CN108057097A - A kind of Chinese herb drugs prescription for treating proteinuria of renal disease and preparation and preparation method thereof - Google Patents

A kind of Chinese herb drugs prescription for treating proteinuria of renal disease and preparation and preparation method thereof Download PDF

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CN108057097A
CN108057097A CN201810148462.6A CN201810148462A CN108057097A CN 108057097 A CN108057097 A CN 108057097A CN 201810148462 A CN201810148462 A CN 201810148462A CN 108057097 A CN108057097 A CN 108057097A
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radix
prescription
renal disease
rhizoma
proteinuria
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朱团结
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
    • A61K36/344—Codonopsis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236—Ligusticum (licorice-root)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/27—Asclepiadaceae (Milkweed family), e.g. hoya
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284—Atractylodes
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/286—Carthamus (distaff thistle)
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/35—Caprifoliaceae (Honeysuckle family)
    • A61K36/355—Lonicera (honeysuckle)
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/46—Eucommiaceae (Eucommia family), e.g. hardy rubber tree
    • A—HUMAN NECESSITIES
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537—Salvia (sage)
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/90—Smilacaceae (Catbrier family), e.g. greenbrier or sarsaparilla
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps

Abstract

The invention discloses a kind of Chinese herb drugs prescription for treating proteinuria of renal disease and preparations and preparation method thereof.The present invention provides a kind of Chinese herb drugs prescription, which is " Radix Codonopsis, raw Radix Astragali, Rhizoma Atractylodis Macrocephalae, smilax, paniculate swallowwort, Cortex Eucommiae, Radix Angelicae Sinensis, rhizoma imperatae, safflower, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, honeysuckle, licorice ".Decoction or electuary can be made in the prescription." medication in 9 months+observation is treated " method is used to take the Chinese medicine preparation of the present invention, has apparent therapeutic effect to reducing Urine proteins.

Description

A kind of Chinese herb drugs prescription for treating proteinuria of renal disease and preparation and preparation method thereof
Technical field
The invention belongs to the Chinese herbal medicines of field of Chinese herbal, more particularly to treatment of kidney disease.
Background technology
Kidney is the main device pipe in personal Shangdi, its effect directly affects health, and the treatment of kidney trouble is always A problem, although there are many method for controlling kidney, drug is many, and effect is unsatisfactory.Wherein glomerulonephritis, invisible kidney Inflammation, pyelonephritis, Henoch Schonlein purpura nephritis, lupus erythematosus nephritis, gout kidney, iga nephrosis, nephrotic syndrome, membranous nephropathy, kidney Sick syndrome, diabetic nephropathy, hypertensive nephropathy, polycystic kindey, etc., when the morbidity delay of these nephrosis is refractory, the time is more than Three months, there is exception in patient urine and relevant physiochemical indice, and Renal Paphology, iconography note abnormalities and all can be collectively referred to as " chronic kidney disease ".Due to the filtration of glomerular filtration membrane and the reabsorption of renal tubule, protein is (more in healthy human urine Refer to molecular weight smaller protein) content seldom (be less than 150mg per daily output), during protein qualitative examination, be negative Reaction.When protein content increases in urine, common routine urianlysis can be measured, and claim albuminuria.If urine protein content >= 3.5g/24h, then referred to as High-grade Proteinuria, be nephrosis important clinical diagnosis index.Chronic kidney disease such as fails timely and effective rescue It controls, causes sb.'s illness took a turn for the worse to be in progress, then with protracted course, Patients with Chronic Renal Disease will develop into chronic renal insufficiency, kidney failure, Ultimately form uremia.How chronic kidney disease is treated, and treatment albumen urine is the current problem for being badly in need of solving, especially with medium-height grass Medicine is treated.
Nineteen eighty-two Viberti etc. has found diabetic's urine total protein in normal range (NR), and urinary albumin excretion increases The phenomenon that, it first proposed the concept of microdose urine protein (ALB).Albumin is one of important plasma proteins, normal In the case of, the molecular weight of albumin is big, it is impossible to glomerular basement membrane is crossed, it is therefore, only very low containing concentration in Healthy People urine Albumin, specific to every liter of urinary albumin be no more than 20mg, so being otherwise known as " microdose urine protein inspection ".During disease, Glomerular basement membrane, which is damaged, causes permeability to change, any lesion that glomerular basement membrane permeability can be caused to increase, The discharge of albumin can be caused.This when, albumin can enter in urine, and urine albumin concentration may occur in which lasting liter It is high.
Microdose urine protein measures reflection early nephropathy, injury of kidney situation.It is nephrosis in microdose urine protein stage early stage The early signal and omen of generation, kidney damage is in still reversible period at this time, as can treatment in time, can terminate or inverse Turn the development process of nephrosis.Microdose urine protein detection can be as systemic or local inflammation reaction renal function index.
Twenty-four-hour urine protein quantification is also known as twenty-four-hour urine protein excretion rate, is whole urines by collection 24 when small, Measure the content of protein therein, so calculate 24 it is small when in Tot Prot, therefore can reflect patient exactly The situation of protein loss among one day.There are the protein of small-molecular-weight in the glomerular filtrate of normal person, by near bent The overwhelming majority is again by reabsorption during tubule.When protein is more than normal range (NR) in urine, it is known as albuminuria.Albuminuria is kidney trouble Common manifestation, some systemic diseases also may occur in which albuminuria.
The reduction of urine micro protein or twenty-four-hour urine albumen is the important indicator of chronic kidney disease therapeutic effect.
Although treat nephrosis Urine proteins method it is very much, drug is many, take effect it is unsatisfactory, Chinese medicine be China one greatly Tradition, it is abstruse boundless, it is of extensive knowledge and profound scholarship, it may therefrom excavate the satisfactory good recipe for specially controlling nephrosis.
The content of the invention
The object of the present invention is to provide a kind of Chinese herb drugs prescription for treating proteinuria of renal disease and preparations and preparation method thereof, make With rational herbal prescription preparation, the Chinese herbal and crude drugs preparations prepared using prescription of the present invention can reduce urine micro protein or 24 small When Urine proteins index, treatment nephrosis it is with obvious effects.
A kind of Chinese herb drugs prescription for treating proteinuria of renal disease is provided according to an aspect of the present invention, and prescription includes：Radix Codonopsis, Raw Radix Astragali, Rhizoma Atractylodis Macrocephalae, smilax, rhizoma imperatae, safflower, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, honeysuckle, Cortex Eucommiae, Radix Angelicae Sinensis, paniculate swallowwort, licorice.
Provide a kind of Chinese herb drugs prescription for treating proteinuria of renal disease according to another aspect of the present invention, component in prescription Content be：Radix Codonopsis 10.5%~12.5%, raw Radix Astragali 10.5%~12.5%, Rhizoma Atractylodis Macrocephalae 6.0%~7.1%, smilax 6.0% ~7.1%, licorice 3.5%~4.5%, rhizoma imperatae 10.5%~12.5%, safflower 4.0%~4. 5%, Rhizoma Chuanxiong 4.5%~ 6.5%, Radix Salviae Miltiorrhizae 6.0%~6.5%, honeysuckle 10.5%~12.5%, Cortex Eucommiae 6.0%~7.2%, Radix Angelicae Sinensis 10.0%~ 11.0%, paniculate swallowwort 4.0%~4.5%.
Provide a kind of Chinese herb drugs prescription for treating proteinuria of renal disease according to another aspect of the present invention, component in prescription Content be：Radix Codonopsis 11.40%, raw Radix Astragali 11.40,6.59% smilax 6.59% of Rhizoma Atractylodis Macrocephalae, licorice 3.95%, rhizoma imperatae 11.40%th, safflower 4.18%, Rhizoma Chuanxiong 5.62%, Radix Salviae Miltiorrhizae 6.24%, honeysuckle 11.40%, Cortex Eucommiae 6.58%, Radix Angelicae Sinensis 10.40%th, paniculate swallowwort 4.25%.
Provide a kind of Chinese herb drugs prescription for treating proteinuria of renal disease according to another aspect of the present invention, component in prescription Content be：Radix Codonopsis (15g~30g), raw Radix Astragali (15g~30g), Rhizoma Atractylodis Macrocephalae (10g~15g), smilax 10g~15g), life it is sweet Careless (6g~9g), rhizoma imperatae (15g~30g), safflower (6g~10g), Rhizoma Chuanxiong (9g~12g), Radix Salviae Miltiorrhizae (9g~15g), honeysuckle (15g~30g), Cortex Eucommiae (10g~15g), Radix Angelicae Sinensis (15g~25g), paniculate swallowwort (6g~10g).
A kind of optimizing prescriptions for the Chinese herbal medicine for treating proteinuria of renal disease are provided according to another aspect of the present invention, in prescription The content of a component is：Radix Codonopsis 20g, raw Radix Astragali 25g, Rhizoma Atractylodis Macrocephalae 12g, smilax 12g, licorice 8g, rhizoma imperatae 25g, safflower 8g, Rhizoma Chuanxiong 10g, Radix Salviae Miltiorrhizae 12g, honeysuckle 20g, Cortex Eucommiae 12g, Radix Angelicae Sinensis 20g, paniculate swallowwort 9g.
A kind of herbal decoction for treating proteinuria of renal disease is provided according to another aspect of the present invention, which is by upper State decoction prepared by several prescriptions.Decoction is conveniently taken, can packed bottle, directly take.
A kind of Chinese herbal medicine granule for the treatment of albumen urine is provided according to another aspect of the present invention, which is by above-mentioned Electuary prepared by several prescriptions.
A kind of preparation method for the herbal decoction for treating proteinuria of renal disease is provided according to another aspect of the present invention, is wrapped Include following steps：First by Radix Codonopsis, raw Radix Astragali, Rhizoma Atractylodis Macrocephalae, smilax, licorice, rhizoma imperatae, safflower, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, honeysuckle, Cortex Eucommiae, Radix Angelicae Sinensis, paniculate swallowwort are impregnated with 30 DEG C of pure water of water temperature, and 60 minutes used times, pure water consumption is 12 times of dose；Again Moderate heat boils, 110 DEG C~120 DEG C of the moderate heat water temperature；It is persistently cooked by slow fire after boiling, 115 DEG C of the slow boiling water temperature, the used time 120 minutes；The decoction of medicinal ingredients liquid obtained, thermal concentration obtain the herbal decoction of the treatment proteinuria of renal disease.
A kind of preparation method for the Chinese herbal medicine granule for treating proteinuria of renal disease is provided according to another aspect of the present invention, side Method includes the following steps：First by Radix Codonopsis, raw Radix Astragali, Rhizoma Atractylodis Macrocephalae, smilax, licorice, rhizoma imperatae, safflower, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, gold Honeysuckle flower, Cortex Eucommiae, Radix Angelicae Sinensis, paniculate swallowwort are mixed in above-mentioned prescription ratio active compound, crushed 40 mesh sieves, pure water impregnates 60 minutes, water 30 DEG C of temperature, 12 times of dry doses of water；Then boil medicine for the first time, normal pressure, 110~120 DEG C of temperature, 2 it is small when, for the first time filtering obtain Filtered fluid A；Its dregs of a decoction is boiled medicine for the second time, adds pure water, 8 times of dry doses of water, 110~120 DEG C of normal pressure, temperature, 2 is small When, second filtering obtain filtered fluid B；Filtered fluid A and filtered fluid B is removed into a raw material liquid huge sum of money into macroporous chelate resin is crossed Belong to, obtain refined Chinese traditional medicine water extract；By the concentration of refined Chinese traditional medicine water extract, dry, granulation.
Specific embodiment
The present invention is further illustrated below.
Embodiment 1
The prescription of the present invention is Radix Codonopsis, raw Radix Astragali, Rhizoma Atractylodis Macrocephalae, smilax, licorice, rhizoma imperatae, safflower, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, gold Honeysuckle flower, Cortex Eucommiae, Radix Angelicae Sinensis, paniculate swallowwort.The prescription can prepare decoction or electuary.
The preparation of 2 decoction of embodiment
First by Radix Codonopsis 20g, raw Radix Astragali 25g, Rhizoma Atractylodis Macrocephalae 12g, smilax 12g, licorice 8g, rhizoma imperatae 25g, safflower 8g, Medicinal herbs are (pure in pure water in 13 kinds of Rhizoma Chuanxiong 10g, Radix Salviae Miltiorrhizae 12g, honeysuckle 20g, Cortex Eucommiae 12g, Radix Angelicae Sinensis 20g, paniculate swallowwort 9g etc. Water, 30 DEG C of water temperature) in impregnate, 60 minutes used times；Then moderate heat (110 DEG C~120 DEG C of water temperature) boils, and continues slow boiling after boiling (115 DEG C of water temperature) decocts, 120 minutes used times；Obtain decoction of medicinal ingredients (thermal concentration liquid to 400ml), bag distribution packaging (150~200ml/ bags) It waits to take, refrigerator Cord blood (≤7 days), room temperature is taken.
The preparation of 3 electuary of embodiment
First will " Radix Codonopsis 11.40%, raw Radix Astragali 11.40,6.59% smilax 6.59% of Rhizoma Atractylodis Macrocephalae, licorice 3.95%, Rhizoma imperatae 11.40%, safflower 4.18%, Rhizoma Chuanxiong 5.62%, Radix Salviae Miltiorrhizae 6.24%, honeysuckle 11.40%, Cortex Eucommiae 6.58%, Radix Angelicae Sinensis 10.40%th, active compound mixes, pulverizes and sieves (40 mesh), impregnates 60 minutes (pure water, water temperatures 30 paniculate swallowwort 4.25% " in proportion DEG C), boil medicine for the first time (normal pressure, 110~120,110~120 DEG C of temperature, 2 it is small when), for the first time filtering (100 mesh) filtered Liquid A is boiled medicine its dregs of a decoction when small (115 DEG C of normal pressure, temperature, 2) for the second time, second of filtering (100 mesh) obtains filtered fluid B by filtered fluid A and filtered fluid B into " macroporous chelate resin " removal bulk pharmaceutical chemicals liquid heavy metal is crossed, obtains refined Chinese traditional medicine water extract；It will Refined Chinese traditional medicine water extract concentration, dry, granulation, obtain instant particles as Chinese medicine, it is for use that dose on the one is divided into two bags.
4 method of administration of embodiment
Above two Chinese medicine preparation instructions of taking：Full dose is treated 3 months, weight 40~75Kg patients, 1 bag (bag) Bid, Weight is more than 75 kg patients, 1 bag Tid.Therapeutic purpose urina sanguinis trace of albumin<200mg/L (or twenty-four-hour urine albumen<300mg ~500mg), it is changed to maintain medication (decrement treatment) 6 months afterwards, dose halves.After the maintaining treatment course for the treatment of, every 1~March Check Urine proteins, if Urine proteins increase above therapeutic purpose, can continue full dose treat 2 weeks, after be changed to decrement treatment maintenance.Full dose Invalid, stopping we's treatment in two weeks is taken in treatment.
Embodiment 5 takes case
1 decoction therapeutic effect of case
Patient female (Anhui Province's patient medical history is wrong), 63 years old, native place：Anhui Province's Lujiang County.
On June 28th, 2016 finds albuminuria in local hospital (Hefei City, Anhui Province Lujiang county people's hospital) physical examination.
2016.07.04 because of edema of pair of lower extremities, to go to a doctor in Provincial Hospital's Rheumatism Clinic, plan examines rheumatic heart disease, Check that feminine genders, the urina sanguinis inspections such as the rheumatism factor are shown：Microalbumin 717mg/L, Immunoglobulin IgG 53.0mg/L, iron egg is turned 1 microglobulin 21.4mg/L of white 34.6mg/L, α etc. increase.Give oral hydrochloride amino acid-glucose capsule and olsapozine Enteric coatel tablets take orally.
2016.07.09 Nephrology dept. of Provincial Hospital outpatient clinic, plan is examined as hypertensive nephropathy.Give Bailing capsule.Through Above-mentioned three medicine is taken orally to treat to 2016.09.08 check urina sanguinis：Microdose urine protein 1700mg/L.
2016.09.15 our traditional Chinese herbal decoction treatment, 9.28 check urina sanguinis are started, microdose urine protein 515mg/L is immunized Globulin IgG, transferrins, 1 microglobulins of α are reduced.Continue the treatment of this prescription medicine, 10.18 check microdose urine proteins 305mg/L, 11.03 check microdose urine protein 267mg/L, 11.17 check microdose urine protein 61.7mg/L, immune globulin White IgG, transferrins, 1 microglobulins of α are normal.
Case 2
Patient's Huang is forever, male, 29 years old；Work：House property medium sales manager；Native place：Xiuqian City of Jiangsu Province Siyang.
Diagnosis and treatment are passed through：Main suit physical examination finds high blood pressure, urine examination abnormal January.
Present illness history：
2016.10.19 in attached Suzhou Kowloon hospital of Medical College, Shanghai Communication Univ. (referred to as：Suzhou Kowloon hospital) check Urina sanguinis：Urine micro protein 3570mg/L, it is untreated.
2016.10.25 in Suzhou Kowloon Nephrology dept. of hospital outpatient clinic, further check and be diagnosed as：Chronic nephritis (albumen Urine, renal insufficiency), renal hypertension.It gives：Jinshuibao, profit times think of, medical charcoal (activated carbon), Valsartan, Lipitor etc. are controlled It treats.
206.11.08 medical Zhongshan Hospital Attached to Fudan Univ's (outpatient service number 0941938) check, twenty-four-hour urine：24 it is small when Urine proteins 811.5mg/L, twenty-four-hour urine Tot Prot 2272.2mg.On the basis of original drug therapy, add and use SHENFUKANG JIAONANG Treatment, by the about 1 wheat harvesting period state of an illness without being clearly better.
2016.12.19 day check urina sanguinis：Urine micro protein 3120mg/L disables the treatment nephrosis drug of all early periods, Start to receive the treatment of this traditional Chinese herbal decoction, medication 2 doses (14 pairs) enjoins its often to take within first 3 months 14 pairs of rests 5~7 days of being discontinued.
2017.01.08 check urina sanguinis (the attached First Academy of University Of Suzhou)：Urine proteins 496mg/L, twenty-four-hour urine albumen 1339mg/ L, albuminuria are clearly better.Phone contact learns that patient's medication is irregular through inquiry, is voluntarily discontinued to patient after 3 months afterwards Nearly 45 days.
2017.06.08 check urina sanguinis：Urine micro protein 356mg/L, patient feel well, voluntarily withdrawal observation.
2017.06.19 day checks urina sanguinis, Urine proteins：405mg/L, Urine proteins rise again.It is supervised to take medicine, prescription is identical, It is enjoined to adhere to medication 2 months, method of administration：It takes and stops within 5 days 2 days, suitable control diet and bad life habits (smoke, drink, enduring Night), receive 6 weeks Canonical managements.
2017.8.15 check urina sanguinis：Urine proteins 213mg/L (twenty-four-hour urine albumen<500mg has reached therapeutic purpose), And urinary immunoglobulin G, urine a1 microglobulins, creatinine are decreased obviously, it is enjoined often to take 3 pairs and is stopped 1 day, lasting medication half Year, but the patient still cannot voluntarily be discontinued by medication, in October, 2017, while start to smoke again, drink, stay up late, it drinks Half jin of white wine when wine is most.2017.12.18 check urina sanguinis：Urine micro protein 326ml/L (slightly gos up), still withdrawal observation at present In.
It summarizes
According to the summary of experience of the Chinese medicinal formulae clinical treatment albuminuria, method of administration is：" medication+observation in 9 months is controlled Treat ", i.e. preceding intensive treatment in 3 months (often taking 14 pairs, be discontinued 1 week), after rear 6 months maintaining treatments often take 7 pairs of drug withdrawals 1 week, 9 months 1 urina sanguinis (urine micro protein) of check in every 45 days, more than Urine proteins>500mg/ days, repeat maintenance dose medication.
The prescription of the present invention can effectively reduce nephrosis Urine proteins.
Following embodiments is in order to further illustrate some currently preferred embodiments of the present invention, and not all embodiments.This Field professional made on the premise of no progress creative work based on the other embodiment of the present invention, belong to this The rights protection scope of invention.

Claims (7)

1. a kind of Chinese herb drugs prescription for treating proteinuria of renal disease, the prescription include：It is Radix Codonopsis, raw Radix Astragali, Rhizoma Atractylodis Macrocephalae, smilax, white Lalang grass rhizome, safflower, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, honeysuckle, Cortex Eucommiae, Radix Angelicae Sinensis, paniculate swallowwort, licorice.
A kind of 2. Chinese herb drugs prescription for treating proteinuria of renal disease according to claims 1, which is characterized in that the prescription In the content of component be：Radix Codonopsis 10.5%~12.5%, raw Radix Astragali 10.5%~12.5%, Rhizoma Atractylodis Macrocephalae 6.0%~7.1%, soil Poria cocos 6.0%~7.1%, licorice 3.5%~4.5%, rhizoma imperatae 10.5%~12.5%, safflower 4.0%~4.5%, river Rhizome of chuanxiong 4.5%~6.5%, Radix Salviae Miltiorrhizae 6.0%~6.5%, honeysuckle 10.5%~12.5%, Cortex Eucommiae 6.0%~7.2%, Radix Angelicae Sinensis 10.0%~11.0%, paniculate swallowwort 4.0%~4.5%.
A kind of 3. Chinese herb drugs prescription for treating proteinuria of renal disease according to claims 2, which is characterized in that the prescription In the content of component be：Radix Codonopsis 11.40%, raw Radix Astragali 11.40,6.59% smilax 6.59% of Rhizoma Atractylodis Macrocephalae, licorice 3.95%, Rhizoma imperatae 11.40%, safflower 4.18%, Rhizoma Chuanxiong 5.62%, Radix Salviae Miltiorrhizae 6.24%, honeysuckle 11.40%, Cortex Eucommiae 6.58%, Radix Angelicae Sinensis 10.40%th, paniculate swallowwort 4.25%.
A kind of 4. herbal decoction for treating proteinuria of renal disease, which is characterized in that soup prepared by the prescription as described in claim 1 Agent.
5. a kind of Chinese herbal medicine granule for treating proteinuria of renal disease, which is characterized in that as described in claim 1 prepared by prescription rushes Agent.
6. the preparation method of the herbal decoction of proteinuria of renal disease is controlled described in claim 4, which is characterized in that the described method includes Following steps：First by Radix Codonopsis, raw Radix Astragali, Rhizoma Atractylodis Macrocephalae, smilax, licorice, rhizoma imperatae, safflower, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, honeysuckle, Du Secondary, Radix Angelicae Sinensis, paniculate swallowwort are impregnated with 30 DEG C of pure water of water temperature, and 60 minutes used times, pure water consumption is 12 times of dose；In again Fire boils, 110 DEG C~120 DEG C of the moderate heat water temperature；It is persistently cooked by slow fire after boiling, 115 DEG C of the slow boiling water temperature, the used time 120 Minute；The decoction of medicinal ingredients liquid obtained, thermal concentration obtain the herbal decoction of the treatment proteinuria of renal disease.
7. the preparation method of the Chinese herbal medicine granule of proteinuria of renal disease is treated described in claim 5, which is characterized in that the method bag Include following steps：First by Radix Codonopsis, raw Radix Astragali, Rhizoma Atractylodis Macrocephalae, smilax, licorice, rhizoma imperatae, safflower, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, honeysuckle, Active compound mixes, crushed 40 mesh sieves in proportion for Cortex Eucommiae, Radix Angelicae Sinensis, paniculate swallowwort, pure water impregnates 60 minutes, 30 DEG C of water temperature, water 12 Dry dose again；Then boil medicine for the first time, normal pressure, 110~120 DEG C of temperature, 2 it is small when, filtering obtains filtered fluid A for the first time；By its The dregs of a decoction are boiled medicine for the second time, add pure water, 8 times of dry doses of water, 110~120 DEG C of normal pressure, temperature, 2 it is small when, second of mistake Filter obtains filtered fluid B；By filtered fluid A and filtered fluid B into macroporous chelate resin removal bulk pharmaceutical chemicals liquid heavy metal is crossed, refined Chinese medicine is obtained Aqueous extracts；By the concentration of refined Chinese traditional medicine water extract, dry, granulation.
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114917310A (en) * 2022-04-20 2022-08-19 首都医科大学附属北京中医医院 Traditional Chinese medicine for treating chronic kidney disease in 3-5 stages and preparation method thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101269139A (en) * 2008-04-15 2008-09-24 钱桐荪 Medicine for treating nephritis type haematuria
CN103127406A (en) * 2013-02-05 2013-06-05 刘景城 Composite kidney-benefiting medicine
CN105362521A (en) * 2015-11-29 2016-03-02 刘景城 Spleen-invigorating kidney-tonifying composition

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101269139A (en) * 2008-04-15 2008-09-24 钱桐荪 Medicine for treating nephritis type haematuria
CN103127406A (en) * 2013-02-05 2013-06-05 刘景城 Composite kidney-benefiting medicine
CN105362521A (en) * 2015-11-29 2016-03-02 刘景城 Spleen-invigorating kidney-tonifying composition

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
高祥福: "健脾补肾活血法治疗蛋白尿68例临床体会", 《浙江中医杂志》 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114917310A (en) * 2022-04-20 2022-08-19 首都医科大学附属北京中医医院 Traditional Chinese medicine for treating chronic kidney disease in 3-5 stages and preparation method thereof
CN114917310B (en) * 2022-04-20 2023-08-04 首都医科大学附属北京中医医院 Traditional Chinese medicine for treating 3-5 stages of chronic kidney disease and preparation method thereof

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Application publication date: 20180522