CN108025156A - Breathe component - Google Patents
Breathe component Download PDFInfo
- Publication number
- CN108025156A CN108025156A CN201680055181.5A CN201680055181A CN108025156A CN 108025156 A CN108025156 A CN 108025156A CN 201680055181 A CN201680055181 A CN 201680055181A CN 108025156 A CN108025156 A CN 108025156A
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- CN
- China
- Prior art keywords
- sleeve
- component according
- breathing component
- pair
- cylinder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/08—Bellows; Connecting tubes ; Water traps; Patient circuits
- A61M16/0816—Joints or connectors
- A61M16/0825—Joints or connectors with ball-sockets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
- A61B5/082—Evaluation by breath analysis, e.g. determination of the chemical composition of exhaled breath
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
- A61B5/097—Devices for facilitating collection of breath or for directing breath into or through measuring devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/0057—Pumps therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/04—Tracheal tubes
- A61M16/0488—Mouthpieces; Means for guiding, securing or introducing the tubes
- A61M16/049—Mouthpieces
- A61M16/0493—Mouthpieces with means for protecting the tube from damage caused by the patient's teeth, e.g. bite block
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/06—Respiratory or anaesthetic masks
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/06—Respiratory or anaesthetic masks
- A61M16/0666—Nasal cannulas or tubing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/06—Respiratory or anaesthetic masks
- A61M16/0683—Holding devices therefor
- A61M16/0688—Holding devices therefor by means of an adhesive
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/08—Bellows; Connecting tubes ; Water traps; Patient circuits
- A61M16/0875—Connecting tubes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/06—Respiratory or anaesthetic masks
- A61M16/0605—Means for improving the adaptation of the mask to the patient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/06—Respiratory or anaesthetic masks
- A61M16/0683—Holding devices therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/08—Bellows; Connecting tubes ; Water traps; Patient circuits
- A61M16/0816—Joints or connectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/06—Respiratory or anaesthetic masks
- A61M2016/0661—Respiratory or anaesthetic masks with customised shape
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/06—Head
- A61M2210/0618—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/06—Head
- A61M2210/0625—Mouth
Abstract
The present invention provides a kind of breathing component, the component include engage with least one connector and with hose or the pedestal of fluid fluid communication, to allow the gas circulation between at least one connector, pedestal and hose or fluid source.The component further includes a pair of of the sleeve engaged with least one connector and a pair of columns, each cylinder is optionally engaged with least one sleeve in a pair of of sleeve, wherein each cylinder includes the flange for limiting the opening passed through, and the opening is connected with each corresponding sleeve fluid in a pair of of sleeve；Each cylinder further includes the adhesive for adhering to each flange and being arranged to sealingly engage patient nostril.
Description
Cross reference to related applications
The application is 14/876009, the 2016 year September 13 of U.S. Patent application submitted on October 6th, 2015 to a certain extent
The U.S. Patent application submitted for 13rd of 26/916445,2016 year September of U.S. Patent application day submitted 26/916453,2016 year
The temporary patent application 62/495576 that the U.S. Patent application 26/916474 and September in 2016 that September is submitted on the 13rd are submitted on the 13rd
Continuity, these patents are incorporated hereby herein.
The U.S. Patent application 13/672946 submitted this application involves on November 9th, 2012, and it is used as United States Patent (USP)
9,149,595 announce, it requires the priority for the U.S. Provisional Patent Application 61/562056 submitted on November 21st, 2011,
It is now expired, its content is integrally incorporated by reference herein.
Technical field
This disclosure relates to breathe component, and relate more specifically to the nose for being used for the sealable engagement for providing treatment fluid
The breathing component of hole bonding part.
Background technology
Patient with any sleep or respiratory disorder during continuous positive pressure ventilation mask is used to treat sleep.CPAP faces
Treatment fluid such as surrounding air or oxygen-enriched air can be delivered to patient by cover under the setting of predetermined or desired pressure.
CPAP masks have many defects, for example, CPAP masks are heavy so that they aesthetics and ergonomics on not
It is too satisfactory.CPAP masks must with the sealing engagement of patient skin, so as to maintain sealing environment it is defeated to reach treatment fluid
Send required pressure.Being bonded on patient skin for this sealing leaves wear trace, and wear trace disappears and may need
Long time.Therefore, many patients do not feel well in public before wear trace disappearance, and male patient can
It can shave, female patient cannot smear cosmetics before wear trace disappearance.These depressions or trace are probably by wrapping
Caused by wrapping up in the mask of mouth and/or nostril and the band or connector of patients head's positioning may being surrounded.
Due to the heavy property of traditional CPAP masks, mask occupies a big chunk of face.Which has limited people to sleep
Moving-head during dormancy, because CPAP masks may be contacted and mask and patient are departed from sealing engagement by lying in face side,
So as to empty the pressure in face shield assembly.This is undesirable because patient under desired pressure without receive treatment gas or
Patient is waken up.
Therefore, it is necessary to a kind of improved CPAP breathings component, which solves relevant scarce with routine CPAP machines and mask
Point.Furthermore, it is necessary to which the CPAP without band and without mask breathes component, the huge and impression of tradition CPAP machines and mask is thus solved
The characteristic of formation.
The content of the invention
This general introduction be in order to introduce in simplified form will be described in detail below in some concepts for further describing.This
The content of the invention is not intended to determine the key feature or essential characteristic of theme claimed, is also not intended to be used to limit institute
The scope of claimed theme.
According at least one embodiment, there is provided one kind breathing component.Breathing component includes and at least one connector and soft
Pipe or the pedestal of fluid source engagement, to allow the gas between at least one connector and hose or fluid source to circulate；With institute
State a pair of of sleeve of at least one connector engagement；A pair of columns, each cylinder optionally with the pair of sleeve
At least one engagement, wherein each cylinder includes：Limit the flange of opening wherein, the opening with the pair of sleeve
Each corresponding sleeve gas connection；Apply adhesive to each flange and be configured to sealingly engage the nostril of patient.
According at least one embodiment, there is provided one kind breathing component.Breathing component includes：With at least one connector and soft
Pipe or the pedestal of fluid source engagement, for allowing the gas between at least one connector and hose or fluid source to circulate；With
A pair of of sleeve of at least one connector engagement；A pair of of cleat assembly, each cleat assembly is optionally with described one
To at least one engagement in sleeve, wherein each cleat assembly limits：With including the adhesive for engaging patient nostril
The clamping plate flange of sheet material engagement；With the clamping plate opening of each corresponding sleeve gas connection in the pair of sleeve；It is at least one
Clamping plate ridge, at least one sleeve ridge of one being selectively engaged in the pair of sleeve.
Brief description of the drawings
General introduction above and following detailed description of the preferred embodiment may be better understood when being read in conjunction with the figure.
For illustrative purposes, exemplary embodiment is shown in the drawings；However, presently disclosed invention is not limited to disclosed tool
Body method and means.In the accompanying drawings：
Attached drawing 1 is shown according to one or more breathing masks of embodiment disclosed herein and the schematic diagram of patient to be treated；
Attached drawing 2 shows the schematic diagram of the mask according to one or more embodiments disclosed herein；
Attached drawing 3 is shown according to one or more nasal assemblies of embodiment disclosed herein and the schematic diagram of patient to be treated；
Attached drawing 4 shows the nasal assembly partial schematic diagram according to one or more embodiments disclosed herein；
Attached drawing 5A and 5B show the nose group being used together with breathing mask according to one or more embodiments disclosed herein
The corresponding perspective view and side view of part；
Attached drawing 6 shows the breathing component with pedestal and single connector according to one or more embodiments disclosed herein
Perspective view；
Attached drawing 7 shows the breathing component with pedestal and two connectors according to one or more embodiments disclosed herein
Rearview；
Attached drawing 8 shows the pedestal of the breathing component with two openings according to one or more embodiments disclosed herein
Schematic diagram；
Attached drawing 9 shows the base of the breathing component with two pedestal openings according to one or more embodiments disclosed herein
The bottom view of seat；
Attached drawing 10 is shown according to the breathing components with two pedestal openings of one or more embodiments disclosed herein
The rearview of pedestal；
Attached drawing 11 is shown has four pedestal openings and two caps according to one or more embodiments disclosed herein
Breathe the rearview of the pedestal of component；
Attached drawing 12 shows the cleat assembly and rotatable sleeve assembly according to one or more embodiments disclosed herein；
Attached drawing 13A-13D is shown according to one or more sleeve assemblies of embodiment disclosed herein and the schematic diagram of cylinder；
Attached drawing 14A shows the signal with the sleeve assembly for clamping lock according to one or more embodiments disclosed herein
Figure；
Attached drawing 14B shows the vertical view with the sleeve assembly for clamping lock according to one or more embodiments disclosed herein
Figure；
Attached drawing 14C shows the side view with the sleeve assembly for clamping lock according to one or more embodiments disclosed herein
Figure；
Attached drawing 14D is shown has looking up for the sleeve assembly for clamping lock according to one or more embodiments disclosed herein
Figure.
Embodiment
Presently disclosed invention is described in detail to meet legal requirements.However, description is not limiting as this specially in itself
The scope of profit.On the contrary, inventor has been expected, it is desirable to the invention of protection can also otherwise embody, with including with this
Different step or element as the step of described in document or element class, with reference to the technology of other present or futures.
Attached drawing 1 shows the breathing component being installed on patient 1 according at least one embodiment.Such embodiment is
It is described in detail in the U.S. Patent application 13/672,946 that on November 9th, 2012 submits, and is disclosed as United States Patent (USP) 9,
149,595.Component is breathed in whole attached drawing and is designated generally by 10.Component 10 includes nasal assembly 12.Nasal assembly 12
May include at least one cylinder 14, it is located in its first end or near it with nose bonding part 16, the nose bonding part 16,
For treatment gas to be delivered to the nasal cavity of patient 1.Cylinder 14 can be configured as flushing for offer and patient nostril, salable
Engagement.
Breathing component 10 can include face shield assembly 20, which, which has, is used to receive treatment gas from fluid source 41
The entrance 22 of body and at least one container 24 for being sealingly engaged with cylinder 14.Fluid source 41 can be continuous positive pressure ventilation
（CPAP）Machine, fluid tank, humidifier or other fluid sources.Cylinder 14 can be engaged optionally with container 24 so that engagement
It is permanent or only when patient wishes.Alternatively, cylinder 14 can optionally with by wherein carry treatment gas pipe
28 directly engage.
As shown in Figure 2, entrance 22 can include swivel joint 36, to allow entrance 22 around the rotation fortune of face shield assembly 20
It is dynamic.Entrance 22 can be for providing processing gas from fluid source 41 to the hose 40 of the circulation of entrance 22.
Container 24 can include pipe 28, and pipe 28 is configured for flexibly movement so that nasal assembly 12 is positioned at various rulers
The nose of very little each patient.Face shield assembly 20 can be configured to selectively engage and by face with mask body 46
The adhesive pad 42 that cover main body 46 carries is sealingly engaged with patient oral cavity.Gas can be treated with limit chamber 58 in mask body 46
Body enters through the chamber from entrance 22.By this way, under a kind of mode of operation, face shield assembly 20 can be with patient's
Mouth area sealingly engages, and nasal assembly 12 can also be engaged with the nostril of patient or nose region.In this mode of operation
Under, treatment gas can supply oral cavity and the nose region of patient at the same time.Mask body 46 can further limit for this paper into
The casing recessed portions 38 that the connector of one step description coordinates.
Alternatively, panel 44 is provided to be sealingly engaged with face shield assembly 20, with sealed chamber 58 so that treatment gas
The region around patient oral cavity will not be entered, but only pass through nasal assembly 12.In the manner, one disclosed herein or more
A equipment 10 can be suitably configured to wherein treatment patients' gas to they mouth and both noses CPAP apply with
And patient only receives the CPAP applications of the treatment gas of their nose.In addition, if patient be not intended to use provided herein is
Nose joint construction, then can provide one or more connectors 48 to be used together with face shield assembly 20 with sealing container 24.Therefore,
Breathing component 10 described herein can have three kinds of different operator schemes：One of which treatment gas is provided only to patient
Oral cavity, one of which treatment gas is provided only to the nose of patient, and one of which treatment gas is being provided to
The nose and face of patient.
In one or more embodiments, entrance 22 may further include ball as shown in Figure 2 and muff joint 50,
Ball is expressed as 50, and casing recessed portions are represented by 38.Ball and muff joint allow the rotary motion of entrance 22.Ball 50 can limit multiple
Venthole 52, to allow stream of therapeutic gas mistake.The size and location of venthole 52 can be adjusted so as to owning from patient
Breathe out fluid（Such as carbon dioxide）Manipulation by control and it is titratable so that the flow of fluid can be changed to desired set
Put.In alternative embodiments, as shown in attached drawing 3 and attached drawing 4, each pipe 28 of a pair of of pipe 28, each cylinder of a pair of columns 14
14 or both can include being used for the venthole or blow vent 52 for allowing gas to circulate.It is used in addition, blow vent 52 can be adjusted
Titration passes through gas therein.In certain embodiments, venthole 52 can be made of polymer fiber, film or mesh, its
With from nanoscale to micron-sized very small thickness.Polymer fiber can pass through electrospinning PTFE（Polytetrafluoroethylene (PTFE)）Manufacture.
In one or more embodiments, mask body 46 may include adjustable mechanism, which allows to come from cylinder 14
Pipeline be changed, it is mobile or raise to adapt to the face structure of patient, mainly on nose and main body 46 or internal oral cavity
The distance between outer cover port, so as to allow preferable face angle knead dough minister's degree, this can increase the comfort level of patient.For
Comfort, availability and the validity of further increase breathing component 10, nasal assembly 12 and/or face shield assembly 20, software
It can be used for customizing the various shapes and profile for breathing components 10 and/or nasal assembly 12 with printing capability.It is for example, but unlimited
In the nose bonding part 16 of nasal assembly 12 can specifically be configured to each nasal passage for being adapted to patient 1.This customization can be with
Realized by the feature of digital scan patient face to create CAD model or 3D printing.In addition, mask body 46 and/or viscous
Close the various pieces of pad 42 or the overall face contour that can be customized to more effectively be adapted to patient 1.This customization can be applied to
Any part of component 10 is breathed, is included but not limited to, nasal assembly 12, pedestal 90, connector 91, sleeve 94, cleat assembly
80th, sheet material 30 and/or current divider 60.
Attached drawing 3 shows the nasal assembly 12 being installed on patient 1 according at least one embodiment.Nasal assembly 12 can be with
Including a pair of of pipe 28, each pipe 28 and 41 gas connection of hose 40 or fluid source.A pair of of pipe 28 and hose 40 can be integrally formed.
Alternatively, current divider 60 can be positioned at each in a pair of of pipe 28 between hose 40 or fluid source 41.Current divider 60 can
To be engaged with each in a pair of of pipe 28 and hose 40 or fluid source 41, with allow in a pair of of pipe 28 each with
Gas circulation between hose 40 or fluid source 41.Current divider 60, a pair of of pipe 28 and hose 40 can be integrally formed.
Current divider 60 can configure from the engagement of pipe 28 and/or hose 40 or fluid source 41 using a variety of different structures
Realize.The configuration of some structures can allow the pivoting action of bigger between element 28,40,60, at the same keep sealable engagement with
Prevent gas from its leakage.Current divider 60 can have for conjugation tube 28 two pipe abutting ends 62 and for engage hose 40 or
One source abutting end 64 of fluid source 41.Pipe 28 may include pipe current divider receiver 66.Hose 40 or fluid source 41 can include
Source current divider receiver 68.In certain embodiments, receiver 66,68 or abutting end 62,64 can be and corresponding sunk structure
The circumferentially extending structure of engagement.Alternatively, receiver 66,68 or abutting end 62,64 can be and corresponding pipe or shunting spherojoint
The current divider or tube socket of engagement, to allow pipe 28 to move pivotally around current divider 60.
In at least one embodiment, such as in attached drawing 4 embodiment described.Each cylinder 14 of nasal assembly 12 can be with
Including extension 34, for being selectively engaged the correspondingly received part 35 to pipe 28.Cylinder 14 and container 24 or pipe 28
Engagement some different structures can be used to configure.Extension 34 can be used to be selectively engaged depression accordingly to connect
The circumferentially extending part of receiving portions 35.Alternatively, extension 34 can be cylinder spherojoint and receiving portion 35 is tube socket,
And its middle column body spherojoint 34 and tube socket 35 are configured to be used to be selectively engaged, to allow a pair of of pipe 28 to surround a pair of columns
Each pivoting action in 14, as shown in Figure 4.It is one that another alternative embodiment, which can include extension 34,
A rear socket, and receiving portion 35 is that pipe spherojoint, wherein rear socket 34 and pipe spherojoint 35 are configured as optionally connecing
Close to allow this to move pivotally pipe 28 to each in cylinder 14 around this.
According to some embodiments, nasal assembly 12 includes a pair of columns 14.Attached drawing 5A and 5B is according at least one embodiment
Illustrate in greater detail nasal assembly 12.Cylinder 14 can include flange 26, and flange 26 is configured for being applied with thereon
The sheet material 30 of adhesive 32 engages, or alternately, one layer of use of one layer of adhesive 32 or the adhesive including sheet material 30
In bonding and provide the sealing engagement with the nostril of patient 1.Sheet material 30 can have any desired shape, and can be preferred
Ground is wherein including opening to allow to flow through in the opening 29 limited in cylinder 14.Adhesive 32 can be contact adhesive,
So that sheet material 30 can as needed be adhered to and removed from the nostril of patient.Cylinder 16 can be included in the extension in its second end
Part 34, extension 34 are configured for optionally connecing with least one container 24 of a pair of of pipe 28 or corresponding pipe 28
Close.
Adhesive 32（And/or sheet material 30）Can have different thickness, bonding strength and pliability.Each adhesive 32
Between thickness, bonding strength and pliability can be different, and/or can be in each individually change in adhesive 32 itself.
For example, the pliability of adhesive 32 may be firmer for nostril bonding part, and it is more flexible elsewhere.Adhesive
32 can be made of foam medical adhesive tape, surgical tape and/or hypoallergenic adhesive tape.Adhesive 32 can include hydrocolloid band
18 and/or polyurethane reaction layer can be included, when the body temperature of patient makes adhesive 32 warm, the polyurethane reaction layer and nostril
It is more firm.Adhesive 32 can include polyvinyl chloride or expanded polyolefin band and/or acrylic ester adhesive layer.In some implementations
In example, adhesive 32 can include the use of adhesion substance or adhesive tape adheres to layer of cloth on cylinder 14.
In certain embodiments, this can be included therein each cylinder 14 in cylinder 14 flange for limiting opening 29
26, the opening 29 with this to 28 gas connection of each respective tube in pipe 28.In addition, one layer of adhesive 32 or adhesive 32 can
To be applied to each cylinder 14, each cylinder 14 is arranged to sealingly engage the nostril of patient.Adhesive 32 can be by
It is applied on the sheet material 30 towards nasal side of cylinder 14, or adhesive can be applied directly to the flange 26 of cylinder 14
On.Adhesive 32 can be pressure sensitive.
Attached drawing 6 illustrates the perspective view of the breathing component 10 according to one or more embodiments disclosed herein, breathing group
Part 10 has pedestal 90 and single connector 91.It is worth noting that, 6,8 and 11 be all no band and without mask-this with
The advantages of prior art is compared to being significant, in the prior art, bandage and mask are often left a trace on a patient body.Pedestal
90 can include any amount of venthole 52.For example, as shown in Figure 9, venthole 52 can be positioned at the bottom side of pedestal 90
On.Pedestal 90 can also include or define base tube junction surface 103, for being selectively engaged or being connected to hose 40 or fluid source
41.Base tube junction surface 103 and hose 40 or fluid source 41 allow both fully rotating relative to each other.Base portion 90 and base tube connect
Conjunction portion 103 may be integrally formed or be formed separately.Base tube junction surface 103 can relate to any junction surface as described herein, including but
It is not limited to ball-and-socket joint, snap-engagement, clamps engagement, clamping plate engagement or the engagement of other forms.Base tube junction surface 103 can wrap
Include venthole 52 or the surface with texture or profile can be included in order to breathe the operability of component 10 and operation.
The venthole 52 of the present invention can be located at the nearside in any region that fluid flowing occurs.Such as, but not limited to, lead to
Stomata 52 can be placed on pedestal 90, connector 91, cylinder 14, sleeve 94, base tube fastener 103 etc..Venthole 52 can be with
Manufactured using 3D thermoplasticity typography.Venthole 52 can be made of micropore.Micropore can use very thin fibrillation
Matrix creates.Fibrillation can be by polytetrafluoroethylene (PTFE)（PTFE）Form.
Pedestal 90 and single connector 91 can be with unitary construction or separate constructions.For example, pedestal 90 can be by duroplasts structure
Into, and connector 91 can be made of silicones.Breathe the pedestal 90 of component 10, socket 94, pillar 14 and/or other components
It can be made of plastics, such as, but not limited to polypropylene or polyethylene, it can have food or medical grade quality.It is overall or single
Solely construction and the possibility comprising plastics and silicones can be additionally applied to the embodiment described in such as attached drawing 8 and Figure 11
In and other embodiment as described herein.The connector 91 of attached drawing 6 includes connector body 92 and two connector arms 93.Even
Connecing device arm 93 each optionally can engage or be connected with sleeve 94.Sleeve 94 can engage or connect the interior of connector arm 93
Portion（Referring to attached drawing 6）, linking arm 93 outside or inside and outside.In one embodiment, sleeve 94 can be by slipping into connection
Device arm 93（And/or sleeve 94）Groove in and engaged with connector arm 93（And/or the engageable sleeve 94 of cylinder 14）.
Pedestal 90 can be arranged for receiving the liquid flow from hose 40 or fluid source 41.Pedestal 90 can be further
Limit at least one pedestal opening 96.Attached drawing 6 depicts one embodiment, and wherein pedestal includes being used to be selectively engaged or connecting
It is connected to the single pedestal opening 96 of connector 91.In other embodiments, as shown in attached drawing 8 and attached drawing 11, for example, pedestal can
Including more than one pedestal opening 96, to have two in attached drawing 8, there is four in attached drawing 11.It can include any amount of base
Portion's opening 96 is suitable for the various constructions of the profile of various patients 1 to provide.In addition, one or more base portion openings 96 and one
Or the engagement or connection of multiple connectors 91 can use agreement described here.
Attached drawing 7 is shown has pedestal 90 and two connectors 91 according to one or more embodiments disclosed herein
Breathe the rearview of component 10.Pedestal 90 can limit base recess 97, for being engaged when breathing component 10 with the nostril of patient
When by being configured to leave the face of patient allow the lip of patient more freely to move or into wherein.In addition, pedestal 90
It can include one or more base projections 98 and basement tilt portion 99,10 body currently in use of component is breathed for minimizing
Product, thus allow more close to patient face and be easier manipulate breathing component 10 various parts.
The pedestal 90 of attached drawing 7 is defined for being selectively engaged or being connected to each at least two connectors 91
Two base portion openings 96.More than two connector 91 can be provided so that connector 91 can exchange as needed, to change
Shape（So as to air-flow）, angle（So as to position）And/or type, it can include any engagement described herein.Each connection
Device 91 can be formed and is made of the material for deformability so that connector arm 93 can be relative to connector body
92 bendings.Sleeve 94 can be included in breathing component 94 to be selectively engaged or be connected to connector 91.
Attached drawing 8, which is shown, according to one or more embodiments disclosed herein there is two pedestal openings 96 and base tube to connect
The perspective view of the pedestal 90 of the breathing component 10 in conjunction portion 103.Attached drawing 9 is shown according to one or more embodiments disclosed herein
The breathing component 10 with two pedestal openings 96 pedestal 90 bottom view.Attached drawing 10 is shown according to disclosed herein one
The rearview of the pedestal 90 of the breathing component 10 with two pedestal openings 96 of a or multiple embodiments.
Attached drawing 11 shows the backsight of the pedestal 90 of the breathing component 10 according to one or more embodiments disclosed herein
Figure, the breathing component 10 have four pedestal openings 96 and two caps 102.When not in use and/or when pedestal opening 96 not
When being engaged or coupled to connector 91, two caps 102 can cover pedestal opening 96.Pedestal opening 96 can have similar
Size and dimension so that connector 91 can exchange and repositioning is freely located in each opening 96.Such customization is permitted
Perhaps connector 91 is engaged or is connected to any two opening 96 to be most preferably adapted to the nostril of patient patient selectable.Pass through
Permission clamping plate engages or ball and joint engagement or any other engagement permission reorientation more, and/or passes through the column that offer is at an angle of
Body 14 and/or connector 91, when breathing component 10 is engaged, connector 91, connector arm 93 and/or cylinder 14 can be determined
Position is into the nostril of most suitable patient.
Attached drawing 12 shows the cleat assembly 80 and rotatable sleeve group according to one or more embodiments disclosed herein
Part 94.The sheet material 30 of breathing component 10 can be embedded in cleat assembly 80, and wherein cleat assembly 80 prolongs between being limited to the layer of sheet material 30
The clamping plate flange 82 stretched.Alternatively, sheet material 30 and/or adhesive 32 can be applied to the clamping plate flange 82 of cleat assembly 80 towards nose
Side, similar to the nose bonding part 16 of cylinder 14 described here.Sheet material 30, nose bonding part 16 and/or clamping plate flange 82 can
It is variously-shaped to be formed as producing, to coordinate the nostril 4 of numerous types of patient and nostril 3.For example, in figure 6, sheet material 30
It is circular substantially similar to nose 4, and stretched out in side with triangle manner and there is curved vertex；This
The embodiment of sample is to adhere to the surface area that patient 1 provides bigger.As shown in Figure 5, sheet material 30 is substantially circular.
In entire disclosure, clamping plate flange 82 and nose bonding part 16 are interchangeable.In other embodiments, sheet material 30, nose connect
Conjunction portion 16 and/or clamping plate flange 82 can radially be risen and fallen, recessed or raised, so as to meet nose in a manner of meeting
Hole.When being applied on patient 1, sheet material 30 and/or clamping plate flange 82 can be overlapping between nostril 4, to provide extra branch
Support and adhesion.Clamping plate flange 82 can be by similarly shaped and arrangement.
The clamping plate flange 82 of cleat assembly 80 can be rigid, to provide support, or flexible row, suffered from meeting
The nostril 4 of person and the shape in nostril 3.Cleat assembly 80 can further limit clamping plate extension 84, from the center of clamping plate flange 82
Or internal stretch comes out, and away from patient 1.Clamping plate extension 84 can be substantially cylindrical, or can be optional
Ground shaping, for engaging the cylinder 14 or sleeve 94 of nasal assembly 12.Clamping plate extension 84 can limit multiple clamping plate spines
86 in the inside-of clamping plate 84-clamping plate of extension opening 85 and/or the outside of Non-slip material extension 84.Each of clamping plate spine 86
The distal end 87 more farther than near-end 88 apart from clamping plate flange 82 defined by clamping plate ridge 86 can be limited.Distally 87 and near-end 88 can
Be arranged to allow cylinder 14 or sleeve 94 relative to cleat assembly 80 clockwise or counterclockwise.In addition, clamping plate spine 86
Domatic edge 89 can be limited on distal end 87 and/or near-end 88, it is smooth in order to cleat assembly 80 and cylinder 14 or sleeve 94
Rotation and locking.
In alternative embodiments, clamping plate spine 86 and cylinder or sleeve spine 110 can be L-shaped, and cleat assembly
Can also be on the clamping plate flange 82 based on ring spring（It is not shown）.In engagement 94 antiskid plate component 80 of cylinder 14 or sleeve
Period, ridge can be pushed over each other and cylinder 14 or sleeve 94 can be twisted, then, when patient discharges, ring spring
Cleat assembly 80 will be locked, cylinder 14 or sleeve 94 are in place.Sleeve spine 110 can be limited similar to the near of clamping plate spine 86
End and the nearly socket end 112 and remote socket end 114 of distal end 87,88.
Although depicting sleeve 94 in attached drawing 12, cylinder 14 can be engaged similarly selectively with cleat assembly 80.
Sleeve 94 or cylinder 14 can include location identifier（AH）, for allowing patient that there is splint position identifier by alignment
104 desired location identifier（AH）, sleeve 94 or cylinder 14 are selectively engaged to specific desired locations.Sleeve 94
Or cylinder 14 can further limit the clutch features 105 for easily rotational sleeve driving head 106.Socket head 106
It can be rotated freely through around sleeve pedestal 107.At other in embodiment（Attached drawing 13A-D）In, sleeve pedestal 107 can shape
To be engaged with connector 91 and/or connector arm 93.In addition, sleeve 94 or cylinder 14 can include deformable O-ring 108,
When engaged, sleeve 94 or cylinder 14 are sealingly engaged or are connected to cleat assembly 80.In one embodiment, connect in sleeve 94
In the case of the outside for closing or being connected to connector arm 93, connector arm 93 can extend in sleeve 94 and limit for sealing
Sleeve-cylinder 94-14 engagements or the O-ring 108 of connection.
Attached drawing 13A-D shows the sleeve assembly 94 and cylinder 14 according to one or more embodiments disclosed herein.Cylinder
14 can include nose bonding part 16, and nose bonding part 16 is angled relative to column main body 17, for strengthening nose bonding part 16
Relative to the positioning in nostril.The angle can be any angle between 15 degree or 0 degree to 45 degree.The angle can be by making column
Convex out produces a part for main body 17 at a certain angle, as shown in attached drawing 13B and 13C.Raised 17A and column main body 17
Intersect or whole protrusion 17A can be flexible or deformable in itself, and can be by the other parts with column main body 17 not
Same material is formed.Alternatively, column main body 17 can keep cylinder substantially, there is the top " cut " at a certain angle.
Sleeve assembly 94 can include one or more binding clasps 117, for engaging and separating sleeve 94 with cylinder 14.
Binding clasp 117 can extend at a certain angle from the collar end 119 of the sleeve in 91 distal side of connector, for by " clamping "
When, leverage is provided to binding clasp 117, therefore the lantern ring 119 of sleeve is deformed away from cylinder 14 in order to discharge.Set
Barrel chamber body 118 can be limited by sleeve 94, to allow sleeve 94 to deform when clamping.For example, as shown in attached drawing 13D, sleeve
Cavity 118 extends through the flange portion 118 of sleeve 94 and is horizontally located at the lower section of flange portion 118, so as to when binding clasp 117
The left-half or right half part for allowing flange 118 when being jammed deform.Extruding includes individually or simultaneously pressing from both sides in one or more
Apply pressure on tight device 117 so that binding clasp 117 is bent towards sleeve 94, is thus lifted the flange pearl 130 of flange 119 and is released
Put the barb 132 of cylinder 14.
Attached drawing 14A-14D is shown clamps the sleeve for locking 120 according to having for one or more embodiments disclosed herein
Component 94.Clamp lock 120 can include two fixture extensions 121.First fixture extension 121A can limit the first fixture
Pier 122A and the second fixture extension 121B can limit the second fixture pier 122B.One or two fixture pier 122 can wrap
A fixture ridge 123 is included, for allowing to engage with clamping the locking of pier 122 when extension 121 is clamped together.Once engagement,
Fixture pier 122 can then be clamped and disengaged.In one embodiment, extension 121 is clipped together flange pearl 130 and column
Body 14 engages, and cylinder 14 is secured in position.Column 14 can limit locator 132（On the downside of cylinder, away from nose bonding part
16 kick）, for the further fixed cylinder 14 when locator 132 is engaged with the location hole 134 defined by sleeve 94
Position and the rotation for resisting cylinder 14.
In certain embodiments, breathe component 10, nasal assembly 12, face shield assembly 20 and/or its any component can be into
One step includes being used for the oral-cavity device fastener 70 for engaging the oral-cavity device 9 engaged with patient's oral area.Such as, but not limited to, patient
Can have the preposition clamping plate of mouth guard, lower jaw that can be used in combination with breathing component 10, nasal assembly 12 and/or face shield assembly 20 or
Some other oral-cavity devices 9.Oral-cavity device fastener 70 can be optionally by breathing component 10, nasal assembly 12 and/or face
Cover 10 is joined to oral-cavity device 9, for stablizing the position of breathing component 10, nasal assembly 12 and/or mask 10 relative to patient 1
Put.
In one or more embodiments, breathing component 10 or its any component can be used as short-period used product to provide,
So that whole system is dropped and replaces after predetermined use time.For example, breathing component 10 can be configured as three
The use product of a month so that patient's every three months receives a new breathing component 10.In one embodiment, cylinder 14,
Anti-skidding component 80 of ordering can be disposable products.Patient can install new adhesive pad 42 and sheet material 30 after each.
Although the preferred embodiment for having been combined each attached drawing describes embodiment, it should be understood that, it can make
With other similar embodiments, or it can modify and add to described embodiment for performing identical function
Without departing from the function.Therefore, the disclosed embodiments should not necessarily be limited by any single embodiment, but should be according to appended right
It is required that explained on width and scope.
Claims (20)
1. component is breathed, including：
Engaged with least one connector and with hose or the pedestal of fluid fluid communication, with allow at least one connection
Gas circulation between device, pedestal and hose or fluid source；
A pair of of the sleeve engaged with least one connector；
A pair of columns, each cylinder is optionally engaged with least one sleeve in a pair of of sleeve, wherein each cylinder includes：
The flange of the opening passed through is limited, the opening is connected with each corresponding sleeve fluid in a pair of of sleeve；
Adhere to each flange and be arranged to sealingly engage the adhesive in patient nostril.
2. breathing component according to claim 1, it is characterised in that described adhesive is pressure sensitive material.
3. breathing component according to claim 1, it is characterised in that described adhesive includes foam.
4. breathing component according to claim 1, it is characterised in that the breathing component is no mask and without band.
5. breathing component according to claim 1, it is characterised in that the pedestal limits two and is used to engage two connections
The opening of device.
6. breathing component according to claim 1, it is characterised in that the pedestal limits four and is used to engage two connections
The opening of device and two caps.
7. breathing component according to claim 1, it is characterised in that the flange of cylinder is relative to the column master limited by cylinder
Body is at an angle of, and engages at least one in a pair of of sleeve each column main selectivity.
8. the breathing component according to claim 5 or 6, it is characterised in that the connector, which defines, is located at least in two
Concave surface between opening, for providing the path to patient.
9. breathing component according to claim 1, it is characterised in that further include the venthole for titration fluid.
10. breathing component according to claim 1, it is characterised in that each in a pair of of sleeve is included described in permission
The binding clasp selectively engaged between sleeve and cylinder.
11. breathing component according to claim 1, it is characterised in that each in a pair of of sleeve includes clamp assembly,
To allow selectively engaging between the sleeve and cylinder, wherein, clamp assembly, which limits, can use at least one fixture ridge
Come the two fixture extensions selectively engaged.
12. the breathing component according to claim 10 or 11, it is characterised in that selectively engage including by the barb of cylinder
Engaged with the flange of sleeve.
13. breathing component includes：
Engaged with least one connector and with hose or the pedestal of fluid fluid communication, with allow at least one connection
Gas circulation between device, pedestal and hose or fluid source；
A pair of of the sleeve engaged with least one connector；
A pair of of cleat assembly, each cleat assembly are optionally engaged with least one in a pair of of sleeve, wherein each folder
Plate component includes：
With the clamping plate flange of the sheet material engagement including the adhesive for engaging patient nostril；
With the clamping plate opening of each corresponding sleeve gas connection in a pair of of sleeve；
At least one chock ridge, at least one sleeve ridge of one being selectively engaged in a pair of of sleeve.
14. breathing component according to claim 13, it is characterised in that described adhesive is pressure sensitive material or bag
Containing foam.
15. breathing component according to claim 13, it is characterised in that the breathing component is no mask and without band
's.
16. breathing component according to claim 13, it is characterised in that the pedestal limits two and is used to engage two companies
Connect the opening of device.
17. breathing component according to claim 13, it is characterised in that the pedestal limits four and is used to engage two companies
Connect the opening and two caps of device.
18. breathing component according to claim 13, it is characterised in that when cleat assembly and sleeve engage, clamping plate is convex
Edge is at an angle of relative to sleeve.
19. the breathing component according to claim 16 or 17, it is characterised in that the connector, which defines, is located at least in two
Concave surface between a opening, for providing the path to patient.
20. breathing component according to claim 1, it is characterised in that further include the venthole for titration fluid.
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14/876,099 US10265493B2 (en) | 2011-11-21 | 2015-10-06 | Respiratory assembly |
| US14/876,099 | 2015-10-06 | ||
| US201662495576P | 2016-09-13 | 2016-09-13 | |
| US29577512 | 2016-09-13 | ||
| US29/577,513 | 2016-09-13 | ||
| US29577513 | 2016-09-13 | ||
| US62/495,576 | 2016-09-13 | ||
| US29/577,515 | 2016-09-13 | ||
| US29577515 | 2016-09-13 | ||
| US29/577,512 | 2016-09-13 | ||
| PCT/US2016/055834 WO2017062677A1 (en) | 2015-10-06 | 2016-10-06 | Respiratory assembly |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN108025156A true CN108025156A (en) | 2018-05-11 |
| CN108025156B CN108025156B (en) | 2021-01-15 |
Family
ID=58488453
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201680055181.5A Active CN108025156B (en) | 2015-10-06 | 2016-10-06 | Breathing assembly |
Country Status (8)
| Country | Link |
|---|---|
| JP (1) | JP7040773B2 (en) |
| KR (1) | KR20180056776A (en) |
| CN (1) | CN108025156B (en) |
| AU (1) | AU2016334080B2 (en) |
| BR (1) | BR112018007048B1 (en) |
| CA (1) | CA2999190A1 (en) |
| MX (1) | MX2018004168A (en) |
| WO (1) | WO2017062677A1 (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11207484B2 (en) | 2011-11-21 | 2021-12-28 | Snap Cpap, Llc | Respiratory assembly |
| US10905842B2 (en) | 2011-11-21 | 2021-02-02 | Snap Cpap, Llc | Respiratory assembly |
| US10265493B2 (en) | 2011-11-21 | 2019-04-23 | Snap Cpap, Llc | Respiratory assembly |
| US11511066B2 (en) | 2015-10-06 | 2022-11-29 | Snap Cpap, Llc | Respiratory assembly |
| WO2019046728A1 (en) * | 2017-09-02 | 2019-03-07 | Snap Cpap, Llc | Respiratory assembly |
| WO2019051245A1 (en) | 2017-09-08 | 2019-03-14 | Vapotherm, Inc. | Birfurcated cannula device |
| CN114269411A (en) | 2019-06-28 | 2022-04-01 | 蒸汽热能公司 | Variable geometry cannula |
| AU2020311310A1 (en) | 2019-07-11 | 2022-02-03 | Snap Cpap, Llc | Respiratory assembly and methods of using the same |
| US11878115B2 (en) | 2019-09-26 | 2024-01-23 | Vapotherm, Inc. | Internal cannula mounted nebulizer |
| CA3149952A1 (en) * | 2019-09-30 | 2021-04-08 | Stuart Heatherington | Respiratory assembly with conduit adapter and methods of use |
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2016
- 2016-10-06 WO PCT/US2016/055834 patent/WO2017062677A1/en active Application Filing
- 2016-10-06 JP JP2018518427A patent/JP7040773B2/en active Active
- 2016-10-06 CN CN201680055181.5A patent/CN108025156B/en active Active
- 2016-10-06 MX MX2018004168A patent/MX2018004168A/en unknown
- 2016-10-06 BR BR112018007048-3A patent/BR112018007048B1/en active IP Right Grant
- 2016-10-06 KR KR1020187012876A patent/KR20180056776A/en unknown
- 2016-10-06 AU AU2016334080A patent/AU2016334080B2/en active Active
- 2016-10-06 CA CA2999190A patent/CA2999190A1/en active Pending
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| US6196223B1 (en) * | 1998-04-10 | 2001-03-06 | William A. Belfer | Strapless respiratory facial mask for customizing to the wearer's face |
| WO2007130067A1 (en) * | 2006-05-10 | 2007-11-15 | Respcare, Inc. | Ventilation interface |
| CN101516300A (en) * | 2006-08-04 | 2009-08-26 | Ric投资有限责任公司 | Nasal and oral patient interface |
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| US20130131534A1 (en) * | 2011-11-21 | 2013-05-23 | Stuart Heatherington | Respiratory mask assembly |
Also Published As
| Publication number | Publication date |
|---|---|
| JP7040773B2 (en) | 2022-03-23 |
| AU2016334080B2 (en) | 2021-02-18 |
| KR20180056776A (en) | 2018-05-29 |
| AU2016334080A1 (en) | 2018-04-12 |
| MX2018004168A (en) | 2018-12-10 |
| JP2018530389A (en) | 2018-10-18 |
| BR112018007048B1 (en) | 2022-06-07 |
| WO2017062677A1 (en) | 2017-04-13 |
| CN108025156B (en) | 2021-01-15 |
| CA2999190A1 (en) | 2017-04-13 |
| BR112018007048A2 (en) | 2018-10-23 |
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