CN107898970A - A kind of Chinese medicine composition for treating intractable hiccup and preparation method thereof - Google Patents
A kind of Chinese medicine composition for treating intractable hiccup and preparation method thereof Download PDFInfo
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- CN107898970A CN107898970A CN201711244035.XA CN201711244035A CN107898970A CN 107898970 A CN107898970 A CN 107898970A CN 201711244035 A CN201711244035 A CN 201711244035A CN 107898970 A CN107898970 A CN 107898970A
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Abstract
The invention discloses a kind of Chinese medicine composition for treating intractable hiccup and preparation method thereof, it is characterised in that the Chinese medicine composition is made of the raw material of following parts by weight：7 15 parts of Angelica sinensis, 9 15 parts of stir-baked RADIX PAEONIAE ALBA, 5 10 parts of radix bupleuri, 8 15 parts of Poria cocos, 10 15 parts of ginseng, 10 15 parts of rhizoma atractylodis macrocephalae, 6 10 parts of rhizoma cyperi, 59 parts of Radix Curcumae, 39 parts of dried orange peel, fry 5 10 parts of Fructus Aurantii, 15 18 parts of inular flower, 10 15 parts of raddle, 5 10 parts of fructus amomi, 39 parts of radix glycyrrhizae, the Chinese medicine composition prepared by this method is safe and reliable, have no toxic side effect, it is quick, it is cheap, with reference to monarch make up a prescription mechanism carry out compatibility, with regulating qi-flowing for harmonizing stomach, the inverse effect of check is dropped, to stomach Qi rising, the circulation of vital energy in the wrong direction move every, on rush it is oh sound between caused larynx between larynx, sound it is short and frequency, the intractable hiccup for being difficult to self-control mainly to show has the effect of fine.
Description
Technical field
Patent of the present invention is related to a kind of Chinese medicine, especially a kind of Chinese medicine composition for treating intractable hiccup and its preparation side
Method, belongs to technical field of traditional Chinese medicines.
Background technology
Diaphragmatic spasm is called hiccup, is commonly called as having the hiccups, and is due to that diaphram, nervus phrenicus, vagus nerve or nervous centralis etc. are subject to
Cause the clonic spasm of side or bilateral diaphram after stimulation, closed suddenly with intake period glottis, send very brief loud spy
Other sound.Non- stopping person when if persistently spasm is small more than 48, claims intractable diaphragmatic spasm, is also intractable hiccup
(intractablehiccup,IH).Normal work, rest can be seriously affected if diaphragmatic spasm breaking-out is constant, if
It is can also have a significant impact with the breath function due of cardiopulmonary disease.Treatment method has an injection and medicinal treatment, but institute
It is larger that medicine is generally Western medicine toxic side effect, and easily recurs.
Doctor trained in Western medicine often with adjust electrolyte medicine, muscle relaxant, antipsychotic drug, antidepressants, central stimulant, calcium from
Sub- antagonist etc. is treated, its advantage is the rapid short time relief of symptoms of energy, but is often sent out again rapidly, effects a radical cure more difficult, prolonged and repeated use
Easily there is poisonous side effect of medicine in medicine, feelings of causing a disease conversion.Chinese Internal Medicine is generally adopted on the prescription of intractable hiccup illness at present
With the tuber of pinellia, cloves, the calyx and receptacle of a persimmon, caulis bambusae in taenian, inular flower etc., for regulating qi-flowing for harmonizing stomach, drop check is inverse, but existing Chinese medicine treatment prescription
Drawback is course of disease length, slowly effect, of high cost, negative effect is big；So for existing pathomechanism and principle-method-recipe-medicines, need
Understanding is further improved, improve and perfect treats the Chinese medicine composition of intractable hiccup.
The content of the invention
For the problems of the prior art, the invention aims to provide a kind of Chinese traditional medicine composition for treating intractable hiccup
Thing and preparation method thereof, the Chinese medicine composition prepared by this method is safe and reliable, has no toxic side effect, quick, cheap,
Carry out compatibility with reference to monarch mechanism of making up a prescription, there is regulating qi-flowing for harmonizing stomach, drops the inverse effect of check, the stomach Qi rising, circulation of vital energy in the wrong direction is moved every,
On rush oh sound between caused larynx between larynx, sound is short and frequency, it is difficult to make by oneself the intractable hiccup for being mainly show have it is good
Curative effect.
In order to achieve the above object, the technical scheme is that：
A kind of Chinese medicine composition for treating intractable hiccup, it is characterised in that the Chinese medicine composition by following parts by weight original
Material composition：7-15 parts of Angelica sinensis, 9-15 parts of stir-baked RADIX PAEONIAE ALBA, 5-10 parts of radix bupleuri, 8-15 parts of Poria cocos, 10-15 parts of ginseng, rhizoma atractylodis macrocephalae 10-15
Part, 6-10 parts of rhizoma cyperi, 5-9 parts of Radix Curcumae, 3-9 parts of dried orange peel, 5-10 parts of Fructus Aurantii of stir-fry, 15-18 parts of inular flower, 10-15 parts of raddle, sand
5-10 parts of benevolence, 3-9 parts of radix glycyrrhizae.
Preferably, which forms 10-14 parts of Angelica sinensis, stir-baked RADIX PAEONIAE ALBA 10-13 by the raw material of following parts by weight
Part, 7-9 parts of radix bupleuri, 10-13 parts of Poria cocos, 11-14 parts of ginseng, 11-14 parts of rhizoma atractylodis macrocephalae, 7-9 parts of rhizoma cyperi, 6-8 parts of Radix Curcumae, dried orange peel 4-
8 parts, fry 6-9 parts of Fructus Aurantii, 16-17 parts of inular flower, 11-14 parts of raddle, 6-9 parts of fructus amomi, 4-8 parts of radix glycyrrhizae.
Preferably, which is made of the raw material of following parts by weight：12 parts of Angelica sinensis, 13 parts of stir-baked RADIX PAEONIAE ALBA, bavin
8 parts recklessly, 12 parts of Poria cocos, 12 parts of ginseng, 12 parts of rhizoma atractylodis macrocephalae, 8 parts of rhizoma cyperi, 7 parts of Radix Curcumae, 6 parts of dried orange peel, fry 8 parts of Fructus Aurantii, inular flower
16 parts, 12 parts of raddle, 8 parts of fructus amomi, 7 parts of radix glycyrrhizae.
Preferably, which forms 12 parts of Angelica sinensis, 11 parts of stir-baked RADIX PAEONIAE ALBA, bavin by the raw material of following parts by weight
8 parts recklessly, 11 parts of Poria cocos, 12 parts of ginseng, 12 parts of rhizoma atractylodis macrocephalae, 8 parts of rhizoma cyperi, 7 parts of Radix Curcumae, 6 parts of dried orange peel, fry 7 parts of Fructus Aurantii, inular flower
17 parts, 12 parts of raddle, 8 parts of fructus amomi, 6 parts of radix glycyrrhizae.
Invention also provides a kind of preparation method of the Chinese medicine composition for the treatment of intractable hiccup as described above, its
It is characterized in that the preparation method includes the following steps：
1) Angelica sinensis, stir-baked RADIX PAEONIAE ALBA, radix bupleuri, Poria cocos, ginseng, rhizoma atractylodis macrocephalae, rhizoma cyperi, Radix Curcumae, dried orange peel, stir-fry trifoliate orange, are weighed by weight
Shell, inular flower, raddle, fructus amomi, radix glycyrrhizae, screening removal of impurities, larger raw material are cut into the fritter of soya bean size, exist after mixing
When sterilization treatment 1 is small under ultraviolet sterilizing lamp, it is subsequently placed in container and is soaked 60-100 minutes with normal-temperature water；
2), the Chinese medicine material after immersion and the water of immersion are placed in marmite, after boiling by intense fire, slow boiling heats 30 points
Clock, dries in the air after being down to 50-70 DEG C to temperature, takes filtrate, and the dregs of a decoction in marmite are spare, and filtrate is poured into container；
3), hot water will be added in the dregs of a decoction in marmite in step 2), carries out secondary decoction, first boil by intense fire, then be cooked by slow fire
20 minutes, dry in the air after being down to 50-70 DEG C to temperature, filter to obtain secondary liquid；
4), the liquid obtained in step 2) and step 3) is merged, and is uniformly mixed, bottles or packs after drying in the air to room temperature,
Obtain Traditional Chinese medicine composition liquid medicine.
The above method prepare be for traditional Chinese herbal decoction, the instructions of taking of this traditional Chinese herbal decoction：Take in three times within 1 day.Also can be 1 time
Property decoct the dose of 2 days, filling and sealing after obtained liquid is sterilized, refrigeration, first micro- heating when taking.This Chinese traditional medicine composition
Thing can also be prepared into powder capsule, and concrete scheme is as follows：
The preparation method of the Chinese medicine composition for the treatment of intractable hiccup as described above, it is characterised in that the preparation method bag
Include following steps：
1) Angelica sinensis, stir-baked RADIX PAEONIAE ALBA, radix bupleuri, Poria cocos, ginseng, rhizoma atractylodis macrocephalae, rhizoma cyperi, Radix Curcumae, dried orange peel, stir-fry trifoliate orange, are weighed by weight
Shell, inular flower, raddle, fructus amomi, radix glycyrrhizae, screening removal of impurities, larger raw material are cut into the fritter of soya bean size, exist after mixing
When sterilization treatment 1 is small under ultraviolet sterilizing lamp, powder is then ground to, after crossing 500-800 mesh sieves point, obtains herb powder；
2), the herb powder for obtaining step 1), which is fitted into capsule skin, is made Chinese medicinal capsule.
Further, the preparation method 1) granularity of herb powder that obtains in step is 600 mesh.
The Chinese medicine composition of the present invention has no toxic side effect, and therapeutic effect is good, treats both principal and secondary aspect of disease, uneasy to recur, particularly diet
Do not save, feelings will is unsuccessful, after being ill intractable hiccup caused by physically weak grade so that stomach Qi rising, the circulation of vital energy in the wrong direction that trigger move every, on rush between larynx
The patient's condition, have it is fine the effect of.All medicines share causes taste to adjust, in be so incensed that to mend, middle-jiao yang, function of the spleen and stomach rouses oneself, mechanism of qi and smooth, intractable
Hiccup removes certainly.
The Chinese medicine composition can be prepared into the diversified forms such as Chinese medicinal tablet, particle, traditional Chinese medicine pill, not limit to
For decoction and capsule, suitable for a variety of therapeutic modalities, application method.
The pharmacology of all kinds of Chinese medicines is as follows in the present invention：
Angelica sinensis：It is sweet in flavor, pungent, it is warm-natured.Return liver, the heart, the spleen channel.Effect：Replenishing and activating blood, menstruction regulating and pain relieving, relaxes bowel.Cure mainly：
For blood deficiency chlorosis, dizziness palpitaition, irregular menstruation, closed dysmenorrhea, asthenia cold abdominalgia, arthralgia pain due to rheumatism, injury from falling down, ulcer sores,
Dry constipation of intestines.Prepared RADIX ANGELICAE SINENSIS with yellow rice wine invigorate blood circulation.For closed dysmenorrhea, arthralgia pain due to rheumatism, injury from falling down.
Stir-baked RADIX PAEONIAE ALBA：Clean herbaceous peony is taken, is heated with slow boiling, is fried to surface yellow, taking-up is dried in the air cool, and stir-fry is delayed with property, soft liver, and
Spleen, antidiarrheal.Stir-baked RADIX PAEONIAE ALBA essence or Radix Paeoniae Alba after all, so it has analgesia, calm, anticonvulsant action, hepatoprotective effect, spasmolysis is made
With the effect such as improvement hemorheology.In general, raw Radix Paeoniae Alba pharmacological property is partially cold, there is relatively good smooth liver and relieve pain, hold back cloudy receipts sweat
The effect of, it is chiefly used in treating spontaneous sweating, fever due to yin deficiency, irregular menstruation, metrorrhagia and metrostaxis, the inferior illness of red leukorrhea.After frying
Radix Paeoniae Alba in albiflorin and the increase of benzoylpaeoniflorin content, cold weaken turn temperature, be mainly longer than blood-nourishing and hold back cloudy warm liver；Wine
Stir-baked RADIX PAEONIAE ALBA, be chiefly used in middle emergency, analgesic, be particularly advantageous for postpartum abdominal pain, be chiefly used in treat chest and abdomen pain over the hypochondriac region, rush down dysentery row
Through illnesss such as abdominal pain.
Radix bupleuri：Acrid flavour, hardship, cold nature.Return liver, courage, lung channel.In inducing diaphoresis, soothing liver-qi stagnation, yang invigorating, preventing malaria of bringing down a fever.
For cold, fever, fevers and chills alternate, distending pain in the chest and hypochondrium, irregular menstruation, the prolapse of uterus, rectal prolapse.
Poria cocos：It is sweet in flavor, light, it is mild-natured.The thoughts of returning home, lung, spleen, kidney channel.Effect：Clearing damp and promoting diuresis, invigorating the spleen, calming heart.Cure mainly：For water
Swollen oliguria, phlegm retention anti-dazzle nervous, spleen eating less, loose stool diarrhea, confused and worried, insomnia of palpitating with fear.
Ginseng：Sweet in flavor, slight bitter, it is warm-natured, flat.Returns spleen, lung channel, the heart channel of Hang-Shaoyin.Reinforce vital energy, veins takes off admittedly, reinforces the spleen to benefit the lung, raw
Tianjin, calms the nerves.Cure mainly：Physically weak to be taken off, cold weak pulse of limb, spleen eating less, the deficiency syndrome of the lung breathes with cough, and injury thirst, Heat Diabetes, prolonged illness void is thin,
Insomnia of palpitating with fear, impotence Gong Leng；Heart failure, cardiogenic shock.For dyspnea with shortness of breath, palpitation and amnesia, thirsty hidrosis, deficiency of food without
Power, all acute and chronic diseases and caused shock, collapse after losing blood.Reinforce vital energy, prevent prolapse and engender liquid, calms the nerves.It is deficient to control internal lesion caused by overexertion, eats
Few, burnout, regurgitation and emesis, lingering diarrhea of defecating, cough of deficient and syndrome characterized by dyspnea, spontaneous perspiration sudden collapse, palpitation with fear, forgetful, dizziness and headache, impotence, frequent micturition, disappears
Yearningly, woman uterine bleeding, infantile chronic fright, and perennial and irrecoverable weakness, the card of all qi-blood-body fluid deficiencies.
Rhizoma atractylodis macrocephalae：Rhizoma cyperi：Nature and flavor：Pungent, slight bitter, micro- sweet and neutral.Return liver, spleen, tri-jiao channel.Soothing liver-qi stagnation, regulating the flow of QI to ease the stomach, is adjusted
Meridian and relieving pain.For stagnation of QI due to depression of the liver, distending pain in the chest and hypochondrium, hernia pain, swollen breasts, the taste stagnation of the circulation of vital energy, gastral cavity abdomen ruffian is vexed, turgor pain, the moon
Through uncomfortable, closed dysmenorrhea.
Radix Curcumae：Nature and flavor：It is pungent, bitter, tremble with fear.Return liver, the heart, lung channel.Effect：Promoting blood circulation and stopping pain, promoting qi circulation and removing obstruction in the collateral, clear away heart-fire cool blood, cholagogic
Removing jaundice.Cure mainly：Go mad for chest side of body shouting pain, chest impediment and cardialgia, closed dysmenorrhea, swollen breasts, pyreticosis coma, epilepsy, blood-head tells nosebleed,
Jaundice.
Dried orange peel：It is bitter, pungent, it is warm-natured.Return lung, the spleen channel.Regulating qi-flowing for strengthening spleen is eliminating dampness and eliminating phlegm.For abdominal fullness and distention, deficiency of food is vomited and diarrhoea,
Coughing with a lot of sputum.
Fry Fructus Aurantii：Fry the processed product that Fructus Aurantii is Fructus Aurantii.It is faint yellow to fry Fructus Aurantii surface, occasionally there is focal spot, matter is crisp, and gas is fragrant, taste compared with
It is weak.Its high strong property can be relaxed by frying Fructus Aurantii, relatively qi-regulating stomach strengthening and digestion promoting.Eat and stagnate for place, inverse belch of vomitting, rubella itch [1].
Fructus Aurantii is fried because its effect relaxes, is suitable for being advanced in age and poor in health and stagnation of the circulation of vital energy person.Fructus Aurantii：Nature and flavor：Bitter, acid, be slightly cold.Enter spleen, stomach two passes through.Work(
Energy：Relieving stagnant Qi disperse accumulation, resolving sputum remove ruffian.Cure mainly：Dyspepsia phlegm is stagnant not to disappear, chest and abdomen feeling of fullness distending pain, stagnation of QI due to depression of the liver, the disease such as hypochondriac pain and diarrhea.
Inular flower：Nature and flavor：It is salty, temperature.Enter lung, liver, stomach.Major function：Dissolving phlegm, lower gas, softening hard masses, row water.Control phlegm in the heart
Knot, coerces lower turgor, cough and asthma, hiccup, saliva such as shellac varnish, epigastric fullness Ying, eructation unrelieved, extensive abdominal edema.
Raddle：Bitter, sweet, cold nature.Return liver, stomach, the heart channel of Hang-Shaoyin.Effect：Calming the liver, inverse, cooling blood and hemostasis drops in important city.It is main
Control：For having a headache, dizziness, palpitaition is demented, frightened epilepsy, and vomiting, gas, hiccup is dysphagic, coughs, and pants, and spits blood, nosebleed epistaxis, uterine bleeding,
Have blood in stool, hematuria.
Fructus amomi：Acrid flavour, it is warm-natured；Returns spleen, stomach, kidney channel.Major function：In promoting the circulation of qi tune, and stomach, it is amusing.Control abdominal pain swollen ruffian, stomach
Slow-witted food stagnation, dysphagic vomiting are cold to rush down cold dysentery, pregnant movement of the foetus.
Radix glycyrrhizae：It is sweet in flavor, it is mild-natured.The thoughts of returning home, lung, spleen, stomach.Effect：Invigorate the spleen and benefit qi, clearing heat and detoxicating, expelling phlegm and arresting coughing, emergency is stopped
Bitterly, coordinating the drug actions of a prescription.Cure mainly：For weakness of the spleen and the stomach, lassitude hypodynamia, palpitation, coughing with a lot of sputum, gastral cavity abdomen, four limbs contraction, carbuncle
Swollen sore, alleviates drug toxicity, strong.
" organic conception " is had been accepted as at present, " diagnosis and treatment based on an overall analysis of the illness and the patient's condition ", " compound use ", " compound compatibility medication is such as used military forces " are the traditional Chinese medical science
Most scientific most effective several big advantages, wherein " compound compatibility medication is such as used military forces " is the original theory of traditional Chinese medicine of very science.In
The tight compatibility that each medicine is all linked with one another as arraying troops for battle in prescription is cured, is that it is better than the effective means of western medicine formula.The traditional Chinese medical science
Prescription theory thinks that each prescription, not only needs to select the suitable appropriate compatibility of medicine according to etiology and pathogenesis, while should also accord with
Close the prescription compatibility theory of the basic structure of prescription, i.e. " monarch, minister, help, make ", the prescription compatibility of so-called " monarch, minister, help, make ", just
It is that it establishes the scientific matching on the comprehensive judgement basis to the disease interpretation of the cause, onset and process of an illness.Middle medical square is whole by too many levels, Mutiple Targets
The biological mechanism adjusted is closed, therapeutic effect more more longlasting than Western medicine, that more green natural has no toxic side effect can be obtained, and it is this
Curative effect is built upon on the original theoretical accurate instruction of above-mentioned traditional Chinese medical science tradition, and the present invention just have followed this principle.
Monarch drug in a prescription treats primary symptom in the side of referring to, plays the medicine of primary treatment, can use as required simply or a few taste medicines.Minister
Medicine is the medicine assisted main ingredient or strengthen main ingredient effect.Adjutant is the medicine for the toxicity assisted main ingredient treatment and disease or suppress main ingredient
Thing.It is that each medicine of guiding goes directly diseased region or the effect of each medicine of reconciling to make medicine.
The present invention is classified as monarch drug in a prescription with working as replenishing and activating blood, the bavin with the stir-baked RADIX PAEONIAE ALBA of tranquilizing to relieve muscle spasm and with soothing liver-qi stagnation in inducing diaphoresis
Act like a bully ministerial drug, with the Poria cocos of invigorating the spleen calming heart, the ginseng to reinforce the spleen to benefit the lung, the rhizoma atractylodis macrocephalae of strengthening the spleen and replenishing qi, the rhizoma cyperi of soothing liver-qi stagnation, promoting the circulation of qi
The Radix Curcumae of Xie Yu, qi regulating and spleen invigorating dried tangerine peel, qi-regulating stomach invigorating to fry the inular flower of gas under Fructus Aurantii, dissolving phlegm, calming the liver important city drop inverse
Raddle and promoting the circulation of qi tune in fructus amomi be adjutant, using the radix glycyrrhizae invigorated the spleen and benefited qi as medicine is made, have no toxic side effect, treatment intractable oh
Inverse, good effect is quick, treats both principal and secondary aspect of disease, and low-cost.
Embodiment
The present invention is further described with reference to embodiment.
Embodiment one：
A kind of Chinese medicine composition for treating intractable hiccup, it is characterised in that the Chinese medicine by following parts by weight raw material group
Into：15 parts of Angelica sinensis, 15 parts of stir-baked RADIX PAEONIAE ALBA, 10 parts of radix bupleuri, 15 parts of Poria cocos, 15 parts of ginseng, 15 parts of rhizoma atractylodis macrocephalae, 10 parts of rhizoma cyperi, Radix Curcumae 9
Part, 9 parts of dried orange peel, fry 10 parts of Fructus Aurantii, 18 parts of inular flower, 15 parts of raddle, 10 parts of fructus amomi, 9 parts of radix glycyrrhizae.
The present embodiment also discloses a kind of preparation method of the Chinese medicine composition for the treatment of intractable hiccup as described above,
It is characterized in that the preparation method includes the following steps：
1) 15 parts of Angelica sinensis, 15 parts of stir-baked RADIX PAEONIAE ALBA, 10 parts of radix bupleuri, 15 parts of Poria cocos, 15 parts of ginseng, rhizoma atractylodis macrocephalae, are weighed by weight
15 parts, 10 parts of rhizoma cyperi, 9 parts of Radix Curcumae, 9 parts of dried orange peel, fry 10 parts of Fructus Aurantii, 18 parts of inular flower, 15 parts of raddle, 10 parts of fructus amomi, radix glycyrrhizae 9
Part, screening removal of impurities, larger raw material is cut into the fritter of soya bean size, after mixing the sterilization treatment 1 under ultraviolet sterilizing lamp
Hour, it is subsequently placed in container and is soaked 60 minutes with normal-temperature water；
2), the Chinese medicine material after immersion and the water of immersion are placed in marmite, after boiling by intense fire, slow boiling heats 30 points
Clock, dries in the air after being down to 50 DEG C to temperature, takes filtrate, and the dregs of a decoction in marmite are spare, and filtrate is poured into container；
3), hot water will be added in the dregs of a decoction in marmite in step 2), carries out secondary decoction, first boil by intense fire, then be cooked by slow fire
20 minutes, dry in the air after being down to 50 DEG C to temperature, filter to obtain secondary liquid；
4), the liquid obtained in step 2) and step 3) is merged, and is uniformly mixed, bottles or packs after drying in the air to room temperature,
Obtain Traditional Chinese medicine composition liquid medicine.
Embodiment two
A kind of Chinese medicine composition for treating intractable hiccup, it is characterised in that the Chinese medicine composition by following parts by weight original
Material composition：10 parts of Angelica sinensis, 10 parts of stir-baked RADIX PAEONIAE ALBA, 7 parts of radix bupleuri, 10 parts of Poria cocos, 11 parts of ginseng, 11 parts of rhizoma atractylodis macrocephalae, 7 parts of rhizoma cyperi, Radix Curcumae 6
Part, 4 parts of dried orange peel, fry 6 parts of Fructus Aurantii, 16 parts of inular flower, 11 parts of raddle, 6 parts of fructus amomi, 4 parts of radix glycyrrhizae.
The present embodiment provides a kind of preparation method of the Chinese medicine composition for the treatment of intractable hiccup as described above at the same time,
It is characterized in that the preparation method includes the following steps：
1) 10 parts of Angelica sinensis, 10 parts of stir-baked RADIX PAEONIAE ALBA, 7 parts of radix bupleuri, 10 parts of Poria cocos, 11 parts of ginseng, rhizoma atractylodis macrocephalae 11, are weighed by weight
Part, 7 parts of rhizoma cyperi, 6 parts of Radix Curcumae, 4 parts of dried orange peel, 6 parts of Fructus Aurantii of stir-fry, 16 parts of inular flower, 11 parts of raddle, 6 parts of fructus amomi, 4 parts of radix glycyrrhizae, sieve
Dividing removal of impurities, larger raw material is cut into the fritter of soya bean size, when sterilization treatment 1 is small under ultraviolet sterilizing lamp after mixing,
Powder is then ground to, after crossing 500 mesh sieves point, obtains herb powder；
2), the herb powder for obtaining step 1), which is fitted into capsule skin, is made Chinese medicinal capsule.
Embodiment three：
A kind of Chinese medicine composition for treating intractable hiccup, it is characterised in that the Chinese medicine composition by following parts by weight original
Material composition：12 parts of Angelica sinensis, 13 parts of stir-baked RADIX PAEONIAE ALBA, 8 parts of radix bupleuri, 12 parts of Poria cocos, 12 parts of ginseng, 12 parts of rhizoma atractylodis macrocephalae, 8 parts of rhizoma cyperi, Radix Curcumae 7
Part, 6 parts of dried orange peel, fry 8 parts of Fructus Aurantii, 16 parts of inular flower, 12 parts of raddle, 8 parts of fructus amomi, 7 parts of radix glycyrrhizae.
The present embodiment provides a kind of preparation method of the Chinese medicine composition for the treatment of intractable hiccup as described above at the same time,
It is characterized in that the preparation method includes the following steps：
1) 12 parts of Angelica sinensis, 13 parts of stir-baked RADIX PAEONIAE ALBA, 8 parts of radix bupleuri, 12 parts of Poria cocos, 12 parts of ginseng, rhizoma atractylodis macrocephalae 12, are weighed by weight
Part, 8 parts of rhizoma cyperi, 7 parts of Radix Curcumae, 6 parts of dried orange peel, 8 parts of Fructus Aurantii of stir-fry, 16 parts of inular flower, 12 parts of raddle, 8 parts of fructus amomi, 7 parts of radix glycyrrhizae, sieve
Dividing removal of impurities, larger raw material is cut into the fritter of soya bean size, when sterilization treatment 1 is small under ultraviolet sterilizing lamp after mixing,
It is subsequently placed in container and is soaked 80 minutes with normal-temperature water；
2), the Chinese medicine material after immersion and the water of immersion are placed in marmite, after boiling by intense fire, slow boiling heats 30 points
Clock, dries in the air after being down to 60 DEG C to temperature, takes filtrate, and the dregs of a decoction in marmite are spare, and filtrate is poured into container；
3), hot water will be added in the dregs of a decoction in marmite in step 2), carries out secondary decoction, first boil by intense fire, then be cooked by slow fire
20 minutes, dry in the air after being down to 60 DEG C to temperature, filter to obtain secondary liquid；
4), the liquid obtained in step 2) and step 3) is merged, and is uniformly mixed, bottles or packs after drying in the air to room temperature,
Obtain Traditional Chinese medicine composition liquid medicine.
Example IV：
A kind of Chinese medicine composition for treating intractable hiccup, it is characterised in that the Chinese medicine composition by following parts by weight original
Material composition：12 parts of Angelica sinensis, 11 parts of stir-baked RADIX PAEONIAE ALBA, 8 parts of radix bupleuri, 11 parts of Poria cocos, 12 parts of ginseng, 12 parts of rhizoma atractylodis macrocephalae, 8 parts of rhizoma cyperi, Radix Curcumae 7
Part, 6 parts of dried orange peel, fry 7 parts of Fructus Aurantii, 17 parts of inular flower, 12 parts of raddle, 8 parts of fructus amomi, 6 parts of radix glycyrrhizae.
The present embodiment provides a kind of preparation method of the Chinese medicine composition for the treatment of intractable hiccup as described above at the same time,
It is characterized in that the preparation method includes the following steps：
1) 12 parts of Angelica sinensis, 11 parts of stir-baked RADIX PAEONIAE ALBA, 8 parts of radix bupleuri, 11 parts of Poria cocos, 12 parts of ginseng, rhizoma atractylodis macrocephalae 12, are weighed by weight
Part, 8 parts of rhizoma cyperi, 7 parts of Radix Curcumae, 6 parts of dried orange peel, 7 parts of Fructus Aurantii of stir-fry, 17 parts of inular flower, 12 parts of raddle, 8 parts of fructus amomi, 6 parts of radix glycyrrhizae, sieve
Dividing removal of impurities, larger raw material is cut into the fritter of soya bean size, when sterilization treatment 1 is small under ultraviolet sterilizing lamp after mixing,
Powder is then ground to, after crossing 600 mesh sieves point, obtains herb powder；
2), the herb powder for obtaining step 1), which is fitted into capsule skin, is made Chinese medicinal capsule.
Embodiment five：
A kind of Chinese medicine composition for treating intractable hiccup, it is characterised in that the Chinese medicine composition by following parts by weight original
Material composition：11 parts of Angelica sinensis, 10 parts of stir-baked RADIX PAEONIAE ALBA, 9 parts of radix bupleuri, 11 parts of Poria cocos, 12 parts of ginseng, 12 parts of rhizoma atractylodis macrocephalae, 8 parts of rhizoma cyperi, Radix Curcumae 7
Part, 6 parts of dried orange peel, fry 8 parts of Fructus Aurantii, 18 parts of inular flower, 12 parts of raddle, 9 parts of fructus amomi, 7 parts of radix glycyrrhizae.
The present embodiment provides a kind of preparation method of the Chinese medicine composition for the treatment of intractable hiccup as described above at the same time,
It is characterized in that the preparation method includes the following steps：
1) 11 parts of Angelica sinensis, 10 parts of stir-baked RADIX PAEONIAE ALBA, 9 parts of radix bupleuri, 11 parts of Poria cocos, 12 parts of ginseng, rhizoma atractylodis macrocephalae 12, are weighed by weight
Part, 8 parts of rhizoma cyperi, 7 parts of Radix Curcumae, 6 parts of dried orange peel, 8 parts of Fructus Aurantii of stir-fry, 18 parts of inular flower, 12 parts of raddle, 9 parts of fructus amomi, 7 parts of radix glycyrrhizae, sieve
Dividing removal of impurities, larger raw material is cut into the fritter of soya bean size, when sterilization treatment 1 is small under ultraviolet sterilizing lamp after mixing,
It is subsequently placed in container and is soaked 80 minutes with normal-temperature water；
2), the Chinese medicine material after immersion and the water of immersion are placed in marmite, after boiling by intense fire, slow boiling heats 30 points
Clock, dries in the air after being down to 70 DEG C to temperature, takes filtrate, and the dregs of a decoction in marmite are spare, and filtrate is poured into container；
3), hot water will be added in the dregs of a decoction in marmite in step 2), carries out secondary decoction, first boil by intense fire, then be cooked by slow fire
20 minutes, dry in the air after being down to 70 DEG C to temperature, filter to obtain secondary liquid；
4), the liquid obtained in step 2) and step 3) is merged, and is uniformly mixed, bottles or packs after drying in the air to room temperature,
Obtain Traditional Chinese medicine composition liquid medicine.
The present invention has carried out clinical efficacy tracking with the data given by embodiment 1 at the same time, and curative effect is summarized as follows：
1. selecting intractable hiccup patient 100, age 21-65 Sui, average age 46 years old, two groups are randomly divided into by patient,
There was no significant difference for the data such as treatment group 50, control group 50, two groups of ages, is comparable.Its common classical symptom
For hiccup, glottis closes send a kind of very brief sound suddenly during air-breathing, without other illnesss.Specifically show as oh having between larynx
Sound, sound is short and frequency, it is difficult to makes by oneself as main performance.
2. treatment method, treatment group takes orally Chinese medicine composition made from optimization formula embodiment 1 of the present invention, per bu sooner or later
Take twice, the course for the treatment of 25 days.Control group takes orally general treatment and is according to dosage taken daily with number with Western medicine, the course for the treatment of 25 days.
3. diagnostic criteria
Cure:Hiccup stops, without relapse indications in 3 months；
It is effective:Hiccup seizure frequency is few, and symptom duration is short, only even to have generation, does not influence to work normally and lives；
Effectively:Symptom of having the hiccups stops, but with frequency, interim breaking-out；
It is invalid:Unchanged before and after treatment, hiccup seizure frequency is more, duration length, hence it is evident that influences life and work.
4. treatment results, the cure rate for the treatment of group is 65%, effective 15%, effective 10%, invalid 10%, total effective rate
90%；The cure rate of control group is 20%, effective 18%, effective 22%, invalid 40%, total effective rate 60%.Treatment group owns
Follow-up of patients one month, does not have found recurrence sign.
The Chinese medicine of the present invention has carried out toxicity test, and test effect is as follows：
To choose that the suitable adult of weight is female, male each 20 of small white mouse, be divided into control group and administration group, rearing conditions are consistent,
Control group not medicine feed, the daily medicine feed of administration group 1 time, records the physical condition of each small white mouse, ingests, drinks water, weight daily, examination
Test lasting six months, compared with control group, administration group small white mouse physical condition, ingest, drink water, body weight increase it is normal, and not
See that small white mouse is sick or dead.Prompt the medicine security good, have no toxic side effect.
The treatment case of the Chinese medicine of the present invention is as follows：
Case one, gold certain, man, 65 years old.Hiccup 2 years, seriously affects diet and sleep, Western medicine, Chinese medicine are all used, curative effect
It is little, Chinese medicine provided by the invention is awarded, after a week, hiccup attack times significantly reduce and the duration substantially shortens, two weeks
Oh simply break out and will soon stop once in a while afterwards, after three weeks, hiccup disappears, and does not reaccess, and is after treatment, and medication one
Week.Visited after 1 year：Recovery from illness, no recurrence.
Case two, Liu, female, 56 years old.Hiccup 1 year, medical breaking-out for the previous period is frequent, pharynx is can't eat, to patient
The pain greatly born at heart with body is brought, awards Chinese medicine provided by the invention, after a week, hiccup attack times substantially subtract
Less and the duration substantially shortens, and after two weeks, hiccup disappears, and does not reaccess, and is after treatment, and medication one week.Chased after after 1 year
Visit：Recovery from illness, no recurrence.
Case three, Zhang, female, 35 years old, high-frequency hiccup symptom, more days of hospitalization, improved, has left hospital latter week,
Recurrence, is very worried, takes Chinese medicine provided by the invention, the second width starts to take effect, and is discontinued after continuously taking 15 days, nothing in January
Recurrence, then additional 15 days medicines, consolidate curative effect, visit 1 year no relapse.
Case four, is permitted certain, and female, 38 years old, suffers from intractable hiccup more than a year, and night on daytime is never interrupted, and winter is severe, is passed through
More local hospital therapies, intermittent attack, not except root, takes the decoction of above-described embodiment 1 after two days.
Case five, Zhao, man, 45 years old.Hiccup frequently breaks out 2 years, influences work with life in addition to sleep, oh repeatedly,
Make to stop less more, repeatedly see a doctor, curative effect is not shown.Take 2 gained Chinese medicinal capsule of the embodiment of the present invention to cure after 10 days, follow-up is not multiple
Hair.
Case six, Zhang, female is 76 years old, troubled by sickness and old age, and winter suffers from cold breaking-out after meal, hiccup repeatedly 2 days, day and night incessantly,
Red tongue moss white is shown in medical treatment, and veins string, in stomach during card category is cold, the hiccup real example of disorder of qi, warm water, massage is invalid, is cured after medical treatment
Institute takes half an hour after after writing a prescription and stops, and is recurred after two hours, continues still high-frequency recurrence after medication, takes the present invention's
After capsule, after 15 minutes hiccup stop, take three times in the morning, afternoon and evening, without relapse indications after continuous three days.
It is understood that above with respect to the specific descriptions of the present invention, it is merely to illustrate the present invention and is not limited to this
The described technical solution of inventive embodiments, it will be understood by those of ordinary skill in the art that, still the present invention can be carried out
Modification or equivalent substitution, to reach identical technique effect；As long as meet use needs, all protection scope of the present invention it
It is interior.
Claims (7)
- A kind of 1. Chinese medicine composition for treating intractable hiccup, it is characterised in that the Chinese medicine composition by following parts by weight raw material Composition：7-15 parts of Angelica sinensis, 9-15 parts of stir-baked RADIX PAEONIAE ALBA, 5-10 parts of radix bupleuri, 8-15 parts of Poria cocos, 10-15 parts of ginseng, 10-15 parts of rhizoma atractylodis macrocephalae, 6-10 parts of rhizoma cyperi, 5-9 parts of Radix Curcumae, 3-9 parts of dried orange peel, 5-10 parts of Fructus Aurantii of stir-fry, 15-18 parts of inular flower, 10-15 parts of raddle, fructus amomi 5-10 parts, 3-9 parts of radix glycyrrhizae.
- A kind of 2. Chinese medicine composition for treating intractable hiccup according to claim 1, it is characterised in that the Chinese traditional medicine composition Thing forms 10-14 parts of Angelica sinensis, 10-13 parts of stir-baked RADIX PAEONIAE ALBA, 7-9 parts of radix bupleuri, 10-13 parts of Poria cocos, ginseng by the raw material of following parts by weight 11-14 parts, 11-14 parts of rhizoma atractylodis macrocephalae, 7-9 parts of rhizoma cyperi, 6-8 parts of Radix Curcumae, 4-8 parts of dried orange peel, fry 6-9 parts of Fructus Aurantii, inular flower 16-17 Part, 11-14 parts of raddle, 6-9 parts of fructus amomi, 4-8 parts of radix glycyrrhizae.
- A kind of 3. Chinese medicine composition for treating intractable hiccup according to claim 1, it is characterised in that the Chinese traditional medicine composition Thing is made of the raw material of following parts by weight：12 parts of Angelica sinensis, 13 parts of stir-baked RADIX PAEONIAE ALBA, 8 parts of radix bupleuri, 12 parts of Poria cocos, 12 parts of ginseng, rhizoma atractylodis macrocephalae 12 parts, 8 parts of rhizoma cyperi, 7 parts of Radix Curcumae, 6 parts of dried orange peel, fry 8 parts of Fructus Aurantii, 16 parts of inular flower, 12 parts of raddle, 8 parts of fructus amomi, 7 parts of radix glycyrrhizae.
- A kind of 4. Chinese medicine composition for treating intractable hiccup according to claim 2, it is characterised in that the Chinese traditional medicine composition Thing forms 12 parts of Angelica sinensis, 11 parts of stir-baked RADIX PAEONIAE ALBA, 8 parts of radix bupleuri, 11 parts of Poria cocos, 12 parts of ginseng, rhizoma atractylodis macrocephalae by the raw material of following parts by weight 12 parts, 8 parts of rhizoma cyperi, 7 parts of Radix Curcumae, 6 parts of dried orange peel, fry 7 parts of Fructus Aurantii, 17 parts of inular flower, 12 parts of raddle, 8 parts of fructus amomi, 6 parts of radix glycyrrhizae.
- 5. a kind of preparation method of the Chinese medicine composition for the treatment of intractable hiccup as any one of claim 1-4, its It is characterized in that the preparation method includes the following steps：1) Angelica sinensis, stir-baked RADIX PAEONIAE ALBA, radix bupleuri, Poria cocos, ginseng, rhizoma atractylodis macrocephalae, rhizoma cyperi, Radix Curcumae, dried orange peel, stir-fry Fructus Aurantii, rotation, are weighed by weight Multiple flower, raddle, fructus amomi, radix glycyrrhizae, screening removal of impurities, larger raw material is cut into the fritter of soya bean size, after mixing ultraviolet When sterilization treatment 1 is small under line sterilamp, it is subsequently placed in container and is soaked 60-100 minutes with normal-temperature water；2), the Chinese medicine material after immersion and the water of immersion are placed in marmite, after boiling by intense fire, slow boiling heats 30 minutes, dries in the air After being down to 50-70 DEG C to temperature, filtrate is taken, the dregs of a decoction in marmite are spare, and filtrate is poured into container；3), hot water will be added in the dregs of a decoction in marmite in step 2), carries out secondary decoction, first boil by intense fire, then be cooked by slow fire 20 points Clock, dries in the air after being down to 50-70 DEG C to temperature, filters to obtain secondary liquid；4), the liquid obtained in step 2) and step 3) is merged, and is uniformly mixed, bottles or packs after drying in the air to room temperature, in obtaining Drug composition liquid.
- 6. a kind of preparation method of the Chinese medicine composition for the treatment of intractable hiccup as any one of claim 1-4, its It is characterized in that the preparation method includes the following steps：1) Angelica sinensis, stir-baked RADIX PAEONIAE ALBA, radix bupleuri, Poria cocos, ginseng, rhizoma atractylodis macrocephalae, rhizoma cyperi, Radix Curcumae, dried orange peel, stir-fry Fructus Aurantii, rotation, are weighed by weight Multiple flower, raddle, fructus amomi, radix glycyrrhizae, screening removal of impurities, larger raw material is cut into the fritter of soya bean size, after mixing ultraviolet When sterilization treatment 1 is small under line sterilamp, powder is then ground to, after crossing 500-800 mesh sieves point, obtains herb powder；2), the herb powder for obtaining step 1), which is fitted into capsule skin, is made Chinese medicinal capsule.
- A kind of 7. preparation method of Chinese medicine composition for treating intractable hiccup according to claim 6, it is characterised in that The preparation method 1) granularity of herb powder that obtains in step is 600 mesh.
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Application publication date: 20180413 |