CN107754004A - A kind of adhesive bandage and its preparation and application - Google Patents
A kind of adhesive bandage and its preparation and application Download PDFInfo
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- CN107754004A CN107754004A CN201710939963.1A CN201710939963A CN107754004A CN 107754004 A CN107754004 A CN 107754004A CN 201710939963 A CN201710939963 A CN 201710939963A CN 107754004 A CN107754004 A CN 107754004A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/20—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing organic materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/108—Elemental carbon, e.g. charcoal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/216—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with other specific functional groups, e.g. aldehydes, ketones, phenols, quaternary phosphonium groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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- Materials Engineering (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention proposes one kind and is based on gold nanoclusters graphene composite material（AuNCs‑GO）And ascorbic acid（AA）Adhesive bandage be used for wound disinfection new method.Gold nanoclusters graphene composite material has high near infrared light（NIR）Absorption and peroxidase activity, it can effectively be catalyzed decomposing hydrogen dioxide solution caused by prodrug ascorbic acid and produce the hydroxyl radical free radical with high antibacterial activity, so as to avoid the toxicity of high concentration hydrogen peroxide.Due to possessing chemotherapy/photo-thermal synergistic therapeutic action, the antibacterial system designed by us has wide spectrum and efficient antibacterial activity, can speed up the healing of wound.
Description
Technical field
The present invention relates to nano biological medical domain, specially a kind of adhesive bandage and its preparation and application.
Background technology
At present, bacterial infectious disease is still one of global maximum health problem, is annoying every year millions of
People, therefore, anti-biotic material is widely used in daily life, effectively protects public health.Traditional antibacterial strategy is main
It is to be based on antibiotic, metal ion and quaternary ammonium salt, these all have the shortcomings that eco-toxicity, cost height, environmental hazard.In addition,
Hydrogen peroxide（H2O2）Also it is widely used as sterilizing reagent, however, traditional hydrogen peroxide concentration（Volume ratio：0.5-3%）Hinder thin
Wound healing in bacterium disinfecting process, or even infringement normal structure.Adhesive bandage is widely used in wound dressing and avoids bacterium sense
Dye.Although the active ingredient benzalkonium chloride of adhesive bandage can cause some adverse reactions, such as allergy with excellent antibacterial activity
Property rhinitis box rhinitis medicamentosa etc..
The content of the invention
The present invention is directed to above weak point, and adhesive bandage is used as by the use of gold nanoclusters-graphene composite material and ascorbic acid
Ground is used for wound disinfection.Gold nanoclusters-graphene composite material has high peroxidase activity in the range of extensive pH,
Decomposing hydrogen dioxide solution caused by prodrug ascorbic acid can be effectively catalyzed and produce the hydroxyl radical free radical with high antibacterial activity, so as to avoid
The toxicity of high concentration hydrogen peroxide.Wide spectrum and efficient antibacterial can be realized under chemotherapy/photo-thermal synergistic therapeutic action, so as to accelerate
The healing of wound.
The technical solution adopted for the present invention to solve the technical problems is：A kind of adhesive bandage, the adhesive bandage use Jenner
Rice cluster-graphene composite material and ascorbic acid are as ground.
A kind of preparation method of adhesive bandage, comprising having the following steps：
（1）30-50mg BSA are dissolved in 6 mL water by the preparation of gold nanoclusters-graphene composite material, then add 800 μ L
20 mM gold chlorides and 3 mL water, 5 min are mixed, then add 400-500 μ L 1M NaOH, 12 h are stirred at 37 DEG C, make
Obtain gold nanoclusters；Then 40-60 μ g/mL graphene oxides and 1nM gold nanoclusters are reacted at room temperature 10 in phosphate buffer
Min, gold nanoclusters-graphene composite material is made.
（2）The medical cotton of square is installed in the preparation of adhesive bandage on negative pressure leaching device, and addition concentration is 1.5 mg/
Gold nanoclusters-graphene composite material solution made from mL upper step, solution is set to repeat the suction filtration process, directly by medical cotton
Absorbed completely by medical cotton to solution；10 mg/mL ascorbic acid 300-500 μ L are added dropwise, then by medical cotton in 60 DEG C of vacuum
Dry 3 hours, finally the yellow sample of gained is fixed in dressing, GQDs adhesive bandages have been made.
A kind of application method of adhesive bandage, the adhesive bandage on mouse adhesive bandage, then divided with 808 nm near infrared lights 5
Clock, power level are 6 W/cm2。
The beneficial effects of the invention are as follows：
（1）Ascorbic acid is a kind of required nutrient for some mammals, and it is a kind of effective antioxidant,
Protect life entity from the injury of free radical.On the other hand, H can be served as a kind of precursor of oxidant, ascorbic acid2O2's
Prodrug, for treating the bacterium infection of drug resistance, the toxic side effect of hydrogen peroxide can be reduced；
（2）Gold nanoclusters-graphene composite material has high peroxidase activity in the range of extensive pH, in physiological condition
Under still there is very high activity, can effectively facilitate hydrogen peroxide catalysis generation hydroxyl radical free radical；
（3）Gold nanoclusters-graphene composite material has high near-infrared absorption, and photo-thermal sterilization can be achieved；
（4）Medicine/photo-thermal collaboration bacterium treatment can be realized, therapeutic effect is good, reduces drug dose.
Brief description of the drawings
Fig. 1 is gold nanoclusters-graphene composite material peroxidase activity kinetic curve；
Fig. 2 is the pH dependences of gold nanoclusters-graphene composite material peroxidase activity；
Fig. 3 is gold nanoclusters-graphene composite material of various concentrations in 808 nm near infrared light lasers（6 W/cm2）Irradiation
Under photo-thermal curve；
Fig. 4 is that staphylococcus aureus is incubated group's photo after 8 h altogether with various materials under 37 °C：A：Control group bacterium；B：
AuNCs-GO+NIR；C：AuNCs-GO+AA；D：AuNCs-GO+AA+NIR；
Fig. 5 is the wound photo of four groups of mouse after treatment：A：Control group bacterium；B：AuNCs-GO+NIR；C：AuNCs-GO+AA；
D：AuNCs-GO+AA+NIR；
Fig. 6 is the clump count of surviving bacteria in quantitative wound tissue.
Embodiment
The present invention will be described in detail with specific embodiment below in conjunction with the accompanying drawings：
Embodiment 1
A kind of preparation method of adhesive bandage, comprising having the following steps：
（1）40 mg bovine serum albumin BSAs are dissolved in 6 mL water by the preparation of gold nanoclusters-graphene composite material, Ran Houjia
Enter the mM of 800 μ L 20 gold chloride and 3 mL water, mix 5 min, then add 400 μ L 1M NaOH, stirred at 37 DEG C
12 h, gold nanoclusters are made.Then by 50 μ g/mL graphene oxides and 1 nM gold nanoclusters in phosphate buffer（25 mM,
pH 7.0）10 min of middle room temperature reaction, gold nanoclusters-graphene composite material is made.
(2) medical cotton of square is installed in the preparation of adhesive bandage on negative pressure leaching device, dense made from step in addition
The gold nanoclusters for 1.5 mg/mL-graphene composite material solution is spent, solution is passed through medical cotton.The suction filtration process is repeated, directly
Absorbed completely by medical cotton to solution.The μ L of 10 mg/mL ascorbic acid 400 are added dropwise, then by medical cotton in 60 DEG C of vacuum drying
About 3 hours, finally the yellow sample of gained is fixed in dressing, GQDs adhesive bandages have been made.
Embodiment 2
A kind of preparation method of adhesive bandage, comprising having the following steps：
（1）30 mg bovine serum albumin BSAs are dissolved in 6 mL water by the preparation of gold nanoclusters-graphene composite material, Ran Houjia
Enter the mM of 800 μ L 20 gold chloride and 3 mL water, mix 5 min, then add 450 μ L 1M NaOH, stirred at 37 DEG C
12 h, gold nanoclusters are made.Then by 40 μ g/mL graphene oxides and 1 nM gold nanoclusters in phosphate buffer（25 mM,
pH 7.0）10 min of middle room temperature reaction, gold nanoclusters-graphene composite material is made.
(2) medical cotton of square is installed in the preparation of adhesive bandage on negative pressure leaching device, dense made from step in addition
The gold nanoclusters for 1.5 mg/mL-graphene composite material solution is spent, solution is passed through medical cotton.The suction filtration process is repeated, directly
Absorbed completely by medical cotton to solution.The μ L of 10 mg/mL ascorbic acid 300 are added dropwise, are then dried in vacuo medical cotton about at 60 DEG C
3 hours, finally the yellow sample of gained is fixed in dressing, GQDs adhesive bandages have been made.
Embodiment 3
A kind of preparation method of adhesive bandage, comprising having the following steps：
（1）50 mg bovine serum albumin BSAs are dissolved in 6 mL water by the preparation of gold nanoclusters-graphene composite material, Ran Houjia
Enter the mM of 800 μ L 20 gold chloride and 3 mL water, mix 5 min, then add 500 μ L 1M NaOH, stirred at 37 DEG C
12 h, gold nanoclusters are made.Then by 60 μ g/mL graphene oxides and 1 nM gold nanoclusters in phosphate buffer（25 mM,
pH 7.0）10 min of middle room temperature reaction, gold nanoclusters-graphene composite material is made.
(2) medical cotton of square is installed in the preparation of adhesive bandage on negative pressure leaching device, dense made from step in addition
The gold nanoclusters for 1.5 mg/mL-graphene composite material solution is spent, solution is passed through medical cotton.The suction filtration process is repeated, directly
Absorbed completely by medical cotton to solution.The μ L of 10 mg/mL ascorbic acid 500 are added dropwise, then by medical cotton in 60 DEG C of vacuum drying
About 3 hours, finally the yellow sample of gained is fixed in dressing, GQDs adhesive bandages have been made.
The property measure of gold nanoclusters-graphene composite material
The measure of peroxidase activity is by 100 μ g/mL gold nanoclusters-graphene composite material, 50 mM H2O2With 2.5
MM ABTS are dissolved in 500 μ L buffer solutions（25 mM PBS, pH 7.4）In be measured at 37 DEG C, at 417 nm record inhale
Luminosity changes with time（See Fig. 1）.PH dependences are determined in different pH 25 mM PBS（See Fig. 2）.
Test result indicates that gold nanoclusters-graphene composite material all has very high mistake in the range of very extensive pH
Peroxidase activity, remain to keep 76% enzymatic activity under pH 7.4 physiological condition（With the enzymatic activity phase under pH 3.0
Than）, it is highly suitable in living animal.
The photo-thermal effect of gold nanoclusters-graphene composite material
In order to investigate influence of the nanoparticle concentration to photo-thermal effect, we are by 5,10 and 20 μ g/mL various concentrations gold nanos
Cluster-graphene composite material is dispersed in pH 7.4 PBS, irradiates 5 min near infrared laser（808 nm, 6 W/cm2）.
A solution temperature was determined every 30 seconds with thermometer, recording solution temperature changes with time.PH 7.4 PBS is used in experiment
As negative control.
Test result indicates that the photo-thermal effect of nano material changes with change in concentration（Fig. 3）.When concentration is 20 μ g/mL
When, the temperature of solution reached 45 DEG C at 5 minutes.By comparing, it is same under conditions of PBS temperature without notable rise.
Antibacterial experiment（See Fig. 4）
A：Bacterial colony on solid medium is transferred in 20 mL LB fluid nutrient mediums, and shaken at 37 DEG C in bacterium
12 h are cultivated under conditions of bed rotating speed 180 rpm.Then bacterium is diluted to 10 with culture medium6 cfu mL-1.Take 500 μ L dilute
The method that bacterium liquid after releasing is spread by spin coating is taped against on solid medium, cultivates 24 h, observes the number of bacterial clump.
B：Use the bacterial solution of cultural method culture and 200 μ g/mL gold nanoclusters-graphene in A compound 500 μ L
Material mixes 10 min.Used for 808 nm near infrared light times as 5 minutes, power level is 6 W/cm2.Then, by this
The method that solution is spread by spin coating is taped against on solid medium, cultivates 24 h, observes the number of bacterial clump.
C：Use the bacterial solution of cultural method culture and 200 μ g/mL gold nanoclusters-graphene in A compound 500 μ L
Material and 2 mg/mL ascorbic acid mix 10 min.Then, the method that the solution is spread by spin coating is taped against solid medium
On, 24 h are cultivated, observe the number of bacterial clump.
D：Use the bacterial solution of cultural method culture and 200 μ g/mL gold nanoclusters-graphene in A compound 500 μ L
Material and 2 mg/mL ascorbic acid mix 10 min.Used for 808 nm near infrared light times as 5 minutes, power level 6
W/cm2.Then, the method that the solution is spread by spin coating is taped against on solid medium, cultivates 24 h, observe bacterial clump
Number.
With control group（Fig. 4 A）Compare, near infrared light shines（Fig. 4 B）Bacterium can be effectively killed, gold nanoclusters-graphene is multiple
Condensation material and ascorbic acid combination（Fig. 4 C）The formation of bacterial clump can also effectively be suppressed, and photo-thermal therapy and chemotherapy cooperate with
Treatment group（Fig. 4 D）With last bactericidal effect, the formation of bacterium colony can be almost entirely prevented.
Adhesive bandage effect experiment（Fig. 5,6）
Surgical wound model：There are about 4 mm at 12 backs2The male mouse of kunming of wound（6-8 weeks, 18-22 grams, every group 3）It is divided into four
Group, 100 μ L bacterial suspensions（108 cfu mL-1）Drip on wound, bacterial suspension can use staphylococcus aureus or
MRSE or Escherichia coli or Pseudomonas aeruginosa, in figure result using staphylococcus aureus, then four groups it is different
The wound of mouse is treated with different adhesive bandages, respectively brackish water in adhesive bandage, multiple containing gold nanoclusters-graphene in adhesive bandage
Condensation material+NIR, contain gold nanoclusters-graphene composite material+ascorbic acid in adhesive bandage, contain gold nanoclusters-graphite in adhesive bandage
Alkene composite+ascorbic acid+NIR；NIR is meant：Shone on mouse adhesive bandage after adhesive bandage with 808 nm near infrared lights
Penetrate 5 minutes, power level is 6 W/cm2.Every 24 h, the wound of mouse is taken pictures, changes adhesive bandage.After 3 days, put to death
All mouse, and the tissue of wound is cut, to determine the quantity of bacterium in the tissue of wound.Over the course for the treatment of, four groups
Mouse weight there is no significant change, but the state of its wound is different（Fig. 5）.Three treatment group's wounds have difference
The healing of degree, the bacterial number ratio in wound tissue are remarkably decreased with saline therapy group（Fig. 6）.Wherein, gold nano is used
Cluster-graphene composite material+ascorbic acid+NIR groups have best therapeutic effect, and the wound of adhesive bandage processing is entirely being treated
During without there is any erythema and oedema, after treating 72h, it is observed that in the group mouse wound incrustation, wound
Bacterium in tissue is almost entirely killed.
Certainly, described above is not limitation of the present invention, and the present invention is also not limited to the example above, this technology neck
The variations, modifications, additions or substitutions that the technical staff in domain is made in the essential scope of the present invention, it should also belong to the present invention's
Protection domain.
Claims (3)
1. a kind of adhesive bandage, it is characterised in that the adhesive bandage is made using gold nanoclusters-graphene composite material and ascorbic acid
For ground.
2. a kind of preparation method of adhesive bandage as claimed in claim 1, it is characterised in that comprising having the following steps：
（1）30-50mg BSA are dissolved in 6 mL water by the preparation of gold nanoclusters-graphene composite material, then add 800 μ L
20 mM gold chlorides and 3 mL water, 5 min are mixed, then add 400-500 μ L 1M NaOH, 12 h are stirred at 37 DEG C, make
Obtain gold nanoclusters；Then 40-60 μ g/mL graphene oxides and 1nM gold nanoclusters are reacted at room temperature 10 in phosphate buffer
Min, gold nanoclusters-graphene composite material is made；
（2）The medical cotton of square is installed in the preparation of adhesive bandage on negative pressure leaching device, and it is 1.5 mg/mL's to add concentration
Gold nanoclusters made from upper step-graphene composite material solution, solution is set to repeat the suction filtration process, Zhi Daorong by medical cotton
Liquid is absorbed by medical cotton completely；10 mg/mL ascorbic acid 300-500 μ L are added dropwise, medical cotton is then dried in vacuo 3 at 60 DEG C
Hour, finally the yellow sample of gained is fixed in dressing, GQDs adhesive bandages have been made.
A kind of 3. application method of adhesive bandage as claimed in claim 1, it is characterised in that the adhesive bandage on mouse adhesive bandage,
Then with 808 nm near infrared lights 5 minutes, power level is 6 W/cm2。
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| CN201710939963.1A CN107754004A (en) | 2017-10-11 | 2017-10-11 | A kind of adhesive bandage and its preparation and application |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108420803A (en) * | 2018-04-28 | 2018-08-21 | 中国科学院长春应用化学研究所 | Nano enzyme adhesive bandage, preparation method and application method |
| CN109875762A (en) * | 2018-12-25 | 2019-06-14 | 浙江工商大学 | A kind of novel antibacterial adhesive bandage and the preparation method and application thereof |
| IT201900024132A1 (en) * | 2019-12-16 | 2021-06-16 | Idi Integratori Dietetici Italiani S R L | MIXTURE AND COMPOSITIONS BASED ON GOLD AND GRAPHENE, AND THEIR USE. |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140186860A1 (en) * | 2002-10-10 | 2014-07-03 | Cornell University | Novel immunogenic proteins of leptospira |
| CN105377749A (en) * | 2013-05-06 | 2016-03-02 | 巴伊兰大学 | Doped metal oxide nanoparticles of and uses thereof |
| CN106190112A (en) * | 2016-07-10 | 2016-12-07 | 东北师范大学 | The preparation method and applications of gold quantum dot |
| CN107041876A (en) * | 2017-03-17 | 2017-08-15 | 泰山医学院 | A kind of nano particle for killing cancer cell and preparation method thereof |
| CN107234238A (en) * | 2017-05-03 | 2017-10-10 | 太原理工大学 | A kind of core shell structure Au@Co (OH)2The preparation method of nanoparticle |
-
2017
- 2017-10-11 CN CN201710939963.1A patent/CN107754004A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140186860A1 (en) * | 2002-10-10 | 2014-07-03 | Cornell University | Novel immunogenic proteins of leptospira |
| CN105377749A (en) * | 2013-05-06 | 2016-03-02 | 巴伊兰大学 | Doped metal oxide nanoparticles of and uses thereof |
| CN106190112A (en) * | 2016-07-10 | 2016-12-07 | 东北师范大学 | The preparation method and applications of gold quantum dot |
| CN107041876A (en) * | 2017-03-17 | 2017-08-15 | 泰山医学院 | A kind of nano particle for killing cancer cell and preparation method thereof |
| CN107234238A (en) * | 2017-05-03 | 2017-10-10 | 太原理工大学 | A kind of core shell structure Au@Co (OH)2The preparation method of nanoparticle |
Non-Patent Citations (6)
| Title |
|---|
| HAIWEI JI ET AL: "Bacterial Hyaluronidase Self-Triggered Prodrug Release for Chemo-Photothermal Synergistic Treatment of Bacterial Infection", 《SMALL》 * |
| HANJUN SUN ET AL: "Graphene Quantum Dots-Band-Aids Used for Wound Disinfection", 《ACS NANO》 * |
| WANG Z ET AL: "Activation of biologically relevant levels of reactive oxygen species by Au/g-C3N4 hybrid nanozyme for bacteria killing and wound disinfection", 《BIOMATERIALS》 * |
| YU TAO ET AL: "Incorporating Graphene Oxide and Gold Nanoclusters: A Synergistic Catalyst with Surprisingly High Peroxidase-Like Activity Over a Broad pH Range and its Application for Cancer Cell Detection", 《ADVANCED MATERIALS》 * |
| YU TAO ET AL: "Metal nanoclusters: novel probes for diagnostic and therapeutic applications", 《ROYAL SOCIETY OF CHEMISTRY》 * |
| 刘燕等: "组氨酸功能化纳米金团簇的模拟酶活性及应用研究", 《中国化学会.中国化学会第十六届胶体与界面化学会议论文摘要集——第五分会：生命科学与医学中的胶体化学》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108420803A (en) * | 2018-04-28 | 2018-08-21 | 中国科学院长春应用化学研究所 | Nano enzyme adhesive bandage, preparation method and application method |
| CN109875762A (en) * | 2018-12-25 | 2019-06-14 | 浙江工商大学 | A kind of novel antibacterial adhesive bandage and the preparation method and application thereof |
| IT201900024132A1 (en) * | 2019-12-16 | 2021-06-16 | Idi Integratori Dietetici Italiani S R L | MIXTURE AND COMPOSITIONS BASED ON GOLD AND GRAPHENE, AND THEIR USE. |
| WO2021124023A1 (en) * | 2019-12-16 | 2021-06-24 | Idi Integratori Dietetici Italiani S.R.L. | Gold- and graphene-based mixture and compositions and use thereof |
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