CN107802641A - Oral soft tissue (gum, mucous membrane) anti-inflammatory is ached agent - Google Patents

Oral soft tissue (gum, mucous membrane) anti-inflammatory is ached agent Download PDF

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CN107802641A
CN107802641A CN201610812313.6A CN201610812313A CN107802641A CN 107802641 A CN107802641 A CN 107802641A CN 201610812313 A CN201610812313 A CN 201610812313A CN 107802641 A CN107802641 A CN 107802641A
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foregoing
inflammatory
agent
acid
content
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李明典
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A61K33/10—Carbonates; Bicarbonates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Inorganic Chemistry (AREA)
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Abstract

A kind of oral soft tissue (gum, mucous membrane) anti-inflammatory is ached agent, is to include：More than one corticotropin or anti-inflammatory inhibiting compound, the long-acting adhesiveness of tool more than one adhesive polymers, one kind fills up maintenance agent and more than one additives mix a mixture；Wherein foregoing corticotropin or anti-inflammatory inhibiting compound content is 0.5~2 mass percent；Aforementioned adhesion polymer content is 1~4.5 mass percent；Foregoing maintenance agent content of filling up is 35~45 mass percents；Aforementioned additive content is 30~50 mass percents, pH-value indices P H6~8.5 of aforementioned mixture.

Description

Oral soft tissue (gum, mucous membrane) anti-inflammatory is ached agent
Technical field
The present invention provides the technical field that a kind of anti-inflammatory aches agent, and espespecially it technically provides a kind of oral soft tissue (gum, mucous membrane) anti-inflammatory is ached agent.
Background technology
It is known not have not identical or be similar to present inventor, it is also hereby the known patent description for oral cavity as an example.Such as Its Application No. the 102142948th " medical application of intraoral glue constituent set group ", it includes collutory, the collutory into Part includes water, sodium acid carbonate, saccharin sodium and micro menthol and food coloring blueness 1, and intraoral gel is in oral cavity The film of a protection oral mucosa is formed, external force stimulation can be reduced, thereby protect any mode to cause the mucous membrane of canker sore, subtract Slow mucous membrane produces violent pain because directly contacting.Wherein, the intraoral solidifying agent system includes water, polyvinylpyrrolidone K- 90th, calcium chloride, dipotassium glycyrrhizinate, benzalkonium chloride, disodium EDTA, potassium sorbate and propane diols；Also, match somebody with somebody Different component ratios is closed, is that can be used directly or be diluted with water use, right PVP K-90 has removing toxic substances, stopped Blood, concentration of ordinary dissolution is improved, peritoneal adhesion is prevented, promotes the effect such as erythrocyte sedimentation rate, for the cosolvent of the patent of the habit, calcium chloride is one kind Imported agent, it is hypercalcification though bone tooth calcification can be accelerated, it is counter to easily cause excessive tooth embrittlement, and then damage easily is collapsed, again Skill can cause the excessive abnormal activation of oral cavity muscle, and cause refreshing base muscle dysfunction, or weak and feeble, especially more quick to calcium chloride Sense person, relatively it is not suitable for using.And benzalkonium chloride is the disinfectant being commonly used, the concentration scope of standard for 0.004% to 0.01%, excessive concentration can produce corrosivity, be unable to reach the effect of calm anti-inflammatory on the contrary.And saccharin sodium more likely have it is carcinogenic Doubt and risk.
Only, foregoing known preceding case, it is to be used in the form of two doses, and foregoing known preceding case system makes as canker sore With.And the present invention is one form, the present invention aches uses as oral soft tissue (gum, mucous membrane) anti-inflammatory, it is of the invention and It is known and differ.
Therefore for the problems of above-mentioned known preparation point, a kind of innovation of more preferable practicality how is developed Preparation, real consumer eagerly look forward to, and are also target and direction that related dealer must make great efforts that research and development break through.
In view of this, inventor's sheet is in the manufacturing development and design experiences of being engaged in Related product for many years, for above-mentioned mesh Mark, is designed after being assessed with discretion in detail, obtains the present invention for really having practicality eventually.
The content of the invention
It is a primary object of the present invention to provide a kind of oral soft tissue (gum, mucous membrane) anti-inflammatory to ache agent, it is included More than one corticotropin or anti-inflammatory inhibiting compound, more than one adhesive polymers of the long-acting adhesiveness of tool, one Kind fills up maintenance agent and more than one additive mixes a mixture；Wherein foregoing corticotropin is anti- Scorching inhibiting compound content is 0.5~2 mass percent；Aforementioned adhesion polymer content is 1~4.5 mass percent；It is foregoing It is 35~45 mass percents to fill up maintenance agent content；Aforementioned additive content is 30~50 mass percents, aforementioned mixture PH-value indices P H6~8.5.
For the above-mentioned purpose, the present invention provides a kind of oral soft tissue (gum, mucous membrane) anti-inflammatory and ached agent, wherein foregoing Corticotropin or anti-inflammatory inhibiting compound are included selected from 3 beta-hydroxy -11- oxygen -12- oleanenes -30- acid, (20 β) -3 beta-hydroxy -11- oxygen Orion -12- oleanenes -29- acid, (3 β, 20 β) -3- hydroxyl -11- oxygen -12- oleanenes - 29- acid, deoxy-glycyrrhetinic acid (deoxyglycyr rhetic acid), 18 β-enoxolone, 18- Alpha-hydroxy enoxolones (dihydroxyglycyrrhetic acid are for (18- α-droxyglycyrrhetic a cid), dihydroxy enoxolone Grabric acid) and different enoxolone (liquiritic acid) compound form one of group or it is a kind of with On.
For the above-mentioned purpose, the present invention provides a kind of oral soft tissue (gum, mucous membrane) anti-inflammatory and ached agent, wherein foregoing Adhesive polymer includes a thickener and a silicate compound, and foregoing thickener is (Sodium Carboxymethyl Cellulose abbreviation NaCMC) sodium carboxymethylcellulose, the content of foregoing thickener is 0.5~2.5 mass percent, foregoing silicon Barbiturates compound is (SiO2) silica, the content of foregoing silicate compound is 0.5~2 mass percent.
For the above-mentioned purpose, the present invention provides a kind of oral soft tissue (gum, mucous membrane) anti-inflammatory and ached agent, wherein foregoing It is calcium carbonate (CaCO to fill up maintenance agent3)。
For the above-mentioned purpose, the present invention provides a kind of oral soft tissue (gum, mucous membrane) anti-inflammatory and ached agent, wherein foregoing Additive can include propane-1,2,3-triol glycerine (glycerine), (1R, 2S, 5R) -2-isopropyl-5- Methylcyclohexanol (1R, 2S, 5R) -2- isopropanol -5- methyl cyclohexanols (menthol) and pure water (Purified Water mixing additive), wherein foregoing propane-1, the content of 2,3-triol glycerine (glycerine) is 30~40 mass Percentage；Foregoing (1R, 2S, 5R) -2-isopropyl-5-methylcyclohexanol (1R, 2S, 5R) -2- isopropanols -5- The content of methyl cyclohexanol (menthol) is 0.3~1.3 mass percent.
For the above-mentioned purpose, the present invention provides a kind of oral soft tissue (gum, mucous membrane) anti-inflammatory and ached agent, wherein foregoing Additive can include more than one addition polymer, and foregoing addition polymer includes Coryophyllic acid (Eugenol eugenols) or propylparaben (Propyl paraben).
For the above-mentioned purpose, the present invention provides a kind of oral soft tissue (gum, mucous membrane) anti-inflammatory and ached agent, wherein foregoing Additive can include NaLS (Sodium Lauryl Sulfate), foregoing NaLS (Sodium Lauryl Sulfate) content is 0.5~3.5 mass percent.
For the above-mentioned purpose, the present invention provides a kind of oral soft tissue (gum, mucous membrane) anti-inflammatory and ached agent, wherein foregoing Additive can include fluorine compounds.
Relevant the technology used in the present invention, means and its effect, hereby lift a preferred embodiment and coordinate schema specifically It is bright in rear, it is believed that above-mentioned purpose, construction and the feature of the present invention, deeply specifically understand when one can be obtained by it.
Embodiment
Present invention system provides the designer that a kind of oral soft tissue (gum, mucous membrane) anti-inflammatory aches agent.
To enable your juror to have a better understanding and awareness the purpose of the present invention, feature and effect, hereby Embodiment and schema is coordinated to be described in detail as after：
The present invention provides a kind of oral soft tissue (gum, mucous membrane) anti-inflammatory and ached agent, is to include：
More than one corticotropin or anti-inflammatory inhibiting compound, more than one bondings of the long-acting adhesiveness of tool gather Compound, one kind fill up maintenance agent and more than one additives mix a mixture；Wherein foregoing corticotrophins Element or anti-inflammatory inhibiting compound content are 0.5~2 mass percent；Aforementioned adhesion polymer content is 1~4.5 mass percentage Than；Foregoing maintenance agent content of filling up is 35~45 mass percents；Aforementioned additive content is 30~50 mass percents, foregoing PH-value indices P H6~8.5 of mixture.
A kind of described oral soft tissue (gum, mucous membrane) anti-inflammatory is ached agent, wherein foregoing corticotropin Or anti-inflammatory inhibiting compound is included selected from 3 beta-hydroxy -11- oxygen -12- oleanenes -30- acid, (20 β) -3 beta-hydroxy -11- oxygen Austria The amp- 12- oleanenes -29- acid of profit, (3 β, 20 β) -3- hydroxyl -11- oxygen -12- oleanenes -29- acid, deoxy-glycyrrhetinic acid (deoxyglycyrrhetic acid), 18 β-enoxolone, 18- Alpha-hydroxies enoxolone (18- α- Droxyglycyrrhetic acid), (dihydroxyglycyrrhetic acid are grabric to dihydroxy enoxolone Acid) and different enoxolone (liquiritic acid) compound forms enoxolone (Enoxolone) group wherein One of or more than one.
A kind of described oral soft tissue (gum, mucous membrane) anti-inflammatory is ached agent, and wherein aforementioned adhesion polymer includes One thickener and a silicate compound, foregoing thickener is (Sodium Carbox ymethyl Cellulose are referred to as NaCMC) sodium carboxymethylcellulose, the content of foregoing thickener are 0.5~2.5 mass percent, foregoing silicate compound For (SiO2) silica, the content of foregoing silicate compound is 0.5~2 mass percent.
A kind of described oral soft tissue (gum, mucous membrane) anti-inflammatory is ached agent, wherein foregoing, to fill up maintenance agent be carbonic acid Calcium (CaCO3)。
A kind of described oral soft tissue (gum, mucous membrane) anti-inflammatory is ached agent, and wherein aforementioned additive can include Propane-1,2,3-triol glycerine (glycerine), (1R, 2S, 5R) -2-isopropyl-5-methylcyclohexanol The mixing additive of (1R, 2S, 5R) -2- isopropanol -5- methyl cyclohexanols (menthol) and pure water (Purified Water), its In the content of foregoing propane-1,2,3-triol glycerine (glycerine) be 30~40 mass percents；Foregoing (1R, 2S, 5R)- 2-isopropyl-5-methylcyclohexanol (1R, 2S, 5R) -2- isopropanol -5- methyl cyclohexanol (menthol) contains Measure as 0.3~1.3 mass percent.Pure water (Purified Water) acts on for humidity regulation of the present invention.
A kind of described oral soft tissue (gum, mucous membrane) anti-inflammatory is ached agent, and wherein aforementioned additive can include one kind Addition polymer above, foregoing addition polymer include Coryophyllic acid (Eugenol eugenols) or to hydroxyl Yl benzoic acid propyl ester (Propyl paraben).
A kind of described oral soft tissue (gum, mucous membrane) anti-inflammatory is ached agent, and wherein aforementioned additive can include bay Base sodium sulphate (Sodium Lauryl Sulfate), foregoing NaLS (Sodium Lauryl Sulfate) content are 0.5~3.5 mass percent.
A kind of described oral soft tissue (gum, mucous membrane) anti-inflammatory is ached agent, and wherein aforementioned additive can include fluorination Compound.
The present invention mainly can be as scorching and periodontal associated disease symptom reparation, increasing around gum, oral mucosa, implant Life, anti-inflammatory, sterilization, anti-inflammatory and other effects, it also has the function that viral infection resisting, to the virus of carcinogenicity such as hepatitis viruse, The infection of Epstein-Barr virus and AIDS virus has inhibitory action, and as similar to the pharmacology of antibioticses, and it is used to treat grape The infection of coccus, streptococcus, Escherichia coli, pylori etc. all has the effect in degree to produce.Its chemical constitution is consolidated with cortex Alcohols is similar.To adrenalectomize cortex and excision animal pituitary, enoxolone remain to produce sodium retention and antidiuresis and Antiinflammatory action, i.e. enoxolone inhibit the destruction of adrenal cortical steroid class in vivo, thus corticosteroid content in blood Corresponding increase, and obvious adrenocortical hormones fuction is presented, also with phenylbutazone (butazolidin) or hydrogenation can The antiinflammatory action of loose sample.There is inhibitory action for granuloma induced by implantation of cotton pellets and swollen, the subcutaneous granuloma inflammation of formaldehyde pin etc., it is anti- Scorching potency be about cortisone or hydrogenation can pine 1/10, therefore its pharmacological properties is for scorching around gum, oral mucosa, implant and tooth The associated disease symptoms such as week have good inhibition.
Calcium carbonate (Calcium Carbonate) is mainly used in stain, frosted, fills up dentine aperture, is resisted for one kind Quick, antiacid fills up agent.Calcium carbonate is a kind of inorganic compound, is commonly called as lime stone, lime stone, stone flour, marble, calcite, is A kind of compound, chemical formula are CaCO3, in alkalescence, it is substantially insoluble in, is dissolved in acid.It is Common materials on the earth, is existed In in the rocks such as aragonite, calcite, chalk, limestone, marble, calcareous tufa.Or the main component for animal skeleton or shell, Also it is conventional calcareous source, it is ground because it is the source of calcium also often as one of active ingredient in acid inhibitor Into after powder, be that stain-removing effect is good except the frosted for dental surface, can outside effectively pre- dental calculus preventing effect, Dentine aperture can be more filled up because of tool, dentine aperture is completely covered, can effectively be avoided in the dental nerve in dentine aperture It is exposed, and feel to ache by cold and hot food stimulus, be aching and limp.Be frosted, while going stain, more because with (Sodium Carboxymethyl Cellulose abbreviation NaCMC) sodium carboxymethylcellulose and (SiO2) silica adhesive polymer phase It is poly- and, thin film protective layer can be formed effective in dentine orifice surface, be for effective antiallergic, antiacid fill up agent.
Sodium carboxymethylcellulose (Sodium Carboxymethyl Cellulose abbreviation NaCMC) is carboxymethyl cellulose The sodium salt of ether, it is odorless, tasteless for white or milky fibrous powder or particle, have hygroscopicity.It is readily dispersed in Cheng Cheng in water Gelatin-like liquid, it is insoluble in the organic solvents such as ethanol.1% aqueous solution pH is 6.5~8.5, and as pH ＞ 10 or ＜ 5, rubber cement glues Degree significantly reduces, and in pH7, performance is optimal.To thermostabilization, viscosity rises rapidly below 20 DEG C, and change is slower at 45 DEG C, and 80 Long-time heating more than DEG C can make the denaturation of its colloid and viscosity is decreased obviously.226~228 DEG C of brown stain temperature, carburizing temperature 252~ 253℃.It is a kind of odorless, tasteless, tool hygroscopicity.It is readily dispersed in water into clear and bright colloidal fluid, in organic solvents such as ethanol In it is insoluble.According to《National food safety standard, food additives use standard》(GB2760-2011) provide：Make in food Used with thickener.Sodium carboxymethylcellulose (NaCMC) have emulsifying dispersant, solid dispersiveness, be not easy corruption, physiologically without Evil etc. is unusual and extremely valuable comprehensive physical, chemical property, be yield is maximum in cellulose ethers, purposes most Extensively, using product the most convenient, it is to form highly viscous colloid, solution, have adhesion, increase to be commonly called as " industrial monosodium glutamate " key property The characteristic such as thick, flowing, emulsion dispersion, figuration, water conservation, protecting colloid, film forming, acidproof, salt tolerant, suspended, and physiological harmlessness, Therefore it is used widely in fields such as food, medicine, daily use chemicals, oil, papermaking, weaving, buildings.Ache agent in this anti-inflammatory In, it is a kind of thickener, the effect that offer medicament is provided, and combined with silica (Silicone Dioxide), make it Produce and have certain viscosity, and then form gluey or paste formulation.Allow this medicament to can be used for the smearing of ointment, formed in affected part Protective film shape, or toothpaste state use.
Silica (Silicone Dioxide) is anti-caking agent and thickener.SiO2Network structure determine it have There are excellent physics and chemical property, plus SiO2In being widely present for nature, from ancient times to the present all widely applied by the mankind .Silica melts at high temperature with other compounds, and glass can be made in quick cooling.It is also the master of sand and quartz Want composition.It is raw material main at present in the application such as semiconductor and solar panels, is used as anticaking agent, category food in food industry The row of product additive, it is to prevent between food and food, or is adhered between food and packaging.It may add in any powdery Flavoring, brew bag, salt, section cheese etc..Because such a mineral very fine powder, there is the effect of lubrication.So it can protect The loose state of powdery type maintenance is held without luming, in addition, its function medically is crosslinking agent, it is possible to provide intensity, flexibility, Making collagen and connective tissue, silica is proved under study for action can be in bone, arterial wall, skin, tooth with elasticity Integrality plays a role in tooth, gum, hair and nail, and be used to alleviate eczema and psoriasis.Research is currently true Silica is determined for whetheing there is effect in rheumatic disease and arterial disease.Silica can prevent osteoporosis, strengthen Musculoskeletal system, therefore can avoid much injuring, it can also accelerate the healing of fracture, and silica can help structure base The formation of body and reparation connective tissue, mineral matter contribute to the growth of human body in the accumulation of matrix.Silica be it is basic, It is responsible for the deposition of calcium and the phosphate albumen substrate of bone in Gegenbaur's cell.It is (soft through studies have shown that skeletal diseases such as osteomalacia Bone) and osteoporosis (or spontaneous fracture), although caused by the deficiency of calcium, single can not be treated based on calcium. Calcium adds silica, works well, therefore, coordinate calcium carbonate, dentine aperture is filled up, or protective layer is formed on surface Effect has excellent antiallergic, antiacid performance.
Glycerine (propane-1,2,3-triol) is glycerine (Glycerin), is a kind of water-loss reducer and antifreezing agent.Third Triol is the framework ingredient of triglycerides molecule.When human body takes in edible fat, triglycerides therein is by metabolism in vivo Decompose, form glycerine and be stored in adipocyte.Therefore, the final product of Triglyceride Metabolism in Patients is glycerine and aliphatic acid. It can be used as solvent, lubricant, medicament and sweetener, it is the pleasantly sweet thick liquid of no color or smell, proportion 1.2613 (20/ 4 °), 290 DEG C of boiling point.Can be miscible in any proportion with water, there is great hygroscopicity, be slightly dissolved in ethanol and ether, insoluble in chlorine It is imitative.Glycerine can be used for manufacturing nitroglycerine, alkyd resin etc..It also is used as the antifreeze of aircraft and vehicle liquid fuel, glass, The hygroscopic agent of the plasticizer and cosmetics of paper, leather, tobacco, textile etc..It can be used to preserve sample in the lab, its Body has sweet taste, can have good mouthfeel and lubrication sense when oral cavity affected part is smeared.
(1R, 2S, 5R) -2- isopropanol -5- methyl cyclohexanols are Menthol menthols：It is refrigerant, calm, make implication clear Newly, smelly eliminating.Menthol manufactures in peppermint blade, that is, the main component of peppermint oil, is one kind of ring monoterpenoid.It is High volatile essential oil caused by plant, its composition are mostly hemiterpene, monoterpene and sequiterpene, and yield is more especially in warmer climate It is high.Some important phytochromes are the compounds of terpenoid or the base containing terpenoid.It has antipruritic, analgesic, anti-corrosion, stimulation, anesthesia, Refrigerant and antiinflammatory action, headache, neuralgia, itch and respiratory inflammation, atrophic rhinitis, celostomia etc. can be controlled, can eliminated again different Taste, this agent is set to lift its comfort.
Coryophyllic acid is Eugenol eugenols：It is a kind of organic compound, is present in more plantations In thing, rich in its essential oil, such as oreodaphene.With durable aroma, frequently as the spices of perfumed soap.It is colourless to faint yellow micro- thick Thick liquid, have strong cloves smell, be mainly used in antibacterial, hypotensive, local anesthetic, be also used for manufacturing perfume, essence, essence Oil, dressing agent and fixastive.It can be used as arranging in pairs or groups with host enoxolone in this agent, reach quick anti-inflammatory, the effect of antibacterial, Itself has the characteristic of local anaesthesia again, oral soft tissue (gum, mucous membrane) can be made to feel to releive rapidly, analgesic effect.Again Available for carious tooth, and have local antisepsis concurrently, be to speed effect, and one of optimal additive of the comfortable body-sensing of increase.
Propylparaben (Propyl paraben) is a kind of preservative being used in cosmetics and pharmaceutical industries, Also it is commonly used in food additives, its salt and compound is initially then used as bactericidal and fungicide.Moisten in shampoo, business Such compound is commonly used in skin cream, shaving cream, human body lubricants, topical drug, spraying solvent, cosmetics and toothpaste.Its There is extensive antibacterial action for mould, yeast and bacterium.This agent is set to improve its antiseptic power and dissolubility.
NaLS (Sodium Lauryl Sulfate) also known as lauryl sodium sulfate (Sodiumdodecyl Sulfate), it is one of conventional surfactant, is a kind of anion surfactant, belongs to sulfuric acid ester surfactant Typical Representative, be slightly soluble in alcohol, it is soluble in water insoluble in chloroform, ether, it is good with anion, the multiple compatibility of nonionic, have good Emulsibility, foaming characteristic, foaming, infiltration, decontamination and dispersive property, Pao Droplets enrich, it is biodegradable fast, be widely used in tooth Foaming agent in cream, soap, bath oil, shampoo, washing powder, and cosmetics.Maintenance can be used as and filled up in this agent The calcium carbonate of agent goes stain, the strengthening action of cleaning, after removing the dirty thing in oral cavity, allows the calcium carbonate for filling up maintenance agent to be repaiied The effect mended and protected.
It is to be specifically described for technical characteristic of the presently preferred embodiments of the present invention for the present invention above；Only, it is familiar with The personage of technique, which works as, not to depart from spirit of the invention with the present invention is changed and changed under principle, and such change More with modification, should all be covered by the category that following claim is defined.
In summary, present invention system provides a kind of oral soft tissue (gum, mucous membrane) anti-inflammatory and ached agent, and it indeed reaches The all purposes of the present invention, the space kenel of its another combining structure are not found in like product, before not also being disclosed in application, accorded with The regulation of Patent Law is closed, whence is filed an application in accordance with the law.

Claims (4)

  1. The agent 1. a kind of oral soft tissue (gum, mucous membrane) anti-inflammatory is ached, it is included：
    More than one corticotropin or anti-inflammatory inhibiting compound, more than one adhesion to polymeric of the long-acting adhesiveness of tool Thing, one kind fill up maintenance agent and more than one additives mix a mixture；Wherein foregoing corticotropin Or anti-inflammatory inhibiting compound content is 0.5~2 mass percent；Aforementioned adhesion polymer content is 1~4.5 mass percent； Foregoing maintenance agent content of filling up is 35~45 mass percents；Aforementioned additive content is 30~50 mass percents, foregoing mixed PH-value indices P H6~8.5 of compound；
    Wherein foregoing corticotropin or anti-inflammatory inhibiting compound include and are selected from 3 beta-hydroxy -11- oxygen -12- olives Alkene -30- acid, (20 β) -3 beta-hydroxy -11- oxygen Orion -12- oleanenes -29- acid, (3 β, 20 β) -3- hydroxyl -11- oxygen - 12- oleanenes -29- acid, deoxy-glycyrrhetinic acid (deoxyglycyrrhetic acid), 18 β-enoxolone, 18- Alpha-hydroxies Enoxolone (18- α-droxyglycyrrhetic acid), dihydroxy enoxolone (dihydroxyglycyrrhetic Acid is grabric acid) and different enoxolone (liquiritic acid) compound form enoxolone (Enoxolone) one of group or more than one；
    Wherein aforementioned adhesion polymer includes a thickener and a silicate compound, and foregoing thickener is (NaCMC) carboxylic Sodium carboxymethylcellulose pyce, the content of foregoing thickener is 0.5~2.5 mass percent, and foregoing silicate compound is (SiO2) Silica, the content of foregoing silicate compound is 0.5~2 mass percent；
    It is wherein foregoing that to fill up maintenance agent be calcium carbonate (CaCO3)；
    Wherein aforementioned additive can include propane-1,2,3-triol glycerine (glycerine), (1R, 2S, 5R) -2- Isopropyl-5-methylcyclohexanol (1R, 2S, 5R) -2- isopropanol -5- methyl cyclohexanols (menthol) and pure water The mixing additive of (Purified Water), wherein foregoing propane-1, the content of 2,3-triol glycerine (glycerine) are 30~40 mass percents；Foregoing (1R, 2S, 5R) -2-isopropyl-5-methylcyclohexanol (1R, 2S, 5R) -2- The content of isopropanol -5- methyl cyclohexanols (menthol) is 0.3~1.3 mass percent.
  2. The agent 2. a kind of oral soft tissue (gum, mucous membrane) anti-inflammatory as claimed in claim 1 is ached, wherein aforementioned additive can More than one addition polymer is included, foregoing addition polymer includes Coryophyllic acid (Eugenol cloves Phenol) or propylparaben (Propyl paraben).
  3. The agent 3. a kind of oral soft tissue (gum, mucous membrane) anti-inflammatory as claimed in claim 1 is ached, wherein aforementioned additive can Include NaLS (Sodium Lauryl Sulfate), foregoing NaLS (Sodium Lauryl Sulfate) content is 0.5~3.5 mass percent.
  4. The agent 4. a kind of oral soft tissue (gum, mucous membrane) anti-inflammatory as claimed in claim 1 is ached, wherein aforementioned additive can Include fluorine compounds.
CN201610812313.6A 2016-09-09 2016-09-09 Oral soft tissue (gum, mucous membrane) anti-inflammatory is ached agent Pending CN107802641A (en)

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Citations (5)

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CN1203806A (en) * 1997-06-26 1999-01-06 富光药品工业株式会社 Composition for preventing and curing gingivitis
CN1474700A (en) * 2000-07-28 2004-02-11 ������ҩ�����޹�˾ Pharmaceutical compositions for treatment of mucositis, stomatitis and Behchet's syndrome
EP1446167A2 (en) * 2001-11-05 2004-08-18 Orahealth Corporation Treating canker sores with patches to speed healing and relieve pain
CN101370475A (en) * 2005-11-25 2009-02-18 “Wds”公司 Treating and preventing preparation used for oral nursing
CN105142607A (en) * 2013-03-27 2015-12-09 狮王株式会社 Composition for oral cavity

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1203806A (en) * 1997-06-26 1999-01-06 富光药品工业株式会社 Composition for preventing and curing gingivitis
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