CN107831184A - 一种x射线荧光分析鉴别真伪朱砂的方法 - Google Patents

一种x射线荧光分析鉴别真伪朱砂的方法 Download PDF

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CN107831184A
CN107831184A CN201711364437.3A CN201711364437A CN107831184A CN 107831184 A CN107831184 A CN 107831184A CN 201711364437 A CN201711364437 A CN 201711364437A CN 107831184 A CN107831184 A CN 107831184A
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张云平
黄林杰
赖秀梅
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Wuzhou Institutes for Food and Drug Control
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Wuzhou Institutes for Food and Drug Control
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    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N23/00—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00
    • G01N23/22—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by measuring secondary emission from the material
    • G01N23/223—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by measuring secondary emission from the material by irradiating the sample with X-rays or gamma-rays and by measuring X-ray fluorescence

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Abstract

本发明公开了一种X射线荧光分析鉴别真伪朱砂的方法，为朱砂及其含该成份的中成药的鉴别建立了新方法，具有简捷、快速、直观、可靠的特点。属于化学检测领域。该方法采用X射线荧光元素分析仪对样品中的朱砂真伪进行分析鉴别。本发明可用于对紫雪散、保婴散、冰硼散、天王补心丸等中药中的朱砂成分进行分析鉴别。

Description

一种X射线荧光分析鉴别真伪朱砂的方法
技术领域
本发明属于化学检测领域，尤其是一种X射线荧光分析鉴别真伪朱砂的方法。
背景技术
X射线荧光光谱分析方法具分析的元素范围广、干扰少、分析时间短、样品无损等优点，因此元素分析中体现了独特的优势，随着便携式X射线荧光光谱仪市场化，X射线荧光光谱的鉴定技术得到了迅速的发展。
朱砂，又名辰砂，为硫化物类矿物，主含硫化汞(HgS)，采挖后，选取纯净者，用磁铁吸净含铁的杂质，再用水淘去杂石和泥沙。色泽为鲜红或暗红，有光泽，气微、味淡。有清心镇惊，安神作用，有一定的毒性。据笔者调查，市场上的朱砂质量良莠不齐，特别是乡镇的小诊所、小药店，基本都是伪品或劣品。
因此需要一种快速无损的方法来现场检测，从而保障人民群众的用药安全。
发明内容
针对上述不足，本发明旨在提供一种X射线荧光分析鉴别真伪朱砂的方法，为朱砂及其含该成份的中成药的鉴别建立了新方法，具有简捷、快速、直观、可靠的特点。
为了实现上述技术效果，本发明提供的技术方案是这样的：一种X射线荧光分析鉴别真伪朱砂的方法，采用X射线荧光元素分析仪对样品中的朱砂真伪进行分析鉴别。
优选地，所述的X射线荧光元素分析仪为Thermo Scientific Niton XL3t XRFAnalyzer便携式X射线荧光元素分析仪。
优选地，所述的样品为紫雪散、保婴散、冰硼散、天王补心丸中的组合。
优选地，所述的分析鉴别步骤为：取样品粉末置于X射线荧光元素分析仪中，选定铜锌矿模块进行扫描即可。
本发明与传统方法相比，具有以下优点：
本发明利用X射线荧光光谱仪对朱砂进行鉴别分析结果显示，朱砂在La1(9.989)、Lb1(11.823)和Lr1(11.82)处出现了特征性较强的峰，为朱砂的主要有效成分硫化汞的汞元素特征峰，很好地反映出了朱砂的结构特征，含有朱砂的紫雪散、保婴散、冰硼散、天王补心丸均检测到了朱砂的汞元素特征峰，而不含有朱砂的伪品未检测到特征峰。
附图说明
图1为正品朱砂的主要元素特征谱图；
图2为伪品朱砂的主要元素特征谱图；
图3为冰硼散的主要元素特征谱图；
图4为紫雪散的主要元素特征谱图；
图5为保婴散的主要元素特征谱图；
图6为天王救心丸的主要元素特征谱图；
图7为不含朱砂的保婴丹的主要元素特征谱图。
具体实施方式
下面结合具体实施方式，对本发明的权利要求做进一步的详细说明，但不构成对本发明的任何限制，任何在本发明的权利要求保护范围内所做的有限次修改，仍在本发明的权利要求保护范围内。
实施例1
1仪器与样品
Thermo Scientific Niton XL3t XRF Analyzer便携式X射线荧光元素分析仪；朱砂正品，朱砂伪品均为平时日常检验中收集，圴按照《中国药典》2015年版一部朱砂品种项下进行检验确证；紫雪散、保婴散、冰硼散、天王补心丸等样品由市场购买。
2方法与结果
2.1方法
取样品粉末适量，置于样品台中，选用仪器自带的铜锌矿模块进行扫描。
2.2结果
真伪朱砂的XRF法鉴别结果与实验室结果相符，结果见图1-6。
3讨论
比较图谱可以看出伪品朱砂在Hg特征谱La1(9.989)、Lb1(11.823)无相应峰，与正品有显著差异，以此作为鉴别朱砂真伪的依据。有些伪品不但没有汞，甚至含铅量较高，如果患者长期误服伪品朱砂势必对患者身体健康产生危害。
4结论
本文采用X射线荧光光谱法测定样品中汞元素含量并作出元素特征谱对比分析，可快速鉴别朱砂的真伪，与其他鉴别朱砂的方法相比，具有不需要对样品进行预处理、大大节约分析时间、简捷快速、准确客观等优点，克服了其他方法易受主观因素的影响或过于复杂等缺点，可以利用此方法进行现场初筛，提高抽验靶向率，能满足日常监管过程中的快速筛查要求。
以上所述的仅为本发明的较佳实施例，凡在本发明的精神和原则范围内所做的任何修改、等同替换和改进等，均应包含在本发明的保护范围内。

Claims (4)

1.一种X射线荧光分析鉴别真伪朱砂的方法，其特征在于，采用X射线荧光元素分析仪对样品中的朱砂真伪进行分析鉴别。
2.根据权利要求1所述的一种X射线荧光分析鉴别真伪朱砂的方法，其特征在于，所述的X射线荧光元素分析仪为Thermo Scientific Niton XL3t XRF Analyzer便携式X射线荧光元素分析仪。
3.根据权利要求1所述的一种X射线荧光分析鉴别真伪朱砂的方法，其特征在于，所述的样品为紫雪散、保婴散、冰硼散、天王补心丸中的组合。
4.根据权利要求1所述的一种X射线荧光分析鉴别真伪朱砂的方法，其特征在于，所述的分析鉴别步骤为：取样品粉末置于X射线荧光元素分析仪中，选定铜锌矿模块进行扫描即可。
CN201711364437.3A 2017-12-18 2017-12-18 一种x射线荧光分析鉴别真伪朱砂的方法 Pending CN107831184A (zh)

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