CN107854728A - Porous bone renovating material and preparation method - Google Patents
Porous bone renovating material and preparation method Download PDFInfo
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- 210000000988 bone and bone Anatomy 0.000 title claims abstract description 60
- 239000000463 material Substances 0.000 title claims abstract description 44
- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- 239000000843 powder Substances 0.000 claims abstract description 25
- 210000004268 dentin Anatomy 0.000 claims abstract description 21
- 239000000203 mixture Substances 0.000 claims abstract description 15
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 12
- 238000005245 sintering Methods 0.000 claims abstract description 10
- 239000001506 calcium phosphate Substances 0.000 claims abstract description 8
- 229940078499 tricalcium phosphate Drugs 0.000 claims abstract description 8
- 229910000391 tricalcium phosphate Inorganic materials 0.000 claims abstract description 8
- 238000000034 method Methods 0.000 claims description 7
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 3
- 239000002202 Polyethylene glycol Substances 0.000 claims description 3
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 3
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 3
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 3
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 3
- 229920002037 poly(vinyl butyral) polymer Polymers 0.000 claims description 3
- 229920001223 polyethylene glycol Polymers 0.000 claims description 3
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 3
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 3
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 3
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 3
- 239000013078 crystal Substances 0.000 claims description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims 2
- 239000007767 bonding agent Substances 0.000 claims 2
- 238000010792 warming Methods 0.000 claims 2
- RSWGJHLUYNHPMX-UHFFFAOYSA-N 1,4a-dimethyl-7-propan-2-yl-2,3,4,4b,5,6,10,10a-octahydrophenanthrene-1-carboxylic acid Chemical compound C12CCC(C(C)C)=CC2=CCC2C1(C)CCCC2(C)C(O)=O RSWGJHLUYNHPMX-UHFFFAOYSA-N 0.000 claims 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims 1
- 229940068984 polyvinyl alcohol Drugs 0.000 claims 1
- 235000019422 polyvinyl alcohol Nutrition 0.000 claims 1
- 229920005989 resin Polymers 0.000 claims 1
- 239000011347 resin Substances 0.000 claims 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 abstract description 18
- 230000007547 defect Effects 0.000 abstract description 12
- 239000000853 adhesive Substances 0.000 abstract description 9
- 230000001070 adhesive effect Effects 0.000 abstract description 9
- 230000002138 osteoinductive effect Effects 0.000 abstract description 8
- 235000019731 tricalcium phosphate Nutrition 0.000 abstract description 7
- 239000012567 medical material Substances 0.000 abstract description 2
- 238000000465 moulding Methods 0.000 abstract description 2
- 238000010521 absorption reaction Methods 0.000 description 4
- 239000011148 porous material Substances 0.000 description 4
- 239000007864 aqueous solution Substances 0.000 description 3
- 239000002131 composite material Substances 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 235000021355 Stearic acid Nutrition 0.000 description 2
- 238000002441 X-ray diffraction Methods 0.000 description 2
- 239000008367 deionised water Substances 0.000 description 2
- 229910021641 deionized water Inorganic materials 0.000 description 2
- 230000001815 facial effect Effects 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical group CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 2
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 2
- 239000008117 stearic acid Substances 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 238000002054 transplantation Methods 0.000 description 2
- 230000008733 trauma Effects 0.000 description 2
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 235000011114 ammonium hydroxide Nutrition 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 239000003462 bioceramic Substances 0.000 description 1
- 238000006065 biodegradation reaction Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 210000003298 dental enamel Anatomy 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 239000011147 inorganic material Substances 0.000 description 1
- 239000002906 medical waste Substances 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000011368 organic material Substances 0.000 description 1
- 238000010883 osseointegration Methods 0.000 description 1
- 230000003239 periodontal effect Effects 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000010183 spectrum analysis Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/12—Phosphorus-containing materials, e.g. apatite
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
- A61L27/3645—Connective tissue
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
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- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
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Abstract
本发明属于医用材料领域内的一种多孔性骨修复材料及制备方法，多孔性骨修复材料的组成按重量百分比计如下：β‑磷酸三钙30%~70%，人牙本质30%~70%。制备方法如下：按重量百分比计，取非晶体磷酸三钙粉体30%~70%，人牙本质粉体30%~70%，混合均匀，以两种粉体总重为100%计，加入10~20%制孔剂和0.5~1%粘接剂，再混合均匀，加入模具中，压制成型，经过高温烧结后制得多孔性骨修复材料。本发明克服了现有骨缺损修复材料中自体骨来源受限，人工合成骨材料在机械性能、生物相容性、骨诱导能力等方面还存在着不足的缺陷，提供的多孔性骨修复材料具有优良的机械性能、生物相容性好、较好的骨诱导能力。The invention belongs to a porous bone repair material and a preparation method in the field of medical materials. The composition of the porous bone repair material is as follows by weight percentage: β-tricalcium phosphate 30%~70%, human dentin 30%~70% %. The preparation method is as follows: by weight percentage, take 30%~70% of amorphous tricalcium phosphate powder and 30%~70% of human dentin powder, mix evenly, and take the total weight of the two powders as 100%, add 10~20% pore-forming agent and 0.5~1% adhesive, and then mixed evenly, put into the mold, press molding, after high-temperature sintering to make a porous bone repair material. The present invention overcomes the limitation of autologous bone sources in the existing bone defect repair materials, and the insufficient defects of artificial synthetic bone materials in terms of mechanical properties, biocompatibility, osteoinductive ability, etc., and provides porous bone repair materials with Excellent mechanical properties, good biocompatibility, good osteoinductive ability.
Description
技术领域technical field
本发明属于医用材料领域，具体涉及一种多孔性骨修复材料及制备方法。The invention belongs to the field of medical materials, and in particular relates to a porous bone repair material and a preparation method.
背景技术Background technique
口腔颌面部骨组织结构是支撑面型的重要基础，发生在口腔颌面部的外伤、感染、肿瘤等往往引发患者颌面部骨组织大缺损或缺失，为患者带来极大的痛苦，同时，如何较好地对患者面型及骨组织缺损进行修复也是口腔颌面外科手术中亟待解决的重点和难点问题。骨移植目前是治疗骨缺损的主要方法之一，自体骨移植是临床常用且成功率较高的传统骨缺损修复方法，但由于自体骨本身来源受限，需要开辟第二手术区，创伤大，不仅增加了患者的痛苦又使发生手术感染的风险增加，该方法的使用受到一定限制。人工合成骨材料在骨缺损修复临床上普遍应用，相关领域的研究是学者们一直追踪的热点。但现有的人工合成骨材料在机械性能、生物相容性、骨诱导能力等方面还存在着很大的不足。Oral and maxillofacial bone tissue structure is an important basis for supporting the facial shape. Trauma, infection, tumor, etc. that occur in the oral and maxillofacial area often cause large defects or loss of maxillofacial bone tissue, which brings great pain to patients. At the same time, how to better repair the patient's facial shape and bone tissue defects is also an important and difficult problem to be solved in oral and maxillofacial surgery. Bone transplantation is currently one of the main methods for treating bone defects. Autologous bone transplantation is a traditional bone defect repair method that is commonly used in clinical practice and has a high success rate. It not only increases the pain of the patient but also increases the risk of surgical infection, so the use of this method is limited. Synthetic bone materials are commonly used clinically in the repair of bone defects, and research in related fields has been a hotspot that scholars have been following. However, the existing synthetic bone materials still have great deficiencies in terms of mechanical properties, biocompatibility, and osteoinductive ability.
发明内容Contents of the invention
本发明的目的是为了克服现有骨缺损修复材料中自体骨来源受限，人工合成骨材料在机械性能、生物相容性、骨诱导能力等方面还存在着不足的缺陷，为人们提供一种具有优良的机械性能、生物相容性好、较好的骨诱导能力的多孔性骨修复材料及制备方法。The purpose of the present invention is to overcome the limitations of autologous bone sources in the existing bone defect repair materials, and the insufficient defects of artificial synthetic bone materials in terms of mechanical properties, biocompatibility, osteoinductive ability, etc., to provide people with a A porous bone repair material with excellent mechanical properties, good biocompatibility, and good osteoinductive ability and a preparation method thereof.
本发明的目的是通过下述方案来实现的。The purpose of the present invention is achieved by the following scheme.
本发明的多孔性骨修复材料，其特征在于所述多孔性骨修复材料的组成按重量百分比计如下：The porous bone repair material of the present invention is characterized in that the composition of the porous bone repair material is as follows by weight percentage:
β-磷酸三钙30%~70%，人牙本质30%~70%。β-tricalcium phosphate 30%~70%, human dentin 30%~70%.
本发明的多孔性骨修复材料的制备方法如下：The preparation method of the porous bone repair material of the present invention is as follows:
按重量百分比计，取非晶体磷酸三钙（ACP）粉体30%~70%，人牙本质粉体30%~70%，将两种粉体混合均匀，以两种粉体总重为100%计，加入重量百分比10~20%制孔剂和0.5~1%粘接剂，再混合均匀，加入模具中，压制成型，经过高温烧结后制得多孔性骨修复材料。In terms of weight percentage, take 30%~70% of amorphous tricalcium phosphate (ACP) powder and 30%~70% of human dentin powder, mix the two powders evenly, and take the total weight of the two powders as 100% %, add 10-20% pore-forming agent and 0.5-1% adhesive by weight, mix evenly, add to the mold, press and form, and make porous bone repair material after high-temperature sintering.
上述方案中，所述制孔剂为硬脂酸、聚乙二醇或聚乙烯吡咯烷酮。In the above scheme, the pore forming agent is stearic acid, polyethylene glycol or polyvinylpyrrolidone.
上述方案中，所述粘接剂为聚乙烯醇、羧甲基纤维素或聚乙烯醇缩丁醛。In the above scheme, the adhesive is polyvinyl alcohol, carboxymethyl cellulose or polyvinyl butyral.
上述方案中，所述高温烧结的具体工艺为：In the above scheme, the specific process of the high-temperature sintering is:
将压制好的模型加热到300℃并保温0.5h，再升温至900℃，孵育0.5h，再升温至1180℃并保温2h。Heat the pressed model to 300°C and keep it warm for 0.5h, then raise the temperature to 900°C, incubate for 0.5h, then raise the temperature to 1180°C and keep it warm for 2h.
本发明中的β-磷酸三钙系由非晶体磷酸三钙经高温烧结后生成，制孔剂和粘接剂在高温下气化，从而得到多孔性骨修复材料。The β-tricalcium phosphate in the present invention is produced by high-temperature sintering of amorphous tricalcium phosphate, and the pore-forming agent and adhesive are vaporized at high temperature, thereby obtaining a porous bone repair material.
β-磷酸三钙（β-Ca3(PO4)2）是一种生物相容性好，在体内可生物降解的生物陶瓷材料，具有良好的骨传导性，生物活性和生物相容性。牙齿与骨组织具有相似的化学组成和力学性质，均是由无机、有机材料结合的复合材料，是一种生物混晶，其主要物相组成为含有多种微量成分的碳羟磷灰石，其他无机成分还包括 CO3 2-、Mg2+、Na+、F-等元素。临床上因为阻生、多生、正畸需要、外伤等拔除的大量牙齿作为医疗垃圾废弃，人牙这一宝贵的不可再生的人体器官资源被极大地浪费。本发明将人牙本质与β-磷酸三钙混合制成多孔性骨修复材料，不仅将牙齿重新利用起来，赋予其新的应用价值，更有利于复合材料与骨组织形成骨性结合，生物相容性好，更有助于骨缺损的修复。将β-磷酸三钙与人牙本质按一定比例配置，可调控β-磷酸三钙/牙本质复合物的生物降解速率，在可控降解性上比单一牙本质好，能更好地修复骨缺损。立体多孔结构比致密结构的骨诱导效应更强，更有利于骨修复。而且，本发明提供的制备方法简单，成本低廉，制备的产品机械性能优良。β-tricalcium phosphate (β-Ca 3 (PO 4 ) 2 ) is a kind of biocompatibility and biodegradable bioceramic material in vivo, which has good osteoconductivity, bioactivity and biocompatibility. Teeth and bone tissue have similar chemical composition and mechanical properties. They are both composite materials combined with inorganic and organic materials. They are biological mixed crystals. Other inorganic components also include CO 3 2- , Mg 2+ , Na + , F - and other elements. Clinically, a large number of teeth extracted due to impacted, supernumerary, orthodontic needs, trauma, etc. are discarded as medical waste, and human teeth, a precious non-renewable human organ resource, are greatly wasted. The present invention mixes human dentin and β-tricalcium phosphate to make a porous bone repair material, which not only reuses the teeth, endows it with new application value, but also facilitates the formation of osseointegration between the composite material and bone tissue, and biophase Good capacity, more conducive to the repair of bone defects. Combining β-tricalcium phosphate and human dentin in a certain ratio can regulate the biodegradation rate of β-tricalcium phosphate/dentin composite, which is better than single dentin in controllable degradation and can better repair bone defect. The three-dimensional porous structure has a stronger osteoinductive effect than the dense structure, and is more conducive to bone repair. Moreover, the preparation method provided by the invention is simple and low in cost, and the prepared product has excellent mechanical properties.
综上所述，本发明克服了现有骨缺损修复材料中自体骨来源受限，人工合成骨材料在机械性能、生物相容性、骨诱导能力等方面还存在着不足的缺陷，提供的多孔性骨修复材料具有优良的机械性能、生物相容性好、较好的骨诱导能力。提供的多孔性骨修复材料制备方法简单，成本低廉。In summary, the present invention overcomes the limitation of autologous bone source in the existing bone defect repair materials, and the shortcomings of artificial synthetic bone materials in terms of mechanical properties, biocompatibility, osteoinductive ability, etc., and provides porous The bone repair material has excellent mechanical properties, good biocompatibility, and good osteoinductive ability. The preparation method of the provided porous bone repair material is simple and the cost is low.
具体实施方式Detailed ways
下面通过实施例进一步描述本发明，本发明不仅限于所述实施例。The present invention is further described by the following examples, but the present invention is not limited to the examples.
实施例一Embodiment one
本例的多孔性骨修复材料组成如下：The composition of the porous bone repair material in this example is as follows:
β-磷酸三钙30%，人牙本质70%。β-tricalcium phosphate 30%, human dentin 70%.
本例的多孔性骨修复材料制备方法为：The preparation method of the porous bone repair material in this example is as follows:
按重量百分比计，取非晶体磷酸三钙（ACP）粉体30%，人牙本质粉体70%，将两种粉体混合均匀，以两种粉体总重为100%计，加入重量百分比20%制孔剂和0.5%粘接剂，再混合均匀，加入模具中，压制成型，经过高温烧结后制得多孔性骨修复材料。In terms of weight percentage, take 30% of amorphous tricalcium phosphate (ACP) powder and 70% of human dentin powder, mix the two powders evenly, and add the weight percentage based on the total weight of the two powders as 100%. 20% pore-forming agent and 0.5% adhesive, and then mixed evenly, added to the mold, pressed into shape, after high-temperature sintering to make a porous bone repair material.
制孔剂为硬脂酸。The pore forming agent is stearic acid.
粘接剂为聚乙烯醇，配成水溶液使用。The adhesive is polyvinyl alcohol, which is used as an aqueous solution.
高温烧结的具体工艺为：The specific process of high temperature sintering is:
将压制好的模型加热到300℃并保温0.5h，再升温至900℃，孵育0.5h，再升温至1180℃并保温2h。Heat the pressed model to 300°C and keep it warm for 0.5h, then raise the temperature to 900°C, incubate for 0.5h, then raise the temperature to 1180°C and keep it warm for 2h.
非晶体磷酸三钙（ACP）粉体按以下方法制备：Amorphous tricalcium phosphate (ACP) powder is prepared as follows:
将Ca(NO3)2和(NH4)2HPO4按照Ca/P比为1.5，分别配置成0.9 mol/L和0.6mol/L的溶液，室温下将(NH4)2HPO4溶液缓慢滴加到Ca(NO3)2溶液中，并用浓氨水调节pH值，使反应体系的pH值控制在8~10.5之间，并不断搅拌反应5h，陈化24h，产物经抽滤、去离子水洗涤、醇洗，于80℃下干燥待用。Ca(NO 3 ) 2 and (NH 4 ) 2 HPO 4 were prepared into 0.9 mol/L and 0.6 mol/L solutions respectively according to the Ca/P ratio of 1.5, and the (NH 4 ) 2 HPO 4 solution was slowly Add it dropwise to the Ca(NO 3 ) 2 solution, and adjust the pH value with concentrated ammonia water, so that the pH value of the reaction system is controlled between 8 and 10.5, and keep stirring for 5 hours, aging for 24 hours, and the product is filtered and deionized Wash with water, wash with alcohol, and dry at 80°C for use.
人牙本质粉体按以下方法制备：Human dentin powder is prepared as follows:
将人离体牙的牙周组织完全刮掉，利用牙科高速手机，沿牙齿轮廓去除牙釉质、牙骨质，同时利用机械手段去除牙髓组织和反应性牙本质；将所得人牙本质浸泡在去离子水中3小时，并使用超声波清洗机每小时清洁30分钟，去离子水每小时更换一次；之后用粉碎机将清洁后的人牙本质粉碎。The periodontal tissue of the human isolated tooth is completely scraped off, and the enamel and cementum are removed along the tooth contour with a high-speed dental handpiece, while the pulp tissue and reactive dentin are removed by mechanical means; the obtained human dentin is soaked in 3 hours in deionized water, and use an ultrasonic cleaner to clean for 30 minutes per hour, and the deionized water is replaced every hour; then use a pulverizer to pulverize the cleaned human dentin.
本例制备的多孔性骨修复材料经红外（IR）谱图分析，在609 cm-1、550 cm-1、1041cm-1、1121 cm-1处有PO4 3-的吸收峰。在1432cm-1处的吸收峰以及从2800 cm-1到3472 cm-1之间的吸收峰均为羟基吸收峰。X射线衍射（XRD）谱图表明，在2θ=31°，2θ=27°，2θ=34°，2θ=32°，2θ=46°，2θ=52°附近都有其特征峰。红外和X射线衍射的分析结果表明：本例制备的多孔性骨修复材料为β-磷酸三钙与人牙本质的混合物。The porous bone repair material prepared in this example has the absorption peaks of PO 4 3- at 609 cm -1 , 550 cm -1 , 1041 cm -1 , and 1121 cm -1 through infrared (IR) spectrum analysis. The absorption peak at 1432cm -1 and the absorption peaks from 2800 cm -1 to 3472 cm -1 are all hydroxyl absorption peaks. The X-ray diffraction (XRD) spectrum shows that there are characteristic peaks around 2θ=31°, 2θ=27°, 2θ=34°, 2θ=32°, 2θ=46°, and 2θ=52°. The results of infrared and X-ray diffraction analysis show that the porous bone repair material prepared in this example is a mixture of β-tricalcium phosphate and human dentin.
本例制备的多孔性骨修复材料最大载荷为68.44N，最大载荷变形为0.23 mm，弹性模量为879.05 N/mm2。The porous bone repair material prepared in this example has a maximum load of 68.44N, a maximum load deformation of 0.23 mm, and an elastic modulus of 879.05 N/mm 2 .
实施例二Embodiment two
本例的多孔性骨修复材料组成如下：β-磷酸三钙50%，人牙本质50%。The composition of the porous bone repair material in this example is as follows: β-tricalcium phosphate 50%, human dentin 50%.
本例的多孔性骨修复材料制备方法为：The preparation method of the porous bone repair material in this example is as follows:
按重量百分比计，取非晶体磷酸三钙（ACP）粉体50%，人牙本质粉体50%，将两种粉体混合均匀，以两种粉体总重为100%计，加入重量百分比15%制孔剂和0.8%粘接剂，再混合均匀，加入模具中，压制成型，经过高温烧结后制得多孔性骨修复材料。In terms of weight percentage, take 50% of amorphous tricalcium phosphate (ACP) powder and 50% of human dentin powder, mix the two powders evenly, and add the weight percentage based on the total weight of the two powders as 100%. 15% pore-forming agent and 0.8% adhesive, and then mixed evenly, put into the mold, press molding, after high-temperature sintering to make a porous bone repair material.
制孔剂为聚乙二醇。The pore forming agent is polyethylene glycol.
粘接剂为羧甲基纤维素，配成水溶液使用。The binder is carboxymethyl cellulose, and it is used as an aqueous solution.
本例制备的多孔性骨修复材料最大载荷为70.25N，最大载荷变形为0.25 mm，弹性模量为986.08 N/mm2。The porous bone repair material prepared in this example has a maximum load of 70.25N, a maximum load deformation of 0.25 mm, and an elastic modulus of 986.08 N/mm 2 .
其余同实施例一。All the other are the same as embodiment one.
实施例三Embodiment three
本例的多孔性骨修复材料组成如下：β-磷酸三钙70%，人牙本质30%。The composition of the porous bone repair material in this example is as follows: β-tricalcium phosphate 70%, human dentin 30%.
本例的多孔性骨修复材料制备方法为：The preparation method of the porous bone repair material in this example is as follows:
按重量百分比计，取非晶体磷酸三钙（ACP）粉体70%，人牙本质粉体30%，将两种粉体混合均匀，以两种粉体总重为100%计，加入重量百分比10%制孔剂和1%粘接剂，再混合均匀，加入模具中，压制成型，经过高温烧结后制得多孔性骨修复材料。In terms of weight percentage, take 70% of amorphous tricalcium phosphate (ACP) powder and 30% of human dentin powder, mix the two powders evenly, and add the weight percentage based on the total weight of the two powders as 100%. 10% pore-forming agent and 1% adhesive, mixed evenly, added to the mold, pressed into shape, and made into a porous bone repair material after high-temperature sintering.
制孔剂为聚乙烯吡咯烷酮。The pore forming agent is polyvinylpyrrolidone.
粘接剂为聚乙烯醇缩丁醛，配成水溶液使用。The adhesive is polyvinyl butyral, which is used as an aqueous solution.
本例制备的多孔性骨修复材料最大载荷为83.85N，最大载荷变形为0.25 mm，弹性模量为801.71 N/mm2。The porous bone repair material prepared in this example has a maximum load of 83.85N, a maximum load deformation of 0.25 mm, and an elastic modulus of 801.71 N/mm 2 .
其余同实施例一。All the other are the same as embodiment one.
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