CN107898535A - It is spaced cured artificial ligament - Google Patents

It is spaced cured artificial ligament Download PDF

Info

Publication number
CN107898535A
CN107898535A CN201711148600.2A CN201711148600A CN107898535A CN 107898535 A CN107898535 A CN 107898535A CN 201711148600 A CN201711148600 A CN 201711148600A CN 107898535 A CN107898535 A CN 107898535A
Authority
CN
China
Prior art keywords
weaving
weft yarn
length
artificial ligament
braiding layer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201711148600.2A
Other languages
Chinese (zh)
Inventor
万方
陈晓
陈世益
季杰
赖卫国
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shanghai Ligetai Biological Technology Co Ltd
Original Assignee
Shanghai Ligetai Biological Technology Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shanghai Ligetai Biological Technology Co Ltd filed Critical Shanghai Ligetai Biological Technology Co Ltd
Priority to CN201711148600.2A priority Critical patent/CN107898535A/en
Publication of CN107898535A publication Critical patent/CN107898535A/en
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/08Muscles; Tendons; Ligaments
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56Porous materials, e.g. foams or sponges
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2240/00Manufacturing or designing of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2240/001Designing or manufacturing processes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00Materials or treatment for tissue regeneration
    • A61L2430/10Materials or treatment for tissue regeneration for reconstruction of tendons or ligaments

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rehabilitation Therapy (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Materials For Medical Uses (AREA)
  • Dispersion Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Prostheses (AREA)
  • Cardiology (AREA)

Abstract

The present invention provides one kind to be spaced cured artificial ligament, include weaving (1), weaving (1) forms multiple cure on length extending direction and forms former ribbon (22) with (21), part of the weaving (1) between two neighboring cure with (21);The multiple band (21) that cures is taking turns flow arrangement with multiple former ribbons (22) along weaving (1) length direction;Equal length or presence between multiple original ribbons (22) is different;Weaving (1) includes braiding layer (31), the braiding layer (31) includes warp thread (310) and weft yarn, the warp thread (310) extends along weaving (1) width, and the weft yarn extends along weaving (1) length direction.The present invention can prevent the end of weaving from becoming loose when cutting out, and not only facilitate the suture of ligament reconstructive, but also can further prevent loose fiber particulate from dropping to cause inflammatory reaction.

Description

It is spaced cured artificial ligament
Technical field
The present invention relates to medical instruments field, and in particular, to one kind is spaced cured artificial ligament.
Background technology
When knee joint is overturned or turns up, the ligament being pulled tears beyond physiological stress, is broken equivalent damage, With knee joint swelling, pain, dysfunction, it is the disease mainly showed to have tender point etc..Knee stretch position, knee or lateral leg by Powerful violence strike or weight, make knee hyper-abduction, and medial collateral ligament can occur partially or completely to be broken.On the contrary, knee or leg Inner side is made knee Overadduction, lateral collateral ligament can occur partially or completely to be broken, in severe trauma by violence strike or weight When, collateral ligaments, ligamentum cruciatum and meniscus can damage at the same time.
Sprain of ankle joint is very common in injury gained in sports, and one of the most common is the supination damage of ankle, i.e., secondary on the outside of ankle Ligament injury, including anterior talofibular ligament, calcaneofibular ligament and posterior talofibular ligament damage.So-called supination damage, is in fact a connection Conjunction acts, including is received in the inward turning of ankle, heel distance boat joint varus and front foot, is difficult to isolate to come in damage process.Moving In, body loses center of gravity for some reason, or takeoff landing when step on others' foot, or foot is stepped on to be stumbled etc. and all may be used during exercise The action of sufficient supination can be produced, causes the lateral ligament of ankle damage of ankle.
Treatment for collateral ligament trauma, when ligament is from stop avulsion, it is difficult to when directly suturing, ligament stop should be carried out Reconstruction.Needing to use artificial collateral ligaments at this time, collateral ligaments product length on the market is 400mm, 500mm at present, 600mm or 800mm, in actual clinical in use, doctor needs for collateral ligaments to be cut into the length of needs, and collateral ligaments is one The strip fabrics of kind braiding structure, when being cut with scissors, its end can be loose, the more difficult suture of ligament reconstructive, and loose fiber Easily fall particulate, easily cause inflammatory reaction.
The content of the invention
For in the prior art the defects of, the object of the present invention is to provide one kind to be spaced cured artificial ligament.
The cured artificial ligament in interval provided according to the present invention, comprising weaving, weaving is formed on length extending direction Multiple curing bands, part of the weaving between two neighboring curing band form former ribbon;
The multiple curing band is taking turns flow arrangement with multiple former ribbons along weaving length direction;Between multiple original ribbons Equal length exists different;
Weaving includes braiding layer, and the braiding layer includes warp thread and weft yarn, and the warp thread extends along weaving width, institute Weft yarn is stated along weaving length direction to extend.
Preferably, the weaving also includes collagen film;
The collagen film is connected on one of end face of two end faces of braiding layer through-thickness or whole two On a end face.
Preferably, the weft yarn includes the first weft yarn and the second weft yarn;
First weft material is degradation material, and the second weft material is non-degradable material, is prolonged along weaving width Stretch on direction, the first weft yarn and the second weft yarn wheel flow arrangement or be sequentially arranged.
Preferably, the former ribbon includes longitude and latitude soft ribbons and weft soft ribbons;
The braiding layer of the longitude and latitude soft ribbons includes warp thread and weft yarn, and the braiding layer of the weft soft ribbons only includes weft yarn.
Preferably, on the length extending direction along weaving, curing strip length is 3~10mm, former webbing length for 10~ 50mm。
Preferably, the collagen film is connected in braiding layer by following any mode:
-- fitting;
-- spraying;
-- suture.
Preferably, the material of the warp thread and weft yarn is following any or appoints a variety of:
-- collagen and polyvinyl alcohol composite monofilament;
-- collagen and polyvinyl alcohol compound multifilament yarn;
-- polylactic acid base polymer monofilament;
-- polylactic acid base polymer multifilament.
Compared with prior art, the present invention has following beneficial effect:
1st, the present invention can prevent the end of weaving from becoming loose when cutting out, and not only facilitate the suture of ligament reconstructive, and And it can further prevent loose fiber particulate from dropping to cause inflammatory reaction;
2nd, after the present invention cuts suitable length according to demand, remaining part keeps the stabilization of form, thus still is able to It is utilized, significantly reduces costs;
3rd, the collagen film in the present invention is a kind of natural activity albumen, has relatively low immunogenicity, good life Thing compatibility and histocompatbility, itself and its catabolite are nontoxic to cell and body, will not or it is less cause inflammation and Immunological rejection;
4th, braiding layer is polyalcohol stephanoporate fabric in the present invention, plays mechanical support, using the teaching of the invention it is possible to provide higher machinery is strong Degree.
Brief description of the drawings
Upon reading the detailed description of non-limiting embodiments with reference to the following drawings, further feature of the invention, Objects and advantages will become more apparent upon:
Thickness direction structure diagram when Fig. 1 includes collagen film for weaving;
Fig. 2 is schematic structural view of the invention;
When Fig. 3 includes weft soft ribbons for weaving, the first weft and the second weft are sequentially arranged structure diagram;
When Fig. 4 includes weft soft ribbons for weaving, the first weft and the second weft arrangement schematic diagram in turn.
Shown in figure:
Embodiment
With reference to specific embodiment, the present invention is described in detail.Following embodiments will be helpful to the technology of this area Personnel further understand the present invention, but the invention is not limited in any way.It should be pointed out that the ordinary skill to this area For personnel, without departing from the inventive concept of the premise, various modifications and improvements can be made.These belong to the present invention Protection domain.
In the description of the present invention, it is to be understood that term " on ", " under ", "front", "rear", "left", "right", " perpendicular Directly ", the orientation of the instruction such as " level ", " top ", " bottom ", " interior ", " outer " or position relationship are based on orientation shown in the drawings or position Relation is put, it is of the invention necessary with simplified description, rather than the device or element of instruction or hint meaning to be for only for ease of description With specific orientation, with specific azimuth configuration and operation, therefore be not considered as limiting the invention.
As shown in Fig. 2, in embodiment, the cured artificial ligament in interval provided by the invention includes weaving 1, and weaving 1 is in length Multiple curing bands 21 are formed on degree extending direction, part of the weaving 1 between two neighboring curing band 21 forms former ribbon 22, institute State multiple curing bands 21 and take turns flow arrangement along 1 length direction of weaving with multiple former ribbons 22.In the length extension side along weaving 1 Upwards, it is 3~10mm to cure 21 length of band, and former 22 length of ribbon is 10~50mm, and the length of multiple original ribbons 22 has difference, When doctor needs the braid over braid of length-specific, it need to only cure at suitable two on band 21 and be cut out, certainly preferably In example, the length of former ribbon 22 can also be equal, so process it is relatively simple, but in the clip length of braid over braid Selection on accordingly can be insufficient.
As shown in Figure 1, weaving 1 includes braiding layer 31 and collagen film 32, the collagen film 32 is connected to braiding On one of end face of 31 through-thickness of layer, two end faces or on whole two end faces.Collagen film 32 passes through Static Spinning It is processed into, and is processed by way of spraying, suturing or directly fit in braiding layer 31.The braiding layer 31 includes warp Yarn 310 and weft yarn, the warp thread 310 extend along 1 width of weaving, and the weft yarn extends along knitted body length direction, implement In example, the material of warp thread 310 and weft yarn is following any or appoints a variety of:Collagen is with polyvinyl alcohol composite monofilament, collagen with gathering Vinyl alcohol compound multifilament yarn, polylactic acid base polymer monofilament, polylactic acid base polymer multifilament, specifically, such as PLLA, PLGA, The materials such as PGLA, PGA.In change case, the weaving 1 is only made of braiding layer 31.It is as shown in Figure 3, Figure 4, described in preference Former ribbon 22 includes longitude and latitude soft ribbons 221 and weft soft ribbons 222, and the braiding layer 31 of the longitude and latitude soft ribbons 221 includes warp thread 310 and latitude Yarn, the braiding layer 31 of the weft soft ribbons 222 only include weft yarn, and in use, weft soft ribbons 222 are located in articular cavity, Since rigidity is relatively low, it is more suitable for the activity in joint;Preferably, processed by collagen film 32 when in braiding layer 31, Covering collagen film 32 is not had in weft soft ribbons 222.Preferably, the weft yarn includes the first weft yarn 311 and the second weft yarn 312,311 material of the first weft yarn is degradation material, and 312 material of the second weft yarn is non-degradable material, along 1 width of weaving On extending direction, the first weft yarn 311 is taken turns flow arrangement with the second weft yarn 312 or is sequentially arranged.
Curing band 21 in weaving 1 be melted by blanching or ultrasonic heat it is standby, make braid over braid hot melt cure, when in use, As needed, certain length is cut into, crop position is the curing band 21, crop position is occurred without loose fiber.This hair Bright middle weaving 1 includes the following two kinds structure:The first is only to include braiding layer 31;Second includes braiding layer 31 and glue at the same time Collagen film 32.The processing of the first structure is simple, can be greatly saved production cost while therapeutic effect is reached;Second Structure is after implanting, and as collagen film 32 is gradually degraded, human body itself connective tissue is grown into micro- into ligament Hole, forms overall structure, accelerates wound healing., can be with and braiding layer 31 is because of its excellent mechanical strength and good compliance It is kept mechanically stable in activity repeatedly, recover joint motion, while with the growth of itself connective tissue, braiding layer 31 Gradually slowly degraded, combines together with tissue, so as to reach comparatively ideal ligament reconstructive reparation.
The specific embodiment of the present invention is described above.It is to be appreciated that the invention is not limited in above-mentioned Particular implementation, those skilled in the art can make various deformations or amendments within the scope of the claims, this not shadow Ring the substantive content of the present invention.In the case where there is no conflict, the feature in embodiments herein and embodiment can any phase Mutually combination.

Claims (7)

1. one kind is spaced cured artificial ligament, it is characterised in that includes weaving (1), weaving (1) shape on length extending direction Cure band (21) into multiple, part of the weaving (1) between two neighboring cure with (21) forms former ribbon (22);
The multiple band (21) that cures is taking turns flow arrangement with multiple former ribbons (22) along weaving (1) length direction;Multiple originals are knitted With the equal length between (22) or exist different;
Weaving (1) includes braiding layer (31), and the braiding layer (31) includes warp thread (310) and weft yarn, and warp thread (310) edge is knitted Cloth (1) width extends, and the weft yarn extends along weaving (1) length direction.
2. the cured artificial ligament in interval according to claim 1, it is characterised in that the weaving (1) also includes collagen Protein film (32);
The collagen film (32) is connected on one of end face of two end faces of braiding layer (31) through-thickness or complete On two, portion end face.
3. the cured artificial ligament in interval according to claim 1 or 2, it is characterised in that the weft yarn includes the first latitude Yarn (311) and the second weft yarn (312);
First weft yarn (311) material is degradation material, and the second weft yarn (312) material is non-degradable material, along weaving (1) on width extending direction, the first weft yarn (311) is taken turns flow arrangement with the second weft yarn (312) or is sequentially arranged.
4. the cured artificial ligament in interval according to claim 1 or 2, it is characterised in that the original ribbon (22) includes Longitude and latitude soft ribbons (221) and weft soft ribbons (222);
The braiding layer (31) of the longitude and latitude soft ribbons (221) includes warp thread (310) and weft yarn, the braiding of the weft soft ribbons (222) Layer (31) only includes weft yarn.
5. the cured artificial ligament in interval according to claim 1 or 2, it is characterised in that prolong in the length along weaving (1) Stretch on direction, it is 3~10mm to cure band (21) length, and former ribbon (22) length is 10~50mm.
6. the cured artificial ligament in interval according to claim 2, it is characterised in that the collagen film (32) passes through Any mode is connected in braiding layer (31) below:
-- fitting;
-- spraying;
-- suture.
7. the cured artificial ligament in interval according to claim 1, it is characterised in that the warp thread (310) and weft yarn Material is following any or appoints a variety of:
-- collagen and polyvinyl alcohol composite monofilament;
-- collagen and polyvinyl alcohol compound multifilament yarn;
-- polylactic acid base polymer monofilament;
-- polylactic acid base polymer multifilament.
CN201711148600.2A 2017-11-17 2017-11-17 It is spaced cured artificial ligament Pending CN107898535A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201711148600.2A CN107898535A (en) 2017-11-17 2017-11-17 It is spaced cured artificial ligament

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201711148600.2A CN107898535A (en) 2017-11-17 2017-11-17 It is spaced cured artificial ligament

Publications (1)

Publication Number Publication Date
CN107898535A true CN107898535A (en) 2018-04-13

Family

ID=61846289

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201711148600.2A Pending CN107898535A (en) 2017-11-17 2017-11-17 It is spaced cured artificial ligament

Country Status (1)

Country Link
CN (1) CN107898535A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108529739A (en) * 2018-04-25 2018-09-14 上海翰锦生物科技有限公司 A kind of porosity complex microorganism carrier and preparation method thereof
CN111450316A (en) * 2020-03-04 2020-07-28 东华大学 Integrated bracket for simulating bone-tendon-bone mineralization-non-mineralization gradient structure

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2688691A1 (en) * 1992-03-19 1993-09-24 Cendis Medical Artificial ligament for consolidation or replacement
CN1371664A (en) * 2001-02-28 2002-10-02 上海市黄浦区中心医院 Multi-layer structured artificial ligament with external covered biological film
CN2860404Y (en) * 2005-09-29 2007-01-24 上海市黄浦区中心医院 Composite felt artificial ligament
CN106955371A (en) * 2016-01-11 2017-07-18 苏州微创脊柱创伤医疗科技有限公司 A kind of artificial soft tissue's braid and its production and use
CN208892858U (en) * 2017-11-17 2019-05-24 上海利格泰生物科技有限公司 It is spaced cured artificial ligament

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2688691A1 (en) * 1992-03-19 1993-09-24 Cendis Medical Artificial ligament for consolidation or replacement
CN1371664A (en) * 2001-02-28 2002-10-02 上海市黄浦区中心医院 Multi-layer structured artificial ligament with external covered biological film
CN2860404Y (en) * 2005-09-29 2007-01-24 上海市黄浦区中心医院 Composite felt artificial ligament
CN106955371A (en) * 2016-01-11 2017-07-18 苏州微创脊柱创伤医疗科技有限公司 A kind of artificial soft tissue's braid and its production and use
CN208892858U (en) * 2017-11-17 2019-05-24 上海利格泰生物科技有限公司 It is spaced cured artificial ligament

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108529739A (en) * 2018-04-25 2018-09-14 上海翰锦生物科技有限公司 A kind of porosity complex microorganism carrier and preparation method thereof
CN108529739B (en) * 2018-04-25 2021-03-05 上海祺宇生物科技有限公司 Porous composite microbial carrier and preparation method thereof
CN111450316A (en) * 2020-03-04 2020-07-28 东华大学 Integrated bracket for simulating bone-tendon-bone mineralization-non-mineralization gradient structure

Similar Documents

Publication Publication Date Title
US11938017B2 (en) Tissue augmentation scaffolds for use in soft tissue fixation repair
CN109561893A (en) The tissue being used together with the fixed repair system of soft tissue with method enhances structure
JP4194774B2 (en) Bioprosthesis device
ES2651419T3 (en) Device for repair or replacement of soft tissue
EP2175800B1 (en) Composite implant for surgical repair
CN103764068A (en) Umbilical hernia prosthesis
CN109009280A (en) Tissue for the fixed repair system of soft tissue and method enhances tack
CN107898535A (en) It is spaced cured artificial ligament
CN107405425A (en) It is laminated tissue transplantation product
US10648109B2 (en) Pliable silk medical device
CN208892858U (en) It is spaced cured artificial ligament
US20130253646A1 (en) Silk based implantable medical devices and methods for determining suitability for use in humans
CN107898534B (en) Absorbable ligament with curing band
US20230055112A1 (en) Collagen Construct and Method for Producing the Collagen Construct
US20220346926A1 (en) Systems and methods for using structured tissue augmentation constructs in soft tissue fixation repair
CN208864571U (en) With the absorbable ligament for solidifying band
US10368992B2 (en) Resorbable and biocompatible graft in PGA for implant following excision of the IPP plaque
CN107854194A (en) The absorbable composite patch and manufacture method repaired for shoulder sleeve
CN208864572U (en) Ankle-joint artificial ligament
CN107961099B (en) Ligament with curing strap
US20130116711A1 (en) Silk based implantable medical devices and methods for determining suitability for use in humans
CN113633827A (en) Silk woven meniscus implant and preparation method thereof
CN209091738U (en) With the ligament for solidifying band
CN208864566U (en) Absorbable composite patch for rotator cuff reparation
CN108125731B (en) Ankle joint artificial ligament

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
CB02 Change of applicant information
CB02 Change of applicant information

Address after: 201700 Room 301, Building 1, No. 508 Tianchen Road, Qingpu District, Shanghai

Applicant after: Shanghai Ligetai Biotechnology Co.,Ltd.

Address before: 201700 Room 301, Building 1, No. 508 Tianchen Road, Qingpu District, Shanghai

Applicant before: SHANGHAI LIGETAI BIOLOGICAL TECHNOLOGY Co.,Ltd.

RJ01 Rejection of invention patent application after publication
RJ01 Rejection of invention patent application after publication

Application publication date: 20180413