CN107855081A - A kind of preparation method of microcapsules - Google Patents
A kind of preparation method of microcapsules Download PDFInfo
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- CN107855081A CN107855081A CN201711227854.3A CN201711227854A CN107855081A CN 107855081 A CN107855081 A CN 107855081A CN 201711227854 A CN201711227854 A CN 201711227854A CN 107855081 A CN107855081 A CN 107855081A
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- microcapsules
- preparation
- pbs
- colostrum
- add
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
- Manufacturing Of Micro-Capsules (AREA)
Abstract
A kind of preparation method of microcapsules, belongs to chemical synthesis preparation field.It is characterized in that：At ambient temperature, by PBS and CHCl3Add in flask, stir after PBS is completely dissolved, add H2Colostrum is made in O and emulsifying agent；Then colostrum is slowly poured into aqueous dispersant, emulsification at a high speed makes solvent C HCI3Slowly volatilization, as microcapsules separate out, after microcapsules are stable, washing separation, the microcapsules after separation are put into freeze drier and dry 24h, obtain white powdery solids；Dispersant includes PVAL and gelatin, and their proportioning is 2:8.Pass through the improvement to microcapsule preparation process and the adjustment wherein matched, so that prepared Microcapsules Size is larger, shape specification is uniform, and it is easy to be decomposed, preparation process is simple, easily operated, saves step and raw material, to a certain extent so that cost is reduced, microcapsule preparation method of the present invention has very big value in association area.
Description
Technical field
The invention belongs to chemical synthesis preparation field, more particularly to a kind of preparation method of microcapsules.
Background technology
With the rapid development of economy, the improvement of people's living standards, people will for living environment and the quality of material
More and more higher is sought, especially along with the aggravation of environment in recent years pollution and becoming increasingly conspicuous for food-safety problem, is led in correlation
Research in domain is with input also in cumulative year after year.It is further except being needed using the monitoring of raw material in field of food safety
Reinforcement outside, in the source of food manufacturing, the management and control in the planting process of raw material also can not be ignored.In traditional agricultural production
Used agricultural chemicals, can be because some chemical substances can not readily dissolve and remain in plant after pesticidal effects have been played
On, thus the residual of agricultural chemicals is caused, it is edible that certain injury can be caused to the body of people, therefore the preparation for agricultural chemicals is former
Reason and technique also need to be improved.
The content of the invention
A kind of present invention seek to address that above mentioned problem, there is provided preparation method of microcapsules.
A kind of preparation method of microcapsules, it is characterised in that：At ambient temperature, by 0.30g PBS and 10.0mL
CHCl3Add in flask, stir after PBS is completely dissolved, add 10.0mL H2Colostrum is made in O and emulsifying agent；Then by colostrum
Slowly it is poured into the 100.0mL aqueous solution that dispersant mass fraction is 2%, emulsifies at a high speed, make solvent C HCI3, slowly volatilization, with
Microcapsules precipitation, emulsion gradually becomes clarification after about 5~8h, after microcapsules are stable, washing separation, by the microcapsules after separation
It is put into freeze drier and dries 24h, obtains white powdery solids；Dispersant includes PVAL and gelatin, and their proportioning is
2:8。
The preparation method of a kind of microcapsules of the present invention, it is characterised in that the emulsifying agent includes sorbester p17 and tween
80, it is 7 that it, which is matched,:3.
The preparation method of a kind of microcapsules of the present invention, it is characterised in that the flask is three-necked flask.
The preparation method of a kind of microcapsules of the present invention, it is characterised in that the emulsification times are 1.5 hours.
A kind of preparation method of microcapsules of the present invention, match by the improvement to microcapsule preparation process and wherein
Adjustment so that prepared Microcapsules Size is larger, and shape specification is uniform, and is easy to be decomposed, and preparation process is simple, is easy to
Operation, saves step and raw material, to a certain extent cost is reduced, microcapsule preparation method of the present invention
There is very big value in association area.
Embodiment
A kind of preparation method of microcapsules, it is characterised in that：At ambient temperature, by 0.30g PBS and 10.0mL
CHCl3Add in flask, stir after PBS is completely dissolved, add 10.0mL H2Colostrum is made in O and emulsifying agent；Then by colostrum
Slowly it is poured into the 100.0mL aqueous solution that dispersant mass fraction is 2%, emulsifies at a high speed, make solvent C HCI3, slowly volatilization, with
Microcapsules precipitation, emulsion gradually becomes clarification after about 5~8h, after microcapsules are stable, washing separation, by the microcapsules after separation
It is put into freeze drier and dries 24h, obtains white powdery solids；Dispersant includes PVAL and gelatin, and their proportioning is
2:8。
A kind of preparation method of microcapsules of the present invention, the emulsifying agent include sorbester p17 and Tween 80, and it is matched
For 7:3.The flask is three-necked flask.The emulsification times are 1.5 hours.When being individually added into PVAL, the microcapsules of preparation
Coexisted for hollow microcapsules and solid microcapsules, hollow microcapsules are relatively regular, solid microcapsules part deformity, particle diameter distribution compared with
It is wide；When being individually added into gelatin, obtained microcapsules shape is preferable, but solid microcapsules are more, and particle diameter is larger, dispersiveness compared with
Difference, mutually bond between microcapsules；When the mass ratio of PVAL and gelatin is 1：When 9, the hollow microcapsules dispersiveness of preparation is poor,
There is part lopsided, reunite, caking；When the mass ratio of PVAL and gelatin is 2：When 8, the hollow microcapsules of preparation are relatively regular, cyst wall
More thin and smooth, preferably, particle diameter is smaller for dispersiveness.When the mass ratio of the legendary small dragon with horns of P VI and gelatin is 2：When 8, prepared by solvent evaporation method
Surface of microcapsule is smooth, after the microcapsules vacuum of preparation is fully dried, is handled by liquid nitrogen brittle failure, it has been observed that microcapsules
Depression is dry flat, and the microcapsules for showing to prepare are hollow.Therefore, when the mass ratio of dispersant PVAL and gelatin is 2：When 8, solvent is used
Microcapsules shape prepared by volatility process is relatively regular, and preferably, particle diameter is smaller for dispersiveness.When dispersant PVAL and gelatin mass ratio are
2：When 8, using Tween 80 as single emulsifier, the hollow microcapsules of preparation are relatively regular, and cyst wall is more thin and smooth, capsule when drying separation
Wall is easily destroyed；Using sorbester p17 as single emulsifier, the hollow microcapsules cyst wall of preparation is relatively thin, has part lopsided, particle diameter is larger.
The mass ratio of dispersant PVAL and gelatin is 2：8, the volume ratio of emulsifier tween 80 and sorbester p17 is 7：3, the micro- glue of PBS of preparation
Not only shape is preferable for capsule, and particle diameter is more homogeneous, and distribution is narrower.
Claims (4)
- A kind of 1. preparation method of microcapsules, it is characterised in that：At ambient temperature, by 0.30g PBS and 10.0mL CHCl3Add Enter in flask, stir after PBS is completely dissolved, add 10.0mL H2Colostrum is made in O and emulsifying agent；Then colostrum is slowly inclined Enter in the 100.0mL aqueous solution that dispersant mass fraction is 2%, emulsify at a high speed, make solvent C HCI3, slowly volatilization, with micro- glue Capsule separates out, and emulsion gradually becomes clarification after about 5~8h, after microcapsules are stable, washing separation, the microcapsules after separation is put into cold 24h is dried in lyophilizer, obtains white powdery solids；Dispersant includes PVAL and gelatin, and their proportioning is 2:8.
- A kind of 2. preparation method of microcapsules as claimed in claim 1, it is characterised in that the emulsifying agent include sorbester p17 and Tween 80, it is 7 that it, which is matched,:3.
- 3. a kind of preparation method of microcapsules as claimed in claim 1, it is characterised in that the flask is three-necked flask.
- 4. a kind of preparation method of microcapsules as claimed in claim 1, it is characterised in that the emulsification times are 1.5 hours.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711227854.3A CN107855081A (en) | 2017-11-29 | 2017-11-29 | A kind of preparation method of microcapsules |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711227854.3A CN107855081A (en) | 2017-11-29 | 2017-11-29 | A kind of preparation method of microcapsules |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107855081A true CN107855081A (en) | 2018-03-30 |
Family
ID=61704538
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711227854.3A Withdrawn CN107855081A (en) | 2017-11-29 | 2017-11-29 | A kind of preparation method of microcapsules |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107855081A (en) |
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2017
- 2017-11-29 CN CN201711227854.3A patent/CN107855081A/en not_active Withdrawn
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20180330 |
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| WW01 | Invention patent application withdrawn after publication |