CN107773780A - A kind of poly- trehalose material and preparation method thereof - Google Patents
A kind of poly- trehalose material and preparation method thereof Download PDFInfo
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- CN107773780A CN107773780A CN201610715634.4A CN201610715634A CN107773780A CN 107773780 A CN107773780 A CN 107773780A CN 201610715634 A CN201610715634 A CN 201610715634A CN 107773780 A CN107773780 A CN 107773780A
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- trehalose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
- C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
- C08J3/075—Macromolecular gels
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2305/00—Characterised by the use of polysaccharides or of their derivatives not provided for in groups C08J2301/00 or C08J2303/00
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Dispersion Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Polymers & Plastics (AREA)
- Medicinal Chemistry (AREA)
- Materials For Medical Uses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A kind of poly- trehalose material, mainly reach 70% by poly- trehalose hydrogel combination water content.The use gradient water bath Method of the invention, by the way of positive and negative gradient temperature, and hormone freezing mode, poly- marine alga sugar chain is rebuild to interrupt, establishes gel rubber material.This method is pollution-free, simple possible, easy to operate, is adapted to extensive sound field.A kind of poly- trehalose material provided by the invention has safety, has good biocompatibility, and the situation of wound tear will not occur when changing, and liquid absorption is big, and replacement frequency is low, sterile and antibacterial, and infection rate is low.
Description
Technical field：
The present invention relates to a kind of poly- trehalose material and preparation method thereof.
Background technology：
In clinical medicine, wound covering material is always in occupation of critical role.Because traditional wound covering material is mainly
Gauze, its adsorbance to wound location body fluid is few, opaque, it is difficult to wound situation is judged, it is necessary to frequently change, both to trouble
Person adds pain, adds the probability of wound infection again, is unfavorable for the healing of patient wound.Therefore, develop a kind of new
Wound covering material is imperative.
The content of the invention
Problem to be solved：Above reason is based on, the present invention utilizes positive negative gradient water bath heating, and freeze
Method, a kind of poly- trehalose material is prepared for, safe, cost is cheap, available for wrapping up wound, and also it is pollution-free.
Technical scheme
The purpose of the present invention can be achieved through the following technical solutions：
A kind of poly- trehalose material reaches 70% mainly by poly- trehalose hydrogel with reference to water content.
A kind of preparation method of poly- trehalose material, comprises the following steps：
Step 1. configuration concentration is the aqueous solution of 5% poly- trehalose；
Step 2. freezes 33-80 hours by the aqueous solution in step 1, at -20 °C to less than -25 DEG C, afterwards, is cooled to room
Temperature；Stand 3-10 hours；
The material obtained in step 2 is carried out water-bath by step 3., and bath temperature is 30 °C -40 °C, 30-40 minutes；
Bath temperature is 50 °C -60 °C, 20-30 minutes；Bath temperature is 80 °C -90 °C, 15-10 minutes；Bath temperature
For 100 °C, 5-10 minutes；
Step 3 resulting materials are placed -10 degrees Celsius of environment coolings, 8-10 hours by step 4,；
Step 5. takes out step 4 resulting materials, and bath temperature is 100 °C, 5-10 minutes；Bath temperature is 80 °C -90 °
C, 15-10 minute；Bath temperature is 50 °C -60 °C, 20-30 minutes；
Step 6. is placed into normal temperature, obtains material.
Described poly- trehalose material is used for wound lapping.
Beneficial effect:The use gradient water bath Method of the invention, by the way of positive and negative gradient temperature, and hormone
Freezing mode, poly- marine alga sugar chain is rebuild to interrupt, establishes gel rubber material.This method is pollution-free, simple possible, easy to operate, fits
Close extensive sound field.A kind of poly- trehalose material provided by the invention has safety, has good biocompatibility, is changing
The situation of wound tear occurs for Shi Buhui, and liquid absorption is big, and replacement frequency is low, sterile and antibacterial, and infection rate is low.
Embodiment
Embodiment 1
A kind of poly- trehalose material reaches 70% mainly by poly- trehalose hydrogel with reference to water content.
A kind of preparation method of poly- trehalose material, comprises the following steps：
Step 1. configuration concentration is the aqueous solution of 5% poly- trehalose；
The aqueous solution in step 1 is freezed 33 hours, afterwards, is cooled to room temperature by step 2. at -20 °C to less than -25 DEG C；It is quiet
Put 3 hours；
The material obtained in step 2 is carried out water-bath by step 3., and bath temperature is 30 °C °C, 40 minutes；
Bath temperature is 50 °C, 30 minutes；Bath temperature is 80 °C, 15 minutes；Bath temperature is 100 °C, 10 minutes；
Step 3 resulting materials are placed -10 degrees Celsius of environment and cooled down by step 4,8 hours；
Step 5. takes out step 4 resulting materials, and bath temperature is 100 °C, 10 minutes；Bath temperature is 80 °C, 15 minutes；
Bath temperature is 50 °C, 30 minutes；
Step 6. is placed into normal temperature, obtains material.
Described poly- trehalose material is used for wound lapping.
Embodiment 2
The poly- trehalose material of kind reaches 70% mainly by poly- trehalose hydrogel with reference to water content.
A kind of preparation method of poly- trehalose material, comprises the following steps：
Step 1. configuration concentration is the aqueous solution of 5% poly- trehalose；
The aqueous solution in step 1 is freezed 80 hours, afterwards, is cooled to room temperature by step 2. at -20 °C to less than -25 DEG C；It is quiet
Put 10 hours；
The material obtained in step 2 is carried out water-bath by step 3., and bath temperature is 40 °C, 30 minutes；
Bath temperature is 60 °C, 20 minutes；Bath temperature is 90 °C, 10 minutes；Bath temperature is 100 °C, 5 minutes；
Step 3 resulting materials are placed -10 degrees Celsius of environment and cooled down by step 4,8 hours；
Step 5. takes out step 4 resulting materials, and bath temperature is 100 °C, 5 minutes；Bath temperature is 90 °C, 10 minutes；
Bath temperature is 60 °C, 20 minutes；
Step 6. is placed into normal temperature, obtains material.
Described poly- trehalose material is used for wound lapping.
Embodiment 3
A kind of poly- trehalose material reaches 70% mainly by poly- trehalose hydrogel with reference to water content.
A kind of preparation method of poly- trehalose material, comprises the following steps：
Step 1. configuration concentration is the aqueous solution of 5% poly- trehalose；
The aqueous solution in step 1 after -20 °C to less than -25 DEG C freezings 54 hours, is cooled to room temperature by step 2.；It is quiet
Put 6.5 hours；
The material obtained in step 2 is carried out water-bath by step 3., and bath temperature is 35 °C, 35 minutes；
Bath temperature is 55 °C, 25 minutes；Bath temperature is 85 °C, 13 minutes；Bath temperature is 100 °C, 7 minutes；
Step 3 resulting materials are placed -10 degrees Celsius of environment and cooled down by step 4,9 hours；
Step 5. takes out step 4 resulting materials, and bath temperature is 100 °C, 7 minutes；Bath temperature is 85 °C, 13 minutes；Water
Bath temperature is 55 °C, 25 minutes；
Step 6. is placed into normal temperature, obtains material.
Described poly- trehalose material is used for wound lapping.
Claims (3)
1. a kind of poly- trehalose material, it is characterised in that mainly by poly- trehalose hydrogel, reach 70% with reference to water content.
2. a kind of preparation method of poly- trehalose material, it is characterised in that comprise the following steps：
Step 1. configuration concentration is the aqueous solution of 5% poly- trehalose；
Step 2. freezes 33-80 hours by the aqueous solution in step 1, at -20 °C to less than -25 DEG C, afterwards, is cooled to room
Temperature；Stand 3-10 hours；
The material obtained in step 2 is carried out water-bath by step 3., and bath temperature is 30 °C -40 °C, 30-40 minutes；
Bath temperature is 50 °C -60 °C, 20-30 minutes；Bath temperature is 80 °C -90 °C, 15-10 minutes；Bath temperature
For 100 °C, 5-10 minutes；
Step 3 resulting materials are placed -10 degrees Celsius of environment coolings, 8-10 hours by step 4,；
Step 5. takes out step 4 resulting materials, and bath temperature is 100 °C, 5-10 minutes；Bath temperature is 80 °C -90 °
C, 15-10 minute；Bath temperature is 50 °C -60 °C, 20-30 minutes；
Step 6. is placed into normal temperature, obtains material.
3. a kind of poly- trehalose material according to claim 1, it is characterised in that described poly- trehalose material is used to hinder
Mouth lapping.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610715634.4A CN107773780A (en) | 2016-08-25 | 2016-08-25 | A kind of poly- trehalose material and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610715634.4A CN107773780A (en) | 2016-08-25 | 2016-08-25 | A kind of poly- trehalose material and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107773780A true CN107773780A (en) | 2018-03-09 |
Family
ID=61388389
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610715634.4A Withdrawn CN107773780A (en) | 2016-08-25 | 2016-08-25 | A kind of poly- trehalose material and preparation method thereof |
Country Status (1)
| Country | Link |
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| CN (1) | CN107773780A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114133460A (en) * | 2021-12-03 | 2022-03-04 | 山东福洋生物科技股份有限公司 | Polytrehalose and preparation method thereof |
-
2016
- 2016-08-25 CN CN201610715634.4A patent/CN107773780A/en not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114133460A (en) * | 2021-12-03 | 2022-03-04 | 山东福洋生物科技股份有限公司 | Polytrehalose and preparation method thereof |
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| Date | Code | Title | Description |
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| PB01 | Publication | ||
| PB01 | Publication | ||
| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20180309 |