CN107998464A - A kind of nasal septum stent - Google Patents
A kind of nasal septum stent Download PDFInfo
- Publication number
- CN107998464A CN107998464A CN201711222373.3A CN201711222373A CN107998464A CN 107998464 A CN107998464 A CN 107998464A CN 201711222373 A CN201711222373 A CN 201711222373A CN 107998464 A CN107998464 A CN 107998464A
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- Prior art keywords
- nasal septum
- stent
- coating
- polymer
- stent according
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/02—Methods for coating medical devices
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention discloses a kind of nasal septum stent, belong to medical field, the nasal septum stent includes nasal septum rack body and antimicrobial coating, the antimicrobial coating is located at the surface of nasal septum rack body, the thickness of the antimicrobial coating is 0.01mm 1mm, the antimicrobial coating is a kind of polymer coating, and the polymer coating is a kind of makrolon multi-monomer grafting polymer, and the grafted monomers include containing phenyl ring or pyridine ring unsaturated silane and acrylonitrile monemer.
Description
Technical field
The present invention relates to area of medical devices, a kind of specifically nasal septum stent.
Background technology
Deviation of nasal septum, is also deviation of nasal septum, refers to deviated nasal septum from center line to side or two bendings or local shape
Into projection, cause nose dysfunction or produce symptom, but the honest person of nasal septum is very few, such as nonfunctional obstacle, shouldn't handle.
The common cause of disease includes：Wound, dysplasia, the compressing of nose intracavitary neoplasm foreign matter etc..Cardinal symptom is：Alternately or continue
Property nasal obstruction, headache, nosebleed and rhinorrhea etc..In fact the completely honest person of nasal septum is very few, often there is different degrees of deflection, and
Above-mentioned various forms can exist at the same time.Deviation of nasal septum such as nonfunctional obstacle is known as " physiological deviation of nasal septum "；As occurred
Dysfunction, diorthosis for deflection of nasal septum art can be used to deviation of nasal septum.
When nasal septum is corrected, it is often necessary to use nasal septum stenter to implant, nasal septum stent is direct contact people
Body wound, will cause patient to infect if sterilization is not thorough, seriously can be fatal, and the cleaning of the nasal septum stent is one and asks
Topic, the nasal septum rack surface being not easily cleaned once are infected with drug-resistant bacteria, patient will be made to face the risk of secondary infection.
The content of the invention
It is an object of the invention to solve the above-mentioned problems, disclose a kind of nasal septum stent, the nasal septal branch
Frame includes nasal septum rack body and antimicrobial coating, and the antimicrobial coating is located at the surface of nasal septum rack body, described
The thickness of antimicrobial coating is 0.01mm-1mm, and the antimicrobial coating is a kind of polymer coating, the polymer coating
It is a kind of makrolon multi-monomer grafting polymer, the grafted monomers include containing phenyl ring or pyridine ring unsaturated silane
And acrylonitrile monemer.
As an improvement, the unsaturated silane monomer is selected from：Triple phenoxyl vinyl silanes, 3- chloropropyl dimethyl second
Alkenyl silanes, triphenyl vinyl silane, 3,5-dimethylphenyl vinyl silanes, dimethyl (2- pyridine radicals) vinyl silanes.
As an improvement, the polymer and grafted monomers parts by weight of raw materials is as follows：100 parts of makrolon, unsaturated silicon
5-20 parts of alkane monomer, 5-20 parts of acrylonitrile monemer.
As an improvement, the preparation method of the polymer coating is as follows：
Step A：Unsaturated silane, acrylonitrile are uniformly mixed；
Step B:Makrolon is melted in rheometer；
Step C：Mixture and initiator after step A are added in rheometer, react 5 min -10min..
As an improvement, the initiator is selected from benzoyl peroxide, lauroyl peroxide, isopropyl benzene hydroperoxide, uncle
Butylhydroperoxide, cumyl peroxide.
As an improvement, the initiator is benzoyl peroxide and the mixture of cumyl peroxide, molar ratio is
1:（0.7-1.5）.
As an improvement, the melting time of the step B is 1-5min.
In contrast experiment, inventor can trigger infection and the stronger Pseudomonas aeruginosa of inflammation, drug resistance and golden yellow Portugal
Grape coccus is transplanted to the nasal septum stent of this polymer coating and common nasal septum stent respectively.Carried out after after a while
Test show that the pathogen residual quantity of new polymers coating surface just corresponds to common nasal septum stent surface bacteria quantity
Thousands of to hundreds of a ten thousandths.
Embodiment
With reference to the present invention is described in detail.
In order to make the purpose , technical scheme and advantage of the present invention be clearer, with reference to embodiments, to the present invention
It is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, it is not used to
Limit the present invention.
Specific embodiment 1：A kind of nasal septum stent, the nasal septum stent includes nasal septum rack body and antibacterial applies
Layer, the antimicrobial coating are located at the surface of nasal septum rack body, and the thickness of the antimicrobial coating is 0.01mm-1mm, institute
The antimicrobial coating stated is a kind of polymer coating, and the polymer coating is a kind of makrolon multi-monomer grafting polymerization
Thing, the grafted monomers include dimethyl (2- pyridine radicals) vinyl silanes and acrylonitrile monemer thing coating.
The polymer and grafted monomers parts by weight of raw materials is as follows：100 parts of makrolon, dimethyl (2- pyridine radicals) second
5 parts of alkenyl silanes monomer, 20 parts of acrylonitrile monemer.
The preparation method of polymer coating is as follows：
Step A：Unsaturated silane, acrylonitrile are uniformly mixed；
Step B:Makrolon is melted in rheometer, melting time 5min；
Step C：Mixture and initiator after step A are added in rheometer, and initiator is the 0.1% of makrolon weight,
React 5 min；
The initiator is the mixture of benzoyl peroxide and cumyl peroxide, molar ratio 1:0.7.
Embodiment 1 and common nasal septum stent are subjected to contrast discovery, the bacterium of embodiment 1 remains common nasal septum stent
Ten a ten thousandths to 3/100000ths.
Claims (7)
1. a kind of nasal septum stent, the nasal septum stent includes nasal septum rack body and antimicrobial coating, the antibacterial
Coating is located at the surface of nasal septum rack body, and the thickness of the antimicrobial coating is 0.01mm-1mm, the antimicrobial coating
It is a kind of polymer coating, the polymer coating is a kind of makrolon multi-monomer grafting polymer, the grafting
Monomer includes containing phenyl ring or pyridine ring unsaturated silane and acrylonitrile monemer.
2. nasal septum stent according to claim 1, it is characterised in that the unsaturated silane monomer is selected from：Triphen
Ethoxy ethylene base silane, 3- chloropropyl dimethylvinylsiloxies base silane, triphenyl vinyl silane, 3,5-dimethylphenyl vinyl silicon
Alkane, dimethyl (2- pyridine radicals) vinyl silanes.
3. nasal septum stent according to claim 2, it is characterised in that the polymer and grafted monomers raw material weight
Part is as follows：100 parts of makrolon, 5-20 parts of unsaturated silane monomer, 5-20 parts of acrylonitrile monemer.
4. nasal septum stent according to claim 3, it is characterised in that the preparation method of the polymer coating is such as
Under：
Step A：Unsaturated silane, acrylonitrile are uniformly mixed；
Step B:Makrolon is melted in rheometer；
Step C：Mixture and initiator after step A are added in rheometer, react 5 min -10min.
5. nasal septum stent according to claim 4, it is characterised in that the initiator be selected from benzoyl peroxide,
Lauroyl peroxide, isopropyl benzene hydroperoxide, tert-butyl hydroperoxide, cumyl peroxide.
6. nasal septum stent according to claim 5, it is characterised in that the initiator is benzoyl peroxide and mistake
Aoxidize the mixture of diisopropylbenzene (DIPB), molar ratio 1:（0.7-1.5）.
7. nasal septum stent according to claim 6, it is characterised in that the melting time of the step B is 1-5min.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711222373.3A CN107998464A (en) | 2017-11-29 | 2017-11-29 | A kind of nasal septum stent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711222373.3A CN107998464A (en) | 2017-11-29 | 2017-11-29 | A kind of nasal septum stent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107998464A true CN107998464A (en) | 2018-05-08 |
Family
ID=62054701
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711222373.3A Withdrawn CN107998464A (en) | 2017-11-29 | 2017-11-29 | A kind of nasal septum stent |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107998464A (en) |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1596844A (en) * | 2004-09-11 | 2005-03-23 | 陈立财 | Artificial nose body for nose raising operation nose artificial body moulding material and moulding knife |
| CN101496813A (en) * | 2008-02-03 | 2009-08-05 | 吴昊 | Anti-hyperblastosis (vascular restenosis) composition and application method |
| CN201840502U (en) * | 2010-08-27 | 2011-05-25 | 陈学东 | Device for fixation and compression hemostasis after nasal septum surgery |
| CN102151339A (en) * | 2011-03-23 | 2011-08-17 | 浙江大学 | Preparation method of silver-carried multilayer film coating biliary tract support frame |
| CN102316826A (en) * | 2007-06-11 | 2012-01-11 | 任基标 | Aiding apparatus for nasal cartilage strut in nasal tip surgery |
| CN103108895A (en) * | 2010-09-17 | 2013-05-15 | 沙伯基础创新塑料知识产权有限公司 | Polycarbonate graft copolymers |
| CN103551055A (en) * | 2013-11-01 | 2014-02-05 | 中国海诚工程科技股份有限公司 | Modifying method of cellulose acetate filtration membrane |
| CN104905893A (en) * | 2015-05-18 | 2015-09-16 | 江苏创发生物科技有限公司 | Anti-infection titanium tantalum bone implantation object and preparing method thereof |
| CN106632864A (en) * | 2016-12-05 | 2017-05-10 | 彭州市运达知识产权服务有限公司 | HDPE multi-monomer graft polymer and preparation method thereof |
-
2017
- 2017-11-29 CN CN201711222373.3A patent/CN107998464A/en not_active Withdrawn
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1596844A (en) * | 2004-09-11 | 2005-03-23 | 陈立财 | Artificial nose body for nose raising operation nose artificial body moulding material and moulding knife |
| CN102316826A (en) * | 2007-06-11 | 2012-01-11 | 任基标 | Aiding apparatus for nasal cartilage strut in nasal tip surgery |
| CN101496813A (en) * | 2008-02-03 | 2009-08-05 | 吴昊 | Anti-hyperblastosis (vascular restenosis) composition and application method |
| CN201840502U (en) * | 2010-08-27 | 2011-05-25 | 陈学东 | Device for fixation and compression hemostasis after nasal septum surgery |
| CN103108895A (en) * | 2010-09-17 | 2013-05-15 | 沙伯基础创新塑料知识产权有限公司 | Polycarbonate graft copolymers |
| CN102151339A (en) * | 2011-03-23 | 2011-08-17 | 浙江大学 | Preparation method of silver-carried multilayer film coating biliary tract support frame |
| CN103551055A (en) * | 2013-11-01 | 2014-02-05 | 中国海诚工程科技股份有限公司 | Modifying method of cellulose acetate filtration membrane |
| CN104905893A (en) * | 2015-05-18 | 2015-09-16 | 江苏创发生物科技有限公司 | Anti-infection titanium tantalum bone implantation object and preparing method thereof |
| CN106632864A (en) * | 2016-12-05 | 2017-05-10 | 彭州市运达知识产权服务有限公司 | HDPE multi-monomer graft polymer and preparation method thereof |
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Application publication date: 20180508 |
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