CN107736872A - Method for the human eye body mould and OCT image quality evaluation of eyeground fault imaging - Google Patents
Method for the human eye body mould and OCT image quality evaluation of eyeground fault imaging Download PDFInfo
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- CN107736872A CN107736872A CN201710969455.8A CN201710969455A CN107736872A CN 107736872 A CN107736872 A CN 107736872A CN 201710969455 A CN201710969455 A CN 201710969455A CN 107736872 A CN107736872 A CN 107736872A
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/102—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for optical coherence tomography [OCT]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/14—Arrangements specially adapted for eye photography
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Abstract
The present invention relates to a kind of human eye body mould and OCT image quality evaluating method for eyeground fault imaging, human eye body mould includes anterior refractive apparatus and rear portion refractive apparatus；The anterior refractive apparatus collects light, it is imaged in the bottom surface of rear portion refractive apparatus, the cambered surface that the bottom surface of the rear portion refractive apparatus is formed for the concentric circles of different radii, structure is detected in the outer surface of cambered surface covered with retina resolution ratio, and macula lutea detection structure and optic nerve detection structure are additionally provided with the retina resolution ratio detection structure.
Description
Technical field
The present invention relates to a kind of human eye body mould for eyeground fault imaging and the method for OCT image quality evaluation.
Background technology
Optical coherence tomography (Optical Coherence Tomography, OCT) is to have developed rapidly in recent years
A kind of imaging technique come.It utilizes the general principle of weak coherent light interferometer, and measurement biological tissue different depth aspect is to entering
Penetrate the back-reflection or scattered signal, then by scanning, obtain biological tissue's two dimension or three-dimensional structure image several times of weak coherent light.
OCT has application in fields such as ophthalmology, neurology department and arterial Interventional Therapies at present, especially in field of ophthalmology, can use
Diagnosis, the diagnosis of CNV disease in macular disease, the postoperative detection of the diagnosis of retinal disease, ophthalmology disease,
The quantitative measurment of retinal nerve fibre layer, the quantitative detection of macula area central fovea and subregion, the quantitative survey of central corneal thickness
Amount etc., it can in addition contain observe the anterior chamber of eye tissue such as cornea, iris, crystalline lens, and accurate measurement related data.
OCT has the spatial resolution (micron level) of superelevation, fine fault imaging function.Due to instrument precision degree
It is higher, and be a kind of emerging imaging technique, also lack and set for OCT also without corresponding testing standard in the world at present
The new molded breadth visual field simulation human eye body mould of the special high-accuracy of standby imaging performance evaluation and image quality measure.
The content of the invention
For the deficiencies in the prior art, the invention provides a kind of human eye body mould for eyeground fault imaging,
The integrated optical feature of human eye is simulated, devises high resolution structures and the wide sight configurations for detecting image quality,
On the basis of high-caliber optical distortion and geometric distortion, it is also added into emulating macula lutea and optic nerve geometry, for checking
Evaluation is made reference with verification Ophthalmologic apparatus.
The technical scheme is that：
A kind of human eye body mould for eyeground fault imaging, applied to OCT image quality evaluation, including anterior refractive apparatus
With rear portion refractive apparatus；The anterior refractive apparatus collects light, is imaged in the bottom surface of rear portion refractive apparatus, the rear portion dioptric
The cambered surface that the bottom surface of device is formed for the concentric circles of different radii, the outer surface of cambered surface is detected covered with retina resolution ratio ties
Structure, the retina resolution ratio, which detects, is additionally provided with macula lutea detection structure and optic nerve detection structure in structure.
Further, the body mould also include one can longitudinal extension support meanss, the support meanss pass through the ball at the top of it
Body is slidably connected with being located at the hemispherical groove of the rear portion refractive apparatus bottom.
Support meanss can use three section retractable support levers, and human eye body is adjusted by the regulation of three section retractable support levers
The height of mould, multi-angle regulation can be realized by chondritic again so that need not mistake when OCT equipment is detected and verified
In cumbersome adjusting device, fine setting and detection when being easy to detect OCT to diverse location.
The hollow space of front and rear portions refractive apparatus by injecting distilled water, as artificial vitreous be used for simulate human eye into
Picture.
Further, the retina resolution ratio detection structure includes being covered in the first light being alternately arranged in the cambered surface
Quick face and the second photosurface, total number of plies of first photosurface and the second photosurface are 10 integral multiple.
Further, total number of plies of the first photosurface and the second photosurface is 20 layers, before latter 10 layers of every thickness degree is more than
10 layers of every thickness degree.
Further, the macula lutea detection structure is：Retina resolution structural is located on the left of the cambered surface axis
It is raised.
Further, the optic nerve detection structure is：The stretching unit being connected with retina resolution structural.
Further, the concentric circles includes the first sensitive annular and the second sensitive annular being alternately arranged.
Further, the anterior refractive apparatus includes cornea refractive module, aqueous humor dioptric module and the crystalline substance being sequentially connected
Shape body dioptric module.
Wherein cornea refractive module spherical crown shape transparent silicon glassy solids structure, side packing in aqueous humor dioptric module cornea refractive
Pure water, crystalline lens dioptric module is biconvex round pie transparent silicon glass structure, and anterior refractive apparatus stuck-module is
The solid structure that the hollow black ABS material 3D printing in rear portion forms.
Further, the anterior refractive apparatus or rear portion refractive apparatus use cylindrical shell, and the two passes through grafting phase
Even.And glass cement is added at gap to prevent component leak.
Wherein cylindrical shell is made up of the black PLA material of 3D printing, has higher strength and toughness, and preferably
Sealing function and opaqueness.
The invention also provides a kind of method that OCT image quality evaluation is carried out using above-mentioned human eye body mould, including：By institute
State human eye body mould to be detected as object, obtain OCT 3-D views；According to horizontal shortest dimension in the 3-D view and
Longitudinal shortest dimension, obtain the tomography depth and interlayer resolution ratio of OCT image；It can see most according in the 3-D view
Big complete concentric circles, obtains the visual field size of OCT image；Macula lutea image and optic nerve image in the 3-D view,
Obtain the macula lutea tomography, optic papilla tomography, optic nerve fiber tomography of OCT image.
Beneficial effects of the present invention：
A kind of present invention high-precision body mould special by designing means of optical coherence tomography OCT, is solved existing
Do not have also at present preferably for OCT progress quality control, image quality measure and physiological structure inspection there has been no domestic in technology
The new molded breadth visual field body mould of special high-accuracy of survey, there is detection efficiency height, simulated effect is good, precision is high, function is complete, easy to disassemble
Many-sided feature such as assemble and can easily be accommodated.
Brief description of the drawings
Fig. 1 is the overall assembling median sagittal plane profile of the present invention；
Fig. 2 is cornea refractive module (and aqueous humor dioptric module) three-view diagram of the present invention；
Fig. 3 is the crystalline lens dioptric module three-view diagram of the present invention；
Fig. 4 is the three-view diagram of the anterior dioptric system stuck-module of the present invention；
Fig. 5 is the multi-angle view of the anterior dioptric system stuck-module of the present invention；
Fig. 6 be the present invention rear portion dioptric and detection means in a. concentric circles angle of visual field geometric distortion detection modules face
Figure；
Fig. 7 is the rear portion dioptric of the present invention and the median sagittal plane profile of detection means module；
Fig. 8 is the rear portion refractive apparatus of the present invention and the multi-angle view of detection module；
Fig. 9 is the front and rear refractive apparatus of the present invention and the multi-angle view of detection means assembly；
Figure 10 is the three-view diagram of the body mould support meanss of the present invention
Wherein, 1- cornea refractives module, 2- aqueous humor dioptric modules, 3- crystalline lens dioptric modules, 4- water injection holes, 5- exhausts
Hole, 6- front portions dioptric system fixed structure, 7- imagings and detection structure (a, b module profile), 8- imagings and detection structure are (yellow
Spot detects section of structure), 9- imagings and detection structure (discus nervi optici detection module profile), 10- rear portions refractive apparatus is consolidated
Determine structure, a concentric circles angles of visual field geometric distortion detection structure, b retina high-contrasts resolution ratio detection structure.
Embodiment：
The invention will be further described with embodiment below in conjunction with the accompanying drawings：
It is noted that described further below is all exemplary, it is intended to provides further instruction to the application.It is unless another
Indicate, all technologies used herein and scientific terminology are with usual with the application person of an ordinary skill in the technical field
The identical meanings of understanding.
It should be noted that term used herein above is merely to describe embodiment, and be not intended to restricted root
According to the illustrative embodiments of the application.As used herein, unless the context clearly indicates otherwise, otherwise singulative
It is also intended to include plural form, additionally, it should be understood that, when in this manual using term "comprising" and/or " bag
Include " when, it indicates existing characteristics, step, operation, device, component and/or combinations thereof.
As background technology is introduced, there is that there has been no the comprehensive wide visuals field of OCT, more sick of being applied in the prior art
Change, high-resolution, the deficiency of the picture quality of high geometric distortion detection body mould, in order to solve technical problem as above, the application
Propose a kind of special high-precision body moulds of multifunctional wide visual field OCT.
OCT main purposes is that the central fovea and discus nervi optici of retina are imaged, and usually requires that an equipment
The angle of visual field of 10 ° of outsides of a rather moderate can be imaged.In view film edge, high-caliber optical distortion and geometric distortion
It is the major obstacle that these diseases are carried out with qualitative assessment, and it is difficult amount that these influences of distortion to retina scanning, which are,
Change and compare.Therefore the present invention adds the geometry of emulation macula lutea and discus nervi optici in design, to detect OCT to depositing
It is the imaging and detection of the lesion at above-mentioned two position.
It is proposed by the present invention to simulate human eye body mould, distilled water is full of to imitate the liquid environment in eyeball between each portion.Make
Image contrast and the characteristic size related to OCT with the clearly defined geometry that can produce wide scope, use two
The material manufacture body moulds such as silica, silica glass, photosensitive imaging 3D printing resin.
In a kind of typical embodiment of the application, as shown in Fig. 1-Figure 10, there is provided high accuracy special a kind of OCT
Human eye body mould, including：
A. anterior refractive apparatus：Cornea refractive module, aqueous humor dioptric module, crystalline lens dioptric module, anterior refractive apparatus
Stuck-module.Wherein cornea refractive module spherical crown shape transparent silicon dioxide glass structure, aqueous humor dioptric module cornea refractive inner side
The pure water of encapsulation, crystalline lens dioptric module are biconvex round pie transparent silicon glass structure, anterior refractive apparatus stent
Block is the solid structure that the hollow black ABS material 3D printing in rear portion forms.
B. rear portion refractive apparatus：Including the artificial vitreous region combined with anterior refractive apparatus, rear portion dioptric dress
Structure is detected in the cambered surface that the bottom surface put is formed for the concentric circles of different radii, the outer surface of cambered surface covered with retina resolution ratio,
Macula lutea detection structure and optic nerve detection structure are additionally provided with retina resolution ratio detection structure.
Retina resolution ratio detection structure includes being covered in the first photosurface and the second light being alternately arranged in the cambered surface
Total number of plies of quick face, the first photosurface and the second photosurface is 10 integral multiple, you can be 10 layers, 20 layers, 30 layers etc..
Macula lutea detection structure is the projection that retina resolution structural is located on the left of the cambered surface axis.
Optic nerve detection structure is the stretching unit being connected with retina resolution structural.
C. body mould support meanss：For the three scalable metallic support rods of section, height can be adjusted according to actual conditions, and play branch
Support fixation.
A, B two parts are connected with inserting mode, and add glass cement at gap to prevent component leak.B, C two parts
Connected by the dome-type groove in part B with the spheroid at the top of C portion, not only played a part of supporter mould but also can be according to not
With OCT detection demand, proper angle is adjusted.
A, the stuck-module in part B is made up of the black PLA material of 3D printing, has higher strength and toughness, with
And preferable sealing function and opaqueness.
A, in B, C portion in addition to C portion is metal material, remaining is a variety of nonmetallic materials.
Described each part dimension by calculating, meets optical principle, while compares normal eyeball, has high emulation
And pinpoint accuracy.
As shown in Fig. 2 described cornea refractive module radius 7.72mm, thickness 0.55mm.Described aqueous humor dioptric module
Radius 6.5mm, thickness 3.05mm, making material are distilled water, are encapsulated in after cornea refractive module.The two is jointly to incident light
Line plays refraction action.
As shown in figure 3, described crystalline lens dioptric module front portion subsequent corrosion 10.2mm, rear curved surface radius 11.22mm,
Thickness 3.93mm, making material are the high glass of transparency, and main refraction action is played to incident ray.For refractive apparatus
Primary clustering.
As shown in Figure 4, Figure 5, described anterior dioptric system stuck-module, it is the stuck-module of above three module.It is whole
Shape is cylinder, and left and right footpath 30mm, anteroposterior diameter 9mm are black to be made using black PLA material by 3D printer
Color hollow solid shell structure.
Water injection hole 4, steam vent 5 arranged at top, front portion for hollow two cylindrical holes (be used to disposing cornea refractive module and
The bore dia of aqueous humor dioptric module is 12mm, depth 0.55mm, for disposing the bore dia 9mm of crystalline lens dioptric module, depth
3.93mm) it is used to place dioptric module, rear portion is hollow structure, and with 6 root long 5mm diameters 2mm grafting rod, for A, B
Partial combination connection.
Vitreum refractive apparatus is that A, B combine the distilled water that rear right water injection hole adds, normal to simulate to greatest extent
The vitreum of eyeball dioptric effect, by artificial vitreous's rear curved surface, the horizontal range to view film module is
16.32mm。
As shown in fig. 6, in described rear portion refractive apparatus：
A. high scattering that the front view of concentric circles angle of visual field geometric distortion detection module has been 16 chequered with black and white fusions and
The concentric circular bars of high-selenium corn material combine, and the device is used for providing distortion and the feature of the angle of visual field of body mould, this design
The photosensitive shaping 3D printing material of black and white of high scattering and high-selenium corn material has been merged, has utilized the more shower nozzle 3D printings of high accuracy
Disposably printing is made machine.
The alternating widths of both materials are respectively 1mm and 0.1mm, pass through the imaging to two-dimensional grid, it is possible to reduce into
As the distortion in system.White material is often used as the scatterplot of microstructure modeling, and black material increases the absorption to light.
It is the macula lutea detection module of design, a diameter of 1mm, to emulate the true eyeground structure of human eye on the left of axis.
As shown in fig. 7, in described rear portion refractive apparatus：
B is that retina high-contrast resolution ratio detection structure is that 20 layers of photosensitive shaping 3D printing material printing alternate form
Structure, first 10 layers every 60 μm of thickness degree, two kinds of materials are alternately sequentially overlapped, latter 10 layers every 120 μm of thickness degree.
Structure is mainly used as being imaged target, emulates ten Rotating fields of human eye retina, tests the precision of imaging, including level
The visual field degree of accuracy, refers in particular to fundus image.And the tomography depth and interlayer resolution ratio of test fault imaging, B-scan pattern is refered in particular to, is broken
Layer macula lutea, optic disk/optic papilla and layer of optic fibers imaging.
Fig. 7-8 is imaged and detection module (macula lutea detection module profile) enlarged drawing, to simulate the detection module of macula lutea,
Fig. 7-9 is imaged and detection module (discus nervi optici detection module profile) enlarged drawing, for simulation discus nervi optici and regards
The detection module of neuromechanism.Fig. 7-8 and Fig. 7-9 liangs of module is the structure of physiological emulation.
As shown in figure 8, rear portion refractive apparatus and detection module, outward appearance is anteroposterior diameter 19mm, left and right footpath 30mm cylinder；It is interior
There is Radius 12mm hollow hemisphere in portion.A is concentric circles angle of visual field geometric distortion detection module bottom to the bottom of the module
Thickness is 7mm.There are 6 diameter 2mm on periphery, depth 5mm cylindrical hole, is combined with anterior refractive apparatus supporting module by this
Structure connects.One diameter 6.2mm hemisphere is arranged at bottom, is the association part of C. body mould support meanss.
As shown in figure 9, the outward appearance after front and rear refractive apparatus grafting is got up is anteroposterior diameter 40mm, left and right footpath 30mm, it is anterior
For the cylindrical-shaped structure of transparent lens.Gap is sealed assembly with waterproof glass glue everywhere, to prevent aqueous humor dioptric module
Leaked outside with the distilled water of vitreum dioptric module.
As shown in Figure 10, human eye body mould support meanss, by the scalable metallic rod of three section stainless steels and stainless steel metal base
Combine, the regulation of height can be carried out according to actual conditions.Top is diameter 6mm ball, and the ball passes through half in B portions
Circular hole, A, B assembly and C are combined, while spherical structure can rotate upwardly and downwardly A, part B, when being easy to detect OCT
The regulation of multi-angle.
A kind of present invention high-precision body mould special by designing means of optical coherence tomography OCT, is solved existing
Do not have also at present preferably for OCT progress quality control, image quality measure and physiological structure inspection there has been no domestic in technology
The new molded breadth visual field body mould of special high-accuracy of survey, there is detection efficiency height, simulated effect is good, precision is high, function is complete, easy to disassemble
The characteristics of assembling and can easily be accommodated.
Casing part and optical imagery refractive apparatus can use 3D printing technique, choose certain material printing；Each portion it
Between full of distilled water to imitate the liquid environment in eyeball.Use the light for the clearly defined geometry that can produce wide scope
Contrast and the characteristic size related to OCT are carved, uses the material systems such as silica, silica glass, photosensitive imaging 3D printing resin
Make body mould.Patent describes the design of the body mould and making, this body mould will play an important role in OCT standard formulation,
And the assessment of quantitative performance can be carried out.
Using above-mentioned human eye body mould, applied to OCT image, another embodiment of the present invention, a kind of OCT image are just given
Quality evaluating method：The human eye body mould is detected as object, obtains OCT 3-D views；According to the graphics
Horizontal shortest dimension and longitudinal shortest dimension as in, obtain the tomography depth and interlayer resolution ratio of OCT image；According to the three-dimensional
The maximum complete concentric circles that can be seen in image, obtains the visual field size of OCT image；According to the macula lutea in the 3-D view
Image and optic nerve image, the macula lutea tomography, optic papilla tomography, optic nerve fiber tomography of OCT image are obtained, using described
Macula lutea tomography, optic papilla tomography and optic nerve fiber tomography evaluation OCT image quality.
By using human eye body mould proposed by the present invention, one can be obtained from OCT image closer to wide-field
Imaging, and due to view film edge, it is difficult to quantify that the influence of high-caliber optical distortion and geometric distortion to retina scanning, which is,
With compare, based on the emulation macula lutea of the present invention and the geometry of discus nervi optici, OCT can be detected to being present in above-mentioned two
The imaging of the lesion of position.
The preferred embodiment of the application is the foregoing is only, is not limited to the application, for the skill of this area
For art personnel, the application can have various modifications and variations.It is all within spirit herein and principle, made any repair
Change, equivalent substitution, improvement etc., should be included within the protection domain of the application.
Claims (10)
- A kind of 1. human eye body mould for eyeground fault imaging, applied to OCT image quality evaluation, it is characterised in that including preceding Portion's refractive apparatus and rear portion refractive apparatus；The anterior refractive apparatus collects light, is imaged in the bottom surface of rear portion refractive apparatus, institute The cambered surface that the bottom surface of rear portion refractive apparatus is formed for the concentric circles of different radii is stated, the outer surface of cambered surface is differentiated covered with retina Rate detects structure, and macula lutea detection structure and optic nerve detection structure are additionally provided with the retina resolution ratio detection structure.
- 2. human eye body mould according to claim 1, it is characterised in that also including one can longitudinal extension support meanss, should Support meanss are slidably connected by the spheroid at the top of it with being located at the hemispherical groove of the rear portion refractive apparatus bottom.
- 3. human eye body mould according to claim 1, it is characterised in that the retina resolution ratio detection structure includes covering The first photosurface and the second photosurface being alternately arranged in the cambered surface, total layer of first photosurface and the second photosurface Number is 10 integral multiple.
- 4. human eye body mould according to claim 1, it is characterised in that the macula lutea detects structure and is：Retina resolution ratio Structure is located at the projection on the left of the cambered surface axis.
- 5. human eye body mould according to claim 1, it is characterised in that the optic nerve detects structure and is：With retina point The stretching unit of resolution structure connection.
- 6. human eye body mould according to claim 1, it is characterised in that the concentric circles includes being alternately arranged first photosensitive Annulus and the second sensitive annular.
- 7. human eye body mould according to claim 3, it is characterised in that total number of plies of the first photosurface and the second photosurface is 20 layers, latter 10 layers of every thickness degree is more than first 10 layers of every thickness degree.
- 8. human eye body mould according to claim 1, it is characterised in that the anterior refractive apparatus includes the angle being sequentially connected Film dioptric module, aqueous humor dioptric module and crystalline lens dioptric module.
- 9. human eye body mould according to claim 1, it is characterised in that the anterior refractive apparatus or rear portion refractive apparatus are adopted With cylindrical shell, the two is connected by grafting.
- A kind of 10. OCT image quality evaluating method based on any one of claim 1-9, it is characterised in that including：By institute State human eye body mould to be detected as object, obtain OCT 3-D views；According to horizontal shortest dimension in the 3-D view and Longitudinal shortest dimension, obtain the tomography depth and interlayer resolution ratio of OCT image；It can see most according in the 3-D view Big complete concentric circles, obtains the visual field size of OCT image；Macula lutea image and optic nerve image in the 3-D view, The macula lutea tomography, optic papilla tomography, optic nerve fiber tomography of OCT image are obtained, utilizes the macula lutea tomography, optic nerve breast Head tomography and optic nerve fiber tomography evaluation OCT image quality.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710969455.8A CN107736872A (en) | 2017-10-18 | 2017-10-18 | Method for the human eye body mould and OCT image quality evaluation of eyeground fault imaging |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710969455.8A CN107736872A (en) | 2017-10-18 | 2017-10-18 | Method for the human eye body mould and OCT image quality evaluation of eyeground fault imaging |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108371541A (en) * | 2018-03-20 | 2018-08-07 | 视微影像(河南)科技有限公司 | A kind of tool for detecting and calibrating ophthalmology imaging, ophthalmology biological parameter measuring instrument |
| WO2020153575A1 (en) | 2019-01-23 | 2020-07-30 | 한국표준과학연구원 | Eye phantom for evaluating retinal angiography image |
| CN112220448A (en) * | 2020-10-14 | 2021-01-15 | 上海鹰瞳医疗科技有限公司 | Fundus camera and fundus image synthesis method |
| US12011223B2 (en) | 2019-01-23 | 2024-06-18 | Korea Research Institute Of Standards And Science | Eye phantom for evaluating retinal angiography image |
-
2017
- 2017-10-18 CN CN201710969455.8A patent/CN107736872A/en not_active Withdrawn
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108371541A (en) * | 2018-03-20 | 2018-08-07 | 视微影像(河南)科技有限公司 | A kind of tool for detecting and calibrating ophthalmology imaging, ophthalmology biological parameter measuring instrument |
| CN108371541B (en) * | 2018-03-20 | 2024-01-16 | 视微影像(河南)科技有限公司 | Tool for detecting and calibrating ophthalmic imaging and ophthalmic biological parameter measuring instrument |
| WO2020153575A1 (en) | 2019-01-23 | 2020-07-30 | 한국표준과학연구원 | Eye phantom for evaluating retinal angiography image |
| US12011223B2 (en) | 2019-01-23 | 2024-06-18 | Korea Research Institute Of Standards And Science | Eye phantom for evaluating retinal angiography image |
| CN112220448A (en) * | 2020-10-14 | 2021-01-15 | 上海鹰瞳医疗科技有限公司 | Fundus camera and fundus image synthesis method |
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Application publication date: 20180227 |