CN107981870A - A kind of tapon - Google Patents
A kind of tapon Download PDFInfo
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- CN107981870A CN107981870A CN201610956358.0A CN201610956358A CN107981870A CN 107981870 A CN107981870 A CN 107981870A CN 201610956358 A CN201610956358 A CN 201610956358A CN 107981870 A CN107981870 A CN 107981870A
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- sensor
- tapon
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- test strips
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150015—Source of blood
- A61B5/150045—Source of blood for blood from vagina, placenta, colon or mouth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150358—Strips for collecting blood, e.g. absorbent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/157—Devices characterised by integrated means for measuring characteristics of blood
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biophysics (AREA)
- Veterinary Medicine (AREA)
- Medical Informatics (AREA)
- Chemical & Material Sciences (AREA)
- Food Science & Technology (AREA)
- Urology & Nephrology (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Reproductive Health (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
The invention discloses a kind of tapon, the one or more that are loaded with the tapon in Intelligent sensing device, test strips or enriching apparatus.Contain sensor, wireless signal transmission and power supply unit in the Intelligent sensing device.The signal of the physics detected in menses, chemistry, biology can be converted into electric signal by the sensor, electric signal is transmitted to electronic equipment by wireless signal transmission, the software of electronic equipment analyzes and processes electrical signal data, finally draws the physiological and biochemical index of women.The enriching apparatus can collect menses, further detect physiological and biochemical index by third party's instrument, improve the accuracy of medical diagnosis on disease.This bright tapon can collect menses and collect and detect one, it can be achieved that the physiological and biochemical index of real-time, online non-invasi detection women.
Description
Technical field
The present invention relates to a kind of tapon, more particularly to it is a kind of collect or can in situ, real-time online detection through blood physiology
The tapon of biochemical indicator.
Background technology
The sampling and diagnosis of gynecological disease detection have damaging, time-lag effect and dependent on hospital and medical staff.
Such as in biochemical and biology checkout procedure, do it is damaging take blood, with blood constituent, various detection labels, cell
Etc. diagnosing, in pathological examination, damaging biopsy is done to cancerous tissue etc. and detection and analysis cellular level being no different
Often.In addition, in the detection in relation to urine, excrement, saliva etc., limited by sampling spot, testing location and inspection personnel.
The sampling and diagnosis of gynecological tumor detection, it is even more so.However, women specificity tumour occurred frequently, such as oophoroma, son
Palace cancer, cervical carcinoma and breast cancer, are always to endanger women's health and life in the world because its diagnosis hysteresis, lethality are high
A kind of fatal disease of life；Therefore, the disease including gynecological tumor is predicted early, diagnosed, to women's health and life
The maintenance and raising of bioplasm amount are significant.But shyness and painful topic due to women's diseases, patient is until diseased serious
Just go to a hospital to see a doctor, at this time, the golden hour of disease may be had already passed by.
Although the diagnosis of some gynecological tumors has not had damaging, such as the detection of cervical carcinoma, pass through HPV (human papilloma virus
Poison) detection and Pap smear, however, both detections are required to patient gathers sample to clinic, and have necessarily invasive, give
Patient causes sense of discomfort.
Therefore, development one kind is without invasive, damaging, time dependence, place dependence, testing staff's dependence, energy
Enough to diagnose the illness in advance, the detection device tool of especially gynecological tumor is of great significance.
Menstruation is that property endometrial cycle comes off and with bleeding.The main component of menses is blood, in addition, also containing uterus
The fragment of inner membrance, Ovulation prediction, vaginal epithelial cell and various organized enzymes and biotic factor etc..Therefore, menses are tumor-markers
Thing or the preferable sample of other diseases diagnosis.
Tapon carrys out the time of tide in feminine menstrual, can insert and menses are absorbed in vagina, because its it is dry and comfortable it is comfortable, be not easy to reveal,
Superpower suction enjoys great popularity abroad.The menses uptake of tapon is bigger than sanitary napkin, and volume is more compact, along with cotton wool
Bar is to insert to absorb menses in vagina, has certain isolation with external environment, thus tapon be more suitable as collection and
Analyze the carrier of menses.
However, so far, the function of tapon is only limited to absorb menses, can be enriched with without a tapon or
It is the physiological and biochemical index tested and analyzed in menses, to detect females physiologic status and health status.
The content of the invention
, being capable of in situ, real-time, on-line checking it is an object of the invention to provide a kind of tapon of Weight detector
Physiological and biochemical index in menses, so as to predict/physiological status, the health status of Diagnosis of Female.
It is tapon the present invention also aims to provide one kind containing enriching apparatus, collects menses, further lead to
Third party's Instrumental Analysis is crossed, confirms the generation of disease.
The purpose of the present invention is realized by following technological means：
The present invention provides a kind of tapon, take out line containing absorber and tapon, in tapon, be also loaded
Detection device and/or enriching apparatus.
The detection device is one kind or group in physical detection device, chemical detection devices or biological monitor
Close.
Preferably, the detection device is test strips, one kind in intelligent-induction device or its combination.
The test strips is can be test strips of the prior art, such as five Dry-type biochemical test strip, blood examinations
One or more in paper, whole blood urea bio-sensing test paper, determination of trace element test paper, HIV test paper etc..Can also be oneself
Design the test strips prepared.
In a preferred embodiment of the invention, the test strips are located in the absorber of tapon, and the upper end has
One injection port, injection port are located at the insertion end of tapon.There is a detection zone in test strips/test strips, detection zone can show inspection
Survey result.One pumping line, the extraction for test strips/test strips are arranged at test strips bottom.As preferred embodiment, whole test paper
Bar is except injection port and takes out line, remaining structure is in sealing state, to prevent the menses in tapon from influencing detection reaction.Use
When, menses contact the injection port of test strips, through capillary action, are reacted into detection zone and show result.Extract tapon out
Afterwards, then take out line by test strips and extract test strips out, you can observation testing result.
The Intelligent sensing device is located in the absorber of tapon.Intelligent sensing device includes sensor, wireless
Signal transmitting apparatus and power supply unit.
Preferably, a filtration apparatus is additionally provided with above the Intelligent sensing device, is sensor below filtration apparatus, warp
The filtered device of blood removes fragment of tissue and other impurities, then feeler, sensor by the physics in menses, chemistry,
The signal of biology is converted into electric signal, and electric signal is transmitted to electronic equipment, the software of electronic equipment by wireless signal transmission
Electric signal is analyzed and processed, finally draws the physiological and biochemical index of women.
Preferably, the sensor is MEMS sensor.
MEMS is micro electronic mechanical system (Micro-ElectroMechanicalSystem), and MEMS refers to
Can batch making, by micro mechanism, microsensor, micro actuator and signal processing and control circuit, until interface,
Communication and power supply etc. are in the microdevice or system of one.
The MEMS sensor is one in MEMS physical sensors, MEMS chemical sensors and MEMS biology sensors
Kind is several.
Or preferably, the MEMS sensor is micro-fluidic chip.Micro-fluidic chip (Microfluidics
Chip it is) that the basic operation units such as biology, chemistry, the sample preparation of medical analysis process, reaction, separation, detection are integrated into
On the chip of one piece of micro-meter scale, network is formed by microchannel, to control microfluid to run through whole system, it is complete to be automatically performed analysis
Process.
As the example of selectable micro-fluidic chip, the researcher such as University of Southern California of the U.S. is thin using heterogeneous integration
The mode of film miniature vertical Cavity surface transmitting laser (VCSEL) and silicon optoelectronic diode (Si-PD) designs fully enclosed
Soft micro-fluidic fluorescent optical sensor.
Preferably, the sensor is the one or more in physical sensors, chemical sensor and biology sensor.
The physical sensors are humidity sensor, temperature sensor, heat-sensitive sensor, weight sensor and volume pass
One or more in sensor.
The chemical sensor is ion sensitive sensor, gas sensor, pH sensors.
The biology sensor is microbiological sensor, immunosensor, tissus sensor, cell sensor, enzyme pass
One or more in sensor, nucleic acid sensor, Protein sensor.
By setting different sensors in Intelligent sensing device, various physiological and biochemical indexs in menses can be carried out
Detection.The physiological and biochemical index detected includes but not limited to the histocyte in menses, microorganism such as bacterium, fungi and disease
One kind or more in poison, protein such as tumor markers, HPV antigens and enzyme etc., trace element, pH, hormone, menstrual blood loss etc.
Kind.
As a kind of embodiment, it is tumor markers that the present invention, which is detected as physiological and biochemical index, such as C12 tumor-markers
One or more in thing, C12 tumor markerses are specially alpha-fetoprotein (AFP), carcinomebryonic antigen (CEA), neuronal specificity
It is enolase (NSE), glycogen 125 (CA125), glycogen 153 (CA153), glycogen 242 (CA242), glycogen 199 (CA199), preceding
Row gland specific antigen (PSA), free prostate gland specificity antigen (f-PSA), ferritin (FER), β-human chorionic gonadotropin's gland
Hormone (β-HCG), human growth hormone (HGH) (HGH).
As a kind of embodiment, the physiological and biochemical index that the present invention detects is one or several in six, sex hormone.Swash
Element six specially FSH (follicle-stimulating hormone (FSH)), LH (interstitialcellstimulating hormone (ICSH)), PRL (prolactin), E2 (estradiol), PROG is (pregnant
Ketone), T (stosterone).
As a kind of embodiment, the physiological and biochemical index that the present invention detects is one or several in five, thyroid gland,
Specially trilute (FT3), free thyroxine (FT4), thyrotropic hormone (TSH), thyroid gland peroxidating
Thing enzyme antibody (TPOAb), thyroglobulin antibody (TGAb).
As a kind of embodiment, the physiological and biochemical index that the present invention detects is pituitary six.
The sensor can be sensor of the prior art or self-designed sensor.
Sensor of the prior art such as document《Appoint and pardon biosensors and sensor [J] instrumental techniques and sensing
Device, 1987,3:006.》Middle report be commercialized or the enzyme sensor of Success in Experiment, immunosensor, bacterium sensor etc.
Deng biology sensor.The multipurpose enzyme sensor of further example such as Britain Provesta corp.；Japanese kermes
B.O.D sensors；The Fluorescence Polarised Immunoassay sensor (total estriol in measure blood plasma) in Britain Abbot laboratories etc..
In a preferred embodiment of the invention, the sensor is Protein sensor.
The Protein sensor includes protein chip.
Protein chip is one kind in solid support (filter membrane, gel, slide, nano microsphere, microwell plate, high molecular material
Deng) substantial amounts of probe proteins are fixed in surface according to the method that is pre-designed (can be antigen, antibody, acceptor, ligand, enzyme, substrate
Deng).The protein molecular and the chip that special marking (such as fluorochrome label) will be carried carry out incubation reaction, and probe can combine sample
Testing protein (such as tumor marker, HPV antigens) in product is simultaneously in combination, and then label is detected again.
Selectable protein chip has polytype, such as nano-array immuno-chip, liquid chip, surface-enhanced laser solution
Suction/ionization chip, surface plasma body resonant vibration detection chip, isotope marks detection chip, fluorescent marker detection chip, change
Learn shine detection chip, the immune labeled detection chip of enzyme, colloid gold label detection chip, optical interference membrane DNA chip etc..
As an exemplary example, protein chip of the invention is the chip of chemiluminescence detection.
The exemplary testing principle of chemiluminescence detection chip is as shown in Figure 7：Antibody binding horseradish peroxidase or alkali
Acid phosphatase, enzyme combination luminous agent, catalysis and decomposition luminous agent, generation one is extended to distribute light, and system is read by light quantum
System receives, and photomultiplier converts optical signal into electric signal and amplified.
Chemiluminescence has the specificity of fluorescence, while exciting light is not required, and avoids exciting light in fluorescence analysis, spuious
The influence of light, there is very high sensitivity.
As a preferred embodiment, Protein sensor of the invention contain chemiluminescence detection protein chip and
Photovoltaic converter and signal amplifier.
As an exemplary example, protein chip of the invention is fluorescent marker detection chip.
The exemplary testing principle of fluorescent marker detection chip is as shown in Figure 8：Determined antigen contact chip in menses
In insolubilized antibody-fluorescent labeled antibody, formed " insolubilized antibody-determined antigen-fluorescent labeled antibody " sandwich structure exempt from
Epidemic disease complex, under the irradiation of exciting light, fluorescent labeled antibody sends fluorescence, and then fluorescence signal is received and be converted into telecommunications
Number, then electric signal is analyzed and processed.
As a preferred embodiment, the Protein sensor contains protein chip, exciting light sources, dichroic
Optical filter, lens, photovoltaic converter and signal amplifier.
Further, the protein chip is located at the lower section of filtration apparatus；The protein chip, dichroic filter
Piece, lens and photovoltaic converter are in same straight line successively；Photovoltaic converter is connected with signal amplifier by circuit.
Being fixed with protein chip can be with the probe of test substance specific reaction, the menses contact of filtered device filtering
Protein chip, antigen to be measured etc. is combined with the probe specificity with fluorescent marker in protein chip, under the irradiation of exciting light
Send fluorescence.One or more in the test substance such as C12 tumor markerses, HPV antigens.Implement as preferable
Mode, the protein chip are transparent material, and fluorescence is sent in protein chip and passes through chip bottom.Or preferably, it is described
Protein chip be permeability filter membrane, the one side that menses may penetrate into close to photovoltaic converter reacted.
Exciting light sources send exciting light, and protein chip is reflexed to by dichroic filter, special in elicitor protein chip
The mark substance that the opposite sex combines sends fluorescence, and the fluorescence sent transmitted through dichroic filter, is collected to photoelectricity by lens and turned again
Change device, photovoltaic converter converts optical signal into electric signal, amplifies through signal amplifier, then is sent out by wireless signal transmission
Send to external electronic device.
The wireless signal transmission is selected from WiFi chip, Bluetooth chip, RIFD chips or other wireless skills
Art communication chip.
The power supply unit is micro cell etc..Power supply unit is powered for sensor and wireless signal transmission, can be total to
With a power supply unit or it is used separately.Preferably, sensor and wireless signal transmission share one and supply Denso
Put, save space, realize the miniaturization of Intelligent sensing device.
The electronic equipment is smart mobile phone, computer, tablet etc..
The enriching apparatus is located in the absorber of tapon.Enriching apparatus is upper end opening, and lower end closed is led
Pipe.Opening is located at tapon insertion end, and there is a mobilizable baffle in opening lower section, when menses flow into enriching apparatus, baffle
Opened under the action of menses gravity, when no menses flow into, then the baffle is in closed state.The lower end of enriching apparatus also has one
Enriching apparatus takes out line, the extraction for enriching apparatus.Histocyte, the blood that enriching apparatus can be enriched with feminine menstrual blood are thin
Born of the same parents, secretion etc..After the completion of enrichment, enriching apparatus is split, is further analyzed by third party's pertinent instruments and technological means
The physiological and biochemical index in women menses is confirmed, so as to detect or confirm the generation of disease.
The beneficial effect that the present invention obtains：
1) Weight detector in tapon first of the invention, realizes the real-time test of menses.
2) collection sampling and diagnosis one, are not required to patient and appear in clinic, patient will not be made to feel to humiliate, non-invasi and invade
Entering property.
3) in situ, real-time diagnosis：The amenities of the present invention integrates sample collection, detection, data mart modeling processing, only
It need to be used in intermenstrual period, you can detection data are received by electronic equipment.
4) many indexes can be detected at the same time：A) can be by setting different sensors to realize different physiological and biochemical indexs
Detection, such as menstrual blood loss, pH, microorganism；B), can be by adjusting for the menses detection device containing Protein sensor
Ligand on substrate, realizes different medicals diagnosis on disease, as five index of hepatitis b detects at the same time, tumor-marker analyte detection, trace antigen
Antibody test, the identification of SARS antibody drugs, viral diagnosis and acute myocardial infarction diagnostic markers analyte detection etc..
5) Multiple detection ensures accuracy：The tapon of the present invention can also be equipped with detachable enriching apparatus, can will be through
After the enrichment such as cell and body fluid in blood, further pass through third party's pertinent instruments and technological means (such as quantitative PCR and ELISA
Deng), furanone items physiological and biochemical index, improves disease forecasting and the accuracy diagnosed.
Brief description of the drawings
1. Fig. 1 is a kind of schematic diagram of tapon containing test strips in the embodiment of the present invention one
2. Fig. 2 is a kind of schematic diagram of tapon containing Intelligent sensing device in the embodiment of the present invention two
3. Fig. 3 is the schematic diagram of the Intelligent sensing device in the embodiment of the present invention two
4. Fig. 4 is the schematic diagram of the Protein sensor in the embodiment of the present invention two
5. Fig. 5 is a kind of schematic diagram of tapon containing enriching apparatus in the embodiment of the present invention three
6. Fig. 6 is a kind of signal of tapon containing enriching apparatus and Intelligent sensing device in the embodiment of the present invention four
Figure
7. Fig. 7 is a kind of schematic diagram of the principle of chemiluminescence detection
8. Fig. 8 is a kind of schematic diagram of the testing principle of fluorescent marker
Illustrate：
1. absorber
11. tapon insertion end, 12. tapon withdrawal ends
2. tapon takes out line
3. test strips
31 injection ports, 32. detection zones, 33. test strips take out line
4. Intelligent sensing device
41 filtration apparatuses, 42. sensors, 43. wireless signal transmissions, 44. power supply units
421. protein chips, 422. exciting light sources, 423. dichroic filters, 424. lens, 425 photovoltaic converters,
426. signal amplifier
5. enriching apparatus
51 openings, 52 baffles, 53 enriching apparatus take out line
6. electronic equipment
Embodiment
Technical scheme is further illustrated below by way of specific embodiment, and specific embodiment is not represented to this hair
The limitation of bright protection domain.Other people according to the present invention theory made some it is nonessential modification and adjustment still fall within this hair
Bright protection domain.
A kind of tapon containing test strips of embodiment 1
Tapon as shown in Figure 1, takes out line 2, absorber 1 is internally provided with test paper containing absorber 1 and tapon
Bar 3 (in this example, the test strips 3 are HIV test strips).One injection port 31 is arranged at the top of test strips 3, and injection port 31 is located at
The insertion end 11 of tapon, has a detection zone 32 among test strips 3, detection zone 32 can show testing result.Whole test strips 3
Except injection port 31 and test strips take out line 33, the structure that test strips 3 are located in absorber 1 is in sealing state, to prevent absorber 1
In menses influence detection reaction.3 bottom of test strips has a stretching test strips to take out line 33, the extraction for test strips 3.Use
When, menses contact the injection port of test strips 3, through capillary action, are reacted into detection zone 33 and show result.Extract cotton wool out
After bar, then take out line 33 by test strips and extract test strips 3 out, you can observation testing result.Cotton wool of the invention containing test strips
The detection that bar carries out HIV limits from place, and non-invasi, easy to find disease in time, has important application value.Except
HIV test strips, tapon of the invention can also load other test strips of the prior art, or the test paper oneself made
Bar.
A kind of tapon containing Intelligent sensing device of embodiment 2
Tapon as shown in Figure 2, takes out line 2, absorber 1 is internally provided with intelligence containing absorber 1 and tapon
Sensing device 4, the Intelligent sensing device 4 are connected by wireless signal with electronic equipment 6.
Intelligent sensing device 4 as shown in Figure 3, upper end are provided with filtration apparatus 41 (being in the present embodiment filter membrane), pass
Sensor 42, wireless signal transmission 43 and power supply unit 44.The sensor 42 can be in the prior art biology, physics
With the one or more in chemical sensor, for example, for enzyme sensor of the prior art, immunosensor, bacterium sensor
One or more in.The sensor 42 is connected by circuit with wireless signal transmission 43.Wireless signal transmission
Electric signal is analyzed, obtained in menses by electromagnetic radiation to electronic equipment 6, electronic equipment 6 by device 43 by software processing
Physiological and biochemical index.The electronic equipment 6 is (in the present embodiment, the electronic equipments such as mobile phone, computer, tablet
, can real time inspection physical condition online for mobile phone).The power supply unit 44 passes through circuit and sensor 42 and wireless communication
Number transmitting device 43 is connected.The power supply unit 44 is micro cell.
Further, a sensor in the present embodiment is the Protein sensor shown in Fig. 4.The albumen
Matter sensor contain protein chip 421, exciting light sources 422, dichroic filter 423, lens 424, photovoltaic converter 425
And signal amplifier 426.
The protein chip 421 is located at the lower section of filtration apparatus 41.Being fixed with protein chip can be special with test substance
Property reaction probe, the menses contactin chip 421 that filtered device 41 filters, antigen to be measured etc. and band in protein chip
The probe specificity of fluorescent marker combines, and fluorescence is sent under the irradiation of exciting light.The test substance such as C12 tumor-markers
One or more in thing, HPV antigens etc..The protein chip 421 is transparent material, and exciting light and fluorescence can pass through core
Piece bottom.
Dichroic filter 423 is located at the lower section of protein chip 421, and same level horizontal plane is in exciting light sources 422.
Exciting light sources 422 send exciting light, 423 reflected excitation light of dichroic filter to protein chip 421, excitation specific binding
Mark substance send fluorescence, the fluorescence sent is again transmitted through dichroic filter.In the present embodiment, the excitation light
Source is purple LED.
The lens 444 are located at the lower section of dichroic filter 423, will transmit through the fluorescence aggregation of dichroic filter 423
To photovoltaic converter 425 and signal amplifier 426.The photovoltaic converter 425 and signal amplifier 426 are passed with wireless signal
Defeated device 43 is connected by circuit.Enlarged electric signal is sent to electronic equipment 6, electronics by wireless signal transmission 43
It is furnished with corresponding software in equipment, is analyzed by processing of the software to gathered data, final realization is online, understands tester in real time
Health status.
The tapon containing Intelligent sensing device of the invention, by tumor markers especially gynecological tumor marker,
HPV antigens etc. detect, can with early warning or auxiliary diagnosis, the analysis course of disease, guiding treatment, monitoring recurrence or transfer, judge it is pre-
Afterwards etc..
A kind of tapon containing enriching apparatus of embodiment 3
Tapon as shown in Figure 5, takes out line 2, absorber 1 is internally provided with enrichment containing absorber 1 and tapon
There are an opening 51, the lower section of opening 51 of enriching apparatus 5, equipped with a movable baffle in device 5,5 lower end closed of enriching apparatus, upper end
52, when menses, which flow into entrance 51, flows into enriching apparatus 5, baffle 52 is opened under the action of menses gravity, when no menses flow into,
Then the baffle 52 is in closed state.The lower end of enriching apparatus 5 also has an enriching apparatus to take out line 53, facilitates the pumping of enriching apparatus 5
Go out.
Enriching apparatus 5 can be enriched with histocyte in feminine menstrual blood, blood cell, secretion etc.., will after the completion of enrichment
Enriching apparatus 5 is split, and the physiology for further detecting or confirming in women menses by third party's pertinent instruments and technological means is given birth to
Change index, so as to detect the generation of disease.
A kind of tapon containing enriching apparatus and Intelligent sensing device of embodiment 4
Tapon as shown in Figure 6 is internally provided with Intelligent sensing device 4 and enriching apparatus 5.
Intelligent sensing device repeats embodiment 2, and enriching apparatus repeats embodiment 3.
Claims (10)
1. a kind of tapon, takes out line, it is characterised in that the tapon is loaded with examining comprising absorber, tapon
Survey device and/or enriching apparatus.
2. tapon as claimed in claim 1, it is characterised in that the detection device is physical detection device, chemistry
One or more in detection device, biological monitor；
Or alternatively, the detection device is test strips, one kind in Intelligent sensing device or its combination.
3. tapon as claimed in claim 1, it is characterised in that the test strips are located in absorber, the examination
Paper slip top is injection port, and injection port is located at tapon insertion end；Contain test strips pumping line, examination in the test strips bottom
Paper slip takes out line and is located at tapon withdrawal end；The test strips also contain a detection zone；
Preferably, the test paper be Dry-type biochemical test strip, it is five test paper of blood, whole blood urea bio-sensing test paper, micro-
One or more in secondary element measure test paper, HIV test paper.
4. tapon as claimed in claim 1, it is characterised in that the Intelligent sensing device is located at tapon absorption
In body.
5. tapon as claimed in claim 4, it is characterised in that the Intelligent sensing device contains sensor, wireless
Signal transmitting apparatus and power supply unit；
Preferably, a filtration apparatus contain above the Intelligent sensing device, is sensor below filtration apparatus, sensor with
Wireless signal transmission is connected by circuit.
6. tapon as claimed in claim 5, it is characterised in that the sensor is MEMS sensor；
Preferably, the sensor is the one or more in physical sensors, chemical sensor and biology sensor；
The physical sensors are humidity sensor, temperature sensor, heat-sensitive sensor, weight sensor and volume sensor
In one or more；
The chemical sensor is ion sensitive sensor, gas sensor, pH sensors；
The biology sensor for microbiological sensor, immunosensor, tissus sensor, cell sensor, enzyme sensor,
One or more in nucleic acid sensor, Protein sensor.
7. tapon as claimed in claim 5, it is characterised in that
The filtration apparatus is filter membrane, filter, filter screen, sieving gel or Filter column；Preferably, it is filter membrane；
The wireless signal transmission is WiFi chip, Bluetooth chip or RIFD chips；
The power supply unit is micro cell.
8. tapon as claimed in claim 6, it is characterised in that the sensor is Protein sensor, described
Protein sensor contains protein chip, exciting light sources, dichroic filter, lens, photovoltaic converter and signal amplifier；
The protein chip is located at the lower section of filtration apparatus；Protein chip is transparent material；The protein chip, dichroic
Optical filter, lens and photovoltaic converter are in same straight line successively；Photovoltaic converter is connected with signal amplifier by circuit.
9. tapon as claimed in claim 1, it is characterised in that the enriching apparatus is located at absorbent tampon body
In；There is an opening in the enriching apparatus upper end, and there is a baffle in opening lower section；There is enriching apparatus pumping in the lower end of enriching apparatus
Line.
10. tapon as described in claim 1-9 any one is for detecting the histocyte in women menses/thin
The detection sliver of bacterium/fungi/virus/tumor markers/HPV antigens/enzyme/trace element/pH/ hormones/menstrual blood loss.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610956358.0A CN107981870A (en) | 2016-10-27 | 2016-10-27 | A kind of tapon |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610956358.0A CN107981870A (en) | 2016-10-27 | 2016-10-27 | A kind of tapon |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107981870A true CN107981870A (en) | 2018-05-04 |
Family
ID=62028507
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610956358.0A Pending CN107981870A (en) | 2016-10-27 | 2016-10-27 | A kind of tapon |
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| Country | Link |
|---|---|
| CN (1) | CN107981870A (en) |
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| CN110090112A (en) * | 2019-05-07 | 2019-08-06 | 天空生活科技(深圳)有限公司 | A kind of cotton wool reacting health index by menses |
| WO2024152423A1 (en) * | 2023-01-18 | 2024-07-25 | 珠海舒桐医疗科技有限公司 | Portable device for collecting menstrual blood sample and hpv rapid detection system |
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