CN107982466A - A kind of Chinese medicine composition for treating fracture and preparation method thereof - Google Patents
A kind of Chinese medicine composition for treating fracture and preparation method thereof Download PDFInfo
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Classifications
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L13/00—Meat products; Meat meal; Preparation or treatment thereof
- A23L13/50—Poultry products, e.g. poultry sausages
- A23L13/52—Comminuted, emulsified or processed products; Pastes; Reformed or compressed products from poultry meat
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/57—Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9062—Alpinia, e.g. red ginger or galangal
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
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Abstract
The invention belongs to field of Chinese herbal medicine technology, more particularly to a kind of Chinese medicine composition for treating fracture and preparation method thereof, its formula of medicament prepared by the present invention is simple, and preparation method is simple, strong operability, nontoxic, edible safety, can play the effect of swelling and pain relieving, soft tissue healing and absorption of edema can be accelerated at the same time, 100% is up to the cure rate of fracture, and can effectively improve the bone density of patient, its bone density is up to 0.55g/cm in the later stage3More than.
Description
Technical field
The invention belongs to field of Chinese herbal medicine technology, more particularly to a kind of Chinese medicine composition for treating fracture and its preparation side
Method.
Background technology
Fracture is that the integrality of bone and continuity are interrupted, can be caused by wound and bone disease.In recent years, with domestic industry
The continuous improvement of change degree and increasing for vehicles type and quantity, the incidence of traumatic fracture are substantially in rising trend.
Since union needs a very long process, pain, swelling after fracture, that moving obstacle not only have impact on patient is normal
Work and life, it is also possible to because patient fears pain and not timely reconditioning, when fracture place be not easy to wrap up fixed when,
Challenge is brought to treatment, as a result causes lifelong maimed person.But at present for fracture used by treatment method be to outer mostly
Section performs the operation, and wrapping is fixed, its medical expense and its expensive, and the cycle is grown, and effect is slow.
The content of the invention
The present invention is in order to solve the above technical problems, provide a kind of Chinese medicine composition for treating fracture and its preparation side
Method.
Realized particular by following technical scheme：
A kind of Chinese medicine composition for treating fracture, including following mass parts raw material：30-60 parts of smallflower microtis herb, pseudo-ginseng 10-40
Part, 10-25 parts of galanga galangal seed, 5-15 parts of rhizome of chuanxiong, 5-10 parts of teasel root, 400-500 parts of chicken.
Further, the Chinese medicine composition of the treatment fracture, including following mass parts raw material：45-55 parts of smallflower microtis herb, three
Seven 25-37 parts, 17-22 parts of galanga galangal seed, 8-12 parts of rhizome of chuanxiong, 7-8 parts of teasel root, 450-500 parts of chicken.
Further, the smallflower microtis herb is fresh medicinal material or dried product.
Further, the chicken is black chicken meat, it is free of chicken bone.
Further, the Chinese medicine composition of the treatment fracture, including following preparation process：
1) smallflower microtis herb grinding or crushing, must expect that 1 is spare；
2) pseudo-ginseng, galanga galangal seed, rhizome of chuanxiong, teasel root mixing, crush, frying, add white wine, water mixing, stand, obtain material 2；
3) chicken is ground into meat gruel, is mixed with material 1, material 2, pepper powder, makes meatball, freezing, steams every pot, you can food
With.
Further, step 2) the addition white wine, its addition are the 7-8% of mixed-powder.
Further, step 2) is described is included in white wine, water, and final mixed powder moisture is 70-75%.
Further, the standing described in step 2), is to stand 1-2h at room temperature.
Further, the freezing described in step 3), is to handle 30-50min at 4-8 DEG C.
Further, being steamed every pot described in step 3), its steaming time is 1.8-2.2h.
Beneficial effect, compared with prior art, the present invention haing the following advantages：
1) its formula of medicament prepared by the present invention is simple, and preparation method is simple, strong operability, nontoxic, and edible safety, passes through
Zoopery finds, fracture collagenous fibres and normal periosteum no significant difference after animal edible medicine 30 days, without obvious soft
Osteocyte is connected with braiding bon e formation bone, and woven bone fundamental transformation can improve the content of calcium in rat body, increase into lamellar bone
The absorption of strong calcium ability, is effectively increased calcium content of bone and forms bone calcium, strengthens calcium constituent and absorbs, promotes the recovery from illness of bone.
2) clinical practice is found：The medicine for the treatment of fracture prepared by the present invention can play the effect of swelling and pain relieving, at the same time
It can accelerate soft tissue healing and absorption of edema, 100% is up to the cure rate of fracture, and can effectively improve the bone of patient
Density, its bone density is up to 0.55g/cm in the later stage3More than.
3) medicine for the treatment fracture that the present invention obtains, in the affected part for inconvenience wrapping, can not have to wrapping, you can reach
Good therapeutic effect, solves since some grieved positions are not easy to wrap up, treatment difficulty is big, recovers slow problem.
Embodiment
The embodiment of the present invention is described in further detail below, but the invention is not limited in these realities
Mode is applied, any improvement or replacement on the present embodiment essence spirit, it is claimed to still fall within the claims in the present invention
Scope.
Embodiment 1
A kind of Chinese medicine composition for treating fracture, including following mass parts raw material：Smallflower microtis herb 30g, pseudo-ginseng 10g, galanga galangal seed
10g, rhizome of chuanxiong 5g, teasel root 5g, chicken 400g.
The smallflower microtis herb is fresh medicinal material or dried product.
The chicken is black chicken meat, it is free of chicken bone.
The Chinese medicine composition of the treatment fracture, including following preparation process：
1) smallflower microtis herb grinding or crushing, must expect that 1 is spare；
2) pseudo-ginseng, galanga galangal seed, rhizome of chuanxiong, teasel root mixing, crush, frying, add white wine, water mixing, stand, obtain material 2；
3) chicken is ground into meat gruel, is mixed with material 1, material 2, pepper powder, makes meatball, freezing, steams every pot, you can food
With.
Step 2) the addition white wine, its addition are the 7% of mixed-powder.
Step 2) is described to be included in white wine, water, and final mixed powder moisture is 70%.
Standing described in step 2), is to stand 1h at room temperature.
Freezing described in step 3), is to handle 30min at 4 DEG C.
Being steamed every pot described in step 3), its steaming time is 1.8h.
Embodiment 2
A kind of Chinese medicine composition for treating fracture, including following mass parts raw material：Smallflower microtis herb 45g, pseudo-ginseng 25g, galanga galangal seed
17g, rhizome of chuanxiong 8g, teasel root 7g, chicken 450g.
The smallflower microtis herb is fresh medicinal material or dried product.
The chicken is black chicken meat, it is free of chicken bone.
The Chinese medicine composition of the treatment fracture, including following preparation process：
1) smallflower microtis herb grinding or crushing, must expect that 1 is spare；
2) pseudo-ginseng, galanga galangal seed, rhizome of chuanxiong, teasel root mixing, crush, frying, add white wine, water mixing, stand, obtain material 2；
3) chicken is ground into meat gruel, is mixed with material 1, material 2, pepper powder, makes meatball, freezing, steams every pot, you can food
With.
Step 2) the addition white wine, its addition are the 7.5% of mixed-powder.
Step 2) is described to be included in white wine, water, and final mixed powder moisture is 73%.
Standing described in step 2), is to stand 1.2h at room temperature.
Freezing described in step 3), is to handle 40min at 6 DEG C.
Being steamed every pot described in step 3), its steaming time is 2.0h.
Embodiment 3
A kind of Chinese medicine composition for treating fracture, including following mass parts raw material：Smallflower microtis herb 55g, pseudo-ginseng 37g, galanga galangal seed
22g, rhizome of chuanxiong 12g, teasel root 8g, chicken 500g.
The smallflower microtis herb is fresh medicinal material or dried product.
The chicken is black chicken meat, it is free of chicken bone.
The Chinese medicine composition of the treatment fracture, including following preparation process：
1) smallflower microtis herb grinding or crushing, must expect that 1 is spare；
2) pseudo-ginseng, galanga galangal seed, rhizome of chuanxiong, teasel root mixing, crush, frying, add white wine, water mixing, stand, obtain material 2；
3) chicken is ground into meat gruel, is mixed with material 1, material 2, pepper powder, makes meatball, freezing, steams every pot, you can food
With.
Step 2) the addition white wine, its addition are the 8% of mixed-powder.
Step 2) is described to be included in white wine, water, and final mixed powder moisture is 75%.
Standing described in step 2), is to stand 2h at room temperature.
Freezing described in step 3), is to handle 50min at 8 DEG C.
Being steamed every pot described in step 3), its steaming time is 2.2h.
Embodiment 4
A kind of Chinese medicine composition for treating fracture, including following mass parts raw material：Smallflower microtis herb 60g, pseudo-ginseng 40g, galanga galangal seed
25g, rhizome of chuanxiong 15g, teasel root 10g, chicken 500g.
The smallflower microtis herb is fresh medicinal material or dried product.
The chicken is black chicken meat, it is free of chicken bone.
The Chinese medicine composition of the treatment fracture, including following preparation process：
1) smallflower microtis herb grinding or crushing, must expect that 1 is spare；
2) pseudo-ginseng, galanga galangal seed, rhizome of chuanxiong, teasel root mixing, crush, frying, add white wine, water mixing, stand, obtain material 2；
3) chicken is ground into meat gruel, is mixed with material 1, material 2, pepper powder, makes meatball, freezing, steams every pot, you can food
With.
Step 2) the addition white wine, its addition are the 8% of mixed-powder.
Step 2) is described to be included in white wine, water, and final mixed powder moisture is 75%.
Standing described in step 2), is to stand 2h at room temperature.
Freezing described in step 3), is to handle 50min at 8 DEG C.
Being steamed every pot described in step 3), its steaming time is 2.2h.
Embodiment 5-12 formula compositions are as shown in table 1, and its preparation method is same as Example 2.
1 embodiment 5-12 composition of raw materials of table forms
| Smallflower microtis herb | Pseudo-ginseng | Galanga galangal seed | Rhizome of chuanxiong | Teasel root | Chicken | |
| Embodiment 5 | - | 25g | 17g | 8g | 7g | 450g |
| Embodiment 6 | 45g | - | 17g | 8g | 7g | 450g |
| Embodiment 7 | 45g | 25g | - | - | 7g | 450g |
| Embodiment 8 | 45g | 25g | 17g | 8g | - | 450g |
| Embodiment 9 | 45g | 25g | 17g | 8g | 7g | 450g |
| Embodiment 10 | 75g | 25g | 17g | 8g | 15g | 450g |
| Embodiment 11 | 45g | 5g | 5g | 8g | 7g | 450g |
| Embodiment 12 | 20g | 25g | 17g | 8g | 20g | 450g |
Embodiment 13
13 raw material of embodiment composition it is same as Example 2, its preparation method be by smallflower microtis herb, pseudo-ginseng, galanga galangal seed, rhizome of chuanxiong,
Teasel root mixes, and crushes, mixes, cook with muscle, pepper powder.
Embodiment 14
The formula composition of embodiment 14 is same as Example 2, and in step 2) the addition white wine, its addition is mixed powder
The 14% of end.
Embodiment 15
The formula composition of embodiment 15 is same as Example 2, preparation process 3) do not include freezing processing.
Experimental example
1st, toxotest
Experimental method：Select Kunming mouse male and female each 160 (18.0-22.0g), be divided into 16 groups, 1-15 groups, which are fed, to be implemented
Medicine prepared by example 1-15,16 groups are fed blank chicken, fasting 16h before experiment, not water restriction for control group.Sample sets 30.0g/
One dosage group of kg weight.To observation post administrations 1 week, poisoning manifestations and death condition are recorded, judges its maximal tolerance dose (MTD),
Its acute toxicity power is evaluated by toxicity grading standard.
Experimental result：During the experiment animal action is flexible, and reaction is quick, and hair is clean and tidy, lustrous eyes, and eye muzzle is without secretion
Thing, feed drinking-water is normal, and growth and development is good, is showed no obvious toxic reaction, none death.Male and female its mouse oral MTD is big
In 30.0g/kg weight, belong to nontoxic level.
2nd, zoopery
SPF grades of Wistar rats, half male and half female, totally 360, weight is 200 ± 20g, is divided into 18 groups, experimental group 1-
Chicken dumpling made of glutinous rice flour prepared by 15 edible embodiment 1-15,16 groups are taken application number CN201310355378.9 for control group《Synthetism
Medicine》, 17 groups are model group, and 18 groups are blank control group.
10% chloraldurate 3mL/kg is injected intraperitoneally to anaesthetize rat, after it is anesthetized completely, is fixed in
Aseptic operation table, carries out cropping at left fore, with scalpel by incision of skin, separates and removes muscle and connective tissue, use
The radius of 7 groups of rats is caused to fracture by bone forceps, except blank control group, by operation suture thread in wound layer-by-layer suture notch,
I.e. modeling is completed, and observes its dynamic, is carried out disinfection in time with 75% medicinal alcohol during operation and is cleared up wound.Postoperative company
Continuous 3d, the gentamicin that 40,000 units are injected intraperitoneally carries out anti-inflammation and sterilization to fracture rat, and is disappeared to its wound with Iodophor
Poison.Feed and drinking-water are normally given daily, and replaces bedding and padding, keeps its living environment clean.Operation consent carries out disinfection sterilization, makes
It is maintained in whole operating room in gnotobasis, and is periodically cleaned, sterilized, divulged information, avoids wound infection.
Wistar rats are placed in no-special pathogen rank, environment temperature is maintained at 20-22 DEG C, relative humidity 60%
Zoopery room in, and half male and half female divides cage to place, normal to raise Adaptable growth 7 days, allows its basis of freely ingesting
Feed and water, every rat is marked with picric acid respectively.
Dosage：Dosage is 2g/100g, is fed once daily, and daystart is fed after modeling, in administration 10
My god, according to method (textual criticism of Wang Xin space purple sesames Herbal Textuals, set a broken bone effect and chemical constitution study [D] Jis of document report
Woods agriculture university, 2016.) sampled and coherent detection.Blank control group and model control group give same amount of chicken, give
Pharmaceutical quantities are 2g/100g.
Operated more than, carry out 3 experiments.
Experimental result：Imageological examination experimental rat postop fracture situation, passes through x ray photograph after experimental rat operation
Position observation confirms the fracture of radius position modeling success of 16 groups of rats, and x ray photograph shows that in addition to blank control group remaining 16
The visible radius fracture of group, bone amount are largely lost, and fracture line is substantially clear, and subperiosteal hemorrhage and its surrounding connective tissue occur to swell
Swollen, radius damage is obvious, fracture rates 100%.
Related Component changes of contents in 2 serum of table
Medicament prepared by embodiment 1-4, finds after being administered 30 days, and fracture collagenous fibres are with normal periosteum without obvious poor
Different, no obvious cartilage cell connects with braiding bon e formation bone, and woven bone fundamental transformation is into lamellar bone, and other embodiment is recovered
It is poor, it is fast without embodiment 1-3.In addition, found by recipe determination, embodiment 1-4 after administration 30 days, Determination of Calcium in Serum,
The content of phosphorus is apparently higher than control group and other embodiment.The apatite being made of calcium and phosphorus is present in bone, is to promote bone
An important factor for bone, illustrate that embodiment 1-4 groups are best to the ability effect of bone healing, can improve containing for calcium in rat body
Amount, strengthens the absorption of calcium ability, is effectively increased calcium content of bone and forms bone calcium, strengthens calcium constituent and absorbs, promotes the recovery from illness of bone.
3rd, clinical practice
The medicament prepared using embodiment 2 carries out clinical treatment, chooses fracture patient 80, is randomly divided into two groups, 1 group of clothes
Fixed with the medicine of embodiment 2, and without wrapping up, 2 groups are taken application number CN201310355378.9《Showy reiolaena root-bark》, take
Dosage is according to the progress provided in patent, and the dosage that embodiment 2 provides is the dosage of 3 days, drug administration one month.Compare two groups
The pretherapy and post-treatment symptom integral of patient, clinical therapeutic efficacy and fracture early stage, mid-term, late period pain condition, bone density.Wherein early stage
For in after by wound 2 weeks, to fracture 2-5 weeks, late period is more than 5 weeks mid-term for the fracture time.Method (the text of reference literature report
Application [J] present age medical collection of essay of the river activating blood and removing stasis drugs in terms for the treatment of in the morning, afternoon and evening phase fracture, 2012,10 (10):72-
73.) detection of relevant parameter is carried out.
Curative effect judging standard：Recovery from illness：After treatment, the symptom such as pain and swelling disappears, and joint function recovery is normal；It is aobvious
Effect：The symptom such as pain and swelling disappears, and function of joint improvement is notable；Effectively：The symptom such as pain and swelling has changed
Kind, function of joint has improved；It is invalid：Any change does not occur for the symptom such as pain and swelling, and function of joint is without improvement.
3 Clinical efficacy comparison of table
| Recovery from illness | It is effective | Effectively | It is invalid | Total effective rate | |
| Embodiment 2 | 21 | 15 | 3 | 0 | 100% |
| Control group | 7 | 10 | 13 | 10 | 75% |
4 bone density of table compares (g/cm3)
| In early days | Mid-term | Late period | |
| Embodiment 2 | 0.51 | 0.53 | 0.57 |
| Control group | 0.31 | 0.34 | 0.38 |
Found by clinical trial, the medicine for the treatment of fracture prepared by the present invention can play the effect of swelling and pain relieving, together
When can accelerate soft tissue healing and absorption of edema, 100% is up to the cure rate of fracture, and can effectively improve patient's
Bone density, its bone density is up to 0.55g/cm in the later stage3More than.
Claims (10)
1. a kind of Chinese medicine composition for treating fracture, it is characterised in that including following mass parts raw material：30-60 parts of smallflower microtis herb, three
Seven 10-40 parts, 10-25 parts of galanga galangal seed, 5-15 parts of rhizome of chuanxiong, 5-10 parts of teasel root, 400-500 parts of chicken.
2. the Chinese medicine composition for the treatment of fracture as claimed in claim 1, it is characterised in that the Chinese medicine group of the treatment fracture
Compound, including following mass parts raw material：It is 45-55 parts of smallflower microtis herb, 25-37 parts of pseudo-ginseng, 17-22 parts of galanga galangal seed, 8-12 parts of rhizome of chuanxiong, continuous
Break 7-8 parts, 450-500 parts of chicken.
3. the Chinese medicine composition for the treatment of fracture as claimed in claim 1 or 2, it is characterised in that the smallflower microtis herb is fresh
Medicinal material or dried product.
4. the Chinese medicine composition for the treatment of fracture as claimed in claim 1 or 2, it is characterised in that the chicken is black-bone chicken
Meat, it is free of chicken bone.
5. the Chinese medicine composition for the treatment of fracture as claimed in claim 1, it is characterised in that the Chinese medicine group of the treatment fracture
Compound, including following preparation process：
1) smallflower microtis herb grinding or crushing, must expect that 1 is spare；
2) pseudo-ginseng, galanga galangal seed, rhizome of chuanxiong, teasel root mixing, crush, frying, add white wine, water mixing, seal, stand, obtain material 2；
3) chicken is ground into meat gruel, is mixed with material 1, material 2, pepper powder, makes meatball, freezing, steams every pot, you can edible.
6. the Chinese medicine composition for the treatment of fracture as claimed in claim 5, it is characterised in that step 2) the addition white wine, its
Addition is the 7-8% of mixed-powder.
7. the Chinese medicine composition for the treatment of fracture as claimed in claim 5, it is characterised in that step 2) is described to be included in white wine, water,
Final mixed powder moisture is 70-75%.
8. the Chinese medicine composition for the treatment of fracture as claimed in claim 5, it is characterised in that the standing described in step 2), be
1-2h is stood at room temperature.
9. the Chinese medicine composition for the treatment of fracture as claimed in claim 5, it is characterised in that the freezing described in step 3), be
4-8 DEG C of processing 30-50min.
10. the Chinese medicine composition for the treatment of fracture as claimed in claim 5, it is characterised in that being steamed every pot described in step 3), its
The steaming time is 1.8-2.2h.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1433767A (en) * | 2003-02-24 | 2003-08-06 | 江苏省药物研究所 | Active extracted composition of teasel root and notoginseng and use in medicine |
| CN104208173A (en) * | 2013-05-29 | 2014-12-17 | 纳米及先进材料研发院有限公司 | Chinese herbal medicine composition, nanometer emulsion and transdermal patch, and preparation thereof and purpose for traumatic injury therapy |
-
2017
- 2017-12-27 CN CN201711448142.4A patent/CN107982466A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1433767A (en) * | 2003-02-24 | 2003-08-06 | 江苏省药物研究所 | Active extracted composition of teasel root and notoginseng and use in medicine |
| CN104208173A (en) * | 2013-05-29 | 2014-12-17 | 纳米及先进材料研发院有限公司 | Chinese herbal medicine composition, nanometer emulsion and transdermal patch, and preparation thereof and purpose for traumatic injury therapy |
Non-Patent Citations (1)
| Title |
|---|
| 姚振生: "《浙江药用植物资源志要》", 31 December 2016 * |
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Application publication date: 20180504 |