CN108008141B - Microplate sample adding device and microplate sample adding system - Google Patents
Microplate sample adding device and microplate sample adding system Download PDFInfo
- Publication number
- CN108008141B CN108008141B CN201711228125.XA CN201711228125A CN108008141B CN 108008141 B CN108008141 B CN 108008141B CN 201711228125 A CN201711228125 A CN 201711228125A CN 108008141 B CN108008141 B CN 108008141B
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- microplate
- plate
- sample adding
- clamping groove
- notch
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- 239000011148 porous material Substances 0.000 claims abstract description 11
- 239000011810 insulating material Substances 0.000 claims description 3
- 238000000034 method Methods 0.000 abstract description 8
- 230000000694 effects Effects 0.000 description 3
- 230000008014 freezing Effects 0.000 description 3
- 238000007710 freezing Methods 0.000 description 3
- 239000011324 bead Substances 0.000 description 2
- 238000004146 energy storage Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 125000006850 spacer group Chemical group 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 1
- 239000012295 chemical reaction liquid Substances 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
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- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
The invention discloses a microplate sample adding device and a microplate sample adding system, and particularly discloses a microplate sample adding device which comprises a clamping groove and an indicating plate; the clamping groove is used for accommodating a micro-pore plate; the indication board comprises a board body and a scale part, wherein the scale part is used for marking micropores on the micropore board; the side wall of the clamping groove is provided with a notch for the push-pull movement of the plate body of the indication plate, and a part of the plate body extends into the clamping groove from the notch. When the microplate sample adding device is used, the microplate is placed into the clamping groove during sample adding, the indicating plate is pushed forward to enable the staff gauge to be positioned on the corresponding row of the microplate, the required row and the corresponding column number can be indicated easily, and sample adding errors are reduced; the microplate sample adding device is also provided with the ice storage chamber, so that the microplate sample adding device can be ensured to be in a low-temperature environment in the sample adding process.
Description
Technical Field
The invention relates to the field of experimental instruments, in particular to a microplate sample adding device and a microplate sample adding system.
Background
When the sample is applied to a PCR microplate, a 96-well plate or 384-well plate is generally adopted, and the number of the wells is large, the space between the wells is very small, and no obvious separation mark exists between the wells, so that the situation that the sample is mixed or omitted in a row or column mode often occurs when the sample is applied by a pipette, and the experimental result is abnormal. Therefore, the spirit of operators is required to be concentrated in the sample adding process, and the spirit pressure of the operators is greatly increased.
Meanwhile, the situation that different reaction liquids need to be added to one 96-well plate or 384-well plate in different areas can be met in the experiment, and under the irregular sample adding condition, the automatic sample adding arm system is difficult to operate, and errors are easier to occur under the manual sample adding condition.
Disclosure of Invention
The invention aims to solve the problems of easy error and low working efficiency in the existing sample adding process. In addition, a low temperature environment is often required in the microplate loading process, and thus a microplate loading device capable of providing a low temperature environment is required.
In order to achieve the above object, a first aspect of the present invention provides a microplate loading device, which includes a clamping groove and an indicator plate; the clamping groove is used for accommodating a micro-pore plate; the indication board comprises a board body and a scale part, wherein the scale part is used for marking micropores on the micropore board; the side wall of the clamping groove is provided with a notch for the push-pull movement of the plate body of the indication plate, and a part of the plate body extends into the clamping groove from the notch.
Further, the clamping groove comprises an ice storage chamber, and when the micro-pore plate is positioned in the clamping groove, the micro-pore plate is positioned above the ice storage chamber. During use, ice cubes can be placed in the ice storage chamber for providing a low temperature environment.
Further, the ice storage compartment outer wall is made of a heat insulating material.
Further, the notch comprises a pressing strip and an elastic component (such as a spring), the elastic component is positioned between the top surface of the notch and the pressing strip, a chute is arranged on the vertical wall of the notch, two ends of the pressing strip are provided with protruding parts, the protruding parts are positioned in the chute, and the pressing strip can move up and down along the chute; the indicator plate is located between the bead and the bottom surface of the slot.
Further, equidistant grooves are formed in the upper surface of the indication plate, and protrusions matched with the grooves are arranged on the bottom surface of the pressing strip.
Further, a baffle is further arranged at the outer side edge of the indication plate, the baffle is perpendicular to the indication plate, the thickness of the baffle is larger than the height of the notch, and/or the length of the baffle is larger than the length of the notch.
Further, the scale portion includes a first identification region and a second identification region, the first identification region configured to identify microwells of a 96-well plate; the second identification region is configured to identify a microwell of a 384 well plate.
Further, the cross section of the scale part is in a positive trapezoid shape.
Further, the cross section of the scale part is in a regular trapezoid shape, and the front end of the scale part forms an inclined plane; the scale part is connected with the plate body of the indication plate in a folding way; the bottom surface of scale portion is equipped with first sign district, the inclined plane of scale portion is equipped with the second sign district. The scale portion has a folded state and an extended state.
In another preferred embodiment, the scale part comprises a containing cavity and a marking rod, the cross section of the marking rod is in a regular trapezoid shape, and the front end of the marking rod forms an inclined plane; the identification rod can be accommodated in the accommodating cavity; the surface of accomodate chamber upper portion is equipped with first sign district, the inclined plane of sign pole is equipped with the second sign district.
A second aspect of the present invention provides a microplate loading system comprising a microplate loading device provided in the first aspect of the present invention, and a microplate assembly; the microplate assembly comprises one or more microplates.
In another preferred embodiment, the microplate assembly comprises one or more 96-well microplates.
In another preferred embodiment, the microplate assembly comprises one or more 384 well microplates.
In another preferred embodiment, the microplate set comprises at least one 96 well microplate and at least one 384 well microplate.
Technical effects
When the microplate sample adding device is used, the microplate is placed into the clamping groove during sample adding, the indicating plate is pushed forward to enable the staff gauge to be positioned on the corresponding row of the microplate, the required row and the corresponding column number can be indicated easily, and sample adding errors are reduced; the microplate sample adding device is also provided with the ice storage chamber, so that the microplate sample adding device can be ensured to be in a low-temperature environment in the sample adding process.
The conception, specific structure, and technical effects of the present invention will be further described with reference to the accompanying drawings to fully understand the objects, features, and effects of the present invention.
Drawings
FIG. 1 is a schematic plan view of a microplate loading device in accordance with a preferred embodiment of the present invention.
FIG. 2 is a schematic cross-sectional view of a microplate loading device in accordance with a preferred embodiment of the present invention.
FIG. 3 is a schematic plan view of a microplate loading device in accordance with a preferred embodiment of the present invention.
Fig. 4 is a partially enlarged schematic view of the scale section, showing a folded state of the scale section.
Fig. 5 is a partially enlarged schematic view of the scale section, showing the scale section in an extended state.
FIG. 6 is a schematic view of a partially enlarged scale portion of another preferred embodiment.
FIG. 7 is a schematic cross-sectional view of a microplate loading device in accordance with another preferred embodiment.
Detailed Description
Example 1
As shown in fig. 1, 2 and 3, the present embodiment provides a microplate loading device, which includes a clamping groove 1 and an indicator plate 2; the clamping groove 1 is used for accommodating a micro-pore plate 01; the indication board 2 comprises a board body 22 and a scale part 21, wherein the scale part 21 is used for marking micropores on the micropore board 01; the side wall of the clamping groove 1 is provided with a notch 11 for the drawing and moving of the plate body 22 of the indication plate 2, and a part of the plate body 22 stretches into the clamping groove 1 from the notch 11.
The clamping groove 1 comprises an ice storage chamber 12, and when the micro-pore plate 01 is positioned in the clamping groove 1, the micro-pore plate 01 is positioned above the ice storage chamber 12. In use, ice cubes can be placed in the ice storage chamber 12 for providing a low temperature environment. It is also possible to put water into the ice storage chamber 12 and then freeze it to obtain ice cubes before use. The outer wall of the ice storage chamber 12 is made of a heat insulating material. No spacer is arranged between the ice storage chamber 12 and the micro-pore plate 01, namely the micro-pore plate 01 is directly arranged on the ice surface; thermally conductive spacers may also be provided.
The ice storage chamber 12 may be independent of the card slot 1, i.e., the ice storage chamber 12 may be separated from the card slot 1; the ice storage chamber 12 may also be part of the body of the card slot 1.
As shown in fig. 2, the notch 11 includes a pressing strip 13 and an elastic component 14, the elastic component 14 is located between the top surface of the notch 11 and the pressing strip 13, a chute is arranged on the vertical wall of the notch 11, the chute is vertically arranged, two ends of the pressing strip 13 are provided with protruding parts 131, the protruding parts 131 are located in the chute, and the pressing strip 13 can move up and down along the chute; the indicator plate 2 is located between the bead 13 and the bottom surface of the slot 11. The pressing bar 13 can provide a force pressing down the indicator plate 2 under the action of the elastic member 14, so that the indicator plate 2 is closely attached to the microplate 01. The notch 11 has a height that allows the indicator plate 2 to move up and down. In some cases, the ice surface in the ice storage chamber is too high, which results in too high a position of the microplate 01, and if the indicator plate 2 cannot move up and down, the indicator plate 2 cannot cover the microplate 01. In the present embodiment, the indicator plate 2 is movable up and down, so that microplates 01 having different heights can be used.
As shown in fig. 1 and 2, in order to facilitate adjusting the position of the indicator plate 2, in this embodiment, equidistant grooves 221 are provided on the upper surface of the plate body 22 of the indicator plate 2, and protrusions 132 matching with the grooves 221 are provided on the bottom surface of the pressing bar 13. The recess 221 is a hemispherical recess, and the protrusion 132 is a hemispherical protrusion accordingly. The distance between adjacent grooves 221 may be equal to the distance between adjacent microwells on a 384 well microwell plate. When the indication board 2 is pushed and pulled, the indication board 2 can be positioned conveniently.
The outer side edge of the indication board 2 is further provided with a baffle plate 23, the baffle plate 23 is perpendicular to the indication board 2, the thickness of the baffle plate 23 is greater than the height of the notch 11, and/or the length of the baffle plate 23 is greater than the length of the notch 11. The baffle 23 may act as a force application point, and the indicator plate 2 may not fully enter the card slot 1 because the baffle 23 is higher and/or longer than the slot 11.
The scale section 21 includes a first identification region 211 and a second identification region 212, the first identification region 211 being provided for identifying microwells of a 96-well microwell plate; the second identification region 212 is configured to identify the microwells of a 384 well microwell plate. The first identification area 211 identifies a column number on a 96-well microplate; the second identification region 212 identifies a column number on a 384 well microplate.
As shown in fig. 4 and 5, the cross section of the scale portion 21 is in a regular trapezoid shape, and the front end forms an inclined plane; the scale part 21 is connected with the plate body 22 of the indication plate 2 in a folding way; the first identification area 211 is provided on the bottom surface of the scale portion 21, and the second identification area 212 is provided on the inclined surface of the scale portion 21. The scale portion 21 has a folded state (fig. 4) and an extended state (fig. 5).
A set of microplate sample adding device is designed aiming at the problems encountered in the PCR sample adding process, and can conveniently, rapidly and accurately add samples. Meanwhile, the PCR sample addition usually needs a low-temperature environment, and the microplate sample addition device of the embodiment is provided with an ice storage chamber, so that the solution in the sample addition process is ensured to be in the low-temperature environment.
The working principle is as follows: the sample adding shell is designed into a drawing type structure, the small drawer is designed into a freezing type energy storage ice box, before sample adding, the ice box-20 is frozen for storage, and the freezing type energy storage ice box is inserted into the porous sample adding recorder during sample adding, so that a low-temperature environment of about 1h can be maintained, and the requirement of the PCR sample adding process on low temperature is met.
Meanwhile, a plastic narrow strip capable of sliding is arranged in the row direction of the PCR plate on the sample adding shell, corresponding numbers, such as 96-well plates, are respectively arranged on two sides of the plastic narrow strip according to the number of 384-well or 96-well plate columns, and 1-12, 384-well plates and 1-24 are arranged. When the plastic narrow strip is added, the plastic narrow strip is pushed to the corresponding row, the required row and the corresponding column number can be easily indicated, and the sample adding error is reduced.
Example 2
As shown in fig. 6, the basic structure of the microplate loading device provided in this embodiment is the same as that of embodiment 1, and is different in that the scale portion 21 includes a housing cavity 213 and a marking rod 214, the cross section of the marking rod 214 is in a regular trapezoid shape, and the front end forms an inclined plane. The identification rod 214 can be accommodated in the accommodating cavity 213; the surface of the upper part of the accommodating cavity 213 is provided with the first identification area 211, and the inclined surface of the identification rod is provided with the second identification area 212. The position of the identification rod 214 can be adjusted by a bolt 215.
Example 3
As shown in fig. 7, the basic structure of the microplate loading device provided in this embodiment is the same as that of embodiment 1, and is different in that the ice storage chamber 12 is independent from the clamping groove 1, the bottom of the clamping groove 1 is opened, and the ice storage chamber 12 can be sleeved in the clamping groove 1. The inner wall of the clamping groove 1 is provided with a supporting arm for supporting the micro-pore plate 01.
In other embodiments, the side wall of the clamping groove 1 is open, and the ice storage chamber 12 enters and exits the clamping groove 1 in a push-pull mode.
The independent ice storage chamber 12 can make ice more conveniently, and the whole microplate loading device does not need to be put into a refrigerator for freezing.
The foregoing describes in detail preferred embodiments of the present invention. It should be understood that numerous modifications and variations can be made in accordance with the concepts of the invention by one of ordinary skill in the art without undue burden. Therefore, all technical solutions which can be obtained by logic analysis, reasoning or limited experiments based on the prior art by the person skilled in the art according to the inventive concept shall be within the scope of protection defined by the claims.
Claims (9)
1. The microplate sample adding device is characterized by comprising a clamping groove and an indication plate; the clamping groove is used for accommodating a micro-pore plate; the indication board comprises a board body and a scale part, wherein the scale part is used for marking micropores on the micropore board; the side wall of the clamping groove is provided with a notch for the push-pull movement of the plate body of the indication plate, and a part of the plate body extends into the clamping groove from the notch; the scale part comprises a first identification area and a second identification area, and the first identification area is used for identifying micropores of the 96-hole microporous plate; the second identification region is configured to identify a microwell of a 384 well microwell plate; the notch comprises a pressing strip and an elastic part, the elastic part is positioned between the top surface of the notch and the pressing strip, a chute is arranged on the vertical wall of the notch, two ends of the pressing strip are provided with protruding parts, the protruding parts are positioned in the chute, and the pressing strip can move up and down along the chute; the indication plate is positioned between the pressing strip and the bottom surface of the notch; the upper surface of the indicating plate is provided with equidistant grooves, and the bottom surface of the pressing strip is provided with protrusions matched with the grooves.
2. The microplate loading device of claim 1, wherein the card slot comprises an ice storage compartment, the microplate being located above the ice storage compartment when the microplate is located in the card slot.
3. The microplate loading device of claim 2, wherein the ice storage compartment outer wall is made of a thermally insulating material.
4. The microplate loading device of claim 1, wherein the resilient member is a spring.
5. The microplate loading device of claim 1, wherein the outer edge of the indicator plate is further provided with a baffle, the baffle is perpendicular to the indicator plate, the thickness of the baffle is greater than the height of the slot, and/or the length of the baffle is greater than the length of the slot.
6. The microplate loading device of claim 1, wherein the scale portion has a cross-section that is positively trapezoidal.
7. The microplate loading device of claim 1, wherein the scale portion has a regular trapezoid cross section, and a front end thereof forms an inclined plane; the scale part is connected with the plate body of the indication plate in a folding way; the bottom surface of the scale part is provided with the first identification area, and the inclined surface of the scale part is provided with the second identification area; or alternatively
The scale part comprises a containing cavity and a marking rod, the cross section of the marking rod is in a regular trapezoid shape, and the front end of the marking rod forms an inclined plane; the identification rod can be accommodated in the accommodating cavity; the surface of accomodate chamber upper portion is equipped with first sign district, the inclined plane of sign pole is equipped with the second sign district.
8. A microplate loading system comprising the microplate loading device of claim 1, and a microplate assembly; the microplate assembly comprises one or more microplates.
9. The microplate loading system of claim 8, wherein the microplate assembly comprises at least one 96-well microplate and at least one 384-well microplate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711228125.XA CN108008141B (en) | 2017-11-29 | 2017-11-29 | Microplate sample adding device and microplate sample adding system |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711228125.XA CN108008141B (en) | 2017-11-29 | 2017-11-29 | Microplate sample adding device and microplate sample adding system |
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| CN108008141A CN108008141A (en) | 2018-05-08 |
| CN108008141B true CN108008141B (en) | 2024-04-12 |
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| CN201711228125.XA Active CN108008141B (en) | 2017-11-29 | 2017-11-29 | Microplate sample adding device and microplate sample adding system |
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110317714A (en) * | 2019-08-14 | 2019-10-11 | 北京市中医研究所 | The PCR microwell plate adapter of low temperature tape light |
| CN112500986A (en) * | 2020-12-09 | 2021-03-16 | 佛山市第一人民医院（中山大学附属佛山医院） | Nucleic acid extraction operation indicator board |
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| CN108008141A (en) | 2018-05-08 |
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