CN107961114A - A kind of wound dressing and its production method based on solid particle oxygen supply - Google Patents

A kind of wound dressing and its production method based on solid particle oxygen supply Download PDF

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Publication number
CN107961114A
CN107961114A CN201711377548.8A CN201711377548A CN107961114A CN 107961114 A CN107961114 A CN 107961114A CN 201711377548 A CN201711377548 A CN 201711377548A CN 107961114 A CN107961114 A CN 107961114A
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CN
China
Prior art keywords
oxygen
layer
solid particle
wound
oxygen supply
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201711377548.8A
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Chinese (zh)
Inventor
程东
郑岩
程济元
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cheng Jiyuan
Original Assignee
Dalian Maritime University
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Filing date
Publication date
Application filed by Dalian Maritime University filed Critical Dalian Maritime University
Priority to CN201711377548.8A priority Critical patent/CN107961114A/en
Publication of CN107961114A publication Critical patent/CN107961114A/en
Pending legal-status Critical Current

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00Bandages or dressings; Absorbent pads
    • A61F13/02Adhesive plasters or dressings
    • A61F13/0259Adhesive plasters or dressings characterised by the release liner covering the skin adhering layer
    • A61F13/0266Adhesive plasters or dressings characterised by the release liner covering the skin adhering layer especially adapted for wound covering/occlusive dressings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00Bandages or dressings; Absorbent pads
    • A61F13/00051Accessories for dressings
    • A61F13/00063Accessories for dressings comprising medicaments or additives, e.g. odor control, PH control, debriding, antimicrobic
    • A61F13/01029
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00Bandages or dressings; Absorbent pads
    • A61F13/02Adhesive plasters or dressings
    • A61F13/0203Adhesive plasters or dressings having a fluid handling member
    • A61F13/0206Adhesive plasters or dressings having a fluid handling member the fluid handling member being absorbent fibrous layer, e.g. woven or nonwoven absorbent pad, island dressings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00Bandages or dressings; Absorbent pads
    • A61F13/02Adhesive plasters or dressings
    • A61F13/0276Apparatus or processes for manufacturing adhesive dressings or bandages
    • A61F13/0289Apparatus or processes for manufacturing adhesive dressings or bandages manufacturing of adhesive dressings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/18Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42Use of materials characterised by their function or physical properties
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00Bandages or dressings; Absorbent pads
    • A61F2013/00089Wound bandages
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00Bandages or dressings; Absorbent pads
    • A61F2013/00361Plasters
    • A61F2013/00655Plasters adhesive
    • A61F2013/00697Plasters adhesive elastomer-, e.g. rubber- based
    • A61F2013/00702Plasters adhesive elastomer-, e.g. rubber- based silicon-based

Abstract

The invention discloses a kind of wound dressing and its production method based on solid particle oxygen supply, it is characterised in that:From top to bottom successively mainly by waterproof membrane, for oxygen layer, water absorption pad and protective layer form, the material for oxygen layer outer layer for air-and water-permeable, include the solid particle mixture of SODIUM PERCARBONATE, manganese dioxide and hydrogel.Wound of the present invention supplies oxygen dressing, and oxygen-enriched environment can be provided for wound, and accelerating wound healing process, mitigates patient's pain sense, and is conducive to repair scar, makes wound beautiful.

Description

A kind of wound dressing and its production method based on solid particle oxygen supply
Technical field
The present invention relates to a kind of medical sanitary articles for use, are applied more particularly, to a kind of wound based on solid particle oxygen supply Material and its production method.
Background technology
After people's injury, wound care can be carried out using wound dressing.It is well known that oxygen rises in the agglutination of wound Important function:The growth and diffusion of bacterium can be controlled;Be conducive to revascularization;Promote the formation of collagen.Tradition at present Wound dressing can be divided into following three kinds by its material therefor and function:1st, inertia dressing:Generally by cotton, lint and flax Cloth is process, the healing to the surface of a wound without obvious effect, but with protection the surface of a wound, have absorbability, make it is simple and cheap A little;2nd, double acting dressing:Local environment caused by this kind of dressing can utilize it promotes wound healing, has stronger Absorption function.Such as the absorbing film made of polyamino Ethyl formate material, or by gelatin, polysaccharide, more dielectric complex compounds and The netted water imbibition polymer of 3 D stereo of methacrylic resin composition, or by polyurethane and polyoxyethylene second two Alcohol porous foam forms.3rd, biological active dressing:Processed and made through new and high technology method using high molecular material and biomaterial Into associativity dressing, there is double-decker, outer layer application high molecular material, there is provided equivalent to the barrier function of epidermis;It is interior The main material of layer choosing is collagen, chitosan and calcium alginate, has biocompatibility, preferable water imbibition, gas permeability, glutinous Attached property and antibacterial, anastalsis.
Although traditional dressing can protect wound, promoting wound healing in various degree, since wound is in agglutination It is often bad in anaerobic condition, healing effect.
Therefore, it is badly in need of a kind of dressing that can independently supply oxygen at present, oxygen-enriched environment, accelerating wound healing mistake is provided for wound Journey, mitigates patient's pain sense, and is conducive to repair scar, makes wound beautiful.
The content of the invention
It is an object of the invention to overcome drawbacks described above existing in the prior art, there is provided one kind oxygen supply dressing, passes through dressing Oxygen-enriched environment is provided for wound.
To achieve the above object, technical scheme is as follows:
A kind of wound dressing based on solid particle oxygen supply, it is characterised in that supplied successively mainly by waterproof membrane from top to bottom Oxygen layer, water absorption pad and protective layer composition, it is described for the material that oxygen layer outer layer is air-and water-permeable, include SODIUM PERCARBONATE, two for oxygen layer The solid particle mixture of manganese oxide and hydrogel, oxygen is generated by chemically reacting.
Preferably, it is in charge structure for oxygen layer, internal layer is network, and the mesh diameter size of grid is mixed less than particle Thing size.
Preferably, the aperture of diameter 2-5mm is uniformly distributed on water absorption pad.
Preferably, water absorption pad surface scribbles soft silicone.
Preferably, dressing includes at least one charge structure, and multiple packs can be with permutation and combination.
Preferably, network uses polyurethane sponge.
A kind of preparation method for oxygen layer of the wound dressing based on solid particle oxygen supply, includes the following steps:
Preparation for oxygen layer carries out in closed dry environment.
A kind of preparation method of the wound dressing based on solid particle oxygen supply, includes the following steps:
Good seal between the waterproof membrane and protective layer of dressing.
It can be seen from the above technical proposal that the present invention has beneficial effect:(1) occur for oxygen layer endoparticle mixture anti- Oxygen can be provided for wound after answering, be conducive to accelerating wound healing process;Mitigate patient's pain sense;Be conducive to repair scar, Make wound beautiful.(2) dressing outermost layer is waterproof membrane, plays dust-proof, waterproof, anti-gas-leak, antipollution effect.(3) dressing bag At least one charge structure is included, can be with permutation and combination when using multiple packs.The structure on the one hand convenient processing wound, during use It can be sheared according to wound size, during for minor cut or wound, dressing area is small, uses single pack;During for big wound, apply Charge level product is big, may be designed to multiple packs and is arranged in a combination;On the other hand, dressing surface is evenly distributed in beneficial to reagent, with Prevent that reagent is in transport, the packing phenomenon of storage engineering in dressing.(4) water absorption pad can absorb secretion and keep wound surface Totally, it is micro- wet, while allow wound exudate to enter intermediate layer again and participate in reaction so as to generate oxygen, it can be provided for wound oxygen-enriched Environment, water absorption pad are uniformly distributed aperture so that wound part secretion can enter pack, so as to promote to chemically react, part Secretion enters water absorption pad.(5) water absorption pad surface can scribble soft silicone, in direct contact with the skin.(also referred to as silicon coagulates soft silicone Glue) effect be to make dressing adhesion skin, make when opening patient without or mitigate feeling of pain.(6) there is protective film, it is effectively anti- Polluted when only storing, transporting, when use opens, and it is convenient to facilitate.Therefore, the distinguishing feature that the present invention has.
Brief description of the drawings
Fig. 1 is a kind of structure diagram of wound dressing based on solid particle oxygen supply provided by the invention;
Fig. 2 is the top view of oxygen supply layer unit pack of the present invention;
Fig. 3 is a kind of structure of second of embodiment of wound dressing based on solid particle oxygen supply provided by the invention Schematic diagram;
Fig. 4 is the top view of second of embodiment provided by the invention;
Fig. 5 is the bottom view of second of embodiment provided by the invention;
1. waterproof membrane in figure, 2. supply oxygen layer, 3. water absorption pads, 4. outer layers, 5. internal layers, 6. protective layers.
Embodiment
Below in conjunction with the accompanying drawings, the embodiment of the present invention is described in further detail.
It should be noted that in following embodiments, when embodiments of the present invention are described in detail, in order to clear Ground represents the structure of the present invention in order to illustrate, special not draw to the structure in attached drawing according to general proportion, and has carried out part Amplification, deformation and simplified processing, therefore, should avoid in this, as limitation of the invention to understand.
Embodiment 1
As shown in Figs. 1-2, a kind of wound oxygen supply dressing based on solid particle, from top to bottom successively by waterproof membrane 1, oxygen supply Layer 2, water absorption pad 3 and protective layer 6 form.
The waterproof membrane 1 is equipped with medical adhesive, realizes fixed dressing on the skin for viscous, has dust-proof, waterproof, leakproof Gas, antipollution effect.
The solid particle mixture that SODIUM PERCARBONATE, manganese dioxide and hydrogel are included for oxygen layer 2, solid particle mixing Thing generates oxygen by chemically reacting, and can provide high-concentration oxygen for wound, be conducive to accelerating wound healing;Mitigate patient's pain Sense;Be conducive to repair scar, make wound beautiful.The effect of SODIUM PERCARBONATE is to provide oxygen, its dosage determines the oxygen supply of wound Amount.The effect of manganese dioxide is catalyst, its dosage influences the formation speed of oxygen.Manganese dioxide amount is few, and reaction speed is slow.Water The dosage of gel depends on three aspects:1) water absorption:For absorbing the liquid of wound and the liquid of chemical reaction generation, avoid Liquid is in direct contact with the skin.Because the liquid of chemical reaction generation is alkali, effect is irritating to the skin.Therefore its dosage depends on In the amount of wound fluid and the amount of chemical reaction generation water.2) reaction speed:The amount of hydrogel is bigger, reaction speed, that is, oxygen life Into speed it is slower.3) expansion rate after absorbing water.Expansion rate is excessive, is easy to cause extruding wound, or seal failure, chemicals Reveal and release skin.It is in charge structure for oxygen layer 2, the outer layer 4 for oxygen layer 2 is the material of air-and water-permeable, and internal layer 5 is grid knot Structure, network use polyurethane sponge, for fixed solid particle, it is uniformly distributed in pack, and the mesh of grid is straight Footpath size is less than solid mixture particle diameter.
The water absorption pad 3, which has, to be absorbed secretion and keeps wound surface clean, micro- wet, while allows wound exudate again Reaction generation oxygen is participated in into for oxygen layer 2.Aperture is uniformly distributed on water absorption pad 3, diameter 2-5mm, can secrete wound part Thing enters promotes chemical reaction for oxygen layer 2.3 surface of water absorption pad scribbles soft silicone, in direct contact with the skin.Soft silicone ( Claim Silica hydrogel) dressing adhesion skin can be made, patient pain's sense can be mitigated or eliminated when opening.
The protective layer, when can prevent from storing, transport dressing be contaminated, dressing using when open.
The preparation method of the dressing, includes the following steps:Good seal between the waterproof membrane 1 and protective layer 4 of dressing.
For the preparation method of oxygen layer 2, include the following steps:Preparation for oxygen layer 2 carries out in closed dry environment.
Embodiment 2
As shown in Figure 2-5, the present embodiment and the difference of embodiment 1 are, described to include at least one medicine for oxygen layer 2 Pack arrangement, as in Figure 3-5, multiple pack permutation and combination.It can be sheared during use according to wound size;When handling minor cut or wound, Dressing area is small, uses single pack;During for big wound, dressing area is big, may be designed to multiple pack permutation and combination Form, such as need to shear, according to shape of wound and size, need to only shear the dressing of corresponding size, open inner layer protective film 1, and it is solid Skin is scheduled on, notices that edge reserves the waterproof membrane 1 of one fixed width to realize sealing;On the other hand, more than one pack knot is designed Structure is conducive to reagent and is evenly distributed in dressing surface, prevents that reagent is in transport, the packing phenomenon of storage engineering in dressing.The dressing It is easy to use.
The foregoing is only a preferred embodiment of the present invention, but protection scope of the present invention be not limited thereto, Any one skilled in the art the invention discloses technical scope in, technique according to the invention scheme and its Inventive concept is subject to equivalent substitution or change, should be covered by the protection scope of the present invention.

Claims (7)

  1. A kind of 1. wound dressing based on solid particle oxygen supply, it is characterised in that from top to bottom successively mainly by waterproof membrane (1), For oxygen layer (2), water absorption pad (3) and protective layer (6) composition are described for the material that oxygen layer (2) outer layer (4) is air-and water-permeable, oxygen supply Layer (2) includes the solid particle mixture of SODIUM PERCARBONATE, manganese dioxide and hydrogel.
  2. 2. a kind of wound dressing based on solid particle oxygen supply according to claim 1, it is characterised in that described to supply oxygen layer (2) it is in charge structure, internal layer (5) is network, and the mesh diameter size of grid is less than granulate mixture diameter.
  3. A kind of 3. wound dressing based on solid particle oxygen supply according to claim 1, it is characterised in that water absorption pad (3) On be uniformly distributed the aperture of diameter 2-5mm.
  4. A kind of 4. wound dressing based on solid particle oxygen supply according to claim 1, it is characterised in that the water absorption pad (3) surface scribbles soft silicone.
  5. 5. a kind of wound dressing based on solid particle oxygen supply according to claim 2, it is characterised in that dressing is included extremely A few charge structure, multiple packs can be with permutation and combination.
  6. A kind of 6. wound dressing based on solid particle oxygen supply according to claim 2, it is characterised in that the grid knot Structure uses polyurethane sponge.
  7. 7. preparing the method for the confession oxygen layer (2) described in power 1, comprise the following steps:
    1) preparation for oxygen layer (2) carries out in closed dry environment.
CN201711377548.8A 2017-12-19 2017-12-19 A kind of wound dressing and its production method based on solid particle oxygen supply Pending CN107961114A (en)

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Application Number Priority Date Filing Date Title
CN201711377548.8A CN107961114A (en) 2017-12-19 2017-12-19 A kind of wound dressing and its production method based on solid particle oxygen supply

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108670555A (en) * 2018-07-24 2018-10-19 党晓卫 A kind of disposable absorbent oxygen supply surface of a wound application
CN108836633A (en) * 2018-05-03 2018-11-20 郑岩 A kind of structure of composite membrane based on a variety of high molecular materials composition(Thin slice)The wound dressing and its production technology of oxygen supply
CN108969197A (en) * 2018-06-06 2018-12-11 郑岩 A kind of oxygen dressing constituted based on high molecular material for carrier multiple film
CN110051474A (en) * 2019-06-03 2019-07-26 郑岩 A kind of oxygen dressing based on a variety of high molecular material structure of composite membrane
CN110613886A (en) * 2018-06-20 2019-12-27 郑岩 Vagina mould treatment device based on multiple macromolecular material preparation
WO2020227848A1 (en) * 2019-05-10 2020-11-19 咏达生医材料股份有限公司 Method for promoting hair growth and improving gray hair condition, and device and apparatus thereof

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US5792090A (en) * 1995-06-15 1998-08-11 Ladin; Daniel Oxygen generating wound dressing
US20060121101A1 (en) * 2004-12-08 2006-06-08 Ladizinsky Daniel A Method for oxygen treatment of intact skin
US20060142684A1 (en) * 2003-04-11 2006-06-29 Shanbrom Technologies, Llc Oxygen releasing material
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US20090202617A1 (en) * 2008-02-13 2009-08-13 Ward Kevin R Gas based wound and tissue therapeutics
US20120269899A1 (en) * 2004-12-08 2012-10-25 Ladizinsky Daniel A Method For Oxygen Treatment Of Intact Skin
WO2013171467A1 (en) * 2012-05-14 2013-11-21 Emco Packaging Systems Ltd. An oxygen generating and carbon dioxide absorbing wound dressing
CN103637877A (en) * 2013-12-25 2014-03-19 浙江隆泰医疗科技股份有限公司 Novel foam composite wound dressing
CN104117057A (en) * 2014-07-09 2014-10-29 广东省医疗器械研究所 Loaded enzyme hydrogel composition with oxygen releasing function and hydrogel prepared from hydrogel composition
CN206995469U (en) * 2016-10-25 2018-02-13 曹荣华 A kind of structure with sustained-release activity oxygen and oxygen

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2024012A (en) * 1978-04-10 1980-01-09 Johnson & Johnson Oxygen-generating surgical dressing
US5792090A (en) * 1995-06-15 1998-08-11 Ladin; Daniel Oxygen generating wound dressing
US20060142684A1 (en) * 2003-04-11 2006-06-29 Shanbrom Technologies, Llc Oxygen releasing material
CN1838976A (en) * 2003-06-18 2006-09-27 奥西班德科技公司 Method and apparatus for supplying gas to an area
US20060121101A1 (en) * 2004-12-08 2006-06-08 Ladizinsky Daniel A Method for oxygen treatment of intact skin
US20120269899A1 (en) * 2004-12-08 2012-10-25 Ladizinsky Daniel A Method For Oxygen Treatment Of Intact Skin
US20090202617A1 (en) * 2008-02-13 2009-08-13 Ward Kevin R Gas based wound and tissue therapeutics
WO2013171467A1 (en) * 2012-05-14 2013-11-21 Emco Packaging Systems Ltd. An oxygen generating and carbon dioxide absorbing wound dressing
CN103637877A (en) * 2013-12-25 2014-03-19 浙江隆泰医疗科技股份有限公司 Novel foam composite wound dressing
CN104117057A (en) * 2014-07-09 2014-10-29 广东省医疗器械研究所 Loaded enzyme hydrogel composition with oxygen releasing function and hydrogel prepared from hydrogel composition
CN206995469U (en) * 2016-10-25 2018-02-13 曹荣华 A kind of structure with sustained-release activity oxygen and oxygen

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108836633A (en) * 2018-05-03 2018-11-20 郑岩 A kind of structure of composite membrane based on a variety of high molecular materials composition(Thin slice)The wound dressing and its production technology of oxygen supply
CN108969197A (en) * 2018-06-06 2018-12-11 郑岩 A kind of oxygen dressing constituted based on high molecular material for carrier multiple film
CN110613886A (en) * 2018-06-20 2019-12-27 郑岩 Vagina mould treatment device based on multiple macromolecular material preparation
CN108670555A (en) * 2018-07-24 2018-10-19 党晓卫 A kind of disposable absorbent oxygen supply surface of a wound application
WO2020227848A1 (en) * 2019-05-10 2020-11-19 咏达生医材料股份有限公司 Method for promoting hair growth and improving gray hair condition, and device and apparatus thereof
CN110051474A (en) * 2019-06-03 2019-07-26 郑岩 A kind of oxygen dressing based on a variety of high molecular material structure of composite membrane

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Effective date of registration: 20180625

Address after: 116000 2-2-5, Linghai Road, Ganjingzi District, Dalian, Liaoning, China. 96

Applicant after: Cheng Jiyuan

Address before: 116000 Linghai Road, Ganjingzi District, Dalian, Liaoning Province, No. 1

Applicant before: Dalian Maritime University

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Application publication date: 20180427