CN107961291A - 一种用于预防母猪产后瘫痪的中药组合物及其制备方法和应用 - Google Patents
一种用于预防母猪产后瘫痪的中药组合物及其制备方法和应用 Download PDFInfo
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Abstract
本发明公开了一种用于预防母猪产后瘫痪的中药组合物,是由按照重量份计的以下原料制备得到的:当归18‑32份,熟地12‑18份,白芍8‑15份,木香7‑12份,茯苓7‑15份,白术6‑12份,陈皮6‑10份,甘草6‑10份;并提供了其制备方法和应用。本发明的有益效果为:本发明提供的中药组合物,是从中兽医整体观念出发,依据中兽医辩证论治理论,结合母猪产后瘫痪的发病特点,根据中兽医学“致病求其本”的原则,不但补血养血,还健脾助运。气血是互生互根的,补血当先补气,气血的生化又需要靠脾的运化,而且补血之品多粘腻,有碍吸收,所以,健脾益气还能够舒塞,帮助吸收。而且加入木香、陈皮行气,使整个方子补而不腻,补而不滞。
Description
技术领域
本发明涉及兽药保健技术领域,具体涉及一种用于预防母猪产后瘫痪的中药组合物及其制备方法和应用。
背景技术
母猪产后瘫痪又称产后风,是母猪产后体质衰弱而发生的一种急性严重神经性疾病,其特征是知觉丧失、四肢瘫痪。在饲养管理粗放的条件下极易发生,一般认为与血糖和血钙过少有密切关系,以及产后出血、血压降低等原因,致使大脑皮层发生机能性障碍。此外,母猪分娩时由于胎儿过大,胎势及胎位不正或难产时间过长以及强力拉出胎儿,使闭孔神经及臀神经受压迫或挫伤,可引起麻痹;更主要是母猪日粮中精料比例过高,日粮中钙、磷不足,精料中谷类、豆类等比例过大,以及饥饿、营养不良、维生素缺乏等因素引起母猪产后不能站立、知觉减退而引起瘫痪的一种疾病。一般发生在哺乳20d左右,部分发生在产前。此病死亡率虽不高,但常使母猪失去饲养价值,并使仔猪因缺乳影响生长发育,甚至造成死亡,经济损失较大。
目前,对于母猪产后瘫痪的治疗主要是静脉注射10%的葡萄糖酸钙溶液,或者肌肉注射维生素A、D,或者肌肉注射维丁胶性钙,或者在饲料中添加磷酸氢钙或骨粉。这些治疗措施在一定程度上治愈或缓解母猪产后瘫痪。但是由于母猪产后瘫痪造成的采食量下降,奶水不足,严重影响新生仔猪的健康成长和产后的发情。
中兽医认为母猪产后瘫痪属于“血虚生风”病症。“血虚生风”证是指肝血亏虚,虚风内动,以眩晕,肢体震颤、麻木、拘急、瞤动、瘙痒与血虚症状为主要表现。主要是因为母猪在怀孕期间,胎儿与母体争夺气血,加上妊娠期饲喂营养不合理,致使营养摄入不够,气血生成不足,而分娩过程不同程度出血造成血虚。
母猪产后瘫痪后补钙的做法只能解一时燃眉之急,随后出现的奶水不足,质量差,仍是影响仔猪生长的一大障碍。解决母猪产后瘫痪,应从解决怀孕期母猪气血不足的角度入手才是解决根本。通过补气养血,不仅从根源上杜绝产后瘫痪的发生,而且产后初乳以及常乳充足,仔猪健壮,生长快。
发明内容
本发明的目的就是针对上述现有技术中的缺陷,提供了一种科学配比、效果好、无毒副作用的用于预防母猪产后瘫痪的中药组合物及其制备方法和应用。
为了实现上述目的,本发明提供的技术方案为:一种用于预防母猪产后瘫痪的中药组合物,是由按照重量份计的以下原料制备得到的:当归18-32份,熟地12-18份,白芍8-15份,木香7-12份,茯苓7-15份,白术6-12份,陈皮6-10份,甘草6-10份。
进一步的,上述的一种用于预防母猪产后瘫痪的中药组合物,是由按照重量份计的以下原料制备得到的:当归20份,熟地15份,白芍12份,木香10份,茯苓11份,白术11份,陈皮8份,甘草8份。
本发明的第二个目的是提供了上述一种用于预防母猪产后瘫痪的中药组合物的制备方法,是将各中药原料组分按照配比称取后,混合并粉碎至40-200目即可。
本发明的第三个目的是提供了上述一种用于预防母猪产后瘫痪的中药组合物的另一种制备方法,包括以下步骤:
1)取各中药原料组分按照配比混合均匀,加入中药原料总重量3倍的清水清洗并浸泡30分钟后取出,得到清洗浸泡后中药原料;
2)将步骤1)得到的清洗浸泡后中药原料加入中药原料总重量10倍的水煎煮3次,每次1小时,得到中药煎煮提取液;
3)将步骤2)3次煎煮后得到的中药煎煮提取液过滤后合并,浓缩至相对密度为1.13,过滤,再加入双蒸水调节生药含量为1mg/mL,分装,高压灭菌即可。
本发明的第四个目的是提供了上述的制备方法制备得到的中药组合物在制备用于预防母猪产后瘫痪的药物中的应用。
进一步的,上述的应用,以中药组合物制备的预防母猪产后瘫痪的药物,其使用方法为产前20天在母猪的饲料中拌入,每吨饲料加入4kg中药组合物。
本发明的第五个目的是提供了上述的制备方法制备得到的中药组合物在制备用于预防母猪产后瘫痪的药物中的应用。
进一步的,上述的应用,以中药组合物制备的预防母猪产后瘫痪的药物,其使用方法为每头母猪100ml,每天2次,7天为1个疗程,产前用2个疗程即可。
本发明中,当归补血活血,熟地滋阴补血为君药,茯苓白术健脾益气为臣药,白芍敛阴养血,陈皮木香行气健脾为佐药,甘草性平,调和诸药。以上诸药合用,共奏补血活血、健脾益气之功效。方中当归和熟地为补血养血要药,辅以木香、陈皮行气,实现气血双补,同时用茯苓和苍术健脾益气,从根本上提高机体的运化功能,佐以白芍,养血敛阴,巩固当归和熟地的补血养血效果,用甘草所使,调和诸药。组方充分依据中兽医传统理论,立足于母猪产后瘫痪的血虚证本质,组方科学,互相补充,相得益彰。
本发明的有益效果为:
本发明提供的中药组合物,是从中兽医整体观念出发,依据中兽医辩证论治理论,结合母猪产后瘫痪的发病特点,根据中兽医学“致病求其本”的原则,不但补血养血,还健脾助运。气血是互生互根的,补血当先补气,气血的生化又需要靠脾的运化,而且补血之品多粘腻,有碍吸收,所以,健脾益气还能够舒塞,帮助吸收。而且加入木香、陈皮行气,使整个方子补而不腻,补而不滞。
同时,本发明提供的中药组合物产品还具有以下优点:
1、符合农产品质量安全体系建设的原则,符合绿色环保型农业投入品的要求;符合国际医药生产管理规范的要求;符合养羊业发展方向的要求;符合国家兽药开发的产业政策和食品安全的要求,有益于我国养羊业健康快速的发展,对生产绿色、无公害畜产品具有重要意义。
2、符合独立知识产权新兽药和兽用中草药现代化发展的需要。我国自主知识产权的兽用原料药很少,绝大部分西兽药制剂仍有依赖于进口原料药的态势,成为我国兽药更好更快发展的瓶颈。开发拥有独立知识产权的安全型新兽药已是大势所趋。
3、符合国家食品药品安全和兽药GMP规范的要求。在中兽医理论指导下,加强兽用中草药和天然药物的研发,使中兽药生产实现技术现代化、质量标准化和产品规模化,才能充分发挥中草药传统优势,才能促进兽用中草药产业的健康有续发展,最终带动国产兽药的自身发展和走向国际化。
具体实施方式
实施例1:
用于预防母猪产后瘫痪的中药组合物,由以下中药原料制成:当归20公斤,熟地15公斤,白芍12公斤,木香10公斤,茯苓11公斤,白术11公斤,陈皮8公斤,甘草8公斤。
其制备方法,包括以下步骤:取各中药原料粉碎至40-200目,混合均匀,拌料饲喂;
以中药组合物制备的母猪产后瘫痪的药物,其使用方法为产前20天在母猪的饲料中拌入,每吨饲料加入4kg中药。
实施例2:
用于预防母猪产后瘫痪的中药组合物,由以下中药原料制成:党归26公斤,熟地13公斤,白芍13公斤,木香6公斤,茯苓8公斤,白术8公斤,陈皮8公斤,甘草8公斤。
其制备方法,包括以下步骤:取各中药原料粉碎至40-200目,混合均匀,拌料饲喂;
以中药组合物制备的预防母猪产后瘫痪的药物,其使用方法为产前20天在母猪的饲料中拌入,每吨饲料加入4kg中药。
实施例3:
用于预防母猪产后瘫痪的中药组合物,由以下中药原料制成:当归20公斤,熟地15公斤,白芍12公斤,木香10公斤,茯苓11公斤,白术11公斤,陈皮8公斤,甘草8公斤。
其制备方法,包括以下步骤:
1)取各中药原料混合均匀,加入中药原料总重量3倍的清水清洗并浸泡30分钟后取出,得到清洗浸泡后中药原料;
2)将步骤1)得到的清洗浸泡后中药原料加入中药原料总重量10倍的水煎煮3次,每次1小时,得到中药煎煮提取液;
3)将步骤2)3次煎煮后得到的中药煎煮提取液过滤后合并,浓缩至相对密度为1.13左右,过滤,再加入双蒸水调节生药含量为1mg/mL,分装,高压灭菌。
以中药组合物制备的预防母猪产后瘫痪的药物,其使用方法为每头100ml,每天2次,7天为1个疗程,一般产前用2个疗程。
实施例4:
一、临床效果试验:
用按本发明实施例1的技术方案制备的预防母猪产后瘫痪的中药组合物,共预防母猪60头,有效59头,保护率为98.33%;发病1头,无效率1.67%。
用按本发明实施例2的技术方案制备的预防母猪产后瘫痪的中药组合物,共预防母猪90头,有效88头,保护率为97.78%;发病1头,无效率2.22%。
用按本发明实施例3的技术方案制备的预防母猪产后瘫痪的中药组合物,共预防母猪68头,有效67头,保护率为98.53%;发病1头,无效率1.47%。
二、安全性评价:
为了明确本组方的毒副作用,并对其安全性做出准确、客观的评价,为临床用药提供科学依据,确保用药安全,进行了本制剂的毒性试验。
通过对小鼠灌服制剂LD50试验表明,以煎煮后药物浓度1g/mL和耐受的最大给药容积给药,没有小鼠死亡,无法测出灌胃给药方式的LD50,只能表明该制剂口服灌胃的LD50>40000mg/kg体重。通过腹腔注射给药,在药物浓度1g/mL和最大给药容积下,也无小鼠死亡,无法测出腹腔注射给药方式的LD50,故认为腹腔注射的LD50>10000mg/kg体重。根据《兽药试验技术规范汇编》的结果评定标准以及毒理学评价标准,判定本制剂实际无毒。在最大给药量试验中,16h内4次灌胃给药,每次以小鼠灌胃给药的最大给药容积给药,除给药后出现稍有不适、不爱活动、采食量下降等症状外,在常规观察的10d内小白鼠的状况良好,没有出现异常现象,且无一只死亡。
为了掌握因连续使用而产生毒副反应和严重程度以及停药后的发展和恢复情况,为拟定临床安全用药剂量提供参考。按40000mg/kg组、20000mg/kg组、10000mg/kg组和0剂量组口服灌胃给药,连续28d进行了亚急性毒性试验。在试验期内,高剂量体重减轻明显外,其余各试验组小鼠的饮食、行为、粪便均正常,发育良好,无任何中毒症状且血象及血清中CREA、ALT、ALP、AST、TP、ALB的均在正常范围,说明本制剂是安全的。
最后应说明的是:以上所述仅为本发明的优选实施例而已,并不用于限制本发明,尽管参照前述实施例对本发明进行了详细的说明,对于本领域的技术人员来说,其依然可以对前述各实施例所记载的技术方案进行修改,或者对其中部分技术特征进行等同替换。凡在本发明的精神和原则之内,所作的任何修改、等同替换、改进等,均应包含在本发明的保护范围之内。
Claims (8)
1.一种用于预防母猪产后瘫痪的中药组合物,其特征在于,是由按照重量份计的以下原料制备得到的:当归18-32份,熟地12-18份,白芍8-15份,木香7-12份,茯苓7-15份,白术6-12份,陈皮6-10份,甘草6-10份。
2.根据权利要求1所述的一种用于预防母猪产后瘫痪的中药组合物,其特征在于,是由按照重量份计的以下原料制备得到的:当归20份,熟地15份,白芍12份,木香10份,茯苓11份,白术11份,陈皮8份,甘草8份。
3.根据权利要求1或2所述的一种用于预防母猪产后瘫痪的中药组合物的制备方法,其特征在于,是将各中药原料组分按照配比称取后,混合并粉碎至40-200目即可。
4.根据权利要求1或2所述的一种用于预防母猪产后瘫痪的中药组合物的制备方法,其特征在于,包括以下步骤:
1)取各中药原料组分按照配比混合均匀,加入中药原料总重量3倍的清水清洗并浸泡30分钟后取出,得到清洗浸泡后中药原料;
2)将步骤1)得到的清洗浸泡后中药原料加入中药原料总重量10倍的水煎煮3次,每次1小时,得到中药煎煮提取液;
3)将步骤2)3次煎煮后得到的中药煎煮提取液过滤后合并,浓缩至相对密度为1.13,过滤,再加入双蒸水调节生药含量为1mg/mL,分装,高压灭菌即可。
5.根据权利要求3所述的制备方法制备得到的中药组合物在制备用于预防母猪产后瘫痪的药物中的应用。
6.根据权利要求5所述的应用,其特征在于,以中药组合物制备的预防母猪产后瘫痪的药物,其使用方法为产前20天在母猪的饲料中拌入,每吨饲料加入4kg中药组合物。
7.根据权利要求4所述的制备方法制备得到的中药组合物在制备用于预防母猪产后瘫痪的药物中的应用。
8.根据权利要求7所述的应用,其特征在于,以中药组合物制备的预防母猪产后瘫痪的药物,其使用方法为每头母猪100ml,每天2次,7天为1个疗程,产前用2个疗程即可。
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