CN107860788A - A kind of collagenous fibres class biomaterial thermal contraction performance detection device and application - Google Patents
A kind of collagenous fibres class biomaterial thermal contraction performance detection device and application Download PDFInfo
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- CN107860788A CN107860788A CN201711056629.8A CN201711056629A CN107860788A CN 107860788 A CN107860788 A CN 107860788A CN 201711056629 A CN201711056629 A CN 201711056629A CN 107860788 A CN107860788 A CN 107860788A
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N25/00—Investigating or analyzing materials by the use of thermal means
- G01N25/16—Investigating or analyzing materials by the use of thermal means by investigating thermal coefficient of expansion
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Abstract
The present invention provides a kind of detection device of thermal contraction performance after detection collagenous fibres class biomaterial crosslinking reasonable in design, accurate is strengthened, and it is applied to the thermal contraction performance that detection is crosslinked the protein structure of strengthened collagenous fiber material using distinct methods.Collagenous fibres are after distinct methods are crosslinked, it is heated reach certain temperature after its macromolecule protein structure brisement is shunk in different time moment according to its degree of stability, and the temperature of this instantaneous variation, the power of collagenous fibres class biomaterial intermolecular cross-linking is reflected indirectly, so as to express different anti-degradation properties of the material to clostridiopetidase A.The detection device that the invention is related to is used for the thermal contraction performance for characterizing collagenous fibres class biomaterial, with originality, its high sensitivity, small, composition is simple, easy to use, suitable for detect with the sheet of three-dimensional structure, bulk, column, strip, tubulose collagenous fibres class biomaterial thermal contraction performance.
Description
Technical field
The present invention relates to the technical fields such as biomaterial, mechanical engineering, more particularly to a kind of collagenous fibres class to give birth to
Thing material thermal contraction performance detection device, a kind of accurate thermal contraction detection device is provided for collagenous fibres class biomass material
And application process.
Background technology
With the rapid development of medical technology, organizational engineering and biomaterial also quick progress and development therewith.
According to clinical needs, in the market has worked out a variety of biomaterial class products with suitable for clinical patients, some high-molecular biologics
The physicochemical property of material product can not still fully meet the requirement of Clinical practice, therefore need to be through some either physically or chemically to material
Material is handled, as collagenous fiber material is being formed after product if it is highly susceptible to collagen in vivo without any crosslinking
The degraded of enzyme and do not have the effect of cell support arm.
In order to make the physics and chemistry of product, biological property index adapt to the demand of body, strengthen being crosslinked its product right and wrong for this
It is often important.Formation, which has, by taking biomembrane made of NTx fibrous material as an example, after collagen homogeneous is freeze-dried more causes
Close three dimensional pore structures, then after physical method is crosslinked, single removal of the collagen peptide interchain through some ions forms interchain
Mutual point combine（Crosslinking）, make biomembrane that there is preferable anti-degradation property.Collagenous fibres have the glue in peptide chain in itself
Original molecule because in thermal histories protein molecular can produce moment at a certain temperature and shrink phenomenon of rupture, now material is heated receives
The temperature of contracting is the heat shrink temperature of the material.Identical collagen-based materials its thermal contraction performance after distinct methods are crosslinked（Temperature）
It is different, and the thermal contraction performance of collagenous fibres class biomaterial can be carried out by precision equipment be adapted to, professional
Detection.The precision equipment complied fully with for collagenous fibres class biomaterial detection thermal contraction performance is there is no at present due to domestic,
Therefore, it is necessary to and provide and a kind of professional accurate be applied to sheet of the detection with three-dimensional structure, bulk, column, strip, pipe
The equipment of shape collagenous fibres class biomaterial thermal contraction performance.
A kind of operation principle of collagenous fibres class biomaterial thermal contraction performance detection device is to utilize testing sample albumen
Molecule it is heated reach certain temperature when molecule occur moment and shrink fracture, and this specific temperature can represent different condition
Crosslinking strengthen after, material reflects the power of the anti-degradation property of material to the difference of temperature shrinkage sensitivity indirectly.
Minimal shrink power is amplified to instrument board by this thermal contraction change by pulley transfer device by instrument indicator,
So as to obtain the temperature of testing sample heat shrinkable moment, the temperature shows testing sample anti-degraded journey in vivo indirectly
Degree.
The content of the invention
The invention provides a kind of detection device of thermal contraction performance reasonable in design and accurate, and it is applied to detection collagen
The molecular structure of fiber-like biomaterial it is heated reach moment after certain temperature shrink fracture when temperature, the equipment is small
Ingeniously, examined suitable for the sheet with three-dimensional structure, bulk, column, strip, tubulose collagenous fibres class biomaterial thermal contraction performance
Survey, there is the characteristics of high sensitivity, there is provided accurate heat shrink temperature value.
The present invention is achieved through the following technical solutions：
A kind of collagenous fibres class biomaterial thermal contraction performance detection device, main body are made of 304 steel, and long 30 ~ 90
Cm, wide 20 ~ 45 cm, high 30 ~ 50 cm, its structure include material preheater part, sample fixed part, mechanotransduction part with
And temperature indicating section.
Preferably, equipment regenerator section is made up of heating power supply, beaker, heating chassis, for testing sample device
Continuous heating is carried out, heating chassis diameter is 10 ~ 30 cm, and beaker diameter is supporting consistent with heating chassis diameter.
Preferably, the firm banking diameter that equipment sample fixed part is threaded structure is 2 ~ 6 cm.
Preferably, the clip of equipment sample fixed part is made of 304 steel, width is matched somebody with somebody with testing sample size
Set is consistent, is fixed on the beaker bottom with base after side clip clamping sample, after opposite side clip clamping sample with fine rule phase
Even.
Preferably, the beaker with base of equipment sample fixed part is positioned in heating dish, testing sample is fixed with
Beaker in add needed for liquid, liquid need to not excessively testing sample top completely, fluid temperature is in 20 ~ 70 DEG C in beaker
Between.
Preferably, in the heat indicator probe insertion liquid of equipment sample fixed part, it is attached to be positioned over testing sample
Closely, the temperature that sample in heating process shrinks moment is detected at any time.
Preferably, the pulley of equipment mechanotransduction part is made of polytetrafluoroethylene (PTFE), internal slot diameter size is 1 ~
2.5 cm, water jacket diameter are 1.5 ~ 3.0 cm, inside groove it is roomy it is small be 1 ~ 4 mm, a width of 3 ~ 7 mm of water jacket；Pulley surface
Smoothness ratings are better than No.2D.
Preferably, the threaded rod diameter of equipment mechanotransduction part is 1.5 ~ 4 cm, length is 15 ~ 25 cm,
For the level height of adjustable pulley, and then testing sample extended configuration is controlled, testing sample is kept nature extended position.
Preferably, the horizontal pole length of pulley of equipment mechanotransduction part is 10 ~ 25 cm.
Preferably, the fine rule of equipment mechanotransduction part using a diameter of 0.1 ~ 0.4 mm fishing line concatenation pointer and
Sample clip, fishing line material are superhigh molecular weight polyethylene fibers, and sample minimal shrink state is transferred into pointer by fine rule
It is amplified.
Preferably, the counterweight weight of device temperature indicating section is 0.5 ~ 2.5 g, the tail end of pointer, pointer are connected to
Length be defined by reaching scale dial scale.
Equipment application mode is：Sample shrinks situation and is transferred to pointer top by call wire and pulley, is amplified sight
Examine.In detection process, measuring samples are fixed in beaker using 2 geometrical clamps, pass through call wire and instrument indicator
It is connected, is slowly added into respective liquid into beaker, ensures liquid not excessively testing sample top, by threaded rod adjustable pulley,
Testing sample is set to keep nature extended position.Sample is heated by heater, observes instrument indicator top at any time
Fine motion situation, once fine motion occurs in pointer, that is, show that testing sample inner molecular structure shrinks reaction, while recording apparatus
The temperature that indicator fine motion instantaneous temperature meter is shown is sample heat shrink temperature.
Brief description of the drawings：
Fig. 1 is the structural representation of the present invention；
Fig. 2 is the top view of the present invention；
Embodiment
Such as Fig. 1, biomaterial thermal contraction detection means includes：1 heating dish, 2 thermometers, 3 beakers with base, 4
Frame, 5 clips, 6 fine rules, 7 pulleys, 8 roller arms, 9 threaded rods, 10 instrument indicators, 11 counterweights, 12 instrument.
Clip will be fixed to the beaker with base after sample clamping, fine rule one end is connected with clip, and the other end passes through pulley
It is connected with roller arm with instrument indicator, is positioned over after adding liquid into the beaker with base in heating dish, the spy of thermometer
Pin is positioned near sample by the support of support（Do not contact）For monitoring sample heating temperature in real time, adjust threaded rod and lead to
Crossing the weight of counterweight makes sample and counterweight reach poised state, and now the top of instrument indicator is shown necessarily on instrument board
Angle, open heating power supply and continuous heating is carried out to liquid in beaker.Dynamic of the record pointer in dial is examined, when
When pointer starts downwards fine motion, the numerical value of fine motion instantaneous temperature meter is recorded, this numerical value is the heat shrink temperature of biomaterial.
Embodiment：The thermal contraction performance detection of NTx endocranium repair materials
Use NTx endocranium repair materials thermal contraction of apparatus of the present invention detection specification for the mm of the mm of 5 mm × 10 × 50
Performance.
Take the mm of one piece of 5mm × 10mm × 50 NTx endocranium repair materials to be soaked in different liquids, one end by
Clip with fine rule fixes gripping, and the other end is fixed in the beaker with base by clip gripping, confirms that fine rule bypasses pulley,
And the other end is connected with pointer, pointer tail end hangs with the counterweight of constant weight, and 1 L purified waters are added into beaker, make liquid level complete
It is complete not have at the top of excessively NTx endocranium repair materials, by threaded rod adjustable pulley bar height, repair NTx endocranium
Multiple material is in nature extended configuration, record pointer position in dial, thermometer probe is positioned over into NTx endocranium
Near repair materials（Do not contact）.Heating power supply is opened, heating dish is carried out continuous heating to liquid in beaker.Examine note
Dynamic of the pointer in dial is recorded, when pointer starts fine motion downwards, records the numerical value of fine motion instantaneous temperature meter, the numerical value model
Enclose between 39 ~ 60 DEG C, this numerical value is the heat shrink temperature of NTx endocranium repair materials.
Claims (12)
1. a kind of collagenous fibres class biomaterial thermal contraction performance detection device, it is characterised in that it, which is applied to detection, has collagen
The material of the macromolecule protein structure of fiber its macromolecule protein structure after heat reaches certain temperature is shunk in moment
The performance of fracture, the device structure include material preheater part, sample fixed part, mechanotransduction part and temperature instruction unit
Point：1）Material preheater part forms heater by heating power supply, beaker, heating chassis, for being carried out to testing sample device
Continuous heating；2）Sample fixed part includes the sawtooth mouth sample for being fixed on beaker base that structure is threaded positioned at beaker bottom
Clip, the other end by the free same model sawtooth mouth sample with fine rule clip, for testing sample opposite side to be connected
It is fixed；3）Mechanotransduction part is connected the superhigh molecular weight polyethylene fibers fishing line of free fixing by one end, passes through height
Adjustable horizontal support and accurate conduction pulley composition, it is ensured that Level tune, the extended configuration for conducting sample, call wire it is remote
End is connected with instrument indicator, the micro- contraction triggered for conductive material by temperature change, so as to cause instrument indicator to exist
Observe the change on instrument board；4）Temperature indicating section is made up of the instrument indicator of instrument board and accurate activity, in beaker
Inside is equipped with certain volume liquid, and nature is kept under wet face state for guarantee testing sample and is heated evenly；Thermometer
Probe is positioned near testing sample, to ensure that test position temperature is consistent with sample heating temperature.
2. a kind of collagenous fibres class biomaterial thermal contraction performance detection device according to claim 1, its main body are adopted
It is made of 304 steel, long 30 ~ 90 cm, wide 20 ~ 45 cm, high 30 ~ 50 cm, mainly includes material preheater part, sample
Fixed part, mechanotransduction part and temperature indicating section.
3. a kind of collagenous fibres class biomaterial thermal contraction performance detection device according to claim 1, its feature exist
It is made up of in regenerator section heating power supply, beaker, heating chassis, for carrying out continuous heating to testing sample device, heats bottom
Disk diameter is 10 ~ 30 cm, and beaker diameter is supporting consistent with heating chassis diameter.
4. a kind of collagenous fibres class biomaterial thermal contraction performance detection device according to claim 1, its feature exist
The firm banking diameter that structure is threaded in sample fixed part is 2 ~ 6 cm.
5. a kind of collagenous fibres class biomaterial thermal contraction performance detection device according to claim 1, its feature exist
It is made in the clip of sample fixed part of 304 steel, width is supporting consistent with testing sample size, the clamping of side clip
The beaker bottom with base is fixed on after sample, is connected after opposite side clip clamping sample with fine rule.
6. a kind of collagenous fibres class biomaterial thermal contraction performance detection device according to claim 1, its feature exist
It is positioned in the beaker with base of sample fixed part in heating dish, is fixed with the beaker of testing sample liquid needed for adding
Body, liquid need to not excessively testing sample top completely, fluid temperature is between 20 ~ 70 DEG C in beaker.
7. a kind of collagenous fibres class biomaterial thermal contraction performance detection device according to claim 1, its feature exist
In the heat indicator probe insertion liquid of sample fixed part, it is positioned near testing sample, detects heating process at any time
Middle sample shrinks the temperature of moment.
8. a kind of collagenous fibres class biomaterial thermal contraction performance detection device according to claim 1, its feature exist
Pulley in mechanotransduction part is made of polytetrafluoroethylene (PTFE), and internal slot diameter size is 1 ~ 2.5 cm, and water jacket diameter is
1.5 ~ 3.0 cm, inside groove it is roomy it is small be 1 ~ 4 mm, a width of 3 ~ 7 mm of water jacket；Pulley surface smoothness ratings are better than No.2D.
9. a kind of collagenous fibres class biomaterial thermal contraction performance detection device according to claim 1, its feature exist
Threaded rod diameter in mechanotransduction part is 1.5 ~ 4 cm, and length is 15 ~ 25 cm, the level for adjustable pulley
Highly, and then testing sample extended configuration is controlled, testing sample is kept nature extended position.
10. a kind of collagenous fibres class biomaterial thermal contraction performance detection device according to claim 1, its feature exist
The horizontal pole length of pulley in mechanotransduction part is 10 ~ 25 cm.
11. a kind of collagenous fibres class biomaterial thermal contraction performance detection device according to claim 1, its feature exist
Fine rule in mechanotransduction part uses a diameter of 0.1 ~ 0.4 mm fishing line concatenation pointer and sample clip, and fishing line material is
Superhigh molecular weight polyethylene fibers, sample minimal shrink state is transferred to pointer by fine rule and is amplified.
12. a kind of collagenous fibres class biomaterial thermal contraction performance detection device according to claim 1, its feature exist
It is 0.5 ~ 2.5 g in the counterweight weight of temperature indicating section, is connected to the tail end of pointer, the length of pointer is to reach dial
Scale is defined.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711056629.8A CN107860788B (en) | 2017-11-01 | 2017-11-01 | Collagen fiber biomaterial heat shrinkage performance detection equipment and application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711056629.8A CN107860788B (en) | 2017-11-01 | 2017-11-01 | Collagen fiber biomaterial heat shrinkage performance detection equipment and application |
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| Publication Number | Publication Date |
|---|---|
| CN107860788A true CN107860788A (en) | 2018-03-30 |
| CN107860788B CN107860788B (en) | 2020-11-03 |
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| CN201711056629.8A Active CN107860788B (en) | 2017-11-01 | 2017-11-01 | Collagen fiber biomaterial heat shrinkage performance detection equipment and application |
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Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1299171A (en) * | 1968-10-12 | 1972-12-06 | Testrite Ltd | Apparatus for testing textile yarns or strips |
| CN1542438A (en) * | 2003-11-08 | 2004-11-03 | 陕西科技大学 | Precise determination analysis method and device for leather contraction temperature |
| CN2862023Y (en) * | 2006-01-05 | 2007-01-24 | 中国石化仪征化纤股份有限公司 | Heat shrinkage testing device for chemical fabrics filament |
| CN201007711Y (en) * | 2007-02-09 | 2008-01-16 | 陕西科技大学 | Leather contraction temperature measurer |
| CN201322730Y (en) * | 2008-12-26 | 2009-10-07 | 济南兰光机电技术有限公司 | Thermal shrinkage rate testing mechanism |
| CN204101490U (en) * | 2014-10-14 | 2015-01-14 | 浙江中天纺检测有限公司 | A kind of leather shrinking temperature tester |
| CN204664769U (en) * | 2015-04-14 | 2015-09-23 | 苏州大学 | Frog Skeletal Muscle Contraction analysis design mothod support |
| CN206330917U (en) * | 2016-12-27 | 2017-07-14 | 国家烟草质量监督检验中心 | Cigarette film shrink rate measurement apparatus and its measured material |
-
2017
- 2017-11-01 CN CN201711056629.8A patent/CN107860788B/en active Active
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1299171A (en) * | 1968-10-12 | 1972-12-06 | Testrite Ltd | Apparatus for testing textile yarns or strips |
| CN1542438A (en) * | 2003-11-08 | 2004-11-03 | 陕西科技大学 | Precise determination analysis method and device for leather contraction temperature |
| CN2862023Y (en) * | 2006-01-05 | 2007-01-24 | 中国石化仪征化纤股份有限公司 | Heat shrinkage testing device for chemical fabrics filament |
| CN201007711Y (en) * | 2007-02-09 | 2008-01-16 | 陕西科技大学 | Leather contraction temperature measurer |
| CN201322730Y (en) * | 2008-12-26 | 2009-10-07 | 济南兰光机电技术有限公司 | Thermal shrinkage rate testing mechanism |
| CN204101490U (en) * | 2014-10-14 | 2015-01-14 | 浙江中天纺检测有限公司 | A kind of leather shrinking temperature tester |
| CN204664769U (en) * | 2015-04-14 | 2015-09-23 | 苏州大学 | Frog Skeletal Muscle Contraction analysis design mothod support |
| CN206330917U (en) * | 2016-12-27 | 2017-07-14 | 国家烟草质量监督检验中心 | Cigarette film shrink rate measurement apparatus and its measured material |
Non-Patent Citations (5)
| Title |
|---|
| 何建新: "《新型纤维材料学》", 31 July 2014, 东华大学出版社 * |
| 宁铎 等: "新一代非接触式皮革收缩温度检测仪的开发与研制", 《中国皮革》 * |
| 李伟红 等: "《生理学实验教程》", 30 June 2010 * |
| 陈国华: "《水产养殖学专业专业基础课程实验》", 31 August 2012 * |
| 马令坤 等: "皮革收缩温度的检测与实现", 《中国皮革》 * |
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