CN107779672A - Neurologic defect reparation degradable kirsite nerve trachea and preparation method thereof - Google Patents
Neurologic defect reparation degradable kirsite nerve trachea and preparation method thereof Download PDFInfo
- Publication number
- CN107779672A CN107779672A CN201610756193.2A CN201610756193A CN107779672A CN 107779672 A CN107779672 A CN 107779672A CN 201610756193 A CN201610756193 A CN 201610756193A CN 107779672 A CN107779672 A CN 107779672A
- Authority
- CN
- China
- Prior art keywords
- nerve trachea
- kirsite
- nerve
- neurologic defect
- hole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22C—ALLOYS
- C22C18/00—Alloys based on zinc
- C22C18/02—Alloys based on zinc with copper as the next major constituent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/04—Metals or alloys
- A61L27/047—Other specific metals or alloys not covered by A61L27/042 - A61L27/045 or A61L27/06
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/58—Materials at least partially resorbable by the body
-
- C—CHEMISTRY; METALLURGY
- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22C—ALLOYS
- C22C18/00—Alloys based on zinc
-
- C—CHEMISTRY; METALLURGY
- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22F—CHANGING THE PHYSICAL STRUCTURE OF NON-FERROUS METALS AND NON-FERROUS ALLOYS
- C22F1/00—Changing the physical structure of non-ferrous metals or alloys by heat treatment or by hot or cold working
- C22F1/16—Changing the physical structure of non-ferrous metals or alloys by heat treatment or by hot or cold working of other metals or alloys based thereon
- C22F1/165—Changing the physical structure of non-ferrous metals or alloys by heat treatment or by hot or cold working of other metals or alloys based thereon of zinc or cadmium or alloys based thereon
-
- C—CHEMISTRY; METALLURGY
- C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
- C23F—NON-MECHANICAL REMOVAL OF METALLIC MATERIAL FROM SURFACE; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL; MULTI-STEP PROCESSES FOR SURFACE TREATMENT OF METALLIC MATERIAL INVOLVING AT LEAST ONE PROCESS PROVIDED FOR IN CLASS C23 AND AT LEAST ONE PROCESS COVERED BY SUBCLASS C21D OR C22F OR CLASS C25
- C23F17/00—Multi-step processes for surface treatment of metallic material involving at least one process provided for in class C23 and at least one process covered by subclass C21D or C22F or class C25
-
- C—CHEMISTRY; METALLURGY
- C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
- C23G—CLEANING OR DE-GREASING OF METALLIC MATERIAL BY CHEMICAL METHODS OTHER THAN ELECTROLYSIS
- C23G1/00—Cleaning or pickling metallic material with solutions or molten salts
- C23G1/14—Cleaning or pickling metallic material with solutions or molten salts with alkaline solutions
- C23G1/20—Other heavy metals
-
- C—CHEMISTRY; METALLURGY
- C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
- C25F—PROCESSES FOR THE ELECTROLYTIC REMOVAL OF MATERIALS FROM OBJECTS; APPARATUS THEREFOR
- C25F3/00—Electrolytic etching or polishing
- C25F3/16—Polishing
- C25F3/22—Polishing of heavy metals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/32—Materials or treatment for tissue regeneration for nerve reconstruction
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Metallurgy (AREA)
- Materials Engineering (AREA)
- Mechanical Engineering (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Dermatology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Electrochemistry (AREA)
- Physics & Mathematics (AREA)
- Thermal Sciences (AREA)
- Crystallography & Structural Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention discloses a kind of neurologic defect reparation degradable kirsite nerve trachea and preparation method thereof；The nerve trachea is tubular type, and multiple row through hole is provided with the nerve trachea tube wall, and each column through hole is axially equidistantly arranged along pipe, the through hole Heterogeneous Permutation of adjacent column；There is a pair of a diameter of 0.3 0.5mm macropore at the both ends of the nerve trachea respectively.The present invention is uniformly distributed a number of hole in catheter wall, the peripheral nerve for being advantageous to defect exchanges with the nutrition that tube wall outside is organized, catheter wall is distributed the effect that a number of hole also acts as regulation and control degradation rate simultaneously, is advantageously implemented the matching of nerve regneration required time and conduit degradation time.The invention provides a kind of tissue-engineered bioartificial nerve graft built by degradable kirsite conduit to bridge the clinical treatment of reparation neurologic defect.
Description
Technical field
The present invention relates to biomaterial manufacture field, specially a kind of neurologic defect reparation is refreshing with degradable kirsite
Through conduit and preparation method thereof.
Background technology
Clinically the material of peripheral nerve defection reparation is frequently with autologous tissue (such as nerve, blood vessel, acellular matrix etc.),
But autologous tissue's limited source, and the permanent damage for area can be caused.The engineered artificial god built by conduit
Through repairing the treatment method that neurologic defect is most prospect to bridge.The conduit applied to CO2 laser weld is concentrated mainly on height at present
Molecularly Imprinted Polymer, natural biologic material, although these material biocompatibilities are excellent, catabolite easily causes group around
The inflammatory reaction and tube wall knitted collapse, and tube wall permeability is bad, and degradation time is difficult to accuracy controlling, are unfavorable for neural axon again
It is raw.Therefore clinically also it is widely adopted without a kind of preferably nerve trachea material.
With the progress of material science, the research and development of degradable metal sill are advanced by leaps and bounds.For example, degradable magnesium alloy blood
Pipe holder is applied to human body.But magnesium alloy degradation rate is very fast, bubble hydrogen easily is produced in implant site, is unfavorable for group
The reparation knitted.The same kirsite with good biocompatibility, its degradation rate are substantially less than magnesium alloy, not had in degradation process
There is obvious hydrogen to generate, and with fusing point is low, can not burn, suitable mechanical property, pipe walls support effect is strong, degraded speed
The advantages that rate is controllable, and catabolite is human essential elementses.Using Laser Processing 3-D technology, porous group can be accurately prepared
Weaver's journey tubular metal support, three-dimensional rack is provided for cell growth.However, because kirsite is as degradable medical metal
Research started to walk than magnesium alloy it is late, on kirsite deformation mechanism understanding not as good as magnesium alloy, and due to kirsite performance and
Properties of Magnesium Alloy has difference, such as zinc alloy material drawing hardening effect causes kirsite hair far away from magnesium alloy etc.
The processing and preparation of tubule material are rarely reported, and kirsite is applied to prepare nerve trachea and also have no report.
Based on this, the present invention proposes to apply degradable metal first on the basis of prepared by research and development kirsite capillary tubes
Conduit prepared by Zr-based materials is used for the reparation of peripheral nerve defection as nerve trachea, to solve nerve clinically used at present
The problem of impairment renovation material curative effect is undesirable.
The content of the invention
For in the prior art the defects of, it is an object of the invention to provide a kind of neurologic defect reparation with degradable kirsite
Nerve trachea and preparation method thereof.
The purpose of the present invention is achieved through the following technical solutions：
Led in a first aspect, the present invention provides a kind of neurologic defect reparation with degradable kirsite nerve trachea, the nerve
Manage as tubular type, multiple row through hole is provided with the nerve trachea tube wall, each column through hole is adjacent along pipe axially equidistantly arrangement
The through hole Heterogeneous Permutation of row；There is a pair of a diameter of 0.3-0.5mm macropore at the both ends of the nerve trachea respectively.The macropore is used
With banding fixed nerve.
Preferably, the kirsite includes Zn-Cu, Zn-Li bianry alloys, or Zn-Cu-Fe, Zn-Cu-Mg, Zn-Cu-
At least one of RE ternary alloy three-partalloys.
Preferably, in the kirsite, Zn content is more than 90wt%, and remaining is useful alloy element Cu, Li, Mg, Fe,
One or more in RE etc..Zn contents are relatively low, and kirsite corrosion degradation speed can be caused too fast.
Preferably, the length of the nerve trachea is 5~50mm, and the thickness of the nerve trachea is 0.05~0.2mm, institute
The aperture for stating through hole is 0.05~0.5mm, and the porosity of the nerve trachea is 5~25%.Porosity, which reduces, then increases conduit
Intensity and extend the corrosion degradation time, the reparation of peripheral nerve defection is easy in the conveying that porosity height is advantageous to nutriment.
Second aspect, the preparation side the invention provides a kind of neurologic defect reparation with degradable kirsite nerve trachea
Method, methods described comprise the following steps：
Step 1, by processing through hole among cylindrical kirsite blank, hot extrusion is carried out, obtains seamless kirsite intervalve
Material；
Step 2, by tubing among kirsite after the rolling of multi-pass normal temperature or normal temperature drawing, obtain capillary；
Step 3, capillary is subjected to annealing heat-treats, be cut by laser, punching, obtain multiholed catheter；
Step 4, by multiholed catheter, the pickling in supersonic cleaning machine, electrochemical polishing treatment, produces and is repaiied for neurologic defect
Multiple degradable kirsite nerve trachea.
Preferably, in step 1, the kirsite blank diameter isExtremelyThrough-hole diameter is processed among blank
ForExtremelyThe extrusion temperature is 150~280 DEG C, and extrusion temperature is too low or too high can all cause to extrude
During be difficult to shape；The external diameter of tubing is among the kirsiteWall thickness is 0.1~1mm, in mould before hot extrusion
Lubricant is sprayed on tool and the inside and outside wall of kirsite pipe.
Preferably, in step 2, the external diameter of the capillary is 1~4mm, and wall thickness is 0.05~0.2mm.
Preferably, in step 3, the temperature for going annealing heat-treats is 250~350 DEG C, and the time of the insulation is 20
~40min.
Preferably, in step 4, the pickling is specially：Ultrasonic 5~30min of pickling in pickle.
Preferably, the pickle includes each component of following content：10~20g/L of sodium hydroxide, sodium carbonate 40~
50g/L, 50~100g/L of sodium sulphate, solvent are deionized water.
Preferably, in step 4, polishing fluid used in the electrochemical polishing treatment is 200~250g/L of chromic anhydride, 80~
120ml/L additives；
Preferably, the additive includes：Hydrofluoric acid 62%, sulfuric acid 3%, nitric acid 35%.
Preferably, the temperature used in the electrochemical polishing treatment is room temperature, polishing time 20-30s.
Compared with prior art, the present invention has following beneficial effect：
(1) preparation method technique of the present invention is simple, using hot extrusion prepare the direct multi-pass cold rolling of middle tubing or
Cold drawing can be obtained by capillary tubes, and the degradable kirsite nerve trachea wall thickness for neurologic defect reparation prepared
Uniformly, surface non-oxidation and smooth.And in prepared by magnesium alloy nerve trachea, preparing capillary tubes using tubing among magnesium alloy must
Need aid in being heat-treated, i.e., using high temperature rolling and/or high temperature drawing, it is therefore an objective to caused by eliminating during magnesium alloy deformation plus
Work is hardened；If it uses room temperature rolling and/or room temperature drawing, will cause to make after multi-pass room temperature rolling and/or room temperature drawing
Standby capillary cracking.
(2) material that the present invention is used for the degradable kirsite nerve trachea of neurologic defect reparation is kirsite, due to it
Fusing point is relatively low and will not burn and easy to process, while alloy biodegradability is excellent, and biocompatibility is good, tube chamber support
Effect is good, and tube wall permeability with holes is good.
(3) mechanical property of porous, degradable kirsite nerve trachea, anti-microbial property, biocompatibility, corrosion resisting property etc.
Can be by adding beneficial to alloying element cu, Li, Mg, the one or more in Fe, RE etc. carry out conveniently regulating and controlling.For example, addition Cu can
To significantly improve the antibacterial effect of porous, degradable kirsite nerve trachea, addition Mg can significantly improve nerve trachea biofacies
Capacitive, addition alloy Li can significantly improve the mechanical property of nerve trachea.In addition, porous, degradable kirsite nerve trachea
Corrosion resistance can be by techniques such as composition, tube wall thickness, heat treatments come conveniently regulating and controlling, and present invention firstly provides using porous, degradable
The tissue-engineered bioartificial nerve graft repair system of kirsite nerve trachea structure bridges reparation neurologic defect.
(4) present invention is used for the even tube wall distribution certain amount of the degradable kirsite nerve trachea of neurologic defect reparation
Hole, the peripheral nerve for being advantageous to defect exchanges with the nutrition that tube wall outside is organized, while catheter wall distribution is a number of
Hole also acts as the effect of regulation and control degradation rate, is advantageously implemented the matching of nerve regneration required time and conduit degradation time.
Brief description of the drawings
The detailed description made by reading with reference to the following drawings to non-limiting example, further feature of the invention,
Objects and advantages will become more apparent upon：
Fig. 1 is the degradable kirsite nerve trachea structure chart of neurologic defect reparation of the invention.
Embodiment
With reference to specific embodiment, the present invention is described in detail.Following examples will be helpful to the technology of this area
Personnel further understand the present invention, but the invention is not limited in any way.It should be pointed out that the ordinary skill to this area
For personnel, without departing from the inventive concept of the premise, various modifications and improvements can be made.These belong to the present invention
Protection domain.
Embodiment 1
The present embodiment is related to a kind of degradable kirsite nerve trachea of neurologic defect reparation, and its structure is as shown in figure 1, long
It is 0.1mm tubular type to spend for 10mm, external diameter 2mm, wall thickness, and 4 row through holes, each column are provided with the tube wall of the nerve trachea
Through hole is along pipe axially equidistantly arrangement, and the through hole Heterogeneous Permutation of adjacent column, the quantity of each column through hole is 5, except conduit two
It is outer that end respectively has a pair of a diameter of 0.4mm macropore to be used to banding fixed nerve, and remaining aperture is 0.3mm.Porosity is
5%.
The present embodiment is related to preparation method of the foregoing neurologic defect reparation with degradable kirsite nerve trachea, the side
Method comprises the following steps：
Step 1, by the cylindrical Zn-Cu binary kirsite blank that external diameter is 20mm, centre processing diameter 7.8mm's is logical
Hole, extruded under the conditions of being 280 DEG C in temperature, obtain tubing among kirsite(external diameter × wall thickness)；
Step 2, by tubing among kirsite after the rolling of multi-pass normal temperature, it is 2mm to obtain external diameter, and wall thickness is 0.1mm hair
Tubule；
Step 3, capillary is subjected to annealing heat-treats under the conditions of temperature is 280 DEG C, is incubated 30min, laser cutting, beats
Hole, obtain multiholed catheter；
Step 4, by multiholed catheter in supersonic cleaning machine 5~30min of pickling, electrochemical polishing treatment is (at the polishing
The voltage of reason is 2~8V, and the time of polishing is 20~240s), room temperature is carried out, you can must be used for neurologic defect reparation can
Degraded kirsite nerve trachea.
The pickle includes each component of following content：Sodium hydroxide 10g/L, sodium carbonate 50g/L, sodium sulphate 100g/
L, solvent are deionized water.
Polishing fluid used in the electrochemical polishing treatment is chromic anhydride 250g/L, 80ml/L additive；The additive bag
Include：Hydrofluoric acid 62%, sulfuric acid 3%, nitric acid 35%.
Embodiment 2
The present embodiment is related to a kind of degradable kirsite nerve trachea of neurologic defect reparation, and its structure is as shown in figure 1, long
It is 4mm tubular type to spend for 50mm, wall thickness 0.15mm, external diameter, is provided with 8 row through holes on the tube wall of the nerve trachea, often
Row through hole is along pipe axially equidistantly arrangement, and the through hole Heterogeneous Permutation of adjacent column, the quantity of each column through hole is 50, except conduit
It is outer that both ends respectively have a pair of a diameter of 0.5mm macropore to be used to banding fixed nerve, and remaining aperture is 0.2mm.Porosity is
10%.
The present embodiment is related to preparation method of the foregoing neurologic defect reparation with degradable kirsite nerve trachea, the side
Method comprises the following steps：
Step 1, the cylindrical Zn-Cu-Fe ternarys kirsite blank that external diameter is 20mm, centre are processed diameter 7.8mm's
Through hole, extruded under the conditions of being 250 DEG C in temperature, obtain tubing among kirsite(external diameter × wall thickness)；
Step 2, by tubing among kirsite after multi-pass normal temperature drawing, it is 4mm to obtain external diameter, and wall thickness is 0.15mm hair
Tubule；
Step 3, capillary is subjected to annealing heat-treats under the conditions of temperature is 300 DEG C, is incubated 20min, laser cutting, beats
Hole, obtain multiholed catheter；
Step 4, by multiholed catheter in supersonic cleaning machine 5~30min of pickling, electrochemical polishing treatment is (at the polishing
The voltage of reason is 2~8V, and the time of polishing is 20~240s), room temperature is carried out, you can must be used for neurologic defect reparation can
Degraded kirsite nerve trachea.
The pickle includes each component of following content：Sodium hydroxide 20g/L, sodium carbonate 40g/L, sodium sulphate 80g/L,
Solvent is deionized water.
Polishing fluid used in the electrochemical polishing treatment is chromic anhydride 200g/L, 120ml/L additive；The additive bag
Include：Hydrofluoric acid 62%, sulfuric acid 3%, nitric acid 35%.
Embodiment 3
The present embodiment is related to a kind of degradable kirsite nerve trachea of neurologic defect reparation, and its structure is as shown in figure 1, long
It is 1mm tubular type to spend for 5mm, wall thickness 0.10mm, external diameter, and 4 row through holes, each column are provided with the tube wall of the nerve trachea
Through hole is along pipe axially equidistantly arrangement, and the through hole Heterogeneous Permutation of adjacent column, the quantity of each column through hole is 5, except conduit two
It is outer that end respectively has a pair of a diameter of 0.3mm macropore to be used to banding fixed nerve, and remaining aperture is 0.2mm.Porosity is
15%.
The present embodiment is related to preparation method of the foregoing neurologic defect reparation with degradable kirsite nerve trachea, shown side
Method comprises the following steps：
Step 1, by the cylindrical Zn-Li ternarys kirsite blank that external diameter is 30mm, centre processing diameter 7.8mm's is logical
Hole, extruded under the conditions of being 200 DEG C in temperature, obtain tubing among kirsite(external diameter × wall thickness)；
Step 2, by tubing among kirsite after the rolling of multi-pass normal temperature, normal temperature drawing, it is 1mm to obtain external diameter, and wall thickness is
0.10mm capillary；
Step 3, capillary is subjected to annealing heat-treats under the conditions of temperature is 300 DEG C, is incubated 25min, laser cutting, beats
Hole, obtain multiholed catheter；
Step 4, by multiholed catheter in supersonic cleaning machine 5~30min of pickling, electrochemical polishing treatment is (at the polishing
The voltage of reason is 2~8V, and the time of polishing is 20~240s), room temperature is carried out, you can must be used for neurologic defect reparation can
Degraded kirsite nerve trachea.
The pickle includes each component of following content：Sodium hydroxide 15g/L, sodium carbonate 45g/L, sodium sulphate 50g/L,
Solvent is deionized water.
Polishing fluid used in the electrochemical polishing treatment is chromic anhydride 220g/L, 100ml/L additive；The additive bag
Include：Hydrofluoric acid 62%, sulfuric acid 3%, nitric acid 35%.
Implementation result：Porous, degradable kirsite nerve trachea plasticity is preferable made from embodiment 1~3, and elongation percentage is more than
10%, some alloys are even more than 70%, and porous, degradable kirsite nerve trachea made from embodiment 1~3 is implanted into respectively
To at the Sciatic of adult SD rats.It is refreshing at gross examination of skeletal muscle previous anastomotic in nerve trachea implantation rat body after one month
It is good through regenerating, cicatricial tissue and inflammatory reaction are around had no, has no bubble formation, although conduit is not degradable, is led
Pipe softens.Neural axon regeneration is good, and neurologic defect is repaired substantially.There are the nerve fiber of regeneration, nerve fiber in conduit cavity
Distal end, repair deficiency are proximally grown into by previous anastomotic.
Comparative example 1
This comparative example provides a kind of neurologic defect reparation degradable kirsite nerve trachea, its structure, preparation method
And embodiment 1 is identical, the difference is that only：The kirsite that the present invention uses for：Zn-Mg.The alloy is in multi-pass room temperature
During rolling, the phenomenon of generation tubing cracking is serious, and capillary tubes can not be molded well, and alloy plasticity is poor, be prolonged
Rate is stretched less than 10%.
Comparative example 2
This comparative example provides a kind of neurologic defect reparation degradable kirsite nerve trachea, its structure, preparation method
And embodiment 1 is identical, the difference is that only：The pickle that the present invention uses for：Sodium hydroxide 30g/L, sodium carbonate 30g/
L, 50~100g/L of sodium sulphate, solvent are deionized water.
Using the pickle composition of this comparative example, the easy oxidizing blackening in nerve trachea surface during pickling, it is impossible to
The purpose of pickling is realized, while during pickling, local corrosion destruction easily occurs in conduit.
Comparative example 3
This comparative example provides a kind of neurologic defect reparation degradable kirsite nerve trachea, its structure, preparation method
And embodiment 1 is identical, the difference is that only：The present invention is used in polishing fluid, and the additive includes volumes below percentage
The each component of ratio：Hydrofluoric acid 65%, nitric acid 35%.
After the additive component of this comparative example, nerve trachea surface oxidation during polishing blacks, it is impossible to real
The purpose now polished.
Concrete application approach of the present invention is a lot, and described above is only the preferred embodiment of the present invention.More than it should be pointed out that
Embodiment is merely to illustrate the present invention, and the protection domain being not intended to limit the invention.For the common skill of the art
For art personnel, under the premise without departing from the principles of the invention, some improvement can also be made, these improvement also should be regarded as this hair
Bright protection domain.
Claims (10)
- A kind of 1. degradable kirsite nerve trachea of neurologic defect reparation, it is characterised in that the nerve trachea is tubular type, Multiple row through hole is provided with the nerve trachea tube wall, each column through hole is wrong along pipe axially equidistantly arrangement, the through hole of adjacent column Position arrangement；There is a pair of a diameter of 0.3-0.5mm macropore at the both ends of the nerve trachea respectively.
- 2. the degradable kirsite nerve trachea of neurologic defect reparation as claimed in claim 1, it is characterised in that the zinc closes Gold is that Zn-Cu, Zn-Li bianry alloys, or at least one of Zn-Cu-Fe, Zn-Cu-Mg, Zn-Cu-RE ternary alloy three-partalloy close Gold.
- 3. the degradable kirsite nerve trachea of neurologic defect reparation as claimed in claim 2, it is characterised in that the zinc closes Jin Zhong, Zn content are more than 90wt%.
- 4. the degradable kirsite nerve trachea of neurologic defect reparation as claimed in claim 1, it is characterised in that the nerve The length of conduit is 5~50mm, and the thickness of the nerve trachea is 0.05~0.2mm, the aperture of the through hole for 0.05~ 0.5mm, the porosity of the nerve trachea is 5~25%.
- A kind of 5. neurologic defect reparation as described in claim any one of 1-4 preparation side of degradable kirsite nerve trachea Method, it is characterised in that methods described comprises the following steps：Step 1, through hole will be processed among cylindrical kirsite blank, hot extrusion is carried out to it and obtains seamless kirsite intervalve Material；Step 2, by tubing among kirsite after multi-pass room temperature rolling and/or room temperature drawing, obtain capillary；Step 3, capillary is subjected to annealing heat-treats, be cut by laser, punching, obtain multiholed catheter；Step 4, the pickling in supersonic cleaning machine, electrochemical polishing treatment by multiholed catheter, you can neurologic defect reparation must be used for Degradable kirsite nerve trachea.
- 6. the neurologic defect reparation as claimed in claim 5 preparation method of degradable kirsite nerve trachea, its feature exist In in step 1, the extrusion temperature is 150~280 DEG C.
- 7. the neurologic defect reparation as claimed in claim 5 preparation method of degradable kirsite nerve trachea, its feature exist In in step 3, described annealing heat-treats temperature is 250~350 DEG C, and the time of the insulation is 20~40min.
- 8. the neurologic defect reparation as claimed in claim 5 preparation method of degradable kirsite nerve trachea, its feature exist In the pickle includes each component of following content：10~20g/L of sodium hydroxide, 40~50g/L of sodium carbonate, sodium sulphate 50 ~100g/L, solvent are deionized water.
- 9. the neurologic defect reparation as claimed in claim 5 preparation method of degradable kirsite nerve trachea, its feature exist In in step 4, the polishing fluid used in the electrochemical polishing treatment includes chromic anhydride 200~250g/L, 80~120ml/L addition Agent.
- 10. the neurologic defect reparation as claimed in claim 9 preparation method of degradable kirsite nerve trachea, its feature exist In the additive includes each component of volumes below percentage：Hydrofluoric acid 62%, sulfuric acid 3%, nitric acid 35%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610756193.2A CN107779672B (en) | 2016-08-29 | 2016-08-29 | Neurologic defect reparation degradable kirsite nerve trachea and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610756193.2A CN107779672B (en) | 2016-08-29 | 2016-08-29 | Neurologic defect reparation degradable kirsite nerve trachea and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107779672A true CN107779672A (en) | 2018-03-09 |
| CN107779672B CN107779672B (en) | 2019-09-17 |
Family
ID=61440210
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610756193.2A Active CN107779672B (en) | 2016-08-29 | 2016-08-29 | Neurologic defect reparation degradable kirsite nerve trachea and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107779672B (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110584829A (en) * | 2019-09-17 | 2019-12-20 | 深圳兰度生物材料有限公司 | Nerve repair catheter |
| CN111037016A (en) * | 2019-12-06 | 2020-04-21 | 西安铂力特增材技术股份有限公司 | Electrolyte for electrolytic machining of nickel-based high-temperature alloy component and preparation method thereof |
| CN112756802A (en) * | 2020-12-24 | 2021-05-07 | 江苏腾奇电力设备科技有限公司 | Punching and cutting process of oil collecting pipe of finned radiator for transformer |
| CN114850805A (en) * | 2022-06-07 | 2022-08-05 | 上海交通大学 | Magnesium-zinc alloy biliary tract stent and preparation method thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103394545A (en) * | 2013-07-30 | 2013-11-20 | 上海交通大学 | Precise machining method for capillary tube for biodegradable magnesium alloy intravascular stent |
| CN103598927A (en) * | 2013-10-17 | 2014-02-26 | 上海交通大学 | Degradable magnesium alloy nerve conduit for nerve defect repair and preparation method of nerve conduit |
| CN104258458A (en) * | 2014-09-10 | 2015-01-07 | 上海交通大学 | Degradable open-cell porous zinc/zinc alloy biomaterial and preparation method thereof |
| CN104328312A (en) * | 2014-10-20 | 2015-02-04 | 东北大学 | Medical biodegradable zinc alloy and preparation method thereof |
| CN104651664A (en) * | 2015-03-13 | 2015-05-27 | 周功耀 | Corrosion-resistant and high-strength and toughness Zn-Fe-RE-based zinc alloy capable of being degraded in human body and application of corrosion-resistant and high-strength and toughness Zn-Fe-Li-based zinc alloy |
-
2016
- 2016-08-29 CN CN201610756193.2A patent/CN107779672B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103394545A (en) * | 2013-07-30 | 2013-11-20 | 上海交通大学 | Precise machining method for capillary tube for biodegradable magnesium alloy intravascular stent |
| CN103598927A (en) * | 2013-10-17 | 2014-02-26 | 上海交通大学 | Degradable magnesium alloy nerve conduit for nerve defect repair and preparation method of nerve conduit |
| CN104258458A (en) * | 2014-09-10 | 2015-01-07 | 上海交通大学 | Degradable open-cell porous zinc/zinc alloy biomaterial and preparation method thereof |
| CN104328312A (en) * | 2014-10-20 | 2015-02-04 | 东北大学 | Medical biodegradable zinc alloy and preparation method thereof |
| CN104651664A (en) * | 2015-03-13 | 2015-05-27 | 周功耀 | Corrosion-resistant and high-strength and toughness Zn-Fe-RE-based zinc alloy capable of being degraded in human body and application of corrosion-resistant and high-strength and toughness Zn-Fe-Li-based zinc alloy |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110584829A (en) * | 2019-09-17 | 2019-12-20 | 深圳兰度生物材料有限公司 | Nerve repair catheter |
| CN111037016A (en) * | 2019-12-06 | 2020-04-21 | 西安铂力特增材技术股份有限公司 | Electrolyte for electrolytic machining of nickel-based high-temperature alloy component and preparation method thereof |
| CN112756802A (en) * | 2020-12-24 | 2021-05-07 | 江苏腾奇电力设备科技有限公司 | Punching and cutting process of oil collecting pipe of finned radiator for transformer |
| CN114850805A (en) * | 2022-06-07 | 2022-08-05 | 上海交通大学 | Magnesium-zinc alloy biliary tract stent and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN107779672B (en) | 2019-09-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107779672B (en) | Neurologic defect reparation degradable kirsite nerve trachea and preparation method thereof | |
| WO2015188403A1 (en) | Biodegradable magnesium alloy nerve conduit for repairing nerve defects and preparation method thereof | |
| CN101829364B (en) | Method for preparing biodegradable magnesium alloy intravascular stent | |
| CN101461964B (en) | Bioactivity surface modification method of biological medical degradable magnesium alloy | |
| CN101015711B (en) | Medical implantation material capable of by degraded by body fluid and its preparing process | |
| CN102895706B (en) | Biomedical anti-corrosion porous compound material and preparation method thereof | |
| EP2189170A1 (en) | Method for manufacturing an anti-corrosive coating on an implant made from a bio-corrodible magnesium alloy and the implant resulting from the method | |
| CN101709496B (en) | Micro-arc oxidation-electrodeposition preparation method of magnesium-based bioactive coating | |
| CN108297500B (en) | Preparation method of degradable metal composite plate for craniomaxillofacial bone repair | |
| DE102006060501A1 (en) | Forming corrosion-inhibiting anodized coating on bio-corrodible magnesium alloy implant, treats implant in aqueous or alcoholic solution containing specified ion concentration | |
| CN106693069B (en) | Medical porous titanium tantalum artificial bone, preparation method of joint prosthesis and products thereof | |
| EP2545945B1 (en) | Implant, component set, method for manufacturing an implant and/or a component set and device for manufacturing an implant and/or a component set | |
| CN114159197B (en) | Degradable biomedical magnesium alloy drug-eluting intravascular stent and preparation method thereof | |
| CN112410866B (en) | Electrochemical polishing solution and polishing method for nickel-titanium alloy | |
| CN111676390B (en) | Zn-Ga alloy, preparation method and application thereof | |
| CN102747405A (en) | Preparation method of composite ceramic coating for improving bioactivity of medical magnesium alloy | |
| CN103526262A (en) | Method for performing surface modification on tantalum and tantalum alloy and electrolyte used in method | |
| CN111407923A (en) | Drug release controlled magnesium or magnesium alloy bionic bone and preparation method thereof | |
| CN107998445A (en) | A kind of surface modification porous tantalum biomaterial and preparation method thereof | |
| CN105887179A (en) | Electrolytic polishing liquid of tungsten alloy or molybdenum alloy and electrolytic polishing method | |
| TWI526202B (en) | Methods of processing vascular stents | |
| Shi et al. | Advances in amelioration of plasma electrolytic oxidation coatings on biodegradable magnesium and alloys | |
| CN103290455A (en) | Titanium micro/nanometer double-structured dioxide thin film with high biological activity and preparation method thereof | |
| CN115444971B (en) | Comprehensive processing method of biodegradable porous magnesium alloy bracket for repairing bone defect | |
| CN114392398A (en) | Biodegradable medical metal magnesium patch and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |