CN107801714A - A kind of niclosamidum floating on water diffusion pulvis and preparation method thereof - Google Patents
A kind of niclosamidum floating on water diffusion pulvis and preparation method thereof Download PDFInfo
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- CN107801714A CN107801714A CN201710880517.8A CN201710880517A CN107801714A CN 107801714 A CN107801714 A CN 107801714A CN 201710880517 A CN201710880517 A CN 201710880517A CN 107801714 A CN107801714 A CN 107801714A
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- Prior art keywords
- floating
- niclosamidum
- water
- pulvis
- water diffusion
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Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/12—Powders or granules
- A01N25/14—Powders or granules wettable
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/08—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing solids as carriers or diluents
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/36—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
- A01N37/38—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids having at least one oxygen or sulfur atom attached to an aromatic ring system
- A01N37/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids having at least one oxygen or sulfur atom attached to an aromatic ring system having at least one carboxylic group or a thio analogue, or a derivative thereof, and one oxygen or sulfur atom attached to the same aromatic ring system
Abstract
The present invention relates to technical field of pesticide, especially a kind of niclosamidum floating on water diffusion pulvis and preparation method thereof, including niclosamidum 1 10%, oily matter 2 10%, diffusant 5 20%, adsorption stuffing 1 10%, floating substance supplies 100%, is using the beneficial effect of technical scheme:1st, it is easy to use due to being packed using water-soluble bag, it can throw in water body, this point is more advantageous than film-spreading oil solution;2nd, efficiency high lower than floating particle agent production cost;3rd, after water body is thrown, after the dissolving of water-soluble bag, powder can be spread rapidly after meeting water to surrounding, and active ingredient is evenly distributed on the water surface, can effectively kill cercaria effect;4th, due in preparation be free of hazardous solvent, prevention effect is good, effective ingredient consumption is small, will not to water body produce pollution, therefore, niclosamidum floating on water diffusion pulvis should be prevent and treat cercaria another Labor-saving novel form.
Description
Technical field
The present invention relates to technical field of pesticide, especially a kind of niclosamidum floating on water diffusion pulvis and its preparation side
Method.
Background technology
Japanese schistosomiasis is to have a strong impact on the infectious parasitic of our people's health.The blood reached maturity is inhaled
Worm cercaria escapes from infection oncomelania, once people and animals' Human Water Contact, cercaria invasion then easy infection snail fever, it was reported that 98% with
On schistosoma japonicum cercariae be static state on the water surface, therefore the water surface kill cercaria be control blood fluke infect key measure.
Niclosamidum is the choice drug of spiral shell of going out, and is the molluscacide that onsite application is uniquely recommended by the World Health Organization, has
Spiral shell effect of going out is good, the advantage such as low to mammal and phytotoxicity, at the same to blood fluke cercaria have kill effect, at present
Killing oncomelania and cercaria formulation are largely wettable powder, suspending agent, granule, film-spreading oil solution, are also had been reported that using floating
Granule, traditional controlling mode hangs pack mode using wettable powder, suspending agent sprays, and these controlling modes, decoction is all difficult to
The uniform spread water surface, it is bad to cercaria prevention effect, and preventing and treating is wasted time and energy, in-convenience in use, although film-spreading oil solution is compared with other
Formulation preventing and treating cercaria effect is good, using relatively convenient, but film-spreading oil solution contains the easy polluted-water of solvent, as floating particle agent
Its complex process, production cost is higher, causes to be difficult to promote the use of.
The content of the invention
The technical problem to be solved in the present invention is:Overcome deficiency of the prior art, there is provided one kind is easy to use, is produced into
This is low, insecticide efficiency is high, the niclosamidum floating on water of safety and environmental protection diffusion pulvis.
In order to solve the above technical problems, the technical solution adopted by the present invention is as follows:
A kind of niclosamidum floating on water spreads pulvis, including niclosamidum 1-10%, oily matter 2-10%, diffusant
5-20%, adsorption stuffing 1-10%, floating substance supply 100%.
Preferably, the oily matter is from white oil, soybean oil, methyl oleate, one kind of pine nut base vegetable oil.Paraffin,
One or more in alkyl fatty esters, glyceride, animal tallow, vegetable oil, bobbin oil.
Preferably, the diffusant is castor oil polyoxyethylene ether, AEO, three phenethyl phenol polyoxy second
Alkene ether, sulphosuccinates, polyoxyethylene polyoxypropylene base ether block copolymers.
Preferably, the adsorption stuffing is hydrophobic adsorption filler.
Preferably, the hydrophobic adsorption filler is hydrophobic silica, calcium stearate, magnesium stearate.
Preferably, one kind that the floating substance is selected in hollow glass bead and perlite.
A kind of preparation method of niclosamidum floating on water diffusion pulvis, diffusant is mixed with oily matter, Ran Houyou
Adsorbent is adsorbed, then is sufficiently mixed with the niclosamide active compound after air-flow crushing, floating substance by mixer.
Preferably, the niclosamidum floating on water diffusion pulvis is packed using water-soluble bag.
It is using the beneficial effect of technical scheme:
1st, it is easy to use due to being packed using water-soluble bag, it can throw in water body, this point is more advantageous than film-spreading oil solution;
2nd, efficiency high lower than floating particle agent production cost;
3rd, after water body is thrown, after the dissolving of water-soluble bag, powder can spread rapidly after meeting water to surrounding, and active ingredient is uniform
It is distributed on the water surface, can effectively kills cercaria effect;
4th, due to being free of hazardous solvent in preparation, prevention effect is good, effective ingredient consumption is small, water body will not be produced dirty
Dye, therefore, niclosamidum floating on water diffusion pulvis should be another the Labor-saving novel form for preventing and treating cercaria.
Embodiment
In order to deepen the understanding of the present invention, below in conjunction with embodiment, the invention will be further described, these implementations
Example is only used for explaining the present invention, is not intended to limit the scope of the present invention..
Embodiment 1
By weight/mass percentage composition take 2% soybean oil mixed with 5% AEO after with 5% hydrophobicity titanium dioxide
Silicon is adsorbed, then high-speed mixer is transferred to after being mixed with 1% niclosamide active compound, the hollow glass bead after air-flow crushing and is fully mixed
Close, that is, 1% niclosamidum floating on water diffusion pulvis is made.
Embodiment 2
By weight/mass percentage composition take 5% white oil mixed with 8% castor oil polyoxyethylene ether after with 10% calcium stearate adsorb,
High-speed mixer is transferred to after mixing with 2% niclosamide active compound, the perlite after air-flow crushing again to be sufficiently mixed, that is, is made
2% niclosamidum floating on water spreads pulvis.
Embodiment 3
By weight/mass percentage composition take 10% pine nut vegetable oil mixed with 20% sulphosuccinates after with 10% stearic acid
Magnesium is adsorbed, then high-speed mixer is transferred to after being mixed with 3% niclosamide active compound, the hollow glass bead after air-flow crushing and is fully mixed
Close, that is, 3% niclosamidum floating on water diffusion pulvis is made.
Embodiment 4
8% soybean oil is taken to be used after being mixed with 15% polyoxyethylene polyoxypropylene base ether block copolymers by weight/mass percentage composition
8% hydrophobic silica adsorbs, then is transferred to after being mixed with 10% niclosamide active compound, the hollow glass bead after air-flow crushing
High-speed mixer is sufficiently mixed, that is, 10% niclosamidum floating on water diffusion pulvis is made.
Embodiment 5
By weight/mass percentage composition take 2% methyl oleate mixed with 5% 3 phenethyl phenol polyethenoxy ether after with 1% hydrophobicity
Silica adsorbs, then is transferred to high-speed mixer after being mixed with 7% niclosamide active compound, the hollow glass bead after air-flow crushing
It is sufficiently mixed, that is, 7% niclosamidum floating on water diffusion pulvis is made.
Niclosamidum floating on water in embodiment 1-5 spreads pulvis in use, being packed using water-soluble bag, using water
Molten bag is packed, and can pinpoint dispensing during use.
Embodiment 6
Indoor 2% niclosamidum floating on water diffusion pulvis kills schistosoma japonicum cercariae experiment
The work cercaria 20-50 bars newly escaped are added with oese to be positioned in 6 hole Bacteria Culture plates, it is flat per hole area 9.5
Square centimetre, compared with dechlorination running water, 2% niclosamidum exhibition floating on water diffusion pulvis prepared by embodiment 2 is added per hole
0.25g, 0.5g, 1g, 2g, 3g, it is repeated 4 times.Survival condition of the Microscopic observation cercaria in each concentration group decoction is being dissected, with tail
The larva of a tapeworm or the cercaria of a schistosome, which expands and throws away motionless person through fine needle stimulation, is set to death.As a result it is as follows:
Medicinal powder is applied by dosage, is spread rapidly in the water surface, 1g/9.5cm2Dosage can effectively kill tail within lower 10 minutes
The larva of a tapeworm or the cercaria of a schistosome, more than 90% controls, and dosage increasing insect killing effect is better, so life habit and chlorine nitre willow with reference to schistosoma japonicum cercariae
Amine floating on water spreads the characteristics of pulvis, the method for proposing a new preventing and treating cercaria, dosage, root is calculated according to water surface area
According to result of the test, every square metre of 3-4 milliliters (30 milligrams) can effectively controls cercaria.Niclosamidum is studied according to Cao Guoqun etc.
Water body concentration reach 0.3mg/L continuous contacts 0.5h can 100% kill cercaria, according to 1 meter of deep water body calculate every square metre with
Amount, which reaches 300 milligrams, can effectively control cercaria, after carrying out improving dosage form, greatly reduce dosage, active ingredient also only exists
In water surface, the acute toxicity to fish etc. is reduced.
Experimental method refers to:A kind of niclosamidum film-spreading oil solution and preparation method thereof and application (CN102047881A)
It is complete by above-mentioned description, relevant staff using the above-mentioned desirable embodiment according to the present invention as enlightenment
Various changes and amendments can be carried out without departing from the scope of the technological thought of the present invention' entirely.The technology of this invention
Property scope is not limited to the content on specification, it is necessary to determines its technical scope according to right.
Claims (9)
1. a kind of niclosamidum floating on water spreads pulvis, it is characterised in that:Including niclosamidum 1-10%, oily matter 2-
10%, diffusant 5-20%, adsorption stuffing 1-10%, floating substance supply 100%.
A kind of 2. niclosamidum floating on water diffusion pulvis according to claim 1, it is characterised in that:The niclosamidum
For the niclosamidum obtained after air-flow crushing.
A kind of 3. niclosamidum floating on water diffusion pulvis according to claim 1, it is characterised in that:The oily matter
From white oil, soybean oil, methyl oleate, pine nut base vegetable oil one kind.
A kind of 4. niclosamidum floating on water diffusion pulvis according to claim 1, it is characterised in that:The diffusant choosing
With castor oil polyoxyethylene ether, AEO, three phenethyl phenol polyethenoxy ethers, sulphosuccinates, polyoxy
One kind in ethene polyoxypropylene base ether block copolymers.
A kind of 5. niclosamidum floating on water diffusion pulvis according to claim 1, it is characterised in that:The adsorption stuffing
For hydrophobic adsorption filler.
A kind of 6. niclosamidum floating on water diffusion pulvis according to claim 5, it is characterised in that:The hydrophobicity is inhaled
Attached filler is from one kind in hydrophobic silica, calcium stearate, magnesium stearate.
A kind of 7. niclosamidum floating on water diffusion pulvis according to claim 1, it is characterised in that:The floating substance
From one kind in hollow glass bead and perlite.
A kind of 8. preparation method of niclosamidum floating on water diffusion pulvis, it is characterised in that:Diffusant and oily matter are mixed
Close, then adsorbed by adsorbent, then it is abundant by mixer with the niclosamide active compound after air-flow crushing, floating substance
Mixing.
A kind of 9. preparation method of niclosamidum floating on water diffusion pulvis according to claim 8, it is characterised in that:Institute
Niclosamidum floating on water diffusion pulvis is stated to be packed using water-soluble bag.
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CN201710880517.8A CN107801714A (en) | 2017-09-26 | 2017-09-26 | A kind of niclosamidum floating on water diffusion pulvis and preparation method thereof |
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CN201710880517.8A CN107801714A (en) | 2017-09-26 | 2017-09-26 | A kind of niclosamidum floating on water diffusion pulvis and preparation method thereof |
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Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030198659A1 (en) * | 2001-10-25 | 2003-10-23 | Hoffmann Michael P. | Fibrous pest control |
CN1620867A (en) * | 2004-10-16 | 2005-06-01 | 江苏省血吸虫病防治研究所 | Niclosamide ethanolamine salt powder and its preparation method |
CN1720795A (en) * | 2004-07-14 | 2006-01-18 | 范小林 | Water surface floated sustained-release medicament for preventing and treating blood fluke and method for preparing the same |
CN101366376A (en) * | 2008-09-22 | 2009-02-18 | 扬州绿源生物化工有限公司 | Niclosamide controlled release dispersing agent for killing blood fluke cercaria and preparation method thereof |
CN103688971A (en) * | 2013-12-20 | 2014-04-02 | 南京高正农用化工有限公司 | Weeding macro granule for paddy field and preparation method thereof |
-
2017
- 2017-09-26 CN CN201710880517.8A patent/CN107801714A/en active Pending
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030198659A1 (en) * | 2001-10-25 | 2003-10-23 | Hoffmann Michael P. | Fibrous pest control |
CN1720795A (en) * | 2004-07-14 | 2006-01-18 | 范小林 | Water surface floated sustained-release medicament for preventing and treating blood fluke and method for preparing the same |
CN1620867A (en) * | 2004-10-16 | 2005-06-01 | 江苏省血吸虫病防治研究所 | Niclosamide ethanolamine salt powder and its preparation method |
CN101366376A (en) * | 2008-09-22 | 2009-02-18 | 扬州绿源生物化工有限公司 | Niclosamide controlled release dispersing agent for killing blood fluke cercaria and preparation method thereof |
CN103688971A (en) * | 2013-12-20 | 2014-04-02 | 南京高正农用化工有限公司 | Weeding macro granule for paddy field and preparation method thereof |
Non-Patent Citations (2)
Title |
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农药规格专家小组: "《粮农组织植保产品规格的制定和使用手册》", 30 November 2000, 中国农业科技出版社 * |
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CB02 | Change of applicant information |
Address after: 210000 No.65 shuangxiang Road, Xiongzhou street, Liuhe District, Nanjing City, Jiangsu Province Applicant after: Jiangsu Aijin crop Technology Group Co.,Ltd. Address before: 210000 58 Hongxiang Road, Hongshan Fine Chemical Park, Liuhe District, Nanjing, Jiangsu. Applicant before: JIANGSU ESSENCE AGROCHEMICAL Co.,Ltd. |
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Application publication date: 20180316 |