CN108014367B

CN108014367B - Quick-acting curing wound protection film and preparation method and device thereof

Info

Publication number: CN108014367B
Application number: CN201711384840.2A
Authority: CN
Inventors: 黄娟; 王建伟; 陆涛
Original assignee: Jinhua Jingdi Medical Supplies Co ltd; Zhejiang Lover Health Science and Technology Development Co Ltd
Current assignee: Jinhua Jingdi Medical Supplies Co ltd; Zhejiang Lover Health Science and Technology Development Co Ltd
Priority date: 2017-12-20
Filing date: 2017-12-20
Publication date: 2023-07-18
Anticipated expiration: 2037-12-20
Also published as: CN108014367A

Abstract

The invention relates to a quick-acting curing wound protection film and a preparation method and a device thereof in the field of medical and health. The method is characterized in that alginate, chitosan oligosaccharide and calcium chloride are adopted as main raw materials, ethanol and distilled water are used for dissolving to prepare two solutions, and the two solutions are sprayed on a wound through a special device. The special device is divided into a left part and a right part, different solutions are respectively filled, and the solutions are sprayed from different nozzles through respective liquid suction pipes. When the medicine is used, the two nozzles spray two solutions at the same time only by pressing the spray head. After the two solutions are mixed, the solution A (alginate) and the solution B (chitosan oligosaccharide and calcium chloride) quickly generate ionic action to form a layer of compact transparent gel film, which has the characteristics of hemostasis, bacteriostasis, whole piece stripping and the like, accelerates healing and relieves the pain of patients during dressing change. The invention has the advantages of easily available raw materials, simple method, convenient device, convenient use and obvious curative effect, and can be widely used for wounds at all parts of human body.

Description

Quick-acting curing wound protection film and preparation method and device thereof

Technical Field

The invention relates to a quick-acting curing wound protection film and a preparation method and a device thereof, belonging to a medical coating material, a preparation method and a device thereof in the field of medical and health.

Background

At present, the body surface wounds, operation incision and burns and scalds of human bodies are treated by adopting measures such as coating disinfection gauze, winding bandages and the like, and because of blood coagulation, gauze is often attached to the wound surface, and wound new granulation is repeatedly damaged when medicine is replaced, so that the wound healing time is prolonged, intolerable pain is sometimes brought to the patient, and the operation of medical staff is also very troublesome. In addition, the traditional gauze dressing material has poor air permeability at the wound, is not easy to use in a large area, and has the defect of easy invasion of bacteria.

Alginate is a natural anionic polysaccharide which can form gel after contacting with wound exudates, and generates high absorption force by forming strong hydrophilic gel, can lock a large amount of water, and is a good cementing material. Meanwhile, the alginate has unique regulation function on metabolism of human bodies, and has the functions of diminishing inflammation, stopping bleeding, resolving masses and the like. Chitosan is the only natural basic polysaccharide discovered so far, has the functions of resisting bacteria and stopping bleeding, and can prevent the formation of fibrin, the proliferation of connective tissue cells and the synthesis of collagen, so that the dementia is minimized after the wound is healed; the chitosan has better antibacterial property after being degraded into chitosan oligosaccharide with low molecular weight. The wound protecting film prepared by adopting the two substances as main raw materials has the advantages of antibiosis, hemostasis and no toxic or side effect.

Disclosure of Invention

The invention aims at solving the problems existing in the prior art, adopts natural polysaccharide as a main raw material, utilizes a nontoxic solvent to prepare A, B two solutions, and sprays the two solutions at a wound through a special device. When the medicine is used, as long as the spray head is pressed, the two spray nozzles spray A, B two solutions at the same time, and the medicine application can be completed, so that the medicine is very convenient to use. After the medicine is used, as A, B solutions are mixed, the solution A (alginate) and the solution B (chitosan oligosaccharide and calcium chloride) quickly generate ion action, a layer of compact transparent gel film is formed on the surface of the substrate, the chitosan oligosaccharide plays an antibacterial role, and calcium ions of wound exudation liquid enable the gel film to be aged continuously, and finally, the gel film can be peeled off in a whole piece, bacteria are not easy to invade into the film, wounds are not easy to infect, healing is accelerated, and the pain of patients during medicine changing is relieved.

The invention discloses a preparation method of a quick-acting curing wound protection film, which adopts alginate, glycerol and distilled water to prepare liquid A through filtration; adding distilled water into chitosan oligosaccharide, calcium chloride and ethanol, and filtering to obtain liquid B; the mass ratio of the liquid A is alginate: glycerol: distilled water=3 to 25: 5-50: 1000; the mass ratio of the liquid B is chitosan oligosaccharide: calcium chloride: ethanol: distilled water=20 to 80: 2-20: 0-700: 300-1000; the solution A and the solution B are sprayed on the substrate through the nozzles through the respective liquid suction pipes at the same time, and the quick-acting curing wound protection film is obtained after curing; the ratio of the spraying quantity of the solution A to the spraying quantity of the solution B is 0.7-2.5:1; the thickness of the quick-acting curing wound protection film is 0.8-1.2mm.

Preferably, the mass ratio of the liquid B is preferably chitosan oligosaccharide: calcium chloride: ethanol: distilled water=50 to 60:3 to 5: 550-650: 350-450.

The invention also discloses the quick-acting curing wound protection film prepared by the preparation method, and the thickness of the quick-acting curing wound protection film is 0.8-1.2mm.

The preparation device of the quick-acting curing wound protection film comprises a detachable mixing chamber, a chamber A and a chamber B which are mutually independent; the liquid suction device is characterized in that the cavity A and the cavity B are identical in structure, a liquid suction pipe is arranged in the cavity A and the cavity B, the mixing chamber is connected to the cavity A and the cavity B in a threaded or fastening mode, a nozzle is arranged on the mixing chamber, two inlets are arranged at the bottom of the mixing chamber, top outlets of the two liquid suction pipes are respectively connected with the two inlets, a one-way valve is arranged at each inlet, and a baffle with adjustable stroke or a check ring with adjustable opening is arranged on the upper portion of the one-way valve.

Preferably, a travel scale is arranged on the baffle with adjustable travel, and an opening scale is arranged on the retainer with adjustable opening.

Preferably, a mixing pipe is arranged in the mixing chamber, the mixing pipe is Y-shaped, two inlets of the mixing pipe are respectively connected with two inlets at the bottom of the mixing chamber, and an outlet of the mixing pipe is connected to the nozzle.

Preferably, a mixing chamber is arranged in the mixing chamber, the mixing chamber is detachably fixed at the bottom of the mixing chamber, the mixing chamber covers two inlets at the bottom of the mixing chamber, and the mixing chamber is connected to the nozzle.

The natural materials adopted by the invention can be extracted from coastal animal and plant products, the coastline of China is wide, and the raw materials are easy to obtain; the preparation method of the quick-acting curing wound protection film is simple; the device is convenient and fast, and is convenient to produce and use. The trial has obvious curative effect, and the wound, the operation suture mouth, the burn and scald surface and the like of all parts of the human body can be used except for deep wounds or wounds with infected inside and is not suitable for spraying.

Drawings

Fig. 1 is a schematic view of a preparation apparatus (mixing tube) of a quick-acting cured wound-protecting film.

Fig. 2 is a schematic view of a preparation apparatus (mixing chamber) of a quick-acting curing wound-protecting film.

In the figure, 1 chamber A,2 chamber B,3 pipettes, 4 baffles or check rings, 5 mixing pipes, 6 nozzles, 7 mixing chambers, 8 push handles and 9 check valves.

Detailed Description

As shown in FIG. 1, the preparation device of the quick-acting curing wound protection film comprises a detachable mixing chamber, a chamber A1 and a chamber B2 which are independent from each other; the liquid suction device is characterized in that the cavity A and the cavity B are identical in structure, a liquid suction pipe 3 is arranged in the cavity A and the cavity B, the mixing chamber is connected to the cavity A and the cavity B in a threaded or fastening mode, a nozzle 6 is arranged on the mixing chamber, two inlets are arranged at the bottom of the mixing chamber, top outlets of the two liquid suction pipes are respectively connected with the two inlets, a one-way valve 9 is arranged at each inlet, a baffle 4 with an adjustable stroke or a retainer ring 4 with an adjustable opening is arranged on the upper portion of the one-way valve, and the nozzle serves as an outlet of the mixing chamber.

The working principle of the invention is that two independent chambers A and B are used for respectively storing liquid A and liquid B, the one-way valve at the inlet of the top of the liquid suction pipe enables the liquid to pass from bottom to top, and the liquid in the mixing chamber is prevented from being mixed into the chamber A or the chamber B; the stroke-adjustable baffle 4 or the opening-adjustable baffle ring 4 is used for adjusting the liquid proportion of the chamber A and the chamber B entering the mixing cavity, namely finally adjusting the ratio of the solution A to the solution B in the ejection quantity, and by pressing the pressing handle 8, some air in the interior is pumped out so that the air pressure in a pipe connected with the spray head is smaller than the internal liquid level pressure, and the liquid is ejected under the action of the pressure.

The nozzle configuration does not affect the operation of the device of the present invention, and can be selected and designed as desired, the principle of operation being the same, and figures 1 and 2 are given as alternative examples only and should not be construed as limiting the invention.

Preferably, a travel scale is arranged on the baffle with adjustable travel, and an opening scale is arranged on the retainer with adjustable opening. The scale can conveniently determine the specific opening of the inlet so as to quantify the ratio of the ejection amounts of the solution A and the solution B.

In one embodiment of the present invention, as shown in fig. 1, a mixing tube is disposed in the mixing chamber, the mixing tube is in a Y-shape, two inlets of the mixing tube are respectively connected to two inlets at the bottom of the mixing chamber, and an outlet of the mixing tube is connected to a nozzle. The liquids are mixed in a mixing tube and ejected from a nozzle. The mixing tube can be replaced and cleaned.

As shown in fig. 2, a mixing chamber is arranged in the mixing chamber, the mixing chamber is detachably fixed at the bottom of the mixing chamber, the mixing chamber covers two inlets at the bottom of the mixing chamber, and the mixing chamber is connected to the nozzle. The liquid is mixed in the mixing chamber and ejected from the nozzle. The mixing chamber is removably mounted (e.g., threaded or snap-fit) for replacement and cleaning. The mixing chamber of the present invention is only a small portion of the upper region of chamber a and chamber B, which requires that liquids a and B pass quickly, avoid gel blocking the tubing due to longer residence times, and require ease of cleaning.

Example 1

Accurately weighing 18g of sodium alginate, 15g of glycerol, adding 1000ml of distilled water to prepare light yellow liquid, forcibly filtering and filling; accurately weighing 60g of chitosan oligosaccharide and 3g of calcium chloride, adding 650ml of ethanol and 350ml of distilled water, forcibly filtering, filling, loading a spray head and sealing. The gel film is solidified after 15 seconds by spraying on a substrate by adopting the device shown in the figure 1, the film has smooth appearance, can be used for wound repair and healing, and the thickness of the quick-acting solidified wound protection film is 1mm.

Example 2

Accurately weighing 15g of sodium alginate, 10g of glycerol, adding 1000ml of distilled water to prepare light yellow liquid, forcibly filtering and filling; accurately weighing 50g of chitosan oligosaccharide and 5g of calcium chloride, adding 600ml of ethanol and 400ml of distilled water, forcibly filtering, filling, loading a spray head and sealing. The gel film is solidified after 15 seconds by spraying on the substrate by adopting the device of the attached figure 1, the film has smooth appearance, and the thickness of the quick-acting solidified wound protection film is 0.8mm, so that the quick-acting solidified wound protection film can be used for wound repair and healing.

Example 3

Accurately weighing 20g of sodium alginate, 25g of glycerol, adding 1000ml of distilled water to prepare light yellow liquid, forcibly filtering and filling; accurately weighing 40g of chitosan oligosaccharide and 15g of calcium chloride, adding 450ml of ethanol and 550ml of distilled water, forcibly filtering, filling, loading a spray head and sealing. The gel film is solidified after 30 seconds by spraying on a substrate by adopting the device shown in the figure 2, the film has smooth appearance, and the thickness of the quick-acting solidified wound protection film is 1.2mm, so that the quick-acting solidified wound protection film can be used for wound repair and healing.

Example 4

Accurately weighing 25g of sodium alginate, 30g of glycerol, adding 1000ml of distilled water to prepare light yellow liquid, forcibly filtering and filling; accurately weighing 70g of chitosan oligosaccharide and 20g of calcium chloride, adding 350ml of ethanol and 650ml of distilled water, forcibly filtering, filling, loading a spray head and sealing. The gel film was cured after 45 seconds by spraying on the wound with the device of fig. 2, and the film appearance was smooth. The experiment also proves that the scheme of the invention can directly spray the wound in situ to prepare the quick-acting curing wound protection film.

The wound protection film has good antibacterial effect, and the experimental result is as follows:

note that: "+" indicates colony growth and "-" indicates colony growth.

Finally, it should also be noted that the above list is merely a specific example of the invention. Obviously, the invention is not limited to the above embodiment examples, but many variations are possible. All modifications directly derived or suggested to one skilled in the art from the present disclosure should be considered as being within the scope of the present invention.

Claims

1. The preparation method of the quick-acting curing wound protection film is based on a preparation device, and the preparation device comprises a detachable mixing chamber, a chamber A and a chamber B which are mutually independent; the device comprises a chamber A, a chamber B, a mixing chamber, a check valve, a baffle plate with adjustable stroke and a check ring with adjustable opening, wherein the chamber A and the chamber B have the same structure, the chamber A and the chamber B are internally provided with a liquid suction pipe, the mixing chamber is connected to the chamber A and the chamber B in a threaded or fastening connection mode, a nozzle is arranged on the mixing chamber, two inlets are arranged at the bottom of the mixing chamber, top outlets of the two liquid suction pipes are respectively connected with the two inlets, a check valve is arranged at each inlet, and the upper part of the check valve is provided with the baffle plate with adjustable stroke or the check ring with adjustable opening;

the mixing chamber is internally provided with a mixing pipe which is Y-shaped, two inlets of the mixing pipe are respectively connected with two inlets at the bottom of the mixing chamber, and an outlet of the mixing pipe is connected to the nozzle; the mixing chamber is internally provided with a mixing cavity, the mixing cavity is detachably fixed at the bottom of the mixing chamber, the mixing cavity covers two inlets at the bottom of the mixing chamber, and the mixing cavity is connected to the nozzle;

the baffle with adjustable travel is provided with a travel scale, and the retainer ring with adjustable opening is provided with an opening scale;

the preparation method is characterized by comprising the following steps:

adding distilled water into alginate and glycerol, and filtering to obtain liquid A; adding distilled water into chitosan oligosaccharide, calcium chloride and ethanol, and filtering to obtain liquid B; the mass ratio of the liquid A is alginate: glycerol: distilled water=3 to 25: 5-50: 1000; the mass ratio of the liquid B is chitosan oligosaccharide: calcium chloride: ethanol: distilled water=20 to 80: 2-20: 0-700: 300-1000 parts; the two independent chambers A and B are used for respectively storing the liquid A and the liquid B, and the liquid can only pass through the one-way valve at the inlet of the top of the liquid suction pipe from bottom to top, so that the liquid in the mixing chamber is prevented from being mixed into the chamber A or the chamber B; the stroke-adjustable baffle or the opening-adjustable retainer ring is used for adjusting the liquid proportion of the chamber A and the chamber B entering the mixing chamber, namely finally adjusting the ratio of the spraying quantity of the solution A to the spraying quantity of the solution B;

the solution A and the solution B are sprayed on the substrate through the nozzles through the respective liquid suction pipes at the same time, and the quick-acting curing wound protection film is obtained after curing; the ratio of the spraying amount of the solution A to the spraying amount of the solution B is 0.7-2.5:1; the thickness of the quick-acting curing wound protection film is 0.8-1.2mm.

2. The preparation method of claim 1, wherein the liquid B comprises the following components in percentage by mass: calcium chloride: ethanol: distilled water=50 to 60: 3-5: 550-650: 350-450.

3. A quick-setting wound-protecting film prepared by the preparation method of claim 1.