CN108031975A - A kind of induced with laser implantation preparation method of continuous multilayer drop parcel - Google Patents
A kind of induced with laser implantation preparation method of continuous multilayer drop parcel Download PDFInfo
- Publication number
- CN108031975A CN108031975A CN201711003709.7A CN201711003709A CN108031975A CN 108031975 A CN108031975 A CN 108031975A CN 201711003709 A CN201711003709 A CN 201711003709A CN 108031975 A CN108031975 A CN 108031975A
- Authority
- CN
- China
- Prior art keywords
- layer
- dielectric layer
- drop
- induced
- glass substrate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
- B23K—SOLDERING OR UNSOLDERING; WELDING; CLADDING OR PLATING BY SOLDERING OR WELDING; CUTTING BY APPLYING HEAT LOCALLY, e.g. FLAME CUTTING; WORKING BY LASER BEAM
- B23K26/00—Working by laser beam, e.g. welding, cutting or boring
- B23K26/352—Working by laser beam, e.g. welding, cutting or boring for surface treatment
Abstract
Induced with laser the invention discloses a kind of continuous multilayer drop parcel is implanted into preparation method, includes the following steps：S1：The preparation of a variety of media；S2：The laser beam (1) of pulse is from glass substrate (3) vertical incidence, laser beam (1) passes through glass substrate (3), focus on the one side of the first layer dielectric layer (4), when the energy of laser beam (1) is more than the breakdown threshold of first layer medium (4), the plasma (2) of high temperature and pressure, plasma (2) external radiation blast wave will be produced；S3：Externally radiation blast wave promotes first layer dielectric layer (4) to form molten melt drop (5) to plasma (2), in the second layer medium (6) and third layer dielectric layer (7) of the embedded lower section of molten melt drop (5), multilayer drop insertion (8) is formed.The present invention obtains two layers uniform in size controllable, can precisely to be manipulated to single drop or the drop parcel of multilayer by induced with laser transfer techniques forward.
Description
Technical field
The present invention relates to a kind of induced with laser be implanted into preparation method, more particularly to a kind of continuous multilayer drop parcel swash
Photoinduction is implanted into preparation method.
Background technology
The drop technique for packing of fine volume is detected in biologic medical, molecular biology, and chemical industry chemistry, Food Science, changes
There is very big application value in the field such as cosmetic application and engineer application.The drop of fine volume can be as the miniature of chemical reaction
Reactor, the medicine package shipment of medical treatment and release, the unicellular progress biological detection analysis of parcel, the digitlization based on drop
PCR (PCR), organizational project, diagnosing image and other Engineerings apply [1].Micro-fluidic chip generates at present
Drop is main drop formation mode, and drop is as a kind of new fluid motion occurred in recent years on micro-fluidic chip
Form, each drop can be considered as independent microreactor, study the reaction on micro-dimension and its process.Apply upper
State in application field, based on drop, the materials such as the macromoleculars such as chemical reagent, cell, protein, microparticle can be carried out
Manipulation, the experiment condition of each reaction of more precise control, more flexible control participate in the actual use of each component of reaction
Amount, shortens the reaction time.
Specific drop formation principle：Drop is produced using two kinds of immiscible liquid in micro-fluidic chip, is with it
A kind of middle liquid is as continuous phase, using another liquid as dispersed phase, is manipulated by the channel design and external force of chip,
Dispersed phase can be cut into uniform micro volume unit and is scattered in continuous phase by continuous phase, that is, form drop.In micro-fluidic core
On piece can make that the droplet size of generation is homogeneous, property is stable, composition is uniform by controlling two-phase flow velocity.Drop formation method
Mainly multiphase flow method, makes dispersed phase fluid produce velocity variations ladder in path partially by the design to fluid channel structure
Degree, drop is generated using the interaction of the shearing force between two-phase, stickiness power and surface tension.Multiphase flow method can batch
Generate drop, easily carry out overall manipulation to batch drop, shortcoming be to the shell thickness or internal chamber structure of single drop and
The accuracy controlling of component etc.[2].According to the difference of PDMS base micro fluidic device geometries and liquid phase fluid flow direction
Difference, the generation of microlayer model can be divided into following 5 kinds of citation forms：(1) two-dimentional extrusion structure；(2) T types microchannel；(3) flow
Focus type microchannel；(4) common focus type microchannel；(5) Y types microchannel (as shown in Fig. 3 a-h).Built with glass capillary
Micro fluidic device can be divided into single emulsion drop and two kinds of structures of emulsion drop (such as Fig. 3 i-k institutes again according to the diversity of nested structure
Show)[3]。
Then the generation type of drop is together in series when needing the multilayer of drop to wrap up to obtain multilayer drop bag
Wrap up in, as shown in Figure 4.
The shortcomings that prior art：Existing micro-fluidic chip controls droplet size, liquid by controlling the speed of dispersed phase
It is relatively low to drip the uniformity, and needs to sort；It is difficult to the essence of the shell thickness or internal chamber structure and component etc. to single drop
Really regulation and control；A kind of micro-fluidic chip only corresponds to a kind of drop of size.
The content of the invention
It is an object of the invention to propose that a kind of induced with laser of continuous multilayer drop parcel is implanted into preparation method, pass through
Induced with laser transfer techniques forward, obtain uniform in size controllable, and the parcel number of plies, thickness are controllable, and parcel material optionally can be to list
Precisely manipulate two layers of a drop or the drop of multilayer parcel.
The technical solution adopted in the present invention：A kind of induced with laser implantation preparation method of continuous multilayer drop parcel, bag
Include following steps：
S1：The preparation of a variety of media：Specially apply on a glass substrate and scrape first layer dielectric layer (4), in the first layer
Storing apparatus is equipped with below dielectric layer (4), the storing apparatus is equipped with second dielectric layer (6) successively from top to bottom, third layer is situated between
Matter layer (7) and the 4th layer of dielectric layer (10)；
S2：The laser beam (1) of pulse passes through glass substrate from glass substrate (3) vertical incidence, laser beam (1)
(3), the one side of the first layer dielectric layer (4) is focused on, when the energy of laser beam (1) is more than hitting for first layer medium (4)
When wearing threshold value, it will produce the plasma (2) of high temperature and pressure, plasma (2) external radiation blast wave；
S3：Externally radiation blast wave promotes first layer dielectric layer (4) to form molten melt drop (5), melting to plasma (2)
In the second layer medium (6) and third layer dielectric layer (7) of the embedded lower section of drop (5), multilayer drop insertion (8) is formed；Formed
Multilayer drop insertion (8) is ejected into the 4th layer of dielectric layer (10) further along, due to the stickiness of the 4th layer of dielectric layer (10)
The effect of power and surface tension and then formation multilayer drop parcel (9), make multilayer liquid under the resistance of the 4th layer of dielectric layer (10)
Drop parcel (9) driving force slows down, and ultimately forms complete drop；
S4：Glass substrate (3) movement, repeat step S2, S3 are driven by preset direction；Complete the system of multilayer drop
It is standby.
Preferably, the first layer dielectric layer (4) is liquid, suspension or solid film containing attritive powder.
Preferably, the second dielectric layer (6), third layer dielectric layer (7) and the 4th layer of dielectric layer (10) are different densities
Liquid.
Preferably, the movement of the glass substrate (3) is driven described in step S4 by preset direction, is specially：With parallel to
Axis centered on the default straight line in laser beam (1) direction, drives the glass substrate (3) to move by circumferencial direction.
Preferably, the density of the second dielectric layer (6) is less than the density of third layer dielectric layer (7), and the third layer is situated between
The density of matter layer (7) is less than the density of the 4th layer of dielectric layer (10).
Preferably, the laser beam (1) is fixed on above the glass substrate (3).
Compared with prior art, the beneficial effects of the invention are as follows：(1) laser beam (1) induction of the present invention produces plasma
Body (2) promotes the first layer dielectric layer (4) for being applied to glass substrate to pass through the layer liquid generation multilayer drop bag in storing apparatus
Wrap up in, by adjusting change laser energy, the number of plies, thickness and the material of focus spot diameter and sample preparation obtain different rulers
The multilayer drop that single drop can be precisely the manipulated parcel of very little, the different numbers of plies, a variety of materials of different Jacket thickness；
(2) the method for the present invention can continuously generate the drop parcel of multilayer；Can be more to realize by adjusting laser parameter and sample preparation
The drop parcel of the more sizes of thickness；(3) the droplet size size uniform of the method for the present invention generation；(4) method of the invention can be right
Single drop is precisely manipulated, is avoided the difficulty of liquid spin coating, simplifies the process that multilayer liquid prepares spin coating；(5) originally
Inventive method is not limited solely to the parcel of liquid and liquid, and liquid on glass substrate can also be changed into solid target can realize
The parcel of solid and liquid, has the advantages that high throughput, formation efficiency are high, manufacturing cost is low etc..
Brief description of the drawings
Fig. 1 is the schematic diagram that a kind of induced with laser of continuous multilayer drop parcel of the present invention is implanted into preparation method.
Fig. 2 is the preparation principle figure that the present invention automatically generates multilayer liquid.
Fig. 3 is microlayer model generating means schematic diagram common in the art.
Fig. 4 is that the series connection of droplet formation forms multilayer drop parcel schematic diagram.
Embodiment
Technical scheme is further illustrated with reference to specific embodiment.
As shown in Figs. 1-2, the induced with laser implantation preparation method of a kind of continuous multilayer drop parcel, includes the following steps：
S1：The preparation of a variety of media：Specially apply on a glass substrate and scrape first layer dielectric layer (4), in the first layer
Storing apparatus is equipped with below dielectric layer (4), the storing apparatus is equipped with second dielectric layer (6) successively from top to bottom, third layer is situated between
Matter layer (7) and the 4th layer of dielectric layer (10)；
S2：The laser beam (1) of pulse passes through glass substrate from glass substrate (3) vertical incidence, laser beam (1)
(3), the one side of the first layer dielectric layer (4) is focused on, when the energy of laser beam (1) is more than hitting for first layer medium (4)
When wearing threshold value, it will produce the plasma (2) of high temperature and pressure, plasma (2) external radiation blast wave；
S3：Externally radiation blast wave promotes first layer dielectric layer (4) to form molten melt drop (5), melting to plasma (2)
In the second layer medium (6) and third layer dielectric layer (7) of the embedded lower section of drop (5), multilayer drop insertion (8) is formed；Formed
Multilayer drop insertion (8) is ejected into the 4th layer of dielectric layer (10) further along, due to the stickiness of the 4th layer of dielectric layer (10)
The effect of power and surface tension and then formation multilayer drop parcel (9), make multilayer liquid under the resistance of the 4th layer of dielectric layer (10)
Drop parcel (9) driving force slows down, and ultimately forms complete drop；
S4：Glass substrate (3) movement, repeat step S2, S3 are driven by preset direction；Complete the system of multilayer drop
It is standby.
In the concrete technical scheme of the present invention, the first layer dielectric layer (4) is outstanding for liquid, containing attritive powder
Turbid or solid film；The second dielectric layer (6), third layer dielectric layer (7) and the 4th layer of dielectric layer (10) are different densities
Liquid；The density of the second dielectric layer (6) is less than the density of third layer dielectric layer (7), the third layer dielectric layer (7)
Density be less than the density of the 4th layer of dielectric layer (10).The species and quantity of first layer dielectric layer (4) can be according to actual need
Make choice, generally at least two kinds；The second dielectric layer (6), third layer dielectric layer (7) and the 4th layer of dielectric layer
(10) it is liquid, even laminating is produced in storing apparatus using the physical action between liquid and liquid or chemical action.
Further, the movement of the glass substrate (3) is driven described in step S4 by preset direction, is specially：With parallel
The axis centered on the default straight line in laser beam (1) direction, drives the glass substrate (3) to move by circumferencial direction, described to swash
Light light beam (1) is fixed on above the glass substrate (3).
It should be noted that the laser beam (1) of pulse passes through glass from glass substrate (3) vertical incidence, laser (1)
Substrate (3), focuses on the one side for scribbling first layer dielectric layer (4), when laser energy is more than the breakdown of first layer dielectric layer (4)
During threshold value, it will produce the plasma (2) of high temperature and pressure, plasma (2) external radiation blast wave；Laser beam (1) wink
When high energy promote first layer dielectric layer (4) to form second dielectric layer (6) and the third layer Jie of the embedded lower section of molten melt drop (5)
In matter layer (7), multilayer drop insertion (8) is formed；The multilayer drop insertion (8) of formation is ejected into the 4th layer of Jie further along
In matter layer (10), effect and then formation multilayer drop parcel (9) due to Liquid Viscous power and surface tension.
Automatically generate the preparation principle of multilayer liquid：As shown in Fig. 2, in order to avoid difficulty prepared by liquid target material, this is specially
Profit produces uniform second dielectric layer (6) and the in a reservoir using the physical action between liquid and liquid or chemical action
Three layers of dielectric layer (7), when molten melt drop (5) passes through second dielectric layer (6) and third layer dielectric layer (7) since liquid has
Mobility can automatically form uniform layer liquid, and thus circulation can realize the preparation for automatically generating multilayer conforming layer liquid, from
And simplify the process for preparing multilayer liquid parcel.
Continuous multilayer drop wraps up implementation：As shown in Fig. 2, the laser beam (1) of fixed pulse, with glass substrate
(3) be used as turntable, it is rotating by direction of rotation (A) cycle in a manner of rotate the glass substrate (3) for scribbling first layer dielectric layer (4),
Step S2-S4 is carried out, is embedded into the diverse location formation molten melt drop (5) that laser beam acts on first layer dielectric layer (4)
Second dielectric layer (6), third layer dielectric layer (7) and the 4th layer of dielectric layer (10), so that continuous preparation multilayer liquid can be realized
The parcel of drop, improves the preparation efficiency of multilayer drop parcel.
For those skilled in the art, technical solution that can be as described above and design, make other each
Kind is corresponding to be changed and deforms, and all these change and deform the protection that should all belong to the claims in the present invention
Within the scope of.
Claims (7)
- A kind of 1. induced with laser implantation preparation method of continuous multilayer drop parcel, it is characterised in that：Include the following steps：S1：The preparation of a variety of media：Specially apply on a glass substrate and scrape first layer dielectric layer (4), in the first layer medium Storing apparatus is equipped with below layer (4), the storing apparatus is equipped with second dielectric layer (6), third layer dielectric layer successively from top to bottom (7) and the 4th layer of dielectric layer (10)；S2：For the laser beam (1) of pulse from glass substrate (3) vertical incidence, laser beam (1) passes through glass substrate (3), focuses on In the one side of the first layer dielectric layer (4), when the energy of laser beam (1) is more than the breakdown threshold of first layer medium (4), The plasma (2) of high temperature and pressure, plasma (2) external radiation blast wave will be produced；S3：Externally radiation blast wave promotes first layer dielectric layer (4) to form molten melt drop (5), molten melt drop to plasma (2) (5) in the second layer medium (6) and third layer dielectric layer (7) of embedded lower section, multilayer drop insertion (8) is formed；The multilayer of formation Drop insertion (8) be ejected into further along in the 4th layer of dielectric layer (10), due to the 4th layer of dielectric layer (10) stickiness power and The effect of surface tension and then formation multilayer drop parcel (9), make multilayer drop bag under the resistance of the 4th layer of dielectric layer (10) Wrap up in (9) driving force to slow down, ultimately form complete drop.
- A kind of 2. induced with laser implantation preparation method of continuous multilayer drop parcel according to claim 1, it is characterised in that： Further include S4：Glass substrate (3) movement, repeat step S2, S3 are driven by preset direction；Complete the preparation of multilayer drop.
- A kind of 3. induced with laser implantation preparation method of continuous multilayer drop parcel according to claim 1, it is characterised in that： The first layer dielectric layer (4) is liquid, suspension or solid film containing attritive powder.
- A kind of 4. induced with laser implantation preparation method of continuous multilayer drop parcel according to claim 1, it is characterised in that： The second dielectric layer (6), third layer dielectric layer (7) and the 4th layer of dielectric layer (10) are the liquid of different densities.
- A kind of 5. induced with laser implantation preparation method of continuous multilayer drop parcel according to claim 2, it is characterised in that： The movement of the glass substrate (3) is driven described in step S4 by preset direction, is specially：With parallel to laser beam (1) direction Default straight line centered on axis, drive the glass substrate (3) to move by circumferencial direction.
- A kind of 6. induced with laser implantation preparation method of continuous multilayer drop parcel according to claim 1, it is characterised in that： The density of the second dielectric layer (6) is less than the density of third layer dielectric layer (7), and the density of the third layer dielectric layer (7) is small In the density of the 4th layer of dielectric layer (10).
- A kind of 7. induced with laser implantation preparation method of continuous multilayer drop parcel according to claim 1, it is characterised in that： The laser beam (1) is fixed on above the glass substrate (3).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711003709.7A CN108031975B (en) | 2017-10-24 | 2017-10-24 | Laser-induced implantation preparation method for continuous multilayer liquid drop wrapping |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711003709.7A CN108031975B (en) | 2017-10-24 | 2017-10-24 | Laser-induced implantation preparation method for continuous multilayer liquid drop wrapping |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN108031975A true CN108031975A (en) | 2018-05-15 |
| CN108031975B CN108031975B (en) | 2020-02-21 |
Family
ID=62093371
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711003709.7A Active CN108031975B (en) | 2017-10-24 | 2017-10-24 | Laser-induced implantation preparation method for continuous multilayer liquid drop wrapping |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108031975B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113340693A (en) * | 2021-06-17 | 2021-09-03 | 重庆大学 | Photo-thermal control liquid drop three-dimensional migration device and using method |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009198710A (en) * | 2008-02-20 | 2009-09-03 | Hitachi Chem Co Ltd | Photosensitive resin composition, and photosensitive film, resist pattern forming method and permanent resist using the same |
| CN101792651A (en) * | 2009-01-30 | 2010-08-04 | E.I.内穆尔杜邦公司 | Wafer level, chip scale semiconductor device packaging compositions, and methods relating thereto |
| CN102676124A (en) * | 2012-05-04 | 2012-09-19 | 广东工业大学 | Inorganic hydrous salt phase change energy storage microcapsule and preparation method thereof |
| CN102822903A (en) * | 2010-04-09 | 2012-12-12 | 西默股份有限公司 | Systems and method for target material delivery protection in a laser produced plasma EUV light source |
| US20130217103A1 (en) * | 2010-03-30 | 2013-08-22 | Advanced Liquid Logic Inc | Droplet Operations Platform |
| CN105233893A (en) * | 2015-11-02 | 2016-01-13 | 华东理工大学 | Method for preparing micro-droplets based on micro-fluidic chip modification technology |
| CN106890683A (en) * | 2017-03-14 | 2017-06-27 | 广东工业大学 | A kind of forming method of multilayer drop parcel |
| CN107064091A (en) * | 2017-04-19 | 2017-08-18 | 中国科学院电子学研究所 | A kind of micro-fluidic chip, single cell protein quantitative testing device and method |
-
2017
- 2017-10-24 CN CN201711003709.7A patent/CN108031975B/en active Active
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009198710A (en) * | 2008-02-20 | 2009-09-03 | Hitachi Chem Co Ltd | Photosensitive resin composition, and photosensitive film, resist pattern forming method and permanent resist using the same |
| CN101792651A (en) * | 2009-01-30 | 2010-08-04 | E.I.内穆尔杜邦公司 | Wafer level, chip scale semiconductor device packaging compositions, and methods relating thereto |
| US20130217103A1 (en) * | 2010-03-30 | 2013-08-22 | Advanced Liquid Logic Inc | Droplet Operations Platform |
| CN102822903A (en) * | 2010-04-09 | 2012-12-12 | 西默股份有限公司 | Systems and method for target material delivery protection in a laser produced plasma EUV light source |
| CN102676124A (en) * | 2012-05-04 | 2012-09-19 | 广东工业大学 | Inorganic hydrous salt phase change energy storage microcapsule and preparation method thereof |
| CN105233893A (en) * | 2015-11-02 | 2016-01-13 | 华东理工大学 | Method for preparing micro-droplets based on micro-fluidic chip modification technology |
| CN106890683A (en) * | 2017-03-14 | 2017-06-27 | 广东工业大学 | A kind of forming method of multilayer drop parcel |
| CN107064091A (en) * | 2017-04-19 | 2017-08-18 | 中国科学院电子学研究所 | A kind of micro-fluidic chip, single cell protein quantitative testing device and method |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113340693A (en) * | 2021-06-17 | 2021-09-03 | 重庆大学 | Photo-thermal control liquid drop three-dimensional migration device and using method |
Also Published As
| Publication number | Publication date |
|---|---|
| CN108031975B (en) | 2020-02-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20170058410A1 (en) | Devices and methods for forming double emulsion droplet compositions and polymer particles | |
| JP6367717B2 (en) | Fast on-demand droplet generation and single-cell encapsulation driven by induced cavitation | |
| Baigl | Photo-actuation of liquids for light-driven microfluidics: state of the art and perspectives | |
| JP5174481B2 (en) | Centrifugal force-based microfluidic device for dilution and microfluidic system comprising the same | |
| CN104324769B (en) | Generation method based on the drop of microchannel | |
| WO2016078339A1 (en) | Apparatus, system, and method for generating micro liquid droplets and single-cell/single-molecule analysis apparatus | |
| EP2420319A1 (en) | Centrifugal microfluidic device having sample distribution structure and centrifugal microfluidic system including the centrifugal microfluidic device | |
| Udofia et al. | A guiding framework for microextrusion additive manufacturing | |
| JP2012531302A (en) | Fluid injection | |
| CN104492508B (en) | A kind of ultramicron liquid drop control device and method based on liquid residue | |
| CA3001954A1 (en) | Microfluidic arrangements | |
| JP2004529333A (en) | Structural unit that defines fluid function | |
| CN107110761B (en) | Device for real-time analysis of particles suspended in a fluid and method for analyzing said particles | |
| JP7138301B2 (en) | Microdroplet container, microdroplet container manufacturing method, microdroplet spreading method, microdroplet generating reagent kit, temperature control device, oil phase composition for microdroplet generation, and processing method thereof | |
| Bhattacharjee et al. | Electrocoalescence based serial dilution of microfluidic droplets | |
| CN108031975A (en) | A kind of induced with laser implantation preparation method of continuous multilayer drop parcel | |
| Mohammadrashidi et al. | Experimental and theoretical investigation on the dynamic response of ferrofluid liquid marbles to steady and pulsating magnetic fields | |
| CN106890683B (en) | A kind of forming method of multilayer drop package | |
| CN114260035B (en) | Multilayer wrapped micro-fluidic chip and cell particle generator | |
| JP2005238118A (en) | Method and device for preparing solidified particle using micro-flow channel structure | |
| Dunne et al. | Stimuli-controlled fluid control and microvehicle movement in microfluidic channels | |
| US20240042436A1 (en) | Micro-droplet generation method and generation system | |
| Wang et al. | A novel approach for encapsulating cells into monodisperse picolitre droplets actuated by microfluidic pulse inertia force | |
| CN109999933B (en) | Centrifugal liquid drop generating device | |
| RU199373U1 (en) | Microfluidic device for forming monodisperse macroemulsion by vacuum method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |