CN107846947A - Strengthen salt composite and preparation method thereof - Google Patents

Strengthen salt composite and preparation method thereof Download PDF

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Publication number
CN107846947A
CN107846947A CN201680044069.1A CN201680044069A CN107846947A CN 107846947 A CN107846947 A CN 107846947A CN 201680044069 A CN201680044069 A CN 201680044069A CN 107846947 A CN107846947 A CN 107846947A
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enhancing
salt
salt composite
composite
immunomodulator compounds
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Inventor
亚夫拉罕·巴尼埃尔
迈克尔·兹维利
罗妮特·罗姆
西万·内厄姆
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Duke Mattuck Co Ltd
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Duke Mattuck Co Ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/40—Table salts; Dietetic salt substitutes
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/88—Taste or flavour enhancing agents
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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  • Health & Medical Sciences (AREA)
  • Nutrition Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Seasonings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)

Abstract

There is provided herein compared to its salt component have improve salinity or reduction Unit Weight sodium content composition, and preparation method thereof.

Description

Strengthen salt composite and preparation method thereof
Background technology
Present disclosure is related to enhancing salt composite.More specifically, present disclosure is related to has compared to its salt component The salinity and/or the enhancing salt composite of the sodium content of reduction being improved, and the preparation method of said composition.
Sodium chloride (NaCl) salt is generally used for being seasoned food plus taste or preservation.Excessive sodium intake can cause one A little health problems.In such circumstances it is desirable to have the salinity of increase salt or reduce the amount of salt, while reach the side of equal salinity Method.This disclosure provides the manipulation of relation between salinity and salt amount or sodium content so that desired salinity can be with relatively low salt Amount or relatively low sodium value are associated, while keep the sense organ overview similar to salt.This effect belongs to following combinations by proposing The salt of the other composition forms of species is achieved.Salt is provided by with composition forms as described herein, is maintained to salt Salinity perception, while reduce its sodium value.
The content of the invention
In one aspect, this disclosure provides the method for producing enhancing salt composite, it is included salt and reinforcing agent Compound is mixed to produce enhancing salt composite；Wherein compared with reference composition, the enhancing salt composite has what is improved Salinity；And wherein described reference composition by species and amount on it is described enhancing salt composite identical inclusion form, But be free of the enhancing immunomodulator compounds.In some embodiments, methods described further comprises dissolving the salt and the increasing Strong immunomodulator compounds strengthen salt composite solution to produce.In some embodiments, methods described further comprises described in regulation The pH for strengthening salt composite solution is horizontal.In some embodiments, methods described further comprises drying the enhancing salt group Compound.In some embodiments, methods described further comprises strengthening salt composite described in sonication.In some embodiments In, methods described further comprises being homogenized the enhancing salt composite.In some embodiments, methods described further comprises The enhancing salt composite is set to sieve.In some embodiments of methods described, the salt includes sodium chloride.In methods described Some embodiments in, it is more that the enhancing immunomodulator compounds are selected from amino acid, peptide, protein, metal oxide, chitosan, shell Sugar and its any combination.In some embodiments of methods described, the amino acid is selected from alanine, arginine, asparagus fern acyl Amine, aspartic acid, cysteine, glutamic acid, glutamine, glycine, histidine, isoleucine, leucine, lysine, first Methyllanthionine, phenylalanine, proline, serine, threonine, tryptophan, tyrosine, valine, selenocysteine, Bi Kalai Propylhomoserin and its any combination.In some embodiments of methods described, the amino acid is glycine.The one of methods described In a little embodiments, the amino acid is glycine and the salt includes sodium chloride.In some embodiments of methods described, The peptide is selected from dipeptides, tripeptides, tetrapeptide, pentapeptide and its any combination.In some embodiments of methods described, the enhancing Immunomodulator compounds are metal oxide.In some embodiments of methods described, the enhancing immunomodulator compounds are silica. In some embodiments of methods described, the enhancing immunomodulator compounds are metal oxide and the salt includes sodium chloride.Institute In some embodiments for stating method, the enhancing immunomodulator compounds are silica and the salt includes sodium chloride.In the side In some embodiments of method, the enhancing immunomodulator compounds strengthen the combination of immunomodulator compounds for two or more.In the side In some embodiments of method, the enhancing salt composite includes the reinforcing agent relative to salt at most about 10% (w/w) Compound.In some embodiments of methods described, the enhancing salt composite is included relative to salt about 0.1-10% (weights Amount/weight) enhancing immunomodulator compounds.In some embodiments of methods described, it is described enhancing salt composite include relative to The enhancing immunomodulator compounds of salt at most about 5% (w/w).In some embodiments of methods described, the enhancing salt group Compound includes the enhancing immunomodulator compounds relative to salt about 0.1-5% (w/w).In some embodiments of methods described In, the salinity improves at least 10%, 20%, 30%, 40% or 50%.
On the other hand, this disclosure provides the enhancing salt composite comprising salt and enhancing immunomodulator compounds；Wherein institute Enhancing salt composite is stated with the enhancing immunomodulator compounds relative to salt at most about 10% (w/w)；Wherein described enhancing salt Composition has the salinity improved compared to reference composition；And wherein described reference composition by species and amount on and institute Enhancing salt composite identical inclusion composition is stated, but is free of the enhancing immunomodulator compounds.In some embodiments, the increasing Strong salt composite includes the enhancing immunomodulator compounds relative to salt about 0.1-10% (w/w).In some embodiments, institute State enhancing salt composite and include the enhancing immunomodulator compounds relative to salt at most about 5% (w/w).In some embodiments In, the enhancing salt composite includes the enhancing immunomodulator compounds relative to salt about 0.1-5% (w/w).In the enhancing In some embodiments of salt composite, the salt includes sodium chloride.In some embodiments of the enhancing salt composite, The enhancing immunomodulator compounds are selected from amino acid, peptide, protein, metal oxide, chitosan, chitin and its any combination. In some embodiments of the enhancing salt composite, the amino acid is selected from alanine, arginine, asparagine, asparagus fern ammonia Acid, cysteine, glutamic acid, glutamine, glycine, histidine, isoleucine, leucine, lysine, methionine, benzene Alanine, proline, serine, threonine, tryptophan, tyrosine, valine, selenocysteine, pyrrolysine and its Any combination.In some embodiments of the enhancing salt composite, the amino acid is glycine.In the enhancing salt group In some embodiments of compound, the amino acid is glycine and the salt includes sodium chloride.In the enhancing salt composite Some embodiments in, the peptide is selected from dipeptides, tripeptides, tetrapeptide, pentapeptide and its any combination.In the enhancing salt composite Some embodiments in, it is described enhancing immunomodulator compounds be metal oxide.In some embodiment party of the enhancing salt composite In case, the enhancing immunomodulator compounds are silica.In some embodiments of the enhancing salt composite, the reinforcing agent Compound is metal oxide and the salt includes sodium chloride.It is described in some embodiments of the enhancing salt composite Enhancing immunomodulator compounds are silica and the salt includes sodium chloride.In some embodiments of the enhancing salt composite, The enhancing immunomodulator compounds strengthen the combination of immunomodulator compounds for two or more.In some implementations of the enhancing salt composite In scheme, the enhancing salt composite is solid.In some embodiments of the enhancing salt composite, the enhancing salt group Compound is liquid.In some embodiments of the enhancing salt composite, the salinity improves at least 10%, 20%, 30%, 40% or 50%.In some embodiments of the enhancing salt composite, the composition is substantially by salt and reinforcing agent Compound forms.In some embodiments of the enhancing salt composite, the composition by salt and reinforcing agent compound group into.
It yet still another aspect, this disclosure provides the composition for including food or edible product, it includes public herein The enhancing salt composite opened.In some embodiments of the composition, the food or edible product be selected from bakee thing, Seasoning (such as catsup, sweetening material), sauce (such as fish sauce, soy sauce, pasta sauce (spaghetti sauce), tomato Sauce, according to burning sauce, oyster sauce, thick chilli sauce, beefsteak sauce, barbecue sauce, Worcestershire sauce), condiment, meat (such as pork, ox Meat, meat of a sheep, chevon, poultry meat, chicken, turkey meat, fish, seafood, shellfish or shell-fish (shellfish), crab, dragon Shrimp/extra large huge legendary turtle shrimp (lobster), clam, oyster, shrimp), meat processing (such as sausage, salami (salami), prepared food meat, Pork luncheon meat, butcher's meat, bacon, biltong, canned meat, Minced Steak, bacon, ham, roast beef, beefbacon, head cheese (head Cheese), pork product (charcuterie), pork head meat (pate), terrine food (terrine), galantine, foie gras chicken Roll up (ballotine)), hamburger, egg, vegetables (such as fresh vegetables, ripe vegetables, canned vegetables, refrigerated vegetables, fermented vegetable, Pickless, salted vegetables), cereal, pie, Custard cake (quiche), pasta (pasta), meat alternative, bean curd, peanut, Nut, seed, snacks (such as pretzel (pretzels), biscuit (crackers), potato chips, chips), cheese, spices, soup (such as canned soup, instant soups), dairy products and its any combination.
It yet still another aspect, this disclosure provides the method for making food or edible product, it is included with public herein The enhancing salt composite opened substitutes at least a portion of salt component.
Quote and be incorporated to
The all publications, patents and patent applications mentioned in this specification are both incorporated herein by reference, and its degree is such as With pointing out especially and that individually each single publication, patent or patent application is incorporated by reference into.
The novel feature of present disclosure especially proposes in the appended claims.By reference to below to utilizing The detailed description that the illustrative embodiment of present disclosure principle is illustrated by, it will obtain to the feature of present disclosure and Advantage is better understood from.
Embodiment
Introduction
Present disclosure is related to salt combination that is can be used alone or may be added to that or be further processed into edible product Thing.This paper enhancing salt composite includes salt and enhancing immunomodulator compounds.This paper enhancing salt composite can be than similar control Composition (for example, upper with the salt identical inclusion but without the composition of enhancing immunomodulator compounds included in species and amount) taste Road is more salty.
Definition
As it is used herein, term " salt " refers to edible salt, it produces saline taste in independent eat.Salt can be day So existing salt；For example, it can be separation, purifying salt.The non-limiting examples of salt include sodium chloride, potassium chloride, chlorination Ammonium, sodium salt, sylvite, ammonium salt, chloride salt, mosanom, sodium ascorbate, sodium acid carbonate (sodium bicarbonate), sodium benzoate, casein Sour sodium, sodium citrate, sodium hydroxide, saccharin sodium, stearoyl lactate, sodium sulfite, disodium hydrogen phosphate, monosodium glutamate (MSG), Tertiary sodium phosphate, Sodium guanylate, inosine acid disodium, ribonucleotide acid disodium, table salt (table salt), salt (common salt), sea salt, salt compounded of iodine, Jew's salt (Kosher salt), rock salt, flavor salt, seasoning salt, purified salt and smoke Salt.Salt can be the combination of two or more different salt.Salt can be fish sauce, soy sauce or herbaceous plant (for example, saltbush, shore Lamb's-quarters (Atriplex)).
As it is used herein, term " enhancing immunomodulator compounds " refers to the food grade compounds that can be combined with salt.Reinforcing agent Compound can be by forming electrostatic interaction, hydrogen bond, ionic interaction, Coordination interaction, non-covalent phase interaction with salt Combined with, Van der Waals interaction or its any combination with salt.Enhancing immunomodulator compounds can be combined with salt with provide different from pair According to the salinity of the characteristic of composition, such as raising.It can be milk-toast, unpalatable or scentless to strengthen immunomodulator compounds. Enhancing immunomodulator compounds optionally meet such as Food Chemical Codex (Food Chemicals Codex, FCC), European Union's decree (European Directive) or Japanese food additives codes and standards (Japan'sSpecifications and Standards for Food Additives) described in test request.Enhancing immunomodulator compounds can be purified or separate.Enhancing Immunomodulator compounds can be the combination of two or more difference enhancing immunomodulator compounds.In some cases, enhancing immunomodulator compounds can be 2nd, 3,4,5,6,7,8, the 9, combinations of the different enhancing immunomodulator compounds of 10 kind or more kind.In some cases, salt composite is strengthened Salinity can have the ratio between enhancing immunomodulator compounds that maximum salinity is provided and salt.In some cases, reinforcing agent compound phase is made Increase above maximum point for the amount of salt and can reduce the salinity of composition.In some cases, when the amount of enhancing immunomodulator compounds is small When maximum point, composition not fully benefits from the salinity enhancing effect of the enhancing immunomodulator compounds.Strengthen the non-of immunomodulator compounds Limitative examples include amino acid, peptide, protein, metal oxide (such as titanium dioxide, silica (such as silica), oxygen Change zinc, aluminum oxide), chitosan, chitin and its any combination.
The non-limiting examples of amino acid include alanine, arginine, asparagine, aspartic acid, cysteine, paddy ammonia Acid, glutamine, glycine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, proline, silk Propylhomoserin, threonine, tryptophan, tyrosine, valine, selenocysteine and pyrrolysine.In some cases, amino acid For produce (proteinogenic) of albumen, it is natural, standard, off-gauge, non-standard, required, nonessential or Non-natural amino acid.In some cases, amino acid is alpha amino acid, beta amino acids, γ amino acid or δ amino acid.At some In the case of, amino acid have positively charged side chain, negatively charged side chain, the uncharged side chain of polarity, non-polar sidechain, Hydrophobic side chain, hydrophilic side chain, aliphatic lateral chain, aromatic side chains, cyclic pendant, acyclic side chain, basic side chain or acid side-chain. Under certain situation, amino acid is L- stereoisomers or l-amino acid.In some cases, amino acid be D- stereoisomers or D- amino acid.In some cases, amino acid is neutral charge.In some cases, amino acid be anion, cation, Amphion or salt form (for example, sodium glutamate form of glutamic acid).In some cases, amino acid is derivative.One In the case of a little, amino acid has N- lactoyls-X architecture, and wherein X represents amino acid residue.In some cases, there is N- lactoyls-X The amino acid of structure be selected from N- (S)-lactoyl-Glu, N- (S)-lactoyl-Ala, N- (S)-lactoyl-Leu, N- (S)-lactoyl-Tyr, N- (S)-lactoyl-Met and its any combination.
Peptide can include two or more amino acid.In some cases, peptide can include about 2,3,4,5,6,7,8,9,10, 11、12、13、14、15、16、17、18、19、20、21、22、23、24、25、30、35、40、45、50、55、60、65、70、75、 80th, 85,90,95 or 100 amino acid.In some cases, peptide can include at least 2,3,4,5,6,7,8,9,10,11,12, 13、14、15、16、17、18、19、20、21、22、23、24、25、30、35、40、45、50、55、60、65、70、75、80、85、 90th, 95 or 100 amino acid.In some cases, peptide may comprise up to 2,3,4,5,6,7,8,9,10,11,12,13,14, 15th, 16,17,18,19,20,21,22,23,24,25,30,35,40,45,50,55,60,65,70,75,80,85,90,95 or 100 amino acid.In some cases, peptide can include 2-100,2-50,2-20,2-10,2-9,2-8,2-7,2-6,2-5,2- 4、2-3、3-100、3-50、3-20、3-10、3-9、3-8、3-7、3-6、3-5、3-4、4-100、4-50、4-20、4-10、4-9、 4-8、4-7、4-6、4-5、5-100、5-50、5-20、5-10、5-9、5-8、5-7、5-6、6-100、6-50、6-20、6-10、6- 9th, 6-8 or 6-7 amino acid.In some cases, peptide can be dipeptides, tripeptides, tetrapeptide or pentapeptide.In some cases, peptide (example Such as tripeptides) contain hydrophobic amino acid residue (such as alanine (Ala), methionine (Met), valine (Val), leucine (Leu), proline (Pro), phenylalanine (Phe), tyrosine (Tyr), isoleucine (Ile) or tryptophan (Trp)) and at least One acidic amino acid residue (such as glutamic acid (Glu) or aspartic acid (Asp)).In some cases, peptide (such as tripeptides) Contain two acidic amino acid residues.In some cases, tripeptides is selected from Glu-Glu-Leu, Glu (Glu-Leu) or γ Glu- Glu-Leu、Leu-Glu-Glu、Glu-Asp-Phe、Glu-Glu-Ile、Asp-Glu-Leu、Glu-Leu-Glu、Glu-Asp- Ile, Asp-Glu-Ile, Glu-Glu-Val, Lys-Asp-Ile, Asp-Ile-Gly and its any combination.
As it is used herein, term " reference composition " refers to the composition compared with strengthening salt composite. Under certain situation, reference composition includes salt, but not comprising the enhancing immunomodulator compounds of the enhancing salt composite compared with it. In some cases, the salt in reference composition is form dissociate, unassociated.Reference composition can be included in species and amount The upper salt identical inclusion with enhancing salt composite.Reference composition can be by the salt in species and amount with enhancing salt composite Identical inclusion forms.Reference composition can by species and amount on enhancing salt composite identical inclusion form, but Without enhancing immunomodulator compounds.
As it is used herein, term " salinity of raising " or " higher perception salinity " refer to it is stronger in case of human or Higher saline taste sense.Compared with reference composition compared with it, salinity improve enhancing salt composite taste it is more salty. The enhancing salt composite that the salinity of small amount (by weight or stereometer) improves can be scarce with relatively large (by weight or stereometer) The reference composition of the salinity improved less produces identical saline taste sense.With free, the non-association with similar quantity (by weight) The reference composition of the salt of form is compared, and the enhancing salt composite that salinity improves can produce higher perception salinity and with lower Sodium content.For example, 1.0 grams of enhancing salt composites comprising about 0.01 gram of enhancing immunomodulator compounds and about 0.99 gram of salt it is comparable comprising About 0.99 gram of salt and reference composition not comprising enhancing immunomodulator compounds produces higher perception salinity.
As it is used herein, term " edible product " refers to be eaten (such as by feeding, chewing, tasting, drinking With or swallow) product.Edible product may include food product as non-limiting examples.Food product includes but is not limited to Soup (such as canned soup, instant soups), whipped cream, bakee thing, seasoning (such as catsup, sweetening material), sauce (such as fish sauce, Soy sauce, pasta sauce, catsup, according to burn sauce, oyster sauce, thick chilli sauce, beefsteak sauce, barbecue sauce, Worcestershire sauce), breast Product, condiment, meat (such as pork, beef, meat of a sheep, chevon, poultry meat, chicken, turkey meat, fish, seafood, shellfish or Shell-fish, crab, lobster/extra large huge legendary turtle shrimp, clam, oyster, shrimp), meat processing (such as sausage, salami, prepared food meat, noon Meal meat, butcher's meat, bacon, biltong, canned meat, Minced Steak, bacon, ham, roast beef, beefbacon, head cheese, pork product, pig Head meat, terrine food, galantine, foie gras chicken croquette), hamburger, egg, vegetables (such as fresh vegetables, ripe vegetables, canned vegetables, Refrigerated vegetables, fermented vegetable, pickless, salted vegetables), cereal, pie, Custard cake, pasta, meat alternative, bean curd, flower Life, nut, seed, snacks (such as pretzel, biscuit, potato chips, chips), spices and cheese.In some cases, food produces Product are frozen, freeze, be canned, preserving, pickling, drying, smoking, toasting, fermenting, being pickled, jelly is made, with base extraction or oil It is fried.
As it is used herein, term " solvent " refer to can with enhancing salt composite or strengthen salt composite one kind or more (such as salt or enhancing immunomodulator compounds) mixing of kind component is combined for dissolving the enhancing salt composite or the enhancing salt The liquid of one or more components of thing.The non-limiting examples of solvent include water, ethanol and isopropanol.The solvent can be can Drink.The non-limiting examples of water include purified water, distilled water, double distilled water, deionized water, distillation deionized water, drink Water, well water, running water, spring, bottled water, carbonated water, mineral water plus taste water or its any combination.Solvent can be two kinds or The combination of more kinds of different solvents.
Enhancing immunomodulator compounds can include silica or silica (SiO2).In some embodiments, immunomodulator compounds are strengthened For silica or silica (SiO2).The example of the silica considered herein includes but is not limited to colloidal silica；Silica granule (such as Particle comprising silica)；Precipitated silica；Celelular silica；Colloidal silica；Scattered silica；Silica gel；Ludox；Porous precipitated silica； Silica gel；Amorphous silica；And precipitated amorphous silica.The example of the silica enhancing immunomodulator compounds considered herein includes but unlimited In(W.R.Grace&Co)、SM 660(W.R.Grace&Co)、 (W.R.Grace&Co)、(W.R.Grace&Co)、(W.R.Grace&Co)、 (W.R.Grace&Co)、Silica(W.R.Grace&Co)、(Solvay)、38AB (Solvay) and(HUBER).In some cases, wrap it is silica containing enhancing immunomodulator compounds have about or At least about 98% or 99% SiO2(butt) content.In some cases, silica containing enhancing immunomodulator compounds are wrapped to close Into caused, flowing freely, unbodied, solid, white, spray drying or powder.
In some cases, strengthen immunomodulator compounds can have at most 1,2,3,4,5,7,8,9,10,11,12,13,14,15, 20th, 25,30,35,40,45,50,55,60,65,70,75,80,85,90,95 or 100 microns of average grain diameter.In certain situation Under, enhancing immunomodulator compounds can have about or at least 1,2,3,4,5,7,8,9,10,11,12,13,14,15,20,25,30,35, 40th, 45,50,55,60,65,70,75,80,85,90,95 or 100 microns of average grain diameter.In some embodiments, strengthen Immunomodulator compounds have 1 to 100,5 to 100,1 to 80,10 to 80,1 to 50,10 to 50,1 to 30,1 to 10,3.5 to 65 or 10 to 30 microns of average grain diameter.In some cases, by MalvernMastersizer, Malvern Mastersizer 2000, Laser diffraction or laser c ILAS measure particle mean sizes.In some cases, strengthening immunomodulator compounds has by Malvern Mastersizer is determined as about 3,7,9,10 or 19 microns of average grain diameter；Determined by Malvern Mastersizer 2000 It is about 10,10.1 or 19.0 microns of average grain diameter；Pass through the average grain diameter that determination of laser diffraction is about 12-25 microns；It is or logical Cross the average grain diameter that laser CILAS is determined as about 13,14,15 or 17 microns.In some cases, strengthen immunomodulator compounds to more than 25 microns of wet screenings having less than about 0.01% remain, to having at most about 0.2% wet screening to remain more than 150 microns, or it is right There is the wet screening residual (Mocker) less than 0.1% or 0.2% more than 40 microns.
Enhancing immunomodulator compounds can have high-specific surface area.In some cases, strengthening immunomodulator compounds can be with about or at least 20、30、40、50、60、70、80、90、100、110、120、130、140、150、160、170、180、190、200、210、220、 230、240、250、260、270、280、290、300、350、400、450、500、550、600、650、700、750、800、850、 900th, 950 or 1000m2/ g specific surface area.In some cases, strengthen immunomodulator compounds can have at most 20,30,40,50, 60、70、80、90、100、110、120、130、140、150、160、170、180、190、200、210、220、230、240、250、 260th, 270,280,290,300,350,400,450,500,550,600,650,700,750,800,850,900,950 or 1000m2/ g specific surface area.In some cases, enhancing immunomodulator compounds have about 140-360m2/ g surface area (BET).
Strengthen other elements of the immunomodulator compounds containing trace.In some cases, immunomodulator compounds are strengthened with about or small In about 0.03% or 0.05% Fe2O3(combustion product) content.In some cases, strengthening immunomodulator compounds has about or is less than About 0.2% Al2O3(combustion product) content.In some cases, strengthening immunomodulator compounds has the Fe (beer for being less than about 2.0% It is soluble) content.In some cases, strengthening immunomodulator compounds has Ca (beer soluble) content for being less than about 5.0%.One In the case of a little, enhancing immunomodulator compounds have the chloride content less than about 0.1%.In some cases, immunomodulator compounds tool is strengthened There is the electrolyte less than about 2.2%, 3.0% or 0.5% (as Na2SO4).In some cases, enhancing immunomodulator compounds have small In about 25ppm content of beary metal.
Enhancing immunomodulator compounds can be at dewatering state (such as annealing or dry).For example, enhancing immunomodulator compounds are dried Mass lost afterwards can be about or at most about 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9% or 10%.In some feelings Under condition, reinforcing agent can be heated (for example, at 105 DEG C, 145 DEG C, 160 DEG C, 400 DEG C or 1000 DEG C) at least 0.5,1,1.5, 2nd, make a return journey within 2.5,3,3.5 or 4 hours moisture removal and dry reinforcing agent.In some cases, strengthen immunomodulator compounds at 145 DEG C to add Heat has about or the moisture less than about 1.5%, 3%, 5% or 7% after 4 hours；After being heated 2 hours at 105 DEG C have about or Moisture less than about 4%, 6% or 7%；With about 3.0% to juicy at 160 DEG C；With about or at most about 40% or 63% drying loss；There is about 59.0-65.0% drying loss at 160 DEG C；Or have after being heated 1 hour at 1000 DEG C Have about or the combustible loss less than about 5%, 8.5% or 9%.
In some cases, strengthen immunomodulator compounds in 5% waterborne suspension or slurries have about 5.4,6.8,6.9, 7.0th, 3.5-5.5,3.5-9.0,3.0-9.0,6.4-7.0,6.4-7.4,6.0-7.6,6.0-8.0 or 6.0-8.2 pH value.
In some cases, strengthen immunomodulator compounds have about 190-280cc/100g or about 80g/100g, 200g/100g or 300g/100g oil absorption.In some cases, strengthening immunomodulator compounds has about 248-324cc/100g dioctyl adipate Adsorb (DOA).In some cases, strengthen immunomodulator compounds have about 190mL/100g, 210mL/100g, 230mL/100g or 240mL/100g or n-butyl phthalate (DBP) absorption more than 185mL/100g.
As it is used herein, term " about " can be regarded as setting value 15%, 14%, 13%, 12%, 11%, 10%th, within 9%, 8%, 7%, 6%, 5%, 4%, 3%, 2%, 1%, 0.5%, 0.1%, 0.05% or 0.01%.
In some cases, term " part " can be regarded as reference value about 0.01%, 0.05%, 0.1%, 0.5%, 1%th, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14%, 15%, 16%, 17%, 18%th, 19%, 20%, 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%th, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, 99%, 99.1%, 99.2%, 99.3%th, 99.4%, 99.5%, 99.6%, 99.7%, 99.8%, 99.9% or 100%；Reference value at least 0.01%, 0.05%th, 0.1%, 0.5%, 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14%th, 15%, 16%, 17%, 18%, 19%, 20%, 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%th, 70%, 75%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, 99%th, 99.1%, 99.2%, 99.3%, 99.4%, 99.5%, 99.6%, 99.7%, 99.8%, 99.9% or 100%；Or Reference value at most 0.01%, 0.05%, 0.1%, 0.5%, 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%th, 11%, 12%, 13%, 14%, 15%, 16%, 17%, 18%, 19%, 20%, 25%, 30%, 35%, 40%, 45%th, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%th, 97%, 98%, 99%, 99%, 99.1%, 99.2%, 99.3%, 99.4%, 99.5%, 99.6%, 99.7%, 99.8%th, 99.9% or 100%.
In some cases, term " one or more (one or more) " can be regarded as about 1,2,3,4,5,6,7,8,9, 10、11、12、13、14、15、16、17、18、19、20、25、30、35、40、45、50、55、60、65、70、75、80、85、90、95 Or 100 kinds (individual)；At least 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,25,30,35, 40th, 45,50,55,60,65,70,75,80,85,90,95 or 100 kind (individual)；Or at most 1,2,3,4,5,6,7,8,9,10,11, 12nd, 13,14,15,16,17,18,19,20,25,30,35,40,45,50,55,60,65,70,75,80,85,90,95 or 100 Kind (individual).Strengthen salt composite
Strengthen salt composite and include salt and enhancing immunomodulator compounds.The enhancing salt composite of saline taste enhancing can be assigned with less salt Give the desired salinity of food.Can be by the way that salt be strengthened into immunomodulator compounds (such as amino acid, peptide, protein, metals with one or more Oxide, chitosan or chitin) mix to form enhancing salt composite.Enhancing salt composite can be purified or separated.Increase Strong salt composite is preferably substantially uniform or homogeneous.Strengthen salt composite can be liquid (for example, solution, colloid, suspension, Dispersion liquid) form.Strengthen the form that salt composite can be solid (for example, powder, particulate, particle, crystal).In certain situation Under, enhancing salt composite is dry and/or dehydration.
The physical property for strengthening salt composite or its each component can be for example, by elementary analysis, density, viscosity, micro- Art, element mapping, refractive index (RI), transmission fourier transform infrared spectroscopy (FTIR), inductively coupled plasma (ICP), Thermogravimetric analysis (TGA), dynamic light scattering (DLS) or laser diffraction characterize.For example, enhancing salt composite can be with small particle Powder.The particle diameter (such as by DLS or laser diffraction) of measurable enhancing salt composite.Can be by using with different big The sieve in small aperture carries out size fractionation to measure the distribution of particle diameter to particle.Surface area can by Brunauer- Emmett-Teller (BET) theories measure.The physical property of enhancing salt composite can influence its taste properties.For example, enhancing The perception salinity of salt composite can be related to particle diameter distribution.
The ratio of the enhancing immunomodulator compounds amount determined and salt amount can be had by strengthening salt composite.The ratio of such amount can base Determined in quality, weight, volume or molal quantity.In some cases, it can be at least to strengthen immunomodulator compounds and the ratio of salt 0.05%th, 0.1%, 0.15%, 0.2%, 0.25%, 0.3%, 0.35%, 0.4%, 0.45%, 0.5%, 0.6%, 0.7%, 0.8%th, 0.9%, 1.0%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2.0%th, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, 3.0%, 3.1%, 3.2%th, 3.3%, 3.4%, 3.5%, 3.6%, 3.7%, 3.8%, 3.9%, 4.0%, 4.1%, 4.2%, 4.3%, 4.4%th, 4.5%, 4.6%, 4.7%, 4.8%, 4.9%, 5.0%, 5.5%, 6.0%, 6.5%, 7.0%, 7.5%, 8.0%th, 8.5%, 9.0%, 9.5% or 10.0%.In some cases, strengthen immunomodulator compounds and the ratio of salt can be up to 0.05%th, 0.1%, 0.15%, 0.2%, 0.25%, 0.3%, 0.35%, 0.4%, 0.45%, 0.5%, 0.6%, 0.7%, 0.8%th, 0.9%, 1.0%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2.0%th, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, 3.0%, 3.1%, 3.2%th, 3.3%, 3.4%, 3.5%, 3.6%, 3.7%, 3.8%, 3.9%, 4.0%, 4.1%, 4.2%, 4.3%, 4.4%th, 4.5%, 4.6%, 4.7%, 4.8%, 4.9%, 5.0%, 5.5%, 6.0%, 6.5%, 7.0%, 7.5%, 8.0%th, 8.5%, 9.0%, 9.5% or 10.0%.In some cases, strengthen immunomodulator compounds and the ratio of salt can be about 0.05%th, 0.1%, 0.15%, 0.2%, 0.25%, 0.3%, 0.35%, 0.4%, 0.45%, 0.5%, 0.6%, 0.7%, 0.8%th, 0.9%, 1.0%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2.0%th, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, 3.0%, 3.1%, 3.2%th, 3.3%, 3.4%, 3.5%, 3.6%, 3.7%, 3.8%, 3.9%, 4.0%, 4.1%, 4.2%, 4.3%, 4.4%th, 4.5%, 4.6%, 4.7%, 4.8%, 4.9%, 5.0%, 5.5%, 6.0%, 6.5%, 7.0%, 7.5%, 8.0%th, 8.5%, 9.0%, 9.5% or 10.0%.In some cases, strengthen immunomodulator compounds and the ratio of salt can be about 0.1- 10.0%th, 0.1-9.0%, 0.1-8.0%, 0.1-7.0%, 0.1-6.0%, 0.1-5.0%, 0.1-4.0%, 0.1-3.0%, 0.1-2.0%, 0.1-1.0%, 0.5-10%, 0.5-9.0%, 0.5-8.0%, 0.5-7.0%, 0.5-6.0%, 0.5- 5.0%th, 0.5-4.0%, 0.5-3.0%, 0.5-2.0%, 0.5-1.0%, 1.0-10.0%, 1.0-9.0%, 1.0-8.0%, 1.0-7.0%, 1.0-6.0%, 1.0-5.0%, 1.0-4.0%, 1.0-3.0%, 1.0-2.0%, 2.0-5.0%, 2.0- 4.0%th, 2.0-3.5% or 2.0-3.0%.The ratio of enhancing immunomodulator compounds and salt can be about 0.1-10.0%.
In some cases, enhancing salt composite as described herein is acid, neutral or alkaline.In certain situation Under, enhancing salt composite have about or at least about 2,2.5,3,3.5,4,4.5,5,5.5,6,6.1,6.2,6.3,6.4,6.5, 6.6、6.7、6.8、6.9、7、7.1、7.2、7.3、7.4、7.5、7.6、7.7、7.8、7.9、8、8.1、8.2、8.3、8.4、8.5、 9th, 9.5 or 10 pH.In some cases, strengthen salt composite have at most about 2,2.5,3,3.5,4,4.5,5,5.5,6, 6.1、6.2、6.3、6.4、6.5、6.6、6.7、6.8、6.9、7、7.1、7.2、7.3、7.4、7.5、7.6、7.7、7.8、7.9、8、 8.1st, 8.2,8.3,8.4,8.5,9,9.5 or 10 pH.In some cases, about 2 to about 8, about 4 can be had by strengthening salt composite To about 8, about 6 to the about 8 or pH of about 7 to about 8.5.
The salinity improved compared to reference composition can be had by strengthening salt composite.Preferably, reference composition is salt, and It is not the enhancing immunomodulator compounds of the enhancing salt composite compared with it.Strengthening salt composite can be with the salty of the raising quantified Degree.The salinity of the raising can be determined by sensory testing.This document describes the example of sense organ taste's test.
In some cases, relative to reference composition, strengthen the salinity of salt composite can improve at least 5%, 10%, 20%th, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 100%, 110%, 120%, 130%, 140%, 150%, 160%th, 170%, 180%, 190%, 200%, 210%, 220%, 230%, 240%, 250%, 260%, 270%, 280%th, 290% or 300%.Relative to reference composition, strengthen the salinity of salt composite can improve at most 5%, 10%, 20%th, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 100%, 110%, 120%, 130%, 140%, 150%, 160%th, 170%, 180%, 190%, 200%, 210%, 220%, 230%, 240%, 250%, 260%, 270%, 280%th, 290% or 300%.Relative to reference composition, strengthen the salinity of salt composite can improve about 5%, 10%, 20%, 30%th, 40%, 50%, 60%, 70%, 80%, 90%, 100%, 110%, 120%, 130%, 140%, 150%, 160%, 170%th, 180%, 190%, 200%, 210%, 220%, 230%, 240%, 250%, 260%, 270%, 280%, 290% Or 300%.For example, relative to reference composition, salinity can improve 10-100%, 20-80% or 30-60%.
The delicate flavour or fragrance (umamior improved compared to reference composition can be had by strengthening salt composite savoriness).Preferably, reference composition is salt, rather than the reinforcing agent of the enhancing salt composite compared with it Compound.The delicate flavour or fragrance of the raising quantified can be had by strengthening salt composite.The delicate flavour or fragrance of the raising can be surveyed by sense organ Try to determine.This document describes the example of sense organ taste's test.
In some cases, relative to reference composition, strengthen the delicate flavour of salt composite or fragrance can improve at least 5%, 10%th, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 100%, 110%, 120%, 130%, 140%, 150%th, 160%, 170%, 180%, 190%, 200%, 210%, 220%, 230%, 240%, 250%, 260%, 270%th, 280%, 290% or 300%.Relative to reference composition, the delicate flavour or fragrance for strengthening salt composite can improve at most 5%th, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 100%, 110%, 120%, 130%, 140%th, 150%, 160%, 170%, 180%, 190%, 200%, 210%, 220%, 230%, 240%, 250%, 260%th, 270%, 280%, 290% or 300%.Relative to reference composition, the delicate flavour or fragrance for strengthening salt composite can carry It is high by about 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 100%, 110%, 120%, 130%, 140%th, 150%, 160%, 170%, 180%, 190%, 200%, 210%, 220%, 230%, 240%, 250%, 260%th, 270%, 280%, 290% or 300%.For example, relative to reference composition, delicate flavour or fragrance can improve 10- 100%th, 20-80% or 30-60%.In some cases, the enhancing salt composite that delicate flavour or fragrance improve includes glutamate (such as monosodium glutamate), guanosine hydrochlorate (such as Sodium guanylate) or inosinate (such as inosine acid disodium).In some feelings Under condition, the enhancing salt composite that delicate flavour or fragrance improve includes glycine.
In some cases, the salt strengthened in salt composite is sodium chloride.In some cases, strengthen in salt composite Enhancing immunomodulator compounds are glycine.In some cases, enhancing salt composite includes sodium chloride and glycine.In certain situation Under, the enhancing immunomodulator compounds strengthened in salt composite are silica.In some cases, enhancing salt composite includes sodium chloride And silica.In some cases, the enhancing immunomodulator compounds strengthened in salt composite are chitosan.In some cases, increase Strong salt composite includes sodium chloride and chitosan.In some cases, the enhancing immunomodulator compounds strengthened in salt composite are more for shell Sugar.In some cases, enhancing salt composite includes sodium chloride and chitin.In some cases, strengthen in salt composite Enhancing immunomodulator compounds are peptide.In some cases, enhancing salt composite includes sodium chloride and peptide.
The method for preparing enhancing salt composite
In an example, producing the method for enhancing salt composite includes mixing salt with enhancing immunomodulator compounds.Salt and increasing Strong immunomodulator compounds can while or add successively in any order.Salt and enhancing immunomodulator compounds may be dissolved in solvent or as solid Mixing.In some cases, the source of salt includes dissolving salt in a solvent, such as sauce (such as fish sauce, soy sauce, Italy Flour paste, catsup) or condiment.It can will strengthen immunomodulator compounds added to the source of salt.
The mixing can realize that this method includes stirring, homogenizing, sonication, grinds, pressure by one or more methods Contracting, blend, agitation, rotation mixing, using the solid-solid blend of static mixer, mortar and pestle, Kenics mixing, roller turns over Rolling and Turbula mixing.
During mixing, can adjust one or more response parameters, such as temperature, concentration, stoichiometry, order by merging, Mixing velocity and incorporation time.The intermolecular knot for the enhancing salt composite to be formed can be influenceed by adjusting one or more response parameters The degree of approach and/or particle diameter between structure, electrostatic interaction, total body density (bulkdensity), different component.
Enhancing salt composite can be formulated as solution.In some cases, in solvent the concentration of salt be about or at least 5%, 10%th, 15%, 20%, 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%th, 90%, 95% or 100%.In some cases, in solvent the concentration of salt be at most 5%, 10%, 15%, 20%, 25%th, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95% or 100%.In some cases, in solvent the concentration of salt be about 10-50%, 10-40%, 10-30%, 20-50%, 20-40%, 20-30% or 20-25%.In some cases, mix or dissolve in a solvent can 25 DEG C of highest, 30 DEG C, 35 DEG C, 40 DEG C, Carried out at a temperature of 45 DEG C, 50 DEG C, 55 DEG C, 60 DEG C, 65 DEG C, 70 DEG C, 75 DEG C, 80 DEG C, 85 DEG C, 90 DEG C, 95 DEG C or 100 DEG C. Under certain situation, mixing or dissolving can be carried out at room temperature in a solvent.
The pH of solution can be adjusted.In some cases, the pH of solution can be about or at least 2.0,2.1,2.2,2.3, 2.4、2.5、2.6、2.7、2.8、2.9、3.0、3.1、3.2、3.3、3.4、3.5、3.6、3.7、3.8、3.9、4.0、4.1、4.2、 4.3、4.4、4.5、4.6、4.7、4.8、4.9、5.0、5.1、5.2、5.3、5.4、5.5、5.6、5.7、5.8、5.9、6.0、6.1、 6.2、6.3、6.4、6.5、6.6、6.7、6.8、6.9、7.0、7.1、7.2、7.3、7.4、7.5、7.6、7.7、7.8、7.9、8.0、 8.1st, 8.2,8.3,8.4,8.5,8.6,8.7,8.8,8.9,9.0,9.1,9.2,9.3,9.4,9.5,9.6,9.7,9.8,9.9 or 10.0.In some cases, the pH of solution can be up to 2.0,2.1,2.2,2.3,2.4,2.5,2.6,2.7,2.8,2.9, 3.0、3.1、3.2、3.3、3.4、3.5、3.6、3.7、3.8、3.9、4.0、4.1、4.2、4.3、4.4、4.5、4.6、4.7、4.8、 4.9、5.0、5.1、5.2、5.3、5.4、5.5、5.6、5.7、5.8、5.9、6.0、6.1、6.2、6.3、6.4、6.5、6.6、6.7、 6.8、6.9、7.0、7.1、7.2、7.3、7.4、7.5、7.6、7.7、7.8、7.9、8.0、8.1、8.2、8.3、8.4、8.5、8.6、 8.7th, 8.8,8.9,9.0,9.1,9.2,9.3,9.4,9.5,9.6,9.7,9.8,9.9 or 10.0.In some cases, solution PH can be about 2.0-10.0,2.0-9.0,2.0-8.0,2.0-7.0,2.0-6.0,2.0-5.0,2.0-4.0,3.0-10.0, 4.0-10.0、5.0-10.0、6.0-10.0、7.0-10.0、8.0-10.0、9.0-10.0、3.0-9.0、4.0-9.0、5.0- 9.0、6.0-9.0、7.0-9.0、8.0-9.0、3.0-8.0、3.0-7.0、3.0-6.0、3.0-5.0、3.0-4.0、6.0-8.0、 6.0-7.0 or 7.0-8.0.
Preparing the method for enhancing salt composite preparation may include drying.In some cases, dry and formed doing and/or taken off The enhancing salt composite of water.In some cases, the enhancing salt composite for forming solid-state is dried.The non-limiting reality of drying means Example include crystallization, heat-force dry, evaporation, distill, boil, in stove heat, be dried in vacuo, spray drying, freeze-drying and freeze. Dry mechanism can influence to strengthen the aquation and molecular structure of salt composite, and produce the increasing with different physical properties Strong salt composite.In some cases, enhancing salt composite can dry to said composition include by weight at most 0.001%, 0.005%th, 0.01%, 0.05%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1.0%th, 1.5%, 2%, 2.5%, 3%, 3.5%, 4%, 4.5%, 5%, 6%, 7%, 8%, 9% or 10% water.One In the case of a little, enhancing salt composite can be dried to said composition and include by weight at least 0.001%, 0.005%, 0.01%, 0.05%th, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1.0%, 1.5%, 2%, 2.5%th, 3%, 3.5%, 4%, 4.5%, 5%, 6%, 7%, 8%, 9% or 10% water.In some cases, salt group is strengthened Compound can dry to said composition include by weight about 0.001%, 0.005%, 0.01%, 0.05%, 0.1%, 0.2%, 0.3%th, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1.0%, 1.5%, 2%, 2.5%, 3%, 3.5%, 4%th, 4.5%, 5%, 6%, 7%, 8%, 9% or 10% water.For example, enhancing salt composite can pass through any standard drying side Method (for example, the 12-80 hours in 60 DEG C of stove, use industrial air blower etc.) is dried to form dry solid enhancing salt combination Thing.
Preparing the method for enhancing salt composite may include mechanical mixture or grinding.Strengthen salt composite, salt and/or reinforcing agent Compound can be mixed or ground by one or more mechanical means.The non-limiting examples of mechanical means include stirring, Homogenizing, sonication, grind, compress, blend, agitation, rotation mixing, mixed using the solid-solid of static mixer, mortar and pestle Close, Kenics mixing, roller rolling and Turbula mixing.In some cases, the mechanical means of two or more forms can Serial or parallel connection uses.For example, enhancing salt composite can the mechanical lapping in grinder, and then further by mortar and grinding Pestle carries out mechanical lapping.The condition of machinery coating or grinding is (for example, temperature, duration, speed, opportunity, ratio, strength, pressure Power etc.) salinity of resulting composition can be influenceed.It can be chosen such that resulting composition obtains salinity at most to these conditions Lifting.In some cases, mix or grind may proceed to few 0.1,0.2,0.3,0.4,0.5,1,2,3,4,5,6,7,8,9, 10th, 11,12,13,14,15,16,17,18,19 or 20 minutes.In some cases, mixing or grinding can most be grown 0.1, 0.2nd, 0.3,0.4,0.5,1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 or 20 minute.One In the case of a little, mixing or grinding can carry out about 0.1,0.2,0.3,0.4,0.5,1,2,3,4,5,6,7,8,9,10,11,12,13, 14th, 15,16,17,18,19 or 20 minutes.In some cases, when the mechanical means serial or parallel connection of two or more forms In use, opportunity and the condition of every kind of form can be selected independently.
Preparing the method for enhancing salt composite may include sonication and/or homogenizing.Can to enhancing salt composite, salt and/or Strengthen immunomodulator compounds and carry out sonication and/or homogenizing.In some cases, sonication or homogenizing can most be grown 1,2,3,4,5, 6th, 7,8,9,10,11,12,13,14,15,16,17,18,19,20,24,30,40,50 or 60 minutes.In some cases, sound Processing or homogenizing may proceed to few 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,24,30, 40th, 50 or 60 minutes.In some cases, sonication or homogenizing can carry out about 1,2,3,4,5,6,7,8,9,10,11,12,13, 14th, 15,16,17,18,19,20,24,30,40,50 or 60 minutes.Sonication or homogenizing can be carried out together with heating.At some In the case of, sonication or homogenizing can be in highests 25,30,35,40,45,50,55,60,65,70,75,80,85,90,95 or 100 Carried out at a temperature of DEG C.In some cases, sonication or homogenizing can minimum 25,30,35,40,45,50,55,60,65, 70th, carry out at a temperature of 75,80,85,90,95 or 100 DEG C.In some cases, sonication or homogenizing can about 25,30,35, 40th, carry out at a temperature of 45,50,55,60,65,70,75,80,85,90,95 or 100 DEG C.In some cases, sonication or Homogenizing can be carried out at room temperature.In some cases, sonication can about or at least 5,6,7,8,9,10,11,12,13,14, 15th, carried out under 16,17,18,19,20,25,30,35,40,45,50,55,60,65,70,75 or 80kHz frequency.At some In the case of, sonication can be carried out in bath ultrasonoscope or using Probe Ultrasonic Searching ripple instrument.In some cases, homogenizing can be equal Change device, rotor-stator homogeniser, high-shear mixer (such as (inline) high shear in batch (-type) high-shear mixer, pipeline Powder inductor, high shear granulator, ultra-high shear inline mixer, high speed disperser, solid injection in blender, pipeline Device, high shear Rotor-stator mixers, tank mixer) in carry out.In some cases, sonication or homogenizing grinding or Carried out during mixing.In some cases, sonication and/or homogenizing are carried out to enhancing salt composite.In some cases, it is not right Strengthen salt composite and carry out sonication and/or homogenizing.
Preparing the method for enhancing salt composite may include to filter and/or sieves.Enhancing salt composite, salt and/or increasing can be made Strong immunomodulator compounds are by sieve or screening tower, and to remove specific dimensions from composition, at least minimum dimension is at most maximum Size, or at least minimum dimension and at most maximum sized particle.In some cases, sieve can have at most 30,40, 50th, the aperture mesh of 60,70,80,90,100,110,120,130,140,150,160,170,180,190 or 200 mesh.One In the case of a little, sieve can have at least 30,40,50,60,70,80,90,100,110,120,130,140,150,160,170, 180th, the aperture mesh of 190 or 200 mesh.In some cases, sieve can have about 30,40,50,60,70,80,90,100, 110th, the aperture mesh of 120,130,140,150,160,170,180,190 or 200 mesh.In some cases, sieve can have Possess the aperture mesh of about 40 to about 100 mesh.Sieve can have the aperture mesh of about 60 to about 70 mesh.
The application of salt composite
Provided herein is enhancing salt composite can be used as flavouring, flavoring or salt replacement products.Provided herein is enhancing salt Composition can be used as the flavouring or flavoring of edible product.Provided herein is enhancing salt composite can be used as edible product Salt replacement products.Edible product can include provided herein is composition.The non-limiting examples of edible product include food Product.
Prepare the edible product with salinity, relatively low salt content, relatively low sodium value or its any combination improved Method may include will strengthen salt composite added to edible product or with enhancing salt composite replacement edible product in one A part for kind or a variety of salt components.In some cases, edible product can include one or more and allow to be incorporated to enhancing salt The modified component of composition.
In some cases, enhancing salt composite as described herein can be added to or is substituted into (for example, can by replacing A part for one or more salt components in consumable products) in edible product, to produce at least 1,2,3,4 or 5 kind, at most 1st, 2,3,4 or 5 kind, or the characteristic that about 1,2,3,4 or 5 kind are selected from the group：The salinity of raising, kept while reducing salt used Saline taste sense, saline taste sense, the salt figure of reduction, and the sodium value of the edible product reduced are kept while reducing sodium used.Can By comprising enhancing salt composite edible product characteristic with not will strengthen salt composite be added to or be substituted into it is therein right It is compared according to product.For example, relative to reference product, there is addition or replacement the edible product for strengthening salt composite One or more characteristics can improve at least 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 100%th, 110%, 120%, 130%, 140%, 150%, 160%, 170%, 180%, 190%, 200%, 210%, 220%th, 230%, 240%, 250%, 260%, 270%, 280%, 290% or 300%.In some cases, relative to right According to product, one or more characteristics with the edible product of addition or replacement enhancing salt composite can improve at most 5%th, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 100%, 110%, 120%, 130%, 140%th, 150%, 160%, 170%, 180%, 190%, 200%, 210%, 220%, 230%, 240%, 250%, 260%th, 270%, 280%, 290% or 300%.In some cases, relative to reference product, have addition or replacement Strengthen one or more characteristics of the edible product of salt composite and can improve about 5%, 10%, 20%, 30%, 40%, 50%, 60%th, 70%, 80%, 90%, 100%, 110%, 120%, 130%, 140%, 150%, 160%, 170%, 180%, 190%th, 200%, 210%, 220%, 230%, 240%, 250%, 260%, 270%, 280%, 290% or 300%.Example Such as, 10-100%, 20-80% or 30-60% can be improved relative to reference product, salinity.
Sensory testing
The salinity improved can be determined by sensory testing.Can by sensory testing come determine have compared with lower salt content or compared with The equal salinity of low sodium value.The sensory testing can be flavor tests.The sensory testing can be Blind Test.For measuring what is improved One non-limiting examples of the flavor tests method of salinity then taste not same amount to taste a series of reference composition of amounts Enhancing salt composite, to find suitable with the salinity of the reference composition amount for strengthening salt composite.It can be calculated and carried by following formula High salinity：[amount of the enhancing salt composite required for the amount of reference composition-equal salinity]/[amount of reference composition]. For example, different amounts of enhancing salt composite as described herein is tasted (for example, 5,4,3,2 and 1mg's is sweet comprising sodium chloride and 1% The composition of propylhomoserin) with the discovery salinity equal with reference composition (for example, 5mg sodium chloride).In this case, if surveyed Examination shows that 3mg enhancing salt composite has the salinity equal with 5mg reference composition, then the salinity improved is calculated as (5- 3)/5=40%.
One or more different schemes can be used in sensory testing.For example, sensory testing can be " trigonometry ", follow ISO requirements or its combination.Flavor tests can be being averaged for test of many times.For example, each flavor tests person can taste it is a variety of Strengthen salt composite or food or include the edible product of enhancing salt composite, and they sort by relative salinity.Taste Test may include to taste reference material and determine whether test composition is more salty than reference material or be not as salty as reference material.
Flavor tests can be screening test, professional flavor tests or market survey test.Screening test can by least 1, 2nd, 3,4,5,6,7,8 or 9 flavor tests persons perform.Professional flavor tests can be surveyed by least 10,15,20,25 or 30 tastes Examination person performs.Market survey test can be by least 31,40,50,60,70,80,90,100,150,200,300,400 or 500 Flavor tests person performs.Flavor tests person can be the people with average taste perception.Flavor tests person can be that professional taste is surveyed Examination person.Flavor tests person can be the people for the trial test test for having already been through correct identification food or food component.Flavor tests Person can be the people of the relative quantity (for example, different amounts of sodium chloride in water is correctly ordered) of recognizable taste or flavor.
Embodiment
Embodiment 1：The enhancing salt composite for including glycine is formed from solid
By sodium chloride and glycine with amount listed in table 1, or by sodium chloride itself for tasting reference composition, Ground 20 seconds in Moulinex mills.By mixture mortar and the further mechanical lapping of pestle 10 minutes.By mixture With 40kHz sonications 30 minutes at 40 DEG C.Mixture is sieved with 200 microns.
Table 1
Embodiment 2：The trial test of enhancing salt composite comprising glycine
Give each taster 4mg every kind of sample.The results are shown in Table 2 for trial test based on saline taste sense.
Table 2
Symbol：X represents saline taste sense level, and X+1 represents the taste more salty than X, and X+1.5 represents the taste more salty than X+1, X+2 generations The table taste more salty than X+1.5
Embodiment 3：The trial test of enhancing salt composite comprising glycine
Give each taster 2mg every kind of sample.The results are shown in Table 3 for trial test based on saline taste sense.
Table 3
Symbol：X represents saline taste sense level, and X+0.5 represents the taste more salty than X, and X+1 represents the taste more salty than X+0.5, X+ 1.5 represent the taste more salty than X+1, and X+2 represents the taste more salty than X+1.5, and X+2.5 represents the taste more salty than X+2
Embodiment 4：The trial test of enhancing salt composite comprising glycine
Give each taster 2mg every kind of sample.The results are shown in Table 4 for trial test based on saline taste sense.
Table 4
Symbol：X represents saline taste sense level, and X+0.5 represents the taste more salty than X, and X+0.75 represents the taste more salty than X+0.5, X + 1 represents the taste more salty than X+0.75, and X+1.5 represents the taste more salty than X+1, and X+2 represents the taste more salty than X+1.5, X- 0.5 represents not as taste salty X
Embodiment 5：The trial test of enhancing salt composite comprising glycine
Give each taster 3mg every kind of sample.The results are shown in Table 5 for trial test based on saline taste sense.
Table 5
Symbol：X represents saline taste sense level, and X+0.5 represents the taste more salty than X, and X+0.75 represents the taste more salty than X+0.5, X + 1 represents the taste more salty than X+0.75, and X+1.5 represents the taste more salty than X+1, and X+2 represents the taste more salty than X+1.5, X+ 2.5 represent the taste more salty than X+2, and X-0.5 is represented not as taste salty X
Embodiment 6：The enhancing salt composite for including glycine is formed from solution
Sodium chloride is dissolved in formation 25%w/w sodium chloride solutions in deionized water.That is listed in addition table 6 is different amounts of sweet Propylhomoserin has the solution of the different glycine percentages relative to sodium chloride content to be formed.Solution is mixed 10 minutes.One In a little embodiments, sonication and/or homogenizing are further carried out to solution.
Table 6
Embodiment 7：The trial test of liquid enhancing salt composite comprising glycine
Each μ L of taster 15 every kind of sample is given, and 15 μ L 25% sodium chloride solution is used as control.Based on salty The results are shown in Table 7 for the trial test of sense of taste.
Table 7
Symbol：X represents saline taste sense level, and X+0.25 represents the taste more salty than X, and X+0.37 represents the taste more salty than X+0.25 Road, X+0.6 represent the taste more salty than X+0.37, and X+0.65 represents the taste more salty than X+0.6, and X+0.7, which is represented, compares X+0.65 More salty taste, X+1.5 represent the taste more salty than X+0.7
Embodiment 8：The trial test for the enhancing salt composite sample comprising glycine dried from solution
The fluid sample containing 25% sodium chloride and 0.25%, 2% or 3% glycine is dried, and relative to dry 25% sodium chloride solution is tasted as control.The results are shown in Table 8 for trial test based on saline taste sense.
Table 8
Symbol：X represents saline taste sense level, and X+0.15 represents the taste more salty than X, and X+0.3 represents the taste more salty than X+0.15, X+0.5 represents the taste more salty than X+0.3, and X+0.6 represents the taste more salty than X+0.5, and X+0.7 represents more salty than X+0.6 Taste
Embodiment 9：Wrap the formation of silica containing enhancing salt composite
Sodium chloride is dissolved in formation 20%w/w sodium chloride solutions in deionized water.Different amounts of two listed in addition table 9 Silica (such as Perkasil) with formed with relative to sodium chloride content different silica percentages Solution.Solution is vigorously mixed 1.5 hours.In some embodiments, solution is further carried out sonication and/or Change.
Table 9
Embodiment 10：Wrap the trial test of silica containing liquid enhancing salt composite
Each μ L of taster 15 every kind of sample is given, and 15 μ L 25% sodium chloride solution is used as control.Based on salty The results are shown in Table 10 for the trial test of sense of taste.
Table 10
Symbol：X represents saline taste sense level, and X+0.1 represents the taste more salty than X, and X+0.3 represents the taste more salty than X+0.1, X+ 0.6 represents the taste more salty than X+0.3, and X+0.7 represents the taste more salty than X+0.6, and X+0.9 represents the taste more salty than X+0.7 Road
Embodiment 11：Formed from solid and wrap silica containing enhancing salt composite
By sodium chloride and silica with relative to sodium chloride 0.1%, 0.25%, 0.5%, 1%, 2%, 3%, 3.5%, The silica of 5% or 8% w/w, or grind sodium chloride itself in Moulinex for tasting reference composition Ground 20 seconds in grinding machine.By mixture mortar and the further mechanical lapping of pestle 10 minutes.By mixture at 40 DEG C with 40kHz sonications 30 minutes.Mixture is sieved with 200 microns.
Embodiment 12：The enhancing salt composite for including chitosan is formed from solid
By sodium chloride and chitosan with relative to sodium chloride 0.1%, 0.25%, 0.5%, 1%, 2%, 3%, 3.5%, The chitosan of 5% or 10% w/w, or grind sodium chloride itself in Moulinex for tasting reference composition Ground 20 seconds in grinding machine.By mixture mortar and the further mechanical lapping of pestle 10 minutes.By mixture at 40 DEG C with 40kHz sonications 30 minutes.Mixture is sieved with 200 microns.
Embodiment 13：The enhancing salt composite for including chitosan is formed from solution
Sodium chloride is dissolved in formation 25%w/w sodium chloride solutions in deionized water.Different amounts of chitosan is added to be formed The shell for having 0.1%, 0.25%, 0.5%, 1%, 2%, 3%, 3.5%, 5% or 10% w/w relative to sodium chloride gathers The solution of sugar.Solution is mixed 10 minutes.In some embodiments, sonication and/or homogenizing are further carried out to solution. In some embodiments, solution is further dried to form dry enhancing salt composite.
Embodiment 14：The enhancing salt composite for including chitin is formed from solid
By sodium chloride and chitin with relative to sodium chloride 0.1%, 0.25%, 0.5%, 1%, 2%, 3%, 3.5%, The chitin of 5% or 10% w/w, or grind sodium chloride itself in Moulinex for tasting reference composition Ground 20 seconds in grinding machine.By mixture mortar and the further mechanical lapping of pestle 10 minutes.By mixture at 40 DEG C with 40kHz sonications 30 minutes.Mixture is sieved with 200 microns.
Embodiment 15：The enhancing salt composite for including chitin is formed from solution
Sodium chloride is dissolved in formation 25%w/w sodium chloride solutions in deionized water.Different amounts of chitin is added to be formed Have the shell of 0.1%, 0.25%, 0.5%, 1%, 2%, 3%, 3.5%, 5% or 10% w/w more relative to sodium chloride The solution of sugar.Solution is mixed 10 minutes.In some embodiments, sonication and/or homogenizing are further carried out to solution. In some embodiments, solution is further dried to form dry enhancing salt composite.
Embodiment 16：The enhancing salt composite for including peptide is formed from solid
By sodium chloride and Glu-Glu-Leu peptides with relative to sodium chloride 0.1%, 0.25%, 0.5%, 1%, 2%, 3%, 3.5%th, the Glu-Glu-Leu peptides of 5% or 10% w/w, or by sodium chloride itself for tasting reference composition, Ground 20 seconds in Moulinex grinders.By mixture mortar and the further mechanical lapping of pestle 10 minutes.By mixture With 40kHz sonications 30 minutes at 40 DEG C.Mixture is sieved with 200 microns.
Embodiment 17：The enhancing salt composite for including peptide is formed from solution
Sodium chloride is dissolved in formation 25%w/w sodium chloride solutions in deionized water.Add different amounts of Glu-Glu-Leu peptides There is 0.1%, 0.25%, 0.5%, 1%, 2%, 3%, 3.5%, 5% or 10% w/w relative to sodium chloride to be formed Glu-Glu-Leu peptides solution.Solution is mixed 10 minutes.In some embodiments, to solution further at carry out sound Reason and/or homogenizing.In some embodiments, solution is further dried to form dry enhancing salt composite.
Embodiment 18：The enhancing salt composite for including glycine is formed from soy sauce
Soy sauce is concentrated to form 25%w/w sodium chloride solutions.Different amounts of glycine is added to be formed relative to sodium chloride The solution of glycine with 0.1%, 0.25%, 0.5%, 1%, 2%, 3%, 3.5%, 5% or 10% w/w.Will Solution mixes 10 minutes.In some embodiments, sonication and/or homogenizing are further carried out to solution.In some embodiment party In case, solution is further dried to form dry enhancing salt composite.
Embodiment 19：The enhancing salt composite comprising glycine and potassium chloride is formed from solid
By potassium chloride and glycine with relative to potassium chloride 0.1%, 0.25%, 0.5%, 1%, 2%, 3%, 3.5%, The glycine of 5% or 10% w/w, or grind potassium chloride itself in Moulinex for tasting reference composition Ground 20 seconds in grinding machine.By mixture mortar and the further mechanical lapping of pestle 10 minutes.By mixture at 40 DEG C with 40kHz sonications 30 minutes.Mixture is sieved with 200 microns.
Embodiment 20：The enhancing salt composite comprising glycine and potassium chloride is formed from solution
Potassium chloride is dissolved in formation 25%w/w Klorvess Liquids in deionized water.Different amounts of glycine is added to be formed There is the sweet ammonia of 0.1%, 0.25%, 0.5%, 1%, 2%, 3%, 3.5%, 5% or 10% w/w relative to potassium chloride The solution of acid.Solution is mixed 10 minutes.In some embodiments, sonication and/or homogenizing are further carried out to solution. In some embodiments, solution is further dried to form dry enhancing salt composite.
Embodiment 21：The enhancing salt composite comprising glycine and Sodium guanylate is formed from solid
By Sodium guanylate and glycine with relative to Sodium guanylate 0.1%, 0.25%, 0.5%, 1%, 2%, 3%, 3.5%th, the glycine of 5% or 10% w/w, or by Sodium guanylate itself for tasting reference composition, Ground 20 seconds in Moulinex grinders.By mixture mortar and the further mechanical lapping of pestle 10 minutes.Mixture is existed With 40kHz sonications 30 minutes at 40 DEG C.Mixture is sieved with 200 microns.
Embodiment 22：The enhancing salt composite comprising glycine and Sodium guanylate is formed from solution
Sodium guanylate is dissolved in formation 25%w/w Sodium guanylate solution in deionized water.Add different amounts of sweet ammonia Acid has 0.1%, 0.25%, 0.5%, 1%, 2%, 3%, 3.5%, 5% or 10% weight to be formed relative to Sodium guanylate The solution of the glycine of amount/weight.Solution is mixed 10 minutes.In some embodiments, to solution further at carry out sound Reason and/or homogenizing.In some embodiments, solution is further dried to form dry enhancing salt composite.
Embodiment 23：The enhancing salt composite comprising glycine and inosine acid disodium is formed from solid
By inosine acid disodium and glycine with relative to inosine acid disodium 0.1%, 0.25%, 0.5%, 1%, 2%, 3%, 3.5%th, the glycine of 5% or 10% w/w, or by inosine acid disodium itself for tasting reference composition, Ground 20 seconds in Moulinex grinders.By mixture mortar and the further mechanical lapping of pestle 10 minutes.Mixture is existed With 40kHz sonications 30 minutes at 40 DEG C.Mixture is sieved with 200 microns.
Embodiment 24：The enhancing salt composite comprising glycine and inosine acid disodium is formed from solution
Sodium guanylate is dissolved in formation 25%w/w inosine acid disodium solution in deionized water.Add different amounts of sweet ammonia Acid has 0.1%, 0.25%, 0.5%, 1%, 2%, 3%, 3.5%, 5% or 10% weight to be formed relative to inosine acid disodium The solution of the glycine of amount/weight.Solution is mixed 10 minutes.In some embodiments, to solution further at carry out sound Reason and/or homogenizing.In some embodiments, solution is further dried to form dry enhancing salt composite.
Embodiment 25：Enhancing salt composite is used in soup
Liquid vegetable reserve is divided into four samples, each volume with 100mL.To the addition of each sample it is following it One：
A) sodium chloride solutions of 1.48g 25% (0.37g sodium chloride) are to form sample A
B) sodium chloride solutions of 1.48g 25% (~0.37g strengthen salt composite) with 3% glycine are to form sample B
Sample is stirred 10 minutes, then tasted.The results are shown in Table 11 for trial test based on saline taste sense.
Table 11
Sample A- is compareed Sample B
Taster 1 X It is more salty
Taster 2 X It is more salty
Taster 3 X It is identical with control
Embodiment 26：Sensory testing's program
The test is participated in by the one group of flavor tests for having already passed through sensory testing in the past person.All participants have been subjected to instruction Practice.The test is divided into following 3 parts：
A) sense limen of taster is tested
B) calibrate
C) sodium chloride reference composition is tasted with enhancing salt composite
Sense limen：Three reference samples of group's participant's reference composition are given, it is by 4mg, 3mg and 2mg solid Sodium chloride forms.Participant reports the saline taste sense of various reference composition samples.
Calibration steps：The step is to test this group of personnel to the another of the sense limen of salinity and the ability of identification slight change A kind of form is added to during trial test.Give 5mg, 4mg and 2mg solid sodium chloride that group member indicates " A ", " B " and " C " Reference composition sample.
Trial test process：The trial test stage in addition to calibration is entered in the form of tasting reference composition and enhancing salt composite OK.Give each participant's reference composition sample and enhancing salt composite sample.Reference composition sample is labeled as " control "； Strengthen salt composite sample random digit label.Instruction participant is classified with reference to reference composition to saline taste sense.If If needing, the extra reference composition sample of participant is given.
Taste every time and give two groups of tests of participant.Two groups comprising a reference composition sample and an enhancing salt group Compound sample.Remaining test is similarly carried out, is tested in two groups of tests using sodium chloride reference composition as object of reference Each sample.
Although the preferred embodiment of present disclosure has been shown and described herein, for people in the art Member is it is readily apparent that these embodiments only provide in an illustrative manner.Those skilled in the art are not being departed from the disclosure A variety of changes are will now occur in the case of appearance, changes and substitutes.It should be appreciated that embodiment of the present invention specifically described herein is each Kind alternative solution can be used for implementing present disclosure.Purpose be with the claims below limit scope of the present disclosure, and Thus the method and structure and its equivalent in these rights are covered.

Claims (20)

1. a kind of method for producing enhancing salt composite, it includes mixing salt with enhancing immunomodulator compounds is combined with producing enhancing salt Thing；Wherein compared with reference composition, the enhancing salt composite has the salinity improved；And wherein described reference composition By being formed in species and amount with the enhancing salt composite identical inclusion, but be free of the enhancing immunomodulator compounds.
2. according to the method for claim 1, further comprise that dissolve the salt and the enhancing immunomodulator compounds increases to produce Strong salt composite solution.
3. according to the method for claim 2, further comprise that the pH for adjusting the enhancing salt composite solution is horizontal.
4. according to the method any one of claim 1-3, further comprise drying the enhancing salt composite or make institute State enhancing salt composite sieving.
5. according to the method any one of claim 1-4, further comprise sonication or the homogenizing enhancing salt combination Thing.
6. according to the method any one of claim 1-5, wherein the salt is sodium chloride.
7. according to the method any one of claim 1-6, wherein the reinforcing agent compound is selected from amino acid, peptide, egg White matter, metal oxide, chitosan, chitin and its any combination.
8. according to the method for claim 7, wherein the amino acid is selected from alanine, arginine, asparagine, asparagus fern ammonia Acid, cysteine, glutamic acid, glutamine, glycine, histidine, isoleucine, leucine, lysine, methionine, benzene Alanine, proline, serine, threonine, tryptophan, tyrosine, valine, selenocysteine, pyrrolysine and its Any combination.
9. according to the method for claim 7, wherein the peptide is selected from dipeptides, tripeptides, tetrapeptide, pentapeptide and its any combination.
10. according to the method any one of claim 1-9, wherein the enhancing salt composite is included relative to salt at most The enhancing immunomodulator compounds of about 10% w/w.
11. according to the method any one of claim 1-10, wherein the salinity improves at least 10%, 20%, 30%, 40% or 50%.
A kind of 12. enhancing salt composite comprising salt and enhancing immunomodulator compounds；Wherein it is described enhancing salt composite have relative to The enhancing immunomodulator compounds of salt at most about 10% w/w；Wherein described enhancing salt composite has compared to reference composition The salinity of raising；And wherein described reference composition with described in species and amount by strengthening salt composite identical inclusion Composition, but be free of the enhancing immunomodulator compounds.
13. enhancing salt composite according to claim 12, wherein the salt is sodium chloride.
14. the enhancing salt composite according to any one of claim 12-13, wherein the reinforcing agent compound is selected from ammonia Base acid, peptide, protein, metal oxide, chitosan, chitin and its any combination.
15. enhancing salt composite according to claim 14, wherein the amino acid is selected from alanine, arginine, asparagus fern Acid amides, aspartic acid, cysteine, glutamic acid, glutamine, glycine, histidine, isoleucine, leucine, lysine, Methionine, phenylalanine, proline, serine, threonine, tryptophan, tyrosine, valine, selenocysteine, pyrroles Lysine and its any combination.
16. enhancing salt composite according to claim 14, wherein the peptide be selected from dipeptides, tripeptides, tetrapeptide, pentapeptide and its Any combination.
17. the enhancing salt composite according to any one of claim 12-16, wherein salinity raising at least 10%, 20%th, 30%, 40% or 50%.
18. a kind of composition comprising food or edible product, it includes the enhancing any one of claim 12-17 Salt composite.
19. composition according to claim 18, wherein the food or edible product are selected from and bakee thing, seasoning, sauce Material, condiment, meat, meat processing, hamburger, egg, vegetables, cereal, pie, Custard cake, pasta, meat alternative, beans Corruption, peanut, nut, seed, snacks, cheese, spices, soup, dairy products and its any combination.
20. a kind of method for making food or edible product, it is included with the enhancing any one of claim 12-17 Salt composite substitutes at least a portion of salt component.
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