CN107928681A - 一种基于耳垂血液层的微波能量谱无创血糖浓度检测法 - Google Patents
一种基于耳垂血液层的微波能量谱无创血糖浓度检测法 Download PDFInfo
- Publication number
- CN107928681A CN107928681A CN201711321770.6A CN201711321770A CN107928681A CN 107928681 A CN107928681 A CN 107928681A CN 201711321770 A CN201711321770 A CN 201711321770A CN 107928681 A CN107928681 A CN 107928681A
- Authority
- CN
- China
- Prior art keywords
- blood
- blood sugar
- ear
- sugar concentration
- energy spectrum
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004369 blood Anatomy 0.000 title claims abstract description 71
- 239000008280 blood Substances 0.000 title claims abstract description 68
- 210000000624 ear auricle Anatomy 0.000 title claims abstract description 23
- 238000012360 testing method Methods 0.000 title claims abstract description 13
- 238000001228 spectrum Methods 0.000 title claims abstract description 12
- 239000007788 liquid Substances 0.000 title claims abstract description 7
- 238000010183 spectrum analysis Methods 0.000 claims abstract description 3
- 230000003595 spectral effect Effects 0.000 abstract description 5
- 238000000034 method Methods 0.000 description 13
- 238000001514 detection method Methods 0.000 description 10
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 6
- 239000008103 glucose Substances 0.000 description 6
- 206010012601 diabetes mellitus Diseases 0.000 description 3
- 210000003491 skin Anatomy 0.000 description 3
- 108010015776 Glucose oxidase Proteins 0.000 description 2
- 239000004366 Glucose oxidase Substances 0.000 description 2
- 229940116332 glucose oxidase Drugs 0.000 description 2
- 235000019420 glucose oxidase Nutrition 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 238000013334 tissue model Methods 0.000 description 2
- SPFMQWBKVUQXJV-BTVCFUMJSA-N (2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanal;hydrate Chemical compound O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O SPFMQWBKVUQXJV-BTVCFUMJSA-N 0.000 description 1
- 208000031662 Noncommunicable disease Diseases 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 210000004087 cornea Anatomy 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 230000009429 distress Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000012067 mathematical method Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 210000002200 mouth mucosa Anatomy 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 210000001138 tear Anatomy 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 210000002105 tongue Anatomy 0.000 description 1
- 210000003454 tympanic membrane Anatomy 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Medical Informatics (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Optics & Photonics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Abstract
本发明涉及一种基于耳垂血液层的微波能量谱无创血糖浓度检测法,包括下列步骤:制作耳垂模型;配制不同血糖浓度的测试血液;将两个天线置于耳垂模型的两侧,发射天线发射高频正弦波信号,接收天线接收穿过耳垂模型的高频正弦波信号;改变耳垂模型中血液的血糖浓度,使用不同血糖浓度的血液测试,接收到穿过不同血糖浓度的血液的正弦波;对接收到的信号进行能量谱分析,找出能量谱信息中的最大能量,总结出能量谱最大能量值关于被测血液血糖浓度的变化规律。根据这一规律,测量出待测血液的能量谱幅值,即可计算出被测血液的血糖浓度。
Description
技术领域
本发明属于微波无创检测技术领域,涉及一种血糖浓度检测方法。
背景技术
目前,糖尿病已经成为一种全世界范围内流行的非传染性疾病,空腹检测血糖水平已经成为体检的常规项目,有助于初步筛查糖尿病早期患者。目前临床上使用的血糖检测方法主要为葡萄糖氧化酶(GOD)法,它被称为临床检测上的金标准,检测结果十分准确。除此之外,血糖检测法还包括了有创检测中的光学法,微创检测中的皮下植入法和透皮取样法。这些方法都给患者带来了极大痛苦,特别是对于糖尿病患者而言,每天需要进行数次的血糖检测,一种无创无痛的血糖检测方法亟待开发。目前的无创检测法主要是通过检测身体其他组织(例如皮肤、角膜、口腔粘膜、舌和鼓膜等)或者体液(例如尿液、唾液、汗液、泪液)中的葡萄糖含量,通过数学方法间接计算而得,这些方法准确率低,与临床方法实际测量结果相差较大。
发明内容
本发明提供一种利用高频正弦波无创检测人体血糖浓度的方法。该方法检测的目标组织为耳垂组织,通过比较发射和接收波形的能量谱在特征频率处的幅值,计算耳垂组织血液层的相对介电常数值,通过血糖浓度与相对介电常数的对应关系,间接计算出患者的血糖浓度水平。这样的方法避免了对人体有害的有创检测方法,本发明的技术方案如下:
一种基于耳垂血液层的微波能量谱无创血糖浓度检测法,包括下列步骤:
1)制作耳垂模型;
2)配制不同血糖浓度的测试血液;
3)将两个天线置于耳垂模型的两侧,发射天线发射高频正弦波信号,接收天线接收穿过耳垂模型的高频正弦波信号;
4)改变耳垂模型中血液的血糖浓度,使用不同血糖浓度的血液测试,接收到穿过不同血糖浓度的血液的正弦波;
5)对接收到的信号进行能量谱分析,找出能量谱信息中的最大能量,总结出能量谱最大能量值关于被测血液血糖浓度的变化规律。根据这一规律,测量出待测血液的能量谱幅值,即可计算出被测血液的血糖浓度。
附图说明
图1简化耳垂组织模型及天线结构示意图
图2介电常数在68-70之间变化时,接收波的时域图
图3介电常数在68-70之间变化时,接收波的能量谱
具体实施方式
图1为耳垂组织结构的简单模型,为了简单起见,模型中分成了血液层和皮肤层,来验证该方法的有效性。两个天线分别放置在耳垂组织的两侧,分别用于发射和接收高频正弦波。血液层的浓度范围为0~4000mg/dL,对应不同浓度的血液层电测参数如表1所示。
表1不同血糖浓度的血液层对应电磁参数
具体过程如下:
1.建立耳垂组织模型如图1所示,发射天线和接收天线都位于皮肤层表面。
2.设置发射天线发出的波形为频率为1GHz的单频正弦波,得到接收波形。
3.改变血液层的相对介电常数值,使得相对介电常数在68-70之间变化,代表了血液层血糖浓度值的变化。
4.将五条接收曲线绘制在同一张图像上,如图2所示,当血液的介电常数变化时,接收波在时域上有幅值的变化,这表明,通过血糖浓度不同的血液时,正弦波的能量受到损失。
5.在能量谱图上可以看出,如图3所示,当血液的相对介电常数为70(即血糖浓度为0mg/dL)时,接收波的能量为9.778×106,并以此为基准,介电常数每减小0.5,即血糖浓度每增加1000mg/dL时,接收波能量谱幅值增加(万分之0.920)。
6.设实际测得某一接收波能量谱幅值为x,测出穿过蒸馏水的接收波能量谱幅值为y并以其为基准,则由上述表1可以整理得,被测血液的血糖浓度为:
Claims (1)
1.一种基于耳垂血液层的微波能量谱无创血糖浓度检测法,包括下列步骤:
1)制作耳垂模型;
2)配制不同血糖浓度的测试血液;
3)将两个天线置于耳垂模型的两侧,发射天线发射高频正弦波信号,接收天线接收穿过耳垂模型的高频正弦波信号;
4)改变耳垂模型中血液的血糖浓度,使用不同血糖浓度的血液测试,接收到穿过不同血糖浓度的血液的正弦波;
5)对接收到的信号进行能量谱分析,找出能量谱信息中的最大能量,总结出能量谱最大能量值关于被测血液血糖浓度的变化规律。根据这一规律,测量出待测血液的能量谱幅值,即可计算出被测血液的血糖浓度。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201711321770.6A CN107928681B (zh) | 2017-12-12 | 2017-12-12 | 一种基于耳垂血液层的微波能量谱无创血糖浓度检测法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201711321770.6A CN107928681B (zh) | 2017-12-12 | 2017-12-12 | 一种基于耳垂血液层的微波能量谱无创血糖浓度检测法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN107928681A true CN107928681A (zh) | 2018-04-20 |
CN107928681B CN107928681B (zh) | 2020-07-21 |
Family
ID=61942837
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201711321770.6A Expired - Fee Related CN107928681B (zh) | 2017-12-12 | 2017-12-12 | 一种基于耳垂血液层的微波能量谱无创血糖浓度检测法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN107928681B (zh) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110074790A (zh) * | 2019-06-18 | 2019-08-02 | 天津大学 | 基于耳垂血液层的微波时域信号无创血糖浓度检测方法 |
CN110729050A (zh) * | 2019-09-01 | 2020-01-24 | 天津大学 | 一种用于血糖检测的三维耳垂模型的建立方法 |
Citations (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000059371A1 (en) * | 1999-04-01 | 2000-10-12 | Spectrx, Inc. | Dual function assay device |
US6591121B1 (en) * | 1996-09-10 | 2003-07-08 | Xoetronics Llc | Measurement, data acquisition, and signal processing |
US6704587B1 (en) * | 1999-04-01 | 2004-03-09 | Spectrx, Inc. | Dual function assay device |
US20120310055A1 (en) * | 2010-02-10 | 2012-12-06 | Baylor University | Ultra-wide band non-invasive biological sensor and method |
CN103353460A (zh) * | 2013-06-16 | 2013-10-16 | 沈阳创达技术交易市场有限公司 | 微波波谱血糖检测仪 |
CN104921735A (zh) * | 2015-05-15 | 2015-09-23 | 深圳市一体太糖科技有限公司 | 一种微波无创血糖测量系统 |
US20150377865A1 (en) * | 2014-06-27 | 2015-12-31 | Google Inc. | Method for using nanodiamonds to detect nearby magnetic nanoparticles |
CN205031268U (zh) * | 2015-05-15 | 2016-02-17 | 深圳市一体太糖科技有限公司 | 一种基于微波的血糖测量装置 |
CN106256319A (zh) * | 2016-07-15 | 2016-12-28 | 天津大学 | 一种基于超宽带微波信号时频分析的血糖浓度检测方法 |
CN106419932A (zh) * | 2016-07-15 | 2017-02-22 | 天津大学 | 基于超宽带微波信号时频分析的血糖浓度检测方法 |
CN107356613A (zh) * | 2017-08-28 | 2017-11-17 | 天津大学 | 一种微波谐振腔传感器血糖浓度测量方法 |
-
2017
- 2017-12-12 CN CN201711321770.6A patent/CN107928681B/zh not_active Expired - Fee Related
Patent Citations (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6591121B1 (en) * | 1996-09-10 | 2003-07-08 | Xoetronics Llc | Measurement, data acquisition, and signal processing |
WO2000059371A1 (en) * | 1999-04-01 | 2000-10-12 | Spectrx, Inc. | Dual function assay device |
US6704587B1 (en) * | 1999-04-01 | 2004-03-09 | Spectrx, Inc. | Dual function assay device |
US20120310055A1 (en) * | 2010-02-10 | 2012-12-06 | Baylor University | Ultra-wide band non-invasive biological sensor and method |
CN103353460A (zh) * | 2013-06-16 | 2013-10-16 | 沈阳创达技术交易市场有限公司 | 微波波谱血糖检测仪 |
US20150377865A1 (en) * | 2014-06-27 | 2015-12-31 | Google Inc. | Method for using nanodiamonds to detect nearby magnetic nanoparticles |
CN104921735A (zh) * | 2015-05-15 | 2015-09-23 | 深圳市一体太糖科技有限公司 | 一种微波无创血糖测量系统 |
CN205031268U (zh) * | 2015-05-15 | 2016-02-17 | 深圳市一体太糖科技有限公司 | 一种基于微波的血糖测量装置 |
CN106256319A (zh) * | 2016-07-15 | 2016-12-28 | 天津大学 | 一种基于超宽带微波信号时频分析的血糖浓度检测方法 |
CN106419932A (zh) * | 2016-07-15 | 2017-02-22 | 天津大学 | 基于超宽带微波信号时频分析的血糖浓度检测方法 |
CN107356613A (zh) * | 2017-08-28 | 2017-11-17 | 天津大学 | 一种微波谐振腔传感器血糖浓度测量方法 |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110074790A (zh) * | 2019-06-18 | 2019-08-02 | 天津大学 | 基于耳垂血液层的微波时域信号无创血糖浓度检测方法 |
CN110729050A (zh) * | 2019-09-01 | 2020-01-24 | 天津大学 | 一种用于血糖检测的三维耳垂模型的建立方法 |
Also Published As
Publication number | Publication date |
---|---|
CN107928681B (zh) | 2020-07-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP6990187B2 (ja) | 血液中の標的物質の濃度を測定するための方法および装置 | |
US10478101B1 (en) | Continuous glucose monitoring based on remote sensing of variations of parameters of a SiC implanted antenna | |
KR101687465B1 (ko) | 인간 혈액 내에 글루코오스 농도를 측정하기 위한 방법 | |
US9833178B2 (en) | Method and apparatus for measuring glucose in body fluids using sub-dermal body tissue impedance measurements | |
US9514273B2 (en) | Detection device for detecting a blood picture parameter | |
EP3220824A1 (en) | Server apparatus and wearable device for blood glucose monitoring and associated methods | |
US20130289375A1 (en) | Armband for a Detection Device for the Detection of a Blood Count Parameter | |
WO2006010310A1 (fr) | Appareil et technique de surveillance non invasive de composants sanguins via des spectres d'impedance de forme d'impulsion | |
KR20030031894A (ko) | 혈중 포도당 농도의 측정 방법 | |
US9028408B2 (en) | Detection device for the detection of a blood count parameter | |
CN107997769A (zh) | 一种基于耳垂血液层的微波时延无创血糖浓度检测法 | |
Losoya-Leal et al. | State of the art and new perspectives in non-invasive glucose sensors | |
EP1052929A1 (en) | Method and apparatus for non-invasive determination of glucose in body fluids | |
CN109330592A (zh) | 基于超宽带微波s11参数的血糖浓度检测方法 | |
CN107928681A (zh) | 一种基于耳垂血液层的微波能量谱无创血糖浓度检测法 | |
CN109350076A (zh) | 基于超宽带微波s21参数的血糖浓度检测方法 | |
US20080081965A1 (en) | Foreign body response detection in an implanted device | |
CN108095734A (zh) | 一种基于耳垂血液层的微波频谱无创血糖浓度检测法 | |
Nikawa et al. | Blood-sugar monitoring by reflection of millimeter wave | |
CN107361794A (zh) | 一种基于超声组件与周围神经刺激器检测运动神经反馈的装置及方法 | |
CN106037736B (zh) | 一种男性夜间阴茎勃起测量仪及使用方法 | |
Singh et al. | A Defected Ground Comb Shape Microwave Sensor for Non Invasive Measurement of Blood Glucose | |
Turgul et al. | RF/microwave non-invasive blood glucose monitoring: An overview of the limitations, challenges & state-of-the-art | |
US20210259570A1 (en) | Systems and methods for assessing a physiological property of a biological tissue based on its microwave transmission properties | |
CN109350077A (zh) | 基于超宽带微波s12参数的血糖浓度检测方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20200721 |