CN107822751A - Artery medicine elution bracket based on 3D printing technique and preparation method thereof - Google Patents
Artery medicine elution bracket based on 3D printing technique and preparation method thereof Download PDFInfo
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- CN107822751A CN107822751A CN201711006910.0A CN201711006910A CN107822751A CN 107822751 A CN107822751 A CN 107822751A CN 201711006910 A CN201711006910 A CN 201711006910A CN 107822751 A CN107822751 A CN 107822751A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y10/00—Processes of additive manufacturing
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y80/00—Products made by additive manufacturing
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- Chemical & Material Sciences (AREA)
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- Animal Behavior & Ethology (AREA)
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- Materials Engineering (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- General Health & Medical Sciences (AREA)
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- Medicinal Chemistry (AREA)
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- Vascular Medicine (AREA)
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Abstract
The present invention relates to a kind of stent technology, discloses a kind of artery medicine elution bracket based on 3D printing technique and preparation method thereof.The support includes multiple rack beams, and the rack body material is metal material；Seen on the support beam section, include the load medicine body of solid structure and loose structure, carry medicine body and be located at the support towards the side of vascular wall, the loose structure for carrying medicine body and including the superficial layer and inside of outer surface, the superficial layer has multiple release apertures, and the rack body is integrally formed with 3D printing technique.The application of the support can be avoided effectively because support defective workmanship triggers ISR and thrombus in stents.3D printing technique can realize that backbone metal loose structure designs, and can complete internal stent and carry opening one's minds for medicine.
Description
Technical field
This invention relates generally to a kind of stent technology, in particular to a kind of new based on 3D printing
Artery medicine elution bracket of technology and preparation method thereof.
Background technology
From 1987, since intravascular metallic support is used for coronary artery by uncommon lattice water (Sigwart) etc. first, to control
Treat blood vessel blockage disease and provide good approach, but In-stent Restenosis and thrombus in stents are always to influence warp
The main reason for skin percutaneous coronary intervention (PCI) curative effect.In-stent Restenosis main mechanism is the increasing of endangium
Raw and vessel endothelialisation delay, therefore, preventing and treating in-stent restenosis are chiefly to facilitate the quick reparation of blood vessel endothelium, suppress flat
The hyper-proliferative of sliding myocyte.
Current clinically widely used coronary artery medicinal FirebirdTM (DES) is by being coated in metal support surface
High molecular polymer carry medicine, after support inserts vessel inner lesion position, pass through elution in medicine autohemagglutination compound coating
Mode controlledly discharges to vascular wall tissue and plays biological effect.
The production technology of conventional stent, is had main steps that, first prepares a metal tube, and hollow out laser is carried out to metal tube surface
Engraving, to form supporting structure, is cut into required length again afterwards, finally forms medication coat on surface.
First, laser engraving technique cannot be guaranteed the precision of microstructure, and the attachment stability of medication coat is big
Hidden danger.After support is discharged by balloon expandable, the medication coat on top layer, which is easily disintegrated, to come off, and can cause its uneven distribution and release
Put.Because the permanent polymer coating as pharmaceutical carrier can not be absorbed by the body, it has long-term chronic pro-inflammatory effect and cause
Bolt acts on.And traditional cated rack surface is very rough, implants, current potential, microthrombus locally can produced.
Can endotheliosis be promoted to cause ISR above.
Above- mentioned information is only used for strengthening the understanding of the background to the present invention, therefore it disclosed in the background section
It can include not forming the information to prior art known to persons of ordinary skill in the art.
The content of the invention
A primary object of the present invention is at least one defect for overcoming above-mentioned prior art, there is provided one kind can avoid
Because support defective workmanship triggers the artery medicine elution bracket and its system based on 3D printing technique of ISR and thrombus in stents
Preparation Method.
Another main purpose of the present invention is at least one defect for overcoming above-mentioned prior art, there is provided one kind can be kept away
Exempt from because support defective workmanship triggers the system of the artery medicine elution bracket based on 3D printing technique of ISR and thrombus in stents
Preparation Method.
For achieving the above object, the present invention adopts the following technical scheme that：
According to an aspect of the invention, there is provided a kind of artery medicine elution bracket based on 3D printing technique, including
Multiple rack beams, the rack beams material are metal material；Include structure at least partly described support beam section with carrying medicine
Body, the load medicine body is located at the support includes superficial layer and the inside of outer surface towards the side of vascular wall, the medicine body that carries
Loose structure, the superficial layer has multiple release apertures, and the rack body is integrally formed with 3D printing technique；It is described porous
Structure includes multiple walls and multiple holes, being interconnected between each hole.
According to an embodiment of the present invention, the loose structure is spongy, honeycomb or cell shape loose structure.
According to an embodiment of the present invention, wherein the rack beams include ring beam and longitudinally connected beam, the ring
Beam is expandable shaped form；The longitudinal beam is connected between each ring beam.
According to an embodiment of the present invention, wherein containing resistant activity medicine, the active medicine in the loose structure
Including special capture endothelial progenitor cells antibody drug, anti-smooth muscle cell proliferation medicine.
According to an embodiment of the present invention, wherein the rack body material is cochrome, titanium alloy, medical 316L
Steel, cobalt-nickel alloy or platinum.
According to an embodiment of the present invention, wherein the ring beam of the rack body and longitudinally connected beam surface are light
Sliding cambered surface or curved surface.
According to an embodiment of the present invention, wherein the rack body is manufactured with laser gain material, the porous knot
The porosity of structure is between 25% to 80%；The ratio of the thickness of the superficial layer and the loose structure radius is 1/5 to 1/2
Between.
According to an embodiment of the present invention, wherein the ring beam of the rack body and longitudinally connected beam diameter are 70
To between 150 microns.
According to an embodiment of the present invention, the structure is solid construction, and the diameter of the structure is more than 50-60
μm。
According to an embodiment of the present invention, the diameter for carrying medicine body is more than 10 μm, and the surface layer porosity is less than
The porosity of the loose structure.
According to another aspect of the present invention, there is provided a kind of preparation side of the artery medicine elution bracket based on 3D printing technique
Method, mainly including step：
User's vascular pattern is established using imageological examination；
The model structure of FirebirdTM is determined according to user's vascular pattern；
According to the model structure of FirebirdTM, the rack beams of FirebirdTM are integrally formed with 3D printing technique；
Include structure on the support beam section and be located at the support towards vascular wall with carrying medicine body, the load medicine body
Side, the loose structure for carrying medicine body and including the superficial layer and inside of outer surface, the superficial layer have multiple release windows,
The loose structure includes multiple walls and multiple holes, being interconnected between each hole.
According to an embodiment of the present invention, the rack beams are included in the superficial layer of outer surface and the porous knot of inside
Structure, the rack body are integrally formed with 3D printing technique；The superficial layer has one or more release windows, the release
Window is located at the rack body towards the side of vascular wall；The loose structure is honeycomb or honeycomb cell structure, including multiple walls
With multiple holes, it is interconnected between each hole.
According to an embodiment of the present invention, wherein the rack body after shaping is immersed in resistant activity drug solution
In, absorption medicine enters the loose structure.
As shown from the above technical solution, artery medicine elution bracket and preparation method of the invention based on 3D printing technique
The advantages of and good effect be：
Rack body carries medicine body with loose structure using solid construction body and integrally coordinated, it is ensured that architectural characteristic meets branch
Frame demand, while medicine can also be carried realizing.When support is immersed in drug solution, medicine can be absorbed by saturation absorption principle
Thing simultaneously stores.After in stenter to implant body, medicine can slowly be discharged by osmosis, it is not necessary to polymer coating.Due to more
Pore structure, there is more preferable compliance and ductility.Rack beams have micropore and internal transportation in the side being bonded with vascular wall,
Blood vessel endothelium is directly entered after insoluble drug release.The side of rack beams tube chamber and contacting blood does not have micropore, avoids medicine by blood
Liquid washes away, invalid loss.
The laser-engraving technique of conventional stent is not avoided that top layer carries the design of medicine.But 3D printing technique can realize branch
Frame Structure of metal center designs, and can complete internal stent and carry opening one's minds for medicine.Cobalt chromium used in coronary stent at present
Alloy, platinum evanohm, 316L steel etc., which have, is available for the metal dust for realizing 3D printing.
Conventional stent carries out laser engraving on steel pipe, and therefore, support girder is column shape.Microstructure does not meet blood vessel
The shape of wall arc.3D printing technique can realize the cylindrical-shaped structure design of support girder.Curved surfaces are bonded more with blood vessel
Closely.Ability by tortuous lesion is stronger.
Brief description of the drawings
Consider following the following detailed description of the embodiment of the present invention in conjunction with the accompanying drawings, various targets of the invention,
Feature and advantage will become apparent.Accompanying drawing is only the exemplary diagram of the present invention, is not necessarily drawn to scale.
In the accompanying drawings, same reference represents same or similar part all the time.Wherein：
Fig. 1 is a kind of artery medicine elution bracket based on 3D printing technique according to an illustrative embodiments
Structural representation.
Fig. 2 is a kind of artery medicine elution bracket based on 3D printing technique according to an illustrative embodiments
Girder construction close-up schematic view.
Fig. 3 is that a kind of artery medicine elution bracket based on 3D printing technique according to an illustrative embodiments should
For endovascular partial cutaway schematic.
Fig. 4 is a kind of artery medicine elution bracket based on 3D printing technique according to an illustrative embodiments
Beam body partial cross section structural representation.
Fig. 5 is a kind of artery medicine elution bracket based on 3D printing technique according to an illustrative embodiments
Contraction state structural representation.
Fig. 6 is a kind of artery medicine elution bracket based on 3D printing technique according to an illustrative embodiments
Open configuration structural representation.
Fig. 7 is a kind of artery medicine elution bracket based on 3D printing technique according to an illustrative embodiments
Girder construction close-up schematic view.
Embodiment
Example embodiment is described more fully with referring now to accompanying drawing.However, example embodiment can be with a variety of shapes
Formula is implemented, and is not understood as limited to embodiment set forth herein；On the contrary, these embodiments are provided so that the present invention will
Fully and completely, and by the design of example embodiment comprehensively it is communicated to those skilled in the art.Identical accompanying drawing in figure
Mark represents same or similar structure, thus will omit their detailed description.
The embodiment of the present invention provides a kind of artery medicine elution bracket based on 3D printing technique, certainly, art technology
Personnel should be understood that this support technology can also apply transformations to angiocarpy, peripheral vascular, nerve trachea, enteron aisle, bile duct,
Urethra and Bone Defect Repari/reconstruction application etc..
The artery medicine elution bracket based on 3D printing technique of the embodiment of the present invention, support global design are expandable
Tubulose, using being shaped after balloon expandable.Here it is by taking coronary artery as an example, selection is carried out overall using 3D forming techniques
Shaping, the individual coronary artery profile that can be obtained according to imageological examination, 3D forming techniques is used further directed to property
Support is made, so support selection is the tubulose of matching coronary artery profile, can be more using being shaped after balloon expandable
Adaptability support blood vessels well.
For example, Fig. 1 is a kind of artery medicine based on 3D printing technique according to an illustrative embodiments
The structural representation of FirebirdTM.As illustrated, support 1 mainly includes multiple rack beams, rack beams can distinguish ring beam 11 with
Longitudinally connected beam 12, the shape of ring beam 11 and longitudinal beam 12 can be selected for expandable shaped form, such as in saw, sawtooth
Or sinusoidal wave structure, can also be that ring beam 11 is expandable shaped form.Ring beam 11 surrounds a ring on ring
Shape, and longitudinal beam 12 is connected between each ring beam.Mode according to an embodiment of the present, the rack body
Ring beam and longitudinally connected beam diameter are controlled between 70 to 150 microns.
Support 1 can deliver to blood vessel affected area in a contracted state, afterwards, balloon expandable be utilized in the center cavity of support 1
After carry out shape adaptability support blood vessels, expansion the shape of after-poppet 1 can be found in shown in Fig. 6.According to an embodiment of the present
Mode, the ring beam 11 of the body of support 1 and the longitudinally connected surface of beam 12 are smooth cambered surface or curved surface.
Fig. 2 is a kind of artery medicine elution bracket based on 3D printing technique according to an illustrative embodiments
Girder construction close-up schematic view, Fig. 4 are a kind of dynamic based on 3D printing technique according to an illustrative embodiments
The beam body partial cross section structural representation of arteries and veins bracket for eluting medicament.Fig. 7 is a kind of base according to an illustrative embodiments
In the girder construction close-up schematic view of the artery medicine elution bracket of 3D printing technique.As illustrated, the ring beam of support 1
Mainly include structure 111 on 11 sections and be located at support 1 towards the side of vascular wall 2 with carrying medicine body 112, the load medicine body 112,
The loose structure of superficial layer 113 and inside of the medicine body 112 including outer surface is carried, superficial layer 113 has multiple release apertures 114, released
Discharge hole 114 connects with the loose structure of inside.The selection of the part of structure 111 is solid close-shaped, in order to provide abundance
Rigidity and toughness.The diameter selection of the structure 111 of metal material is more than 50-60 μm, and the cross sectional shape of structure 111 may be selected
For circle, ellipse, or circle and the split shape of ellipse shown in figure, the requirement to intensity can be met.Than
Such as：Cobalt-base alloys (including cobalt chromium, cobalt nickel) can be with thinner, for example minimum 50 μm can meet.If 316L steel, most 60 μm with
On can meet.It should be understood of course that the structure of each longitudinal beam 12 can be also configured by said structure, it is,
Each longitudinal beam 12, which can equally configure, carries medicine body structure.
Fig. 3 is that a kind of artery medicine elution bracket based on 3D printing technique according to an illustrative embodiments should
For endovascular partial cutaway schematic, medicine body 112 is carried then primarily to discharging medicine towards vascular wall 2, it can be selected
It is selected as being wrapped in the side of structure 111, and selects to be positioned at the side towards vascular wall 2, in order to directly discharge to vascular wall
Medicine, medicine overflow is reduced, so as to reduce the generation of adverse drug reaction.Here, the shape for carrying medicine body 112 can substantially be in bent moon
Shape so that the main body of drugloading rate is located at the middle part of face vascular wall 2.
Wherein, the loose structure in the embodiment of the present invention, spongy, honeycomb or honeycomb cell structure are may be selected to be, wrapped
Multiple walls and multiple holes are included, are interconnected between each hole.Loose structure may be selected to be unordered and orderly two class, and former structure is such as
Foamed material, and the latter is mainly lattice material.Support rigidity can be improved using disordered structure；According to ordered structure, can protect
Demonstrate,prove the plasticity of support orientation.Selection is connection between each hole in the present embodiment, is continuous unimpeded three-dimensional porous structure, with
It is easy to stable carrier band resistant activity medicine, and release stable in the blood vessel.Loose structure has high specific strength, Gao Bigang
Degree, high tough characteristic, can reduce materials'use, but do not reduce intensity and toughness.
Mode according to an embodiment of the present, rack body are manufactured with laser gain material, carry the porous of medicine body 112
The porosity of structure is selected between 25% to 60%, and the selection of porosity has with the selection for carrying the volume of medicine body 112 and drugloading rate
Close, overall drugloading rate selection controls to be advisable in 1-2 μ g/mm2 (support whole surface area is denominator)；The wherein thickness of superficial layer 113
The ratio of degree and the loose structure radius is between 1/5 to 1/2.
Wherein, the superficial layer 113 for carrying medicine body 112 can have multiple release apertures 114, and release aperture 114 is located at rack body
Towards the side of vascular wall 2；In order to which selectivity discharges resistant activity medicine to vascular wall.The outlet of release aperture 114 is as small as possible,
Ensure the controlled-release profile of medicine, when stent expansion discharges, medicine, which is unlikely to be extruded, to be come.Load can also be realized by 3D printing
The adjustment and change of dose.The big volume calculations drugloading rate of hole can be adjusted by computer to change, and realize that individuation dose controls.
A kind of way of example of the present invention, the selectable molding mode of its medium-height trestle have, and 3D nanometers printer is using high
Fast double-photon optical carving technology, can form ultra micro details.In one more embodiment of the present invention mode, the molding mode of support selection
It is laser gain material manufacture Laser 3D printing, L3DP, mainly including precinct laser sintering (Selective Laser
Sintering, SLS) technology, direct metal laser sintering (Direct Metal Laser Sintering, DMLS), choosing
Area's laser fusion (Selective Laser Melting, SLM) technology, laser near-net-shape (Laser Engineered Net
Shaping, LENS) technology, two-photon 3D photoetching (two-photon 3D lithography) and electron beam selective melting
(Electron Beam Selective Melting, EBSM) technology etc..
A kind of mode according to an embodiment of the present, there is provided artery medicine elution bracket system based on 3D printing technique
Preparation Method, mainly including step：
User's vascular pattern is established using imageological examination；Can be specifically the CT for obtaining target or focus segmental vessels,
MRI image data, or angiogram image data.
The model structure of FirebirdTM is determined according to user's vascular pattern；1 is carried out to it:1 external and internal compositionses three-dimensional reconstruction.
According to the model structure of FirebirdTM, the rack body of FirebirdTM is integrally formed with 3D printing technique.Can root
According to the external and internal compositionses feature of blood vessel, structure suits the support of blood vessel and vascular morphology, and forms three dimensional file；By three Balakrishnans
Part be converted into can 3D printing associated documents, select one of above-mentioned cited increasing material manufacturing 3D printing method, carry out 3D printing
Shaping.
Mode according to an embodiment of the present, in rack forming mode, individual is obtained according to imageological examination first
Coronary artery profile, imageological examination includes coronarography, either intravascular ultrasound or optical coherence tomography
The intracavitary image technologies such as scanning.Then the 3D models of support are established according to the blood vessel profile of individual.Then by the 3D models of support
Multiple two-dimensional slice data are decomposed into successively along length of vessel direction, and the thickness of each two-dimensional slice shaping can be controlled in 80-100 μm
Between.Successively it is molded using feed metal powder as raw material using 3D printing technique, while is completed using laser beam or electron beam afterwards
Metal fuses, and ultimately forms the supporting structure in above-described embodiment.3D printing technique selection therein uses SLM selective lasers
Fusion technology and relevant device.
According to another way of example of the present invention, in rack forming mode, obtained first according to imageological examination
The coronary artery profile of individual, imageological examination include coronarography, either intravascular ultrasound or optical coherence
The intracavitary image technology such as tomoscan.Then the 3D models of support are established according to the blood vessel profile of individual.Afterwards, along each ring
The axial direction of beam 11 is decomposed into multiple two-dimensional slice data, and the thickness of each two-dimensional slice shaping is can be controlled between 80-100 μm.It
Successively it is molded using feed metal powder as raw material using 3D printing technique afterwards, while completes metal using laser beam or electron beam and melt
Connect, ultimately form with structure 111 and the multiple ring beams 11 for carrying medicine body 112.The head and the tail tie point of ring beam 11 may be selected not
Design carries medicine body 112, is connected from beginning to end in order to complete ring beam 11.This forming process, type direction is may be controlled to shape simultaneously
Curvilinear shape of the cyclization to beam 11.Multiple longitudinally connected beams 12 are formed using respective material wire afterwards, and are successively led to
Cross the technology that is soldered or welded and connect adjacent ring to beam 11.Ultimately form the supporting structure in above-described embodiment.Longitudinally connected beam 12
Connection Step still elect to utilize 3D printing technique, lift shaping just with the preforming wire rod of longitudinally connected beam 12 is supplied
Speed, main forming action is in tie point.Such a molding mode, due to ring beam 11 and tie-beam 12 can with preforming, so
There is the advantage that equipment investment is small, shaping speed is fast in actual use.
According to another way of example of the present invention, in rack forming mode, obtained first according to imageological examination
The coronary artery profile of individual, imageological examination include coronarography, either intravascular ultrasound or optical coherence
The intracavitary image technology such as tomoscan.After or before, utilize the wire rod of solid metal preparation structure body 111, the wire rod of structure 111
Section meets shape exemplified by Fig. 4；Prepared using porous material metal and carry the wire rod of medicine body 112, carried the wire rod section of medicine body 112 and meet
Shape exemplified by Fig. 4；Merge the wire rod of Supply Structure body 111 with carrying the wire rod of medicine body 112 using 3D printing technique afterwards, by Fig. 4 institutes
The connection that way of example carries out progressively combines, and combination technology can use the technology that is soldered or welded of laser or electron beam to realize, most
End form is into structure 111 and the multiple ring beams 11 for carrying medicine body 112.Laser or electricity may be selected in the head and the tail tie point of ring beam 11
Beamlet is soldered or welded technology realization.This forming process, may be controlled to type direction with and meanwhile form the curve of ring beam 11
Shape shape.Multiple longitudinally connected beams 12 are formed using respective material wire afterwards, and successively by being soldered or welded technology
Connect adjacent ring beam 11.Ultimately form the supporting structure in above-described embodiment.The connection of ring beam 11 and longitudinally connected beam 12
Step still elects to utilize 3D printing technique, just with supply the longitudinally connected wire rod of beam 12 lifting of preforming ring beam 11 into
Type speed, main forming action is in tie point.
Carrying the wire rod of medicine body 112 in above-described embodiment can be with the existing POROUS TITANIUM of Selection utilization or porous titanium alloy process technology shape
Into.Above-mentioned forming step can realize Automated condtrol by area of computer aided, utilize the support 3D model cootrols pre-established
Final shape.
Such a molding mode, because structure 111, load medicine body 112 and tie-beam 12 can be preforming by traditional approach,
The connection and shaping between main material are realized merely with 3D forming techniques, thus actual use in have cost is low, equipment investment is small, into
The fireballing advantage of type.
Mode according to an embodiment of the present, before in one embodiment, structure 111 and carry between medicine body 112
Interface arrangment can also be reserved, the combination of the two is completed by the riveting after clamping or clamping, welding.In this way, after the two combination
Bending on demand and deformation, afterwards each part welding can be passed through
Also, because support main material is preforming using traditional approach, the requirement of the various performance parameters of support (for example supports
Power, toughness) effective management and control can be carried out by the material tests before shaping, the optimization of quality and efficiency can be accomplished, can be stable
Control the support quality after final molding.
Mode according to an embodiment of the present, the rack body after shaping are immersed in resistant activity drug solution, are inhaled
Attached medicine enters the loose structure.Mode according to an embodiment of the present, the active medicine are included in special capture
Skin progenitor cells antibody drug, anti-smooth muscle cell proliferation medicine.Various anti-restenosis compound, including antiproliferative can specifically be applied
Medicine, such as taxol (taxol), adriamycin, rapamycin etc..
In inventive embodiments, support Design drugloading rate 1-2 μ g/mm2, select to carry medicine in contact vascular wall side.Really hair
Wave effect is the medicine that side is bonded with vascular wall in fact.Support Design drugloading rate is according to 1-2 μ g/mm2Calculate, carry medicine body
The selection of 112 maximum gauges is 6-10 μm.
It should be understood of course that can not only reach the effect of Drug controlled release using said structure feature,
Sustained release preparation (sustained-release preparations) or controlled release preparation (controlled- can be combined with
Release preparations) technology, mixed with medicine to reach Drug controlled release.
Fig. 5 is a kind of artery medicine elution bracket based on 3D printing technique according to an illustrative embodiments
Contraction state structural representation.Fig. 6 is a kind of artery medicine based on 3D printing technique according to an illustrative embodiments
The open configuration structural representation of thing FirebirdTM.As illustrated, using solid construction body and porous load medicine body respective outer side edges,
It can ensure that architectural characteristic meets support demand, while medicine can also be carried realizing., can be with when support is immersed in drug solution
Absorb the drug and store by saturation absorption principle.After in stenter to implant body, medicine can slowly be discharged by osmosis, no
Need polymer coating.Due to loose structure, there is more preferable compliance and ductility.Rack beams are in one be bonded with vascular wall
There are micropore and internal transportation in side, and blood vessel endothelium is directly entered after insoluble drug release.The side of rack beams tube chamber and contacting blood does not have
There is micropore, avoid medicine from washing away by blood, invalid loss.
According to the another embodiment mode of the present invention, there is provided (overall structure does not illustrate another supporting structure embodiment
Accompanying drawing), support is with the tubular construction of continuous sine wave shape helical arrangement, similar to the integral form of helical spring, but area
It is not to replace the linear wire rod structure of spring by continuous sine wave structure, simultaneously as be that connection arranges, the sine of adjacent turn
Top in waveform shape (equivalent to an one ring beam 11 of circle) is neighbouring, will can mutually be interconnected at the top of neighbouring sine wave by selectivity
Connect, to reach the effect of longitudinally connected beam 12, such as along the multiple sine waves in hand of spiral interval by merging welding completion connection.
This structure stand makes support reach preferable adherent effect.Longitudinal compression can be reduced simultaneously, is scratched with reducing.Apparatus passes through support
Shi Fasheng scratches probability can be greatly reduced.Can also be more convenient for intravascular conveying.
In a kind of this molding mode embodiment of the support of structure, the individual hat that can be obtained first according to imageological examination
Shape arteries profile, imageological examination include coronarography, either intravascular ultrasound or optical coherence tomography
Etc. intracavitary image technology.After or before, using the wire rod of solid metal preparation structure body 111, the wire rod section of structure 111 meets
Shape exemplified by Fig. 4；Prepared using porous material metal and carry the wire rod of medicine body 112, carried the wire rod section of medicine body 112 and meet shown in Fig. 4
Example shape；Merge the wire rod of Supply Structure body 111 with carrying the wire rod of medicine body 112 using 3D printing technique afterwards, as shown in Figure 4 example mode
The connection carried out progressively combines, and combination technology can use the technology that is soldered or welded of laser or electron beam to realize, ultimately form tool
There is structure 111 with carrying the continuous sine wave base material of medicine body 112, wherein carrying medicine body 112 is integrally located at a side.Afterwards by base
Material, which is spirally wound on a spool, forms cylindrical shape；Finally fusion welding is selectively carried out in neighbouring multiple sinusoidal wave crests.
Ultimately form the supporting structure in above-described embodiment.Can lift shaping speed using the base material wire rod for supplying preforming, mainly into
Type is acted in tie point.
In a kind of molding mode another kind embodiment of this support of structure, what can be obtained first according to imageological examination is individual
The coronary artery profile of body, imageological examination include coronarography, and either intravascular ultrasound or optical coherence break
The intracavitary image technologies such as layer scanning.After or before, using the wire rod of solid metal preparation structure body 111, the wire rod of structure 111 is cut
Face meets the analogous shape exemplified by Fig. 4；The wire rod of structure 111 is prepared as continuous sine wave base material afterwards, this base material can
To be linear.Prepared afterwards using porous material metal using 3D printing technique on base material and carry medicine body 112, carry medicine body 112
Wire rod section, which may be selected to be, meets shape exemplified by Fig. 4；The step for 3D printing technique selectable range it is wider because before
It is optional in the step of preforming base material has formed the structural parameters such as support force needed for support and toughness, and 3D printing carries medicine body 112
Select in the form of whole face or linear array is carried out, the generation of new material is completed based on the faying face of structure 111.By Fig. 4
The connection that exemplified mode carries out progressively combines, and ultimately forms with structure 111 and the continuous sine wave base for carrying medicine body 112
Material, wherein carrying medicine body 112 is integrally located at a side.It is spirally wound on afterwards with base material on a spool and forms cylindrical shape；Most
Afterwards fusion welding is selectively carried out in neighbouring multiple sinusoidal wave crests.Ultimately form the supporting structure in above-described embodiment.Utilize
Shaping speed can be lifted by supplying preforming base material wire rod, and structure 111 can be improved with carrying the knot of medicine body 112 using 3D printing technique
Close intensity and molding effect.
Spool described in previous embodiment can be prepared according to the coronary artery profile of individual, and spool profile can
To correspond to the individual intravascular spatial form after equal proportion inside contracts to axle center, the ratio that equal proportion inside contracts to axle center can basis
Counter push away of the magnification of support draws.It can be prepared by 3D printing technique with gypsum, resin or plastic or other material.With this, energy
Low cost is made to the support of adaptation individual demand.Certainly, it can also be put with this and be combined with ordinary stent technology of preparing, according to individual
The blood vessel profile fast custom support of body.Or the implementation of this spool, it can be combined with foregoing several embodiments, with
A kind of rapid forming mold is provided.
As seen from the above embodiment, in the technical thought of the embodiment of the present invention, it is also believed that in support preparation method, can
With including preformed substrates step and in-place forming step, preformed substrates step can carry out large-scale production in factory, and scene into
Type step can be according to individual imageological examination and targetedly therapeutic scheme carries out flexible customization.Preformed substrates step can be extremely
The structure of major general's support ring beam is partially completed, or even will be prepared comprising structure with carrying the complete ring beam base material of medicine body
Complete, the step in strict quality control, branch can be carried out to support base material by the production management of specification and finished product quality inspection
The support force and toughness index of frame can thereby guarantee that, can effectively control the uniformity of final products, and the expection for the treatment of can
Control property.And before actual use, can be according to actual conditions, with a small amount of forming step, you can go out institute using base material fast custom
The support of form or length is needed, the contradictory problems between can perfectly solving quality and customizing.
The laser-engraving technique of conventional stent is not avoided that top layer carries the design of medicine.But 3D printing technique can realize branch
Frame Structure of metal center designs, and can complete internal stent and carry opening one's minds for medicine.Cobalt chromium used in coronary stent at present
Alloy, platinum evanohm, magnesium alloy, 316L steel etc., which have, is available for the metal dust for realizing 3D printing.
Conventional stent carries out laser engraving on steel pipe, and therefore, support girder is column shape.Microstructure does not meet blood vessel
The shape of wall arc.3D printing technique can realize the cylindrical-shaped structure design of support girder.Curved surfaces are bonded more with blood vessel
Closely, and this support is stronger by the ability of tortuous lesion.
Conventional stent only has fixed length and width specification, but actually general blood vessel be it is upper it is thick under narrow taper, and have point
Branch.Therefore, it is necessary to which the different support of two diameters connects when treating Long lesion using conventional stent, which part is overlapping.And
When handling bifurcated lesions, it is also desirable to which two supports intersect implantation.This all unavoidably causes support overlapping, increases narrow again in support
Narrow chance.Using the support of the embodiment of the present invention, model can be established by blood vessel image data, is directly printed complete with blood vessel
The support and special form of bifurcation matched entirely.The complicated art formula for avoiding the overlapping and multilayer bracket of support from being implanted into.For small part
The blood vessel of super-large diameter, or the blood vessel of steric configuration extremely complexity can realize " customized " size and spatial form.
According to length of lesion print carriage, multiple supports are needed to connect unlike conventional stent processing Long lesion, can be real
It is now overlapping without metal, stenter to implant number can be reduced.Thickness can be printed not according to the thin physiological structure in the thick distal end of blood vessel near-end
Homogeneous support.Support is set more to be matched with blood vessel.For bifurcated lesions, bifurcated stent can be directly printed, it is not necessary to multiple
Miscellaneous double bracket.
Using the support of the embodiment of the present invention, there can be more a wide range of applicable crowd, such as：
Special-shaped blood vessel (Ectasia, drop is very big, altogether dry more bifurcated lesions) or the customization support of super large blood vessel；
Coronary artery, encephalic and peripheral arterial can be applied；
The support of the embodiment of the present invention is thinner, and compliance is more preferable, and soak time is shorter, reduces antiplatelet drug after support
Usage time, drug side-effect can be reduced.
Some currently preferred embodiments of the present invention formula has been illustrated above in association with accompanying drawing.The technical field of the invention it is general
Lead to it will be appreciated by the skilled person that concrete structure and technical process shown in above-mentioned specific embodiment part are only example
Property, and it is nonrestrictive.Moreover, general technical staff of the technical field of the invention can be to described above shown various
Technical characteristic is combined according to various possible modes to form new technical scheme, or carries out other changes, and is all belonged to
Within the scope of the present invention.
Claims (10)
1. a kind of artery medicine elution bracket based on 3D printing technique, including multiple rack beams, the rack beams material is gold
Belong to material；It is located at institute with carrying medicine body, the load medicine body characterized in that, including structure at least partly described support beam section
Support is stated towards the side of vascular wall, the loose structure for carrying medicine body and including the superficial layer and inside of outer surface, the surface
Layer has multiple release apertures, and the rack body is integrally formed with 3D printing technique；The loose structure includes multiple walls and more
Individual hole, it is interconnected between each hole.
2. the artery medicine elution bracket based on 3D printing technique as claimed in claim 1, it is characterised in that the rack beams
Including ring beam and longitudinally connected beam, the ring beam is expandable shaped form；The longitudinal beam is connected to each ring
Between beam.
3. the artery medicine elution bracket based on 3D printing technique as claimed in claim 1, it is characterised in that the porous knot
Contain resistant activity medicine in structure, the active medicine includes special capture endothelial progenitor cells antibody drug or anti-smooth muscle cell increases
Grow medicine.
4. the artery medicine elution bracket based on 3D printing technique as claimed in claim 1, it is characterised in that the rack beams
Material is cochrome, titanium alloy, medical 316L steel, magnesium alloy, cobalt-nickel alloy or platinum.
5. the artery medicine elution bracket based on 3D printing technique as claimed in claim 1, it is characterised in that the porous knot
Structure is spongy, honeycomb or cell shape loose structure.
6. the artery medicine elution bracket based on 3D printing technique as claimed in claim 1, it is characterised in that the rack beams
It is manufactured with laser gain material, the porosity of the loose structure is between 25% to 80%.
7. the artery medicine elution bracket based on 3D printing technique as described in any one of claim 1 to 6, it is characterised in that
The ring beam of the rack beams and longitudinally connected beam diameter are between 70 to 150 microns.
8. the artery medicine elution bracket based on 3D printing technique as described in any one of claim 1 to 6, it is characterised in that
The structure is solid construction, and the diameter of the structure is more than 50-60 μm.
9. the artery medicine elution bracket based on 3D printing technique as described in any one of claim 1 to 6, it is characterised in that
The diameter for carrying medicine body is more than 10 μm, and the surface layer porosity is less than the porosity of the loose structure.
A kind of 10. artery medicine elution bracket preparation method based on 3D printing technique, mainly including step：
User's vascular pattern is established using imageological examination；
The model structure of FirebirdTM is determined according to user's vascular pattern；
According to the model structure of FirebirdTM, the rack beams of FirebirdTM are integrally formed with 3D printing technique；
Include structure on the support beam section and be located at the support towards the one of vascular wall with carrying medicine body, the load medicine body
Side, the loose structure for carrying medicine body and including the superficial layer and inside of outer surface, the superficial layer have multiple release windows, institute
Stating loose structure includes multiple walls and multiple holes, being interconnected between each hole.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201711006910.0A CN107822751A (en) | 2017-10-25 | 2017-10-25 | Artery medicine elution bracket based on 3D printing technique and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201711006910.0A CN107822751A (en) | 2017-10-25 | 2017-10-25 | Artery medicine elution bracket based on 3D printing technique and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109330752A (en) * | 2018-10-22 | 2019-02-15 | 中国人民解放军陆军军医大学第附属医院 | 3D printing intravascular stent |
| WO2023178938A1 (en) * | 2022-03-23 | 2023-09-28 | 苏州卓欣雅科技有限公司 | 3d-printed degradable intravascular stent loaded with salvianolic acid b |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040133270A1 (en) * | 2002-07-08 | 2004-07-08 | Axel Grandt | Drug eluting stent and methods of manufacture |
| TW200840553A (en) * | 2007-04-12 | 2008-10-16 | Jung-Tang Huang | A fabrication method for drug-eluting stent with medicine-compatible filling mechanism |
| CN101779993A (en) * | 2001-09-11 | 2010-07-21 | Xtent公司 | expandable stent |
| CN101874751A (en) * | 2009-04-30 | 2010-11-03 | 复旦大学 | Multi-layer porous scaffold and preparation method thereof |
| CN101884574A (en) * | 2010-06-28 | 2010-11-17 | 河北工业大学 | Method and device for preparing three-dimensional porous support for tissue engineering |
| CN103568326A (en) * | 2012-07-30 | 2014-02-12 | 比亚迪股份有限公司 | Preparation method of intravascular stent, and intravascular stent prepared thereby |
-
2017
- 2017-10-25 CN CN201711006910.0A patent/CN107822751A/en not_active Withdrawn
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101779993A (en) * | 2001-09-11 | 2010-07-21 | Xtent公司 | expandable stent |
| US20040133270A1 (en) * | 2002-07-08 | 2004-07-08 | Axel Grandt | Drug eluting stent and methods of manufacture |
| TW200840553A (en) * | 2007-04-12 | 2008-10-16 | Jung-Tang Huang | A fabrication method for drug-eluting stent with medicine-compatible filling mechanism |
| CN101874751A (en) * | 2009-04-30 | 2010-11-03 | 复旦大学 | Multi-layer porous scaffold and preparation method thereof |
| CN101884574A (en) * | 2010-06-28 | 2010-11-17 | 河北工业大学 | Method and device for preparing three-dimensional porous support for tissue engineering |
| CN103568326A (en) * | 2012-07-30 | 2014-02-12 | 比亚迪股份有限公司 | Preparation method of intravascular stent, and intravascular stent prepared thereby |
Non-Patent Citations (2)
| Title |
|---|
| 孟磊: "《3D打印多孔β-TCP负载PLGA抗结核药物缓释微球复合材料的制备与初步研究》", 《甘肃中医药大学硕士论文》 * |
| 李坤: "《基于三维打印技术的载药抗结核骨支架的构建与特性研究》", 《第二军医大学博士论文》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109330752A (en) * | 2018-10-22 | 2019-02-15 | 中国人民解放军陆军军医大学第附属医院 | 3D printing intravascular stent |
| WO2023178938A1 (en) * | 2022-03-23 | 2023-09-28 | 苏州卓欣雅科技有限公司 | 3d-printed degradable intravascular stent loaded with salvianolic acid b |
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