of the film is less than the water imbibition of the expander.
Film can delay absorption of the expander to urine, ensure enough profits of each piece of biomarker reaction module
It is wet.Preferably, which is glassine paper or polymethyl methacrylate；Expander can be amylopectin, super water-absorbent polypropylene
Resin, poly, HP (MA-VAC-MMA), HP (MA-VAC) and its mixture.
Another as a kind of wearable Intelligent urine check system of the present invention is preferred, and the collection channel is located at the life
The surface of object marker reaction module.
The collection channel can make urine quickly go directly the center of biomarker reaction module, and make urine from center outward
Diffusion, ensures the uniform of reaction color, basis is provided for the accuracy of quantitative analysis.
Another as a kind of wearable Intelligent urine check system of the present invention is preferred, and the collecting layer is further included by hydrophobic
Cuboid framework made of material, the expander, collection channel, test layer are respectively positioned in the frame, the collection channel
It is enclosed and set with the expander by the frame.
Expander, collection channel, test layer are wrapped in it by cuboid framework made of hydrophobic material, are marked in biology
Will object reaction module is with after urine reaction, being locked in a closed environment, this closed environment can tissue reaction's mistake
Reagent block afterwards generates side reaction with air, simultaneously avoids the evaporation of color hydration substrate.
Preferably, the collection channel includes vertical section to another kind as a kind of wearable Intelligent urine check system of the present invention
With for covering the extended segment of the biomarker reaction module, water conservancy diversion object is filled in the vertical section and extended segment
Matter.
Extended segment ensures that under such structure urine energy substantially uniformity soaks biomarker reaction module.
Preferably, the intelligent measurement software includes using another kind as a kind of wearable Intelligent urine check system of the present invention
In the image capture module of acquisition standard color card and biomarker reaction module reaction result, framing module, image are saturating
Depending on modular converter, characteristic extracting module, data processing module, interpretation of result module.
Optimal, intelligent measurement software is the intelligent measurement software on mobile phone, can utilize the phase of mobile phone in itself
Machine carries out the acquisition of image.
As a kind of wearable Intelligent urine check system of the present invention another preferably, further include it is positioned at most surface layer, by
Surface filtration layer made of water wetted material, the surface filtration layer edge exceed the collecting layer, and the standard color card is pasted onto
The surface filtration layer exceeds the bottom surface in the collecting layer part region.
Standard color card is attached to surface filtration layer beyond the bottom surface in the collecting layer part region, standard can be gathered simultaneously
The image of colour atla and biomarker reaction module reaction color, while be also convenient for positioning the image of acquisition and feature carries
It takes.
Optimal, standard color card can be attached to surface filtration layer bottom surface around collecting layer or be attached to the both sides of collecting layer.
Another kind as a kind of wearable Intelligent urine check system of the present invention is preferred, on four angles of the standard color card
Identification code is provided with, for positioning of the framing module to image.Optimal, identification code is Quick Response Code or dot.
Another as a kind of wearable Intelligent urine check system of the present invention is preferred, and described image perspective modular converter leads to
It crosses using scale invariant feature conversion (scale-invariant feature transform, sift), SURF algorithm, BRISK
A kind of algorithm in algorithm or generalised Hough transform (generalized Hough transform) carries out image perspective and turns
It changes.
Another kind as a kind of wearable Intelligent urine check system of the present invention preferably, scheme by the characteristic extracting module extraction
Biomarker reaction module and the characteristic corresponding to standard color card, characteristic RGB, sRGB, LMS, Von as in
One kind in Kries LMS, XYZ.
Another as a kind of wearable Intelligent urine check system of the present invention is preferred, and the data processing module is to be based on
The similarity of biomarker reaction module color and corresponding standard color card realizes biomarker quantitative and semi-quantitative
Judgement, level corresponding to the highest standard color card of similarity is the level of the biomarker in urine, image similarity
Comparison using linear discriminant (linear discriminant analysis, LDA), secondary discrimination (quadratic
Discriminant analysis, QDA) or K mean cluster method (k-means clustering) in a kind of method.
Intelligent measurement software is used to extract the characteristic color of the colour code on biomarker reaction module and standard color card, figure
As the process of processing includes characteristic extraction and image similarity compares, the characteristic using color space,
Can be RGB, sRGB, LMS, scale invariant feature turn can be used before characteristic extraction in Von Kries LMS or XYZ
Change (scale-invariant feature transform, sift), SURF, BRISK or generalised Hough transform
(generalized Hough transform) scheduling algorithm pre-processes picture.Biomarker quantitative and semi-quantitative is sentenced
Disconnected method is the similarity based on biomarker reaction module color Yu corresponding standard color card, the highest standard of similarity
Level corresponding to color lump is the level of the biomarker in urine, and the comparison of image similarity is using linear discriminant
(linear discriminant analysis, LDA), secondary discrimination (quadratic discriminant analysis,
) or K mean cluster method (k-means clustering) QDA.
The present invention can guarantee that each piece of biomarker reaction module can obtain completely in the case where not excess soaks
Wetting, ensure the accuracy of reaction result, while qualitative and quantitative analysis can also be carried out to reaction result so that detect
As a result more precisely.
It is a further object of the present invention to provide a kind of urine examination method of wearable Intelligent urine check system, including walking as follows
Suddenly：
1) Image Acquisition takes out the present apparatus from diaper, by image capture module to standard color card and biology
Marker reaction module reaction result carries out Image Acquisition；
2) framing is converted with perspective, and framing module carries out fixation and recognition, perspective image conversion using identification code
Module using scale invariant feature conversion (scale-invariant feature transform, sift), SURF, BRISK or
A kind of algorithm in generalised Hough transform (generalized Hough transform) carries out perspective conversion to image；
3) feature extraction gathers and color lump and the characteristic corresponding to standard color card is reacted in image, and characteristic can
To be RGB, sRGB, LMS, one kind in Von Kries LMS or XYZ；
4) data processing, biomarker quantitative and semi-quantitative determination methods are based on biomarker reaction module color
With the similarity of corresponding standard color card, the level corresponding to the highest standard color block of similarity is the biological marker in urine
The level of object, the comparison of image similarity is using linear discriminant (linear discriminant analysis, LDA), secondary
Differentiate in (quadratic discriminant analysis, QDA) or K mean cluster method (k-means clustering)
One kind；
5) interpretation of result.
Description of the drawings
The present invention can be further illustrated by the nonlimiting examples that attached drawing provides；
Fig. 1 is a kind of three-dimensional exploded view of wearable Intelligent urine check system in embodiment 1；
Fig. 2 is a kind of structure diagram of wearable Intelligent urine check system in embodiment 1；
Fig. 3 is another structure diagram of self-lock switch in embodiment 1；
Fig. 4 is the structure diagram of the urine examination system in collection channel after addition water conservancy diversion substance in embodiment 1；
Fig. 5 is the structure diagram in a kind of wearable Intelligent urine check system in embodiment 2；
Fig. 6 is a kind of structure diagram of wearable Intelligent urine check system in embodiment 3；
Fig. 7 is a kind of flow chart of wearable Intelligent urine check system detection method；
Fig. 8 is a kind of location diagram of standard color card；
Fig. 9 is another location diagram of standard color card；
Main element symbol description is as follows：
Surface filtration layer 1, standard color card 2, identification code 21, collecting layer 3, frame 31, entrance 311, self-locking module 32, self-locking
Switch 321, expander 322, collection channel 33, water conservancy diversion substance 331, vertical section 332, extended segment 333, test layer 4, test layer sheet
Body 41, biomarker reaction module 42.
Specific embodiment
In order to make those skilled in the art that the present invention may be better understood, with reference to the accompanying drawings and examples to this hair
Bright technical solution further illustrates.
Embodiment 1
As depicted in figs. 1 and 2, a kind of wearable Intelligent urine check system, including be located at most surface layer by water wetted material system
Into surface filtration layer 1, be pasted onto the standard color card 2 of 1 bottom surface of surface filtration layer, collecting layer 3, test layer 4, for qualitative or
The intelligent measurement software of quantitative analysis biomarker reaction module reaction result.
Surface filtration layer 1 is made of non-woven fabrics or cotton, can effectively through urinary fractions and can effectively be filtered in diaper
Excrement residue, at the same time, the people that can make wearing diaper is more comfortable.Extend frame 31 in the edge of surface filtration layer 1
Top surface, standard color card 2 is pasted onto on the part region to extend out, can be pasted around collecting layer 3 as shown in figure 8,
Can also be the both sides for being pasted onto collecting layer 3, shown in Fig. 9.
Collecting layer 3 includes cuboid framework 31 made of transparent plastic, and self-locking module 32 is anti-with the biomarker
The collection channel 33 that module 42 is answered to connect；Wherein self-locking module 32, collection channel 33, test layer 4 are respectively positioned in frame 31.Frame
Urine inlet 311 is offered at 31 top center.Self-locking module 32 includes being mounted on the self-lock switch at urine inlet 311
321 and the expander 322 that is arranged on inside frame 31, urine expansion is absorbed by expander 322 and closes self-lock switch 321
It closes and achievees the purpose that self-locking, as shown in Figures 2 and 3, self-lock switch 321 can be rotatablely connected with entrance 311, can also be movable
It is arranged at entrance 311.Collection channel 33 is vertically arranged, and is enclosed and set with the expander 322 by the frame 31, directly with
Biomarker reaction module 42 connects, and this structure can provide capillarity for urine so that the water imbibition of collection channel 33
More than the water imbibition of expander 322, urine is made to penetrate into biomarker reaction module 42.As shown in figure 4, in order to further
Ensure the water conservancy diversion speed of urine, water conservancy diversion substance 331, such as non-woven fabrics, blotting paper etc. are filled in collection channel 33.In order to avoid
Self-locking occurs there is a situation where biomarker reaction module 42 does not soak completely also, in the upper surface of the expander 322
The region overlay thin film of collection channel is not opened up, the water imbibition of the film is less than the water imbibition of the expander 322,
The material of the film can be glassine paper or polymethyl methacrylate.
The test layer 4 includes test layer body 41, several biological markers being embedded on the test layer body 41
Object reaction module 42, test layer body 41 are made of hydrophobic material, positioned at the bottom of frame 31.Frame 31 wraps test layer 4
It is rolled in wherein, it can be protected, biomarker reaction module 42 with the biomarker in urine after reacting, institute
Some reagent blocks are locked in a closed environment, and the reagent block that this closed environment can be after tissue reaction is generated with air
Side reaction simultaneously avoids the evaporation of color hydration substrate.
The intelligent measurement software includes gathering standard color card 2 and 42 reaction result of biomarker reaction module
Image capture module, framing module, perspective image modular converter, characteristic extracting module, data processing module, interpretation of result
Module.
As shown in Figure 8, Figure 9, identification code 21 is provided on four angles of the standard color card 2, for framing module
Positioning to image.The identification code can be dot or Quick Response Code
Described image perspective modular converter converts (scale-invariant feature by using scale invariant feature
Transform, sift), SURF algorithm, BRISK algorithms or generalised Hough transform (generalized Hough transform)
In a kind of algorithm perspective conversion is carried out to image.
Biomarker reaction module and the characteristic corresponding to standard color card in characteristic extracting module extraction image
According to one kind in characteristic RGB, sRGB, LMS, Von Kries LMS, XYZ.
The data processing module is similar to corresponding standard color card based on biomarker reaction module color
It spends to realize
The judgement of biomarker quantitative and semi-quantitative, the level corresponding to the highest standard color card of similarity is in urine
The level of the biomarker, the comparison of image similarity using linear discriminant (linear discriminant analysis,
LDA), secondary discrimination (quadratic discriminant analysis, QDA) or K mean cluster method (k-means
Clustering one kind in).
Embodiment 2
As shown in figure 5, a kind of wearable Intelligent urine check system, the table made of water wetted material including being located at most surface layer
Face filter layer 1 is pasted onto the standard color card 2 of 1 bottom surface of surface filtration layer, collecting layer 3, test layer 4, for qualitative or quantitative point
Analyse the intelligent measurement software of 42 reaction result of biomarker reaction module.
Surface filtration layer 1 is made of non-woven fabrics or cotton, can effectively through urinary fractions and can effectively be filtered in diaper
Excrement residue, at the same time, the people that can make wearing diaper is more comfortable.Extend frame 31 in the edge of surface filtration layer 1
Top surface, standard color card 2 is pasted onto on the part region to extend out, can be pasted around collecting layer 3 as shown in figure 8,
Can also be the both sides for being pasted onto collecting layer 3, shown in Fig. 9, the present embodiment uses structure shown in Fig. 8.
Collecting layer 3 includes cuboid framework 31 made of transparent plastic, and self-locking module 32 is anti-with the biomarker
The collection channel 33 that module 42 is answered to connect；Wherein self-locking module 32, collection channel 33, test layer 4 are respectively positioned in frame 31.Frame
Urine inlet 311 is offered at 31 top center.Self-locking module 32 includes being mounted on the self-lock switch at urine inlet 311
321 and the expander 322 that is arranged on inside frame 31, urine expansion is absorbed by expander 322 and closes self-lock switch 321
It closes and achievees the purpose that self-locking.Collection channel 33 is vertically arranged, and is enclosed and set with the expander 322 by the frame 31, directly
It is connected with biomarker reaction module 42, this structure can provide capillarity for urine so that the water suction of collection channel 33
Property be more than expander 322 water imbibition, urine is made to penetrate into biomarker reaction module 42.In order to further ensure urine
Water conservancy diversion speed, water conservancy diversion substance 331, such as non-woven fabrics, blotting paper etc. are filled in collection channel 33.In order to further avoid giving birth to
Object marker reaction module 42 cannot uniform chromogenic reaction, collection channel 33 includes vertical section 332 and for covering the biology
The extended segment 333 of marker reaction module 42 is filled with water conservancy diversion substance 331 in the vertical section 332 and extended segment 333.For
It avoids that self-locking does not occur completely there is a situation where biomarker reaction module 42 does not soak also, in the expander 322
Upper surface does not open up the region overlay thin film of collection channel 33, and the water imbibition of the film is less than the expander 322
Water imbibition, the material of the film can be glassine paper or polymethyl methacrylate.
The test layer 4 includes test layer body 41, several biological markers being embedded on the test layer body 41
Object reaction module 42, test layer body 41 are made of hydrophobic material, positioned at the bottom of frame 31.Frame 31 wraps test layer 4
It is rolled in wherein, it can be protected, biomarker reaction module 42 with the biomarker in urine after reacting, institute
Some reagent blocks are locked in a closed environment, and the reagent block that this closed environment can be after tissue reaction is generated with air
Side reaction simultaneously avoids the evaporation of color hydration substrate.
The intelligent measurement software includes gathering standard color card 2 and 42 reaction result of biomarker reaction module
Image capture module, framing module, perspective image modular converter, characteristic extracting module, data processing module, interpretation of result
Module.
As shown in Figure 8, Figure 9, identification code 21 is provided on four angles of the standard color card 2, for framing module
Positioning to image.
Described image perspective modular converter converts (scale-invariant feature by using scale invariant feature
Transform, sift), SURF algorithm, BRISK algorithms or generalised Hough transform (generalized Hough transform)
In a kind of algorithm perspective conversion is carried out to image.
Biomarker reaction module 42 and the feature corresponding to standard color card 2 in characteristic extracting module extraction image
Data, one kind in characteristic RGB, sRGB, LMS, Von Kries LMS, XYZ.
The data processing module is the phase based on 42 color of biomarker reaction module with corresponding standard color card 2
The judgement of biomarker quantitative and semi-quantitative is realized like degree, the level corresponding to the highest standard color card 2 of similarity is urine
The level of the biomarker in liquid, the comparison of image similarity use linear discriminant (linear discriminant
Analysis, LDA), secondary discrimination (quadratic discriminant analysis, QDA) or K mean cluster method (k-
Means clustering) in one kind.
Embodiment 3
As shown in fig. 6, a kind of wearable Intelligent urine check system, the table made of water wetted material including being located at most surface layer
Face filter layer 1 is pasted onto the standard color card 2 of 1 bottom surface of surface filtration layer, collecting layer 3, test layer 4, for qualitative or quantitative point
Analyse the intelligent measurement software of 42 reaction result of biomarker reaction module.
Surface filtration layer 1 is made of non-woven fabrics or cotton, can effectively through urinary fractions and can effectively be filtered in diaper
Excrement residue, at the same time, the people that can make wearing diaper is more comfortable.Extend frame 31 in the edge of surface filtration layer 1
Top surface, standard color card 2 is pasted onto on the part region to extend out, can be pasted around collecting layer 3 as shown in figure 8,
Can also be the both sides for being pasted onto collecting layer 3, shown in Fig. 9, the present embodiment uses structure shown in Fig. 8.
Collecting layer 3 includes cuboid framework 31 made of transparent plastic, and self-locking module 32 is anti-with the biomarker
The collection channel 33 that module 42 is answered to connect；Wherein self-locking module 32, collection channel 33, test layer 4 are respectively positioned in frame 31.Frame
Urine inlet 311 is offered at 31 top center.Self-locking module 32 includes being mounted on the self-lock switch at urine inlet 311
321 and the expander 322 that is arranged on inside frame 31, urine expansion is absorbed by expander 322 and closes self-lock switch 321
It closes and achievees the purpose that self-locking.Collection channel 33 is vertically arranged, and is directly opened on expander 322, is reacted positioned at biomarker
The surface of module is directly connected with biomarker reaction module 42, and this structure can provide capillarity for urine so that
The water imbibition of collection channel 33 is more than the water imbibition of expander 322, and urine is made to penetrate into biomarker reaction module 42.For
It is further ensured that the water conservancy diversion speed of urine, water conservancy diversion substance 331, such as non-woven fabrics, blotting paper etc. is filled in collection channel 33.
Self-locking occurs in order to avoid not soaked completely also there is a situation where biomarker reaction module 42, in the expander 322
Upper surface do not open up the region overlay thin film of collection channel 33, the water imbibition of the film is less than the expander
322 water imbibition, the material of the film can be glassine paper or polymethyl methacrylate.
The test layer 4 includes test layer body 41, several biological markers being embedded on the test layer body 41
Object reaction module 42, test layer body 41 are made of hydrophobic material, positioned at the bottom of frame 31.Frame 31 wraps test layer 4
It is rolled in wherein, it can be protected, biomarker reaction module 42 with the biomarker in urine after reacting, institute
Some reagent blocks are locked in a closed environment, and the reagent block that this closed environment can be after tissue reaction is generated with air
Side reaction simultaneously avoids the evaporation of color hydration substrate.
The intelligent measurement software includes gathering standard color card 2 and 42 reaction result of biomarker reaction module
Image capture module, framing module, perspective image modular converter, characteristic extracting module, data processing module, interpretation of result
Module.
As shown in Figure 8, Figure 9, identification code 21 is provided on four angles of the standard color card 2, for framing module
Positioning to image.
Described image perspective modular converter converts (scale-invariant feature by using scale invariant feature
Transform, sift), SURF algorithm, BRISK algorithms or generalised Hough transform (generalized Hough transform)
In a kind of algorithm perspective conversion is carried out to image.
Biomarker reaction module 42 and the feature corresponding to standard color card 2 in characteristic extracting module extraction image
Data, one kind in characteristic RGB, sRGB, LMS, Von Kries LMS, XYZ.
The data processing module is the phase based on 42 color of biomarker reaction module with corresponding standard color card 2
The judgement of biomarker quantitative and semi-quantitative is realized like degree, the level corresponding to the highest standard color card 2 of similarity is urine
The level of the biomarker in liquid, the comparison of image similarity use linear discriminant (linear discriminant
Analysis, LDA), secondary discrimination (quadratic discriminant analysis, QDA) or K mean cluster method (k-
Means clustering) in one kind.
It is used in use, the present apparatus is covered on diaper, the present invention also provides the urine examination method of the device, such as Fig. 7 institutes
Show, be as follows：
1) Image Acquisition takes out the present apparatus from diaper, by image capture module to standard color card 2 and biology
42 reaction result of marker reaction module carries out Image Acquisition；
2) framing is converted with perspective, and framing module carries out fixation and recognition using identification code 21, and perspective image turns
Block is changed the mold using scale invariant feature conversion (scale-invariant feature transform, sift), SURF, BRISK
Or algorithm carries out perspective conversion to image in one in generalised Hough transform (generalized Hough transform)；
3) feature extraction gathers and color lump and the characteristic corresponding to standard color card 2 is reacted in image, and characteristic can
To be RGB, sRGB, LMS, one kind in Von Kries LMS or XYZ；
4) data processing, biomarker quantitative and semi-quantitative determination methods are based on 42 face of biomarker reaction module
The similarity of color and corresponding standard color card 2, the level corresponding to the highest standard color block of similarity are the biology in urine
The level of marker, the comparison of image similarity using linear discriminant (linear discriminant analysis, LDA),
Secondary discrimination (quadratic discriminant analysis, QDA) or K mean cluster method (k-means
Clustering) one kind of kind；
5) interpretation of result.
A kind of wearable Intelligent urine check system provided by the invention and urine examination method are described in detail above.Tool
The explanation of body embodiment is only intended to help the method and its core concept for understanding the present invention.It should be pointed out that it is led for this technology
For the those of ordinary skill in domain, without departing from the principle of the present invention, can also to the present invention carry out it is several improvement and
Modification, these improvement and modification are also fallen into the protection domain of the claims in the present invention.
Claims (13)
1. a kind of wearable Intelligent urine check system, including collecting layer, test layer, the test layer includes test layer body, edge
Several biomarker reaction modules on the test layer body, it is characterised in that：Further include for qualitative or
The intelligent measurement software of quantitative analysis biomarker reaction module reaction result, the collecting layer include self-locking module and institute
State the collection channel of biomarker connection, the self-locking module includes self-lock switch, expander, and the collection channel is vertical
It is opened on the expander, the water imbibition of the collection channel is more than the water imbibition of the expander；The test layer is by dredging
Water material is made.
2. a kind of wearable Intelligent urine check system according to claim 1, it is characterised in that：It is filled out in the collection channel
Filled with water conservancy diversion substance, the water imbibition of the water conservancy diversion substance is more than the water imbibition of the expander.
3. a kind of wearable Intelligent urine check system according to claim 1 or 2, it is characterised in that：In the expander
Upper surface do not open up the region overlay thin film of collection channel, the water imbibition of the film is less than the suction of the expander
It is aqueous.
4. a kind of wearable Intelligent urine check system according to claim 3, it is characterised in that：The collection channel is located at
The surface of the biomarker reaction module.
5. a kind of wearable Intelligent urine check system according to claim 3, it is characterised in that：The collecting layer further includes
The cuboid framework made of hydrophobic material, the expander, collection channel, test layer are respectively positioned in the frame, the receipts
Collection passage is enclosed by the frame with the expander to be set.
6. a kind of wearable Intelligent urine check system according to claim 5, it is characterised in that：The collection channel includes
Vertical section and the extended segment for covering the biomarker reaction module, filled with leading in the vertical section and extended segment
Flow substance.
7. according to a kind of wearable Intelligent urine check system of 1,2,4,5,6 any one of them of claim, it is characterised in that：Institute
Stating intelligent measurement software includes the image capture module for gathering standard color card and biomarker reaction module reaction result,
Framing module, perspective image modular converter, characteristic extracting module, data processing module, interpretation of result module.
8. a kind of wearable Intelligent urine check system according to claim 7, it is characterised in that：It further includes positioned at most surface layer
, the surface filtration layer made of water wetted material, the surface filtration layer edge exceed the collecting layer, and the standard color card glues
It is attached to the bottom surface that the surface filtration layer exceeds the collecting layer part region.
9. a kind of wearable Intelligent urine check system according to claim 8, it is characterised in that：The four of the standard color card
Identification code is provided on a angle, for positioning of the framing module to image.
10. a kind of wearable Intelligent urine check system according to claim 7, it is characterised in that：Described image perspective turns
Mold changing block converts (scale-invariant feature transform, sift) by using scale invariant feature, SURF is calculated
A kind of algorithm in method, BRISK algorithms, generalised Hough transform (generalized Hough transform) algorithm is to image
Carry out perspective conversion.
11. a kind of wearable Intelligent urine check system according to claim 7, it is characterised in that：The feature extraction mould
Biomarker reaction module and the characteristic corresponding to standard color card in block extraction image, characteristic RGB,
One kind in sRGB, LMS, Von Kries LMS, XYZ.
12. a kind of wearable Intelligent urine check system according to claim 7, it is characterised in that：The data processing mould
Block is to realize that biomarker is qualitative based on the similarity of biomarker reaction module color and corresponding standard color card
With the judgement of sxemiquantitative, the level corresponding to the highest standard color card of similarity is the level of the biomarker in urine, is schemed
As the comparison of similarity is using linear discriminant (linear discriminant analysis, LDA), secondary discrimination
One in (quadratic discriminant analysis, QDA) or K mean cluster method (k-means clustering)
Kind.
13. a kind of urine examination method of wearable Intelligent urine check system of claim 1-12 any one of them, which is characterized in that
Include the following steps：
1) Image Acquisition takes out the present apparatus, by image capture module to standard color card and biological marker from diaper
Object reaction module reaction result carries out Image Acquisition；
2) framing is converted with perspective, and framing module carries out fixation and recognition, perspective image modular converter using identification code
(scale-invariant feature transform, sift), SURF, BRISK or broad sense are converted using scale invariant feature
A kind of algorithm in Hough transformation (generalized Hough transform) carries out perspective conversion to image；
3) feature extraction gathers and color lump and the characteristic corresponding to standard color card is reacted in image, and characteristic is RGB,
One kind in sRGB, LMS, Von Kries LMS or XYZ；
4) data processing, biomarker quantitative and semi-quantitative determination methods are based on biomarker reaction module color and institute
The similarity of corresponding standard color card, the level corresponding to the highest standard color block of similarity are the biomarker in urine
Level, the comparison of image similarity is using linear discriminant (linear discriminant analysis, LDA), secondary discrimination
One in (quadratic discriminant analysis, QDA) or K mean cluster method (k-means clustering)
Kind method；
5) interpretation of result.
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