CN108034994B - Electrostatic spinning device and method for preparing intervertebral disc fibrous ring - Google Patents
Electrostatic spinning device and method for preparing intervertebral disc fibrous ring Download PDFInfo
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- CN108034994B CN108034994B CN201711390291.XA CN201711390291A CN108034994B CN 108034994 B CN108034994 B CN 108034994B CN 201711390291 A CN201711390291 A CN 201711390291A CN 108034994 B CN108034994 B CN 108034994B
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- transmission shaft
- winding roller
- receiving
- winding
- intervertebral disc
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- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
- D01D5/00—Formation of filaments, threads, or the like
- D01D5/0007—Electro-spinning
- D01D5/0061—Electro-spinning characterised by the electro-spinning apparatus
- D01D5/0076—Electro-spinning characterised by the electro-spinning apparatus characterised by the collecting device, e.g. drum, wheel, endless belt, plate or grid
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- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
- D01D1/00—Treatment of filament-forming or like material
- D01D1/06—Feeding liquid to the spinning head
Abstract
The invention discloses an electrostatic spinning device for preparing intervertebral disc fibrous rings, which comprises a liquid supply spinning device, a receiving device and a winding and looping device, wherein the liquid supply spinning device is connected with the receiving device through a liquid supply pipe; the liquid supply spinning device comprises an injector, the injector is provided with a needle head, and the needle head is connected with the positive pole of the direct-current high-voltage generator; the receiving device is used for receiving and lapping the oriented nano fibers; the winding and looping device comprises a winding roller for winding the nanofiber lapped on the receiving device into a fiber loop. The invention also discloses a method for preparing the intervertebral disc annulus fibrosus by adopting the above-mentioned device. The device has simple structure and easy operation, can form the required fiber ring layered structure at one time, and does not need secondary processing; controlling the parallel arrangement direction of fibers of each layer of the fiber ring by the circumferential rotation and horizontal movement of the winding roller, wherein the arrangement directions of the fibers of two adjacent layers are reversely crossed along the left side and the right side of the axial direction; the prepared nanofiber ring has good hierarchical appearance, the included angle of each layer of fiber is basically consistent, and the included angle of the arrangement direction and the axial direction is about 60 degrees.
Description
Technical Field
The invention belongs to the technical field of electrostatic spinning, relates to an electrostatic spinning device for preparing intervertebral disc fibrous rings, and further relates to a method for preparing the intervertebral disc fibrous rings by adopting the device.
Background
The intervertebral disc is a sealed body which is positioned between two vertebral bodies of a vertebral column of a human body and consists of a cartilage plate, a fibrous ring and nucleus pulposus. The fiber ring is positioned around the nucleus pulposus and comprises 15-25 annular collagen fiber plate layers which are closely arranged, fibers in each layer are basically parallel, and the arrangement direction of the fibers and the longitudinal axis form an included angle of about 60 degrees in the circumferential direction of the intervertebral disc. The fiber arrangement direction between adjacent plate layers is reversely alternated along the left side and the right side of the longitudinal axis.
The damage of the annulus fibrosus can cause the phenomena of nucleus pulposus protrusion, outflow and the like, cause the degeneration of intervertebral discs, cause the pain of the waist and the back, and influence the life quality of people. Thus, the key to treating disease is repair of the annulus fibrosus, but its self-repair capacity is very limited. According to the prior art, repair is only possible with thin fibrous tissue that is biomechanically poor. The current major treatments include the technique of annulus fibrosis suturing and removal of the damaged annulus, but none of them compensate for the lost tissue of the annulus and reverse the compromised biomechanical properties. With the development of medicine, the tissue engineering intervertebral disc can completely regenerate and repair the annulus fibrosus from the structural and biological functions, and a new thought is provided for treating pains. The tissue engineering scaffold intervertebral disc mainly comprises 3 parts of an annulus fibrosus, a nucleus pulposus and cartilage end plates. The fibrous ring has the functions of limiting nucleus pulposus and bearing the torsional load of the vertebral column, and is the key point for constructing the intervertebral disc of the tissue engineering scaffold. Compared with other methods for preparing the tissue engineering scaffold, the nanofiber prepared by the electrostatic spinning technology has the characteristics of large specific surface area, high porosity and the like, can better simulate extracellular matrix, and is a better method for preparing the tissue engineering scaffold at present.
Disclosure of Invention
The invention aims to provide an electrostatic spinning device for preparing an intervertebral disc fibrous ring, which is used for preparing the intervertebral disc fibrous ring with better bionic performance.
It is another object of the present invention to provide a method for preparing an annulus fibrosus of an intervertebral disc using the above-described device.
The invention adopts the technical scheme that the electrostatic spinning device for preparing the intervertebral disc annulus fibrosus comprises a liquid supply spinning device, a receiving device and a winding and looping device;
the liquid supply spinning device comprises an injector, the injector is provided with a needle head, and the needle head is connected with the positive pole of the direct current high voltage generator;
the receiving device is used for receiving and lapping the nano fibers;
the winding and looping device comprises a winding roller for winding the nanofiber lapped on the receiving device into a fiber loop.
The present invention is also characterized in that,
the receiving device is composed of two parallel vertically fixed receiving plates, the nanofibers are lapped between the two receiving plates, and the winding roller is located between the two receiving plates.
The winding roller is arranged on the transmission shaft and performs circumferential autorotation motion and horizontal motion following the transmission shaft.
The winding and looping device further comprises a transmission shaft support, two ends of the transmission shaft are respectively connected with the left support and the right support of the transmission shaft support, the transmission shaft support is connected with the mandrel motor, and the mandrel motor drives the transmission shaft support to move horizontally.
The transmission shaft is connected with the variable frequency motor, and the variable frequency motor drives the transmission shaft to rotate, so that the winding roller is driven to rotate in the circumferential direction.
The invention adopts another technical scheme that the method for preparing the intervertebral disc fiber ring adopts an electrostatic spinning device for preparing the intervertebral disc fiber ring, which comprises a liquid supply spinning device, a receiving device and a winding and looping device;
the liquid supply spinning device comprises an injector, the injector is provided with a needle head, and the needle head is connected with the positive pole of the direct current high voltage generator;
the receiving devices are two parallel vertically fixed receiving plates;
the winding and looping device comprises a winding roller, the winding roller is positioned between the two receiving plates and is used for winding the nano fibers lapped on the receiving devices into fiber loops;
the winding roller is arranged on the transmission shaft and performs circumferential self-rotation motion and horizontal motion following the transmission shaft;
the winding and looping device also comprises a transmission shaft bracket, two ends of the transmission shaft are respectively connected with the left bracket and the right bracket of the transmission shaft bracket, the transmission shaft bracket is connected with a mandrel motor, and the mandrel motor drives the transmission shaft bracket to move horizontally;
the transmission shaft is connected with the variable frequency motor, and the variable frequency motor drives the transmission shaft to rotate so as to drive the winding roller to rotate in the circumferential direction;
the method is implemented by the following steps:
injecting the spinning solution into an injector, and adjusting the distance between a needle head and a receiving plate under the environmental conditions of room temperature and 35-60% of relative humidity; and starting the direct-current high-voltage generator, adjusting the applied voltage, and after the liquid drops and the jet flow are stable, starting the variable-frequency motor and the mandrel motor to drive the winding roller to horizontally reciprocate at a certain speed and simultaneously circumferentially rotate, and finally obtaining fiber rings on the winding roller.
The present invention is also characterized in that,
the vertical distance between the needle head and the two parallel receiving plates is 100 mm-300 mm.
The applied voltage is 10kV to 30 kV.
The circumferential rotating speed of the winding roller is 200 r/min-500 r/min.
The horizontal moving speed of the winding roller is 6 m/min-10 m/min.
The beneficial effect of the invention is that,
1. the device has simple structure and easy operation, can form the required fiber ring layered structure at one time, and does not need secondary processing;
2. the device controls the parallel arrangement direction of fibers of each layer of a fiber ring through the circumferential rotation and the horizontal movement of the winding roller, and the arrangement directions of the fibers of two adjacent layers are reversely crossed along the left side and the right side of the axial direction;
3. the nano fiber ring prepared by the device has good level appearance, the included angle of each layer of fiber is basically consistent, and the included angle of the arrangement direction and the axial direction is about 60 degrees.
Drawings
FIG. 1 is a schematic structural diagram of an electrospinning device for preparing an intervertebral disc annulus according to the present invention;
FIG. 2 is a schematic cross-sectional view of an annulus fibrosus of an intervertebral disc prepared by a method of the present invention.
In the figure, 1, an injector, 2, a needle, 3, a direct current high voltage generator, 4, a transmission shaft, 5, a receiving plate, 6, a winding roller, 7, a variable frequency motor, 8, a transmission shaft bracket, 9, a receiving plate bracket, 10, a base, 11, a mandrel motor and 12, a grounding wire.
Detailed Description
The present invention will be described in detail below with reference to the accompanying drawings and specific embodiments.
The invention relates to an electrostatic spinning device for preparing intervertebral disc fibrous rings, which has a structure shown in figure 1 and comprises a liquid supply spinning device, a receiving device and a winding and looping device;
the liquid supply spinning device comprises an injector 1, the injector 1 is provided with a needle head 2, and the needle head 2 is connected with the anode of a direct current high voltage generator 3;
the receiving device is used for receiving and lapping the nano fibers; the receiving device comprises two parallel vertically fixed receiving plates 5, and the nano fibers are lapped between the two receiving plates 5; the two receiving plates 5 are fixed on the receiving plate bracket 9. The receiving plate 5 is connected to the ground line 12.
The winding and looping device comprises a winding roller 6, wherein the winding roller 6 is positioned between two receiving plates 5 and is used for winding the nano fibers overlapped on the receiving devices into fiber loops. The winding roller 6 is made of polytetrafluoroethylene.
The winding roller 6 is mounted on the transmission shaft 4 and performs circumferential rotation movement and horizontal movement following the transmission shaft 4.
The winding and looping device further comprises a transmission shaft support 8, two ends of the transmission shaft 4 are respectively connected with a left support and a right support of the transmission shaft support 8, the transmission shaft support 8 is connected with a mandrel motor 11, and the mandrel motor 11 drives the transmission shaft support 8 to move horizontally. The receiving means is located between the left and right brackets of the drive shaft bracket 8.
The transmission shaft 4 is connected with a variable frequency motor 7, and the variable frequency motor 7 drives the transmission shaft 4 to rotate, so that the winding roller 6 is driven to rotate in the circumferential direction.
The transmission shaft support 8 and the receiving plate support 9 are installed on a base 10, a sliding rail is arranged on the base 10, and the right support of the transmission shaft support 8 moves back and forth along the sliding rail.
In the spinning process, the oriented parallel nano fibers can be formed by using the parallel receiving plates 5; the variable frequency motor 7 drives the winding roller 6 in the middle to rotate in the circumferential direction by driving the transmission shaft 4 to rotate so as to form a fiber ring; the mandrel motor 11 drives the right bracket of the transmission shaft bracket 8 to move, and further drives the transmission shaft 4 fixed on the right bracket to horizontally move, so as to control the arrangement angle of fibers. The fiber structure with all layers of surfaces basically arranged in parallel can be obtained through the device, the arrangement direction and the axial direction form an included angle of about 60 degrees, and the arrangement directions of the fibers of two adjacent layers of surfaces are reversely crossed along the left side and the right side of the axial direction.
The method for preparing the intervertebral disc annulus fibrosus by using the electrostatic spinning device is implemented by the following steps:
injecting the spinning solution into an injector 1 of the device, under the environmental conditions of room temperature and relative humidity of 35-60%, adjusting the vertical distance between a needle head 2 and two parallel receiving plates 5 to be 100-300 mm, starting a variable frequency motor 7 and a mandrel motor 11, after a winding roller 6 and a transmission shaft bracket 8 run stably, starting a direct current high voltage generator 3, adjusting the applied voltage to be 10-30 kV, the rotating speed of the winding roller 6 to be 200-500 r/min, the horizontal moving speed of a transmission shaft 4 to be 6-10 m/min (namely the horizontal moving speed of the winding roller 6), after liquid drops and jet flow are stable, lapping the nano fibers on the two parallel receiving plates 5 under the action of electric field force, horizontally moving the winding roller 6 between the two plates at a constant speed through the control of the mandrel motor 11, dragging the nano fibers contacted with the winding roller to a certain angle, the collected fibers are arranged in parallel with the winding roller at a certain angle, and continuously run in opposite directions after the transmission shaft bracket 8 runs for a certain distance, so that fiber rings which are in a left-right alternating shape along the longitudinal axis in the arrangement direction of the fibers of the adjacent layers of the winding roller 6 are obtained.
The section of the fiber ring prepared by the invention is shown in figure 2, the fibers in each layer of the fiber ring are basically parallel, and the arrangement direction and the longitudinal axis form a certain included angle in the circumferential direction of the fiber ring. The fiber arrangement direction between adjacent plate layers is reversely alternated along the left side and the right side of the longitudinal axis.
Example 1
Dissolving a certain amount of polylactic acid-polycaprolactone P (LLA-CL) and regenerated silk fibroin in a hexafluoroisopropanol solution to prepare a spinning solution with the concentration of 10 wt%. Under the environmental conditions of room temperature and 35% relative humidity, the spinning solution is injected into an injector 1, the vertical distance between a needle head 2 and a receiving plate 5 is adjusted to be 100mm, a variable frequency motor 7 is started, the rotating speed of a winding roller 6 is adjusted to be 200r/min, a mandrel motor 11 is started, the horizontal moving speed of the winding roller 6 is adjusted to be 6m/min, a direct current high voltage generator 3 is started, the control voltage is 10kV, the electrostatic spinning nano-fibers are uniformly wound on the winding roller 6, the spinning time is 30min, and the nano-fiber ring with uniform thickness and alternate orientation arrangement is obtained. Experimental results show that the nano-fiber rings obtained by the electrostatic spinning equipment have good hierarchical appearance, and the included angles of the fibers of all layers are basically consistent.
Example 2
Polyethylene oxide (PEO) was dissolved in distilled water at 60 ℃ to prepare a spinning dope having a concentration of 14% by weight. Under the environmental conditions of room temperature and relative humidity of 45%, the spinning solution is injected into an injector 1, the vertical distance between a needle head 2 and a receiving plate 5 is adjusted to be 150mm, a variable frequency motor 7 is started, the rotating speed of a winding roller 6 is adjusted to be 350r/min, a mandrel motor 11 is started, the horizontal moving speed of the winding roller 6 is adjusted to be 8m/min, a direct current high voltage generator 3 is started, the control voltage is 20kV, the electrostatic spinning nano-fibers are uniformly wound on the winding roller 6, the spinning time is 30min, and the nano-fiber ring with uniform thickness and alternate orientation arrangement is obtained. Experimental results show that the nano-fiber rings obtained by the electrostatic spinning equipment have good hierarchical appearance, and the included angles of the fibers of all layers are basically consistent.
Example 3
Polyvinyl alcohol (PVA)1788 type powder was dissolved in distilled water at 70 ℃ to prepare a spinning solution having a concentration of 18 wt%. Under the environmental conditions of room temperature and relative humidity of 60%, the spinning solution is injected into an injector 1, the vertical distance between a needle head 2 and a receiving plate 5 is adjusted to be 300mm, a variable frequency motor 7 is started, the rotating speed of a winding roller 6 is adjusted to be 500r/min, a mandrel motor 11 is started, the horizontal moving speed of the winding roller 6 is adjusted to be 10m/min, a direct current high voltage generator 3 is started, the control voltage is 30kV, the electrostatic spinning nano-fibers are uniformly wound on the winding roller 6, the spinning time is 30min, and the nano-fiber ring with uniform thickness and alternate orientation arrangement is obtained. Experimental results show that the nano-fiber rings obtained by the electrostatic spinning equipment have good hierarchical appearance, and the included angles of the fibers of all layers are basically consistent.
Claims (1)
1. The method for preparing the intervertebral disc annulus is characterized in that an electrostatic spinning device for preparing the intervertebral disc annulus is adopted, and the electrostatic spinning device comprises a liquid supply spinning device, a receiving device and a winding and looping device;
the liquid supply spinning device comprises an injector (1), the injector (1) is provided with a needle head (2), and the needle head (2) is connected with the anode of a direct-current high-voltage generator (3);
the receiving device is used for receiving and lapping the nano fibers;
the winding and looping device comprises a winding roller (6) for winding the nano fiber overlapped on the receiving device into a fiber loop; the receiving device comprises two parallel vertically fixed receiving plates (5), the nanofiber is lapped between the two receiving plates (5), the winding roller (6) is positioned between the two receiving plates (5), the two receiving plates (5) are fixed on a receiving plate bracket (9), and the receiving plates (5) are connected with a grounding wire (12); the winding roller (6) is arranged on the transmission shaft (4) and performs circumferential self-rotation movement and horizontal movement along with the transmission shaft (4);
the winding and looping device further comprises a transmission shaft support (8), two ends of the transmission shaft (4) are respectively connected with a left support and a right support of the transmission shaft support (8), the transmission shaft support (8) is connected with a mandrel motor (11), and the mandrel motor (11) drives the transmission shaft support (8) to move horizontally;
the transmission shaft (4) is connected with a variable frequency motor (7), and the variable frequency motor (7) drives the transmission shaft (4) to rotate so as to drive the winding roller (6) to rotate circumferentially;
the method is implemented by the following steps:
injecting the spinning solution into an injector (1), and adjusting the distance between a needle head (2) and a receiving plate (5) under the environmental conditions of room temperature and 35-60% of relative humidity; starting a direct-current high-voltage generator (3), adjusting an external voltage to stabilize liquid drops and jet flow, starting a variable frequency motor (7) and a mandrel motor (11), driving a winding roller (6) to horizontally reciprocate at a certain speed and simultaneously rotate circumferentially, and finally obtaining fiber rings on the winding roller (6);
the circumferential rotating speed of the winding roller (6) is 200 r/min-500 r/min;
the horizontal moving speed of the winding roller (6) is 6-10 m/min;
the vertical distance between the needle head (2) and the two parallel receiving plates (5) is 100-300 mm;
the external voltage is 10 kV-30 kV.
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| CN201711390291.XA CN108034994B (en) | 2017-12-21 | 2017-12-21 | Electrostatic spinning device and method for preparing intervertebral disc fibrous ring |
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| CN109972292A (en) * | 2019-04-30 | 2019-07-05 | 中国科学院苏州纳米技术与纳米仿生研究所南昌研究院 | The method and system of material surface in-stiu coating Electrospun nano-fibers film |
| CN113413772A (en) * | 2021-03-22 | 2021-09-21 | 常州膜达环保科技有限公司 | Preparation method and equipment of high-strength polyvinylidene fluoride hollow fiber membrane |
| CN113604904A (en) * | 2021-09-02 | 2021-11-05 | 和也健康科技有限公司 | Preparation method, product and application of fusiform ternary @ carbon @ stone needle nanofiber material |
| CN115323612A (en) * | 2022-08-19 | 2022-11-11 | 佛山清立新材料科技有限公司 | High-thermal-conductivity composite material and preparation method thereof |
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