CN107998275A - One kind is used for patients with NIDDM Traditional Chinese medicine for decreasing blood sugar formula - Google Patents
One kind is used for patients with NIDDM Traditional Chinese medicine for decreasing blood sugar formula Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
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Abstract
The invention discloses one kind to be used for patients with NIDDM Traditional Chinese medicine for decreasing blood sugar formula, including following medicinal material species and weight proportion：24 parts of American Ginseng, 15 20 parts of radix scrophulariae, 12 18 parts of the dried rhizome of rehmannia, 10 15 parts of root of Chinese trichosanthes, 12 18 parts of ophiopogon, 9 15 parts of radix astragali, 5 10 parts of rhizoma atractylodis, 10 14 parts of raspberry, 10 15 parts of RHIIZOMA DIOSCOREAE from Henan of China, 10 15 parts of rhizoma anemarrhenae.The present invention needs the positive medicine complementation raspberry of sun according to the rule of traditional Chinese medical science yin yang complementarity using cloudy medicine, and while the deficiency of liver-yin and kidney-yin, diabetic is also contemplated that the deficiency of vital energy, therefore Western life, radix astragali, number medicine and use, is altogether adjutant, and rhizoma atractylodis is make medicine；Consider, the present invention has yin-nourishing to increase heat in liquid system, the diabetes that can be lost with liver-kidney yin deficiency treating diabetes internal injury deficiency of Yin liquid.
Description
Technical field
It is more particularly to a kind of hypoglycemic for patients with NIDDM the present invention relates to traditional Chinese medicine correlative technology field
Chinese medicine preparation.
Background technology
For patients with NIDDM, long term usage Western medicine damage liver, is impairment of the kidney, stimulating intestine and stomach road, the side effect brought, for a long time
Insulin injection simultaneously coordinates blood Sugar Monitoring to be necessary treatment means, however, this can not only bring great pain to patient, also
It may result in the complication such as hypoglycemia.
Diabetes, including type II diabetes, the traditional Chinese medical science thinks to belong to diabete, need to from stasis of blood Coryza Treated by Syndrome Differentiation, the interpretation of the cause, onset and process of an illness loses for kidney yin
Void, production of dryness-heat in the interior, gas consumption hinder Tianjin, with the passing of time venation block, and blood extravasation of blood is excessive to be caused, big by treatment of benefiting qi and nourishing yin invigorating kidney, promoting blood circulation
Method, while integral syndrome differentiation and the local differentiation of disease are combined by the traditional Chinese medical science, form prescription, applying clinical, the traditional Chinese medical science thinks that diabetes are substantially divided
Above to disappear, in disappear and under disappear, above disappear and be divided into lung heat Tianjin wound, in disappear and be divided into that stomach energy is red-hot and deficiency of qi and yin, under disappear and be divided into kidney yin and lose
Empty and yin-yang deficiency, for type II diabetes, deficiency of the liver and kidney accounts for larger proportion, and What is more, and diabetes include II type sugar
Urine disease, complication is very much, there is 23 kinds of complication such as blind, nephrosis, and at present, Western medicine is taken in most for the treatment of to diabetes
Treatment, however, Western medicine can only be palliative, side effect is very big, and liver kidney is further injured.
The content of the invention
The invention belongs to field of traditional Chinese medicine technology, and in particular to it is a kind of be used for patients with NIDDM person it is hypoglycemic in
Medicine composition, it is evident in efficacy, it is without side-effects.The object of the present invention is to provide a kind of tcm product, the product is right to treating diabetes
Hyperglycemic patients, have the significant curative effect of reducing blood glucose, without side-effects, convenient to take, cheap.
To achieve the above object, the present invention provides following technical solution：It is a kind of hypoglycemic for patients with NIDDM
Chinese medicine preparation, including following medicinal material species and weight proportion：2-4 parts of American Ginseng, 15-20 parts of radix scrophulariae, 12-18 parts of the dried rhizome of rehmannia, smallpox
10-15 parts of powder, ophiopogon 12-18 part, 9-15 parts of radix astragali, 5-10 parts of rhizoma atractylodis, 10-14 parts of raspberry, 10-15 parts of RHIIZOMA DIOSCOREAE from Henan of China, rhizoma anemarrhenae
10-15 parts.
Preferably, including following medicinal material species and weight proportion：3 parts of American Ginseng, 15 parts of radix scrophulariae, 15 parts of the dried rhizome of rehmannia, root of Chinese trichosanthes
12 parts, 15 parts of ophiopogon, 10 parts of radix astragali, 5 parts of rhizoma atractylodis, 12 parts of raspberry, 10 parts of RHIIZOMA DIOSCOREAE from Henan of China, 10 parts of rhizoma anemarrhenae.
Further, including following medicinal material species and weight proportion：2 parts of American Ginseng, 15 parts of radix scrophulariae, 12 parts of the dried rhizome of rehmannia, smallpox
10 parts of powder, 12 parts of ophiopogon, 9 parts of radix astragali, 5 parts of rhizoma atractylodis, 10 parts of raspberry, 10 parts of RHIIZOMA DIOSCOREAE from Henan of China, 10 parts of rhizoma anemarrhenae.
Further, including following medicinal material species and weight proportion：4 parts of American Ginseng, 20 parts of radix scrophulariae, 18 parts of the dried rhizome of rehmannia, smallpox
15 parts of powder, 18 parts of ophiopogon, 15 parts of radix astragali, 10 parts of rhizoma atractylodis, 14 parts of raspberry, 15 parts of RHIIZOMA DIOSCOREAE from Henan of China, 15 parts of rhizoma anemarrhenae.
A kind of preparation method for patients with NIDDM Traditional Chinese medicine for decreasing blood sugar formula, comprises the following steps：By raw material
Water body liquid is concentrated to relative density as 1.05, cooling, adds the ethanol of 4 times of amounts, is sufficiently stirred, stand refrigeration 12 it is small when, filter
Cross, after filtrate recycling ethanol, be further continued for being concentrated into silk fabric cream, relative density 1.35, measuring temperature is 55 degree, can take macropore tree
Fat method removes impurity, adds auxiliary material, and auxiliary material is dextrin, and by granulator plasmid, the drying of stream flower beds passes through whole grain, packaging again
Preferably, product testing step is further included：It is qualified come fixed output quota product by detecting the content of Astragaloside IV.
Further, the ethanol for adding 4 times of amounts is more than 95% edible alcohol.
Further, it is 60-80 DEG C to flow flower beds drying temperature.
After table one, zootype are using the present invention, the situation of change (x ± s) of each group blood glucose
Note：A and B is model group, and C groups are control group, and treatment group is the group using Chinese medicine preparation of the present invention, it can be seen that is controlled
Treatment group and two model groups and control group blood sugar level significant difference, significantly reduce (P ﹤ 0.0,5), difference is anticipated with statistics
Justice, shows Chinese medicine preparation treatment type II diabetes significant effect of the present invention.
The change (mmol/L) (x ± s) of preprandial glucose after table two, patients with NIDDM are treated 4 months
Analyzed in patient's type II diabetes therapeutic effect：Treatment group 40, effective 23 (56.0%), effective 16
(40.0%), invalid 1 (0.03%), total effective rate is up to 96.0%；Control group 37, uses Western medicine Metformin hydrochloride, agent
Measure by specification to use, effective 8 (21.6%), effective 26 (70.2%), invalid 3, total effective rate is carried up to 91.2%
Show, the present invention can have a better effect, and significantly reduce (P ﹤ 0.05), and difference has statistical significance, and is free from side effects.
The change of preprandial glucose, serum urea nitrogen (BUN), creatinine (Cr) after table three, patients with NIDDM are treated 4 months
(x±s)
The present invention selection dried rhizome of rehmannia, ophiopogon, root of Chinese trichosanthes, rhizoma atractylodis, RHIIZOMA DIOSCOREAE from Henan of China, raspberry, rhizoma anemarrhenae, American Ginseng, radix astragali are as former
Material, is combined by proportioning, according to certain technique, is processed into granule.
The technique effect and advantage of the present invention：The present invention uses radix scrophulariae, bitter salty and cool, and nourishing Yin and moistening dryness, strong water water, open kidney
Water and to make interior heat be monarch drug in a prescription, dried rhizome of rehmannia sweetness and bitterness and tremble with fear, clearing heat and nourishing yin strengthens aquatic Tianjin to strengthen the power of radix scrophulariae nourishing Yin and moistening dryness, root of Chinese trichosanthes,
Strengthen the power of nourishing Yin and moistening dryness, be altogether ministerial drug, according to the rule of traditional Chinese medical science yin yang complementarity, need the positive medicine complementation of sun to cover basin using cloudy medicine
Son, while the deficiency of liver-yin and kidney-yin, diabetic is also contemplated that the deficiency of vital energy, therefore Western life, radix astragali, number medicines and use, is altogether adjutant, grey
Art is to make medicine；Consider, the present invention has yin-nourishing to increase heat in liquid system, can be lost with liver-kidney yin deficiency treating diabetes internal injury deficiency of Yin liquid
Diabetes.
Embodiment
The technical solution in the embodiment of the present invention will be clearly and completely described below, it is clear that described implementation
Example is only part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, this area is common
Technical staff's all other embodiments obtained without making creative work, belong to the model that the present invention protects
Enclose.
One kind is used for patients with NIDDM Traditional Chinese medicine for decreasing blood sugar formula, including following medicinal material species and weight proportion：West
2-4 parts of American ginseng, 15-20 parts of radix scrophulariae, 12-18 parts of the dried rhizome of rehmannia, 10-15 parts of root of Chinese trichosanthes, ophiopogon 12-18 part, 9-15 parts of radix astragali, rhizoma atractylodis 5-
10 parts, 10-14 parts of raspberry, 10-15 parts of RHIIZOMA DIOSCOREAE from Henan of China, 10-15 parts of rhizoma anemarrhenae.
Embodiment one：
One kind is used for patients with NIDDM Traditional Chinese medicine for decreasing blood sugar formula, including following medicinal material species and weight proportion：West
3 parts of American ginseng, 15 parts of radix scrophulariae, 15 parts of the dried rhizome of rehmannia, 12 parts of root of Chinese trichosanthes, 15 parts of ophiopogon, 10 parts of radix astragali, 5 parts of rhizoma atractylodis, 12 parts of raspberry, bosom
10 parts of Chinese yam, 10 parts of rhizoma anemarrhenae.
Embodiment two：
One kind is used for patients with NIDDM Traditional Chinese medicine for decreasing blood sugar formula, including following medicinal material species and weight proportion：West
2 parts of American ginseng, 15 parts of radix scrophulariae, 12 parts of the dried rhizome of rehmannia, 10 parts of root of Chinese trichosanthes, 12 parts of ophiopogon, 9 parts of radix astragali, 5 parts of rhizoma atractylodis, 10 parts of raspberry, Huai Shan
10 parts of medicine, 10 parts of rhizoma anemarrhenae.
Embodiment three：
One kind is used for patients with NIDDM Traditional Chinese medicine for decreasing blood sugar formula, including following medicinal material species and weight proportion：West
4 parts of American ginseng, 20 parts of radix scrophulariae, 18 parts of the dried rhizome of rehmannia, 15 parts of root of Chinese trichosanthes, 18 parts of ophiopogon, 15 parts of radix astragali, 10 parts of rhizoma atractylodis, 14 parts of raspberry, bosom
15 parts of Chinese yam, 15 parts of rhizoma anemarrhenae.
A kind of preparation method for patients with NIDDM Traditional Chinese medicine for decreasing blood sugar formula, comprises the following steps：By raw material
Water body liquid is concentrated to relative density as 1.05, cooling, adds the ethanol of 4 times of amounts, is sufficiently stirred, stand refrigeration 12 it is small when, filter
Cross, after filtrate recycling ethanol, be further continued for being concentrated into silk fabric cream, relative density 1.35, measuring temperature is 55 degree, can take macropore tree
Fat method removes impurity, adds auxiliary material, and auxiliary material is dextrin, and by granulator plasmid, the drying of stream flower beds passes through whole grain, packaging again.
Preferably, product testing step is further included：It is qualified come fixed output quota product by detecting the content of Astragaloside IV.
Further, the ethanol for adding 4 times of amounts is more than 95% edible alcohol.
Further, it is 60-80 DEG C to flow flower beds drying temperature.
The effect of Chinese medicine and quality standard in the present invention
American Ginseng
【Nature and flavor】It is sweet, slight bitter, cool.
【Channel tropism】Return lung, the heart, kidney, the spleen channel
【Effect】Boosting qi and nourishing yin, clearing heat and promoting fluid., impairment of both QI and YIN, pyreticosis gas impairment of yin is thirsty and quenches one's thirst.
According to《High performance liquid chromatography test stone operation sequence》Measure.Chromatographic condition is with system suitability with 18
Alkyl silane bonded silica gel is filler；Using acetonitrile as mobile phase A, using 0.1% phosphoric acid solution as Mobile phase B, according to the form below
Regulation carries out gradient elution；Detection wavelength is 203nm；40 DEG C of column temperature.Number of theoretical plate is calculated by ginsenoside Rb1 peak to be not less than
5000.Time (minute) mobile phase A (%) Mobile phase B (%) 0~25 19 → 20 81 → 80,25~60 20 → 40 80 →
The preparation of 60,60~90 40 → 55 60 → 45,90~100 55 → 60 45 → 40 reference substance solutions takes ginsenoside Rg1 couple
It is appropriate according to product, ginsenoside Re's reference substance, ginsenoside Rb1's reference substance, it is accurately weighed, add methanol that every 1m1 is made and respectively contain ginseng
Saponin(e.Rg10.1mg, ginsenoside Re 0.4mg, the solution of ginsenoside Rb1 1mg, to obtain the final product.The preparation of test solution takes this
Product powder (crossing No. three sieves) about 1g, it is accurately weighed, put in conical flask with cover, precision adds water saturated n-butanol 50ml, weighed
Weight, when putting that heating and refluxing extraction 1.5 is small in water-bath, lets cool, then weighed weight, and the weight of less loss is supplied with water-saturated n-butanol
Amount, shakes up, and filters.Precision measures subsequent filtrate 25ml, puts in evaporating dish, is evaporated, and residue adds 50% methanol to make dissolving in right amount, transfer
Into 10ml measuring bottles, add 50% methanol to shake up to scale, filter, take subsequent filtrate, to obtain the final product.
Determination method difference is accurate to draw reference substance solution and each 10 μ l of test solution, injects liquid chromatograph, measures, i.e.,
.This product contains ginsenoside Rg1 (C42H72O14), ginsenoside Re (C48H82O18) and ginsenoside Rb1 (C54H92O23)
Total amount must not be less than 2.0%, be judged to qualification.
Radix scrophulariae
【Nature and flavor】It is sweet, bitter, salty.
【Channel tropism】Return lung, stomach, kidney channel
【Effect】Purging intense heat and detonicating, clearing heat and cooling blood, Yin-nourishing and body fluid promoting.Consumption of body fluid caused by febrile disease, Heat Diabetes, yin asthenia generating intrinsic heat, hectic fever due to yin labor is thirsty,
Tianjin hinder constipation.
According to《High performance liquid chromatography test stone operation sequence》Measure.
Chromatographic condition is with system suitability using octadecylsilane chemically bonded silica as filler；Using acetonitrile as mobile phase
A, using 0.03% phosphoric acid solution as Mobile phase B, the regulation according to the form below carries out gradient elution；Detection wavelength is 210nm.Theoretical plate
Number is calculated by harpagoside with harpagide peak should all be not less than 5000.The preparation of reference substance solution takes harpagide reference substance, Ha Ba
Russia's glycosides reference substance is appropriate, accurately weighed, adds 30% methanol that mixing of every 1ml containing 60 μ g of harpagide, 20 μ g of harpagoside is made molten
Liquid, to obtain the final product.The preparation of test solution takes this product powder (crossing No. three sieves) about 0.5g, accurately weighed, puts in conical flask with cover, essence
50% methanol 50ml of close addition, close plug, weighed weight, when immersion 1 is small, 45 points of supersound process (power 500W, frequency 40kHz)
Clock, lets cool, then weighed weight, and the weight of less loss is supplied with 50% methanol, is shaken up, and filtration, takes subsequent filtrate, to obtain the final product.Determination method point
It is accurate to draw reference substance solution and each 10 μ l of test solution, inject liquid chromatograph, measure, to obtain the final product.This product presses dry product
Calculate, the total amount containing harpagide (C15H24O10) and harpagoside (C24H30O11) must not be less than 0.45%, be judged to qualification.
The dried rhizome of rehmannia
【Nature and flavor】It is sweet, bitter, cold.
【Channel tropism】The thoughts of returning home, liver and kidney channel
【Effect】Nourishing Yin and promoting production of body fluid, clearing heat and cooling blood, injury thirst, Heat Diabetes, yin asthenia generating intrinsic heat, hectic fever due to yin labor are hot, heat enters ying blood,
The deep red polydipsia of tongue, dry constipation of intestines.
Catalpol shines《High performance liquid chromatography test stone operation sequence》Measure.Chromatographic condition and system suitability with
Octadecylsilane chemically bonded silica is filler；With 0.1% phosphoric acid solution (1 of acetonitrile：99) it is mobile phase；Detection wavelength is
210nm.Number of theoretical plate is calculated by Catalpol peak should be not less than 5000.The preparation of reference substance solution takes Catalpol reference substance appropriate, accurate
It is weighed, add mobile phase that the solution of every 1ml μ containing l0 g is made, to obtain the final product.The preparation of test solution takes this product (radix rehmanniae recen) to be cut into about
The fritter of 5mm, through 80 DEG C be dried under reduced pressure 24 it is small when after, wear into coarse powder, take about 0.8g, it is accurately weighed, put in conical flask with cover, essence
Close addition methanol 50m1, weighed weight, when heating and refluxing extraction 1.5 is small, lets cool, then weighed weight, and less loss is supplied with methanol
Weight, shakes up, and filtration, precision measures filtered fluid 10ml, is concentrated into and closely does, and residue flowing phased soln, is transferred to 10ml measuring bottles
In, and scale is diluted to mobile phase, shake up, filter, take subsequent filtrate, to obtain the final product.Determination method is accurate respectively to draw reference substance solution
With each 10 μ l of test solution, inject liquid chromatograph, measure, to obtain the final product.Radix rehmanniae recen is calculated by dry product, containing Catalpol
(C15H22O10) 0.20% must not be less than.Acteoside shines《High performance liquid chromatography test stone operation sequence》Measure.Color
Spectral condition is with system suitability using octadecylsilane chemically bonded silica as filler；With one 0.1% acetum of acetonitrile
(16：84) it is mobile phase；Detection wavelength is 334nm.Number of theoretical plate is calculated by acteoside peak should be not less than 5000.Reference substance
Prepared by solution takes acteoside reference substance appropriate, accurately weighed, adds mobile phase that solution of every 1ml containing 10ttg is made, to obtain the final product.
Test solution prepare it is accurate measure subsequent filtrate 20ml under [assay] item Catalpol item, be recovered under reduced pressure that solvent is closely dry, and residue is used
Flow phased soln, be transferred in 5ml measuring bottles, add mobile phase to shake up to scale, filter, take filtered fluid, to obtain the final product.Determination method is distinguished
Precision draws reference substance solution and each 20 μ l of test solution, notes people's liquid chromatograph, measures, to obtain the final product.Radix rehmanniae recen presses dry product
Calculate, 0.020% must not be less than containing acteoside (C29H36O15), be judged to qualification.
Ophiopogon
【Nature and flavor】Sweet, slight bitter, be slightly cold.
【Channel tropism】Return stomach, lung, the heart channel of Hang-Shaoyin
【Effect】Moistening lung clears away heart-fire, nourishing Yin and promoting production of body fluid, the stomach-Yin chronic diseases marked by deficiency of vital energy, the lung yin chronic diseases marked by deficiency of vital energy, the heart-yin chronic diseases marked by deficiency of vital energy.
The preparation of reference substance solution takes ruscogenin reference substance appropriate, accurately weighed, adds methanol that every 1ml is made containing 50
The solution of μ g, to obtain the final product.The preparation of standard curve is accurate to measure reference substance solution 0.5ml, 1ml, 2ml, 3ml, 4ml, 5ml, 6ml,
Put respectively in tool plug test tube, the solvent flashing in water-bath, precision adds perchloric acid 10ml, shakes up, puts and 15 minutes are kept the temperature in hot water
Take out, frozen water cooling, using corresponding reagent as blank, according to ultraviolet-visible spectrophotometry (annex VA), surveyed at 397nm wavelength
Determine absorbance, using absorbance as ordinate, concentration is abscissa, draws standard curve.Determination method takes this product fine powder about 3g, accurate
It is weighed, put in conical flask with cover, precision adds methanol 50ml, weighed weight, be heated to reflux 2 it is small when, let cool, then weighed weight,
The weight of less loss is supplied with methanol, is shaken up, is filtered, precision measures filtered fluid 25ml, and for recycling design to doing, residue adds water 10ml to make
Dissolving, with water-saturated n-butanol shaking extraction 5 times, each 10ml, merges n-butanol liquid, is washed 2 times, each 5ml with ammonia solution,
Ammoniacal liquor is discarded, n-butanol liquid is evaporated.Residue is dissolved with 80% methanol, is transferred in 50m1 measuring bottles, adds 80% methanol to be shaken to scale
It is even.Precision measures 2~5ml of test solution, puts in 10ml tool plug test tubes, the method under the preparation of sighting target directrix curve, from " in
Solvent is volatilized in water-bath " rise, absorbance is measured in accordance with the law, and the weight of ruscogenin in test solution is read from standard curve
Amount, calculates, to obtain the final product.This product is calculated by dry product, containing dwarf lilyturf tuber total saponins in terms of ruscogenin (C27H42O4), must not be less than
0.12%, it is judged to qualification.
Root of Chinese trichosanthes
【Nature and flavor】Sweet, slight bitter, be slightly cold.
【Channel tropism】Return stomach, lung channel
【Effect】Clearing heat-fire, promote the production of body fluid to quench thirst, detumescence and apocenosis, pyreticosis polydipsia, lung heat dry thirsty, Heat Diabetes, pyogenic infections.
【Differentiate】(1) this product powder off-white color.Amylum body is a lot of, and simple grain is spherical, semicircle or helmet hat shape, and diameter 6~
48 μm, omphalion point-like, short gap-like or people's shape, laminated striation may be seen indistinctly；Composite grain is made of 2~14 gradation, often by a big point
Grain is compound with several small gradation.Bordered pit vessel is big, and more broken, some bordered pits are in hexagon or square, and arrangement is close.
Lithocyte yellow green, rectangle, ellipse, class are square, polygonal or spindle, and 27~72 μm of diameter, wall is thicker, and pit is thin
It is close.(2) this product powder 2g is taken, adds Diluted Alcohol 20ml, is ultrasonically treated 30 minutes, filtration, takes filtrate as test solution.Separately take
Root of Chinese trichosanthes control medicinal material 2g, is made in the same way of control medicinal material solution.Citrulling reference substance is taken again, is added Diluted Alcohol that every 1ml is made and is contained 1mg
Solution, as reference substance solution.According to《Thin-layered chromatography test stone operation sequence》(VI B of annex) is tested, and draws test sample
Solution and each 2 μ 1 of control medicinal material solution, 1 μ l of reference substance solution, put on same silica gel g thin-layer plate, with one nothing of n-butanol respectively
One glacial acetic acid of water-ethanol, one water (8：2：2：3) it is solvent, is unfolded, take out, dry, spray with ninhydrin solution, in 105 DEG C of heating
It is clear to spot development.In test sample chromatography, on position corresponding with control medicinal material chromatography and reference substance chromatography, identical face is shown
The spot of color.
Rhizoma atractylodis
【Nature and flavor】Pungent, slight bitter, temperature.
【Channel tropism】Return stomach, liver, the spleen channel
【Effect】Drying damp and strengthening spleen, expelling wind and clearing away cold, damp retention in middle-jiao, rheumatic Bi syndrome, chill press from both sides wet table disease.
Lucifuge operates.According to《High performance liquid chromatography test stone operation sequence》Measure.Chromatographic condition and system suitability
Experiment is using octadecylsilane chemically bonded silica as filler；With one water (79 of methanol：21) it is stream phase；Detection wavelength is 340nm.Reason
5000 should be not less than by being calculated by plate number by Atisine chloride Atractydin peak.The preparation of reference substance solution takes Atisine chloride Atractydin reference substance appropriate, accurately weighed,
Add methanol that the solution that every 1ml contains 20 μ l is made, to obtain the final product.Prepared by test solution takes this product powder (crossing No. three sieves) about 0.2g, essence
It is close weighed, put in conical flask with cover, precision adds methanol 50ml, and close plug, weighed weight, is ultrasonically treated (power 250W, frequency
40kHz) 1 it is small when, let cool, then weighed weight, the weight of less loss supplied with methanol, is shaken up, filter, take subsequent filtrate, to obtain the final product.Measure
Method difference is accurate to draw reference substance solution and each 10 μ l of test solution, injects liquid chromatograph, measures, to obtain the final product.This product is by dry
Dry product calculate, and must not be less than 0.30% containing Atisine chloride Atractydin (C13H10O), be judged to qualification.
RHIIZOMA DIOSCOREAE from Henan of China
【Nature and flavor】It is sweet, flat.
【Channel tropism】Return lung, kidney, the spleen channel
【Effect】Tonifying spleen nourishing the stomach, engender liquid and benefic lung, the puckery essence of kidney tonifying, spleen deficiency, deficiency syndrome of the lung disease, kidney deficiency, deficiency of both qi and yin of quenching one's thirst.
【Differentiate】(1) this product powder off-white color.Amylum body simple grain it is flat it is avette, triangular shape is avette, similar round or square are circular, directly
8~35 μm of footpath, omphalion point-like, people's shape, crosswise or short gap-like, it is seen that laminated striation；Composite grain is rare, is made of 2~3 gradation.Grass
Sour calcium raphides is present in mucilage cell, is about to 240 μm, thick 2~5 μm of needle.Bordered pit vessel, reticulate vessel, spiral shell
12~48 μm of line conduit and annular duct diameter.(2) take this product powder 5g, add methylene chloride 30ml, be heated to reflux 2 it is small when, filter
Cross, filtrate is evaporated, and the residue 1ml that adds methylene chloride makes dissolving, as test solution.Separately take Chinese yam control medicinal material 5g, same to legal system
Into control medicinal material solution.Tested according to thin-layered chromatography (VI B of annex), draw each 4 μ l of above two solution, put respectively in same silicon
On glue G lamellaes, with acetate-methanol-strong ammonia solution (9：1：O.5 it is) solvent, is unfolded, takes out, dry, spray with 10%
Phosphomolybdic acid ethanol solution, it is clear to be heated to spot development at 105 DEG C.In test sample chromatography, corresponding with control medicinal material chromatography
On position, the spot of same color is shown.
Raspberry
【Nature and flavor】Sweet, sour, tepor.
【Channel tropism】Return, liver and kidney channel
【Effect】The puckery urine of controlling nocturnal emission with astringent drugs, liver and kidney benefiting improving eyesight, emission and spermatorrhea, enuresis frequent micturition, kidney deficiency and liver, mesh are secretly unknown.
【Differentiate】This product powder brown color.Nonglandular hair is unicellular, and 60~450 μm long, 12~20 μm of diameter, wall is very thick, wood
To change, most of tool double threads, some body portions are easy to fall off, and foot remains and is embedded in epidermis, and circle polygonal or oval are seen in surface,
Diameter is about to 23 μm, cell branch, like lithocyte shape.Calcium oxalate cluster crystal is more common, 18~50 μm of diameter.Pericarp fiber yellow,
Levels in length and breadth or oblique are staggered.
Rhizoma anemarrhenae
【Nature and flavor】It is bitter, sweet, cold.
【Channel tropism】Return stomach, lung, kidney channel
【Effect】Fluid dryness, clearing heat-fire, pyreticosis polydipsia, lung-heat type cough, osteopyrexia and fever, Heat Diabetes, dry constipation of intestines.
Take this product powder (crossing No. three sieves) about 1g [while separately taking this product powder to measure moisture (Ⅸ the first methods of H of annex)], essence
It is close weighed, put in conical flask, precision plus ethanol 25ml, weighed weight, soaked overnight, is ultrasonically treated 40 minutes, lets cool, then weighed
Weight, the weight of less loss is supplied with ethanol, is shaken up, and filtration, precision measures subsequent filtrate 10ml, adds hydrochloric acid 1ml, is put in water-bath with steaming
When the slow reflux 1 of gas is small, lets cool, be poured into small beaker, 40% sodium hydroxide solution is added dropwise in shaking to neutral (solution colour
By it is orange sport it is orange red), with ethanol washing container, washing lotion is incorporated in beaker.Moved in 50ml measuring bottles, and be diluted to ethanol
Scale, shakes up, and filtration, precision measures subsequent filtrate 10ml and puts in evaporating dish, is evaporated, residue is dissolved with benzene, is transferred to 2ml measuring bottles
In, and scale is diluted to, shake up, as test solution.Separately take sarsasapogenin reference substance appropriate, it is accurately weighed, add benzene system
Into solution of every 1ml containing 0.5mg, as reference substance solution.Tested according to thin-layered chromatography (VI B of annex), precision draws test sample
4 μ l of solution, reference substance solution 2 μ l and 6 μ l, crosspoint is in same thin using sodium carboxymethylcellulose as the silica G of binder respectively
On laminate, with benzene-acetone (9:1) it is solvent, opens up to 7cm, take out, dry, then second outspread is carried out with same solvent,
Take out, dry, spray with color developing agent [solution A：Fetch water 25ml, slowly adds sulfuric acid 50ml, after letting cool, then adds ethanol 25ml, shakes up；Second
Liquid：8% vanillic aldehyde ethanol solution.Used time mixes 5 parts of solution A for 1 part with second liquid] after, heat 7~10 minutes at 70 DEG C, extremely
Spot development is clear, takes out, an equal amount of glass plate is covered on lamellae, around with immobilization with adhesive tape, according to thin-layered chromatography
(VI B thin layer chromatography scannings of annex) is scanned, wavelength X S=443nm, and measurement test sample trap integrated value is absorbed with reference substance
Spend integrated value, calculate, to obtain the final product.This product is calculated by dry product, must not be less than 1.0% containing sarsasapogenin (C27H44O3), is judged to
It is qualified.
Radix astragali
【Nature and flavor】Sweet, tepor.
【Channel tropism】Return lung, the spleen channel
【Effect】Tonifying spleen bowl spares, rising Yang act, invigorating qi for consolidating superficies, diuresis, promoting pus discharge and tissue regeneration, Spleen-Qi Deficiency, Lung Qi deficiency, spontaneous perspiration due to deficiency of vital energy,
Deficiency of qi and blood, drying damp and strengthening spleen, expelling wind and clearing away cold, damp retention in middle-jiao, rheumatic Bi syndrome, chill press from both sides wet table disease.
Astragaloside IV is measured according to high performance liquid chromatography (VI D of annex).
Chromatographic condition is with system suitability using octadecylsilane chemically bonded silica as filler；With acetonitrile water (32：
68) it is mobile phase；Evaporative light scattering detector detects.Number of theoretical plate is calculated by Astragaloside IV peak should be not less than 4000.Reference substance
The preparation of solution takes Astragaloside IV reference substance appropriate, accurately weighed, adds methanol that solution of every 1m1 containing 0.5mg is made, to obtain the final product.For
The preparation of test sample solution takes powder about 4g in this product, accurately weighed, puts in apparatus,Soxhlet's, adds methanol 40m1, and cold soaking is overnight, then adds
Appropriate methanol, be heated to reflux 4 it is small when, extracting solution recycling design is simultaneously concentrated to dryness, and residue adds water 10ml, and low-grade fever makes dissolving, uses water
The n-butanol shaking extraction 4 times, each 40ml of saturation, merges n-butanol liquid, is fully washed with ammonia solution 2 times, each 40ml, is abandoned
Ammoniacal liquor is removed, n-butanol liquid is evaporated, and residue adds water 5m1 to make dissolving, lets cool, and (internal diameter is by D101 types large pore resin absorption column
1.5cm, pillar height 12cm), eluted with water 50m1, discard aqueous, then eluted with 40% ethanol 30rnl, discard eluent, after with
70% ethanol 80ml is eluted, and is collected eluent, is evaporated, and residue adds methanol to dissolve, and is transferred in 5ml measuring bottles, adds methanol to scale,
Shake up, to obtain the final product.Determination method is accurate respectively to draw 10 μ l of reference substance solution, 20 μ l, 20 μ l of test solution injection liquid chromatograph,
Measure, is calculated, with external standard two-point method logarithmic equation to obtain the final product.This product is calculated by dry product, must not containing Astragaloside IV (C41H68O14)
Less than 0.040%.Calycosin glucoside is measured according to high performance liquid chromatography (VI D of annex).Chromatographic condition is fitted with system
Tested with property using octadecylsilane chemically bonded silica as filler；Using acetonitrile as mobility A, using 0.2% formic acid solution as flowing
Phase B, the regulation according to the form below carry out gradient elution；Detection wavelength is 260nm.Number of theoretical plate presses calycosin glucoside peak
3000 should be not less than by calculating.Time (minute) mobile phase A % Mobile phase Bs %0~2020 → 4080 → 6020~304060, control
The preparation of product solution takes calycosin glucoside reference substance appropriate, accurately weighed, adds methanol that every 1ml is made molten containing 50 μ g
Liquid, to obtain the final product.The preparation of test solution takes this product powder (crossing No. four sieves) about 1g, accurately weighed to put in round-bottomed flask, and precision adds
Enter methanol 50ml, weighed weight, be heated to reflux 4 it is small when, let cool, then weighed weight, the weight of less loss supplied with methanol, is shaken up,
Filtration, precision measure subsequent filtrate 25ml, and for recycling design to doing, residue adds methanol to dissolve, and is transferred in jml measuring bottles, adds methanol extremely
Scale, shakes up, to obtain the final product.Determination method is accurate respectively to draw reference substance solution and each 10 μ l of test solution, notes people's liquid chromatograph,
Measure, to obtain the final product.This product is calculated by dry product, and glucoside containing calycosin (C22H22O10) must not be less than 0.020%, sentence
For qualification.
The content of saponins, flavonoids and polysaccharose substance, determines Huang in the Milkvetch Root according to as defined in Chinese Pharmacopoeia
The evaluation index of stilbene chemical quality standard.HPLC-ELS methods measure the content of Astragaloside IV, and Phenol-sulphate acid method measure radix astragali is always more
The content of sugar.Astragaloside IV, the content of total starches are respectively that 1.186 ± 0.024mg/g, 48.800 ± 1.245mg/g are qualification.
The present invention can take the customary preparation methods of Chinese medicine preparation, can be made into the granule said in conventional dose.
Radix scrophulariae is used in invention, bitter salty and cool, nourishing Yin and moistening dryness, strong water water, it is monarch drug in a prescription to open kidney water and make interior heat, and the dried rhizome of rehmannia is sweet
Bitter and tremble with fear, clearing heat and nourishing yin strengthens aquatic Tianjin to strengthen the power of radix scrophulariae nourishing Yin and moistening dryness, root of Chinese trichosanthes, the power of reinforcement nourishing Yin and moistening dryness, is altogether minister
Medicine, according to the rule of traditional Chinese medical science yin yang complementarity, needs the positive medicine complementation raspberry of sun, while the deficiency of liver-yin and kidney-yin, glycosuria using cloudy medicine
Patient is also contemplated that the deficiency of vital energy, therefore Western life, radix astragali, number medicines and use, is altogether adjutant, and rhizoma atractylodis is make medicine.Consider, the present invention
There is yin-nourishing to increase heat in liquid system, the II type glycosuria that can be lost with liver-kidney yin deficiency treating diabetes internal injury deficiency of Yin liquid.
Chinese medicine preparation of the present invention is without side-effects, easy to use, cheap to be counted according to the clinical observation of case more than 1000, this
Invention Chinese medicine preparation total effective rate 95.13%.
Here is clinical statistics data of the diabetic using Chinese medicine preparation of the present invention：
First, general information：
Statistics treatment patient 279 altogether, man 138, female 141, average age 51.56 years old, male to female ratio 0.98:1
2nd, diagnostic criteria：
The frequency of patients with NIDDM self-monitoring of blood glucose, i.e., at least monitor 4 blood glucose (before the meal) daily, and blood glucose is unstable
Timing to monitor 8 times (breakfast, lunch and dinner are forward and backward, it is late sleep before and morning 3：00) condition, treated to patients with NIDDM is：It is empty
Abdomen blood glucose is not controlled less than 7.2 mM/ls, and postprandial two hours blood glucose is more than 10mmol/L, HbA1c more than 7%, or
Preprandial glucose 8.1, glucose in urine is positive, specific gravity of urine is more than 1.023, and urine ketone bodies are positive.Type II diabetes has more disease types, wherein liver kidney yin
Deficiency is in the great majority, and clinical symptoms show as dry more and drink more, soreness and weakness of waist and knees, vexed insomnia etc., the traditional Chinese medical science think it is deficient not on hold,
Then thirsty, most of soreness and weakness of waist and knees, vexed insomnia patient this symptom should be the performances of the deficiency of liver-yin and kidney-yin.
3rd, treatment method
The method according to the invention, each patient takes 10 grams of granules daily, one bag, is taken with warm water, and 4 months are one
A course for the treatment of.
4th, type II diabetes curative effect judging standard：
1. complete incidence graph：Preprandial glucose is below 6.1, glucose in urine+or following, specific gravity of urine 1.023 or less, and urine ketone bodies are cloudy
Property.
2. basic alleviate：Preprandial glucose below 6.1, glucose in urine+or more, specific gravity of urine 1.023, urine ketone bodies are negative.
3. improve：Preprandial glucose is below 6.1, and glucose in urine is positive, specific gravity of urine 1.023, and urine ketone bodies are positive.
It is 4. invalid：Preprandial glucose is below 6.1, glucose in urine +++, specific gravity of urine 1.023, urine ketone bodies are positive.
5th, type II diabetes treatment results
Statistics statistical analysis uses SPSS16.0 software analysis, takes t to examine between group, has system with P ﹤ 0.05 and P ﹤ 0.01
Meter learns meaning.
The animal model experiment effect that the present invention of 5.1 II diabetes treats：It is injected intraperitoneally and is injected using Streptozotocin
Can induced Diabetic, the present invention is SD rats using animal, and for weight at 210-230 grams, the age is 0.7 years old.Streptozotocin
The dosage of (streptozotocin STZ) is 40mg/kg；STZ be it is a kind of contain nitroso compound, into vivo may be used
Beta Cell of islet is specifically destroyed by following mechanism, while gives rat dieting high fat high sugar feed, continuous 4 weeks, green peel 18
Gram, 18 grams of Fructus Aurantii, 13 grams of monkshood, 13 grams of per kilogram, feeds 4 weeks, and obvious deficiency of liver-yin and kidney-yin tcm symptom occurs in rat.STZ exists
It is act as in manufacture diabetes rat model：(1) STZ directly destroys beta Cell of islet：After being mainly seen in injection heavy dose STZ.
After STZ injections the concentration of β internal cell coenzymes I (NAD) can be caused to decline, NAD dependences energy and protein metabolism stop, and cause
β cell deaths；(2) by the synthesis of induced nitrous oxide (NO), beta Cell of islet is destroyed；(3) STZ activates self-immunprocess,
Further result in the infringement of β cells：Dose injection STZ can destroy a small amount of beta Cell of islet, and dead beta Cell of islet can conduct
Antigen is swallowed by macrophage, produces TH1 stimulating factors, is made TH1 cell lines dominant and is produced IL-2 and IFN-γ, in pancreas islet
Part promotes inflammatory cell infiltration, and activates the material killing cell such as release IL-1, TNF-α, IFN-γ, NO and H2O2.It is dead
Cell is handled but also as autoantigen, again submission to antigen presenting cell, discharges cell factor, magnocell damage
Effect, it is final to induce II diabetes.
The modeling of each group SD rats is front and rear and different time blood sugar level (mmol/L) A and B is modeling group, and C is control group, the
Four groups are to Chinese medicine preparation of the invention (dosage is 0.17 gram of per kilogram of body weight).
After table one, zootype are using the present invention, the situation of change (x ± s) of each group blood glucose.
5.2 type II diabetes clinical therapeutic efficacies：
5.2.1, type II diabetes clinical effectiveness 1
The change (mmol/L) (x ± s) of preprandial glucose after table two, patients with NIDDM are treated 4 months.
5.2.2 type II diabetes clinical effectiveness 2
Chinese medicine preparation of the present invention have studied the therapeutic effect on Old Patients With Diabetic Nephropathy.Control group 36, Primary Care are
Control blood glucose, control blood pressure symptomatic treatment；The Primary Care that treatment group is 42 is same as control group, depressor first choice nifedipine 1
Piece, one time a day, adds two groups of Chinese medicine preparation of the present invention with 3 months as 1 course for the treatment of, and statistical observation result is such as after the course for the treatment of
Under, in treatment group 42, effective 16, effective 22, invalid 4 effect, effective percentage 90%；In control group 36, effective 5, have
Effect 20, invalid 11 effect, effective percentage 69%, significantly reduces (P ﹤ 0.01), difference has statistical significance.Experiment proves the present invention
Drug matching is reasonable, evident in efficacy, significantly reduces (P ﹤ 0.01), and difference has statistical significance, can significantly reduce old glycosuria
Disease, improve diabetic's renal function, for Enema compress treat diabetes provide one well by way of, according to clinical verification,
Chinese medicine preparation curative effect of the present invention is fast, and good effect is without side-effects few.
5.2.3, type II diabetes clinical effectiveness 3
We observe patients with NIDDM, while have the patient of nephrosis, after Chinese medicine of the present invention is taken one month, blood
Urea nitrogen (BUN), creatinine (Cr) changes of contents in liquid, discovery play the role of reduction urea nitrogen (BUN), creatinine (Cr) content.
Statistical analysis uses SPSS16.0 software analysis, takes t to examine between group, has statistical significance with P ﹤ 0.05 and P ﹤ 0.01.
In general, all diabetics, the patient that nephrosis is especially suffered from because of diabetes, blood urea nitrogen (BUN)
Normal healthy people is all remarkably higher than with creatinine (Cr) equivalence, after Chinese medicine preparation of the present invention one month, in diabetic's blood
Cr, BUN content significantly reduce (P ﹤ 0.01), and difference has statistical significance, the results show that Chinese medicine of the present invention not only can be effective
Ground reduces blood-sugar content in type II diabetes people's blood, can also reduce Cr, BUN content in blood, such as uses Chinese medicine preparation of the present invention
Medication two months or so, and may be such that the continual and steady decline of their blood plasma level, thus the kidney under morbid state can be mitigated
Bead progressive damages, and for protecting renal function, with reasoning Chinese medicine preparation of the present invention the development of diabetes can be delayed to have positive work
With.
The change of preprandial glucose, serum urea nitrogen (BUN), creatinine (Cr) after table three, patients with NIDDM are treated 4 months
(x±s)。
The typical case of 5.3 type II diabetes
1. Lee, man, 47 years old, the teacher of mono- school of Anhui Tian Changxian, over nearly three months, diuresis, more foods, more drinks, disappeared
Thin, daily to have urine more than 20 times, drink does not quench the thirst, and comes Anhui institute of traditional Chinese medicine to go to a doctor, preprandial glucose 8.1. blood gps 7.4, have height concurrently
Blood pressure, hyperlipidemia, are diagnosed as type II diabetes, take after originally matching somebody with somebody 4 months, preprandial glucose 5.4, blood gp 5.9, the results showed that
Curative effect is very notable.
2. Hu, female, 50 years old, has no property, Hefei City people, from last year, thirst with desire to drink water, urine is more, likes cold water, is hard and dry, the heart
Throb with fear.Sleep hyperhidrosis, come Anhui institute of traditional Chinese medicine to go to a doctor, preprandial glucose 7.6, blood gp 8.9. is fat, has hyperlipidemia concurrently, is diagnosed as
Type II diabetes, after taking this formula 4 months, preprandial glucose 6.1, blood gp 7.1, the results showed that curative effect is very notable.
3. Chen is male, 55 years old, cadre, Hefei people, closely over the past half year, drink more, diuresis, lassitude, body is become thin, appetite
Greatly, urine is pleasantly sweet, comes Anhui institute of traditional Chinese medicine to go to a doctor, preprandial glucose 11.3. blood gps 9.3, have hypertension concurrently, be diagnosed as II type
Diabetes, after taking this formula 4 months, 6.4 blood gp 7.4 of preprandial glucose, the results showed that curative effect is very notable.
3 groups of embodiments can be made for patients with NIDDM Traditional Chinese medicine for decreasing blood sugar formula, wherein the 1st more than
The obtained patients with NIDDM Traditional Chinese medicine for decreasing blood sugar formulation efficacy that is used for of group embodiment is best, and the present invention uses radix scrophulariae, bitter salty
And cool, nourishing Yin and moistening dryness, strong water water, it is monarch drug in a prescription to open kidney water and make interior heat, dried rhizome of rehmannia sweetness and bitterness and tremble with fear, clearing heat and nourishing yin, strong aquatic Tianjin with
Strengthening the power of radix scrophulariae nourishing Yin and moistening dryness, root of Chinese trichosanthes, strengthens the power of nourishing Yin and moistening dryness, is altogether ministerial drug, according to the rule of traditional Chinese medical science yin yang complementarity,
The positive medicine complementation raspberry of sun is needed using cloudy medicine, while the deficiency of liver-yin and kidney-yin, diabetic is also contemplated that the deficiency of vital energy, therefore Western
Raw, radix astragali, number medicine and use, are altogether adjutant, and rhizoma atractylodis are to make medicine；Consider, the present invention has yin-nourishing to increase heat in liquid system, can be with liver kidney
The diabetes that YIN-deficiency type treating diabetes internal injury deficiency of Yin liquid loses.
Finally it should be noted that：The foregoing is only a preferred embodiment of the present invention, is not intended to limit the invention,
Although the present invention is described in detail with reference to the foregoing embodiments, for those skilled in the art, it still may be used
To modify to the technical solution described in foregoing embodiments, or equivalent substitution is carried out to which part technical characteristic,
Within the spirit and principles of the invention, any modification, equivalent replacement, improvement and so on, should be included in the present invention's
Within protection domain.
Claims (8)
1. one kind is used for patients with NIDDM Traditional Chinese medicine for decreasing blood sugar formula, it is characterised in that including following medicinal material species and again
Amount proportioning：2-4 parts of American Ginseng, 15-20 parts of radix scrophulariae, 12-18 parts of the dried rhizome of rehmannia, 10-15 parts of root of Chinese trichosanthes, ophiopogon 12-18 part, radix astragali 9-15
Part, 5-10 parts of rhizoma atractylodis, 10-14 parts of raspberry, 10-15 parts of RHIIZOMA DIOSCOREAE from Henan of China, 10-15 parts of rhizoma anemarrhenae.
2. one kind according to claim 1 is used for patients with NIDDM Traditional Chinese medicine for decreasing blood sugar formula, it is characterised in that bag
Include following medicinal material species and weight proportion：3 parts of American Ginseng, 15 parts of radix scrophulariae, 15 parts of the dried rhizome of rehmannia, 12 parts of root of Chinese trichosanthes, 15 parts of ophiopogon, radix astragali
10 parts, 5 parts of rhizoma atractylodis, 12 parts of raspberry, 10 parts of RHIIZOMA DIOSCOREAE from Henan of China, 10 parts of rhizoma anemarrhenae.
3. one kind according to claim 1 is used for patients with NIDDM Traditional Chinese medicine for decreasing blood sugar formula, it is characterised in that bag
Include following medicinal material species and weight proportion：2 parts of American Ginseng, 15 parts of radix scrophulariae, 12 parts of the dried rhizome of rehmannia, 10 parts of root of Chinese trichosanthes, 12 parts of ophiopogon, radix astragali
9 parts, 5 parts of rhizoma atractylodis, 10 parts of raspberry, 10 parts of RHIIZOMA DIOSCOREAE from Henan of China, 10 parts of rhizoma anemarrhenae.
4. one kind according to claim 1 is used for patients with NIDDM Traditional Chinese medicine for decreasing blood sugar formula, it is characterised in that bag
Include following medicinal material species and weight proportion：4 parts of American Ginseng, 20 parts of radix scrophulariae, 18 parts of the dried rhizome of rehmannia, 15 parts of root of Chinese trichosanthes, 18 parts of ophiopogon, radix astragali
15 parts, 10 parts of rhizoma atractylodis, 14 parts of raspberry, 15 parts of RHIIZOMA DIOSCOREAE from Henan of China, 15 parts of rhizoma anemarrhenae.
A kind of 5. preparation for patients with NIDDM Traditional Chinese medicine for decreasing blood sugar formula as described in claim 1-4 any one
Method, it is characterised in that comprise the following steps：It is 1.05 that raw material is concentrated to relative density by water body liquid, and cooling, adds 4 times
The ethanol of amount, is sufficiently stirred, and when standing refrigeration 12 is small, filters, after filtrate recycling ethanol, is further continued for being concentrated into silk fabric cream, relatively close
Spend for 1.35, measuring temperature is 55 degree, Amberlyst process can be taken to remove impurity, addition auxiliary material, auxiliary material is dextrin, passes through granulation
Machine plasmid, the drying of stream flower beds pass through whole grain, packaging again.
6. one kind according to claim 5 is used for patients with NIDDM Traditional Chinese medicine for decreasing blood sugar formula, it is characterised in that also
Including product testing step：It is qualified come fixed output quota product by detecting the content of Astragaloside IV.
7. one kind according to claim 5 is used for patients with NIDDM Traditional Chinese medicine for decreasing blood sugar formula, it is characterised in that adds
The ethanol for entering 4 times of amounts is more than 95% edible alcohol.
8. one kind according to claim 5 is used for patients with NIDDM Traditional Chinese medicine for decreasing blood sugar formula, it is characterised in that stream
Flower beds drying temperature is 60-80 DEG C.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110946930A (en) * | 2019-10-31 | 2020-04-03 | 贵州省兴仁市中医院 | Formula for treating qi deficiency type diabetes and preparation method thereof |
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| CN101530565A (en) * | 2009-04-17 | 2009-09-16 | 河北金大地房地产开发有限公司 | Chinese traditional medicine preparation used for curing diabetes and preparation method thereof |
| CN106266543A (en) * | 2016-09-10 | 2017-01-04 | 四川金堂海纳生物医药技术研究所 | A kind of Chinese medicine composition treating type Ⅱdiabetes mellitus and preparation method thereof |
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| CN101530565A (en) * | 2009-04-17 | 2009-09-16 | 河北金大地房地产开发有限公司 | Chinese traditional medicine preparation used for curing diabetes and preparation method thereof |
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| CN110946930A (en) * | 2019-10-31 | 2020-04-03 | 贵州省兴仁市中医院 | Formula for treating qi deficiency type diabetes and preparation method thereof |
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