CN107805390A - A kind of preparation method of high anti-aging antibacterial Medical rubber plug - Google Patents
A kind of preparation method of high anti-aging antibacterial Medical rubber plug Download PDFInfo
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- CN107805390A CN107805390A CN201711161984.1A CN201711161984A CN107805390A CN 107805390 A CN107805390 A CN 107805390A CN 201711161984 A CN201711161984 A CN 201711161984A CN 107805390 A CN107805390 A CN 107805390A
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L23/00—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
- C08L23/26—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers modified by chemical after-treatment
- C08L23/28—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers modified by chemical after-treatment by reaction with halogens or compounds containing halogen
- C08L23/283—Halogenated homo- or copolymers of iso-olefins
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L83/00—Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon only; Compositions of derivatives of such polymers
- C08L83/04—Polysiloxanes
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K2201/00—Specific properties of additives
- C08K2201/011—Nanostructured additives
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
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- C08L2201/08—Stabilised against heat, light or radiation or oxydation
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2312/00—Crosslinking
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Abstract
The invention discloses a kind of preparation method of high anti-aging antibacterial Medical rubber plug, belong to rubber preparing technical field.The present invention obtains vulcanizing mixed rubber using the silicon rubber with certain heat endurance and chlorinated scoline under vulcanization reaction, it is mixed with the anti-aging antibacterial substance such as modified manometer silicon dioxide, modified kaolin and modifying titanium dioxide to obtain high anti-aging antibacterial Medical rubber plug, oxygen molecule is hindered to spread in rubber, the heatproof air aging performance for being advantageous to Medical rubber plug is improved, the kaolin with heat-resisting quantity is modified by aluminium chloride and sodium chloride again, improves the anti-aging of Medical rubber plug；Using the nano titanium oxide with heat endurance through overactivation and acidolysis, can direct attack bacteria cell, cause the organic matter degradation in bacterial cell, hinder the materials such as ozone to the further decomposition of rubber, the anti-aging of Medical rubber plug is further improved, is with a wide range of applications.
Description
Technical field
The invention discloses a kind of preparation method of high anti-aging antibacterial Medical rubber plug, belong to rubber technology of preparing
Field.
Background technology
Natural rubber is that the latex flowed out when being tapped rubber by para ruber is made through solidifying, after drying.1770, Britain
Chemist J. Priestleys have found that rubber can be used to wipe pencil writing, and the material of this purposes was referred to as into rubber at that time,
This word is used till today always.The strand of rubber can be crosslinked, and when the rubber after crosslinking is deformed by external force effect, be had fast
The ability of original is replied immediately, and there is good physical and mechanical property and chemical stability.Rubber is the base stock of rubber industry, extensively
It is general to be used to manufacture tire, sebific duct, adhesive tape, cable and other various rubbers.
Current rubber plug is widely used in blocking medical or medicinal opening portion, because rubber high resilience, energy
Produce remarkable sealing, shroud of gas, resistance to acupuncture etc. to the content of container, but because natural rubber is in rubber tapping and processed
Its complicated inevitably is caused by the pollution of bacterium, plant leaf, pollen etc. in journey, it is miscellaneous to there is foreign preteins etc.
Matter causes injection thermal source, clarity and particulate matter etc., the problem of leaving hidden trouble to drug safety, and China is in 1995
The deployment that Ordinary natural rubber stoppers packaging medicine is phased out by the time limit is made year.Therefore, national correlation department from " eight or five " when
The support policy such as phase, research and development, technological transformation by encouraging, supporting substitute products, promote medicine to eliminate and use common day
Right plug packing work, State Food and Drug Administration have first eliminated kitasamycin etc. 13 from 1 day July in 2001
Kind of antibiotic powder injection is packed using Ordinary natural rubber stoppers, and biological products, blood product, cold have been eliminated in 1 day January in 2002
Dry injection antibiotic powder injection is freezed to pack using Ordinary natural rubber stoppers.
Rubber industry was quickly grown in recent years, and rubber is also more and more extensive therefore right in the development of field of medical materials
The requirement of rubber performance is also higher, and it will not only have certain toughness and corrosion resistance, also there is excellent solvent resistance
And anti-microbial property, nontoxic performance also require too high.And the rubber of currently the majority all exist be easy to thermo-oxidative ageing and
The defects of fungistatic effect is bad, therefore, a kind of Medical rubber plug for being not easy to deterioration by oxidation and good antimicrobial effect is invented to rubber
Product preparing technical field has positive effect.
The content of the invention
The technical problems to be solved by the invention：For current common Medical rubber plug in use, it is easy to hot oxygen
A kind of the defects of aging and bad fungistatic effect, there is provided preparation method of high anti-aging antibacterial Medical rubber plug.
In order to solve the above technical problems, the present invention is using technical scheme as described below：
A kind of preparation method of high anti-aging antibacterial Medical rubber plug, it is characterised in that specifically preparation process is：
（1）100 mesh sieves are crossed after weighing the grinding of 20~30g nano silicons, collect sieving powder, then by sodium pyrophosphate, 12
Sodium alkyl sulfate and ethoxylated dodecyl alcohol are mixed, and obtain making dispersant by oneself, and sieving powder and self-control dispersant are mixed
Conjunction is placed in ultrasonic disperse machine and is stirred by ultrasonic, ultrasonic disperse terminate it is rear still aging, then by the product after ageing carry out centrifugation point
From it is modified manometer silicon dioxide to obtain sediment；
（2）Weigh after 100~200g kaolin, 20~30g aluminium chloride and 16~20g sodium chloride mixed grinding crush and cross 100 mesh
Sieve, sieving mixed-powder is collected, sieving mixed-powder is poured into kiln and calcined, obtains modified kaolin；
（3）Weigh 60~80g nano titanium oxides and pour into kiln and activate, obtain activating nano titanium oxide, with salt acid elution
Activate nano titanium oxide 3~5 times, porous nano titanium dioxide is obtained, by porous nano titanium dioxide and titanate coupling agent
201 mix, and obtain modified porous nano titanium oxide；
（4）Melt, vulcanized by waiting mass ratio to mix to be placed in stir in Muffle furnace by silicon rubber, chlorinated scoline and Sulfur
Mixed rubber, count in parts by weight, weigh 30~40 parts of vulcanization mixed rubbers, 12~16 parts of modified manometer silicon dioxides, 8 respectively
~10 parts of modified kaolins and 6~8 parts of modified porous nano titanium oxide mixing are placed in Muffle furnace and stir fusing, then add 5
~7 parts of calcium carbonate, 4~6 parts of zinc oxide, 3~5 parts of ATBCs and 2~4 parts of carbon blacks, continue insulation mixing and stir
Mix, obtain vulcanizing rubber latex, vulcanization rubber latex is poured into rubber stopper mould, is placed in baking oven and dries, after demoulding, is obtained
Medical rubber plug base substrate, with deionized water rinsing and leaching Medical rubber plug base substrate, natural air drying, you can high anti-aging suppression is made
Bacterium Medical rubber plug.
Step（1）Described milling time is 5~7min, sodium pyrophosphate, lauryl sodium sulfate and laruyl alcohol polyoxy second
The mass ratio of alkene ether is 1：4：5, mixing time is 6~8min, makes dispersant by oneself, by the quality of powder and self-control dispersant of sieving
Than for 3：1, the ultrasonic agitation time is 45~60min, and the still aging time is 1~2 day.
Step（2）The described time that grinds is 10~12min, and calcining heat is 800~1000 DEG C, and calcination time is
1~2h.
Step（3）Described activation temperature is 200~240 DEG C, and soak time is 16~20min, the mass fraction of hydrochloric acid
For 20%, the mass ratio of porous nano titanium dioxide and titanate coupling agent 201 is 1：2, mixing time is 10~12min.
Step（4）Described stirring fusion temperature is 100~120 DEG C, and stirring fusing time is 35~45min, fusing temperature
Spend for 850~950 DEG C, fusing time is 20~30min, and continuation mixing time is 1~3h, and rubber stopper die size is upper diameter
For 23mm, under a diameter of 17mm, be highly 26mm, drying temperature is 90~110 DEG C, and drying time is 1~2h, and washing time is
16~20min.
Compared with other method, advantageous effects are the present invention：
（1）The present invention obtains vulcanization using the silicon rubber with certain heat endurance and chlorinated scoline under vulcanization reaction and mixed
Rubber is closed, it is mixed into system with the anti-aging antibacterial substance such as modified manometer silicon dioxide, modified kaolin and modifying titanium dioxide
It is standby to obtain high anti-aging antibacterial Medical rubber plug, nano silicon is modified by dispersant first, due to dispersant
Processing makes nano silicon uniform adsorption on rubber particles surface, after latex coagulation, dispersant and the suction of rubber particles surface
Attached protein plays the effect of bulking agent jointly, improves the interface of polar nano silica and non-polar rubber hydrocarbon, carries
The dispersiveness of high nano silicon and physical crosslinking effect, form network structure, hinder oxygen molecule and expand in rubber
Dissipating, the oxygen and degraded of rubber molecular chain are shielded, the heatproof air aging performance for being advantageous to Medical rubber plug is improved,
The kaolin with heat-resisting quantity is modified by aluminium chloride and sodium chloride again, makes heavy metal element and some harmful elements
Vapored away at calcination temperatures in the form of chloride, effectively reduce the harm using Medical rubber plug, formed effective anti-
Aging protective layer, improve the ageing resistace of Medical rubber plug；
（2）The present invention utilizes the nano titanium oxide with heat endurance through overactivation and acidolysis, by itself and titanate coupling agent
Mix, form tough and tensile porous nano titanium dioxide, it is cloudy that chemical activity very strong superoxides is generated when by illumination
Ion radical and hydroxyl free radical, can direct attack bacteria cell, cause the organic matter degradation in bacterial cell, with this
Bacterium is killed, and is allowed to decompose, improves the anti-aging and biocidal property of Medical rubber plug again, continues to add age resistor, plasticizer
And antioxidant, the surface of rubber stopper is dispersed in, effective anti-aging protective layer is formd, hinders the materials pair such as ozone
Rubber further decomposes, and further improves the ageing resistace of Medical rubber plug, is with a wide range of applications.
Embodiment
Weigh after 20~30g nano silicons grind 5~7min and cross 100 mesh sieves, collect sieving powder, then in mass ratio
For 1：4：Sodium pyrophosphate, lauryl sodium sulfate and ethoxylated dodecyl alcohol are mixed 6~8min by 5, obtain self-control point
Powder, it is 3 in mass ratio by sieving powder and self-control dispersant：1 mixing be placed in ultrasonic disperse machine ultrasonic agitation 45~
60min, ultrasonic disperse terminates latter still aging 1~2 day, then the product after ageing is centrifuged, and obtains sediment i.e.
For modified manometer silicon dioxide；Weigh 100~200g kaolin, 20~30g aluminium chloride and 16~20g sodium chloride mixed grinding powder
100 mesh sieves are crossed after broken 10~12min, collect sieving mixed-powder, sieving mixed-powder is poured into 800~1000 DEG C of kiln
1~2h is calcined, obtains modified kaolin；Weigh 60~80g nano titanium oxides to pour into kiln, activated at 200~240 DEG C
16~20min, obtain activating nano titanium oxide, nano titanium oxide 3~5 is activated with the salt acid elution that mass fraction is 20%
It is secondary, porous nano titanium dioxide is obtained, is 1 in mass ratio by porous nano titanium dioxide and titanate coupling agent 201：2 mixing
10~12min is stirred, obtains modified porous nano titanium oxide；By waiting mass ratio by silicon rubber, chlorinated scoline and Sulfur
Mixing is placed in Muffle furnace, and stirring 35~45min of fusing, obtains vulcanizing mixed rubber, by weight at being 100~120 DEG C in temperature
Number meter is measured, weighs 30~40 parts of vulcanization mixed rubbers, 12~16 parts of modified manometer silicon dioxides, 8~10 parts of modified height respectively
Ridge soil and 6~8 parts of modified porous nano titanium oxides mixing be placed in stirring fusing 20 in 850~950 DEG C of Muffle furnace~
30min, then 5~7 parts of calcium carbonate, 4~6 parts of zinc oxide, 3~5 parts of ATBCs and 2~4 parts of carbon blacks are added, after
Continuation of insurance temperature mix 1~3h, obtain vulcanize rubber latex, will vulcanization rubber latex pour into upper a diameter of 23mm, under it is a diameter of
17mm, highly in 26mm rubber stopper mould, to be placed in 90~110 DEG C of baking oven and drying 1~2h, after demoulding, obtain medical
Rubber stopper base substrate, with deionized water rinsing and leaching Medical rubber plug 16~20min of base substrate, natural air drying, you can be made high anti-
The antibacterial Medical rubber plug of aging.
Example 1
100 mesh sieves are crossed after weighing 20g nano silicons grinding 5min, collect sieving powder, then are 1 in mass ratio：4：5 by Jiao
Sodium phosphate, lauryl sodium sulfate and ethoxylated dodecyl alcohol mix 6min, obtain making dispersant by oneself, by the powder that sieves
It is 3 in mass ratio with self-control dispersant：1 mixing, which is placed in ultrasonic disperse machine, is stirred by ultrasonic 45min, and ultrasonic disperse is stood after terminating
Ageing 1 day, then the product after ageing is centrifuged, it is modified manometer silicon dioxide to obtain sediment；Weigh 100g
Kaolin, 20g aluminium chloride and 16g sodium chloride mixed grinding cross 100 mesh sieves after crushing 10min, collect sieving mixed-powder, incited somebody to action
Sieve mixed-powder, which is poured into 800 DEG C of kiln, calcines 1h, obtains modified kaolin；Weigh 60g nano titanium oxides and pour into kiln
In, 16min is activated at 200 DEG C, obtains activating nano titanium oxide, nanometer is activated with the salt acid elution that mass fraction is 20%
Titanium dioxide 3 times, obtains porous nano titanium dioxide, by porous nano titanium dioxide and titanate coupling agent 201 in mass ratio
For 1：2 mix 10min, obtain modified porous nano titanium oxide；By wait mass ratio by silicon rubber, chlorinated scoline and
Sulfur mixing is placed in Muffle furnace, and stirring fusing 35min, obtains vulcanizing mixed rubber, in parts by weight at being 100 DEG C in temperature
Meter, 30 parts of vulcanization mixed rubbers is weighed respectively, 12 parts of modified manometer silicon dioxides, 8 parts of modified kaolins and 6 parts modified porous are received
Rice titanium dioxide mixing is placed in 850 DEG C of Muffle furnace stirring fusing 20min, then add 5 parts of calcium carbonate, 4 parts of zinc oxide, 3 parts
ATBC and 2 parts of carbon blacks, continue insulation and mix 1h, obtain vulcanizing rubber latex, latex rubber will be vulcanized
Liquid pour into a diameter of 23mm, under a diameter of 17mm, highly for 26mm rubber stopper mould in, be placed in 90 DEG C of baking oven dry
1h, after demoulding, Medical rubber plug base substrate is obtained, with deionized water rinsing and leaching Medical rubber plug base substrate 16min, natural wind
It is dry, you can high anti-aging antibacterial Medical rubber plug is made.
Example 2
100 mesh sieves are crossed after weighing 25g nano silicons grinding 6min, collect sieving powder, then are 1 in mass ratio：4：5 by Jiao
Sodium phosphate, lauryl sodium sulfate and ethoxylated dodecyl alcohol mix 7min, obtain making dispersant by oneself, by the powder that sieves
It is 3 in mass ratio with self-control dispersant：1 mixing, which is placed in ultrasonic disperse machine, is stirred by ultrasonic 50min, and ultrasonic disperse is stood after terminating
Ageing 1 day, then the product after ageing is centrifuged, it is modified manometer silicon dioxide to obtain sediment；Weigh 150g
Kaolin, 25g aluminium chloride and 18g sodium chloride mixed grinding cross 100 mesh sieves after crushing 11min, collect sieving mixed-powder, incited somebody to action
Sieve mixed-powder, which is poured into 900 DEG C of kiln, calcines 1.5h, obtains modified kaolin；Weigh 70g nano titanium oxides and pour into kiln
In stove, 18min is activated at 220 DEG C, obtains activating nano titanium oxide, is received with the salt acid elution activation that mass fraction is 20%
Rice titanium dioxide 4 times, obtains porous nano titanium dioxide, porous nano titanium dioxide and titanate coupling agent 201 is pressed into quality
Than for 1：2 mix 11min, obtain modified porous nano titanium oxide；By waiting mass ratio by silicon rubber, chlorinated scoline
It is placed in Sulfur mixing in Muffle furnace, stirring fusing 40min, obtains vulcanizing mixed rubber, by weight at being 110 DEG C in temperature
Number meter, it is modified porous that 35 parts of vulcanization mixed rubbers, 14 parts of modified manometer silicon dioxides, 9 parts of modified kaolins and 7 parts are weighed respectively
Nano titanium oxide mixing is placed in stirring fusing 25min in 900 DEG C of Muffle furnace, then adds 6 parts of calcium carbonate, 5 parts of zinc oxide, 4
Part ATBC and 3 parts of carbon blacks, continue insulation and mix 2h, obtain vulcanizing rubber latex, rubber will be vulcanized
Emulsion pour into a diameter of 23mm, under a diameter of 17mm, highly for 26mm rubber stopper mould in, be placed in 95 DEG C of baking oven do
Dry 1.5h, after demoulding, Medical rubber plug base substrate is obtained, it is natural with deionized water rinsing and leaching Medical rubber plug base substrate 18min
Air-dry, you can high anti-aging antibacterial Medical rubber plug is made.
Example 3
100 mesh sieves are crossed after weighing 30g nano silicons grinding 7min, collect sieving powder, then are 1 in mass ratio：4：5 by Jiao
Sodium phosphate, lauryl sodium sulfate and ethoxylated dodecyl alcohol mix 8min, obtain making dispersant by oneself, by the powder that sieves
It is 3 in mass ratio with self-control dispersant：1 mixing, which is placed in ultrasonic disperse machine, is stirred by ultrasonic 60min, and ultrasonic disperse is stood after terminating
Ageing 2 days, then the product after ageing is centrifuged, it is modified manometer silicon dioxide to obtain sediment；Weigh 200g
Kaolin, 30g aluminium chloride and 20g sodium chloride mixed grinding cross 100 mesh sieves after crushing 12min, collect sieving mixed-powder, incited somebody to action
Sieve mixed-powder, which is poured into 1000 DEG C of kiln, calcines 2h, obtains modified kaolin；Weigh 80g nano titanium oxides and pour into kiln
In, 20min is activated at 240 DEG C, obtains activating nano titanium oxide, nanometer is activated with the salt acid elution that mass fraction is 20%
Titanium dioxide 5 times, obtains porous nano titanium dioxide, by porous nano titanium dioxide and titanate coupling agent 201 in mass ratio
For 1：2 mix 12min, obtain modified porous nano titanium oxide；By wait mass ratio by silicon rubber, chlorinated scoline and
Sulfur mixing is placed in Muffle furnace, and stirring fusing 45min, obtains vulcanizing mixed rubber, in parts by weight at being 120 DEG C in temperature
Meter, it is modified porous that 40 parts of vulcanization mixed rubbers, 16 parts of modified manometer silicon dioxides, 10 parts of modified kaolins and 8 parts are weighed respectively
Nano titanium oxide mixing is placed in stirring fusing 30min in 950 DEG C of Muffle furnace, then adds 7 parts of calcium carbonate, 6 parts of zinc oxide, 5
Part ATBC and 4 parts of carbon blacks, continue insulation and mix 3h, obtain vulcanizing rubber latex, rubber will be vulcanized
Emulsion pour into a diameter of 23mm, under a diameter of 17mm, highly for 26mm rubber stopper mould in, be placed in 110 DEG C of baking oven
2h is dried, after demoulding, obtains Medical rubber plug base substrate, it is natural with deionized water rinsing and leaching Medical rubber plug base substrate 20min
Air-dry, you can high anti-aging antibacterial Medical rubber plug is made.
Comparative example
With the high anti-aging antibacterial Medical rubber plug of Jiangsu company as a comparison case
High anti-aging antibacterial medical grade rubber in the anti-aging antibacterial Medical rubber plug of height produced by the present invention and comparative example is filled in
Row performance detection, shown under testing result：
1st, method of testing：
The average bacterium number test of Escherichia coli carries out bacteriostasis property detection by JC/T897-2002 regulation；
The average bacterium number test of staphylococcus aureus carries out bacteriostasis property detection by JC/T897-2002 regulation；
By the rubber stopper in example 1~3 and comparative example under 500Lx intensity of illumination illumination 10 days, then measure each rubber respectively
Tensile strength, elongation at break, the color change of plug.
Table 1.
It can be seen from data in table 1, the anti-aging antibacterial Medical rubber plug bacteriostasis rate of height produced by the present invention is good, ageing resistace
It is good, have broad application prospects.
Claims (5)
1. a kind of preparation method of high anti-aging antibacterial Medical rubber plug, it is characterised in that specifically preparation process is：
（1）100 mesh sieves are crossed after weighing the grinding of 20~30g nano silicons, collect sieving powder, then by sodium pyrophosphate, 12
Sodium alkyl sulfate and ethoxylated dodecyl alcohol are mixed, and obtain making dispersant by oneself, and sieving powder and self-control dispersant are mixed
Conjunction is placed in ultrasonic disperse machine and is stirred by ultrasonic, ultrasonic disperse terminate it is rear still aging, then by the product after ageing carry out centrifugation point
From it is modified manometer silicon dioxide to obtain sediment；
（2）Weigh after 100~200g kaolin, 20~30g aluminium chloride and 16~20g sodium chloride mixed grinding crush and cross 100 mesh
Sieve, sieving mixed-powder is collected, sieving mixed-powder is poured into kiln and calcined, obtains modified kaolin；
（3）Weigh 60~80g nano titanium oxides and pour into kiln and activate, obtain activating nano titanium oxide, with salt acid elution
Activate nano titanium oxide 3~5 times, porous nano titanium dioxide is obtained, by porous nano titanium dioxide and titanate coupling agent
201 mix, and obtain modified porous nano titanium oxide；
（4）Melt, vulcanized by waiting mass ratio to mix to be placed in stir in Muffle furnace by silicon rubber, chlorinated scoline and Sulfur
Mixed rubber, count in parts by weight, weigh 30~40 parts of vulcanization mixed rubbers, 12~16 parts of modified manometer silicon dioxides, 8 respectively
~10 parts of modified kaolins and 6~8 parts of modified porous nano titanium oxide mixing are placed in Muffle furnace and stir fusing, then add 5
~7 parts of calcium carbonate, 4~6 parts of zinc oxide, 3~5 parts of ATBCs and 2~4 parts of carbon blacks, continue insulation mixing and stir
Mix, obtain vulcanizing rubber latex, vulcanization rubber latex is poured into rubber stopper mould, is placed in baking oven and dries, after demoulding, is obtained
Medical rubber plug base substrate, with deionized water rinsing and leaching Medical rubber plug base substrate, natural air drying, you can high anti-aging suppression is made
Bacterium Medical rubber plug.
A kind of 2. preparation method of high anti-aging antibacterial Medical rubber plug according to claim 1, it is characterised in that：Step
（1）Described milling time is 5~7min, the mass ratio of sodium pyrophosphate, lauryl sodium sulfate and ethoxylated dodecyl alcohol
For 1：4：5, mixing time is 6~8min, makes dispersant by oneself, and the mass ratio by sieve powder and self-control dispersant is 3：1, ultrasound
Mixing time is 45~60min, and the still aging time is 1~2 day.
A kind of 3. preparation method of high anti-aging antibacterial Medical rubber plug according to claim 1, it is characterised in that：Step
（2）The described time that grinds is 10~12min, and calcining heat is 800~1000 DEG C, and calcination time is 1~2h.
A kind of 4. preparation method of high anti-aging antibacterial Medical rubber plug according to claim 1, it is characterised in that：Step
（3）Described activation temperature is 200~240 DEG C, and soak time is 16~20min, and the mass fraction of hydrochloric acid is 20%, porous to receive
The mass ratio of rice titanium dioxide and titanate coupling agent 201 is 1：2, mixing time is 10~12min.
A kind of 5. preparation method of high anti-aging antibacterial Medical rubber plug according to claim 1, it is characterised in that：Step
（4）Described stirring fusion temperature is 100~120 DEG C, and stirring fusing time is 35~45min, and fusion temperature is 850~950
DEG C, fusing time is 20~30min, and continuation mixing time is 1~3h, and rubber stopper die size is upper a diameter of 23mm, lower straight
Footpath is 17mm, is highly 26mm, and drying temperature is 90~110 DEG C, and drying time is 1~2h, and washing time is 16~20min.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711161984.1A CN107805390A (en) | 2017-11-21 | 2017-11-21 | A kind of preparation method of high anti-aging antibacterial Medical rubber plug |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711161984.1A CN107805390A (en) | 2017-11-21 | 2017-11-21 | A kind of preparation method of high anti-aging antibacterial Medical rubber plug |
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| CN107805390A true CN107805390A (en) | 2018-03-16 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113698640A (en) * | 2021-09-15 | 2021-11-26 | 湖南科技学院 | Preparation method of nano calcium carbonate/bio-based film |
| CN113755014A (en) * | 2021-05-26 | 2021-12-07 | 安阳崇高纳米材料科技有限公司 | Antibacterial modified rubber composition and preparation method thereof |
-
2017
- 2017-11-21 CN CN201711161984.1A patent/CN107805390A/en not_active Withdrawn
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113755014A (en) * | 2021-05-26 | 2021-12-07 | 安阳崇高纳米材料科技有限公司 | Antibacterial modified rubber composition and preparation method thereof |
| CN113698640A (en) * | 2021-09-15 | 2021-11-26 | 湖南科技学院 | Preparation method of nano calcium carbonate/bio-based film |
| CN113698640B (en) * | 2021-09-15 | 2023-06-20 | 湖南科技学院 | Preparation method of nano calcium carbonate/bio-based film |
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