CN107802785A - A kind of capsule medicine and preparation method for being used to treat breast cancer - Google Patents

A kind of capsule medicine and preparation method for being used to treat breast cancer Download PDF

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CN107802785A
CN107802785A CN201711109328.7A CN201711109328A CN107802785A CN 107802785 A CN107802785 A CN 107802785A CN 201711109328 A CN201711109328 A CN 201711109328A CN 107802785 A CN107802785 A CN 107802785A
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chinese
medicine
breast cancer
leaf
mass parts
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孙思远
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Sichuan Yichuang Biotechnology Co Ltd
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Sichuan Yichuang Biotechnology Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/13Coniferophyta (gymnosperms)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/233Bupleurum
    • AHUMAN NECESSITIES
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    • A61K36/18Magnoliophyta (angiosperms)
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    • A61K36/24Apocynaceae (Dogbane family), e.g. plumeria or periwinkle
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/288Taraxacum (dandelion)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/29Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
    • A61K36/296Epimedium
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/54Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/888Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/888Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • A61K36/8884Arisaema, e.g. Jack in the pulpit
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • AHUMAN NECESSITIES
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    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/906Zingiberaceae (Ginger family)
    • A61K36/9066Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
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    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
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    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps

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Abstract

The invention belongs to field of traditional Chinese, it is therefore an objective to a kind of capsule medicine for being used to treat breast cancer be provided according to the understanding mechanism of Chinese traditional treatment breast cancer, each component and its mass parts ratio of the medicine are as follows:90~180g of dandelion, 90~160g of Chinese yew, 150~220g of cepehalotaxus fortunei, 50~100g of SHENLIUGU, 50~120g of alstonia-leaf, 30~90g of Paris polyphylla, 250~500g of Chinese actinidia root, 30~120g of radix bupleuri, fiery 30~100g of leaf, 30~90g of thizoma curculiginis, 30~120g of curcuma zedoary, 15~60g of Chinese cassia tree;Medicine provided by the invention is a good Chinese prescription.

Description

A kind of capsule medicine and preparation method for being used to treat breast cancer
Technical field
The invention belongs to field of traditional Chinese, and in particular to a kind of capsule medicine for being used to treat breast cancer, particularly The capsule medicine used for patient with breast cancer and the field of preparation method.
Background technology
Shown according to relevant document:Female mammary gland is made up of skin, fibr tissue, corpus mamma and fat, breast cancer It is that the malignant tumour in mammary gland galandular epithelium tissue occurs.99% occurs only to account for 1% in women, male in breast cancer.
Mammary gland is not the vitals for maintaining human life activity, and breast cancer in situ is not fatal;But due to breast cancer The cell loss characteristic of normal cell, connects between cell loose, easily comes off.Cancer cell once comes off, and free cancer is thin Born of the same parents can send out whole body with blood or lymph, form transfer, threat to life.Breast cancer turns at present threatens women body and mind to be good for The kinds of tumor of health.
Global breast cancer incidence is in rising trend always since the late 1970s.8, U.S. women is in life 1 people is just had to suffer from breast cancer.China is not the country occurred frequently of breast cancer, but unsuitable optimistic, in recent years China's breast cancer incidence Growth rate is but higher by national 1~2 percentage point occurred frequently.According to National Cancer Center and prevention and control of diseases office of the Ministry of Public Health 2012 The pathogenesis of breast carcinoma data in 2009 announced are shown:National tumour registration area breast cancer incidence occupies female malignant 1st, female mammary gland cancer morbidity(It is rough and careless)The whole nation adds up to 42.55/10 ten thousand, and city is 51.91/10 ten thousand, and rural area is 23.12/10 ten thousand.
So, just how to find a kind of Chinese medicine composition that can effectively treat breast cancer, be those skilled in the art urgently Solve the problems, such as.
The content of the invention
With the continuous development of China's traditional Chinese medicine, in treatment breast cancer, people gradually appreciate Chinese traditional treatment The advantages of breast cancer, and good effect, the advantage such as quick, toxic side effect is small over the course for the treatment of, for existing western medical treatment breast The present situation of gland cancer, the purpose of the present invention is to be to provide a kind of capsule medicine for being used to treat breast cancer, to solve breast cancer The problem of patient gets well and extends life cycle early.The medicine is using common Chinese medicine as raw material, by selecting reasonably Medicine and mass parts ratio, can effectively treat above-mentioned breast cancer.
To reach the purpose of foregoing invention, the technical solution adopted in the present invention is:There is provided a kind of for treating breast cancer Capsule medicine and preparation method, it is characterised in that each component and mass parts of the medicine are than as follows:
90~180g of dandelion, 90~160g of Chinese yew, 150~220g of cepehalotaxus fortunei, 50~100g of SHENLIUGU, alstonia-leaf 50~ 120g, 30~90g of Paris polyphylla, 250~500g of Chinese actinidia root, 30~120g of radix bupleuri, fiery 30~100g of leaf, 30~90g of thizoma curculiginis, curcuma zedoary 30~120g, 15~60g of Chinese cassia tree, auxiliary material:Appropriate starch.
A kind of capsule medicine and preparation method for being used to treat breast cancer, it is characterised in that each group of the medicine Divide and mass parts are than as follows:
100~160g of dandelion, 100~140g of Chinese yew, 160~200g of cepehalotaxus fortunei, 58~90g of SHENLIUGU, alstonia-leaf 58~ 105g, 38~80g of Paris polyphylla, 280~420g of Chinese actinidia root, 38~105g of radix bupleuri, fiery 38~90g of leaf, 38~80g of thizoma curculiginis, curcuma zedoary 38 ~105g, 20~52g of Chinese cassia tree, auxiliary material:Appropriate starch.
A kind of capsule medicine and preparation method for being used to treat breast cancer, it is characterised in that each group of the medicine Divide and mass parts are than as follows:
Dandelion 140g, Chinese yew 120g, cepehalotaxus fortunei 170g, SHENLIUGU 80g, alstonia-leaf 95g, Paris polyphylla 70g, Chinese actinidia root 360g, Radix bupleuri 95g, fiery leaf 80g, thizoma curculiginis 70g, curcuma zedoary 95g, Chinese cassia tree 45g, auxiliary material:Appropriate starch.
A kind of capsule medicine and preparation method for being used to treat breast cancer, it is characterised in that methods described includes as follows Step is prepared:
A, after above-mentioned raw materials Chinese medicine being picked into impurity and dust, it is respectively crushed into coarse according to mass parts ratio and decocts a drug wrapped;
B, the raw material Chinese medicine wrapped is put into after soaking 45min in cold boiling water, then soaked medicine is put into marmite and decocted Three times:1. amount of water is 9~10 times of medicinal material total amount, high heat decoction is first carried out, when 15min is arrived in decoction, turns slow fire and boils 110 Min, leaching decoction;2. amount of water is 8~9 times of dry dregs of a decoction total amount, high heat decoction is first carried out, when 10min is arrived in decoction, is turned Slow fire boils 100 min, leaching decoction;3. amount of water is 7~8 times of dry dregs of a decoction total amount, high heat decoction is first carried out, waits to decoct During to 8min, turn slow fire and boil 90 min, leaching decoction;4. merging decoction three times, and it is concentrated under reduced pressure into every milliliter contained 3g Standard after, that is, obtain drug extract.
C, by the extract dry prepared in above-mentioned " B ", sterilization, and it is standby according to mass parts ratio to be ground into superfine end;
D, the method for preparing Chinese medicine capsules according to traditional common process and auxiliary material, by superfine myrrh thing ground in " C " After sieving, and auxiliary material is put into medicine device and is well mixed in the lump, is then prepared into capsule(Total length after its capsule is sealed is 23.3mm, medicinal powder capacity 0.4~0.5g/ grains), then polish, sealed packaging.
It is a kind of to be used to treat the capsule medicine and preparation method of breast cancer, it is characterised in that the instructions of taking is:Will The capsule medicine prepared is three times a day to take, and once a dose in the morning, afternoon and evening, dosage 3g(6)/ time, warm water delivery service. 30 days are a course for the treatment of, after 3~6 courses for the treatment of of taking medicine, remission:Tumor disappearance, disease accuse recovery from illness.Follow-up more than 1 year, not again See recurrence.
Each raw material Chinese medicine in prescription of the present invention has detailed note in Chinese Pharmacopoeia, Chinese dictionary and China's book on Chinese herbal medicine Carry.The present invention is raw material from most common of which Chinese medicine, gives full play to the pharmacological effect of each component:
Dandelion, nature and flavor:It is bitter, sweet, cold, there is the effect of clearing heat and detoxicating, dispersing swelling and dissipating binds, inducing diuresis for treating strangurtia, swollen for treating furunculosis Poison, acute mastitis, scrofula, hot eyes, pharyngalgia, lung carbuncle, acute appendicitis, jaundice with damp-heat pathogen, puckery pain of heat gonorrhea;
Chinese yew, nature and flavor:It is light, mild-natured, there is the effect of inducing diuresis to remove edema, for treating ephritis edema, difficult urination, diabetes Deng disease;
Cepehalotaxus fortunei, nature and flavor:Seed:It is sweet, puckery, it is mild-natured, there is the effect of disperse accumulations expelling parasite, moisten the lung and relieve the cough, for treating dyspepsia abdomen The diseases such as swollen, infantile malnutrition, malnutrition due to parasitic infestation, xeropulmonary cough;Branch, leaf:It is bitter, puckery, cold in nature, there is the effect of anticancer, for malignant lymphatic The diseases such as knurl, leukaemia, lung cancer, stomach cancer, the cancer of the esophagus, the carcinoma of the rectum;Root:It is bitter, puckery, mild-natured, there is anticancer, the work(of promoting blood circulation and stopping pain Effect, for diseases such as the carcinoma of the rectum, traumatic injuries;
SHENLIUGU, nature and flavor:It is pungent, warm, it is poisonous, there is the effect of resolving sputum scattered plot, blood stasis, cough, stagnate, malaria for treating phlegm The diseases such as disease, Amenorrhea, traumatic injury, carbuncle swells, furunculosis, erysipelas;
Alstonia-leaf, nature and flavor:It is bitter, light, cold in nature, there is the effect of clearing heat and detoxicating, expelling phlegm and arresting coughing, hemostasia and detumescence, feel for treating Emit heating, lung heat cough and asthma, pertussis, icteric hepatitis, stomachache vomiting and diarrhoea, malaria, sore carbuncle swells, treating swelling and pain by traumatic injury, traumatism and bleeding etc. Disease;
Paris polyphylla, nature and flavor:Hardship, it is slightly cold, it is slightly poisonous, there is the effect of clearing heat and detoxicating, swelling and pain relieving, cool liver arresting convulsion, for treating malignant boil The diseases such as sore carbuncle is swollen, abscess of throat, snake bite and insect sting, the pain of injury caused by falling and tumbling, convulsion;
Chinese actinidia root, nature and flavor:It is sour, puckery, cool, there is the effect of clearing heat and detoxicating, dispelling wind and eliminating dampness, diuresis hemostasis, for treating rheumatic bone Bitterly and the disease such as jaundice;
Radix bupleuri, nature and flavor:Bitter, pungent, cold nature, there is inducing diaphoresis to bring down a fever, soothing liver-qi stagnation, rise the effect of lifting yang-energy, it is outer for treating Feel heating, fevers and chills alternate, malaria, liver-depressed hypochondrium pain mammary swelling, have a headache a dizzy, irregular menstruation, the prolapse of the anus of collapse from qi deficiency, the prolapse of uterus, The diseases such as gastroptosis;
Fiery leaf, nature and flavor:It is acrid flavour, sweet, warm-natured, there is the effect of tonifying kidney and strengthening yang, dispelling wind and eliminating dampness, strengthening tendons key bone, for treating impotence Seminal emission, empty cold infertility, frequent micturition mistake Chu, dyspnea and cough due to deficiency of the kidney, soreness and weakness of waist and knees, arthralgia pain due to rheumatism, hemiplegia, four limbs are meciless;
Thizoma curculiginis, nature and flavor:It is pungent, warm, it is slightly poisonous, there is the effect of kidney-replenishing, strengthening the bones and muscles, wet cold dispelling, for treating impotence cold sperm, waist The diseases such as knee crymodynia, rheumathritis, chronic nephritis, seminal emission, aconuresis, trusted subordinate's cold air;
Curcuma zedoary, nature and flavor:It is acrid flavour, hardship, warm-natured, there is the effect of promoting the circulation of qi blood-breaking, Xiao Ji Zhi Tong, vim and vigour are pained, diet for treating The diseases such as stagnant, abdominal distention, amenorrhea due to stagnation of blood, dysmenorrhoea, abdominal mass knurl lump in the abdomen, traumatic injury;
Chinese cassia tree, nature and flavor:It is extremely hot in nature, acrid flavour, sweet, have mends fire supporing yang, let the fire back to its origin, eliminating cold to stop pain, invigorate blood circulation, warming spleen and stomach, The effect of removing internal cold, promoting blood circulation, for treating the Yang-function insufficiency of kidneyzang, cold weak pulse of limb, yang depletion collapse, stomachache diarrhea, cold hernia run quickly globefish, waist and knee Crymodynia, Amenorrhea abdominal mass, cloudy subcutaneous ulcer, streamer and empty sun is floating more, heat in the upper and cold in the lower, impotence, Gong Leng, trusted subordinate's crymodynia, cold of insufficiency type vomiting and diarrhea, Amenorrhea, Dysmenorrhoea, warming meridians and promoting circulation of qi.
Medicine of the present invention is the principle based on Chinese traditional treatment breast cancer, from the pathomechanism according to breast cancer and pharmacological action Think:With regard to breast cancer, each raw material herbal medicine efficacy in medicine provided by the present invention is played altogether, has good treatment to above-mentioned disease Effect.
Embodiment
A kind of Chinese medicine preparation that the present invention proposes aiming at the treatment of above-mentioned breast cancer, the medicine prepared using the formula Thing good drug efficacy, it is quick, it is a good Chinese prescription, is particularly suitable for Clinical practice.With reference to the specific reality of the present invention The mode of applying is described in further detail:
Embodiment 1:
A kind of capsule medicine for being used to treat breast cancer, it is characterised in that each component and mass parts of the medicine are such as Shown in lower:
Dandelion 140g, Chinese yew 120g, cepehalotaxus fortunei 170g, SHENLIUGU 80g, alstonia-leaf 95g, Paris polyphylla 70g, Chinese actinidia root 360g, Radix bupleuri 95g, fiery leaf 80g, thizoma curculiginis 70g, curcuma zedoary 95g, Chinese cassia tree 45g, auxiliary material:Appropriate starch.
Embodiment 2:
A kind of capsule medicine for being used to treat breast cancer, it is characterised in that each component and mass parts of the medicine are such as Shown in lower:
Dandelion 160g, Chinese yew 140g, cepehalotaxus fortunei 200g, SHENLIUGU 90g, alstonia-leaf 105g, Paris polyphylla 80g, Chinese actinidia root 420g, Radix bupleuri 105g, fiery leaf 90g, thizoma curculiginis 80g, curcuma zedoary 105g, Chinese cassia tree 52g, auxiliary material:Appropriate starch.
Embodiment 3:
A kind of capsule medicine for being used to treat breast cancer, it is characterised in that each component and mass parts of the medicine are such as Shown in lower:
Dandelion 180g, Chinese yew 160g, cepehalotaxus fortunei 220g, SHENLIUGU 100g, alstonia-leaf 120g, Paris polyphylla 90g, Chinese actinidia root 500g, radix bupleuri 120g, fiery leaf 100g, thizoma curculiginis 90g, curcuma zedoary 120g, Chinese cassia tree 60g, auxiliary material:Appropriate starch.
Model case
Through clinical conditions patient with breast cancer totally 950, the age is 550 of more than 38 years old, only 400 for 38 years old with Under.Being fully recovered in 950 patients and extending life cycle has 220, effective 397, invalid 333.Total effective rate reaches 65%。

Claims (3)

1. a kind of capsule medicine for being used to treat breast cancer, it is characterised in that each component and its mass parts of the medicine Than as follows:
90~180g of dandelion, 90~160g of Chinese yew, 150~220g of cepehalotaxus fortunei, 50~100g of SHENLIUGU, alstonia-leaf 50~ 120g, 30~90g of Paris polyphylla, 250~500g of Chinese actinidia root, 30~120g of radix bupleuri, fiery 30~100g of leaf, 30~90g of thizoma curculiginis, curcuma zedoary 30~120g, 15~60g of Chinese cassia tree, auxiliary material:Appropriate starch.
2. according to claim 1 be used to treat the capsule medicine of breast cancer, it is characterised in that the medicine it is each Component and its mass parts are than as follows:
100~160g of dandelion, 100~140g of Chinese yew, 160~200g of cepehalotaxus fortunei, 58~90g of SHENLIUGU, alstonia-leaf 58~ 105g, 38~80g of Paris polyphylla, 280~420g of Chinese actinidia root, 38~105g of radix bupleuri, fiery 38~90g of leaf, 38~80g of thizoma curculiginis, curcuma zedoary 38 ~105g, 20~52g of Chinese cassia tree, auxiliary material:Appropriate starch.
3. the capsule medicine for being used to treat breast cancer according to claim 1 to 2, it is characterised in that the medicine Each component and its mass parts are than as follows:
Dandelion 140g, Chinese yew 120g, cepehalotaxus fortunei 170g, SHENLIUGU 80g, alstonia-leaf 95g, Paris polyphylla 70g, Chinese actinidia root 360g, Radix bupleuri 95g, fiery leaf 80g, thizoma curculiginis 70g, curcuma zedoary 95g, Chinese cassia tree 45g, auxiliary material:Appropriate starch.
CN201711109328.7A 2017-11-11 2017-11-11 A kind of capsule medicine and preparation method for being used to treat breast cancer Withdrawn CN107802785A (en)

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