CN107970522A - A kind of degradable metal base subcutaneously carries embedding thing of medicine and preparation method thereof - Google Patents
A kind of degradable metal base subcutaneously carries embedding thing of medicine and preparation method thereof Download PDFInfo
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- CN107970522A CN107970522A CN201711195316.0A CN201711195316A CN107970522A CN 107970522 A CN107970522 A CN 107970522A CN 201711195316 A CN201711195316 A CN 201711195316A CN 107970522 A CN107970522 A CN 107970522A
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- medicine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0069—Devices for implanting pellets, e.g. markers or solid medicaments
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2207/00—Methods of manufacture, assembly or production
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/04—Skin
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Abstract
A kind of degradable metal base subcutaneously carries embedding thing of medicine and preparation method thereof, it is related to a kind of subdermal implants and preparation method thereof.The purpose of the present invention is to solve existing long term injections administration inconvenience, excessive blood medicine peak value at medication initial stage, forget the problems such as medication.The embedding thing of the present invention is made of medicine and the metal based alloys pipe for accommodating medicine.Preparation process：Preparation is uniformly distributed foraminate metal based alloys pipe, compo pipe outer wrapping dialysis film layer or antiseepage film layer；By its one end adhesive of medical sealing；Load medicine from the other end；By other end adhesive of medical sealing.The degradable metal base of the present invention subcutaneously carries the embedding thing of medicine, has release drug substance stable, medicine can be made to maintain relative constant minimum level of significance in vivo, while can degrade in vivo, does not produce harmful effect to body, second operation can be avoided to bring injury.
Description
Technical field
The present invention relates to a kind of subdermal implants and preparation method thereof.
Background technology
Subdermal implants are drug application slow-released systems, i.e., medicine slowly discharges after single administration, medicine is tieed up in vivo
Hold in relative constant minimum level of significance, can both remain long-acting, avoid bad caused by medication excessive blood medicine peak value at initial stage
Reaction, and the first pass effect of liver metabolism can be avoided passing through, while reduce the adverse consequences brought because forgetting medication.
Compared to polymer, metal material because of its higher intensity and good toughness in hard tissue repairs such as Orthopeadic Surgerys and
Intervene blood vessel diagnosis and treatment etc. and obtain extensive use.Traditional medical metal material such as cochrome, stainless steel etc., though implant
It is inert presence after interior, but it is long-term or be left permanently in vivo, it is lasting to stimulate military service position, it will to cause the biologies such as chronic inflammation
Knowledge is inscribed.And voluntarily degraded after set treatment purpose is completed by the medical instrument that degradable metal material makes, not for a long time
Retain, the biology inflammatory reaction that long-term existence triggers in vivo of permanent metal implant can be avoided, can also avoid secondary hand
The risk and expense that art is brought, and catabolite is metabolizable, has no toxic side effect.
Chinese patent application publication No. provides a kind of compound Lamotrigine subdermal implantation for the patent of 103989685 A of CN
Sustained release glue stick, Chinese patent application publication No. provide a kind of compound Olanzapine skin subdermal implantation for the patent of 103877005 A of CN
Sustained release agent and Chinese patent Authorization Notice No. provide a kind of antipsychotics subdermal implantation for the patent of 202409548 U of CN
Bar device is sustained, is respectively provided with treatment and the relevant symptom of mental disease, but the slow-release material such as described glue stick is medical silicone tube or thin
Film, in body the problem of non-degradable, needs second operation to take out after insoluble drug release.
Chinese patent application publication No. provides a kind of mifepristone implants, Chinese patent for the patent of 1864689 A of CN
Application publication number provides a kind of preparation method of insulin subdermal implantation long-acting slow-release preparation for the patent of 101612390 A of CN
And Chinese patent application publication No. provides a kind of biodegradation for long-acting decompression subcutaneously for the patent of 104147606 A of CN
Heeling-in rod, it just has the effect for the treatment of endometriosis, diabetes and hypertension respectively, but the material used in it is poly- breast
The problem of polymeric materials such as acid, polylactide, caused insoluble drug release is unstable by force there are mechanical property.
The content of the invention
The purpose of the present invention is to solve existing long term injections administration inconvenience, excessive blood medicine peak value at medication initial stage, forget
The problems such as medication, and provide a kind of subdermal implants.
A kind of degradable metal base of the present invention subcutaneously carries the embedding thing of medicine, and it is embedding that the degradable metal base subcutaneously carries medicine
Thing is made of medicine and the metal based alloys pipe for accommodating medicine；Wherein, the metal based alloys pipe both ends are glued with medical
Mixture sealing, compo pipe are equipped with equally distributed aperture, compo pipe outer wrapping dialysis film layer or antiseepage film layer.
A kind of degradable metal base of the present invention subcutaneously carries the preparation method of the embedding thing of medicine, it is to follow the steps below
's：
First, prepare and be uniformly distributed foraminate metal based alloys pipe；
2nd, by the adhesive of medical sealing of metal based alloys pipe one end；
3rd, medicine is loaded from the metal based alloys pipe other end；
4th, by the adhesive of medical sealing of the metal based alloys pipe other end；
Wherein, the hole diameter described in step 1 is 0.001~0.1mm.
The degradable metal base of the present invention subcutaneously carries the embedding thing of medicine, has release drug substance stable, can make medicine in vivo
Relative constant minimum level of significance is maintained, while can be degraded in vivo, harmful effect is not produced to body, second operation can be avoided
Bring injury.
The present invention includes following beneficial effect：
The degradable metal base of the present invention subcutaneously carries the embedding thing of medicine, has degradability, can be matched according to alloy material
Regulate and control degradation time, while after insoluble drug release, can be to avoid the injury that second operation is brought.
The degradable metal base of the present invention subcutaneously carries the embedding thing of medicine, has certain mechanical property, can bear surrounding tissue
It is extruded and indeformable, guarantee drug substance stable release, medicine can be made to maintain relative constant minimum level of significance in vivo.
The degradable metal base of the present invention subcutaneously carries the embedding thing of medicine, has good biocompatibility, can reduce to body
Injury.
The degradable metal base of the present invention subcutaneously carries the embedding thing of medicine, can be different according to institute's powder charge thing, with suitable for treatment
Hypertension, diabetes, keep away mental disease and contraception.
The metal based alloys pipe mechanical strength of the present invention is reached up to 180MPa~250MPa, insoluble drug release release in 10 months
90%.
Brief description of the drawings
Fig. 1 is the structure diagram that a kind of degradable metal base of the present invention subcutaneously carries the embedding thing of medicine；Wherein, 1 is compo pipe,
2 be medicine, and 3 be aperture, and 4 be adhesive of medical sealing end, and 5 be dialysis film layer or antiseepage film layer.
Embodiment
Embodiment one：Illustrate present embodiment with reference to Fig. 1, a kind of degradable metal base of present embodiment is subcutaneous
The embedding thing of medicine is carried, the degradable metal base subcutaneously carries the embedding thing of medicine by medicine and the metal based alloys pipe for accommodating medicine
It is made；Wherein, the metal based alloys pipe both ends adhesive of medical sealing, compo pipe are equipped with equally distributed aperture,
Compo pipe outer wrapping dialysis film layer or antiseepage film layer.
Embodiment two：Illustrate present embodiment, present embodiment and one difference of embodiment with reference to Fig. 1
It is：The metal based alloys tubing matter is medical metal alloy.It is other identical with embodiment one.
Embodiment three：Illustrate present embodiment, present embodiment and one difference of embodiment with reference to Fig. 1
It is：The metal alloy is magnesium alloy or kirsite.
It is other identical with embodiment one.
Embodiment four：Illustrate present embodiment, present embodiment and one difference of embodiment with reference to Fig. 1
It is：The alloy length of tube is 10~100mm, and internal diameter is 1~10mm, and pipe thickness is 0.1mm~1mm.
It is other identical with embodiment one.
Embodiment five：Illustrate present embodiment, present embodiment and one difference of embodiment with reference to Fig. 1
It is：The alloy length of tube is 30~100mm, and internal diameter is 2~10mm, and pipe thickness is 0.3mm~1mm.
It is other identical with embodiment one.
Embodiment six：Illustrate present embodiment, present embodiment and one difference of embodiment with reference to Fig. 1
It is：The alloy length of tube is 30~80mm, and internal diameter is 2~6mm, and pipe thickness is 0.3mm~5mm.
It is other identical with embodiment one.
Embodiment seven：Illustrate present embodiment, present embodiment and one difference of embodiment with reference to Fig. 1
It is：The medicine suppresses medicine for hypertension, diabetes suppress medicine, antipsychotics or contraceptive.
It is other identical with embodiment one.
Embodiment eight：Illustrate present embodiment with reference to Fig. 1, a kind of degradable metal base of present embodiment subcutaneously carries
The preparation method of the embedding thing of medicine, it is followed the steps below：
First, prepare and be uniformly distributed foraminate metal based alloys pipe；
2nd, by the adhesive of medical sealing of metal based alloys pipe one end；
3rd, medicine is loaded from the metal based alloys pipe other end；
4th, by the adhesive of medical sealing of the metal based alloys pipe other end；
Wherein, the hole diameter described in step 1 is 0.001~0.1mm.
Embodiment nine：Illustrate present embodiment, present embodiment and one difference of embodiment with reference to Fig. 1
It is：Metal based alloys tube preparation method in step 1 is as follows：
Thin-walled thin footpath tubing is made through hot extrusion-drawing in alloy cast ingot, wherein alloy length of tube is 10~100mm, interior
Footpath is 1~10mm, and pipe thickness is 0.1mm~1mm；Be uniformly arranged aperture on tubing, compo pipe outer wrapping dialysis film layer or
Antiseepage film layer.
It is other identical with embodiment eight.
Embodiment ten：Illustrate present embodiment, present embodiment and one difference of embodiment with reference to Fig. 1
It is：The powder charge process of step 3 is as follows：
Room temperature, normal pressure, it is sterile under conditions of, by hypertension suppress medicine, diabetes suppress medicine, antipsychotics
Or contraceptive is fitted into the metal based alloys pipe of one end sealing made from step 2.
It is other identical with embodiment eight.
Present invention is not limited only to the content of the respective embodiments described above, the group of one of them or several embodiments
Contract sample can also realize the purpose of invention.
Beneficial effects of the present invention are verified by following embodiments：
Embodiment 1
A kind of degradable metal base of the present embodiment subcutaneously carries the embedding thing of medicine by the medicine of therapeutically effective amount and for accommodating
The metal based alloys pipe composition of medicine；Wherein, the metal based alloys pipe base material is pharmaceutically acceptable metal alloy,
Both ends adhesive of medical sealing, has aperture, metal based alloys pipe outer wrapping dialysis film layer on metal based alloys pipe.The medicine
Thing suppresses medicine for hypertension, and the base material of the compo pipe is the magnesium alloy that pharmaceutically acceptable can degrade in vivo.
The preparation method that a kind of degradable metal base of the present embodiment subcutaneously carries the embedding thing of medicine is to follow the steps below
's：
(1) prepare and carry foraminate compo pipe：Thin-walled thin footpath tubing is made through hot extrusion-drawing in alloy cast ingot, wherein,
Alloy length of tube is 80mm, internal diameter 6mm, pipe thickness 0.5mm.It is uniformly distributed aperture on compo pipe, distance between aperture
Determined by contained medicament categories and dosage.Compo pipe outer wrapping dialysis film layer or antiseepage film layer.
(2) by the adhesive of medical sealing of compo pipe one end：By compo pipe one end medical adhesive obtained by step (1)
Agent sealing；
(3) medicine is loaded：Room temperature, normal pressure, it is sterile under conditions of, by hypertension suppress medicine load step (2) be made
One end sealing compo pipe in；
(4) by the adhesive of medical sealing of the compo pipe other end：By the other end of the compo pipe of step (3) canned medicine
With adhesive of medical sealing, sterilizing, the embedding thing of medicine is subcutaneously carried up to degradable metal base.
Wherein, the hole diameter described in step (1) is 0.01mm.
The degradable metal base of the present embodiment subcutaneously carries the embedding thing of medicine, has degradability, can be according to alloy material
Proportioning regulation and control degradation time, while after insoluble drug release, can be to avoid the injury that second operation is brought.
The degradable metal base of the present embodiment subcutaneously carries the embedding thing of medicine, has certain mechanical property, can bear surrounding
Tissue extrudes it and indeformable, guarantee drug substance stable release, and medicine can be made to remain relative constant minimum effective in vivo
It is horizontal.
The degradable metal base of the present embodiment subcutaneously carries the embedding thing of medicine, has good biocompatibility, can reduce pair
The injury of body.
The degradable metal base of the present embodiment subcutaneously carries the embedding thing of medicine, suitable for treating hypertension.
Embodiment 2
A kind of degradable metal base of the present embodiment subcutaneously carries the embedding thing of medicine by the medicine of therapeutically effective amount and for accommodating
The metal based alloys pipe composition of medicine；Wherein, the metal based alloys pipe base material is pharmaceutically acceptable metal alloy,
Both ends adhesive of medical sealing, has aperture, metal based alloys pipe outer wrapping dialysis film layer on metal based alloys pipe.The medicine
Thing suppresses medicine for diabetes, and the base material of the compo pipe is the kirsite that pharmaceutically acceptable can degrade in vivo.
The preparation method that a kind of degradable metal base of the present embodiment subcutaneously carries the embedding thing of medicine is to follow the steps below
's：
(1) prepare and carry foraminate compo pipe：Thin-walled thin footpath tubing is made through hot extrusion-drawing in alloy cast ingot, wherein,
Alloy length of tube is 50mm, internal diameter 4mm, pipe thickness 0.8mm.It is uniformly distributed aperture on compo pipe, distance between aperture
Determined by contained medicament categories and dosage.Compo pipe outer wrapping dialysis film layer or antiseepage film layer.
(2) by the adhesive of medical sealing of compo pipe one end：By compo pipe one end medical adhesive obtained by step (1)
Agent sealing；
(3) medicine is loaded：Room temperature, normal pressure, it is sterile under conditions of, by diabetes suppress medicine load step (2) be made
One end sealing compo pipe in；
(4) by the adhesive of medical sealing of the compo pipe other end：By the other end of the compo pipe of step (3) canned medicine
With adhesive of medical sealing, sterilizing, the embedding thing of medicine is subcutaneously carried up to degradable metal base.
Wherein, the hole diameter described in step (1) is 0.05mm.
The degradable metal base of the present embodiment subcutaneously carries the embedding thing of medicine, has degradability, can be according to alloy material
Proportioning regulation and control degradation time, while after insoluble drug release, can be to avoid the injury that second operation is brought.
The degradable metal base of the present embodiment subcutaneously carries the embedding thing of medicine, has certain mechanical property, can bear surrounding
Tissue extrudes it and indeformable, guarantee drug substance stable release, and medicine can be made to remain relative constant minimum effective in vivo
It is horizontal.
The degradable metal base of the present embodiment subcutaneously carries the embedding thing of medicine, has good biocompatibility, can reduce pair
The injury of body.
The degradable metal base of the present embodiment subcutaneously carries the embedding thing of medicine, suitable for treating diabetes.
Embodiment 3
A kind of degradable metal base of the present embodiment subcutaneously carries the embedding thing of medicine by the medicine of therapeutically effective amount and for accommodating
The metal based alloys pipe composition of medicine；Wherein, the metal based alloys pipe base material is pharmaceutically acceptable metal alloy,
Both ends adhesive of medical sealing, has aperture, metal based alloys pipe outer wrapping dialysis film layer on metal based alloys pipe.The medicine
Thing is antipsychotics, and the base material of the compo pipe is the kirsite that pharmaceutically acceptable can degrade in vivo.
The preparation method that a kind of degradable metal base of the present embodiment subcutaneously carries the embedding thing of medicine is to follow the steps below
's：
(1) prepare and carry foraminate compo pipe：Thin-walled thin footpath tubing is made through hot extrusion-drawing in alloy cast ingot, wherein,
Alloy length of tube is 40mm, internal diameter 2mm, pipe thickness 0.6mm.It is uniformly distributed aperture on compo pipe, distance between aperture
Determined by contained medicament categories and dosage.Compo pipe outer wrapping dialysis film layer or antiseepage film layer.
(2) by the adhesive of medical sealing of compo pipe one end：By compo pipe one end medical adhesive obtained by step (1)
Agent sealing；
(3) medicine is loaded：Room temperature, normal pressure, it is sterile under conditions of, it is obtained that antipsychotics is loaded into step (2)
In the compo pipe of one end sealing；
(4) by the adhesive of medical sealing of the compo pipe other end：By the other end of the compo pipe of step (3) canned medicine
With adhesive of medical sealing, sterilizing, the embedding thing of medicine is subcutaneously carried up to degradable metal base.
Wherein, the hole diameter described in step (1) is 0.008mm.
The degradable metal base of the present embodiment subcutaneously carries the embedding thing of medicine, has degradability, can be according to alloy material
Proportioning regulation and control degradation time, while after insoluble drug release, can be to avoid the injury that second operation is brought.
The degradable metal base of the present embodiment subcutaneously carries the embedding thing of medicine, has certain mechanical property, can bear surrounding
Tissue extrudes it and indeformable, guarantee drug substance stable release, and medicine can be made to remain relative constant minimum effective in vivo
It is horizontal.
The degradable metal base of the present embodiment subcutaneously carries the embedding thing of medicine, has good biocompatibility, can reduce pair
The injury of body.
The degradable metal base of the present embodiment subcutaneously carries the embedding thing of medicine, suitable for treating mental disease.
Embodiment 4
A kind of degradable metal base of the present embodiment subcutaneously carries the embedding thing of medicine by the medicine of therapeutically effective amount and for accommodating
The metal based alloys pipe composition of medicine；Wherein, the metal based alloys pipe base material is pharmaceutically acceptable metal alloy,
Both ends adhesive of medical sealing, has aperture, metal based alloys pipe outer wrapping dialysis film layer on metal based alloys pipe.The medicine
Thing is contraceptive, and the base material of the compo pipe is the magnesium alloy that pharmaceutically acceptable can degrade in vivo.
The preparation method that a kind of degradable metal base of the present embodiment subcutaneously carries the embedding thing of medicine is to follow the steps below
's：
(1) prepare and carry foraminate compo pipe：Thin-walled thin footpath tubing is made through hot extrusion-drawing in alloy cast ingot, wherein,
Alloy length of tube is 60mm, internal diameter 7mm, pipe thickness 0.7mm.It is uniformly distributed aperture on compo pipe, distance between aperture
Determined by contained medicament categories and dosage.Compo pipe outer wrapping dialysis film layer or antiseepage film layer.
(2) by the adhesive of medical sealing of compo pipe one end：By compo pipe one end medical adhesive obtained by step (1)
Agent sealing；
(3) medicine is loaded：Room temperature, normal pressure, it is sterile under conditions of, contraceptive is loaded into an end seal made from step (2)
Solid compo pipe in；
(4) by the adhesive of medical sealing of the compo pipe other end：By the other end of the compo pipe of step (3) canned medicine
With adhesive of medical sealing, sterilizing, the embedding thing of medicine is subcutaneously carried up to degradable metal base.
Wherein, the hole diameter described in step (1) is 0.008mm.
The degradable metal base of the present embodiment subcutaneously carries the embedding thing of medicine, has degradability, can be according to alloy material
Proportioning regulation and control degradation time, while after insoluble drug release, can be to avoid the injury that second operation is brought.
The degradable metal base of the present embodiment subcutaneously carries the embedding thing of medicine, has certain mechanical property, can bear surrounding
Tissue extrudes it and indeformable, guarantee drug substance stable release, and medicine can be made to remain relative constant minimum effective in vivo
It is horizontal.
The degradable metal base of the present embodiment subcutaneously carries the embedding thing of medicine, has good biocompatibility, can reduce pair
The injury of body.
The degradable metal base of the present embodiment subcutaneously carries the embedding thing of medicine, suitable for treating mental disease.
Embodiment 5
A kind of degradable metal base of the present embodiment subcutaneously carries the embedding thing of medicine by the medicine of therapeutically effective amount and for accommodating
The metal based alloys pipe composition of medicine；Wherein, the metal based alloys pipe base material is pharmaceutically acceptable metal alloy,
Both ends adhesive of medical sealing, has aperture, metal based alloys pipe outer wrapping dialysis film layer on metal based alloys pipe.The medicine
Thing is contraceptive, and the base material of the compo pipe is the magnesium alloy that pharmaceutically acceptable can degrade in vivo.
The preparation method that a kind of degradable metal base of the present embodiment subcutaneously carries the embedding thing of medicine is to follow the steps below
's：
(1) prepare and carry foraminate compo pipe：Thin-walled thin footpath tubing is made through hot extrusion-drawing in alloy cast ingot, wherein,
Alloy length of tube is 30mm, internal diameter 1mm, pipe thickness 0.1mm.It is uniformly distributed aperture on compo pipe, distance between aperture
Determined by contained medicament categories and dosage.Compo pipe outer wrapping dialysis film layer or antiseepage film layer.
(2) by the adhesive of medical sealing of compo pipe one end：By compo pipe one end medical adhesive obtained by step (1)
Agent sealing；
(3) medicine is loaded：Room temperature, normal pressure, it is sterile under conditions of, contraceptive is loaded into an end seal made from step (2)
Solid compo pipe in；
(4) by the adhesive of medical sealing of the compo pipe other end：By the other end of the compo pipe of step (3) canned medicine
With adhesive of medical sealing, sterilizing, the embedding thing of medicine is subcutaneously carried up to degradable metal base.
Wherein, the hole diameter described in step (1) is 0.005mm.
The degradable metal base of the present embodiment subcutaneously carries the embedding thing of medicine, has degradability, can be according to alloy material
Proportioning regulation and control degradation time, while after insoluble drug release, can be to avoid the injury that second operation is brought.
The degradable metal base of the present embodiment subcutaneously carries the embedding thing of medicine, has certain mechanical property, can bear surrounding
Tissue extrudes it and indeformable, guarantee drug substance stable release, and medicine can be made to remain relative constant minimum effective in vivo
It is horizontal.
The degradable metal base of the present embodiment subcutaneously carries the embedding thing of medicine, has good biocompatibility, can reduce pair
The injury of body.
The degradable metal base of the present embodiment subcutaneously carries the embedding thing of medicine, suitable for treating mental disease.
Embodiment 6
A kind of degradable metal base of the present embodiment subcutaneously carries the embedding thing of medicine by the medicine of therapeutically effective amount and for accommodating
The metal based alloys pipe composition of medicine；Wherein, the metal based alloys pipe base material is pharmaceutically acceptable metal alloy,
Both ends adhesive of medical sealing, has aperture, metal based alloys pipe outer wrapping dialysis film layer on metal based alloys pipe.The medicine
Thing is contraceptive, and the base material of the compo pipe is the magnesium alloy that pharmaceutically acceptable can degrade in vivo.
The preparation method that a kind of degradable metal base of the present embodiment subcutaneously carries the embedding thing of medicine is to follow the steps below
's：
(1) prepare and carry foraminate compo pipe：Thin-walled thin footpath tubing is made through hot extrusion-drawing in alloy cast ingot, wherein,
Alloy length of tube is 100mm, internal diameter 10mm, pipe thickness 1mm.It is uniformly distributed aperture on compo pipe, distance between aperture
Determined by contained medicament categories and dosage.Compo pipe outer wrapping dialysis film layer or antiseepage film layer.
(2) by the adhesive of medical sealing of compo pipe one end：By compo pipe one end medical adhesive obtained by step (1)
Agent sealing；
(3) medicine is loaded：Room temperature, normal pressure, it is sterile under conditions of, contraceptive is loaded into an end seal made from step (2)
Solid compo pipe in；
(4) by the adhesive of medical sealing of the compo pipe other end：By the other end of the compo pipe of step (3) canned medicine
With adhesive of medical sealing, sterilizing, the embedding thing of medicine is subcutaneously carried up to degradable metal base.
Wherein, the hole diameter described in step (1) is 0.01mm.
The degradable metal base of the present embodiment subcutaneously carries the embedding thing of medicine, has degradability, can be according to alloy material
Proportioning regulation and control degradation time, while after insoluble drug release, can be to avoid the injury that second operation is brought.
The degradable metal base of the present embodiment subcutaneously carries the embedding thing of medicine, has certain mechanical property, can bear surrounding
Tissue extrudes it and indeformable, guarantee drug substance stable release, and medicine can be made to remain relative constant minimum effective in vivo
It is horizontal.
The degradable metal base of the present embodiment subcutaneously carries the embedding thing of medicine, has good biocompatibility, can reduce pair
The injury of body.
The degradable metal base of the present embodiment subcutaneously carries the embedding thing of medicine, suitable for treating mental disease.
Embodiment 7
A kind of degradable metal base of the present embodiment subcutaneously carries the embedding thing of medicine by the medicine of therapeutically effective amount and for accommodating
The metal based alloys pipe composition of medicine；Wherein, the metal based alloys pipe base material is pharmaceutically acceptable metal alloy,
Both ends adhesive of medical sealing, has aperture, metal based alloys pipe outer wrapping dialysis film layer on metal based alloys pipe.The medicine
Thing is contraceptive, and the base material of the compo pipe is the magnesium alloy that pharmaceutically acceptable can degrade in vivo.
The preparation method that a kind of degradable metal base of the present embodiment subcutaneously carries the embedding thing of medicine is to follow the steps below
's：
(1) prepare and carry foraminate compo pipe：Thin-walled thin footpath tubing is made through hot extrusion-drawing in alloy cast ingot, wherein,
Alloy length of tube is 80mm, internal diameter 8mm, pipe thickness 0.6mm.It is uniformly distributed aperture on compo pipe, distance between aperture
Determined by contained medicament categories and dosage.Compo pipe outer wrapping dialysis film layer or antiseepage film layer.
(2) by the adhesive of medical sealing of compo pipe one end：By compo pipe one end medical adhesive obtained by step (1)
Agent sealing；
(3) medicine is loaded：Room temperature, normal pressure, it is sterile under conditions of, contraceptive is loaded into an end seal made from step (2)
Solid compo pipe in；
(4) by the adhesive of medical sealing of the compo pipe other end：By the other end of the compo pipe of step (3) canned medicine
With adhesive of medical sealing, sterilizing, the embedding thing of medicine is subcutaneously carried up to degradable metal base.
Wherein, the hole diameter described in step (1) is 0.006mm.
The degradable metal base of the present embodiment subcutaneously carries the embedding thing of medicine, has degradability, can be according to alloy material
Proportioning regulation and control degradation time, while after insoluble drug release, can be to avoid the injury that second operation is brought.
The degradable metal base of the present embodiment subcutaneously carries the embedding thing of medicine, has certain mechanical property, can bear surrounding
Tissue extrudes it and indeformable, guarantee drug substance stable release, and medicine can be made to remain relative constant minimum effective in vivo
It is horizontal.
The degradable metal base of the present embodiment subcutaneously carries the embedding thing of medicine, has good biocompatibility, can reduce pair
The injury of body.
The degradable metal base of the present embodiment subcutaneously carries the embedding thing of medicine, suitable for treating mental disease.
Embodiment 8
A kind of degradable metal base of the present embodiment subcutaneously carries the embedding thing of medicine by the medicine of therapeutically effective amount and for accommodating
The metal based alloys pipe composition of medicine；Wherein, the metal based alloys pipe base material is pharmaceutically acceptable metal alloy,
Both ends adhesive of medical sealing, has aperture, metal based alloys pipe outer wrapping dialysis film layer on metal based alloys pipe.The medicine
Thing is contraceptive, and the base material of the compo pipe is the magnesium alloy that pharmaceutically acceptable can degrade in vivo.
The preparation method that a kind of degradable metal base of the present embodiment subcutaneously carries the embedding thing of medicine is to follow the steps below
's：
(1) prepare and carry foraminate compo pipe：Thin-walled thin footpath tubing is made through hot extrusion-drawing in alloy cast ingot, wherein,
Alloy length of tube is 70mm, internal diameter 4mm, pipe thickness 0.3mm.It is uniformly distributed aperture on compo pipe, distance between aperture
Determined by contained medicament categories and dosage.Compo pipe outer wrapping dialysis film layer or antiseepage film layer.
(2) by the adhesive of medical sealing of compo pipe one end：By compo pipe one end medical adhesive obtained by step (1)
Agent sealing；
(3) medicine is loaded：Room temperature, normal pressure, it is sterile under conditions of, contraceptive is loaded into an end seal made from step (2)
Solid compo pipe in；
(4) by the adhesive of medical sealing of the compo pipe other end：By the other end of the compo pipe of step (3) canned medicine
With adhesive of medical sealing, sterilizing, the embedding thing of medicine is subcutaneously carried up to degradable metal base.
Wherein, the hole diameter described in step (1) is 0.008mm.
The degradable metal base of the present embodiment subcutaneously carries the embedding thing of medicine, has degradability, can be according to alloy material
Proportioning regulation and control degradation time, while after insoluble drug release, can be to avoid the injury that second operation is brought.
The degradable metal base of the present embodiment subcutaneously carries the embedding thing of medicine, has certain mechanical property, can bear surrounding
Tissue extrudes it and indeformable, guarantee drug substance stable release, and medicine can be made to remain relative constant minimum effective in vivo
It is horizontal.
The degradable metal base of the present embodiment subcutaneously carries the embedding thing of medicine, has good biocompatibility, can reduce pair
The injury of body.
The degradable metal base of the present embodiment subcutaneously carries the embedding thing of medicine, suitable for treating mental disease.
Claims (10)
1. a kind of degradable metal base subcutaneously carries the embedding thing of medicine, it is characterised in that it is embedding that the degradable metal base subcutaneously carries medicine
Thing is made of medicine and the metal based alloys pipe for accommodating medicine；Wherein, the metal based alloys pipe both ends are glued with medical
Mixture sealing, compo pipe are equipped with equally distributed aperture, compo pipe outer wrapping dialysis film layer or antiseepage film layer.
2. a kind of degradable metal base according to claim 1 subcutaneously carries the embedding thing of medicine, it is characterised in that the metal
Base alloy pipe material is medical metal alloy.
3. a kind of degradable metal base according to claim 2 subcutaneously carries the embedding thing of medicine, it is characterised in that the metal closes
Gold is magnesium alloy or kirsite.
4. a kind of degradable metal base according to claim 1 subcutaneously carries the embedding thing of medicine, it is characterised in that the compo pipe
Length is 10~100mm, and internal diameter is 1~10mm, and pipe thickness is 0.1mm~1mm.
5. a kind of degradable metal base according to claim 4 subcutaneously carries the embedding thing of medicine, it is characterised in that the compo pipe
Length is 30~100mm, and internal diameter is 2~10mm, and pipe thickness is 0.3mm~1mm.
6. a kind of degradable metal base according to claim 5 subcutaneously carries the embedding thing of medicine, it is characterised in that the compo pipe
Length is 30~80mm, and internal diameter is 2~6mm, and pipe thickness is 0.3mm~5mm.
7. a kind of degradable metal base according to claim 1 subcutaneously carries the embedding thing of medicine, it is characterised in that the medicine is
Hypertension suppresses medicine, diabetes suppress medicine, antipsychotics or contraceptive.
8. a kind of degradable metal base subcutaneously carries the preparation method of the embedding thing of medicine, it is characterised in that it is to follow the steps below
's：
First, prepare and be uniformly distributed foraminate metal based alloys pipe；
2nd, by the adhesive of medical sealing of metal based alloys pipe one end；
3rd, medicine is loaded from the metal based alloys pipe other end；
4th, by the adhesive of medical sealing of the metal based alloys pipe other end；
Wherein, the hole diameter described in step 1 is 0.001~0.1mm.
9. a kind of degradable metal base according to claim 8 subcutaneously carries the preparation method of the embedding thing of medicine, it is characterised in that
Metal based alloys tube preparation method in step 1 is as follows：
Thin-walled thin footpath tubing is made through hot extrusion-drawing in alloy cast ingot, wherein alloy length of tube is 10~100mm, internal diameter 1
~10mm, pipe thickness are 0.1mm~1mm；Aperture, compo pipe outer wrapping dialysis film layer or antiseepage film are uniformly arranged on tubing
Layer.
10. a kind of degradable metal base according to claim 8 subcutaneously carries the preparation method of the embedding thing of medicine, it is characterised in that
The powder charge process of step 3 is as follows：Room temperature, normal pressure, it is sterile under conditions of, by hypertension suppress medicine, diabetes depressant
Thing, antipsychotics or contraceptive are fitted into the metal based alloys pipe of one end sealing made from step 2.
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| CN201711195316.0A CN107970522A (en) | 2017-11-24 | 2017-11-24 | A kind of degradable metal base subcutaneously carries embedding thing of medicine and preparation method thereof |
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| CN201711195316.0A CN107970522A (en) | 2017-11-24 | 2017-11-24 | A kind of degradable metal base subcutaneously carries embedding thing of medicine and preparation method thereof |
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