CN107837205A - The preparation method of skin repair facial mask - Google Patents
The preparation method of skin repair facial mask Download PDFInfo
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- CN107837205A CN107837205A CN201711216628.5A CN201711216628A CN107837205A CN 107837205 A CN107837205 A CN 107837205A CN 201711216628 A CN201711216628 A CN 201711216628A CN 107837205 A CN107837205 A CN 107837205A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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Abstract
A kind of preparation method of skin repair facial mask, 5 100 g pyrrolidone sodium carboxylates and 5 100 g 2-pyrrolidone-5-carboxylic acid's copper dissolutions, 5 100 g octadecyl alcolols of addition and 5 80g isopropyl myristates are dissolved with 200 400g pure water, obtain the first solution；0.1 5 g preservatives are dissolved with the 110g of pure water 90, obtain the second solution；0.004 0.2 g metallothioneins and 0.002 0.04 g recombinant human epidermal growth factors are dissolved with 200 400g pure water, add 0.02 5g OPCs, 0.01 5g vitamin Cs and the dissolving of 0.01 4 g vitamin Es, 0.02 5 g allantoins and the dissolving of 0.04 6 g Seabuckthorm Seed Oils are added, obtain the 3rd solution；First, second, and third solution is mixed, obtains mixed liquor；Mixed liquor is sprayed to non-woven fabrics, controls the liquid holdup of non-woven fabrics, cuts and pack and to obtain finished product.
Description
Technical field
The invention belongs to skin repair and skin care articles for use preparing technical field, and in particular to a kind of skin repair facial mask
Preparation method.
Background technology
Skin is the maximum organ of people's bulk area.It makes various in vivo organize with organ from physical, mechanicalness, chemistry
The invasion and attack of property and pathogenic microorganism.Skin has the barrier action of two aspects：When prevent moisture in vivo, electrolyte, its
He loses material；Second, prevent the intrusion of extraneous harmful substance.Skin remains the stabilization of human internal environment, while skin is also joined
With the metabolic process of human body.
With the development of society, various surface of a wound problems more and more frequently show.According to statistics, there is about l% population in the whole world
Perplexed by the surface of a wound problem of continuation, about 5% medical expense is spent in wound repair.The especially chronic refractory of the surface of a wound
The surface of a wound incidence of disease is in increase trend year by year.In the U.S., the annual expense for chronic wound treatment is expected up to 8,000,000,000 dollars
It will be increased with annual 10% speed.In China, chronic wound patient is just up to 40,000,000 only caused by diabetes according to statistics, every year
Only burn patient just has the people of 500-1000 ten thousand.Only a few peoples' surface of a wound is easy to heal, and most people's impaired wound healing closes or formed tight
Weight scar, has a strong impact on quality of life.
Numerous researchs show, oxygen radical, the part of lipid peroxidation and burnt degree involvement and away from each device of burned part
The pathological development of official and tissue is closely related.Due to burned part oxygen radical and its peroxidatic reaction of lipid of startup, make silt
Stagnant band expands, and the effect of body Free-radical ring opening polymerization reduces while lipid peroxidation strengthens, and the local lipid mistake of burn
The systemic Absorption of oxidation product can also influence on the functional bands of body organa parenchymatosum.
It is no lack of the technical information on skin repair composition and its preparation in disclosed Chinese patent literature, such as
CN1711095B（Damage skin repair composition）、CN1772288A（A kind of Recipe of skin repairing composition）、
CN102639139B（Composition and method for skin repair）、CN103550117A（Skin repair and regeneration can be promoted
Cosmetics and skincare product and its preparation method and application）、CN104739710B（A kind of skin repair compound and application thereof）、
CN105147534A（A kind of peptide composition for skin repair）、CN105326684A（A kind of skin repair liquid and its should
With）、CN106309204A（A kind of composition for skin repair）、CN106266084A（Skin repair composition and its system
Preparation Method and application method）、CN106365130A（A kind of composition for skin repair and preparation method thereof）、
CN106265479A（A kind of skin repair composition and preparation method thereof）And CN106963660A（A kind of skin repair insulation group
Compound and its application in cosmetics are prepared）, etc..
As is known in the industry, accelerate wound epithelialization speed and promote the maturation of wound surface；Ensure that epidermal cell is quickly advised
Then growth and timely flap coverage；Accelerate tissue maintenance and increase skin elasticity；Suppress esterified ferment release；Protect lipid not by
Oxidation；Improve anti-stress ability and immunity of the human body to external environment；Melanin generation, etc. is reduced, is to consider skin to repair
Multiple effect and an important factor for reduce scar, but be not limited to above mentioned patent formula and be not enough to comprehensive embody this
A little factors, technical scheme described below are caused under this background.
The content of the invention
The task of the present invention is to provide a kind of preparation method of skin repair facial mask, and this method preparation technology is simple and obtains
With the skin repair facial mask for meeting industrial amplification production requirement and being obtained by this method, wound epithelialization speed is helped speed up
Spend and promote the maturation of wound surface, be advantageous to ensure epidermal cell quick and growth regularity and timely flap coverage, be beneficial to
Accelerate tissue maintenance and promote skin elasticity, have and be easy to suppress esterified ferment release, help to protect lipid not oxidized, favourable
In improve human body to the anti-stress ability and immunity of external environment, be beneficial to reduce melanin generation and reduce skin wrinkle
Line.
What the task of the present invention was performed by, a kind of preparation method of skin repair facial mask, comprise the following steps：
A）The first solution is prepared, with 200-400g pure water by 5-100 g pyrrolidone sodium carboxylates and 5-100 g 2-pyrrolidone-5-carboxylic acids
Copper dissolves under stirring, adds 5-100 g octadecyl alcolols and 5-80 g isopropyl myristates continue stirring to dissolving, obtain
It is stand-by to the first solution；
B）The second solution is prepared, 0.1-5 g preservatives are dissolved under stirring with pure water 90-110g, obtain the second solution,
It is stand-by；
C）The 3rd solution is prepared, with 200-400g pure water by 0.004-0.2 g metallothioneins and 0.002-0.04 g recombined humans
EGF dissolves under stirring, adds 0.02-5 g OPCs, 0.01-5g vitamin Cs and 0.01-4 g
Vitamin E is stirred to dissolving, adds 0.02-5 g allantoins and 0.04-6 g Seabuckthorm Seed Oils continue stirring to dissolving, and obtains the
Three solution, it is stand-by；
D）Mixed liquor is prepared, first will be respectively by step A）、B）And C）Obtained the first solution, the second solution and the 3rd solution mixes
Close, then it is filtered, obtain mixed liquor；
E）Finished product is prepared, will be by step D）Obtained mixed liquor is sprayed to non-woven fabrics, and controls the liquid holdup of non-woven fabrics, then passes through
Cutting and packaging, obtain skin repair facial mask.
The present invention a specific embodiment in, described metallothionein be vigor be 5000-30000 units/
The mL α fragments of metallothionein III.
In another specific embodiment of the present invention, described preservative is methyl p-hydroxybenzoate or is two
Methylol dimethyl hydantion and the iodo- 2-propynyl butyl carbamate mixtures of 3-（DMDMH Plus）.
In another specific embodiment of the present invention, the vigor of described recombinant human epidermal growth factor is 0.2-5
Million international units/mL.
The present invention another specific embodiment in, described pure water be purity be 0.1-0.16 μm/cm go from
Sub- water or distilled water.
The present invention also have a specific embodiment in, described cutting be by non-woven fabrics cut into 18 × 20cm~
20 × 24cm specification.
In a still more specific embodiment of the invention, the grammes per square metre of the non-woven fabrics is 500-800g/ ㎡.
The present invention's and then in a specific embodiment, the liquid holdup of described control non-woven fabrics is by liquid holdup control
It is made as the 200-300% of non-woven weight.
One of technique effect of technical scheme provided by the invention, because preparation technology is terse, thus industrialization can be met
Amplify production requirement；Two, due to introducing metallothionein in formula, and because metallothionein is low molecule amount containing more
The non-zymoprotein of coloured glaze base and divalent metal, there is obvious removing free radical and protection biomembrane function, be reduced on the surface of a wound
The time of skin；Three, due to introducing 2-pyrrolidone-5-carboxylic acid's copper in formula, and because 2-pyrrolidone-5-carboxylic acid's copper is a kind of super
Powerful antioxidant, it is 40 times of common L-AA antioxygenic property, thus is advantageous to stimulation collagen in skin
Synthesis, manufacture elastomer, accelerate the maintenance of tissue, increase the elasticity of skin, embodying the preferable recovery effects of wound skin；
Four, due to introducing recombinant human epidermal growth factor in formula, epidermis is irritated by being combined with EGF-R ELISA
Cell（Including endothelial cell, keratinocyte, fibroblast）Into CDC, it is in wire to promote collagenous fibres
Arrangement, the growth of epidermal cell fast regular and timely flap coverage；Five, due to introduced in formula OPC, dimension life
Plain C and vitamin E, it both can also coordinate that metallothionein is anti-oxidant with independent antioxidation, and reduce melanin
Generation and reduction wrinkle of skin.
Embodiment
Embodiment 1：
A）The first solution is prepared, is being stirred 25 g pyrrolidone sodium carboxylates and 40 g 2-pyrrolidone-5-carboxylic acids copper with 200 g pure water
Dissolved under state, add 20g octadecyl alcolols and 50 g isopropyl myristates continue stirring to dissolving, obtain the first solution, treat
With；
B）The second solution is prepared, 0.1 g methyl p-hydroxybenzoates are dissolved under stirring with 90g pure water, obtain second
Solution, it is stand-by；
C）The 3rd solution is prepared, is being stirred 0.1g metallothioneins and 0.002g recombinant human epidermal growth factors with 300g pure water
Dissolved under state, add 3g OPCs, 0.01g vitamin Cs and 3g vitamin Es and stir to dissolving, add 0.09 g urine
Bursin and 6 g Seabuckthorm Seed Oils continue stirring to dissolving, and obtain the 3rd solution, stand-by；
D）Mixed liquor is prepared, first will be by step A）Obtained the first solution, by step B）Obtained the second solution and by step
C）Obtained the 3rd solution mixing, then it is filtered, obtain mixed liquor；
E）Finished product is prepared, will be by step D）It is 500g/ ㎡ non-woven fabrics that obtained mixed liquor, which is sprayed to grammes per square metre, the liquid holdup of non-woven fabrics
Control as the 200% of non-woven weight, i.e., the liquid content of non-woven fabrics is 2 times of non-woven weight, and spraying has the non-woven fabrics of mixed liquor
Just as the state of the moisture paper tissue papers seen in daily life, then cut into 18 × 21cm specification and packed, obtain skin
Repair facial mask.
Metallothionein described in the present embodiment is the α fragments of metallothionein III that vigor is 5000-30000 units/mL,
The α fragments of metallothionein III preferably rather than definitely be limited to use by the limited public affairs of Jiangsu Province, China Suzhou City tip biological products
The trade mark that department produces and in market public offering before the application proposition is the metallothioneins of XD-O- II；The present embodiment
The vigor of described recombinant human epidermal growth factor is 0.2-5 million international units/mL, and recombinant human epidermal growth factor, which has, to be repaired
Wound, prevention color spot, smooth away wrinkles and also have the function that well tender skin and skin care；Described pure water is that purity is
0.1-0.16 μm/cm deionized water, but the distilled water that purity is 0.1-0.16 μm/cm can also be used.
Embodiment 2：
A）The first solution is prepared, with 320 g pure water by 40 g pyrrolidone sodium carboxylates and 20g 2-pyrrolidone-5-carboxylic acids copper in stirring shape
Dissolved under state, add 5g octadecyl alcolols and 80 g isopropyl myristates continue stirring to dissolving, obtain the first solution, it is stand-by；
B）The second solution is prepared, 1g methyl p-hydroxybenzoates are dissolved under stirring with 110g pure water, it is molten to obtain second
Liquid, it is stand-by；
C）The 3rd solution is prepared, is being stirred 0.004g metallothioneins and 0.005g recombinant human epidermal growth factors with 200g pure water
Mix and dissolved under state, add 5g OPCs, 0.09g vitamin Cs and 4g vitamin Es and stir to dissolving, add 5g allantois
Element and 0.04g Seabuckthorm Seed Oils continue stirring to dissolving, and obtain the 3rd solution, stand-by；
D）Mixed liquor is prepared, first will be by step A）Obtained the first solution, by step B）Obtained the second solution and by step
C）Obtained the 3rd solution mixing, then it is filtered, obtain mixed liquor；
E）Finished product is prepared, will be by step D）It is 600g/ ㎡ non-woven fabrics that obtained mixed liquor, which is sprayed to grammes per square metre, the liquid holdup of non-woven fabrics
Control as the 300% of non-woven weight, i.e., the liquid content of non-woven fabrics is 3 times of non-woven weight, and spraying has the non-woven fabrics of mixed liquor
Just as the state of the moisture paper tissue papers seen in daily life, then cut into 19 × 20cm specification and packed, obtain skin
Repair facial mask.Remaining is the same as the description to embodiment 1.
Embodiment 3：
A）The first solution is prepared, with 250 g pure water by 80g pyrrolidone sodium carboxylates and 50 g 2-pyrrolidone-5-carboxylic acids copper in stirring shape
Dissolved under state, add 100g octadecyl alcolols and 5 g isopropyl myristates continue stirring to dissolving, obtain the first solution, it is stand-by；
B）The second solution is prepared, 5 g methyl p-hydroxybenzoates are dissolved under stirring with 105g pure water, it is molten to obtain second
Liquid, it is stand-by；
C）The 3rd solution is prepared, is being stirred 0.008g metallothioneins and 0.008g recombinant human epidermal growth factors with 400g pure water
Mix and dissolved under state, add 0.02g OPCs, 1.5g vitamin Cs and 1.5g vitamin Es and stir to dissolving, add 3 g
Allantoin and 0.1 g Seabuckthorm Seed Oils continue stirring to dissolving, and obtain the 3rd solution, stand-by；
D）Mixed liquor is prepared, first will be by step A）Obtained the first solution, by step B）Obtained the second solution and by step
C）Obtained the 3rd solution mixing, then it is filtered, obtain mixed liquor；
E）Finished product is prepared, will be by step D）It is 650g/ ㎡ non-woven fabrics that obtained mixed liquor, which is sprayed to grammes per square metre, the liquid holdup of non-woven fabrics
Control as the 250% of non-woven weight, i.e., the liquid content of non-woven fabrics is 2.5 times of non-woven weight, and spraying has the nonwoven of mixed liquor
Cloth is just as the state of the moisture paper tissue papers seen in daily life, then cuts into 18 × 24cm specification and packed, and obtains skin
Skin repairs facial mask.Remaining is the same as the description to embodiment 1.
Embodiment 4：
A）The first solution is prepared, with 100 g pure water by 5g pyrrolidone sodium carboxylates and 60 g 2-pyrrolidone-5-carboxylic acids copper in stirring shape
Dissolved under state, add 40g octadecyl alcolols and 40 g isopropyl myristates continue stirring to dissolving, obtain the first solution, it is stand-by；
B）The second solution is prepared, 4g methyl p-hydroxybenzoates are dissolved under stirring with 100g pure water, it is molten to obtain second
Liquid, it is stand-by；
C）The 3rd solution is prepared, is being stirred 0.2g metallothioneins and 0.01g recombinant human epidermal growth factors with 250g pure water
Dissolved under state, add 0.1g OPCs, 2.5g vitamin Cs and 0.01g vitamin Es and stir to dissolving, add 1 g urine
Bursin and 2g Seabuckthorm Seed Oils continue stirring to dissolving, and obtain the 3rd solution, stand-by；
D）Mixed liquor is prepared, first will be by step A）Obtained the first solution, by step B）Obtained the second solution and by step
C）Obtained the 3rd solution mixing, then it is filtered, obtain mixed liquor；
E）Finished product is prepared, will be by step D）It is 700g/ ㎡ non-woven fabrics that obtained mixed liquor, which is sprayed to grammes per square metre, the liquid holdup of non-woven fabrics
Control as the 280% of non-woven weight, i.e., the liquid content of non-woven fabrics is 2.8 times of non-woven weight, and spraying has the nonwoven of mixed liquor
Cloth is just as the state of the moisture paper tissue papers seen in daily life, then cuts into 18 × 23cm specification and packed, and obtains skin
Skin repairs facial mask.Remaining is the same as the description to embodiment 1.
Embodiment 5：
A）The first solution is prepared, with 150 g pure water by 60g pyrrolidone sodium carboxylates and 80 g 2-pyrrolidone-5-carboxylic acids copper in stirring shape
Dissolved under state, add 80g octadecyl alcolols and 25g isopropyl myristates continue stirring to dissolving, obtain the first solution, it is stand-by；
B）The second solution is prepared, 3 g methyl p-hydroxybenzoates are dissolved under stirring with 95g pure water, it is molten to obtain second
Liquid, it is stand-by；
C）The 3rd solution is prepared, is being stirred 0.12g metallothioneins and 0.04g recombinant human epidermal growth factors with 350g pure water
Dissolved under state, add 1g OPCs, 5g vitamin Cs and 0.07g vitamin Es and stir to dissolving, add 0.02g allantois
Element and 3.5g Seabuckthorm Seed Oils continue stirring to dissolving, and obtain the 3rd solution, stand-by；
D）Mixed liquor is prepared, first will be by step A）Obtained the first solution, by step B）Obtained the second solution and by step
C）Obtained the 3rd solution mixing, then it is filtered, obtain mixed liquor；
E）Finished product is prepared, will be by step D）It is 800g/ ㎡ non-woven fabrics that obtained mixed liquor, which is sprayed to grammes per square metre, the liquid holdup of non-woven fabrics
Control as the 220% of non-woven weight, i.e., the liquid content of non-woven fabrics is 2.2 times of non-woven weight, and spraying has the nonwoven of mixed liquor
Cloth is just as the state of the moisture paper tissue papers seen in daily life, then cuts into 20 × 20cm specification and packed, and obtains skin
Skin repairs facial mask.Remaining is the same as the description to embodiment 1.
Embodiment 6：
A）The first solution is prepared, with 400 g pure water by 100g pyrrolidone sodium carboxylates and 5g 2-pyrrolidone-5-carboxylic acids copper in stirring shape
Dissolved under state, add 50g octadecyl alcolols and 65 g isopropyl myristates continue stirring to dissolving, obtain the first solution, it is stand-by；
B）The second solution is prepared, with 98g pure water by 2g dimethyloldimethylhydantoins and the iodo- 2-propynyl carbamic acids of 3-
Butyl ester is dissolved by mixture of the same volume than mixing under stirring, obtains the second solution, stand-by；
C）The 3rd solution is prepared, is being stirred 0.16g metallothioneins and 0.03g recombinant human epidermal growth factors with 280g pure water
Dissolved under state, add 4g OPCs, 3.5g vitamin Cs and 1g vitamin Es and stir to dissolving, add 2 g allantoins
Continue stirring to dissolving with 4.5 g Seabuckthorm Seed Oils, obtain the 3rd solution, it is stand-by；
D）Mixed liquor is prepared, first will be by step A）Obtained the first solution, by step B）Obtained the second solution and by step
C）Obtained the 3rd solution mixing, then it is filtered, obtain mixed liquor；
E）Finished product is prepared, will be by step D）It is 550g/ ㎡ non-woven fabrics that obtained mixed liquor, which is sprayed to grammes per square metre, the liquid holdup of non-woven fabrics
Control as the 265% of non-woven weight, i.e., the liquid content of non-woven fabrics is 2.65 times of non-woven weight, and spraying has the nothing of mixed liquor
Cloth is spun in moisture state i.e. in the state of the moisture paper tissue papers seen in daily life, then cut into 20 × 22cm specification and progress
Packaging, obtains skin repair facial mask.Remaining is the same as the description to embodiment 1.
The skin repair facial mask obtained using the present embodiment, takes one piece daily, spreads at damaged skin or wrinkle and protects
Hold 30-90min.
Claims (8)
1. a kind of preparation method of skin repair facial mask, it is characterised in that comprise the following steps：
A）The first solution is prepared, with 200-400g pure water by 5-100 g pyrrolidone sodium carboxylates and 5-100 g 2-pyrrolidone-5-carboxylic acids
Copper dissolves under stirring, adds 5-100 g octadecyl alcolols and 5-80 g isopropyl myristates continue stirring to dissolving, obtain
It is stand-by to the first solution；
B）The second solution is prepared, 0.1-5 g preservatives are dissolved under stirring with pure water 90-110g, obtain the second solution,
It is stand-by；
C）The 3rd solution is prepared, with 200-400g pure water by 0.004-0.2 g metallothioneins and 0.002-0.04 g recombined humans
EGF dissolves under stirring, adds 0.02-5 g OPCs, 0.01-5g vitamin Cs and 0.01-4 g
Vitamin E is stirred to dissolving, adds 0.02-5 g allantoins and 0.04-6 g Seabuckthorm Seed Oils continue stirring to dissolving, and obtains the
Three solution, it is stand-by；
D）Mixed liquor is prepared, first will be respectively by step A）、B）And C）Obtained the first solution, the second solution and the 3rd solution mixes
Close, then it is filtered, obtain mixed liquor；
E）Finished product is prepared, will be by step D）Obtained mixed liquor is sprayed to non-woven fabrics, and controls the liquid holdup of non-woven fabrics, then passes through
Cutting and packaging, obtain skin repair facial mask.
A kind of 2. preparation method of skin repair facial mask according to claim 1, it is characterised in that described metallothionein
White is the α fragments of metallothionein III that vigor is 5000-30000 units/mL.
3. the preparation method of a kind of skin repair facial mask according to claim 1, it is characterised in that described preservative is
Methyl p-hydroxybenzoate mixes for dimethyloldimethylhydantoin with the iodo- 2-propynyl butyl carbamates of 3-
Thing.
A kind of 4. preparation method of skin repair facial mask according to claim 1, it is characterised in that described recombined human table
The vigor of skin growth factor is 0.2-5 million international units/mL.
5. the preparation method of a kind of skin repair facial mask according to claim 1, it is characterised in that described pure water is pure
Spend the deionized water or distilled water for 0.1-0.16 μm/cm.
A kind of 6. preparation method of skin repair facial mask according to claim 1, it is characterised in that described cutting be by
Non-woven fabrics cuts into 18 × 20cm~20 × 24cm specification.
7. the preparation method of a kind of skin repair facial mask according to claim 1 or 6, it is characterised in that the non-woven fabrics
Grammes per square metre is 500-800g/ ㎡.
A kind of 8. preparation method of skin repair facial mask according to claim 1, it is characterised in that described control nonwoven
The liquid holdup of cloth is the 200-300% for non-woven weight by liquid holdup control.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711216628.5A CN107837205A (en) | 2017-11-28 | 2017-11-28 | The preparation method of skin repair facial mask |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711216628.5A CN107837205A (en) | 2017-11-28 | 2017-11-28 | The preparation method of skin repair facial mask |
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| Publication Number | Publication Date |
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| CN107837205A true CN107837205A (en) | 2018-03-27 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201711216628.5A Pending CN107837205A (en) | 2017-11-28 | 2017-11-28 | The preparation method of skin repair facial mask |
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| CN (1) | CN107837205A (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101073539A (en) * | 2006-05-19 | 2007-11-21 | 湖南麓谷生物技术有限公司 | Skin-moistening composition containing metal sulfur protein for improving acne repair |
| CN104666114A (en) * | 2015-03-10 | 2015-06-03 | 成都舒乐科技发展有限公司 | Wrinkle removing, anti-aging, skin activating and scar fading repair essence and preparation method thereof |
-
2017
- 2017-11-28 CN CN201711216628.5A patent/CN107837205A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101073539A (en) * | 2006-05-19 | 2007-11-21 | 湖南麓谷生物技术有限公司 | Skin-moistening composition containing metal sulfur protein for improving acne repair |
| CN104666114A (en) * | 2015-03-10 | 2015-06-03 | 成都舒乐科技发展有限公司 | Wrinkle removing, anti-aging, skin activating and scar fading repair essence and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 成都阿尔法生物科技有限公司: "《www.a-biotech.com/gsxw/261.html》", 25 May 2017 * |
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