CN107998203A - A kind of external medicine composition for treating dyskinesia and preparation method thereof - Google Patents
A kind of external medicine composition for treating dyskinesia and preparation method thereof Download PDFInfo
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- CN107998203A CN107998203A CN201711281819.XA CN201711281819A CN107998203A CN 107998203 A CN107998203 A CN 107998203A CN 201711281819 A CN201711281819 A CN 201711281819A CN 107998203 A CN107998203 A CN 107998203A
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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Abstract
The invention discloses a kind of external medicine composition and preparation method for being used to treat dyskinesia.Its bulk pharmaceutical chemicals includes the Chinese medicines such as nine Ns purple, bulbil Chinese mugwort fiber crops, manynerve bauhinia leaf, tibet lyonia branchlet, maple leaves;The present invention is compared with prior art, obvious characteristic is respectively provided with science, method, prescription, drugs, medicine, being mainly used for the paralysis caused by cerebral apoplexy (cerebral hemorrhage, cerebral infarction etc.) and encephalatrophy etc., extremity numbness, muscular atrophy, dyskinesia etc. has prevention and therapeutic effect.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, and in particular to one kind is used for caused by treating apoplexy sequela, encephalatrophy etc.
The external medicine composition and preparation method of dyskinesia.
Background technology
Cerebral apoplexy is one of principal disease of serious threat patient vitals and human health.A large amount of clinical datas discoveries,
The disability rate of cerebral apoplexy disease, case fatality rate and incidence are of a relatively high.Most patients occur after the treatment it is different degrees of after
Disease is lost, according to statistics, the different degrees of dysfunction that most apoplexy sequela patients occur, with dyskinesia the most
Common, life quality and quality of life to patient cause serious negative effect.
In recent years, improved increasingly for the treatment technology of apoplexy sequela and Brain Atrophy Patient, wherein in medicine
On it is especially more notable with the therapeutic effect of Traditional chinese medicine medicament.In the Chinese traditional treatment of apoplexy sequela, external therapy of Chinese herb is with channels and collaterals
Based on, and a large amount of clinical practices are have passed through, curative effect obtains being widely recognized as people in the industry and patient.Therefore, outside the traditional Chinese medical science
Therapy is one of main method for the treatment of apoplexy sequela at present, it can improve the profit of effective ingredient to a certain extent
With rate, it is ensured that the drug effect of medicine is brought into play to greatest extent.
Apoplexy sequela is divided into early, middle and late three phase in clinic, in its diseased later stage, it will usually due to blood stasis, phlegm wet
Stasis blocking and cause unfavorable, swelling pain of limb activity etc..When carrying out external treatment with Chinese medicine to such patient, acupuncture point, affected part massage are
One of most common method, while massage therapy is coordinated using external used medicine, i.e., controlled by the efficacy of a drug and point massage to reach
Therapeutic effect.For patients with cerebral apoplexy, in the process, medicine can make spasm muscle muscle it is loose, it is promoting blood circulation and removing obstruction in channels, exploitation hair
Hole, relaxed and comfortable spasm, promote microcirculation, improve the limbs blood supply situation of patient with this, improve the nerve and blood vessel of patient
Functional purpose.
The external used medicine of some existing cooperation massage therapies, though respectively there is the effect of certain, for dyskinesia
Patient, its treat medicine need further to excavate, make patient motion dysfunction eliminate effect strengthened and
Extension.
The content of the invention
Preferably to be cured to dyskinesia patient, its therapeutic effect is improved, the present invention proposes a kind of new
Composition of medicine of external treatment with Chinese medicine and preparation method thereof, the therapeutic effect of its medicine are higher than the other drugs used at present, can make trouble
Person recovers motor function faster.
The technical scheme is that:
A kind of external medicine composition for treating dyskinesia, including following bulk pharmaceutical chemicals:Nine Ns purple, bulbil Chinese mugwort fiber crops,
Manynerve bauhinia leaf, tibet lyonia branchlet, maple leaves, radix cyathulae, Ligusticum wallichii, Cortex Magnoliae Officinalis, pig label are careless, process and worn under complanate astragalus seed, L-Borneol, twelve two time, leaf
Pin, fringe tree bark, bright mirror grass.
Added in the bulk pharmaceutical chemicals:Angelica sinensis, safflower, radix astragali and/or corydalis tuber.
The preparation method of the external medicine composition of dyskinesia is treated, is divided into liquid spray or the liniment of spraying
Two kinds of preparation method and the preparation method of ointment.
Beneficial effects of the present invention are:
The pharmaceutical preparation of external application Chinese medicine of the present invention can be made into spray or cream, for different patients and whether
There are underlying diseases (such as hypertension), select one of which or two kinds of mutual cooperations, completed for patient with liquor massaging point
Afterwards, using cream, to consolidate and improve curative effect.We to the correlation circumstance of apoplexy sequela patient's row Chinese traditional treatment into
After row is understood in depth, observation of curative effect, significant effect, nontoxic secondary work have been carried out to controlling apoplexy sequela outside the research and development medicine
With.Compared with prior art, the present invention obvious characteristic is respectively provided with science, method, prescription, drugs, medicine, while use is easy to carry, quality is steady
It is fixed, for the paralysis caused by cerebral apoplexy (cerebral hemorrhage, cerebral infarction etc.) and encephalatrophy etc., extremity numbness, muscular atrophy, motor function barrier
Hindering etc. has significant therapeutic effect, and has prevention effect.
Embodiment
The present invention proposes a kind of external medicine composition for treating dyskinesia and preparation method thereof:
A kind of external medicine composition for treating dyskinesia, including following bulk pharmaceutical chemicals:Nine Ns purple, bulbil Chinese mugwort fiber crops,
Manynerve bauhinia leaf, tibet lyonia branchlet, maple leaves, radix cyathulae, Ligusticum wallichii, Cortex Magnoliae Officinalis, pig label are careless, process complanate astragalus seed, L-Borneol, twelve two time (also weighs
Valve clematis), thread a needle (i.e. Radix zanthoxyli) under leaf, fringe tree bark, bright mirror grass.
The parts by weight of its bulk pharmaceutical chemicals are:Nine Ns 20-40 parts purple, 10-30 parts of fiber crops of bulbil Chinese mugwort, 10-20 parts of manynerve bauhinia leaf, millet
10-20 parts of bavin, 10-20 parts of maple leaves, 8-12 parts of radix cyathulae, 8-12 parts of Ligusticum wallichii, 10-20 parts of Cortex Magnoliae Officinalis 8-12 Fen, pig label grass, process sand
Thread a needle under 8-12 parts of aster, 3-8 parts of L-Borneol, 10-14 parts of twelve two time, leaf 7-11 parts, 8-12 parts of fringe tree bark, 5-9 parts of bright mirror grass.
General patient just has the effect of being satisfied with using the preparation of above-mentioned Chinese medicine composition, but for the heavier trouble of the state of an illness
Person, to make it faster and more effectively tell on, can also add in the bulk pharmaceutical chemicals:Angelica sinensis, safflower, radix astragali and/or
Corydalis tuber.Its parts by weight is:8-12 parts of 8-12 parts of Angelica sinensis, 8-12 parts of safflower, 10-20 parts of radix astragali and/or corydalis tuber.
As better embodiment, treating the external medicine composition of dyskinesia includes the raw material of following parts by weight
Medicine:Nine Ns 30 parts purple, 20 parts of bulbil Chinese mugwort fiber crops, 15 parts of manynerve bauhinia leaf, 15 parts of tibet lyonia branchlet, 15 parts of maple leaves, 10 parts of radix cyathulae, Ligusticum wallichii
10 parts, 10 Fen, pig label of Cortex Magnoliae Officinalis grass 15 parts, process thread a needle under 10 parts of complanate astragalus seed, 5 parts of L-Borneol, 12 parts of twelve two time, leaf 9 parts, fringe tree bark
10 parts, 7 parts of bright mirror grass.
It can be added in the bulk pharmaceutical chemicals:10 parts of 10 parts of Angelica sinensis, 10 parts of safflower, 15 parts of radix astragali and/or corydalis tuber.
In pharmaceutical formulation of the present invention, the drug effect of key agents is:
It is nine Ns purple:The rhizome of Rhamnaceae platymiscium ventilago leiocarpa, record in《National Chinese herbal medicine compilation》, have nourishing the blood to expel wind,
Relaxing tendons and activating collaterals, reinforce the kidney beneficial essence and other effects;
Bright mirror grass:The herb of Umbelliferae pennywort platymiscium pennywort, head are carried《A thousand pieces of gold food therapys》, there is clearing heat and promoting diuresis, outside
Control for treating eczema, herpes zoster, have inhibitory action to staphylococcus aureus, typhoid bacillus;
Twelve two time:The root of cohosh polyphyll clematis, cures mainly apoplexy, gout;
Thread a needle under leaf:The complete stool of rutaceae Radix zanthoxyli, the qi-regulating of major function middle benefit gas, wind-dispelling promoting circulation of blood, eliminating stagnation to stop pain;
Fringe tree bark:The root of Asclepiadaceae plant radix tylophorae, major function rheumatism, traumatic injury.
The method that the external medicine composition for the treatment of dyskinesia is prepared with above-mentioned bulk pharmaceutical chemicals, is divided into liquid spray
Agent or the spray preparation method of liniment and two kinds of the preparation method of ointment.
The first, treat dyskinesia external medicine composition liquid spray or spray liniment preparation side
Method, its step are:
(1), L-Borneol is first ground into fine powder, it is spare;
(2), remaining bulk pharmaceutical chemicals is placed and carries out coarse crushing together, mixes, add weight is the 50-60 degree of 2-5 times of bulk pharmaceutical chemicals
White wine, impregnates 30-60 days under room temperature, filters, and white wine filtrate is spare;
(3), L-Borneol powder made of the step (1) is added in white wine filtrate made of step (2) and fully dissolved, made
It is liquid preparation for external application into liquid;
(4), gained liquid in step (3) is dispensed according to clinical demand by scalar, preparation method system routinely
It is standby into external use liquid spray or spraying liniment.
Secondth, the preparation method of the ointment of the external medicine composition of dyskinesia is treated, its step is:
(1), L-Borneol is ground into fine powder, it is spare;
(2), remaining bulk pharmaceutical chemicals is subjected to coarse crushing, with the ethanol as solvent of 50-65 degree, with do not cross the amount of bulk pharmaceutical chemicals by its
Soak 24 it is small when, using percolation carry out first time diacolation, flow velocity be bulk pharmaceutical chemicals weight 1-2 times/hour, collection 10-15 times
The percolate of bulk pharmaceutical chemicals weight;Again with identical with above-mentioned condition ethanol as solvent immersion bulk pharmaceutical chemicals 12 it is small when, carry out second
Diacolation, speed are same as above, and collect the percolate of 8-10 times of bulk pharmaceutical chemicals weight;It is then combined with percolate twice;
(3), L-Borneol powder is added in percolate and fully dissolved, liquid recycling ethanol, is condensed into ointment, spare;
(4), it is mixed with the Tween-80 of ointment parts by weight 2-8%, atoleine, glycerine, methyl hydroxybenzoate
Ointment bases, the use ratio arbitrary disposition of each component in the ointment bases;Above-mentioned ointment bases and ointment are mixed equal
It is even, ointment is made, discharging dispenses to obtain the final product.
In order to ensure discrimination method science of the present invention, reasonable, feasible, it is expanded on further by clinical observation on the therapeutic effect experiment
Beneficial effects of the present invention.
1st, case selection
1240 apoplexy sequela patients, derive from clinic among the people, using hemiplegia as main shower.It is wherein male
640, female 600;Cerebral infarction person 942, cerebral hemorrhage person 298;Fall ill 1 person 920, recidivist 320;It is the oldest
Person 75 years old, reckling 40 years old, average age 59 years old;Complicated hypertension person 680, complication with diabetes person 286, merges hyperlipidemia
Disease person 980;Suffering limb muscular strength situation:0 degree of muscular strength 120, I degree muscular strength 321, II degree muscular strength 359, III degree muscular strength 284
Example, vI degree muscular strength 156, v degree muscular strength 0.
2nd, diagnostic criteria
Meet State Administration of Traditional Chinese Medicine's promulgation《Chinese medical disease Standardization of diagnosis and curative effect》;CT signs make a definite diagnosis intracerebral hematoma or
Infarction lesion.
3rd, treatment method
First make the related acupuncture point of incidence, upper limb, the small of the back, lower limb etc. to patient to rub, after the completion of rubbing, then take
Appropriate amount of fluid preparation or emulsifiable paste are applied to affected part.
Both the above method is carried out at the same time, 1-3 times daily, 10 days as one therapeutic course.
Pay attention to:Pregnant woman disables;Skin allergy person, hyperpietic use in the case where doctor instructs.
4th, curative effect judging standard
With reference to State Administration of Traditional Chinese Medicine's issue《Chinese medical disease Standardization of diagnosis and curative effect》In " cerebral apoplexy efficacy evaluation " and
" stroke clinical efficacy evaluation " is formulated.
Cure:Symptom and sign disappear, and disability degree is 0 grade, can be lived on one's own life substantially;
It is effective:Symptom and sign improve, and functional impairment scoring reduces more than 21 points, and disability degree is at 1 grade~3 grades, energy
Cane action, or basic living can take care of oneself;
Effectively:Symptom and sign improvement, 8~20 points of functional impairment scoring reduction, energy cane action, or basic living can be certainly
Reason;
It is invalid:Symptom and sign are unchanged, and functional impairment scoring is reduced or increased less than 8 points.
5th, result is observed
1240 cases treat 3 courses for the treatment of, and observation result is as follows:
680 people of hypertension group:
Recovery from illness 53, effective 395, effective 198, invalid 34.Cure-remarkable-effectiveness rate 66%;Total effective rate 95%.
560 people of non-hypertensive group:
Recovery from illness 43, effective 323, effective 160, invalid 34.Cure-remarkable-effectiveness rate 65%;Total effective rate 93%.
Above clinical observation shows that Chinese medicine is embrocated can effectively facilitate suffering limb functional rehabilitation with reference to point massage, be worthy to be popularized
With.
Typical cases:
Medical record 1:Jia XX, man, 72 years old, the sweet Chinese bush cherry village people in Guizhou the west of Guizhou Province.Patient suffers from hypertension, hemiparalysis had more than 10 years, and 10
Year, cause was drunk, and cause cerebral apoplexy is senseless, and local hospital is examined as " cerebral thrombus ".Through rescue, it is unsuccessful that patient shows half body hemiplegia.Examine
Depending on:Right hemiplegia, right upper extremity cannot praise, and right lower extremity is stiff, walk difficult, dizziness and tinnitus, head piece saliva, tongue say by force it is not smoothgoing,
Five is vexed hot-tempered, and dry is drunk less, dry and hard excrement, and the short frequency of enuresis nocturna, tongue is light red, and edge purple is dim, moss thin yellow, small and wiry pulse and puckery, blood pressure:
167/97mmHg.Water files to nourish wood for card category, phlegm heat, congestion blood block channels and collaterals.Control suitable nourishing liver and kidney, clearing heat and eliminating phlegm, promoting qi circulation and removing obstruction in the collateral.This case
Cerebral thrombus, it is believed that " pathogen remaining alone, sends out to be hemiplegia ", card belong to asthenia in origin and asthenia in superficiality, control suitable soothing the liver and grow based on sun, heat clearing and blood stasis dispersing, is helped with benefit
Gas is promoting blood circulation and removing obstruction in channels, and clinical efficacy is gradually good.Spray after half an hour, spirit is still good, and blood pressure drop 132/76mmHg, upper right lower limb can live
Move freely, symptom disappears substantially, and limb function substantially recovers.
Medical record 2:Ma, man, 67 years old, Gansu people from Lanzhou, once suffered from cerebral infarction, cerebral apoplexy, salivation is more than, mouth eye
Tiltedly, language is difficult, and right side hemiplegia is powerless.Spray half an hour, smear paste daily within second and third two days, can stand after three days, it is feasible
Walk.
Medical record 3:Rhythm so-and-so, man, 55 years old.Hemiplegia, artery sclerosis, upper right numbness of lower limbs, activity is unfavorable but still can be movable, speech
Some changes of language, speak more stupid, and because labor fruit and feelings essence are bad, soldier so falls servant and falls down to the ground, and pole other people are lifted to bed, senseless, gas
Raucous breathing is big, goes through nine hours and does not regain consciousness still.Patient is addicted to drink usually, and capacity for liquor is quite big, and in the past few years often suffer from headaches dizziness, and burst half body is not
Then, the slight chatter of head hand.Spray after half an hour, patient can stand, three steps of walking, the head body chatter of 20 years also not the phase and
More.
Medical record 4:Peng so-and-so, female, 82 years old, Heze City, Shandong Province people.8 years left paralysiss.January in this year, headache suddenly, dizzy and vomiting,
Have the fidgets, unconsciousness, exhale in silence, Xiang Qiang, the micro- urgency of four limbs, headache, dizzy and vomiting, speech owes clear, left side nasolabial groove
Shoal, 15 jiaos of right sides are askew, and loll left avertence, and the drum cheek leaks out.Cardiopulmonary are normal, and 2 grades of left upper extremity muscular strength, 4 grades of left lower extremity muscular strength, gait is not
Surely, sensory system checks normal, left lower extremity Oppenheim signs (+), Gordon signs (+), Brudzinski ' s signs (+).Auxiliary inspection
Look into:Head CT shows:Right cerebral infarction.Diagnosis:Right side cerebral infarction.Previously there are more than 8 years of hypertension history, take drop blood always in recent years
Pressing thing controls blood pressure.MRI checks prompting multiple cerebral infarction.Spray after half an hour, at twice, can stand, be assisted in by people
Under can walk 20 meters.
Medical record 5:Crow so-and-so, 65 years old, Inner Mongol ancients, parkinson's syndrome, speech talk it is just unclear, eyesight is general, tongue
Slightly slight right askew, right side lower limb cannot move, and about 2-3 grades of muscular strength, right leg is almost unable to stir any more, and finger cannot live completely
It is dynamic, wheelchair, 0-1 grades of muscular strength;Appetite and sleep, stool and urine constipation.Red tongue body, tongue is few and wet, and veins string is hard.Qi and blood loses
Void, wind-yang and up-boring, brain mansion, which is become silted up, to be hindered.Spray 35 minutes, then plaster was applied twice daily in three days, it can stand, can walk 5 meters.
Medical record 6:Bai, 93 years old, Gansu people from Lanzhou, right side physical handicaps were protruded with sluggish speech, serious lumbar vertebrae keyboard,
Cranial Computed Tomography:" left temporal lobe, top cerebral infarction " is diagnosed as, right side limbs are unfavorable, and the symptom such as disfluency improves unobvious, spirit
Poor, tired, head tilted and blurred vision with staring, hemiplegia, right side limb activity is unfavorable, 2 grades of right side muscular strength, of flaccid muscles, distortion of commissure, mouth
A lot of, the pale tongue of middle salivation, tongue is thin white, and arteries and veins is thin.Spray 20 minutes, spiritual amelioration, lower-limb muscular strength is clearly better, and slobbering is obvious
Reduce.Patient's confidence increases, through one week it is secondary for several times apply the ointment, household can leave the bed walking under assisting, stride just, right side muscular strength
It is clearly better
The present invention coordinates massage therapy using external used medicine, during medication, is given and adjusted according to the specific state of an illness of patient
Whole medication, to reach optimal therapeutic effect.For patients with cerebral apoplexy, in its diseased later stage, it will usually due to blood stasis,
Retention of phlegm and dampness and cause unfavorable, swelling pain of limb activity etc..When carrying out external treatment with Chinese medicine to such patient, mainly pass through medicine
Power and point massage reach therapeutic effect, and in the process, medicine can make that spasm muscle muscle is loose, promoting blood circulation and removing obstruction in channels, exploitation
Pore, relaxed and comfortable spasm, promote microcirculation, improve the limbs blood supply situation of patient with this, improve the nerve and blood of patient
Pipe functional purpose.
The present invention derives from shui ethnicity in Guizhou (unique Shui nationality autonomous county of China) national folk really medicable proved recipe handed down from one's ancestors,
Geographical location is with being in world natural heritage in the karst virgin forest vegetation area of Jing Cheng.
Claims (7)
1. a kind of external medicine composition for treating dyskinesia, it is characterised in that including following bulk pharmaceutical chemicals:Purple nine Ns, pearl
Bud Chinese mugwort fiber crops, manynerve bauhinia leaf, tibet lyonia branchlet, maple leaves, radix cyathulae, Ligusticum wallichii, Cortex Magnoliae Officinalis, pig label are careless, process complanate astragalus seed, L-Borneol, twelve two time,
Thread a needle under leaf, fringe tree bark, bright mirror grass.
2. external medicine composition according to claim 1, it is characterised in that include the bulk pharmaceutical chemicals of following parts by weight:Purple nine
20-40 parts of ox, 10-30 parts of fiber crops of bulbil Chinese mugwort, 10-20 parts of manynerve bauhinia leaf, 10-20 parts of tibet lyonia branchlet, 10-20 parts of maple leaves, radix cyathulae
8-12 parts, 8-12 parts of Ligusticum wallichii, 10-20 parts of Cortex Magnoliae Officinalis 8-12 Fen, pig label grass, process 8-12 parts of complanate astragalus seed, 3-8 parts of L-Borneol, twelve two time
10-14 parts, thread a needle under leaf 7-11 parts, 8-12 parts of fringe tree bark, 5-9 parts of bright mirror grass.
3. external medicine composition according to claim 1, it is characterised in that include the bulk pharmaceutical chemicals of following parts by weight:Purple nine
30 parts of ox, 20 parts of bulbil Chinese mugwort fiber crops, 15 parts of manynerve bauhinia leaf, 15 parts of tibet lyonia branchlet, 15 parts of maple leaves, 10 parts of radix cyathulae, 10 parts of Ligusticum wallichii, thickness
Plain 15 parts of 10 Fen, pig label grass, process thread a needle under 10 parts of complanate astragalus seed, 5 parts of L-Borneol, 12 parts of twelve two time, leaf 9 parts, it is 10 parts of fringe tree bark, bright
7 parts of mirror grass.
4. external medicine composition according to claim 2, it is characterised in that add following weight in the bulk pharmaceutical chemicals
The bulk pharmaceutical chemicals of part:8-12 parts of 8-12 parts of Angelica sinensis, 8-12 parts of safflower, 10-20 parts of radix astragali and/or corydalis tuber.
5. external medicine composition according to claim 3, it is characterised in that add following weight in the bulk pharmaceutical chemicals
The bulk pharmaceutical chemicals of part:10 parts of 10 parts of Angelica sinensis, 10 parts of safflower, 15 parts of radix astragali and/or corydalis tuber.
6. the spray of the external medicine composition of dyskinesia is prepared with the bulk pharmaceutical chemicals described in claim 1,2,3,4 or 5
Mist agent or the method for liniment of spraying, it is characterised in that preparation process is:
(1), L-Borneol is ground into fine powder, it is spare;
(2), remaining bulk pharmaceutical chemicals to be placed and carries out coarse crushing together, mixes, add weight is the 50-60 degree white wine of 2-5 times of bulk pharmaceutical chemicals,
Impregnate 30-60 days, filter under room temperature, filtrate is spare;
(3), L-Borneol powder made of the step (1) is added in the white wine filtrate of step (2) and fully dissolved;
(4), gained liquid in step (3) is dispensed according to clinical demand by scalar, be prepared into external use liquid spray or
Spraying liniment.
7. the external medicine composition ointment of dyskinesia is prepared with the bulk pharmaceutical chemicals described in claim 1,2,3,4 or 5
The method of agent, it is characterised in that step is:
(1), L-Borneol is ground into fine powder, it is spare;
(2), remaining bulk pharmaceutical chemicals is subjected to coarse crushing, with the ethanol as solvent of 50-65 degree, is soaked with not crossing the amount of bulk pharmaceutical chemicals
24 it is small when, using percolation carry out first time diacolation, flow velocity be bulk pharmaceutical chemicals weight 1-2 times/hour, collection 10-15 times of raw material
The percolate of medicine weight;Again with identical with above-mentioned condition ethanol as solvent immersion bulk pharmaceutical chemicals 12 it is small when, carry out second of diacolation,
Speed is same as above, and collects the percolate of 8-10 times of bulk pharmaceutical chemicals weight;It is then combined with percolate twice;
(3), L-Borneol powder is added in percolate and fully dissolved, liquid recycling ethanol, is condensed into ointment, spare;
(4) it is mixed and made into ointment bases with Tween-80, atoleine, glycerine, methyl hydroxybenzoate;By above-mentioned ointment base
Matter and ointment are uniformly mixed, and ointment is made, and discharging dispenses to obtain the final product.
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Application publication date: 20180508 |