CN107823255A - One kind quail of laying eggs increases egg oral liquid and preparation method thereof with liver protection - Google Patents
One kind quail of laying eggs increases egg oral liquid and preparation method thereof with liver protection Download PDFInfo
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- CN107823255A CN107823255A CN201711268328.1A CN201711268328A CN107823255A CN 107823255 A CN107823255 A CN 107823255A CN 201711268328 A CN201711268328 A CN 201711268328A CN 107823255 A CN107823255 A CN 107823255A
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- 208000032839 leukemia Diseases 0.000 description 1
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- 230000002503 metabolic effect Effects 0.000 description 1
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- -1 phytosterol Substances 0.000 description 1
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- 229940007046 shigella dysenteriae Drugs 0.000 description 1
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- 239000011734 sodium Substances 0.000 description 1
- IZPNTDOWOBGHEG-UHFFFAOYSA-M sodium benzene formate Chemical compound [Na+].[O-]C=O.C1=CC=CC=C1 IZPNTDOWOBGHEG-UHFFFAOYSA-M 0.000 description 1
- UVVPZMPJAYXZDN-UHFFFAOYSA-M sodium;benzoic acid;benzoate Chemical compound [Na+].OC(=O)C1=CC=CC=C1.[O-]C(=O)C1=CC=CC=C1 UVVPZMPJAYXZDN-UHFFFAOYSA-M 0.000 description 1
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
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- A61K36/36—Caryophyllaceae (Pink family), e.g. babysbreath or soapwort
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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Abstract
The invention discloses one kind quail of laying eggs to increase egg oral liquid and preparation method thereof with liver protection, and the quail of laying eggs increases egg oral liquid its main component with liver protection and is made up of according to mass parts following components：8 parts of oriental wormwood 4 part, 8 parts of radix pseudostellariae 4 part, 6 parts of barrenwort 2 part, 2 parts 6 parts of mountain scissors grass, 6 parts of rainbow conk 2 part, 4 parts of geranium wilfordii 1 part.The present invention lay eggs quail with liver protection increase egg oral liquid quail laying rate and average daily egg size are significantly improved to quail, so as to improve the economic benefit of laying eggs of quail.Different degrees of improvement is laid eggs quality.And also indicate that quail liver protection of laying eggs increases egg oral liquid and can mitigate the fatty liver denaturation of quail, certain protective effect is played to liver.
Description
Technical field
The invention belongs to quail cultural technique field, specifically, it is related to one kind quail of laying eggs and increases egg oral liquid with liver protection
And preparation method thereof.
Background technology
China is a livestock breed aquatics big country, and chicken, duck, goose and quail breeding stock are huge, bigger to eggs demand.If
It can in this regard have breakthrough, then push whole poultry farming to, also have the people to be good for the increased quality of the aquaculture in China
Very big effect can be played in terms of health.
Quail egg has invigorating qi and benefiting blood, physical and mental health, prevention rich in various nutrients such as amino acid, lecithin, cephalins
The function such as cell degradation and senility of humanbody, it is preferable nourishing food.Cultivation quail is one, and investment is small, the output value is high, fund is all
Turn the fast, aquaculture of high financial profit, there is vast potential for future development.Many factors influence whether quail in breeding process
Egg laying performance, therefore improve egg laying performance particularly important influence in quail cultivates of quail.But quail with the increase of age,
Fatty liver conditions increase therewith, and egg production declines, and causes profit to reduce.
Liver is an important metabolic organ in animal body, closely related with body digestion, removing toxic substances, immune etc..
Liver function can cause various diseases extremely.Wherein esters metabolic disorder can cause liver cell fat accumulation excessive, produce fat
Fat liver, influence the eubolism function of body.Liver diseases can have a strong impact on poultry egg laying performance.
At present, the traditional Chinese medicine oral liquid that can be also directed to prevention and treatment Fatty Liver In Quails without pertinent literature report occurs, pin
The traditional Chinese medicine oral liquid that demand research and development to market can prevent and treat Fatty Liver In Quails is significant.
The content of the invention
In view of this, the present invention for it is above-mentioned the problem of, there is provided one kind lay eggs quail with liver protection increase egg oral liquid and its
Preparation method.
In order to solve the above-mentioned technical problem, the invention discloses one kind lay eggs quail with liver protection increase egg oral liquid, mainly press
It is made up of according to mass parts following components：4 parts -8 parts of oriental wormwood, 4 parts -8 parts of radix pseudostellariae, 2 parts -6 parts of barrenwort, 2 part -6 of mountain scissors grass
Part, 2 parts -6 parts of rainbow conk, 1 part -4 parts of geranium wilfordii.
Increase the preparation method of egg oral liquid with liver protection the invention also discloses a kind of quail of laying eggs, comprise the following steps：
Step 1, weigh：Following components is weighed according to mass parts：4 parts -8 parts of oriental wormwood, 4 parts -8 parts of radix pseudostellariae, barrenwort 2
- 6 parts of part, 2 parts -6 parts of mountain scissors grass, 2 parts -6 parts of rainbow conk, 1 part -4 parts of geranium wilfordii；
Step 2, by load weighted each component distilled water immersion, carry out decoction processing；Decoction is treated after the completion of decocting every time
Cooling, is filtered with funnel, and the filtrate collected twice carries out centrifugal treating, discards bottom residues, collects supernatant liquor；
Step 3, supernatant liquor is carried out to concentration, adding ethanol thereto after solution to be concentrated cooling carries out alcohol precipitation, side
The stirring of ethanol side is added, is subsequently placed in 3 DEG C of refrigerators and stands one day, takes out and stands liquid, carries out filtration treatment, is reclaimed in filtrate
Ethanol；
Step 4, the decoction after recovery ethanol is taken out, add distilled water and sodium benzoate and benzoic acid thereto, prepare
Obtain decoction；Liquid PH value is adjusted with NaOH, made decoction is dispensed, sterilizes, quail of laying eggs is prepared and is increased with liver protection
Egg oral liquid.
Further, the soak time in the step 2 is 15-45min, and the solid-liquid ratio of decoction is 1:12-1:20, altogether
Decoct 2 times, decoct 1-2h every time.
Further, the centrifugation time in the step 2 is 8-12min, and centrifugal rotational speed is 2000 revs/min.
Further, the volumetric concentration of the ethanol in the step 3 is 50%-80%.
Further, the liquor strength after the concentration in the step 3 is 1.02-1.05g/mL.
Further, the ratio between each component quality total amount is 1 in the medicine liquid volume total amount in the step 4 and step 1:1, benzene
Sodium formate is equal with benzoic acid addition, and the mass ratio of sodium benzoate and each component quality total amount in step 1 is 1:280.
Further, the mass concentration of the NaOH in the step 4 is 0.2%, and liquid PH value is 5~7.
Compared with prior art, the present invention can be obtained including following technique effect：
The present invention lay eggs quail with liver protection increase egg oral liquid quail laying rate and average daily egg size are significantly improved to quail of laying eggs,
So as to improve the economic benefit of laying eggs of quail.Different degrees of improvement is laid eggs quality.And also indicate that quail of laying eggs is increased with liver protection
Egg oral liquid can mitigate the fatty liver denaturation of quail, and certain protective effect is played to liver.
Certainly, any product for implementing the present invention it is not absolutely required to reach all the above technique effect simultaneously.
Brief description of the drawings
Accompanying drawing described herein is used for providing a further understanding of the present invention, forms the part of the present invention, this hair
Bright schematic description and description is used to explain the present invention, does not form inappropriate limitation of the present invention.In the accompanying drawings：
Fig. 1 is oriental wormwood Qualitive test figure of the present invention；Wherein, 1 negative control is represented, 2-4 represents test sample, and 5 represent control
Group；
Fig. 2 is radix pseudostellariae Qualitive test figure of the present invention；Wherein, 1 negative control is represented, 2-4 represents control medicinal material, 3-6 generations
Table test sample；
Fig. 3 is barrenwort Qualitive test figure of the present invention；Wherein, 1-3 represents test sample, and 4 represent negative control, 5 representatives pair
According to product；
Fig. 4 is oral liquid high-efficient liquid phase chromatogram of the present invention；
Fig. 5 is escoparone high-efficient liquid phase chromatogram of the present invention；
Fig. 6 is each group quail liver morphology (hematoxylin eosin staining, X400) of the present invention, wherein, a represents blank group, b
Liver protection group is represented, c represents female group of benefit.
Embodiment
Describe embodiments of the present invention in detail below in conjunction with embodiment, thereby to the present invention how application technology hand
Section can fully understand and implement according to this to solve technical problem and reach the implementation process of technical effect.
The present invention provide one kind lay eggs quail with liver protection increase egg oral liquid, its main component is according to mass parts by following components
Form：4 parts -8 parts of oriental wormwood, 4 parts -8 parts of radix pseudostellariae, 2 parts -6 parts of barrenwort, 2 parts -6 parts of mountain scissors grass, 2 parts -6 parts of rainbow conk, old stork
1 part -4 parts of grass.
Wherein, traditional Chinese medicinal components oriental wormwood mainly can clearing heat and promoting diuresis；Removing jaundice.Cure mainly：Jaundice, difficult urination, wet sore itch, infection
Property the pharmaceutical research such as icteric hepatitis have cholagogic, liver function protecting is antipyretic, anti-inflammatory, reducing blood lipid, the effect such as coronary dilatation, at present the traditional Chinese medical science
The achievement worked it out with western medicine joint research oriental wormwood composition.Oriental wormwood has significant hepatoprotective effect, to Combined hepatitis A and B vaccine, jaundice
Type hepatitis, there is the effect of notable.There is cholagogic, promote choleresis, increase the effect of cholic acid and bilirubin discharge in bile, can increase
Add heart coronary artery CBF, improve microcirculation, and have hypotensive, reducing blood lipid, anticoagulation, diuresis is antipyretic to relieving asthma, drive away roundworm and
Suppress the effect of a variety of pathogenic dermatophytes and bacterium.
Its property of radix pseudostellariae is sweet, mild-natured, slight bitter；Enter spleen and lung two to pass through, replenish qi to invigorate the spleen, be promoting production of body fluid and nourishing the lung, for treating
The illnesss such as insufficiency of the spleen body is tired, poor appetite, eak after being ill, deficiency of both vital energy and Yin, spontaneous perspiration dry, dryness of the lung dry cough.Clinically it can be used alone
Or be used cooperatively with other Chinese medicines, or for prescribed preparation.Clinic shows in recent years, and radix pseudostellariae is in treatment hepatitis, diabetes, hat
Obtained in terms of the difficult and complicated illness such as worry, angina pectoris, secondary aplastic anemia, leukopenia, hyperthyroidism, scrofula
New progress.
Barrenwort acrid-sweet flavor is warm-natured, walks liver kidney two warp.For mend the gate of vitality, strengthening the essence gas, strengthening the bones and muscles, tonifying kidney and strengthening yang key medicine, face
Bed be usually used in treating impotence in male do not lift, the disease such as involuntary emission premature ejaculation, urinary incontinence and female sterility.Modern study shows, excessive sheep
The leaves of pulse plants is containing compositions such as icariine, volatile oil, ceryl alcohol, phytosterol, tannin, vitamin Es.The excited sexual performance of energy, has rush to animal
Enter gonopoiesis effect.(causing peripheral vasodilation), hypoglycemic, diuresis, kobadrin and vitamin E sample is also depressured to make
With.Pharmacological experiment study shows that barrenwort can increase cardiovascular and cerebrovascular CBF, promotes hematopoiesis function, immunologic function and Bone m etabolism,
With anti-aging, antitumor and other effects.
Mountain scissors grass has the effect of heat-clearing, removing toxic substances.Modern pharmacological research confirms to have preferable spasmolysis, calmness, anti-inflammatory, disappeared
The pharmacological actions such as swollen, antipyretic and promotion adrenal cortex function.Rainbow conk nature and flavor：It is sweet；It is light；It is slightly cold.Channel tropism：Liver；Spleen；Lung channel function
Cure mainly：Invigorating spleen to remove dampness；It is relieving cough and asthma；It is clearing heat and detoxicating；It is antitumor.Main CAH；Hepatic sclerosis；Chronic bronchitis；
Infantile spasm bronchitis；Abscess of throat；Kinds of tumors；Rheumatoid arthritis；Leukaemia.
Geranium wilfordii bitter, micro-pungent, it is mild-natured.Return liver, large intestine channel.Geranium wilfordii has a broad antifungal spectrum, its flavonoids have to a variety of bacillus
Inhibitory action, aureomycin, tetracycline are less than to the bacteriostasis of shigella dysenteriae F1 strains, higher than berberine, Herba Andrographitis, with chloramphenicol
And streptomysin is close；Its herb decoction also have to staphylococcus aureus, beta streptococcus, streptococcus pneumonia, micrococcus catarrhalis compared with
Obvious inhibitory action.This product herb decoction to the 68-1 strains of Asia influenza A virus capital section and parainfluenza virus drum celestial platform strain and
Herpes simplex virus has obvious inhibitory action.Geranium wilfordii water extract can make rabbit blood solidification enhancing；Alcohol precipitation decoction has
Notable antitussive effect；The energy anti-lipid peroxidation such as tannin and its catabolite corilagin, there is anti-oxidant, liver protection to make
With；Pelargonium has antiinflammatory action.All formulas are matched have heat-clearing toxic removing, promoting blood circulation it is logical become silted up, nourish liver and spleen and strengthening tendons kidney tonifying,
QI invigorating supports the effect of smart.
This oral liquid is made up of oriental wormwood, radix pseudostellariae, barrenwort, mountain scissors grass, rainbow conk, geranium wilfordii.We dispel with heat-clearing
The effect of smart, is supported in poison, the logical silt of promoting blood circulation, nourishing liver and strengthening tendons kidney tonifying, QI invigorating.Cumarin is the main component contained in oriental wormwood,
The synthesis of clotting factor in liver can be suppressed, there is obvious hepatoprotective effect.
The present invention also provides the preparation method that a kind of quail of laying eggs increases egg oral liquid with liver protection, comprises the following steps：
Step 1, weigh：Following components is weighed according to mass parts：4 parts -8 parts of oriental wormwood, 4 parts -8 parts of radix pseudostellariae, barrenwort 2
- 6 parts of part, 2 parts -6 parts of mountain scissors grass, 2 parts -6 parts of rainbow conk, 1 part -4 parts of geranium wilfordii；
Step 2, by load weighted each component distilled water, it is 1 to soak after 15-45min according to solid-liquid ratio:12-1:20 enter
Row decoction is handled, and is decocted 2 times altogether, is decocted 1-2h every time；Treat that decoction cools down after the completion of decocting every time, filtered with funnel, collected
Filtrate twice, centrifuge 8-12min is placed in, 2000 revs/min of centrifugal rotational speed, discards bottom residues, it is clear to collect upper strata
Liquid.
Step 3, supernatant liquor is subjected to concentration, decoction is concentrated into the range of 1.02-1.05g/mL；Solution to be concentrated
The ethanol for adding 50%-80% after cooling thereto carries out alcohol precipitation, stirs, is subsequently placed at quiet in 3 DEG C of refrigerators when adding ethanol
Put one day, take out and stand liquid, carry out filtration treatment, reclaim the ethanol in filtrate.
Step 4, the decoction after recovery ethanol is taken out, add appropriate distilled water and sodium benzoate benzoic acid, medicine thereto
It is 1 that liquid, which accumulates the ratio between each component quality total amount in total amount and step 1,:1, sodium benzoate is equal with benzoic acid addition, benzoic acid
Sodium and the mass ratio of each component quality total amount in step 1 are 1:280, with 0.2%NaOH adjust pH value make liquid PH value 5~7 it
Between, made decoction is dispensed, sterilized, quail of laying eggs is prepared and increases egg oral liquid with liver protection.
Embodiment 1
Weigh following components：It is oriental wormwood 600g, radix pseudostellariae 600g, barrenwort 400g, mountain scissors grass 400g, rainbow conk 400g, old
Stork grass 200g；Above-mentioned prescription is taken in large beaker, adds a certain amount of distilled water, it is 1 to soak after 0.5h according to solid-liquid ratio:18 are carried out
Decoction is handled, and is decocted 2 times altogether, is decocted 1.5h every time.Treat that decoction cools down after the completion of decocting every time, filtered with funnel, collect two
Secondary filtrate, centrifuge 10min is placed in, 2000 revs/min of centrifugal rotational speed, discards bottom residues, collects supernatant liquor.Enter
Row concentration, makes decoction be concentrated into 1.04g/mL.Certain density ethanol is added thereto after solution to be concentrated cooling to enter
Row alcohol precipitation, stirred when adding 60% ethanol, be subsequently placed in 3 DEG C of refrigerators and stand one day.Take out and stand liquid, carry out at filtering
Reason, reclaim the ethanol in filtrate.The decoction after recovery ethanol is taken out, adds the benzoic acid of appropriate distilled water and 10g thereto
The benzoic acid of sodium and 10g, makes decoction reach 2800mL.PH value is adjusted to make liquid PH value between 6 with 0.2%NaOH.Finally by institute
The 2800ml of system decoction is dispensed, sterilizing, you can quail of laying eggs is prepared and increases egg oral liquid with liver protection.
Embodiment 2
Following components is weighed according to mass parts：Oriental wormwood 400g, radix pseudostellariae 800g, barrenwort 200g, mountain scissors grass 600g, cloud
Sesame 200g, geranium wilfordii 400g；By load weighted each component distilled water, it is 1 to soak after 15min according to solid-liquid ratio:20 are decocted
Processing is boiled, decocts 2 times altogether, decocts 1h every time；Treat that decoction cools down after the completion of decocting every time, filtered, collected twice with funnel
Filtrate, centrifuge 12min is placed in, 2000 revs/min of centrifugal rotational speed, discards bottom residues, collects supernatant liquor.By upper strata
Clear liquid carries out concentration, decoction is concentrated into 1.02g/mL；80% ethanol progress is added after solution to be concentrated cooling thereto
Alcohol precipitation, stirred when adding ethanol, be subsequently placed in 3 DEG C of refrigerators and stand one day, taken out and stand liquid, carry out filtration treatment, recovery
Ethanol in filtrate.The decoction after recovery ethanol is taken out, adds appropriate distilled water and sodium benzoate and benzoic acid, medicine thereto
It is 1 that liquid, which accumulates the ratio between each component quality total amount in total amount and Chinese herbal medicine,:1, sodium benzoate is equal with benzoic acid addition, benzoic acid
Sodium and the mass ratio of Chinese herbal medicine each component quality total amount are 1:280, decoction is reached 2800mL.PH value is adjusted to make with 0.2%NaOH
Liquid PH value is finally dispensed made 2800ml decoction between 5, sterilizing, quail liver protection of laying eggs is prepared
Increase egg oral liquid.
Embodiment 3
Following components is weighed according to mass parts：Oriental wormwood 800g, radix pseudostellariae 400g, barrenwort 600g, mountain scissors grass 200g, cloud
Sesame 600g, geranium wilfordii 100g；By load weighted each component distilled water, it is 1 to soak after 45min according to solid-liquid ratio:12 are decocted
Processing is boiled, decocts 2 times altogether, decocts 2h every time；Treat that decoction cools down after the completion of decocting every time, filtered, collected twice with funnel
Filtrate, centrifuge 8min is placed in, 2000 revs/min of centrifugal rotational speed, discards bottom residues, collects supernatant liquor.By upper strata
Clear liquid carries out concentration, decoction is concentrated into the range of 1.05g/mL；50% second is added after solution to be concentrated cooling thereto
Alcohol carries out alcohol precipitation, is stirred when adding ethanol, is subsequently placed in 3 DEG C of refrigerators and stands one day, takes out and stands liquid, carries out at filtering
Reason, reclaim the ethanol in filtrate.The decoction after recovery ethanol is taken out, adds appropriate distilled water and sodium benzoate and benzene thereto
The ratio between each component quality total amount is 1 in formic acid, medicine liquid volume total amount and Chinese herbal medicine:1, sodium benzoate and benzoic acid addition phase
Mass ratio Deng, sodium benzoate and Chinese herbal medicine each component quality total amount is 1:280, decoction is reached 2800mL.Use 0.2%NaOH
Adjust pH value liquid PH value is finally dispensed made 2800ml decoction 7, sterilize, quail use of laying eggs is prepared
Liver protection increases egg oral liquid.
The oral liquid quality standard of embodiment 4
First, the Qualitive test of oriental wormwood
10mL oral liquids are measured in beaker, 15mL ethyl acetate is added and carries out shaking extraction.After 15min, extraction is taken out
Liquid, then by same procedure extraction once.Extract solution twice is collected, is rotated, until extract solution is evaporated.2mL is added thereto
Methanol, as need testing solution.Take the oral liquid without oriental wormwood prepared according to same process.Operated according to the method described above.
The methanol solution of gained is as negative control solution.1g oriental wormwood control medicinal materials are taken, 20mL methanol is added, is placed in Ultrasound Instrument and handles
0.5h.Extract solution is filtered, is evaporated.2mL methanol is added thereto, as control medicinal material solution.With traditional Chinese medicines in version in 2015
Allusion quotation TLC methods are standard.Above-mentioned three kinds of solution 5 to 10 μ L are drawn with capillary, are put on silica gel g thin-layer plate.Treat that origin decoction is done
After dry, it is put into exhibition layer cylinder and deploys.Solvent is butyl acetate:Formic acid:Water (7：3：3).After a period of time, lamellae is taken out.
After its drying, it is placed under 365nm ultraviolet lamps and observes.As a result Fig. 1 is seen.Test sample is with control medicinal material in lamellae upper end spot
It is corresponding.Negative control difference is obvious.
2nd, the Qualitive test of radix pseudostellariae
10mL oral liquids are measured in beaker, the water saturated n-butanols of 20mL is added and carries out shaking extraction.After 15min, take
Go out extract solution, then by same procedure extraction once.Extract solution twice is collected, is rotated, until extract solution is evaporated.Add 2mL
Methanol, as need testing solution.Take the oral liquid without radix pseudostellariae prepared according to same process.Grasped according to the method described above
Make.The methanol solution of gained is as negative control solution.1g radix pseudostellariae control medicinal materials are taken, are moistened with little water.Then add
10mL n-butanols, are placed in Ultrasound Instrument and handle 0.5h.Extract solution is filtered, is evaporated.2mL methanol is added, as control medicinal material
Solution.Using version Chinese Pharmacopoeia TLC methods in 2015 as standard.Above-mentioned three kinds of solution 5 to 10 μ L are drawn with capillary, are put in silica G
On lamellae.After the drying of origin decoction, it is put into exhibition layer cylinder and deploys.Solvent is n-butanol:Glacial acetic acid:Water (7：1.5：1).
After a period of time, lamellae is taken out.After its drying, using 10% ethanol solution of sulfuric acid as developer.Add in 105 DEG C of baking ovens
Heat, until showing obvious spot.As a result Fig. 2 is seen.The spot in the middle part of lamellae is corresponding with control medicinal material for test sample.It is negative
Contrast difference is obvious.
3rd, the Qualitive test of barrenwort
10mL oral liquids are measured in beaker, add 20mL methanol.10min is centrifuged after mixing, takes out supernatant liquor.To it
Rotated, until being evaporated.2mL methanol is added, as need testing solution.Take the mouth without barrenwort prepared according to same process
Take liquid.Operated according to the method described above.The methanol solution of gained is as negative control solution.Icariin reference substance 1mg is taken,
Add methanol 2ml dissolvings.As reference substance solution.Using version Chinese Pharmacopoeia TLC methods in 2015 as standard.Drawn with capillary above-mentioned
Three kinds of μ L of solution 5 to 10, put on silica gel g thin-layer plate.After the drying of origin decoction, it is put into exhibition layer cylinder and deploys.Solvent is
Ethyl acetate:Butanone:Formic acid:Water (10：2：1：2).After a period of time, lamellae is taken out, carries out drying processing.Then by thin layer
Plate is placed under 365nm ultraviolet lamps and observed, and as a result sees Fig. 3.Test sample is corresponding in lamellae upper end spot with reference substance.It is negative
Contrast difference is obvious.
4th, high performance liquid chromatography surveys tonka-bean cellulose content
Chromatographic condition：Chromatographic column is Agilent Microsorb 100-5SB-C18 posts, and specification is 250mm × 4.6mm, 5
μm；Mobile phase is acetonitrile:Water (34：66)；Detection wavelength is 340nm；Flow velocity is 1mL/min；Column temperature is 25 DEG C；
The preparation of reference substance solution：Precision weighs escoparone 6.8mg, adds methanol constant volume to 100mL, it is molten to carry out ultrasound
Solve 0.5h.Reference substance solution, concentration 0.068mg/mL. is made
The preparation of need testing solution：Precision measures oral liquid 1mL, adds methanol constant volume to 100mL, carries out ultrasonic dissolution
0.5h.Use filtering with microporous membrane.Need testing solution is made.
System suitability test：The accurate μ L of sample introduction 10 reference substance solution and need testing solution.Carried out according to experimental condition
Detection.Collection of illustrative plates shows that escoparone is good in 8.4min or so appearances, peak shape.Test sample also has absworption peak in 8.4min or so,
Time is consistent with escoparone.Remaining each component has good separation relation in oral liquid.Oral liquid chromatographic peak profile figure is shown in Fig. 4,
Escoparone chromatographic peak profile figure is shown in Fig. 5.
Linear relationship is investigated：The accurate μ L's of sample introduction 1,5,10,15,20 of difference shines product solution.According to chromatographic condition, peak is determined
Area.Using peak area as ordinate Y, reference substance sample size is abscissa X (6.8-136 μ g), draws standard curve.The standard of obtaining is bent
Line equation is Y=6 × 106X+18263, r=1.
Precision test：The accurate μ L reference substance solutions of sample introduction 10.Continuously repeat sample introduction 6 times.Examined according to chromatographic condition
Survey.Each peak area is recorded, as a result RSD is 0.59%.
Stability test：Oral liquid is taken, need testing solution is configured according to test sample preparation method.After preparation 0,4,
8th, the μ L of sample introduction 10 during 24h.Record each peak area.As a result its RSD is 0.63%.
Replica test：Take with a oral liquid, 6 parts of need testing solutions are made by experimental condition.Every part of test sample sample introduction
10 μ L, record peak area.As a result RSD is 1.83%.
Average recovery is tested：Take totally 6 parts of oral liquid, every part of each 1mL.Escoparone 0.345,0.351 is separately added into,
0.432,0.445,0.518,0.528mg.According to test sample preparation method, sample-adding recovery test liquid is made.Content is determined, is calculated
The rate of recovery.Calculate average recovery rate is 98.13%, RSD 1.19%.Average recovery the results are shown in Table 8.
The average recovery result of table 8
Oral liquid determines：Take three portions of oral liquids that need testing solution is made, every part of μ L of sample introduction 10, determine every part of peak area, meter
Calculate tonka-bean cellulose content.As a result three parts of oral liquid tonka-bean cellulose contents are respectively 0.428mg/mL, 0.436mg/mL, 0.445mg/mL.
The oral liquid of the present invention of embodiment 5 is to the influence to quail egg laying performance
First, experimental method
1st, packet and administering mode：The age in days of quail 300,100~130g of body weight, female, 600 (nine liters of Sichuan food public affairs
Department), 3 groups are randomly divided into, is 4 cages per component.Per 50, cage：Blank group, beneficial female group, liver protection group.Experimental group is fed and uses oral liquid, is pressed
4ml/kg/ cages/day.It is mixed into feed administration；Blank group gives the physiological saline with dosage to be mixed into forage feed；Beneficial female group 4ml/kg/
Cage/day.Feed 30 days.Daily 16：00-17：00 collects all quail eggs.
2nd, the measure of egg laying performance：Egg production is calculated, claims total egg size.Using electronic balance weighing, 0.01g is accurate to.
Calculate laying rate, it is average lay eggs day, average egg weight, lopsided egg ratio (daily/weekly), and daily record data.Observe quail
Figure, feather, and quail egg profile color, if having blood, meat spot egg, statistics blood, the egg number of meat spot.
3rd, liver section is made
After egg laying performance off-test, every group takes experiment quail 10, is butchered, takes liver, liver is made and cut
Piece, observation liver change.
4th, statistical method
Statistical analysis is carried out to data with spss softwares.
2nd, result and analysis
1st, laying rate and average daily weight of laying eggs
The each group laying rate of table 1 and weight statistical form of laying eggs
Note：Data shoulder marking-up parent phase go together with the not notable (P of expression difference>0.05), the female different expression differences of shoulder marking-up show
Write (p<0 05).
From the laying rate significant difference (P between upper table, each group<0.05), using liver protection group as highest.Show in daily ration
It is best to the effect of laying rate with liver protection increasing egg oral liquid to add quail of laying eggs.
2nd, the quality of different tests group quail egg
Group quail is laid eggs as seen from Table 2 compares in egg size, and liver protection group, female group of benefit are significantly higher than blank group (P<
0.05)；Hangh unit compares liver protection group and is significantly higher than blank group (P<0.05).Hardness, shell thickness, yolk index compare, respectively
Significant difference (P is not presented between group>0.05).
The quality of the different tests group quail egg of table 2
Note：Data shoulder marking-up parent phase go together with the not notable (P of expression difference>0.05), the female different expression differences of shoulder marking-up show
Write (P<0.05).
3rd, oral liquid intervenes the effect of aged Fatty Liver In Quails
From fig. 6 it can be seen that a：Blank group, it is empty to occur fat not of uniform size in the liver cell of whole lobuli hepatis
Bubble, periphery, hepatic cell cords arrangement disorder are pressed to by liver cell nuclear；b:Liver protection group, liver cell is complete, and liver row leaflet is visible a small amount of small
Fat vacuole；c:Female group of benefit, liver rope understands, lobuli hepatis aligned orderly, it is seen that a small amount of fat vacuole.
Some preferred embodiments of invention have shown and described in described above, but as previously described, it should be understood that invention is not
Form disclosed herein is confined to, is not to be taken as the exclusion to other embodiment, and available for various other combinations, modification
And environment, and can be carried out in the scope of the invention is set forth herein by the technology or knowledge of above-mentioned teaching or association area
Change., then all should be in power appended by invention and the change and change that those skilled in the art are carried out do not depart from the spirit and scope of invention
In the protection domain that profit requires.
Claims (8)
1. one kind is laid eggs, quail increases egg oral liquid with liver protection, it is characterised in that is made up of essentially according to mass parts following components：Mattress
Old 4 parts -8 parts, 4 parts -8 parts of radix pseudostellariae, 2 parts -6 parts of barrenwort, mountain scissors grass 2 parts -6 parts, 2 parts -6 parts of rainbow conk, 1 part -4 of geranium wilfordii
Part.
2. a kind of quail of laying eggs increases the preparation method of egg oral liquid with liver protection, it is characterised in that comprises the following steps：
Step 1, weigh：Following components is weighed according to mass parts：4 parts -8 parts of oriental wormwood, 4 parts -8 parts of radix pseudostellariae, 2 part -6 of barrenwort
Part, 2 parts -6 parts of mountain scissors grass, 2 parts -6 parts of rainbow conk, 1 part -4 parts of geranium wilfordii；
Step 2, by load weighted each component distilled water immersion, carry out decoction processing；Treat that decoction cools down after the completion of decocting every time,
Filtered with funnel, the filtrate collected twice carries out centrifugal treating, discards bottom residues, collects supernatant liquor；
Step 3, supernatant liquor is carried out to concentration, add ethanol after solution to be concentrated cooling thereto and carry out alcohol precipitation, side adds
Ethanol side is stirred, and is subsequently placed in 3 DEG C of refrigerators and is stood one day, is taken out and is stood liquid, carries out filtration treatment, reclaims the second in filtrate
Alcohol；
Step 4, the decoction after recovery ethanol is taken out, add distilled water and sodium benzoate and benzoic acid thereto, be prepared
Decoction；Liquid PH value is adjusted with NaOH, made decoction is dispensed, is sterilized, quail of laying eggs is prepared and increases egg mouth with liver protection
Take liquid.
3. preparation method according to claim 2, it is characterised in that the soak time in the step 2 is 15-45min,
The solid-liquid ratio of decoction is 1:12-1:20, decoct 2 times altogether, decoct 1-2h every time.
4. preparation method according to claim 2, it is characterised in that the centrifugation time in the step 2 is 8-12min,
Centrifugal rotational speed is 2000 revs/min.
5. preparation method according to claim 2, it is characterised in that the volumetric concentration of the ethanol in the step 3 is
50%-80%.
6. preparation method according to claim 2, it is characterised in that the liquor strength after concentration in the step 3 is
1.02-1.05g/mL。
7. preparation method according to claim 2, it is characterised in that medicine liquid volume total amount and step 1 in the step 4
The ratio between middle each component quality total amount is 1:1, sodium benzoate is equal with benzoic acid addition, sodium benzoate and each component in step 1
The mass ratio of quality total amount is 1:280.
8. preparation method according to claim 2, it is characterised in that the mass concentration of the NaOH in the step 4 is
0.2%, liquid PH value is 5~7.
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104083510A (en) * | 2014-07-16 | 2014-10-08 | 江西中成中药原料有限公司 | Liver-protecting granule for poultry and preparation method thereof |
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2017
- 2017-12-05 CN CN201711268328.1A patent/CN107823255A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104083510A (en) * | 2014-07-16 | 2014-10-08 | 江西中成中药原料有限公司 | Liver-protecting granule for poultry and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 曹华赋，等: "脂肪肝出血综合征的发病原因、机理及其防制", 《中国农禽》 * |
| 荆所义，等: "《新编畜禽土单验方3000例》", 31 July 2013, 中原农民出版社 * |
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Application publication date: 20180323 |