CN107811658A - Tissue specimen collection and separator - Google Patents

Tissue specimen collection and separator Download PDF

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Publication number
CN107811658A
CN107811658A CN201711075864.XA CN201711075864A CN107811658A CN 107811658 A CN107811658 A CN 107811658A CN 201711075864 A CN201711075864 A CN 201711075864A CN 107811658 A CN107811658 A CN 107811658A
Authority
CN
China
Prior art keywords
bottle
inner core
separator
specimen collection
tissue specimen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201711075864.XA
Other languages
Chinese (zh)
Inventor
双建军
沈正华
李常青
卢栋华
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Micro Tech Nanjing Co Ltd
Original Assignee
Micro Tech Nanjing Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Micro Tech Nanjing Co Ltd filed Critical Micro Tech Nanjing Co Ltd
Priority to CN201711075864.XA priority Critical patent/CN107811658A/en
Priority to PCT/CN2018/076420 priority patent/WO2019085342A1/en
Publication of CN107811658A publication Critical patent/CN107811658A/en
Pending legal-status Critical Current

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0096Casings for storing test samples
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/02Instruments for taking cell samples or for biopsy
    • A61B10/04Endoscopic instruments

Abstract

The present invention provides a kind of tissue specimen collection and separator, including:Bottle, the bottle have the top of the first volume and the bottom of the second volume, are suitable for the bottle cap on the top, and bottle cap has the duct for receiving tissue samples;Circular filter net, the bottom center installed in bottle bottom, the circular filter net has can be from the support column that bottle bottom upwardly extends;At least one inner core is removably mounted on the bottle top, the inner core has multiple side walls and porous bottom surface, the porous bottom surface of the inner core can filter tissue samples, tissue samples is maintained at the top of the bottle, and fluid flows into the bottom of the bottle.

Description

Tissue specimen collection and separator
Technical field
The present invention relates to a kind of tissue specimen collection and separator, particularly a kind of tissue sample with dual filtering functions This collection and separator.
Technical background
With widely using for endoscope, clinician can carry out biological tissue under direct-view by endoscope channel and take Sample, pathology chemical examination is carried out, most direct evidence is provided for medical diagnosis on disease;Clinician can also be by endoscope channel straight Various Minimally Invasive Surgeries are carried out depending on lower.Various dexterous apparatuses carry out all kinds of hands by the endoscope channel patient's diseased region that can go directly Art, safer minimally invasive surgery chance is not only provided to patient, and also mitigate the pain of patient.With the hair of science and technology Exhibition, in order to mitigate patient suffering, the positive less and less direction of external diameter of endoscope is developed, and for the ease of carrying out Minimally Invasive Surgery The positive increasing direction in the pincers road of endoscope is developed.
Tissue specimen collection and separator have applied to clinic at present.Its operation principle is:By tissue specimen collection and The suction tube of separator is connected with aspirator, collects hole and is connected with endoscope channel, under endoscope direct-view, passes through The work of aspirator, the polyp equal samples in sick body is adsorbed onto in sample collection and separator by collecting hole, for Pathological analysis, traditional sample is collected and separator buckles mode up and down using bottle and bottle cap, using single layer filter, is easily made Into maloperation, when collecting hole and being not aligned with collecting basket, it is not drawn into and collects in basket, polyp sample may be by from suction tube Directly aspirate away, and be directly entered waste collection bottle, from without getting biopsy, serious conditions and then controlling for patient can be delayed Treat, so the present invention provides a kind of tissue specimen collection and separator with double filtration, even if can not have collecting hole When basket is collected in alignment, polyp sample will not be also sucked away, so as to provide a kind of safe and reliable tissue specimen collection and separation Device.
The content of the invention
In order to solve deficiency of the prior art, the present invention provides a kind of tissue specimen collection with double filtration and separation Device, it family can be used more easily to take out sample, avoid the loss of sample, there is provided the security reliability of biopsy.
The present invention, which provides a kind of tissue specimen collection and separator, the tissue specimen collection and separator, to be included: Bottle, the bottle have the top of the first volume and the bottom of the second volume;It is suitable for the bottle cap on the top, bottle cap has Receive the duct of tissue samples;Circular filter net, the bottom center installed in bottle bottom, the circular filter net has can be from The hollow support post that bottle bottom upwardly extends, between the support column and the inner vessel surface, at least one inner core can The bottle top is releasably arranged on, the inner core has multiple side walls and a porous bottom surface, more bottom holes of the inner core Face can filter tissue samples, tissue samples is maintained at the top of the volume of bottle first, and fluid flows into the bottle The bottom of second volume.
In one embodiment, the inner surface of the bottle also has step-like protrusion, and the inner core can be placed on this In step-like protrusion.
In one embodiment, the inner core can also have two recesses, respectively the convex with inner vessel surface and branch The convex screens of the outer surface of dagger is fixed.
In one embodiment, the porous bottom surface of the inner core and the circular filter net are also designed to different holes Footpath size, realize different sample separating capacities.Preferably, the aperture of the porous bottom surface structure of the inner core is more than the annular The aperture of screen pack.
In one embodiment, the inner core can be one or more, and independently of one another.Preferably, the inner core is also Can be 4, and independently of one another.
In one embodiment, the bottle cap also has a suction tube, and the suction tube can be from the surface of bottle cap to downward Extend into bottle, so as to form a suction channel.
In one embodiment, also there is positioning instruction, on the one hand, the positioning instruction can be located at institute on the bottle cap State on bottle cap edge, i.e., there is prominent positioning to indicate on described bottle cap edge, protrusion positioning instruction can be colored three Angle indicates that on the other hand, the positioning instruction can be located at below the bottle cap, i.e., it is fan-shaped raised fixed to have below described bottle cap Bit architecture.
Beneficial effect:
Tissue specimen collection and separator provided by the invention, the porous bottom surface and circular filter net of its inner core can play The effect of double filtration, separated so as to preferably carry out tissue samples with fluid, when tissue samples enter inner core, now inner core Porous bottom surface carries out first layer filtering, and under normal circumstances, tissue samples will be stored in inner core, and fluid is by circular filter net the It is sucked away after two layers of filtering by suction channel, even if under special circumstances, tissue samples do not enter into inner core and direct Into in bottle, at this moment due to the presence of circular filter net, also tissue samples can be avoided to be siphoned away by mistake, so as to reduce the wind of operation Danger.
Tissue specimen collection and separator provided by the invention, inner core are removably mounted on bottle top, and annular Screen pack is arranged on the bottom center of bottle bottom, and the two has larger space spacing, therefore it is more to greatly reduce inner core The problem of being blocked between bottom hole face and the filtering hole of circular filter net because distance closely adheres to foul very much.
Brief description of the drawings
Fig. 1 is tissue specimen collection and separator general profile stereogram
Fig. 2 is tissue specimen collection and separator explosive view
Fig. 3 is tissue specimen collection and separator package assembly profile
Fig. 4 A are the bottle figures for being provided with inner core
Fig. 4 B are core arrangement figures
Fig. 5 is that inner core fixes top view with bottle
Fig. 6 A are the Bottle cap structure schematic diagrames for having at edge prominent positioning instruction
Fig. 6 B are the Bottle cap structure schematic diagrames for having a raised location structure of sector in lower section
1st, flexible pipe, 2, bottle cap, 3, inner core, 4, support column, 5, bottle, 6, collect hole, 7, suction tube, 8, circular filter net, 9th, step-like protrusion, 10, prominent positioning instruction, 11, fan-shaped raised location structure, 21, innercore sidewall, 22, innercore sidewall, 23, Outer arcuate wall, 24, internal arcwall, 25, porous bottom surface, 31, the recess 32 on internal arcwall, support outer surface of column it is convex Place, 33, the recess on outer arcuate wall, 34, the convex of inner vessel surface, 35, recessed
Embodiment
In order to make the purpose , technical scheme and advantage of the present invention be clearer, it is right below in conjunction with drawings and Examples The present invention is further elaborated.It should be appreciated that specific embodiment described herein is only to explain the present invention, not For limiting the present invention.
As shown in figure 1, the tissue specimen collection and separator of the present invention can be used to collect tissue samples, it includes bottle 5 and bottle cap 2, the bottle cap 2 is covered on removably and rotatably on bottle 5.Preferably, the bottle 5 can be hollow cylinder Body, and there is a rounded bottom surface, the bottle 5 has the top of the first volume and the bottom of the second volume, the top of the bottle 5 Can have identical diameter or different diameters with the bottom of bottle 5, it is preferable that the diameter on the top of bottle 5 is more than under bottle 5 Portion.Preferably, the bottle cap 2 can using friction fastener or screw thread tighten etc. be adapted to by the way of cover with bottle 5, bottle cap 2 and bottle Cooperation between body 5 needs certain air-tightness requirement, and 20Kpa negative pressure can be at least reached when closing and aspirating, and negative at this Pressure, bottle 5 can still rotate relative to bottle cap 2.
As shown in Figure 2-5, the bottle cap 2 has a suction tube 7, and the suction tube 7 can extend downwardly from the upper surface of bottle cap 2 Into in bottle 5, so as to form a suction channel.On the bottle cap 2 also have one collection hole 6, flexible pipe 1 can by with collection Hole 6 carries out pipeline connection, so as to which bottle cap 2 to be connected to form collection channel with endoscope.
Circular filter net 8 is arranged on the rounded bottom surface center of the bottom of bottle 5, and multiple holes of the circular filter net can rise The effect of tissue samples is filtered, it has the hollow support post 4 that the lower section of bottle cap 2 is extended upwardly to from the bottom of bottle 5, forms fluid stream Circulation passage, support column 4 can be hollow cylinder, and when bottle cap 2 is covered on 5 top of bottle, suction tube 7 is located at the branch in bottle 5 In dagger and apart from the bottom a certain distance of bottle 5, so when being aspirated by external suction means, in bottle 5 Fluid can pass through the suction channel that circular filter net 8 is formed subsequently into suction tube 7 and be sucked out, and then the mesh filtered 's.
As shown in Figure 2-5, the inner surface on the top of bottle 5 can have step-like protrusion 9, in support column 4 and the top of bottle 5 Between inner surface, one or more inner cores 3 are removably mounted on the step-like protrusion 9 of the upper inside surface of bottle 5 independently of one another On, it is preferable that all inner cores 3 accommodated in bottle 5 can be of the same size with volume or different size and volume, it is excellent Selection of land, all inner cores 3 are of the same size and volume.The inner core 3 can have multiple side walls 21,22,23,24 and one porous Bottom surface 25, the porous bottom surface of inner core 3 can filter tissue samples, tissue samples is maintained at the top of bottle 5, and fluid flows into bottle The bottom of body 5.Specifically, inner core 3 includes the side wall 21,22 two relatively at an angle, in the outer of two side walls 21,22 The outer arcuate wall 23 extended between edge, and the inside arcwall 24 extended between the inward flange of two side walls 21,22, Close to the inner surface of bottle 5, and the shape of outer arcuate wall 23 and the inner surface of bottle 5 match the outer arcuate wall 23, interior Portion's arcwall 24 matches close to the outer surface of support column 4, the shape of internal arcwall 24 and the outer surface of support column 4, inner core 3 Angle between two side walls 21,22 can adjust according to the quantity that inner core 3 is accommodated in bottle 5, and two side walls 21,22 are from bottle 5 The bottom on top extends vertically up to the position of neighbouring bottle cap 2, the bottom of two side walls 21,22, and the He of outer arcuate wall 23 The bottom of internal arcwall 24 is connected to form inner core porous bottom surface 25, there is the filtering that can be played a role in filtering on porous bottom surface 25 Hole.When bottle cap 2 rotates relative to bottle 5, the collection hole 6 on bottle cap 2 can be made to be placed in the top of an inner core 3, it is outside Aspirator is aspirated by suction tube 7, and in the containment system of closing, tissue samples are directly pumped out from biopsy duct Come, by flexible pipe, then fallen into via collection hole 6 in inner core 3, because the porous bottom surface 25 of inner core 3 will with filtering hole, fluid It is directed through suction channel to siphon away, tissue samples are left in an inner core 3, when one tissue samples aspiration procedure of completion Afterwards, rotatable bottle cap 2, collection hole 6 is made to be directed at another inner core 3, so as to carry out next tissue samples aspiration procedure.It is preferred that Ground, it is independent of each other that can place in bottle 5 between 4 inner cores, 3,4 inner cores 3, and the size and volume of 4 inner cores 3 can roots According to needing to be designed, 4 inner cores 3 can be of the same size with volume or different size and volume, 4 inner cores 3 it Between spacing can be it is consistent can also be different, it is preferable that the cross-sectional area of 4 inner cores 3 is identical, 4 inner cores 3 It is of the same size, the spacing between inner core 3 is consistent.
When inner core 3 is contained in bottle 5, the porous bottom surface 25 and circular filter net 8 of inner core 3 can play double filtration Effect, separated so as to preferably carry out tissue samples with fluid, the porous bottom surface 25 and circular filter net 8 of inner core 3 can bases Need to be designed to different pore sizes, realize different sample separating capacities.For example, the aperture of the porous bottom surface 25 of inner core 3 can Big with the aperture than circular filter net 8, larger tissue samples can be stayed in inner core 3, and less tissue samples are due to ring The presence of shape screen pack 8, the bottom of bottle 5 can be stayed in, so as to which suction channel, under normal circumstances, tissue samples will not be entered It can be stored in inner core 3, less tissue samples can also stay in the bottom of bottle 5;Even if under special circumstances, i.e. tissue samples Do not enter into inner core 3 and be directly entered in bottle 5, at this moment due to the presence of circular filter net 8, can also avoid group in aspiration procedure Knit sample to be siphoned away by mistake, so as to reduce the risk of operation.In addition, the aperture of the porous bottom surface 25 of inner core 3 can also be with annular filter The aperture of net 8 is identical, and under normal circumstances, tissue samples can be stored in inner core 3;Even if under special circumstances, i.e. tissue sample Originally do not enter into inner core 3 and be directly entered in bottle 5, at this moment due to the presence of circular filter net 8, can also avoid in aspiration procedure Tissue samples are siphoned away by mistake, so as to reduce the risk of operation.Because the porous bottom surface 25 of inner core 3 is located at the top of bottle 5, and Circular filter net 8 is arranged on the bottom face center of bottle 5, and the two has larger space spacing, therefore greatly reduces The problem of being blocked between the porous bottom surface 25 of inner core 3 and the filtering hole of circular filter net 8 because distance closely adheres to foul very much.
As illustrated in figures 4-5, correct fixed and positioned in order to ensure inner core 3, the tissue collecting and separator also have The location structure of inner core 3 so that in installation process, inner core 3 can be located at correct region.The location structure of inner core 3 is simple, easily Operation, it can make it that the installation site of each inner core 3 is correct and will not be moved in use.Preferably, this is interior The location structure of core 3 can have one or more groups of corresponding convex 32,34 and recess 31,33, the corresponding convex of one of which 32,34 and recess 31,33 can be located at bottle 5 inner surface and inner core 3 outer arcuate wall 23, another group of corresponding convex 32,34 and recess 31,33 can be located at support column 4 outer surface and inner core 3 inside arcwall 24.Preferably, the inner core 3 is fixed Bit architecture may include recessed on the convex 32 of outer surface and the inside arcwall 24 of corresponding inner core 3 of support column 4 Place 31, the convex 32 of the outer surface of the support column 4 from support column 4 it is bottom up extend to it is concordant with the upper surface of support column 4, and With the horizontal concordant opening position of the step-like protrusion 9 of bottle 5, channel direction from the convex 32 to support column 4 it is slightly concave enter 35, make Obtain the convex 32 extend downwardly from concordant with the upper surface of support column 4 it is L-shaped, during inner core 3 is placed, internal arc The recess 31 of wall 24 and the corresponding cocker of convex 32 positioned at the outer surface of support column 4 and, prevent inner core from rotating, and close The porous bottom surface 25 in the internal direction of arcwall 24 can be placed on recessed 35, the recess 31 on internal arcwall 24 and convex 32 Match.Preferably, the location structure of inner core 3 may include convex 34 and the corresponding inner core 3 of the inner surface positioned at bottle 5 Outer arcuate wall 23 on recess 33, the convex 34 from the step-like protrusion 9 of the inner surface of bottle 5 upwardly extend 2mm-5mm a left side The right side, in any shape that can be set as needed, it is preferable that the convex 34 can be inverted trapezoidal, the outer arcuate wall 23 of inner core 3 Recess 33 can match with convex 34.The inner core 3 is fixed with bottle 5 and support column 4 using concavo-convex manner screens, the inner core 3 The cooperation of ipt card position is combined into bottle 5 and matching somebody with somebody for support column 4, inner core 3 can be achieved and be easily removed, it is simple to operate.
As shown in Figure 6A, bottle cap 2 can include positioning instruction, be used to refer to the relative position of bottle cap 2 and inner core 3, and this is fixed Position instruction can be structural instruction or visual instruction.Preferably, prominent positioning can indicates on the edge of bottle cap 2 10, it can indicate to collect hole 6 and the relative position of inner core 3, protrusion positioning instruction can be that colored triangle indicates.Separately Outside, inner core 3 can also carry the mark of numeral or letter, so as to indicate to collect hole 6 and the relative position of inner core 3.
As shown in Figure 6B, there can be structure positioning instruction under bottle cap 2, can be at least one projection, the projection can be with For fan-shaped raised location structure 11, the raised location structure 11 of the sector is more slightly smaller than the area of the porous bottom surface 25 of inner core 3, guarantees Fall completely within inner core 3, during bottle cap 2 rotates relative to bottle 5, the raised location structure 11 of the sector can be with inner core 3 Effect, slight click is produced so that user has touch feeling, so as to prompt user to be rotated to collection hole 6 and its In the corresponding correct position of an inner core 3.
As shown in figures 1 to 6, the assembling flow path of the tissue collecting and separator:Annular filter with hollow support post 4 Net 8 is arranged on the bottom center of the bottom of bottle 5, between the inner surface on support column 4 and the top of bottle 5, the inner core 3 of ideal quantity It is removably mounted on independently of one another in the step-like protrusion 9 of the upper inside surface of bottle 5, and passes through a series of recessed knot of projection Structure is fixed respectively with bottle 5 and support column 4, and so as to prevent inner core 3 from rotating, bottle cap 2 can be covered on bottle 5, and the bottle cap 2 has One suction tube 7 and a collection hole 6, flexible pipe 1 can be by being connected, so as to which bottle cap 2 be peeped with interior with collecting the progress pipeline of hole 6 Mirror connects to form collection channel, and suction tube 7 can be connected up to the effect of suction with suction system.
In order to collect tissue samples from the patient, user can select to carry out tissue using one of inner core 3 Collect, bottle cap 2, which can rotate, to collect hole 6 positioned at the top of an inner core 3, when being aspirated by suction system, stream After body and tissue samples can enter collection hole 6 by collection channel, fall into inner core 3, subsequent fluid is by the bottom of bottle 5 After circular filter net 8, it is sucked away in the suction channel formed from suction tube.When completing a tissue samples suction, revolving bottle Lid 2 makes collection hole 6 be located at the top of another inner core 3, can proceed with second of suction.
Described above is only the preferred embodiment of the application, is made skilled artisans appreciate that or realizing the application Invention.A variety of modifications and combination for these embodiments will be apparent for those skilled in the art, Generic principles defined herein can be real in other embodiments in the case where not departing from spirit herein or scope It is existing.Therefore, the application will not be limited in the embodiments shown herein, and be to fit to and principles disclosed herein The most wide scope consistent with features of novelty.

Claims (11)

1. a kind of tissue specimen collection and separator, it is characterised in that the tissue specimen collection and separator include:Bottle Body, the bottle have the top of the first volume and the bottom of the second volume;It is suitable for the bottle cap on the top, bottle cap, which has, to be connect Receive the duct of tissue samples;Circular filter net, the bottom center installed in bottle bottom, the circular filter net has can be from bottle The hollow support post that body bottom upwardly extends, between the support column and the inner vessel surface, at least one inner core is removable It is arranged on the bottle top with unloading, the inner core has multiple side walls and a porous bottom surface, the porous bottom surface of the inner core Tissue samples can be filtered, tissue samples is maintained at the top of the volume of bottle first, and fluid flows into the bottle the The bottom of two volumes.
2. tissue specimen collection according to claim 1 and separator, it is characterised in that the inner surface tool of the bottle There is step-like protrusion, the inner core can be placed in the step-like protrusion.
3. tissue specimen collection according to claim 1 or 2 and separator, it is characterised in that the inner core has two Individual recess, respectively the convex screens with the convex of inner vessel surface and the outer surface of support column are fixed.
4. tissue specimen collection according to claim 1 or 2 and separator, it is characterised in that the inner core it is porous Bottom surface and the circular filter net pore size are identical or different.
5. tissue specimen collection according to claim 4 and separator, it is characterised in that the porous bottom surface of the inner core Aperture be more than the circular filter net aperture.
6. tissue specimen collection according to claim 1 or 2 and separator, it is characterised in that the inner core is one Or it is multiple, and independently of one another.
7. tissue specimen collection according to claim 6 and separator, it is characterised in that the inner core is 4, and that This independence.
8. tissue specimen collection according to claim 1 and separator, it is characterised in that the bottle cap has one and taken out Suction pipe, the suction tube can be extended down into bottle from the surface of bottle cap, so as to form a suction channel.
9. tissue specimen collection according to claim 8 and separator, it is characterised in that there is positioning on the bottle cap Instruction.
10. tissue specimen collection according to claim 9 and separator, it is characterised in that have on the bottle cap edge There is prominent positioning instruction.
11. tissue specimen collection according to claim 9 and separator, it is characterised in that have below the bottle cap Fan-shaped raised location structure.
CN201711075864.XA 2017-11-06 2017-11-06 Tissue specimen collection and separator Pending CN107811658A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN201711075864.XA CN107811658A (en) 2017-11-06 2017-11-06 Tissue specimen collection and separator
PCT/CN2018/076420 WO2019085342A1 (en) 2017-11-06 2018-02-12 Tissue sample collection and separation device

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201711075864.XA CN107811658A (en) 2017-11-06 2017-11-06 Tissue specimen collection and separator

Publications (1)

Publication Number Publication Date
CN107811658A true CN107811658A (en) 2018-03-20

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Application Number Title Priority Date Filing Date
CN201711075864.XA Pending CN107811658A (en) 2017-11-06 2017-11-06 Tissue specimen collection and separator

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CN (1) CN107811658A (en)
WO (1) WO2019085342A1 (en)

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Address after: 210000 No. three, No. 10, hi tech Road, Nanjing hi tech Industrial Development Zone, Jiangsu, China

Applicant after: Nanwei Medical Technology Co., Ltd

Address before: 210000 No. three, No. 10, hi tech Road, Nanjing hi tech Industrial Development Zone, Jiangsu, China

Applicant before: Micro-Tech (Nanjing) Co., Ltd.