CN107854728A - Porous bone renovating material and preparation method - Google Patents

Porous bone renovating material and preparation method Download PDF

Info

Publication number
CN107854728A
CN107854728A CN201711135342.4A CN201711135342A CN107854728A CN 107854728 A CN107854728 A CN 107854728A CN 201711135342 A CN201711135342 A CN 201711135342A CN 107854728 A CN107854728 A CN 107854728A
Authority
CN
China
Prior art keywords
renovating material
porous bone
bone renovating
bone
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201711135342.4A
Other languages
Chinese (zh)
Inventor
邓怡
伍彦霖
谢璐
谢克难
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sichuan University
Original Assignee
Sichuan University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sichuan University filed Critical Sichuan University
Priority to CN201711135342.4A priority Critical patent/CN107854728A/en
Publication of CN107854728A publication Critical patent/CN107854728A/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/12—Phosphorus-containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
    • A61L27/3645—Connective tissue
    • A61L27/365—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Botany (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Inorganic Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Materials For Medical Uses (AREA)

Abstract

The invention belongs to a kind of porous bone renovating material in field of medical materials and preparation method, the composition of porous bone renovating material are as follows by weight percentage：β tricalcium phosphates 30% ~ 70%, people's dentine 30% ~ 70%.Preparation method is as follows：By weight percentage, negated crystal phosphoric acid DFP powder 30% ~ 70%, people's dentine powder 30% ~ 70%, it is well mixed, counted using two kinds of powder gross weights as 100%, add 10 ~ 20% perforating agents and 0.5 ~ 1% bonding agent, remix uniformly, add in mould, it is compressing, porous bone renovating material is made after high temperature sintering.Instant invention overcomes autologous bone source in existing bone impairment renovation material to be limited, also there is the defects of deficiency in mechanical performance, biocompatibility, self-bone grafting ability etc. for artificial synthesized bone material, there is provided porous bone renovating material there is excellent mechanical performance, good biocompatibility, preferable self-bone grafting ability.

Description

Porous bone renovating material and preparation method
Technical field
The invention belongs to field of medical materials, and in particular to a kind of porous bone renovating material and preparation method.
Background technology
Oromaxillo-facial region bone structure is the important foundation of supporting surface type, occur the wound in oromaxillo-facial region, infection, Tumour etc. often triggers the big defect of patient's Maxillary region bone tissue or missing, and great pain is brought for patient, meanwhile, how preferably Ground carries out emphasis urgently to be resolved hurrily in reparation and Oral and Maxillofacial Surgery to patient face type and bone tissue defect and difficult point is asked Topic.Bone collection is currently one of main method for treating Cranial defect, and autologous bone transplanting is clinical conventional and higher success rate biography System bone defect healing method, but because autologous bone source itself is limited, it is necessary to open up the second field of operation, wound is big, not only increases The pain of patient increases the risk of generation postoperative infection again, and the use of this method is by a definite limitation.Artificial synthesized aggregate Material is clinically commonly used in bone defect healing, and the research of association area is the focus that scholars follow the trail of always.But existing people Also there is very big deficiency in mechanical performance, biocompatibility, self-bone grafting ability etc. for work synthesis bone material.
The content of the invention
The invention aims to overcome autologous bone source in existing bone impairment renovation material to be limited, artificial synthesized aggregate In mechanical performance, biocompatibility, self-bone grafting ability etc. also there is the defects of deficiency, provide one kind for people has material Excellent mechanical performance, good biocompatibility, the porous bone renovating material of preferable self-bone grafting ability and preparation method.
The purpose of the present invention is realized by following proposal.
The porous bone renovating material of the present invention, it is characterised in that the composition by weight hundred of the porous bone renovating material Divide as follows than counting：
Bata-tricalcium phosphate 30% ~ 70%, people's dentine 30% ~ 70%.
The preparation method of the porous bone renovating material of the present invention is as follows：
By weight percentage, negated crystal phosphoric acid DFP（ACP）Powder 30% ~ 70%, people's dentine powder 30% ~ 70%, by two Kind powder is well mixed, and is counted using two kinds of powder gross weights as 100%, adds the perforating agent of percentage by weight 10 ~ 20% and 0.5 ~ 1% bonding Agent, remix uniformly, add in mould, it is compressing, porous bone renovating material is made after high temperature sintering.
In such scheme, the perforating agent is stearic acid, polyethylene glycol or polyvinylpyrrolidone.
In such scheme, the bonding agent is polyvinyl alcohol, carboxymethyl cellulose or polyvinyl butyral resin.
In such scheme, the concrete technology of the high temperature sintering is：
The model suppressed is heated to 300 DEG C and is incubated 0.5h, then is warming up to 900 DEG C, is incubated 0.5h, then be warming up to 1180 DEG C And it is incubated 2h.
Bata-tricalcium phosphate in the present invention is generated by noncrystal tricalcium phosphate after high temperature sintering, perforating agent and bonding agent Gasify at high temperature, so as to obtain porous bone renovating material.
Bata-tricalcium phosphate（β-Ca3(PO4)2）It is a kind of good biocompatibility, the bioceramic material of biodegradable in vivo Material, has good osteoconductive, bioactivity and biocompatibility.Tooth has similar chemical composition and power to bone tissue Learn property, be by the composite of inorganic, organic material combination, be a kind of biological mixed crystal, its main thing phase composition be containing The carbonate-hydroxylapatite of lot of trace composition, other inorganic constituents also include CO3 2-、Mg2+、Na+、F-Deng element.Clinically because A large amount of teeth that impaction, more lifes, correction needs, wound etc. are pulled out are discarded as medical waste, people's tooth this it is valuable can not be again Raw human organ resource is greatly wasted.People's dentine and bata-tricalcium phosphate are mixed and made into porous Bone Defect Repari by the present invention Material, not only tooth is re-used, assign its new application value, be more beneficial for composite and form bone with bone tissue Property combine, good biocompatibility, be more conducive to the reparation of Cranial defect.Bata-tricalcium phosphate and people's dentine are matched somebody with somebody by a certain percentage To put, the biodegradation rate of controllable bata-tricalcium phosphate/dentine compound is better than single dentine on controlled degradation, Can preferably repairing bone defect.Three-dimensional porous structure is more stronger than the self-bone grafting effect of compact texture, is more beneficial for Bone Defect Repari.And And preparation method provided by the invention is simple, cost is cheap, the product good mechanical performance of preparation.
In summary, instant invention overcomes autologous bone source in existing bone impairment renovation material to be limited, artificial synthesized aggregate Material in mechanical performance, biocompatibility, self-bone grafting ability etc., also there is the defects of deficiency, there is provided porous Bone Defect Repari Material has excellent mechanical performance, good biocompatibility, preferable self-bone grafting ability.The porous bone renovating material system of offer Preparation Method is simple, and cost is cheap.
Embodiment
The invention is further illustrated by the following examples, and the present invention is not limited only to the embodiment.
Embodiment one
The porous bone renovating material composition of this example is as follows：
Bata-tricalcium phosphate 30%, people's dentine 70%.
The porous bone renovating material preparation method of this example is：
By weight percentage, negated crystal phosphoric acid DFP（ACP）Powder 30%, people's dentine powder 70%, two kinds of powders are mixed Close uniformly, counted using two kinds of powder gross weights as 100%, add the perforating agent of percentage by weight 20% and 0.5% bonding agent, remix uniformly, Add in mould, it is compressing, porous bone renovating material is made after high temperature sintering.
Perforating agent is stearic acid.
Bonding agent is polyvinyl alcohol, is made into aqueous solution use.
The concrete technology of high temperature sintering is：
The model suppressed is heated to 300 DEG C and is incubated 0.5h, then is warming up to 900 DEG C, is incubated 0.5h, then be warming up to 1180 DEG C And it is incubated 2h.
Noncrystal tricalcium phosphate（ACP）Powder is prepared as follows：
By Ca (NO3)2(NH4)2HPO4It is 1.5 according to Ca/P ratios, is each configured to 0.9 mol/L and 0.6mol/L solution, At room temperature by (NH4)2HPO4Solution is slowly dropped to Ca (NO3)2In solution, and pH value is adjusted with concentrated ammonia liquor, make reaction system PH value is controlled between 8 ~ 10.5, and constantly stirring reaction 5h, is aged 24h, and product is through filtering, deionized water is washed, alcohol is washed, in Dried for standby at 80 DEG C.
People's dentine powder is prepared as follows：
The periodontium of people's Isolated Tooth is wiped off completely, using dental high-speed cell phone, enamel, dentale are removed along contour Matter, while remove pulp tissue and reactive dentine using mechanical means；By income earner's dentine immersion in deionized water 3 Hour, and cleaned per hour using supersonic wave cleaning machine 30 minutes, deionized water is changed once per hour；Afterwards will with pulverizer People's dentine after cleaning crushes.
Porous bone renovating material prepared by this example is through infrared（IR）Spectrum analysis, in 609 cm-1、550 cm-1、1041 cm-1、1121 cm-1There is PO at place4 3-Absworption peak.In 1432cm-1The absworption peak at place and from 2800 cm-1To 3472 cm-1It Between absworption peak be hydroxyl absorption peak.X-ray diffraction（XRD）Spectrogram shows, in 2 θ=31 °, 2 θ=27 °, and 2 θ=34 °, 2 θ= 32 °, nearby there is its characteristic peak 2 θ=46 °, 2 θ=52 °.Infrared and X-ray diffraction analysis result shows：This example is prepared more Permeability bone renovating material is the mixture of bata-tricalcium phosphate and people's dentine.
Porous bone renovating material maximum load prepared by this example is 68.44N, and maximum load is deformed into 0.23 mm, elasticity Modulus is 879.05 N/mm2。
Embodiment two
The porous bone renovating material composition of this example is as follows：Bata-tricalcium phosphate 50%, people's dentine 50%.
The porous bone renovating material preparation method of this example is：
By weight percentage, negated crystal phosphoric acid DFP（ACP）Powder 50%, people's dentine powder 50%, two kinds of powders are mixed Close uniformly, counted using two kinds of powder gross weights as 100%, add the perforating agent of percentage by weight 15% and 0.8% bonding agent, remix uniformly, Add in mould, it is compressing, porous bone renovating material is made after high temperature sintering.
Perforating agent is polyethylene glycol.
Bonding agent is carboxymethyl cellulose, is made into aqueous solution use.
Porous bone renovating material maximum load prepared by this example is 70.25N, and maximum load is deformed into 0.25 mm, elasticity Modulus is 986.08 N/mm2。
Remaining is the same as embodiment one.
Embodiment three
The porous bone renovating material composition of this example is as follows：Bata-tricalcium phosphate 70%, people's dentine 30%.
The porous bone renovating material preparation method of this example is：
By weight percentage, negated crystal phosphoric acid DFP（ACP）Powder 70%, people's dentine powder 30%, two kinds of powders are mixed Close uniformly, counted using two kinds of powder gross weights as 100%, add the perforating agent of percentage by weight 10% and 1% bonding agent, remix uniformly, add Enter in mould, it is compressing, porous bone renovating material is made after high temperature sintering.
Perforating agent is polyvinylpyrrolidone.
Bonding agent is polyvinyl butyral resin, is made into aqueous solution use.
Porous bone renovating material maximum load prepared by this example is 83.85N, and maximum load is deformed into 0.25 mm, elasticity Modulus is 801.71 N/mm2。
Remaining is the same as embodiment one.

Claims (5)

1. a kind of porous bone renovating material, it is characterised in that the composition of the porous bone renovating material is by weight percentage It is as follows：
Bata-tricalcium phosphate 30% ~ 70%, people's dentine 30% ~ 70%.
2. a kind of preparation method of porous bone renovating material, it is characterised in that technique is as follows：
By weight percentage, negated crystal phosphoric acid DFP powder 30% ~ 70%, people's dentine powder 30% ~ 70%, by two kinds of powders It is well mixed, counted using two kinds of powder gross weights as 100%, add the perforating agent of percentage by weight 10 ~ 20% and 0.5 ~ 1% bonding agent, then mix Close uniform, compressing in addition mould, the obtained porous bone renovating material after high temperature sintering.
3. the preparation method of porous bone renovating material according to claim 2, it is characterised in that the perforating agent is hard Resin acid, polyethylene glycol or polyvinylpyrrolidone.
4. the preparation method of porous bone renovating material according to claim 2, it is characterised in that the bonding agent is poly- Vinyl alcohol, carboxymethyl cellulose or polyvinyl butyral resin.
5. the preparation method of porous bone renovating material according to claim 2, it is characterised in that the high temperature sintering Concrete technology is：
The model suppressed is heated to 300 DEG C and is incubated 0.5h, then is warming up to 900 DEG C, is incubated 0.5h, then be warming up to 1180 DEG C And it is incubated 2h.
CN201711135342.4A 2017-11-16 2017-11-16 Porous bone renovating material and preparation method Pending CN107854728A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201711135342.4A CN107854728A (en) 2017-11-16 2017-11-16 Porous bone renovating material and preparation method

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201711135342.4A CN107854728A (en) 2017-11-16 2017-11-16 Porous bone renovating material and preparation method

Publications (1)

Publication Number Publication Date
CN107854728A true CN107854728A (en) 2018-03-30

Family

ID=61701784

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201711135342.4A Pending CN107854728A (en) 2017-11-16 2017-11-16 Porous bone renovating material and preparation method

Country Status (1)

Country Link
CN (1) CN107854728A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114984308A (en) * 2022-06-28 2022-09-02 奥精医疗科技股份有限公司 Cleft lip and palate repair material and preparation method thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5626861A (en) * 1994-04-01 1997-05-06 Massachusetts Institute Of Technology Polymeric-hydroxyapatite bone composite
JP2006006546A (en) * 2004-06-24 2006-01-12 Olympus Corp Bone prosthetic material, bone prosthesis and method of manufacturing the same
CN102138865A (en) * 2011-03-31 2011-08-03 四川大学 Pulp capping agent with bioactivity and preparation method thereof
CN104994806A (en) * 2013-01-15 2015-10-21 科麦塔生物股份有限公司 Apparatus and method for producing a dental bone graft
CN106823001A (en) * 2017-04-12 2017-06-13 吉林大学 A kind of biologic bracket material, preparation method and applications for dental root regeneration

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5626861A (en) * 1994-04-01 1997-05-06 Massachusetts Institute Of Technology Polymeric-hydroxyapatite bone composite
JP2006006546A (en) * 2004-06-24 2006-01-12 Olympus Corp Bone prosthetic material, bone prosthesis and method of manufacturing the same
CN102138865A (en) * 2011-03-31 2011-08-03 四川大学 Pulp capping agent with bioactivity and preparation method thereof
CN104994806A (en) * 2013-01-15 2015-10-21 科麦塔生物股份有限公司 Apparatus and method for producing a dental bone graft
CN106823001A (en) * 2017-04-12 2017-06-13 吉林大学 A kind of biologic bracket material, preparation method and applications for dental root regeneration

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114984308A (en) * 2022-06-28 2022-09-02 奥精医疗科技股份有限公司 Cleft lip and palate repair material and preparation method thereof
CN114984308B (en) * 2022-06-28 2023-07-28 奥精医疗科技股份有限公司 Cleft lip and palate repairing material and preparation method thereof

Similar Documents

Publication Publication Date Title
US5542973A (en) Calcium phosphate hydroxyapatite precursor and methods for making and using the same
US4917702A (en) Bone replacement material on the basis of carbonate and alkali containing calciumphosphate apatites
CN104056305B (en) A kind of calcium orthophosphate base is combined self-curing bone renovating material and preparation method thereof
EP2252338B1 (en) Bone graft material and uses thereof
CN104030718B (en) Porous calcium carbonate ceramic of a kind of trace elements that adulterates and its preparation method and application
CN100536936C (en) New-type of inorganic bone grafting material and its preparation and use
EP0721320A1 (en) Self-setting calcium phosphate cements and methods for preparing and using them
CN105084336A (en) Two-phase calcium phosphate material, preparation method thereof, and two-phase calcium phosphate artificial bone ceramic
CN102424581A (en) Hydroxyapatite bioceramic for bone connection and bone repair and preparation method thereof
CN104906635A (en) Poly(ether-ether-ketone)/nano hydroxyapatite dental implant and manufacturing method thereof
CN105748510A (en) Fluorine controlled-release calcium phosphate bioactive material and preparation method thereof
CN107854728A (en) Porous bone renovating material and preparation method
CN105999418A (en) Injectable bioactive bone cement material and preparation method thereof
Zhu et al. Cemented injectable multi-phased porous bone grafts for the treatment of femoral head necrosis
JP2007501054A (en) Calcium phosphate cement medical implant manufacturing method and medical implant
CN106924090B (en) A kind of preparation and application of the immobilized lysozyme toothpaste of multistage hole bioactive glass
US9090471B2 (en) Method for producing fluorapatite and its application
CN111921014B (en) Rehmannia polysaccharide/heterogenous calcined bone composite bone repair material
JPH09103478A (en) Hardenable material for medical or dental purpose
RU2624873C1 (en) Method for osteoplastic material obtaining
JPH0575427B2 (en)
JP2544075B2 (en) Method for producing cured body for medical and dental treatment
JPS63294864A (en) Preparation of artificial bone material
CN103785062A (en) Bone repair material of coating hydroxyapatite and preparation method of bone repair material
CN116099052A (en) Preparation method of high-activity bone repair stent material

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication
RJ01 Rejection of invention patent application after publication

Application publication date: 20180330