CN108297500B - Preparation method of degradable metal composite plate for craniomaxillofacial bone repair - Google Patents

Preparation method of degradable metal composite plate for craniomaxillofacial bone repair Download PDF

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CN108297500B
CN108297500B CN201810207870.4A CN201810207870A CN108297500B CN 108297500 B CN108297500 B CN 108297500B CN 201810207870 A CN201810207870 A CN 201810207870A CN 108297500 B CN108297500 B CN 108297500B
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zinc
plate
magnesium
iron
based metal
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CN108297500A (en
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王昌
于振涛
余森
麻西群
赵曦
程军
刘汉源
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Northwest Institute for Non Ferrous Metal Research
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    • B32B15/00—Layered products comprising a layer of metal
    • B32B15/01—Layered products comprising a layer of metal all layers being exclusively metallic
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B21—MECHANICAL METAL-WORKING WITHOUT ESSENTIALLY REMOVING MATERIAL; PUNCHING METAL
    • B21B—ROLLING OF METAL
    • B21B1/00—Metal-rolling methods or mills for making semi-finished products of solid or profiled cross-section; Sequence of operations in milling trains; Layout of rolling-mill plant, e.g. grouping of stands; Succession of passes or of sectional pass alternations
    • B21B1/38—Metal-rolling methods or mills for making semi-finished products of solid or profiled cross-section; Sequence of operations in milling trains; Layout of rolling-mill plant, e.g. grouping of stands; Succession of passes or of sectional pass alternations for rolling sheets of limited length, e.g. folded sheets, superimposed sheets, pack rolling
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B21—MECHANICAL METAL-WORKING WITHOUT ESSENTIALLY REMOVING MATERIAL; PUNCHING METAL
    • B21B—ROLLING OF METAL
    • B21B47/00—Auxiliary arrangements, devices or methods in connection with rolling of multi-layer sheets of metal
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B15/00—Layered products comprising a layer of metal
    • B32B15/01—Layered products comprising a layer of metal all layers being exclusively metallic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B7/00—Layered products characterised by the relation between layers; Layered products characterised by the relative orientation of features between layers, or by the relative values of a measurable parameter between layers, i.e. products comprising layers having different physical, chemical or physicochemical properties; Layered products characterised by the interconnection of layers
    • B32B7/04—Interconnection of layers
    • B32B7/08—Interconnection of layers by mechanical means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B21—MECHANICAL METAL-WORKING WITHOUT ESSENTIALLY REMOVING MATERIAL; PUNCHING METAL
    • B21B—ROLLING OF METAL
    • B21B1/00—Metal-rolling methods or mills for making semi-finished products of solid or profiled cross-section; Sequence of operations in milling trains; Layout of rolling-mill plant, e.g. grouping of stands; Succession of passes or of sectional pass alternations
    • B21B1/38—Metal-rolling methods or mills for making semi-finished products of solid or profiled cross-section; Sequence of operations in milling trains; Layout of rolling-mill plant, e.g. grouping of stands; Succession of passes or of sectional pass alternations for rolling sheets of limited length, e.g. folded sheets, superimposed sheets, pack rolling
    • B21B2001/386—Plates
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    • B32B2307/70—Other properties
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    • B32—LAYERED PRODUCTS
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    • B32B2307/00—Properties of the layers or laminate
    • B32B2307/70—Other properties
    • B32B2307/716—Degradable
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
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Abstract

The degradable craniomaxillofacial bone repairing metal composite plate with the structure can solve the problems of poor biocompatibility and nondegradable requirement for secondary operation taking of a clinical craniomaxillofacial bone repairing material, can adjust the degradation time of the metal composite plate by controlling the thickness ratio of the magnesium-based or iron-based metal plate to the zinc-based metal plate, enables the degradation speed to better correspond to the human body recovery speed, and promotes the human body recovery speed. According to the invention, the degradable craniomaxillofacial bone repair material is formed by compounding the zinc-based metal plate on the surface of the magnesium-based or iron-based metal plate through the preparation method of cladding and rolling, the process treatment method is simple and easy to control, and the manufacturing cost is low.

Description

Preparation method of degradable metal composite plate for craniomaxillofacial bone repair
Technical Field
The invention belongs to the technical field of biomedical materials, and particularly relates to a preparation method of a degradable metal composite plate for craniomaxillofacial bone repair.
Background
At present, craniomaxillofacial repair materials used in clinic are mainly made of metal materials or high polymer materials. The majority of the used metal materials are titanium-based non-degradable metals, and the high-molecular craniomaxillofacial repair material is polyether-ether-ketone or polylactic acid generally. At present, the two types of materials can basically meet the clinical requirements, but have certain limitations and potential problems. For example, for the repair of craniomaxillofacial surfaces of juveniles, the bones of the juveniles are not completely developed and matured, and the development of the later-stage bones is hindered by using non-degradable materials; degradable polylactic acid is used as a craniomaxillofacial repair material, and as lactic acid monomers can be released in the degradation process, the local part of body tissues presents an acidic environment, so that tissue effusion and inflammatory reaction occur, the treatment effect is influenced, and even the internal plants need to be taken out in severe cases. Therefore, at present, no micro craniomaxillofacial bone fracture plate or otter board which has excellent biocompatibility, can guide the regeneration and healing of defective bones, can be completely degraded or absorbed and has controllable degradation time is provided in the field of craniomaxillofacial bone repair to meet the clinical requirements. It is reported that magnesium ions released by the degradation of magnesium-based metal can promote the growth of cells of new bones, and zinc ions released by the degradation of zinc-based metal have an antibacterial effect. However, magnesium-based metals are degraded in human bodies at a high speed, and usually need to be subjected to surface treatment to prolong the degradation time, while zinc-based metals are degraded in human bodies at a moderate speed, and iron-based metals are degraded at a low speed. And thirdly, the degradation time of the metal which is used as the degradable material is difficult to regulate. There is therefore a need for improvements.
Disclosure of Invention
The technical problems solved by the invention are as follows: the degradable cranio-maxillofacial bone repair metal composite plate prepared by the invention can not only solve the problems of poor biocompatibility and nondegradable requirement for secondary operation and removal of a clinical cranio-maxillofacial bone repair material, but also can adjust the degradation time of the metal composite plate by controlling the thickness ratio of the magnesium-based or iron-based metal plate to the zinc-based metal plate, so that the degradation speed can better correspond to the human body recovery speed, and the human body recovery speed is promoted. The invention is manufactured by a preparation method of cladding and rolling, and the process treatment method is simple and easy to control and has low manufacturing cost.
The technical scheme adopted by the invention is as follows: the preparation method of the degradable metal composite plate for craniomaxillofacial bone repair comprises a magnesium-based or iron-based metal plate and two zinc-based metal plates, wherein the two zinc-based metal plates are respectively compounded on two surfaces of the magnesium-based or iron-based metal plate to form a zinc-magnesium-zinc three-layer metal composite plate or a zinc-iron-zinc three-layer metal composite plate. The zinc-magnesium-zinc three-layer metal composite plate or the zinc-iron-zinc three-layer metal composite plate is manufactured by adopting a zinc-based metal plate to coat the surface of the magnesium-based or iron-based metal plate and then performing lap rolling, and specifically comprises the following steps:
the method comprises the following steps: before rolling, a plurality of grooves or tetrahedral press pits are uniformly and densely manufactured on two surfaces of a magnesium-based or iron-based metal plate, two layers of zinc-based metal plates are respectively coated on the two surfaces of the magnesium-based or iron-based metal plate with the grooves or the tetrahedral press pits, and then the rolled front end surfaces of the zinc-based metal plate and the magnesium-based or iron-based metal plate coated together are welded together;
step two: performing lap rolling on the zinc-based metal plate and the magnesium-based or iron-based metal plate which are covered together in the step one to form a zinc-magnesium-zinc three-layer metal composite plate or a zinc-iron-zinc three-layer metal composite plate, wherein the rolling heating temperature is 200-300 ℃, the rolling deformation of a single pass is controlled to be 10-30%, and the total rolling deformation is not less than 60%;
step three: and leveling and trimming the three-layer metal composite plate manufactured by the pack rolling in the step two.
The magnesium-based or iron-based metal plate is made of pure magnesium or magnesium alloy or pure iron or iron alloy, and the zinc-based metal plate is made of pure zinc or zinc alloy.
The thickness of the metal composite plate is 1-4 mm, wherein the thickness of a magnesium-based or iron-based metal plate in the metal composite plate is 0.8-3 mm, and the thickness of a single-layer zinc-based metal plate in the metal composite plate is 0.1-1 mm; the thickness ratio of the magnesium-based or iron-based metal plate to the zinc-based metal plate is controlled by the total thickness of the metal composite plate, so that the degradation time of the metal composite plate is adjusted.
In the first step, the depth of the grooves or the tetrahedral pressing pits on the surface of the magnesium-based or iron-based metal plate is less than one half of the thickness of the zinc-based metal plate before the pack rolling.
Compared with the prior art, the invention has the advantages that:
1. the scheme adopts the magnesium-based or iron-based metal plate and the zinc-based metal plate to manufacture the composite metal plate, the composite metal plate can be completely degraded or absorbed, the two metal materials do not contain metal elements with toxic and side effects on human bodies, such as Al, Ce, La and the like, the composite metal plate has excellent biocompatibility and the characteristics of guiding the regeneration of defective bones and resisting bacteria, the limitations that the clinical cranio-maxillofacial bone repair material has poor biocompatibility and is not degradable and needs to be taken out by secondary operation can be solved, and the pain of patients caused by the secondary operation can be avoided;
2. according to the scheme, two layers of zinc-based metal plates are respectively compounded on two surfaces of a magnesium-based or iron-based metal plate to form the zinc-magnesium-zinc three-layer metal composite plate or the zinc-iron-zinc three-layer metal composite plate, different characteristics of magnesium or iron-based metal and zinc-based metal are utilized in the using process, the zinc-based metal compounded on the outside is degraded firstly, the generated antibacterial effect can effectively inhibit the problems of infection and inflammation easily generated in the early stage of implantation, the degradation rate in the early stage is moderate, the magnesium or iron-based metal plate coated inside is more beneficial to maintaining mechanical support, the magnesium-based metal starts to degrade in the later stage, the bone growth can be induced, and the magnesium-based metal plate can be degraded. If long-time degradation is needed, the thickness of the outer zinc-based metal plate can be increased, and iron-based metal can be used for replacing magnesium-based metal to be used as the inner metal to further prolong the degradation time. The degradable cranio-maxillofacial bone repair metal composite plate with the structure solves the problems that the cranio-maxillofacial bone repair material is not degraded, the single magnesium-based metal is degraded too fast or the single iron-based metal is degraded slowly, and the degradation speed can better correspond to the human body recovery speed, so that the human body recovery speed is promoted;
3. according to the scheme, the degradable craniomaxillofacial bone repair material is formed by compounding the zinc-based metal plate on the surface of the magnesium-based or iron-based metal plate through a coating and rolling preparation method, the process treatment method is simple, the parameters of the formed metal composite plate are easy to control, and the manufacturing cost is low;
4. according to the scheme, the thickness ratio of the magnesium-based or iron-based metal plate to the zinc-based metal plate is controlled through the total thickness of the metal composite plate, so that the degradation time of the metal composite plate is adjusted, the metal composite plates with different thickness ratios have different degradation times, the degradation requirements of different constitutions of adults, minors and the old can be met, and the metal composite plate has wide adaptability.
Drawings
FIG. 1 is a schematic structural diagram of the present invention.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
The technical scheme of the invention is described in detail in the following with reference to the accompanying drawings.
The preparation method of the degradable metal composite plate for craniomaxillofacial bone repair comprises a layer of magnesium-based or iron-based metal plate 1 and two layers of zinc-based metal plates 2, wherein the two layers of zinc-based metal plates 2 are respectively compounded on two surfaces of the magnesium-based or iron-based metal plate 1 to form a zinc-magnesium-zinc three-layer metal composite plate or a zinc-iron-zinc three-layer metal composite plate as shown in figure 1. The magnesium-based or iron-based metal plate 1 is made of pure magnesium or magnesium alloy or pure iron or iron alloy, and the zinc-based metal plate 2 is made of pure zinc or zinc alloy. The composite metal plate can be completely degraded or absorbed, the two metal materials do not contain metal elements such as Al, Ce, La and the like which have toxic and side effects on human bodies, the composite metal plate has excellent biocompatibility and the characteristics of guiding the regeneration of defective bones and resisting bacteria, the limitations that clinical craniomaxillofacial bone repair materials are poor in biocompatibility and can not be degraded and need to be taken out in a secondary operation can be solved, and the pain of patients caused by the secondary operation can be avoided.
Preferably, the thickness of the metal composite plate is 1-4 mm, wherein the thickness of a magnesium-based or iron-based metal plate 1 in the metal composite plate is 0.8-3 mm, and the thickness of a single-layer zinc-based metal plate 2 in the metal composite plate is 0.1-1 mm; the thickness ratio of the magnesium-based or iron-based metal plate 1 to the zinc-based metal plate 2 is controlled by the total thickness of the metal composite plate, so that the degradation time of the metal composite plate is adjusted, the metal composite plates with different thickness ratios have different degradation times, the degradation requirements of adults, minors and the old on different constitutions can be met, and the metal composite plate has wide adaptability.
The zinc-magnesium-zinc three-layer metal composite plate or the zinc-iron-zinc three-layer metal composite plate is manufactured by adopting the zinc-based metal plate 2 to coat the surface of the magnesium-based or iron-based metal plate 1 and then performing lap rolling, the process treatment method is simple, the parameters of the formed metal composite plate are easy to control, and the manufacturing cost is low. The method specifically comprises the following steps:
the method comprises the following steps: before rolling, a plurality of grooves or tetrahedral indentations are uniformly and densely manufactured on two surfaces of a magnesium-based or iron-based metal plate 1, two layers of zinc-based metal plates 2 are respectively coated on two surfaces of the magnesium-based or iron-based metal plate 1 with the grooves or the tetrahedral indentations, and then the zinc-based metal plates 2 coated together and the rolling front end faces of the magnesium-based or iron-based metal plate 1 are welded together; wherein the depth of the grooves or the tetrahedral pressing pits is less than half of the thickness of the zinc-based metal sheet 2 before the pack rolling.
Step two: the zinc-based metal plate 2 and the magnesium-based or iron-based metal plate 1 which are coated together in the step one are subjected to stack rolling to form a zinc-magnesium-zinc three-layer metal composite plate or a zinc-iron-zinc three-layer metal composite plate, wherein the rolling heating temperature is 200-300 ℃, the rolling deformation of a single pass is controlled to be 10-30%, and the total rolling deformation is not less than 60%;
step three: and leveling and trimming the three-layer metal composite plate manufactured by the pack rolling in the step two.
Four different embodiments of the invention are listed below:
the first embodiment is as follows:
taking a magnesium-zinc-zirconium alloy plate with the length, width and thickness of 150mm, 100mm and 3mm respectively, taking a zinc-magnesium-copper alloy plate with the thickness of 0.4mm, pressing tetrahedral press pits with the depth of 0.15mm on two surfaces of the magnesium-zinc-zirconium alloy plate, coating the magnesium-zinc-zirconium alloy plate by using a cleaned zinc-magnesium-copper alloy plate with the thickness of 0.4mm, and welding the zinc-magnesium-copper alloy plate coated with the end surface before rolling and the magnesium-zinc-zirconium alloy plate together. Heating the clad plate to 250 ℃, controlling the rolling deformation of a single pass to be 10-30%, and controlling the final plate thickness to be 1.0mm by 6 passes of hot pack rolling, so that the plate thickness of the magnesium-zinc-zirconium alloy is about 0.8mm, the plate thickness of the single-layer zinc-magnesium-copper alloy is about 0.1mm, and the thickness ratio of the magnesium-based metal plate to the zinc-based metal plate in the composite plate is 8. The manufactured plate can be used for skull restoration after being leveled and trimmed.
Example two:
taking a magnesium-zinc-calcium alloy plate with the length, width and thickness of 80mm, 40mm and 7.5mm respectively, taking a pure zinc plate with the thickness of 0.5mm, pressing tetrahedral press pits with the depth of 0.2mm on two surfaces of the magnesium-zinc-zirconium alloy plate, coating the magnesium-zinc-calcium alloy plate by using a clean pure zinc plate with the thickness of 0.5mm, and welding the pure zinc plate coated with the end surface before rolling and the magnesium-zinc-calcium alloy plate together. Heating the clad plate to 250 ℃, controlling the rolling deformation of a single pass to be 10-30%, and controlling the final plate thickness to be 3.4mm by 5 passes of hot pack rolling, so that the plate thickness of the magnesium-zinc-calcium alloy is about 3mm, the plate thickness of a single-layer pure zinc plate is about 0.2mm, and the thickness ratio of the magnesium-based metal plate to the zinc-based metal plate in the composite plate is 15. The prepared plate can be used for repairing the jaw after being leveled and trimmed.
Example three:
taking a pure magnesium plate with the length, width and thickness of 100mm, 50mm and 5mm respectively, taking a zinc-copper alloy plate with the thickness of 2.5mm, pressing tetrahedral press pits with the depth of 1mm on two sides of the pure magnesium plate, coating the pure magnesium plate with a cleaned zinc-copper alloy plate with the thickness of 2.5mm, and welding the zinc-copper alloy plate coated on the end surface before rolling with the pure magnesium plate. Heating the cladding plate to 200 ℃, controlling the rolling deformation of a single pass to be 10-30%, and controlling the final plate thickness to be 4mm through 5 passes of hot pack rolling, so that the thickness of the pure magnesium plate is about 2mm, the thickness of the zinc-copper alloy plate is about 1mm, and the thickness ratio of the magnesium-based metal plate to the zinc-based metal plate in the composite plate is 2. The prepared plate can be used for repairing the jaw after being leveled and trimmed.
Example four:
taking a pure iron plate with the length, width and thickness of 120mm, 80mm and 5mm respectively, taking a zinc-magnesium-copper alloy plate with the thickness of 2mm, pressing tetrahedral pressing pits with the depth of 0.8mm on two surfaces of the pure iron plate, coating the pure iron plate with a cleaned zinc-magnesium-copper alloy plate with the thickness of 2mm, and welding the zinc-magnesium-copper alloy plate coated on the end surface before rolling and the pure iron plate together. Heating the cladding plate to 280 ℃, controlling the rolling deformation of a single pass to be 10-30%, and controlling the final plate thickness to be 3.6mm by 5 passes of hot pack rolling, so that the thickness of the pure iron plate is about 2mm, the thickness of the zinc-magnesium-copper alloy plate is about 0.8mm, and the thickness ratio of the iron-based metal plate to the zinc-based metal plate in the composite plate is 2.5. The prepared plate can be used for repairing the jaw after being leveled and trimmed.
According to the invention, two zinc-based metal plates 2 are respectively compounded on two surfaces of a magnesium-based or iron-based metal plate 1 to form a zinc-magnesium-zinc three-layer metal composite plate or a zinc-iron-zinc three-layer metal composite plate, different characteristics of magnesium or iron-based metal and zinc-based metal are utilized in the using process, the zinc-based metal compounded outside is degraded firstly, and the generated antibacterial action can effectively inhibit the problems of infection and inflammation easily generated in the early stage of implantation, and the degradation rate in the early stage is moderate, so that the magnesium-based metal plate coated inside is more beneficial to maintaining mechanical support, the magnesium-based metal starts to degrade in the later stage, the bone growth can be induced, and the magnesium-based metal plate can be rapidly degraded. If long-time degradation is needed, the thickness of the outer zinc-based metal plate can be increased, and iron-based metal can be used for replacing magnesium-based metal to be used as the inner metal to further prolong the degradation time. The degradable cranio-maxillofacial bone repairing metal composite plate with the structure solves the problems that the cranio-maxillofacial bone repairing material is not degraded, single magnesium-based metal is degraded too fast or single iron-based metal is degraded slowly, and the degradation speed of the degradable cranio-maxillofacial bone repairing metal composite plate can better correspond to the human body recovery speed, so that the human body recovery speed is accelerated.
The above-mentioned embodiments are merely preferred embodiments of the present invention, which are not intended to limit the scope of the present invention, and therefore, all equivalent changes made by the contents of the claims of the present invention should be included in the claims of the present invention.

Claims (4)

1. The preparation method of the degradable metal composite plate for craniomaxillofacial bone repair comprises a layer of magnesium-based or iron-based metal plate (1) and two layers of zinc-based metal plates (2), wherein the two layers of zinc-based metal plates (2) are respectively compounded on two surfaces of the magnesium-based or iron-based metal plate (1) to form a zinc-magnesium-zinc three-layer metal composite plate or a zinc-iron-zinc three-layer metal composite plate, and is characterized in that: the zinc-magnesium-zinc three-layer metal composite plate or the zinc-iron-zinc three-layer metal composite plate is manufactured by adopting a zinc-based metal plate (2) to cover the surface of a magnesium-based or iron-based metal plate (1) and then carrying out lap rolling, and specifically comprises the following steps:
the method comprises the following steps: before rolling, a plurality of grooves or tetrahedral press pits are uniformly and densely manufactured on two surfaces of a magnesium-based or iron-based metal plate (1), two layers of zinc-based metal plates (2) are respectively coated on two surfaces of the magnesium-based or iron-based metal plate (1) with the grooves or the tetrahedral press pits on the surface, and then the zinc-based metal plates (2) and the rolled front end surfaces of the magnesium-based or iron-based metal plate (1) which are coated together are welded together;
step two: the zinc-based metal plate (2) and the magnesium-based or iron-based metal plate (1) which are coated together in the step one are subjected to stack rolling to form a zinc-magnesium-zinc three-layer metal composite plate or a zinc-iron-zinc three-layer metal composite plate, wherein the rolling heating temperature is 200-300 ℃, the rolling deformation of a single pass is controlled to be 10-30%, and the total rolling deformation is not less than 60%;
step three: and leveling and trimming the three-layer metal composite plate manufactured by the pack rolling in the step two.
2. The method for preparing the degradable metal composite plate for craniomaxillofacial bone repair according to claim 1, wherein the method comprises the following steps: the magnesium-based or iron-based metal plate (1) is made of pure magnesium or magnesium alloy or pure iron or iron alloy, and the zinc-based metal plate (2) is made of pure zinc or zinc alloy.
3. The method for preparing the degradable metal composite plate for craniomaxillofacial bone repair according to claim 1, wherein the method comprises the following steps: the thickness of the metal composite plate is 1-4 mm, wherein the thickness of a magnesium-based or iron-based metal plate (1) in the metal composite plate is 0.8-3 mm, and the thickness of a single-layer zinc-based metal plate (2) in the metal composite plate is 0.1-1 mm; the thickness ratio of the magnesium-based or iron-based metal plate (1) to the zinc-based metal plate (2) is controlled by the total thickness of the metal composite plate, so that the degradation time of the metal composite plate is adjusted.
4. The method for preparing the degradable metal composite plate for craniomaxillofacial bone repair according to claim 1, wherein the method comprises the following steps: in the first step, the depth of the grooves or the tetrahedral pressing pits on the surface of the magnesium-based or iron-based metal plate (1) is less than one half of the thickness of the zinc-based metal plate (2) before the pack rolling.
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