CN107918026B - Automatic access arrangement of multichannel reagent card - Google Patents
Automatic access arrangement of multichannel reagent card Download PDFInfo
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- CN107918026B CN107918026B CN201711143782.4A CN201711143782A CN107918026B CN 107918026 B CN107918026 B CN 107918026B CN 201711143782 A CN201711143782 A CN 201711143782A CN 107918026 B CN107918026 B CN 107918026B
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
- G01N2035/00099—Characterised by type of test elements
- G01N2035/00108—Test strips, e.g. paper
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- General Health & Medical Sciences (AREA)
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- Automatic Analysis And Handling Materials Therefor (AREA)
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Abstract
The invention relates to the technical field of medical instruments, and provides an automatic access device capable of realizing multichannel reagent cards, which is mainly used for the inside of an in-vitro diagnostic instrument. The automatic multi-channel reagent card storing and taking device comprises a transverse moving mechanism, a front-back moving mechanism, a transfer plate, an elastic card dragging mechanism and the like. The device is used for controlling the transverse movement and the front-back movement of the elastic card dragging mechanism to take the reagent card from the storage position to the transfer plate and then store the reagent card from the transfer plate into the reaction position, so that the automatic access function of the channel reagent card is realized.
Description
Technical Field
The invention belongs to the technical field of medical appliances, and relates to an automatic multi-channel reagent card storing and taking device for full-automatic in-vitro diagnosis and detection equipment.
Background
The full-automatic in-vitro diagnosis and detection equipment is an instrument capable of realizing quantitative or qualitative analysis of an in-vitro sample of a patient, and in order to realize rapid diagnosis, a reagent card is widely used at present, one or a plurality of miniature test papers are arranged in the reagent card, after a blood sample is added for a period of time, visual or optical accurate detection is carried out, and a qualitative or quantitative result can be obtained according to the change of color or the measured light quantity.
The currently used detection instrument is mainly manually operated, namely, a reagent card is taken, a sample is quantitatively sucked by a liquid shifter and added on the reagent card, the reaction time is waited to be over, the detection instrument is manually inserted into the instrument, and a detection mechanism obtains a detection result. The process is cumbersome to operate and can only be used for a small number of tests.
How to realize the high-speed automation of the use of the reagent card is a main problem that the detection mode of the reagent card can be widely popularized and can realize batch detection.
Disclosure of Invention
The invention aims to solve the technical problem of providing an automatic access device for a multichannel reagent card, which is mainly used for the inside of an in-vitro diagnostic instrument. The high-speed automation of the reagent card is realized, so that the reagent card detection mode can be widely popularized and batch detection can be realized.
The technical scheme provided for solving the technical problems is as follows: the invention provides a multichannel reagent card automatic access device which is characterized by comprising a storage plate 1, a reagent card 2, a transverse moving mechanism 3, a front-back moving mechanism 4, a transfer plate 5 and an elastic card dragging mechanism 6.
The transverse moving mechanism 3 comprises a first guide rail sliding block 31, a first linear guide rail 32, a first screw rod stepping motor 33, a first screw rod nut 34, a first motor seat 35, a bearing seat 36, a transverse moving bottom plate 37, a first nut seat 38 and a first zero sensor 39, wherein the first screw rod stepping motor 33 is fixed on the transverse moving bottom plate 37 through the first motor seat 35, the first linear guide rail 32 is arranged on the transverse moving bottom plate 37, the first guide rail sliding block 31 and the first screw rod nut 34 are fixed on the first nut seat 38, the bearing seat 36 is used for supporting the screw rod end part of the first screw rod stepping motor 33, and the first zero sensor 39 controls the zero position of the transverse moving mechanism 3, so that the transverse moving control of the first screw rod stepping motor 33 on the first nut seat 38 is realized.
The front-back moving mechanism 4 consists of a second linear guide rail 41, a second guide rail sliding block 42, a second screw nut 43, a second screw rod stepping motor 44, a front-back moving bottom plate 45, a second motor seat 46, a second nut seat 47 and a second zero sensor 48, wherein the front-back moving bottom plate 45 is fixed on the first nut seat 38, the second linear guide rail 41 and the second motor seat 46 are arranged on the front-back moving bottom plate 45, the second screw rod stepping motor 44 is arranged on the second motor seat 46, the second guide rail sliding block 42 and the second screw nut 43 are fixed on the second nut seat 47, and the second zero sensor 48 controls the zero position of the front-back moving mechanism 4, so that the transverse movement control of the second screw rod stepping motor 44 on the second nut seat 47 is realized.
The elastic drag-clamping mechanism 6 is composed of a third guide rail slide block 61, a sliding connecting rod 62, a drag-clamping pin seat 63, a drag-clamping pin 64 and a spring 65, wherein the third guide rail slide block 61 is arranged on the second linear guide rail 41, the drag-clamping pin seat 63 is fixed on the third guide rail slide block 61, the sliding connecting rod 62 is fixed on the second nut seat 47 and slides unidirectionally with the drag-clamping pin seat 63, the drag-clamping pin 64 is fixed on the drag-clamping pin seat 63, and the spring 65 is used for dragging-clamping pin seat 63, so that the elastic parallel movement of the drag-clamping pin 64 relative to the second nut seat 47 is realized, the accurate positioning during drag-clamping can be realized, and the mechanical position error is eliminated.
The transfer plate 5 is above the elastic drag-clamping mechanism 6, fixed on the front-back moving bottom plate 45 through four supporting connecting columns 7, drag-clamping pins 64 move back and forth relative to the drag-clamping mechanism, the storage plate 1 is fixed on the transverse moving bottom plate 37 through four storage plate supporting columns 8, a reagent card track is arranged on the transfer plate 5, and 2 or more reagent card tracks are arranged on the storage plate 1; and each reagent card track is on a plane.
The storage plate 1 has three positions, namely a batch storage position 11, a reaction waiting position 12 and a sending-out channel 13. The number of the batch storage bits 11 is one or more, the number of the reaction waiting bits 12 is 2 or more, the temperature and humidity environment is adjustable, and the number of the sending-out channels 13 is 1.
The reagent card 2 is used for carrying dry test paper, and the bottom of the reagent card 2 is provided with a groove for locking and separating the drag pin 64 from the reagent card 2.
Compared with the prior art, the multichannel automatic reagent card access device has the advantages that high-speed automation of reagent card use can be realized, so that the reagent card detection mode can be widely popularized and batch detection can be realized.
Drawings
FIG. 1 is a schematic view of an automated multi-channel reagent card access apparatus.
FIG. 2 is a schematic diagram of the internal structure of the automatic access device for the multi-channel reagent card.
Fig. 3 is a schematic view of the construction of the memory board.
Fig. 4 is a schematic drawing of drag capture and exit of a reagent card.
Reference numerals: 1-a storage plate; 2-reagent card; 3-a lateral movement mechanism; 4-a forward and backward movement mechanism; 5-a transfer plate; 6-an elastic drag-and-clamping mechanism; 7-supporting the connecting column; 8. a storage plate support column; 31-a first rail slide; 32-a first linear guide; 33-a first screw stepping motor; 34-a first lead screw nut; 35-a first motor base; 36-bearing seat; 37-moving the soleplate laterally; 38-a first nut seat; 39—a first null sensor; 41-a second linear guide; 42-a second rail slide; 43-a second lead screw nut; 44-a second screw rod stepper motor; 45-moving the bottom plate back and forth; 46-a second motor base; 47-a second nut seat; 48-a second null sensor; 61-a third rail slide; 62-a sliding link; 63-towing pin base; 64-towing bayonet; 65-springs; 11-storing bits in batches; 12-reaction waiting position; 13-a feed-out channel; 5 a-the towing pin enters a front state; 5 b-the drag pin enters the state from front to back; 5 c-the towing pin enters a state transversely; 5 d-pulling the bayonet to transversely exit the state; 5 e-pulling the bayonet to exit the state back and forth; the 5 f-trailing bayonet is in a post-release condition.
Detailed Description
The invention will be further described with reference to the drawings.
Example 1 structural design of automatic Multi-channel reagent card Access device
The multichannel automatic reagent card storing and taking device realizes the random storing and taking transposition function of the reagent card 2 by the combined action of the transverse moving mechanism 3 and the front-back moving mechanism 4 and the cooperation of the elastic card dragging mechanism 6 and the special designed reagent strip shape.
As shown in fig. 1 and 2, the lateral movement mechanism 3 is composed of a first rail slider 31, a first linear rail 32, a first screw stepping motor 33, a first screw nut 34, a first motor base 35, a bearing base 36, a lateral movement bottom plate 37, a first nut base 38, and a first zero sensor 39. The first screw rod stepping motor 33 is fixed on the transversely moving bottom plate 37 through the first motor seat 35, the first linear guide rail 32 is installed on the transversely moving bottom plate 37, the first guide rail sliding block 31 and the first screw rod nut 34 are fixed on the first nut seat 38, the bearing seat 36 is used for supporting the screw rod end part of the first screw rod stepping motor 33, and the first zero sensor 39 is used for controlling the zero position of the transversely moving mechanism 3. This achieves the control of the lateral movement of the first screw stepping motor 33 to the first nut seat 38.
The back and forth moving mechanism 4 is composed of a second linear guide rail 41, a second guide rail sliding block 42, a second screw nut 43, a second screw stepping motor 44, a back and forth moving bottom plate 45, a second motor seat 46, a second nut seat 47 and a second zero sensor 48. The back and forth moving base 45 is fixed on the first nut seat 38, the second linear guide rail 41 and the second motor seat 46 are installed on the back and forth moving base 45, the second screw rod stepping motor 44 is installed on the second motor seat 46, the second guide rail sliding block 42 and the second screw rod nut 43 are fixed on the second nut seat 47, and the second zero sensor 48 controls the zero position of the back and forth moving mechanism 4. This realizes the control of the lateral movement of the second screw stepping motor 44 to the second nut holder 47.
The elastic drag-clamping mechanism 6 consists of a third guide rail slide block 61, a sliding connecting rod 62, a drag-clamping pin seat 63, a drag-clamping pin 64 and a spring 65. Wherein the third rail slider 61 is mounted on the second linear rail 41, the towing pin seat 63 is fixed on the third rail slider 61, the sliding link 62 is fixed on the second nut seat 47 and slides unidirectionally with the towing pin seat 63, the towing pin 64 is fixed on the towing pin seat 63, and the spring 65 is used for towing the locking pin seat 63. Thus, the elastic parallel movement of the dragging pin 64 relative to the second nut seat 47 is realized, and the accurate positioning during dragging and the elimination of mechanical position errors can be realized.
The transfer plate 5 is fixed on the back and forth moving bottom plate 45 above the elastic drag-clamping mechanism 6 through four supporting connecting columns 7, and the drag-clamping pin 64 moves back and forth relatively to the back and forth moving bottom plate. The storage plate 1 is fixed on the transversely movable bottom plate 37 through four storage plate supporting columns 8, a reagent card track is arranged on the transfer plate 5, a plurality of reagent card tracks are arranged on the storage plate 1, and each track is arranged on a plane.
As shown in fig. 3, the storage board 1 has three positions, a batch storage position 11, a reaction waiting position 12, and a send-out channel 13; typically, there are 1 or more batch storage bits 11 for storing reagent cards 2 of multi-level height; the reaction waiting space 12 has 2 or more reagent cards for storing the added sample; the number of the delivery channels 13 is generally 1 for clamping the reagent to the detection site.
The reagent card 2 is used for carrying dry test paper, and the bottom of the reagent card 2 is provided with a groove shown in fig. 4 for locking and separating the drag pin 64 from the reagent card 2.
Example 2 working principle of automatic Multi-channel reagent card Access device
The whole action flow of the automatic multi-channel reagent card storing and taking device comprises the following steps:
firstly, the transfer plate 5 is in an empty state, the first screw rod stepping motor 33 rotates to drive the first nut seat 38 and the front-back moving mechanism 4 to move transversely, the dragging pin 64 moves to the batch storage position 11, and at the moment, the batch storage position 11 and the reagent clamping track groove of the transfer plate 5 are slightly staggered for a small distance;
5a in fig. 4 is the state before the drag pin 64 enters the reagent card;
in fig. 4, 5b is a state that the drag pin 64 enters the reagent card gap forward, at this time, the second screw rod stepper motor 44 rotates to drive the second nut seat 47 to move forward, the drag pin 64 also moves forward by the same stroke under the action of the spring 65 and the sliding connecting rod 62, when the drag pin 64 enters along the gap and contacts the reagent card end face, the second screw rod stepper motor 44 still continues to rotate, the second nut seat 47 continues to move forward, the spring 65 is compressed, the drag pin 64 stops moving, and the influence of the front-back position error of the reagent card is eliminated.
In fig. 4, 5c is a state that the drag pin 64 transversely enters the reagent card, at this time, the first screw stepping motor 33 rotates to drive the transfer plate 5 to transversely move for a small distance, and stop when corresponding to the track groove of the batch storage position 11, at this time, the drag pin 64 moves into the reagent card, so as to realize locking. The second screw stepping motor 44 rotates to drive the second nut seat 47 to move backwards, and the dragging pin 64 drives the reagent card 2 to be transferred into the track groove of the transfer plate 5 from the track of the batch storage position 11.
It is usual that the reagent card 2 on the transfer plate 5 is transported to the site where the sample is added and after the sample is added, the reagent card 2 is returned to a certain free reaction waiting position 12. At this time, the track groove of the transfer plate 5 is required to be opposite to the track groove of the reaction waiting position 12, the second screw rod stepping motor 44 rotates, and the drag pin 64 drives the reagent card 2 to move from the transfer plate 5 to the track groove of the reaction waiting position 12, and under the action of the spring 65, the reagent card 2 is stored into the innermost part of the track groove of the reaction waiting position 12.
In fig. 4, 5d is a state that the drag latch is laterally withdrawn from the reagent card, at this time, the first screw stepping motor 33 rotates, the drag latch 64 is laterally moved to the notch of the reagent card 2, and the drag latch is unlocked from the reagent card.
In fig. 4, 5e is a state that the drag latch retreats from the reagent card opening, and at this time, the second screw stepping motor 44 rotates, and the drag latch 64 retreats from the reagent card 2, and returns to the lower side of the transfer plate 5.
5f in FIG. 4 is the state after the drag pin leaves the reagent card gap.
In general, the reaction waiting space 12 provides a relatively stable temperature and humidity environment, which is beneficial for the effective combination reaction between the sample and the dry test paper in the reagent card.
If there is a new test requirement, the mechanism will acquire a new reagent card 2 and store it in the idle waiting position 12 after the sample is applied.
The transfer plate 5 remains idle until a reagent card in the reaction waiting space 12 reaches a predetermined time. According to the same steps and actions as the new reagent card taking, the reagent card is taken out from the reaction waiting position 12 onto the transfer plate 5 by the elastic card dragging device under the combined action of the transverse moving mechanism 3 and the front-back moving mechanism 4.
The detection device or other processing device of the reagent card can be connected to the delivery channel 13 on the storage board, and the elastic card dragging mechanism 6 moves the reagent card from the transfer board 5 to the delivery channel 13 under the combined action of the transverse moving mechanism 3 and the front-back moving mechanism 4 according to the same steps and actions as the reagent card is stored in the reaction waiting position 12, so that the whole working process is completed.
The foregoing has shown and described the basic principles and main features of the present invention and the advantages of the present invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, and that the above embodiments and descriptions are merely illustrative of the principles of the present invention, and various changes and modifications may be made without departing from the spirit and scope of the invention, which is defined in the appended claims. The scope of the invention is defined by the appended claims and equivalents thereof.
Claims (4)
1. An automatic access device for a multi-channel reagent card is characterized in that,
the multichannel automatic reagent card storing and taking device comprises a storage plate (1), a reagent card (2), a transverse moving mechanism (3), a front-back moving mechanism (4), a transfer plate (5) and an elastic card dragging mechanism (6); the transverse moving mechanism (3) consists of a first guide rail sliding block (31), a first linear guide rail (32), a first screw rod stepping motor (33), a first screw rod nut (34), a first motor seat (35), a bearing seat (36), a transverse moving bottom plate (37), a first nut seat (38) and a first zero sensor (39), wherein the first screw rod stepping motor (33) is fixed on the transverse moving bottom plate (37) through the first motor seat (35), the first linear guide rail (32) is arranged on the transverse moving bottom plate (37), the first guide rail sliding block (31) and the first screw rod nut (34) are fixed on the first nut seat (38), the bearing seat (36) is used for supporting the screw rod end part of the first screw rod stepping motor (33), and the first zero sensor (39) controls the zero position of the transverse moving mechanism (3), so that the transverse moving control of the first screw rod stepping motor (33) on the first nut seat (38) is realized; the front-back moving mechanism (4) consists of a second linear guide rail (41), a second guide rail sliding block (42), a second screw nut (43), a second screw rod stepping motor (44), a front-back moving bottom plate (45), a second motor seat (46), a second nut seat (47) and a second zero sensor (48), wherein the front-back moving bottom plate (45) is fixed on the first nut seat (38), the second linear guide rail (41) and the second motor seat (46) are arranged on the front-back moving bottom plate (45), the second screw rod stepping motor (44) is arranged on the second motor seat (46), the second guide rail sliding block (42) and the second screw rod nut (43) are fixed on the second nut seat (47), and the second zero sensor (48) controls the zero position of the front-back moving mechanism (4), so that the second screw rod stepping motor (44) transversely moves and controls the second nut seat (47); the elastic drag clamp mechanism (6) consists of a third guide rail sliding block (61), a sliding connecting rod (62), a drag clamp pin seat (63), a drag clamp pin (64) and a spring (65), wherein the third guide rail sliding block (61) is arranged on the second linear guide rail (41), the drag clamp pin seat (63) is fixed on the third guide rail sliding block (61), the sliding connecting rod (62) is fixed on the second nut seat (47) and slides unidirectionally with the drag clamp pin seat (63), the drag clamp pin (64) is fixed on the drag clamp pin seat (63), and the spring (65) is used for connecting the drag clamp pin seat (63), so that the elastic parallel movement of the drag clamp pin (64) relative to the second nut seat (47) can be realized, and the accurate positioning during drag clamp can be realized and the position error on a machine can be eliminated; the transfer plate (5) is above the elastic drag-and-clamp mechanism (6), is fixed on the front-and-back moving bottom plate (45) through four support connecting columns (7), drag-and-clamp pins (64) move back and forth relative to the drag-and-clamp mechanism, the storage plate (1) is fixed on the transverse moving bottom plate (37) through four storage plate support columns (8), the transfer plate (5) is provided with a reagent card track, and the storage plate (1) is provided with 2 or more reagent card tracks;
the storage board (1) is provided with three positions, namely batch storage positions (11), reaction waiting positions (12) and a delivery channel (13);
each reagent card track on the storage plate (1) is on a plane; the number of the batch storage bits (11) is one or more.
2. A multi-channel reagent card automatic access device according to claim 1, wherein,
the number of reaction waiting positions (12) is 2 or more, and the number of discharge channels (13) is 1.
3. A multi-channel reagent card automatic access device according to claim 1, wherein,
the bottom of the reagent card (2) is provided with a groove.
4. A multi-channel reagent card automatic access device according to claim 1, wherein,
the temperature and humidity environment of the reaction waiting position (12) is adjustable.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201711143782.4A CN107918026B (en) | 2017-11-17 | 2017-11-17 | Automatic access arrangement of multichannel reagent card |
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| CN201711143782.4A CN107918026B (en) | 2017-11-17 | 2017-11-17 | Automatic access arrangement of multichannel reagent card |
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| CN107918026A CN107918026A (en) | 2018-04-17 |
| CN107918026B true CN107918026B (en) | 2023-04-28 |
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| CN111413510B (en) * | 2019-01-08 | 2024-03-19 | 深圳迎凯生物科技有限公司 | Device control method, device, detection device and storage medium |
| CN110320377A (en) * | 2019-05-09 | 2019-10-11 | 基蛋生物科技股份有限公司 | Reagent card accommodation apparatus |
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