CN107823707B - Preparation method of honeycomb-shaped ordered porous graphene coating - Google Patents
Preparation method of honeycomb-shaped ordered porous graphene coating Download PDFInfo
- Publication number
- CN107823707B CN107823707B CN201711039964.7A CN201711039964A CN107823707B CN 107823707 B CN107823707 B CN 107823707B CN 201711039964 A CN201711039964 A CN 201711039964A CN 107823707 B CN107823707 B CN 107823707B
- Authority
- CN
- China
- Prior art keywords
- porous
- water
- honeycomb
- porous graphene
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000000576 coating method Methods 0.000 title claims abstract description 21
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 title claims abstract description 20
- 239000011248 coating agent Substances 0.000 title claims abstract description 20
- 229910021389 graphene Inorganic materials 0.000 title claims abstract description 17
- 238000002360 preparation method Methods 0.000 title claims abstract description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 27
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims abstract description 26
- 239000010936 titanium Substances 0.000 claims abstract description 25
- 238000000034 method Methods 0.000 claims abstract description 15
- 229910052719 titanium Inorganic materials 0.000 claims abstract description 15
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims abstract description 13
- HKUFIYBZNQSHQS-UHFFFAOYSA-N n-octadecyloctadecan-1-amine Chemical compound CCCCCCCCCCCCCCCCCCNCCCCCCCCCCCCCCCCCC HKUFIYBZNQSHQS-UHFFFAOYSA-N 0.000 claims abstract description 9
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 8
- 238000001338 self-assembly Methods 0.000 claims abstract description 8
- 229960005070 ascorbic acid Drugs 0.000 claims abstract description 4
- 235000010323 ascorbic acid Nutrition 0.000 claims abstract description 4
- 239000011668 ascorbic acid Substances 0.000 claims abstract description 4
- 239000003093 cationic surfactant Substances 0.000 claims abstract description 4
- 238000004140 cleaning Methods 0.000 claims abstract description 4
- 230000009881 electrostatic interaction Effects 0.000 claims abstract description 4
- 239000008367 deionised water Substances 0.000 claims description 14
- 229910021641 deionized water Inorganic materials 0.000 claims description 14
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 9
- 101150034825 DODA gene Proteins 0.000 claims description 8
- 235000005583 doda Nutrition 0.000 claims description 8
- 239000007788 liquid Substances 0.000 claims description 7
- 230000008569 process Effects 0.000 claims description 7
- 238000003756 stirring Methods 0.000 claims description 7
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 6
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 6
- 239000005457 ice water Substances 0.000 claims description 6
- 239000010410 layer Substances 0.000 claims description 6
- 238000001035 drying Methods 0.000 claims description 4
- 238000012546 transfer Methods 0.000 claims description 4
- 238000006243 chemical reaction Methods 0.000 claims description 3
- 239000006185 dispersion Substances 0.000 claims description 3
- 229910002804 graphite Inorganic materials 0.000 claims description 3
- 239000010439 graphite Substances 0.000 claims description 3
- 229910052757 nitrogen Inorganic materials 0.000 claims description 3
- 230000003647 oxidation Effects 0.000 claims description 3
- 238000007254 oxidation reaction Methods 0.000 claims description 3
- 239000002356 single layer Substances 0.000 claims description 3
- VWDWKYIASSYTQR-UHFFFAOYSA-N sodium nitrate Inorganic materials [Na+].[O-][N+]([O-])=O VWDWKYIASSYTQR-UHFFFAOYSA-N 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 2
- 239000000463 material Substances 0.000 abstract description 12
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 5
- 210000000963 osteoblast Anatomy 0.000 abstract description 3
- 238000010883 osseointegration Methods 0.000 abstract description 2
- 239000003960 organic solvent Substances 0.000 abstract 3
- 239000000758 substrate Substances 0.000 abstract 2
- NWZSZGALRFJKBT-KNIFDHDWSA-N (2s)-2,6-diaminohexanoic acid;(2s)-2-hydroxybutanedioic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O.NCCCC[C@H](N)C(O)=O NWZSZGALRFJKBT-KNIFDHDWSA-N 0.000 abstract 1
- 239000003638 chemical reducing agent Substances 0.000 abstract 1
- IKDUDTNKRLTJSI-UHFFFAOYSA-N hydrazine monohydrate Substances O.NN IKDUDTNKRLTJSI-UHFFFAOYSA-N 0.000 abstract 1
- 229910001069 Ti alloy Inorganic materials 0.000 description 5
- 239000007943 implant Substances 0.000 description 5
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000010445 mica Substances 0.000 description 2
- 229910052618 mica group Inorganic materials 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- 206010059866 Drug resistance Diseases 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- 206010034133 Pathogen resistance Diseases 0.000 description 1
- 238000001069 Raman spectroscopy Methods 0.000 description 1
- WAIPAZQMEIHHTJ-UHFFFAOYSA-N [Cr].[Co] Chemical class [Cr].[Co] WAIPAZQMEIHHTJ-UHFFFAOYSA-N 0.000 description 1
- 230000002924 anti-infective effect Effects 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000010065 bacterial adhesion Effects 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000003519 biomedical and dental material Substances 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 150000001721 carbon Chemical group 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 239000012295 chemical reaction liquid Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000000703 high-speed centrifugation Methods 0.000 description 1
- 238000009396 hybridization Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000036542 oxidative stress Effects 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
- 238000004528 spin coating Methods 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 210000000689 upper leg Anatomy 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/30—Inorganic materials
- A61L27/306—Other specific inorganic materials not covered by A61L27/303 - A61L27/32
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/04—Metals or alloys
- A61L27/06—Titanium or titanium alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/02—Methods for coating medical devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Transplantation (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention discloses a preparation method of a honeycomb-shaped ordered porous graphene coating. The BreathFigure self-assembly ordered porous structure requires that materials are dissolved in an organic solvent, GO is strong in hydrophilicity but low in dispersibility in the organic solvent, GO can be transferred from a water phase to organic solvent phases such as chloroform and the like by utilizing the electrostatic interaction of a cationic surfactant such as dioctadecyl amine and GO, after the pretreatment such as cleaning of a Ti substrate and the like, a BreathFigure self-assembly method is adopted to prepare a honeycomb-shaped porous GO layer on the Ti substrate. And reducing the porous GO layer by using a reducing agent such as hydrazine hydrate or ascorbic acid to obtain the porous graphene layer. According to the invention, the honeycomb-shaped ordered porous graphene coating is prepared on the surface of the titanium material, and the prepared coating not only can provide antibacterial property, but also can regulate and control the function of osteoblasts and promote the rapid osseointegration of the bone-titanium material.
Description
Technical Field
The invention belongs to the technical field of medicine, and particularly relates to a preparation method of a honeycomb-shaped ordered porous graphene coating.
Background
The biomedical material can diagnose, treat, replace damaged tissues and organs or enhance the functions of the damaged tissues and organs of organisms, belongs to the field of medical instruments, is a cross marginal subject between biology, medicine, materials science and chemistry in research, almost covers the whole field of material science and life science, and has the characteristics of knowledge, technical density and cross of multiple subjects.
The history of biomedical research and development of titanium alloys dates back to the early 40 s of the 20 th century, and the Bothe et al first introduced pure titanium into the biomedical field, and they found that there was no adverse reaction between titanium and rat femur. After 10 years Leventhal further studies confirmed the good biocompatibility of pure titanium. However, since medical stainless steel and cobalt-chromium alloy have become prevalent during world war ii, titanium alloy has been applied and developed slowly in biomedical fields. Since the 60's Branemark used pure titanium for oral implants, pure titanium was widely developed as a surgical implant material, and the alpha titanium alloy Ti3Al2 · 5V was also used clinically as a femoral and tibial replacement material.
The surface of the medical titanium alloy implant material is lack of antibacterial property, so that the infection problem caused by bacterial adhesion is easy to occur. In the aspect of surface anti-infection of titanium alloy implant materials, antibacterial coatings are mostly adopted for modification, but the addition of antibacterial agents such as antibiotics can cause bacterial drug resistance. Graphene is found to have an antibacterial effect through mechanical damage and oxidative stress, etc., which avoids the problem of bacterial resistance. The porous structure has good porosity, can be well adhered to target cells, and has the effect of promoting osteoblast proliferation and differentiation.
At present, no report of preparing a nest-shaped ordered porous graphene coating on the surface of a titanium implant material is found in the prior art.
Disclosure of Invention
In order to overcome the defects in the prior art, the invention provides a preparation method of a honeycomb-shaped ordered porous graphene coating.
The technical scheme is as follows:
a preparation method of a honeycomb-shaped ordered porous graphene coating comprises the following steps:
step 1, GO preparation: 46ml of 98% concentrated H2SO42g of expanded graphite 500nm and 1g of NaNO3Adding the mixture into a 250mL round-bottom flask, and stirring in an ice-water bath; then 6g KMnO were added in six portions over 1 hour4Adding into a round-bottom flask, and then continuing stirring for 2 hours; replacing ice water bath with oil bath, raising the temperature to 35-40 deg.c and maintaining the reaction for 1.5 hr; oxidized at this stageThe process is started slowly, and the viscosity of the system rises continuously; then, 100mL of deionized water is added into the system, the temperature of the system is controlled to be rapidly increased to 98 ℃, and the stirring is continued for 2.5 hours at the temperature; finally, H is slowly dropped into the system2O2Solution until no bubbles are generated;
step 2, ultrasonically cleaning the polished titanium sheet in deionized water, ethanol, acetone and deionized water for 10 minutes respectively, and drying the titanium sheet by nitrogen;
and 3, preparing the Ti surface porous GO coating by adopting a phase transfer combined Breath-Figure self-assembly method.
Further, the specific process of step 3 is: firstly, ultrasonically dispersing GO in deionized water to form stable dispersion liquid, centrifuging at high speed to obtain liquid with an upper layer mainly comprising single-layer GO, adjusting the pH to 9.0 by using 1M NaOH, then adding a chloroform solution containing a DODA cationic surfactant, forming a GO.DODA complex by electrostatic interaction between negative charges on the surface of GO and positive charges carried by DODA, and transferring GO from a water phase to a chloroform phase; dripping a chloroform solution of GO onto the surface of Ti, introducing wet air flow, quickly volatilizing chloroform to cause water vapor to condense on the surface of GO to form a water drop template, self-assembling an ordered porous GO structure, and reserving the porous structure after water drops are evaporated; and reducing the obtained porous GO layer by adopting ascorbic acid to obtain a porous graphene coating.
The invention has the beneficial effects that:
according to the invention, the honeycomb-shaped ordered porous graphene coating is prepared on the surface of the titanium material, and the prepared coating not only can provide antibacterial property, but also can regulate and control the function of osteoblasts and promote the rapid osseointegration of the bone-titanium material.
Drawings
FIG. 1 is a flow chart of graphene oxide reagent addition prepared by the Hummers method;
FIG. 2A flow chart of the preparation of a Ti surface porous GO coating by using a phase transfer combined Breath-Figure self-assembly method.
Detailed Description
The technical solutions of the present invention will be described in further detail with reference to the accompanying drawings and the detailed description.
Preparation and characterization of 1 GO
GO is prepared by adopting an improved Hummers method, a reagent adding flow is shown in figure 1, and the detailed process is as follows:
46ml of 98% concentrated H2SO42g of expanded graphite (500nm) and 1g of NaNO3Added to a 250mL round bottom flask and stirred in an ice water bath. Then 6g KMnO were added in six portions over 1 hour4Added to the round bottom flask and then stirred for an additional 2 hours. The ice-water bath was replaced by an oil bath, the temperature was raised to 35 ℃ to 40 ℃ and the reaction was maintained for 1.5 hours. The oxidation process at this stage begins slowly and the viscosity of the system rises continuously. Then, 100mL of deionized water was added to the system, the temperature of the system was rapidly raised to 98 ℃ with control, and stirring was continued at this temperature for 2.5 hours. Finally, H is slowly dropped into the system2O2Solution until no bubbles are generated.
Washing the prepared GO by adopting a centrifugal method, subpackaging the obtained reaction liquid into different centrifugal tubes, adding a certain amount of deionized water, centrifuging at 6000rpm for 2min, and removing supernatant, wherein the step is repeated for multiple times until the supernatant liquid is in a foggy state. At this point, a pH test is performed and if the pH is between 6 and 7, collection can be performed. For the precipitate, sonication was continued for 30min with an amount of deionized water, followed by centrifugation and collection in the same manner to maximize yield.
After drying the prepared GO, taking a certain amount of powder, and measuring the oxygen content and the oxidation degree of the powder by using an element analyzer; ultrasonically dispersing GO in water, spin-coating to a mica sheet, and observing the size and the thickness of the mica sheet by adopting AFM; SP of carbon atom in GO2Hybrid and SP3Hybridization was characterized by Raman spectroscopy.
Self-assembly of 2 Ti surface ordered porous graphene coating
And ultrasonically cleaning the polished titanium sheet in deionized water, ethanol, acetone and deionized water for 10 minutes respectively, and drying by nitrogen.
The Ti surface porous GO coating is prepared by adopting a phase transfer combined Breath-Figure self-assembly method, the process is shown in Figure 2, GO is ultrasonically dispersed in deionized water to form stable dispersion liquid, liquid with an upper layer mainly being monolayer GO is obtained through high-speed centrifugation, the pH value is adjusted to 9.0 by 1M NaOH, then chloroform solution containing DODA cationic surfactant is added, a GO.DODA complex is formed by the electrostatic interaction between negative charges on the surface of GO and positive charges carried by DODA, and GO can be transferred from a water phase to a chloroform phase. Drip the chloroform solution of GO to the Ti surface, let in moist air current simultaneously, chloroform volatilizees rapidly, leads to vapor to condense on the GO surface, forms the water droplet template, and the orderly porous GO structure of self-assembly waits the water droplet evaporation back, and porous structure remains. And reducing the obtained porous GO layer by adopting ascorbic acid to obtain a porous graphene coating.
The above description is only a preferred embodiment of the present invention, and the scope of the present invention is not limited thereto, and any simple modifications or equivalent substitutions of the technical solutions that can be obviously obtained by those skilled in the art within the technical scope of the present invention are within the scope of the present invention.
Claims (1)
1. A preparation method of a honeycomb-shaped ordered porous graphene coating is characterized by comprising the following steps:
step 1, GO preparation: 46mL of 98% concentrated H2SO42g of expanded graphite 500nm and 1g of NaNO3Adding the mixture into a 250mL round-bottom flask, and stirring in an ice-water bath; then 6g KMnO were added in six portions over 1 hour4Adding into a round-bottom flask, and then continuing stirring for 2 hours; replacing ice water bath with oil bath, raising the temperature to 35-40 deg.c and maintaining the reaction for 1.5 hr; the oxidation process at this stage starts slowly, and the viscosity of the system rises continuously; then, 100mL of deionized water is added into the system, the temperature of the system is controlled to be rapidly increased to 98 ℃, and the stirring is continued for 2.5 hours at the temperature; finally, H is slowly dropped into the system2O2Solution until no bubbles are generated;
step 2, ultrasonically cleaning the polished titanium sheet in deionized water, ethanol, acetone and deionized water for 10 minutes respectively, and drying the titanium sheet by nitrogen;
step 3, preparing the Ti surface porous GO coating by adopting a phase transfer combined Breath-Figure self-assembly method, wherein the specific process is as follows: firstly, ultrasonically dispersing GO in deionized water to form stable dispersion liquid, centrifuging at high speed to obtain liquid with an upper layer mainly comprising single-layer GO, adjusting the pH value to 9.0 by using 1M NaOH, then adding a chloroform solution containing a DODA cationic surfactant, forming a GO-DODA complex by electrostatic interaction between negative charges on the surface of GO and positive charges on the surface of DODA, and transferring the GO from a water phase to a chloroform phase; dripping a chloroform solution of GO onto the surface of Ti, introducing wet air flow, quickly volatilizing chloroform to cause water vapor to condense on the surface of GO to form a water drop template, self-assembling an ordered porous GO structure, and reserving the porous structure after water drops are evaporated; and reducing the obtained porous GO layer by adopting ascorbic acid to obtain a porous graphene coating.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711039964.7A CN107823707B (en) | 2017-10-25 | 2017-10-25 | Preparation method of honeycomb-shaped ordered porous graphene coating |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711039964.7A CN107823707B (en) | 2017-10-25 | 2017-10-25 | Preparation method of honeycomb-shaped ordered porous graphene coating |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107823707A CN107823707A (en) | 2018-03-23 |
| CN107823707B true CN107823707B (en) | 2021-06-25 |
Family
ID=61651128
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711039964.7A Expired - Fee Related CN107823707B (en) | 2017-10-25 | 2017-10-25 | Preparation method of honeycomb-shaped ordered porous graphene coating |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107823707B (en) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104119529B (en) * | 2014-08-02 | 2016-04-06 | 桂林理工大学 | The preparation method of the polyaniline/graphene composite material of nano tubular structure |
| US10053791B2 (en) * | 2015-09-25 | 2018-08-21 | Jackson State University | Method for obtaining a composite coating on titanium implants for tissue engineering |
| CN105482139A (en) * | 2016-01-18 | 2016-04-13 | 浙江工业大学 | Preparation method of porous polystyrene thin-film material with uniform pore diameters |
| CN106245091B (en) * | 2016-07-26 | 2019-11-08 | 兰溪绿丞科技服务有限公司 | Composite titania material and its preparation method and application |
-
2017
- 2017-10-25 CN CN201711039964.7A patent/CN107823707B/en not_active Expired - Fee Related
Non-Patent Citations (2)
| Title |
|---|
| Assembly of graphene nanocomposites into honeycomb-structured macroporous films with enhanced hydrophobicity;Hongmin Ma等;《New Journal of Chemistry》;20121219;第37卷(第5期);第2.3-2.4节 * |
| 基于聚乳酸和氧化石墨烯的功能化改性及生物医学应用研究;赵长虹;《中国博士学位论文全文数据库医药卫生科技辑》;20170215(第2期);第2.1、2.2.4、3.2.2、5.2.2、5.2.4小节 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN107823707A (en) | 2018-03-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Tiwari et al. | Accelerated bone regeneration by two-photon photoactivated carbon nitride nanosheets | |
| Pei et al. | Single-walled carbon nanotubes/hydroxyapatite coatings on titanium obtained by electrochemical deposition | |
| WO2021008092A1 (en) | Method for preparing near-infrared responsive functional coating on surface of cylindrical titanium nail and application | |
| Mazare et al. | Changing bioperformance of TiO2 amorphous nanotubes as an effect of inducing crystallinity | |
| Huo et al. | Fabrication, modification, and biomedical applications of anodized TiO 2 nanotube arrays | |
| Ahmed et al. | A study of calcium carbonate/multiwalled-carbon nanotubes/chitosan composite coatings on Ti–6Al–4V alloy for orthopedic implants | |
| RU2630055C2 (en) | Biocompatible component | |
| Peng et al. | Thin calcium phosphate coatings on titanium by electrochemical deposition in modified simulated body fluid | |
| Shivaram et al. | Mechanical degradation of TiO2 nanotubes with and without nanoparticulate silver coating | |
| JP2010536534A (en) | Method for generating nanostructures on the surface of a medical implant | |
| CN102560598B (en) | Method for preparing medical titanium material with high anti-cancer and antibacterial properties | |
| ITMI20110312A1 (en) | DENTAL PLANT WITH NANOSTRUCTURED SURFACE AND PROCEDURE FOR ITS ACHIEVEMENT | |
| CN102525827A (en) | Method for preparing medical titanium material with long-acting antibacterial property and good biocompatibility | |
| Raj et al. | Fabrication of biopolymers reinforced TNT/HA coatings on Ti: Evaluation of its Corrosion resistance and Biocompatibility | |
| Wu et al. | Nano-hydroxyapatite coated TiO2 nanotubes on Ti-19Zr-10Nb-1Fe alloy promotes osteogenesis in vitro | |
| Liu et al. | Tea polyphenol-reduced graphene oxide deposition on titanium surface enhances osteoblast bioactivity | |
| CN103520776B (en) | Medical titanium substrate material and manufacturing method thereof | |
| CN107761148A (en) | A kind of method that fibroin albumen hydroxyapatite coating layer is prepared in metal surface | |
| CN107823707B (en) | Preparation method of honeycomb-shaped ordered porous graphene coating | |
| Bai et al. | Fabrication and characterization of gold nanoparticle-loaded TiO 2 nanotube arrays for medical implants | |
| Takada et al. | Carbon nanohorn coating by electrodeposition accelerate bone formation on titanium implant | |
| Meyerink et al. | Transparent titanium dioxide nanotubes: processing, characterization, and application in establishing cellular response mechanisms | |
| WO2021007922A1 (en) | Graphene cochlear implant electrode and manufacturing method therefor | |
| CN106086842A (en) | A kind of metal surface high biological compatibility coating and preparation method | |
| Puah et al. | Spin-coated graphene oxide as a biomaterial for Wharton’s Jelly derived mesenchymal stem cell growth: A preliminary study |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20210625 |