CN107773238A - A kind of cardiac electrophysiology program stimulation instrument - Google Patents
A kind of cardiac electrophysiology program stimulation instrument Download PDFInfo
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- CN107773238A CN107773238A CN201610720795.2A CN201610720795A CN107773238A CN 107773238 A CN107773238 A CN 107773238A CN 201610720795 A CN201610720795 A CN 201610720795A CN 107773238 A CN107773238 A CN 107773238A
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- stimulation
- stimulating
- pulse
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- microcontroller
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
- A61B2560/02—Operational features
Abstract
The invention discloses a kind of cardiac electrophysiology program stimulation instrument, including：Stimulation instructions maker, generation microcontroller is stimulated, monitoring microcontroller is stimulated, stimulates output module, stimulates detection module and switching device, wherein, monitoring microcontroller is stimulated with stimulating detection module to be connected, pulse characteristicses parameter and the matching factor of the stimulation instructions received from stimulation instructions maker are detected for calculating from stimulate detection module to receive first, when matching factor exceeds preset threshold range, being closed by switching device stimulates output module.The cardiac electrophysiology program stimulation instrument can realize the closed-loop control of cardiac electrophysiology program stimulation, effectively prevent because hardware or software failure causes to stimulate output to exceed secure threshold, and then avoid the generation of malpractice.
Description
Technical field
The present invention relates to electronic technology field, more particularly to a kind of cardiac electrophysiology program stimulation instrument.
Background technology
Electrophysiological technique (Electrophysiological Techniques) is energy (electricity, sound in a variety of forms
Deng) stimulating organism body, the electrical phenomena (biological electricity) and the skill of the electrical characteristics of organism that measurement, record and analysis organism occur
Art, it is the major technique of electrophysiologic studies.Cardiac electrophysiology is using a part for overall heart or heart as object, records the heart
Interior electrocardiogram, mapping electrocardiogram and the various specific electric pulse stimulations of application, use one kind side of diagnosis and research arrhythmia cordis
Method.
It is a kind of instrument for being used to diagnose arrhythmia cordis that procedural cardiac electrophysiology, which stimulates, and it is in patient's autonomous cardiac rhythm or rises
Fight on the basis of the rhythm and pace of moving things, send one or more electric pulses using heart program stimulating, stimulate atrium or ventricle, form simulation
Room morning or room are early, to observe the reaction that patient's premature beat different to these coupling intervals stimulates.This induction and the duplication rhythm of the heart loses
Normal technology is commonly referred to as heart program stimulating method.
Generally use opened loop control (Open-Loop Control) in the prior art, its controlled object is not to controlling main body
Reaction is produced, also in the absence of backfeed loop.Therefore, in case of a fault, such as hardware microcontroller, crystal oscillator, clock failure,
And software program leak or defect etc. may cause the output of mistake, and then cause malpractice.
The content of the invention
An object of the present invention at least that, in view of the above-mentioned problems of the prior art, providing a kind of life of cardiac electric
Program stimulation instrument is managed, the closed-loop control of cardiac electrophysiology program stimulation can be realized, effectively prevented because hardware or software failure is led
Cause to stimulate output to exceed secure threshold, and then avoid the generation of malpractice.
To achieve these goals, the technical solution adopted by the present invention is：
A kind of cardiac electrophysiology program stimulation instrument, including：Stimulation instructions maker, stimulate generation microcontroller, stimulate prison
Microcontroller is controlled, output module is stimulated, stimulates detection module and switching device；Wherein,
Stimulation instructions maker, the stimulation for obtaining user's setting by graphic user interface or input unit are joined
Number, stimulation instructions are generated, stimulation instructions are sent into stimulation by the first data-interface respectively occurs microcontroller, passes through second
Stimulation instructions are sent to stimulation monitoring microcontroller by data-interface；
Stimulate and microcontroller occurs with stimulating output module to be connected, for according to the electricity of stimulation instructions generation first received
Boost pulse, by stimulating output module to stimulate stimulation target；
Stimulate detection module respectively with stimulating output module and stimulating monitoring microcontroller to be connected, for exporting mould from stimulation
Block obtains the first detection pulse characteristicses parameter in real time, and special to stimulating monitoring microcontroller to send the first acquired detection pulse
Levy parameter；
Monitoring microcontroller is stimulated with stimulating detection module to be connected, for calculating from the first inspection for stimulating detection module to receive
Pulse characteristicses parameter and the matching factor of the stimulation instructions received from stimulation instructions maker are surveyed, when matching factor exceeds default threshold
When being worth scope, being closed by switching device stimulates output module.
Preferably, above-mentioned stimulation parameter includes：Stimulation target, stimulus modality and stimulation object physiological characteristic.
Preferably, above-mentioned stimulation instructions include：Phase between impulse waveform, impulse amplitude, pulse width and simulation.
Preferably, microcontroller, which occurs, for above-mentioned stimulation includes：
D/A converting circuit, for generating the first electric stimulation pulse of corresponding waveform according to stimulation instructions；
Pulse amplitude modulation switching power circuit, for modulating the first generated electric stimulation pulse according to stimulation instructions
Amplitude；
Pulse width modulation circuit, for modulating the width of the first generated electric stimulation pulse according to stimulation instructions；
Timing circuit, phase between the simulation for setting stimulation.
Preferably, above-mentioned stimulation detection module includes：
Modulus sample circuit, with stimulating the sparking electrode of output module to be connected, for each electricity on sparking electrode
Boost pulse is sampled, and obtains waveform and amplitude of each detection pulse, and, stimulate the load impedance of object；
Counter circuit, it is connected with modulus sample circuit, for being counted to each acquired detection pulse, obtains
Take the first detection pulse width and stimulate the phase between simulation.
Preferably, above-mentioned cardiac electrophysiology program stimulation instrument also includes the warning output with stimulating monitoring microcontroller to be connected
Device, for when matching factor exceeds preset threshold range, the alarm of generation sound, light or electric form.
Preferably, above-mentioned stimulation target is atrium and/or ventricle；Stimulus modality is current-output type stimulation or voltage output
Type stimulates.
Preferably, above-mentioned stimulation instructions include：Impulse waveform is square wave, impulse amplitude is 0.1mA~25mA or 0.1V~
The phase is 30ms~9999ms between 8V, pulse width are 0.5ms~10ms and simulated.
In summary, by adopting the above-described technical solution, the present invention at least has the advantages that：
By stimulating monitoring microcontroller to be supervised with stimulating detection module to stimulate in real time the output for stimulating output module
Control, it is defeated to close stimulation immediately when the matching factor of the first detection pulse characteristicses parameter and stimulation instructions exceeds preset threshold range
Go out module, realize the closed-loop control of cardiac electrophysiology program stimulation, can effectively prevent because hardware or software failure causes to pierce
Swash output and exceed secure threshold, and then avoid the generation of malpractice.
Brief description of the drawings
Fig. 1 is the structural representation for the cardiac electrophysiology program stimulation instrument that the embodiment of the present invention one provides；
Fig. 2 is the structural representation for the cardiac electrophysiology program stimulation instrument that the embodiment of the present invention two provides.
Embodiment
Below in conjunction with the accompanying drawings and embodiment, the present invention will be described in further detail, so that the purpose of the present invention, technology
Scheme and advantage are more clearly understood.It should be appreciated that specific embodiment described herein is only to explain the present invention, and do not have to
It is of the invention in limiting.
Embodiment one
As shown in figure 1, the disclosed kind cardiac electrophysiology program stimulation instrument of the embodiment of the present invention one includes：Stimulation instructions generate
Device, generation microcontroller is stimulated, monitoring microcontroller is stimulated, stimulates output module, stimulates detection module and switching device；
Wherein,
Stimulation instructions maker, the stimulation for obtaining user's setting by graphic user interface or input unit are joined
Number, stimulation instructions are generated, stimulation instructions are sent into stimulation by the first data-interface respectively occurs microcontroller, passes through second
Stimulation instructions are sent to stimulation monitoring microcontroller by data-interface；Wherein, stimulation parameter can include：Stimulation target (for example,
Atrium, ventricle, atrium and ventricle etc.), stimulus modality (for example, current-output type stimulate, voltage output type stimulate etc.) and thorn
Swash object physiological characteristic (for example, stimulating the electro physiology waveform of object, blood pressure, pulse etc.)；Stimulation instructions can include：Impulse wave
Shape (for example, sine wave, square wave, asymmetric sharp wave etc.), impulse amplitude (for example, 0.1mA~25mA), pulse width (for example,
0.5ms~10ms) and simulation between the phase (Distance Time of R crests in adjacent cardiac twice being simulated, for example, 0.5s~1s).
Stimulate and microcontroller occurs with stimulating output module to be connected, for according to the electricity of stimulation instructions generation first received
Boost pulse, by stimulating output module to stimulate stimulation target；
Stimulate detection module respectively with stimulating output module and stimulating monitoring microcontroller to be connected, for exporting mould from stimulation
Block obtains the first detection pulse characteristicses parameter in real time, and special to stimulating monitoring microcontroller to send the first acquired detection pulse
Levy parameter；Wherein, the first detection pulse characteristicses parameter includes：Phase between waveform, impulse amplitude, pulse width and simulation.
Monitoring microcontroller is stimulated with stimulating detection module to be connected, for calculating from the first inspection for stimulating detection module to receive
Pulse characteristicses parameter and the matching factor of the stimulation instructions received from stimulation instructions maker are surveyed, when matching factor exceeds default threshold
When being worth scope, being closed by switching device stimulates output module.
In above-described embodiment, by stimulating monitoring microcontroller with stimulating detection module in real time to stimulating the defeated of output module
Go out stimulation to be monitored, stood when the matching factor of the first detection pulse characteristicses parameter and stimulation instructions exceeds preset threshold range
Closing stimulates output module, realizes the closed-loop control of cardiac electrophysiology program stimulation, can effectively prevent because of hardware or soft
Part failure causes to stimulate output to exceed secure threshold, and then avoids the generation of malpractice.
Embodiment two
Carried out specifically below in conjunction with the cardiac electrophysiology program stimulation instrument that Fig. 2 is provided the preferred embodiments of the present invention two
It is bright.
In actual applications, user can set stimulation parameter by graphic user interface, and it can include：Stimulation target
For atrium, stimulus modality be simulate atrial premature beats, stimulate object systolic blood pressure be 112mmHg, diastolic blood pressure 65mmHg, arteries and veins
Fight as 78 beats/min.Stimulation instructions maker generates stimulation instructions according to stimulation parameter to be included：Impulse waveform is square wave, pulse width
It is 800ms to spend the phase between 1V, pulse width 0.5ms and simulation.
Stimulation instructions maker is sent stimulation instructions by RS-232 serial data interfaces or CAN data-interface
Microcontroller occurs to stimulating, stimulates generation microcontroller to generate waveform by its D/A converting circuit and is pierced for the first electricity of square wave
Swash pulse；By the amplitude modulation(PAM) of the square wave generated it is 1V by its pulse amplitude modulation switching power circuit；Pass through its pulse
Width modulation circuit, the pulse width for setting the first electric stimulation pulse is 0.5ms；By its timing circuit, the phase between simulation is set
For 0.5ms；By stimulating the sparking electrode of output module to stimulate stimulation target.
The modulus sample circuit in detection module is stimulated to be connected with sparking electrode, to each electro photoluminescence on sparking electrode
Pulse is sampled, and the waveform for obtaining each detection pulse is the load resistance of square wave, impulse amplitude 1V, and stimulation object
It is anti-；Stimulate the counter circuit in detection module to count each acquired detection pulse, obtain each detection
Pulse pulse width, for example, 0.5ms, it is determined that phase, for example, 800ms between the simulation stimulated.
Monitoring microcontroller is stimulated to calculate the matching of the first detection pulse characteristicses parameter and the parameters in stimulation instructions
Coefficient, for example, the impulse amplitude of the first detection pulse is 1V, the impulse amplitude of stimulation instructions is 0.8V, can obtain matching system
Number is 80%, and it exceeds preset threshold range [99%~101%].Therefore, monitoring microcontroller is stimulated to pass through relay switch
Circuit closes stimulation output module immediately, so as to ensure the physiological safety of stimulation target.
In a preferred embodiment, can also be by monitoring microcontroller with stimulating while stimulation output module is closed
The acousto-optic-electric alarm output device of device connection is alarmed, and reminds operator to take appropriate measures in time, for example, change stimulates
Parameter setting.
Embodiment of above is merely to illustrate presently preferred embodiments of the present invention, rather than limitation of the present invention.Correlation technique
The technical staff in field is not in the case where departing from the principle and scope of the present invention, various replacements, modification and the improvement made
It should be included in the scope of the protection.
Claims (8)
1. a kind of cardiac electrophysiology program stimulation instrument, it is characterised in that the cardiac electrophysiology program stimulation instrument includes：Stimulation refers to
Maker is made, generation microcontroller is stimulated, stimulates monitoring microcontroller, stimulates output module, stimulating detection module and switch
Device；Wherein,
Stimulation instructions maker, it is raw for obtaining the stimulation parameter of user's setting by graphic user interface or input unit
Into stimulation instructions, stimulation instructions are sent to by stimulation by the first data-interface respectively microcontroller occurs, pass through the second data
Stimulation instructions are sent to stimulation monitoring microcontroller by interface；
Stimulate and microcontroller occurs with stimulating output module to be connected, for generating the first electro photoluminescence according to the stimulation instructions received
Pulse, by stimulating output module to stimulate stimulation target；
Stimulate detection module respectively with stimulating output module and stimulating monitoring microcontroller to be connected, for real from stimulation output module
When obtain the first detection pulse characteristicses parameter, and to stimulating monitoring microcontroller to send the first acquired detection pulse characteristicses ginseng
Number；
Monitoring microcontroller is stimulated with stimulating detection module to be connected, for calculating from the first detection arteries and veins for stimulating detection module to receive
Characteristic parameter and the matching factor of the stimulation instructions received from stimulation instructions maker are rushed, when matching factor exceeds predetermined threshold value model
When enclosing, being closed by switching device stimulates output module.
2. cardiac electrophysiology program stimulation instrument according to claim 1, it is characterised in that the stimulation parameter includes：Thorn
Swash target, stimulus modality and stimulate object physiological characteristic.
3. cardiac electrophysiology program stimulation instrument according to claim 1, it is characterised in that the stimulation instructions include：Arteries and veins
Rush waveform, impulse amplitude, pulse width and simulation between the phase.
4. cardiac electrophysiology program stimulation instrument according to claim 3, it is characterised in that microcontroller occurs for described stimulate
Including：
D/A converting circuit, for generating the first electric stimulation pulse of corresponding waveform according to stimulation instructions；
Pulse amplitude modulation switching power circuit, for modulating the width of the first generated electric stimulation pulse according to stimulation instructions
Degree；
Pulse width modulation circuit, for modulating the width of the first generated electric stimulation pulse according to stimulation instructions；
Timing circuit, phase between the simulation for setting stimulation.
5. cardiac electrophysiology program stimulation instrument according to claim 2, it is characterised in that the stimulation detection module bag
Include：
Modulus sample circuit, with stimulating the sparking electrode of output module to be connected, for each electro photoluminescence on sparking electrode
Pulse is sampled, and obtains waveform and amplitude of each detection pulse, and, stimulate the load impedance of object；
Counter circuit, it is connected with modulus sample circuit, for being counted to each acquired detection pulse, obtains the
Phase between one detection pulse width and stimulation simulation.
6. cardiac electrophysiology program stimulation instrument according to any one of claim 1 to 5, it is characterised in that the heart
Electro physiology program stimulation instrument also includes the alarm output device with stimulating monitoring microcontroller to be connected, for exceeding when matching factor
During preset threshold range, the alarm of generation sound, light or electric form.
7. cardiac electrophysiology program stimulation instrument according to claim 6, it is characterised in that the stimulation target is atrium
And/or ventricle；Stimulus modality is that current-output type stimulates or voltage output type stimulates.
8. cardiac electrophysiology program stimulation instrument according to claim 7, it is characterised in that the stimulation instructions include：Arteries and veins
Rush that waveform is square wave, impulse amplitude is 0.1mA~25mA or 0.1V~8V, pulse width are between 0.5ms~10ms and simulation
Phase is 30ms~9999ms.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610720795.2A CN107773238A (en) | 2016-08-24 | 2016-08-24 | A kind of cardiac electrophysiology program stimulation instrument |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610720795.2A CN107773238A (en) | 2016-08-24 | 2016-08-24 | A kind of cardiac electrophysiology program stimulation instrument |
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| CN201610720795.2A Pending CN107773238A (en) | 2016-08-24 | 2016-08-24 | A kind of cardiac electrophysiology program stimulation instrument |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023011641A1 (en) * | 2021-08-05 | 2023-02-09 | 合源医疗器械(上海)有限公司 | Pulse stimulation device and method, and medical apparatus |
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|---|---|---|---|---|
| EP0922468A1 (en) * | 1997-12-11 | 1999-06-16 | Pacesetter, Inc. | Automatic capture detection during non-invasive programmed stimulation of a patient's heart |
| US6453197B1 (en) * | 2000-04-18 | 2002-09-17 | Pacesetter, Inc. | Implantable cardiac stimulation device including a system for and method of automatically inducing a tachyarrhythmia |
| US6847843B1 (en) * | 2001-06-06 | 2005-01-25 | Pacesetter, Inc. | Method and apparatus for electrophysiological testing in an implantable device |
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| CN103893914A (en) * | 2014-03-05 | 2014-07-02 | 复旦大学 | Program control multichannel electrophysiological stimulator |
| CN104922794A (en) * | 2015-07-07 | 2015-09-23 | 北京品驰医疗设备有限公司 | Position evaluation apparatus of testing stimulation electrode |
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| WO2023011641A1 (en) * | 2021-08-05 | 2023-02-09 | 合源医疗器械(上海)有限公司 | Pulse stimulation device and method, and medical apparatus |
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