CN107913275A - A kind of store method of folic acid - Google Patents
A kind of store method of folic acid Download PDFInfo
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- CN107913275A CN107913275A CN201711075238.0A CN201711075238A CN107913275A CN 107913275 A CN107913275 A CN 107913275A CN 201711075238 A CN201711075238 A CN 201711075238A CN 107913275 A CN107913275 A CN 107913275A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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Abstract
The invention belongs to medical configuration product field, and in particular to a kind of store method of folic acid, isolates natural folic acid from food；Starch is added into folic acid, and the two is uniformly mixed and obtains mixture A；Mangosteen extract is added dropwise in the mixture A obtained in one step up, and mangosteen extract is uniformly mixed with mixture A, obtains mixture B；Squeeze the juice after tomato and carrot are mixed and add lotus root starch and stir evenly；Material obtained in the previous step is uniformly mixed with mixture B, and is dried in vacuo and obtains mixing C；Honey is uniformly mixed with flour, mixture D is obtained, mixture C is placed in mixture D, and is uniformly mixed mixture C with mixture D by the way of vibration, is dried in vacuo, that is, obtains the folic acid of complete seal.It realizes the sealing and preservation to folic acid by using the mode of multilayer antioxidant material cladding.
Description
Technical field
The invention belongs to medical configuration product field, and in particular to a kind of store method of folic acid.
Background technology
One of folic acid (folic acid) vitamin B complex, equivalent to pteroylglutamic acid (pteroylglutamic
Acid, PGA), it is Michele (H.K.Mitchell, 1941) extraction purification from the leaf of spinach, so it is named as folic acid.There is rush
The effect of juvenile cell maturation into marrow, the mankind can cause macrocytic anemia and leukopenia as lacked folic acid,
It is even more important to pregnant woman.
Main function is：
1) coenzyme as one carbon unit transfer enzyme system in internal biochemical reaction, plays a part of one carbon unit carrier.
2) synthesis of purine and thymidine, further synthetic DNA and RNA are participated in.
3) amino acid metabolism is participated in, in glycine and serine, histidine and glutamic acid, homocysteine and methionine
Between mutually convert during serve as the carrier of one carbon unit.
4) synthesis of hemoglobin and methyl compound such as adrenaline, choline, creatine etc. is participated in.
Food containing folic acid is very much, but since natural folic acid is extremely unstable, is easily influenced by sunlight, heating and oxygen occurs
Change, so folic acid that human body can really be obtained from food and few.Folic acid biological availability is relatively low, 45% or so.Synthesis
Folic acid can keep stable within several months or several years, easily absorb and human body availability be high, be about higher by one times of left side of natural product
The right side, but the natural folic acid that green vegetable etc. contains is absorbed in the enteron aisle of people, and it is absorbed in liver to synthesize folic acid.
The amount that liver absorbs synthesis folic acid is limited, and unabsorbed excessive synthesis folic acid can enter blood, it is possible to leukemogenesis, pass
Save the diseases such as inflammation；Meanwhile the use of synthesis folic acid is more to aggravate bearing for liver for the weaker pregnant woman of some liver functions
Load.
Therefore, analyzed from health perspectives, the folic acid proposed in edible natural food can more utilize the absorption of pregnant woman, and protect
Demonstrate,prove the health of pregnant woman.And how effectively to preserve the folic acid proposed from natural food then becomes a more severe proposition, and
There is not correlative study at present on how to effectively preserve the folic acid extracted in natural food.
The content of the invention
The present invention provides a kind of store method of folic acid, it is realized pair by using the mode that multilayer antioxidant material coats
The sealing and preservation of folic acid.
To realize above-mentioned technical purpose, it is a kind of store method of folic acid that the present invention, which takes concrete technical scheme, including such as
Lower step：
Step 1: natural folic acid is isolated from food；
Step 2: adding starch into folic acid, and the two is uniformly mixed and obtains mixture A, while control starch and leaf
The volume ratio of acid is 1：(1‐4)；
Step 3: mangosteen extract is added dropwise in the mixture A obtained into step 2, mangosteen extract and mixture are controlled
The mass ratio of A is 1：(1-10), and mangosteen extract is uniformly mixed with mixture A, obtain mixture B；
Step 4: squeezing the juice to obtain mixed juice after tomato and carrot are mixed, lotus root starch is added into mixed juice and is stirred equal
It is even, the volume ratio 1 of mixed juice and lotus root starch:(1‐2)；Wherein, the mass ratio of tomato and carrot is (1:9)：(3‐10)；
Step 5: the material that step 4 is obtained is uniformly mixed with mixture B under vibrating conditions, vibration frequency and amplitude
Setting can guarantee that mixed material glomeration, and be dried in vacuo and obtain mixing C；The material that step 4 obtains and mixture B
Volume ratio be 1：(1‐5)；
Step 6: honey is uniformly mixed with flour, the mass ratio of honey and flour is 1：(2-5), obtains mixture D,
Mixture C is placed in mixture D, and is uniformly mixed mixture C with mixture D by the way of vibration, mixture C is with mixing
The volume ratio of compound D is (3-6)：1；
Step 7: the material obtained using vacuum drying mode drying steps six, that is, obtain the folic acid of complete seal.
As the improved technical solution of the present invention, the water content of starch is 10-30% in step 2.
As the improved technical solution of the present invention, step 3 is further included mixture B kneading balling-up, a diameter of 1- of ball
3mm。
It is to mix folic acid and starch by the way of stirring as the improved technical solution of the present invention, in step 2.
As the improved technical solution of the present invention, starch is starch from sweet potato, cornstarch or lotus root starch.
As the improved technical solution of the present invention, being further included in step 2 will at -5-5 DEG C using vacuum drying mode
Mixture A is dried.
As the improved technical solution of the present invention, vacuum drying temperature is -5-10 DEG C in step 5.
As the improved technical solution of the present invention, vacuum drying temperature is -5-20 DEG C in step 7.
As the improved technical solution of the present invention, screening is further included, the folic acid of complete seal is divided by particle size
Level.
Beneficial effect
By the way that folic acid is mixed with starch, folic acid can be locally adsorbed in the micropore of starch the present invention by starch；Meanwhile form sediment
Powder can also absorb the mangosteen extract with high antioxidant, and here, mangosteen extract can effectively avoid the oxidation of folic acid, and form sediment
Powder then plays a cushioning effect, avoids mangosteen extract from directly acting on folic acid, effectively avoids folic acid in extraneous effect
It is lower rotten；Lotus root starch will be added in the mixed juice of tomato and carrot again, the moisture that lotus root starch can be absorbed in mixed juice forms lotus root starch and glues
Liquid, after being mixed with folic acid, starch and mangosteen extract, lotus root starch mucus can be coated on the outer surface of starch, it is effectively realized
Antioxidant in antioxidant in tomato and carrot juice is coated on outside starch, and then realizes and is formed to folic acid
First layer protective film, simultaneously because the characteristic of lotus root starch mucus causes first layer protective film to have certain leakproofness, even in rear
Continuous step 5 dehydration and drying, due to containing certain fiber in carrot juice and tomato juice, these fibers can also cause first layer to protect
Cuticula has certain leakproofness；And honey then forms the second layer protective film of folic acid with flour, even if dehydration and drying, due to bee
The viscosity and the water imbibition of flour of honey so that after dehydration, it is closed that honey is more so that second layer protective film has with flour
Property (airtight)；The effect of honey at the same time also make it that can be good at absorption between first layer protective film and second layer protective film exists
Together, even if follow-up vacuum drying, part honey crystallization can be also permeated in first layer protective film, and the gap of embedded fiber net
In；And the dry tack free that flour is then the folic acid that complete seal is effectively ensured is not glued.
To sum up, the application by antioxidant and the component containing polyphenoils formed protective film jointly realize pair
The folic acid naturally extracted is sealed, and has not only reduced or avoided contact of the folic acid with air, but also effectively suppresses the oxidation of folic acid.Together
When, each component that the application uses is beneficial to health, will not produce any side effect to pregnant woman.
Embodiment
To make the purpose of the embodiment of the present application and technical solution clearer, below in conjunction with the embodiment of the present application to this Shen
Technical solution please is clearly and completely described.Obviously, described embodiment is the part of the embodiment of the application, and
The embodiment being not all of.Based on described embodiments herein, those of ordinary skill in the art are without creative labor
All other embodiments obtained on the premise of dynamic, shall fall in the protection scope of this application.
Embodiment 1
A kind of store method of folic acid, includes the following steps：
Step 1: natural folic acid is isolated from food；
Step 2: adding starch into folic acid, and the two stirring or vibration are uniformly mixed and obtain mixture A, at the same time
It is 1 to control the volume ratio of starch and folic acid：4；
Step 3: mangosteen extract is added dropwise in the mixture A obtained into step 2, mangosteen extract and mixture are controlled
The mass ratio of A is 1：10, and mangosteen extract is uniformly mixed with mixture A, obtain mixture B；
Step 4: squeezing the juice to obtain mixed juice after tomato and carrot are mixed, lotus root starch is added into mixed juice and is stirred equal
It is even, the volume ratio 1 of mixed juice and lotus root starch:2；Wherein, the mass ratio of tomato and carrot is 9：10；
Step 5: the material that step 4 is obtained is uniformly mixed with mixture B under vibrating conditions, vibration frequency and amplitude
Setting can guarantee that mixed material glomeration, and vacuum drying obtains mixing C at -5 DEG C；Material that step 4 obtains with
The volume ratio of mixture B is 1：5；
Step 6: honey is uniformly mixed with flour, the mass ratio of honey and flour is 1：5, mixture D is obtained, will be mixed
Compound C is placed in mixture D, and is uniformly mixed mixture C with mixture D by the way of vibration, mixture C and mixture
The volume ratio of D is 6：1；
Step 7: using the vacuum drying mode material that drying steps six obtain at -5 DEG C, that is, obtain complete seal
Folic acid.
Here, starch is starch from sweet potato, cornstarch or lotus root starch.
Comparative example 1
Difference lies in add flour into folic acid with embodiment 1 in step 2.
Comparative example 2
Difference lies in Step 6: mixture C is placed in water-starch, and will be mixed by the way of vibration with embodiment 1
Compound C is uniformly mixed with water-starch；The water content of water-starch is 20%-30%.
Comparative example 3
Difference lies in press any matter by natural folic acid and hydroxycinnamic acid or hydroxy cinnamic acid derivative with embodiment 1
Amount is coated than being uniformly mixed, and using starch, obtains the folic acid of complete seal.
Comparative example 4
Difference lies in include the following steps with embodiment 1：
Step 1: natural folic acid is isolated from food；
Step 2: adding starch into folic acid, and the two stirring or vibration are uniformly mixed and obtain mixture A, at the same time
It is 1 to control the volume ratio of starch and folic acid：4；
Step 3: squeezing the juice to obtain mixed juice after tomato and carrot are mixed, lotus root starch is added into mixed juice and is stirred equal
It is even, the volume ratio 1 of mixed juice and lotus root starch:2；Wherein, the mass ratio of tomato and carrot is 9：10；
Step 4: the material that step 3 is obtained is uniformly mixed with mixture A under vibrating conditions, vibration frequency and amplitude
Setting can guarantee that mixed material glomeration, and vacuum drying obtains mixing C at -5 DEG C；Material that step 4 obtains with
The volume ratio of mixture A is 1：5；
Step 5: honey is uniformly mixed with flour, the mass ratio of honey and flour is 1：5, mixture D is obtained, will be mixed
Compound C is placed in mixture D, and is uniformly mixed mixture C with mixture D by the way of vibration, mixture C and mixture
The volume ratio of D is 6：1；
Step 6: using the vacuum drying mode material that drying steps six obtain at -5 DEG C, that is, obtain complete seal
Folic acid.
Comparative example 5
A kind of store method of folic acid, includes the following steps：
Step 1: natural folic acid is isolated from food；
Step 2: adding starch into folic acid, and the two stirring or vibration are uniformly mixed and obtain mixture A, at the same time
It is 1 to control the volume ratio of starch and folic acid：4；
Step 3: mangosteen extract is added dropwise in the mixture A obtained into step 2, mangosteen extract and mixture are controlled
The mass ratio of A is 1：10, and mangosteen extract is uniformly mixed with mixture A, obtain mixture B；
Step 6: honey is uniformly mixed with flour, the mass ratio of honey and flour is 1：5, mixture D is obtained, will be mixed
Compound B is placed in mixture D, and is uniformly mixed mixture B with mixture D by the way of vibration, mixture B and mixture
The volume ratio of D is 6：1；
Step 7: carrying the material that drying steps six obtain at -5 DEG C using vacuum drying mode, that is, obtain complete seal
Folic acid.
Embodiment 2
Difference lies in the water content of starch is 10-30% in step 2 with embodiment 1.
Embodiment 3
A kind of store method of folic acid, includes the following steps：
Step 1: natural folic acid is isolated from food；
Step 2: adding starch into folic acid, and the two is uniformly mixed and obtains mixture A, while control starch and leaf
The volume ratio of acid is 1：1；
Step 3: mangosteen extract is added dropwise in the mixture A obtained into step 2, mangosteen extract and mixture are controlled
The mass ratio of A is 1：1, and mangosteen extract is uniformly mixed with mixture A, obtain mixture B；Further include and rub mixture B
Balling-up is pinched, a diameter of 1mm of ball, is also chosen as 3mm, 2mm etc., preferably in 1-3mm；
Step 4: squeezing the juice to obtain mixed juice after tomato and carrot are mixed, lotus root starch is added into mixed juice and is stirred equal
It is even, the volume ratio 1 of mixed juice and lotus root starch:1；Wherein, the mass ratio of tomato and carrot is 1：10；
Step 5: the material that step 4 is obtained is uniformly mixed with mixture B under vibrating conditions, vibration frequency and amplitude
Setting can guarantee that mixed material glomeration, and vacuum drying obtains mixing C at 10 DEG C；Material that step 4 obtains with
The volume ratio of mixture B is 1：1；
Step 6: honey is uniformly mixed with flour, the mass ratio of honey and flour is 1：2, mixture D is obtained, will be mixed
Compound C is placed in mixture D, and is uniformly mixed mixture C with mixture D by the way of vibration, mixture C and mixture
The volume ratio of D is 3：1；
Step 7: using the vacuum drying mode material that drying steps six obtain at 20 DEG C, that is, obtain complete seal
Folic acid.
Embodiment 4
A kind of store method of folic acid, includes the following steps：
Step 1: natural folic acid is isolated from food；
Step 2: adding starch into folic acid, and the two is uniformly mixed and obtains mixture A, while control starch and leaf
The volume ratio of acid is 1：2；Further include and dried mixture A at -5 DEG C using vacuum drying mode；
Step 3: mangosteen extract is added dropwise in the mixture A obtained into step 2, mangosteen extract and mixture are controlled
The mass ratio of A is 1：4, and mangosteen extract is uniformly mixed with mixture A, obtain mixture B；
Step 4: squeezing the juice to obtain mixed juice after tomato and carrot are mixed, lotus root starch is added into mixed juice and is stirred equal
It is even, the volume ratio 1 of mixed juice and lotus root starch:1.5；Wherein, the mass ratio of tomato and carrot is 3：1；
Step 5: the material that step 4 is obtained is uniformly mixed with mixture B under vibrating conditions, vibration frequency and amplitude
Setting can guarantee that mixed material glomeration, and vacuum drying obtains mixing C at 0 DEG C；Material that step 4 obtains with
The volume ratio of mixture B is 1：2；
Step 6: honey is uniformly mixed with flour, the mass ratio of honey and flour is 1：4, mixture D is obtained, will be mixed
Compound C is placed in mixture D, and is uniformly mixed mixture C with mixture D by the way of vibration, mixture C and mixture
The volume ratio of D is 5：1；
Step 7: using the vacuum drying mode material that drying steps six obtain at 10 DEG C, that is, obtain complete seal
Folic acid.
Comparative example 6
Difference lies in be to be dried mixture A at 20 DEG C using vacuum drying mode in step 4 with embodiment 4.
Embodiment 5
A kind of store method of folic acid, includes the following steps：
Step 1: natural folic acid is isolated from food；
Step 2: adding starch into folic acid, and the two stirring or vibration are uniformly mixed and obtain mixture A, at the same time
It is 1 to control the volume ratio of starch and folic acid：3；Further include and at 5 DEG C dried mixture A using vacuum drying mode；
Step 3: mangosteen extract is added dropwise in the mixture A obtained into step 2, mangosteen extract and mixture are controlled
The mass ratio of A is 1：6, and mangosteen extract is uniformly mixed with mixture A, obtain mixture B；
Step 4: squeezing the juice to obtain mixed juice after tomato and carrot are mixed, lotus root starch is added into mixed juice and is stirred equal
It is even, the volume ratio 1 of mixed juice and lotus root starch:1.2 wherein, and the mass ratio of tomato and carrot is 1：3；
Step 5: the material that step 4 is obtained is uniformly mixed with mixture B under vibrating conditions, vibration frequency and amplitude
Setting can guarantee that mixed material glomeration, and vacuum drying obtains mixing C at 9 DEG C；The material that step 4 obtains is with mixing
The volume ratio of compound B is 1：3；
Step 6: honey is uniformly mixed with flour, the mass ratio of honey and flour is 1：4, mixture D is obtained, will be mixed
Compound C is placed in mixture D, and is uniformly mixed mixture C with mixture D by the way of vibration, mixture C and mixture
The volume ratio of D is 4：1；
Step 7: using the vacuum drying mode material that drying steps six obtain at 8 DEG C, that is, obtain complete seal
Folic acid.
Here, starch is starch from sweet potato, cornstarch or lotus root starch.
Comparative example 7
Difference lies in vacuum drying obtains mixing C. at tangible 20 DEG C in step 5 with embodiment 5
Embodiment 6
A kind of store method of folic acid, includes the following steps：
Step 1: natural folic acid is isolated from food；
Step 2: adding starch into folic acid, and the two stirring or vibration are uniformly mixed and obtain mixture A, at the same time
It is 1 to control the volume ratio of starch and folic acid：2；Further include and dried mixture A at 0 DEG C using vacuum drying mode；
Step 3: mangosteen extract is added dropwise in the mixture A obtained into step 2, mangosteen extract and mixture are controlled
The mass ratio of A is 1：3, and mangosteen extract is uniformly mixed with mixture A, obtain mixture B；
Step 4: squeezing the juice to obtain mixed juice after tomato and carrot are mixed, lotus root starch is added into mixed juice and is stirred equal
It is even, the volume ratio 1 of mixed juice and lotus root starch:1.1；Wherein, the mass ratio of tomato and carrot is 1：1；
Step 5: the material that step 4 is obtained is uniformly mixed with mixture B under vibrating conditions, vibration frequency and amplitude
Setting can guarantee that mixed material glomeration, and vacuum drying obtains mixing C at 6 DEG C；The material that step 4 obtains is with mixing
The volume ratio of compound B is 1：5；
Step 6: honey is uniformly mixed with flour, the mass ratio of honey and flour is 1：5, mixture D is obtained, will be mixed
Compound C is placed in mixture D, and is uniformly mixed mixture C with mixture D by the way of vibration, mixture C and mixture
The volume ratio of D is 6：1；
Step 7: using the material that drying steps six obtain at 6 DEG C is dried in vacuo, that is, obtain the folic acid of complete seal.
Here, starch is starch from sweet potato, cornstarch or lotus root starch.
Comparative example 8
Difference lies in using the vacuum drying material that drying steps six obtain at 30 DEG C in step 7 with embodiment 7.
As the improved technical solution of the present invention, screening is further included, the folic acid of complete seal is divided by particle size
Level.
Implementation result
Under ventilated environment, by the folic acid of the complete seal prepared in all embodiments and comparative example, different purples are placed in
Placed 60 days in the illumination of outer intensity, the environment of different temperatures, before comparing 60 days with 60 days after folic acid oxidization condition.
The decomposition situation of measured folic acid is as shown in table 1 below：
The decomposition situation of the folic acid under different UV intensities and different temperatures of table 1
It is obvious to a person skilled in the art that the application is not limited to the details of above-mentioned one exemplary embodiment, Er Qie
In the case of without departing substantially from spirit herein or essential characteristic, the application can be realized in other specific forms.Therefore, no matter
From the point of view of which point, the present embodiments are to be considered as illustrative and not restrictive, and scope of the present application is by appended power
Profit requires rather than described above limits, it is intended that all in the implication and scope of the equivalency of claim by falling
Change is included in the application.
Moreover, it will be appreciated that although the present specification is described in terms of embodiments, not each embodiment is only wrapped
Containing an independent technical solution, this narrating mode of specification is only that those skilled in the art should for clarity
Using specification as an entirety, the technical solutions in the various embodiments may also be suitably combined, forms those skilled in the art
It is appreciated that other embodiment.
Claims (9)
1. a kind of store method of folic acid, it is characterised in that include the following steps：
Step 1: natural folic acid is isolated from food；
Step 2: add starch into folic acid, and the two is uniformly mixed and obtains mixture A, while control starch and folic acid
Volume ratio is 1：(1‐4)；
Step 3: mangosteen extract is added dropwise in the mixture A obtained into step 2, control mangosteen extract is with mixture A's
Mass ratio is 1：(1-10), and mangosteen extract is uniformly mixed with mixture A, obtain mixture B；
Step 4: squeezing the juice to obtain mixed juice after tomato and carrot are mixed, lotus root starch is added into mixed juice and is stirred evenly, is mixed
Close the volume ratio 1 of juice and lotus root starch:(1‐2)；Wherein, the mass ratio of tomato and carrot is (1:9)：(3‐10)；
Step 5: the material that step 4 is obtained is uniformly mixed with mixture B under vibrating conditions, vibration frequency and amplitude are set
Put and can guarantee that mixed material glomeration, and be dried in vacuo and obtain mixing C；The body of the material that step 4 obtains and mixture B
Product is than being 1：(1‐5)；
Step 6: honey is uniformly mixed with flour, the mass ratio of honey and flour is 1：(2-5), obtains mixture D, will be mixed
Compound C is placed in mixture D, and is uniformly mixed mixture C with mixture D by the way of vibration, mixture C and mixture
The volume ratio of D is (3-6)：1；
Step 7: the material obtained using vacuum drying mode drying steps six, that is, obtain the folic acid of complete seal.
2. the store method of a kind of folic acid according to claim 1, it is characterised in that the water content of starch is in step 2
10-30%.
3. the store method of a kind of folic acid according to claim 1, it is characterised in that step 3 is further included mixture B
Kneading balling-up, a diameter of 1-3mm of ball.
4. the store method of a kind of folic acid according to claim 1, it is characterised in that be the side using stirring in step 2
Formula mixes folic acid and starch.
5. the store method of a kind of folic acid according to claim 1, it is characterised in that starch is starch from sweet potato, corn forms sediment
Powder or lotus root starch.
6. the store method of a kind of folic acid according to claim 1, it is characterised in that further included in step 2 using vacuum
Dry mode dries mixture A at -5-5 DEG C.
A kind of 7. store method of folic acid according to claim 1, it is characterised in that vacuum drying temperature in step 5
For -5-10 DEG C.
A kind of 8. store method of folic acid according to claim 1, it is characterised in that vacuum drying temperature in step 7
For -5-20 DEG C.
9. the store method of a kind of folic acid according to claim 1, it is characterised in that screening is further included, by complete seal
Folic acid be classified by particle size.
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| CN201711075238.0A CN107913275A (en) | 2017-11-06 | 2017-11-06 | A kind of store method of folic acid |
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| CN201711075238.0A CN107913275A (en) | 2017-11-06 | 2017-11-06 | A kind of store method of folic acid |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109307720A (en) * | 2018-10-19 | 2019-02-05 | 深圳天辰医疗科技有限公司 | A kind of composition and compound calibration object and its application |
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| CN1242168A (en) * | 1999-06-21 | 2000-01-26 | 孙景文 | Stable type folic acid nutritive product, and prepn. method therefor |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109307720A (en) * | 2018-10-19 | 2019-02-05 | 深圳天辰医疗科技有限公司 | A kind of composition and compound calibration object and its application |
| CN109307720B (en) * | 2018-10-19 | 2021-08-10 | 深圳天辰医疗科技有限公司 | Composition, composite calibrator and application of composite calibrator |
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Application publication date: 20180417 |