CN107887099B - Anastomosis device based on temperature-control self-adaptive magnetic composite material for micro-wound anastomosis - Google Patents

Anastomosis device based on temperature-control self-adaptive magnetic composite material for micro-wound anastomosis Download PDF

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Publication number
CN107887099B
CN107887099B CN201711107933.0A CN201711107933A CN107887099B CN 107887099 B CN107887099 B CN 107887099B CN 201711107933 A CN201711107933 A CN 201711107933A CN 107887099 B CN107887099 B CN 107887099B
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China
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composite material
magnetic
anastomosis
magnetic composite
magnet
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CN201711107933.0A
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CN107887099A (en
Inventor
严小鹏
吕毅
赵广宾
史爱华
马锋
乔伟
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Chonghao Technology Co.,Ltd.
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First Affiliated Hospital of Medical College of Xian Jiaotong University
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    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
    • H01F1/00—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties
    • H01F1/44—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of magnetic liquids, e.g. ferrofluids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/11—Surgical instruments, devices or methods, e.g. tourniquets for performing anastomosis; Buttons for anastomosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
    • A61L17/04—Non-resorbable materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
    • A61L17/06—At least partially resorbable materials
    • A61L17/10—At least partially resorbable materials containing macromolecular materials
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
    • H01F41/00—Apparatus or processes specially adapted for manufacturing or assembling magnets, inductances or transformers; Apparatus or processes specially adapted for manufacturing materials characterised by their magnetic properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00831—Material properties
    • A61B2017/00876—Material properties magnetic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/06—Flowable or injectable implant compositions

Abstract

A temperature-controlled self-setting magnetic composite material for micro-wound anastomosis is prepared from the particles of permanent-magnetic material, sodium alginate solution and gelatin particles through proportionally mixing, injecting the magnetic composite material into the hollow organ to be anastomosed by a puncture tube, arranging the anchoring magnet in the hollow organ to be anastomosed, forming a certain shape by the magnetic composite material under the action of magnetic field, and gradually fixing the shape along with the change of temp difference to obtain a solid magnet, thereby completing magnetic pressing anastomosis and realizing minimally invasive implantation of magnetic materials at one side.

Description

Anastomosis device based on temperature-control self-adaptive magnetic composite material for micro-wound anastomosis
Technical Field
The invention belongs to the technical field of medical materials, and particularly relates to a temperature-control self-setting magnetic composite material for minimally invasive lower anastomosis, a preparation method thereof and an anastomosis system thereof.
Background
The magnetic pressing anastomosis technology can realize the anastomosis reconstruction between the hollow viscera by means of the magnetic attraction between two or more magnets, and has the advantages of simple operation, short anastomosis time, reliable anastomosis effect and the like. At present, most of magnets used for magnetic pressing anastomosis are machined into various fixed shapes such as circular ring, cylinder, elliptical ring, strip and the like. To overcome this drawback, deformable magnetic devices such as "discontinuous deformable surgical anastomosis ring (patent No. 201210000963.2)", "modular magnetic anastomosis device (patent No. 201280040553.9)" and the like have been invented. While such designs can greatly reduce the space required for magnet placement, they have not been able to fully exploit the minimally invasive surgical concept.
Disclosure of Invention
In order to overcome the defects of the prior art, the invention aims to provide a temperature-controlled self-setting magnetic composite material for micro-wound anastomosis, a preparation method thereof and an anastomosis system thereof, which can realize the micro-invasion of one-side magnetic material implantation.
In order to achieve the purpose, the invention adopts the technical scheme that:
a temperature control self-setting magnetic composite material for micro-wound anastomosis is mainly prepared from permanent magnetic material particles, sodium alginate solution with mass concentration of 0.1-5%, and gelatin particles according to the weight ratio of (1-20): (0.2-1) mL: (0.005-2) g.
The permanent magnetic particle material is formed by ball milling of a permanent magnetic material, and the diameter of the particles is micron.
The permanent magnet material is neodymium iron boron, ferroferric oxide or samarium cobalt and the like.
The invention also provides a preparation process of the temperature-control self-setting magnetic composite material for micro-wound anastomosis, which comprises the following steps:
step 1, adding sterile deionized water into sodium alginate powder treated by an ethylene oxide sterilization method, and fully dissolving the sodium alginate powder in a water bath environment at 30-85 ℃ to prepare a sodium alginate solution with the mass concentration of 0.1-5%;
and 2, mixing the sterilized gelatin particles and the obtained sodium alginate solution according to the weight ratio of (0.005-2) g: (0.2-1) mL, fully oscillating and uniformly mixing;
and 3, adding 1-20g of the sterilized permanent magnet particle material into the solution obtained in the step 2, and fully stirring and uniformly mixing.
The invention also provides an anastomosis system based on the temperature-controlled self-type magnetic composite material for the minimally invasive anastomosis, which comprises the following components:
the magnetic composite material;
an injection device for injecting the magnetic composite material;
and an anchoring magnet for guiding the setting of the magnetic composite material.
The injection device injects the magnetic composite material into the hollow organ on one side to be anastomosed by means of a puncture pipeline, the anchoring magnet is pre-retained in the hollow organ on the opposite side, the magnetic composite material forms a certain shape under the action of a magnetic field of the anchoring magnet, and the formed shape is gradually fixed along with the change of temperature difference, so that a solid magnet is formed.
The anchoring magnet may be a cylinder, a ring, a bar, or the like.
The anchoring magnet can be machined and formed by adopting a ferrite material, a samarium cobalt material, a neodymium iron boron material or an aluminum nickel cobalt permanent magnet material.
The surface of the anchoring magnet is treated by adopting surface treatment methods such as nickel plating, zinc plating, nickel-copper-nickel plating, titanium nitride plating, diamond plating or polytetrafluoroethylene plating and the like.
Compared with the existing magnetic anastomosis technology, the temperature sensitive flowing state magnetic composite material is prepared and injected into the cavity at one side to be anastomosed by a puncture injection method, the flowing state magnetic composite material is attracted with an anchoring magnet pre-retained in the visceral organ at the other side to be anastomosed and automatically forms a certain shape, and the magnetic composite material can be solidified to form a magnet with a certain shape along with the change of the external temperature, so that the magnetic pressing anastomosis is completed, and the minimally invasive implantation of the magnetic material at one side is realized.
Drawings
Fig. 1 shows a site to be operated on in an embodiment of the present invention.
FIG. 2 shows an anchoring magnet of an embodiment of the present invention pre-placed in place in the body.
Fig. 3 shows the injection device according to the embodiment of the present invention injecting the magnetic composite material into the hollow organ to be anastomosed by means of the puncture tube.
Fig. 4 shows an embodiment of the present invention where the magnetic composite material is self-shaping and forms a solid state magnet.
Fig. 5 shows that after the pressing anastomosis of the embodiment of the invention is completed, the anchoring magnet and the formed solid magnet are closely attracted into the stomach, and the anastomotic orifice is formed.
Detailed Description
The embodiments of the present invention will be described in detail below with reference to the drawings and examples.
The invention relates to a temperature-control self-setting magnetic composite material for micro-wound anastomosis, and a preparation process and application thereof, wherein the preparation process comprises the following steps:
step 1, adding sterile deionized water into sodium alginate powder treated by an ethylene oxide sterilization method, and fully dissolving the sodium alginate powder in a water bath environment at 30-85 ℃ to prepare a sodium alginate solution with the mass concentration of 0.1-5%;
and 2, mixing the sterilized gelatin particles and the obtained sodium alginate solution according to the weight ratio of (0.005-2) g: (0.2-1) mL, fully oscillating and uniformly mixing;
and 3, adding 1-20g of the sterilized permanent magnet particle material into the solution, and fully stirring and uniformly mixing.
The magnetic composite material can realize minimally invasive anastomosis, an injection device is used for extracting a proper amount of the magnetic mixed material, the magnetic mixed material is injected into a hollow organ on one side to be anastomosed by means of a puncture pipeline, the magnetic composite material can form a certain shape under the action of a magnetic field of an anchoring magnet pre-retained in the hollow organ on the opposite side, and the formed shape is gradually immobilized along with the change of temperature difference, so that a solid magnet is formed.
Taking a pancreatic tail pseudocyst operation as an example, the specific process is as follows:
as shown in figure 1, pseudocyst 3 is present in the tail of pancreas 2 and requires surgery.
As shown in fig. 2, the anchoring magnet 4 is swallowed into the stomach 1 orally.
As shown in fig. 3, the puncture needle 5 penetrates into the pseudocyst of pancreatoduodenum 3 and pushes the magnetic composite material 6.
As shown in fig. 4, under the magnetic attraction of the anchor magnet 4, the magnetic composite material 6 self-shapes and forms a solid magnet 7, and the anchor magnet 4 and the solid magnet 7 attract each other to press the wall of the stomach 1 and the wall of the pancreatic caudal pseudocyst 3.
As shown in fig. 5, after the pressing anastomosis is completed, the anchoring magnet 4 and the solid magnet 7 are closely attracted into the stomach 1, and can be automatically discharged out of the body through the digestive tract, and an anastomosis 8 is formed.

Claims (5)

1. Anastomosis device based on a temperature-controlled self-conforming magnetic composite material for microtrauma, comprising:
the magnetic composite material is prepared from permanent magnetic material particles, 0.1-5% sodium alginate solution and gelatin particles (1-20 g): (0.2-1) mL: (0.005-2) g;
an injection device for injecting the magnetic composite material;
and an anchor magnet for guiding the magnetic composite material to be shaped, wherein the magnetic composite material forms a certain shape under the action of a magnetic field of the anchor magnet, and the formed shape is gradually fixed along with the change of temperature difference, so that a solid magnet is formed.
2. The anastomosis device according to claim 1, wherein said anchoring magnet is cylindrical, circular or bar-shaped.
3. The anastomosis device according to claim 1, wherein the anchoring magnet is formed from a permanent magnetic material.
4. The anastomosis device of claim 3, wherein the permanent magnetic material is a ferrite material, a samarium cobalt material, a neodymium iron boron material, or an alnico material.
5. The anastomosis device according to claim 3 or 4, wherein the surface of the anchoring magnet is treated with a surface treatment method of nickel plating, zinc plating, nickel-copper-nickel plating, titanium nitride plating, diamond-like plating or polytetrafluoroethylene plating.
CN201711107933.0A 2017-11-10 2017-11-10 Anastomosis device based on temperature-control self-adaptive magnetic composite material for micro-wound anastomosis Active CN107887099B (en)

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CN110403661B (en) * 2018-04-27 2021-06-08 西安交通大学医学院第一附属医院 Bionical driven alimentary canal magnetism anastomosis device of wheat mango
CN109223129B (en) * 2018-10-09 2020-11-10 西安交通大学医学院第一附属医院 Magnetic anchoring puncture assembly for endoscopic lower gastrointestinal anastomosis
CN110269657B (en) * 2019-06-12 2021-07-06 西安交通大学医学院第一附属医院 High-position magnetic biliary-enteric anastomosis device
CN213048326U (en) * 2020-03-26 2021-04-27 西安交通大学医学院第一附属医院 Injection device for preoperative positioning of pulmonary nodules

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